Page last updated: 2024-10-23

azathioprine and Celiac Sprue

azathioprine has been researched along with Celiac Sprue in 23 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"Treatment of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) with ursodeoxycholic acid (UDCA) has been in common use since 1985."4.81Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. ( Holtmeier, J; Leuschner, U, 2001)
" In order to minimize their systemic side effects, we assessed the role of a locally active sustained release corticosteroid with minimal systemic bioavailability in patients with refractory celiac disease in an open labeled noncontrolled study."2.73Budesonide in the treatment of refractory celiac disease. ( Bhagat, G; Brar, P; Egbuna, I; Green, PH; Lee, S; Lewis, S, 2007)
"Refractory sprue is a rare and severe malabsorptive disorder that mimics celiac disease but is refractory to a gluten-free diet and is without initial evidence of overt lymphoma."2.70Azathioprine in refractory sprue: results from a prospective, open-label study. ( Bai, JC; Cabanne, A; Capucchio, M; Cherñavsky, A; Fiorini, A; Kogan, Z; Mauriño, E; Mazure, R; Niveloni, S; Pedreira, S; Reyes, H; Smecuol, E; Vazquez, H, 2002)
"Autoimmune cholangitis is a rare chronic cholestatic liver disease."2.40Autoimmune cholangitis in a patient with celiac disease: a case report and review of the literature. ( Gogos, CA; Nikolopoulou, V; Siampi, V; Vagenakis, A; Zolota, V, 1999)
"The disease is rarely associated with Crohn's disease (CRD)."1.43Coexistence of Celiac and Crohn's Disease in a Patient Presenting with Chronic Diarrhea. ( Abbas, Z; Butt, MO; Laeq, SM; Lail, G; Luck, NH; Mubarak, M; Tasneem, AA, 2016)
"On liver biopsy, a diagnosis of type I autoimmune hepatitis with a possible autoimmune cholangitis overlap syndrome was made."1.32Autoimmune hepatitis, cryoglobulinaemia and untreated coeliac disease: a case report. ( Biecker, E; Reichen, J; Stieger, M; Zimmermann, A, 2003)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19905 (21.74)18.7374
1990's4 (17.39)18.2507
2000's8 (34.78)29.6817
2010's6 (26.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kini, GP1
McAlindon, ME1
Schultz, M1
Collett, J1
Murray, IA1
Vo, HD1
Xu, J1
Rabinowitz, SS1
Fisher, SE1
Schwarz, SM1
Chebli, JM1
Reboredo, MM1
Pinheiro, HS1
Pinheiro, Bdo V1
Lail, G1
Tasneem, AA1
Butt, MO1
Luck, NH1
Laeq, SM1
Abbas, Z1
Mubarak, M1
Rowinski, SA1
Christensen, E1
Kaukinen, K1
Ilus, T1
Vornanen, M1
Collin, P1
Mauriño, E1
Niveloni, S1
Cherñavsky, A1
Pedreira, S1
Mazure, R1
Vazquez, H1
Reyes, H1
Fiorini, A1
Smecuol, E1
Cabanne, A1
Capucchio, M1
Kogan, Z1
Bai, JC1
Biecker, E1
Stieger, M1
Zimmermann, A1
Reichen, J1
Goerres, MS1
Meijer, JW1
Wahab, PJ1
Kerckhaert, JA1
Groenen, PJ1
Van Krieken, JH1
Mulder, CJ1
Medlicott, SA1
Coderre, S1
Horne, G1
Panaccione, R1
Brar, P1
Lee, S1
Lewis, S1
Egbuna, I1
Bhagat, G1
Green, PH1
Rovelli, A1
Corti, P1
Beretta, C1
Bovo, G1
Conter, V1
Mieli-Vergani, G1
Cordonnier, M1
Robin, M1
Cornette, M1
Brassinne, A1
Pirotte, J1
O'Mahony, S1
Howdle, PD1
Losowsky, MS1
Rolny, P1
Sigurjonsdottir, HA1
Remotti, H1
Nilsson, LA1
Ascher, H1
Tlaskalova-Hogenova, H1
Tuckova, L1
Gogos, CA1
Nikolopoulou, V1
Zolota, V1
Siampi, V1
Vagenakis, A1
Vaidya, A1
Bolanos, J1
Berkelhammer, C1
Holtmeier, J1
Leuschner, U1
Stiefelhagen, P1
Hamilton, JD1
Chambers, RA1
Wynn-Williams, A1
Adams, D1
Clements, D1
Elias, E1
Jensen, KB1
Lane, DJ1
Hamilton, WS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Diagnostic Role of Enteroscopy in Small Intestinal Diseases at Al-Rajhi University Hospital[NCT05470946]50 participants (Anticipated)Interventional2022-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for azathioprine and Celiac Sprue

ArticleYear
The liver in pediatric gastrointestinal disease.
    Journal of pediatric gastroenterology and nutrition, 2014, Volume: 59, Issue:3

    Topics: Adolescent; Antibodies, Monoclonal; Azathioprine; Celiac Disease; Chemical and Drug Induced Liver In

2014
Epidemiologic and therapeutic aspects of refractory coeliac disease - a systematic review.
    Danish medical journal, 2016, Volume: 63, Issue:12

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Celiac Disease; Cla

2016
[When gluten-free diet does not cure celiac disease].
    Duodecim; laaketieteellinen aikakauskirja, 2012, Volume: 128, Issue:9

    Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Azathioprine; Biomarkers; Celiac Disease;

2012
Review article: management of patients with non-responsive coeliac disease.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:5

    Topics: Azathioprine; Celiac Disease; Clinical Trials as Topic; Copper; Cyclosporine; Diet; Food, Fortified;

1996
Autoimmune cholangitis in a patient with celiac disease: a case report and review of the literature.
    Journal of hepatology, 1999, Volume: 30, Issue:2

    Topics: Aged; Autoimmune Diseases; Azathioprine; Celiac Disease; Cholangitis; Drug Therapy, Combination; Fem

1999
Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis.
    Digestion, 2001, Volume: 64, Issue:3

    Topics: Azathioprine; Celiac Disease; Cholagogues and Choleretics; Cholangitis, Sclerosing; Drug Therapy, Co

2001
The treatment of primary biliary cirrhosis.
    Journal of clinical and hospital pharmacy, 1986, Volume: 11, Issue:2

    Topics: Adrenal Cortex Hormones; Antipruritics; Azathioprine; Celiac Disease; Chlorambucil; Colchicine; Cycl

1986
IgM turnover in man.
    Ciba Foundation symposium, 1972, Volume: 9

    Topics: Abscess; Adult; Azathioprine; Celiac Disease; Chronic Disease; Clone Cells; Crohn Disease; Feces; Ga

1972

Trials

3 trials available for azathioprine and Celiac Sprue

ArticleYear
Azathioprine in refractory sprue: results from a prospective, open-label study.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:10

    Topics: Adult; Aged; alpha 1-Antitrypsin; Autoantibodies; Azathioprine; Biopsy, Needle; Body Weight; Celiac

2002
Azathioprine and prednisone combination therapy in refractory coeliac disease.
    Alimentary pharmacology & therapeutics, 2003, Sep-01, Volume: 18, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Azathioprine; Celiac Disease; Drug Therapy

2003
Budesonide in the treatment of refractory celiac disease.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:10

    Topics: Adult; Aged; Azathioprine; Budesonide; Celiac Disease; Combined Modality Therapy; Female; Follow-Up

2007

Other Studies

12 other studies available for azathioprine and Celiac Sprue

ArticleYear
Education and Imaging. Gastrointestinal: Capsule endoscopy of a very refractory celiac disease.
    Journal of gastroenterology and hepatology, 2013, Volume: 28, Issue:8

    Topics: Azathioprine; Capsule Endoscopy; Celiac Disease; Diet, Gluten-Free; Female; Humans; Hydrocortisone;

2013
Hypertransaminasemia following withdrawal of thiopurine therapy in an ulcerative colitis patient: mind looking the small bowel!
    International journal of colorectal disease, 2015, Volume: 30, Issue:12

    Topics: Azathioprine; Celiac Disease; Colitis, Ulcerative; Duodenum; Female; Humans; Immunosuppressive Agent

2015
Coexistence of Celiac and Crohn's Disease in a Patient Presenting with Chronic Diarrhea.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016, Volume: 26, Issue:6

    Topics: Antirheumatic Agents; Azathioprine; Celiac Disease; Colonoscopy; Crohn Disease; Diarrhea; Diet, Glut

2016
Autoimmune hepatitis, cryoglobulinaemia and untreated coeliac disease: a case report.
    European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:4

    Topics: Anti-Inflammatory Agents; Azathioprine; Celiac Disease; Cryoglobulinemia; Female; Hepatitis, Autoimm

2003
Multimodal immunosuppressant therapy in steroid-refractory common variable immunodeficiency sprue: a case report complicating cytomegalovirus infection.
    International journal of surgical pathology, 2006, Volume: 14, Issue:1

    Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Antiviral Agents; Azathioprine; Celiac Disease; Com

2006
Alemtuzumab for giant cell hepatitis with autoimmune hemolytic anemia.
    Journal of pediatric gastroenterology and nutrition, 2007, Volume: 45, Issue:5

    Topics: Alemtuzumab; Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanize

2007
[Neurologic complications of celiac disease in adults. Apropos of a case].
    Revue medicale de Liege, 1983, Nov-01, Volume: 38, Issue:21

    Topics: Aged; Azathioprine; Celiac Disease; Combined Modality Therapy; Female; Humans; Methylprednisolone; N

1983
Role of immunosuppressive therapy in refractory sprue-like disease.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:1

    Topics: Azathioprine; Celiac Disease; Cyclosporine; Duodenum; Humans; Immunosuppressive Agents; Jejunum; Mal

1999
Azathioprine in refractory sprue.
    The American journal of gastroenterology, 1999, Volume: 94, Issue:7

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Celiac Disease; Humans; Immunosuppressive Agents; Mal

1999
[In order to prevent anemia, osteoporosis and malignant lymphoma, sprue even with few symptoms has to be treated].
    MMW Fortschritte der Medizin, 2002, Feb-28, Volume: 144, Issue:9

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Biopsy; Celiac Disease; Child; Gliadin; Hu

2002
Role of gluten, prednisone, and azathioprine in non-responsive coeliac disease.
    Lancet (London, England), 1976, Jun-05, Volume: 1, Issue:7971

    Topics: Administration, Oral; Azathioprine; Celiac Disease; Drug Therapy, Combination; Female; Glutens; Huma

1976
Idiopathic steatorrhoea and idiopathic pulmonary haemosiderosis.
    British medical journal, 1971, Apr-10, Volume: 2, Issue:5753

    Topics: Adult; Azathioprine; Celiac Disease; Folic Acid Deficiency; Hemoglobinometry; Hemoptysis; Hemosidero

1971