azathioprine has been researched along with Cardiac Failure in 32 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Out of 652 biopsied patients, 112 had a histological diagnosis of active lymphocytic myocarditis; 41 of these 112 patients were characterized by progressive heart failure despite conventional therapy and were treated with prednisone and azathioprine for 6 months." | 3.72 | Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. ( Calabrese, F; Chimenti, C; Frustaci, A; Maseri, A; Pieroni, M; Thiene, G, 2003) |
| " Immunosuppressive therapy with prednisolone 2 mg/kg/d and azathioprine 2 mg/kg/d was added on the assumption of chronic myocarditis (n = 4) or endocardial fibrosis (n = 2)." | 3.67 | [Immunosuppressive treatment of chronic myocarditis]. ( Proll, E; Salzer-Muhar, U; Schlemmer, M; Strigl, E; Wimmer, M, 1988) |
| "Our results do not support routine treatment of myocarditis with immunosuppressive drugs." | 2.68 | A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. ( Billingham, ME; Herskowitz, A; Mason, JW; McManus, BM; Moon, TE; O'Connell, JB; Rose, NR, 1995) |
| "Heart failure is a rare but life-threatening manifestation of cardiac involvement in SLE." | 1.35 | Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus. ( Bax, JJ; Boumpas, DT; Huizinga, TW; Kritikos, H; Mollema, SA; Schoe, A; van der Laan-Baalbergen, NE; van Laar, JM, 2009) |
| "Biopsies then taken revealed recurrence of myocarditis in the transplanted heart." | 1.28 | Response of recurrent giant cell myocarditis in a transplanted heart to intensive immunosuppression. ( Kong, G; Madden, B; Mitchell, A; Pomerance, A; Spyrou, N; Yacoub, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 3 (9.38) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, MY | 1 |
| Li, D | 1 |
| Feldman, CH | 1 |
| Yoshida, K | 1 |
| Guan, H | 1 |
| Kim, SC | 1 |
| Everett, BM | 1 |
| Costenbader, KH | 1 |
| Fujiwara, K | 1 |
| Hamuro, M | 1 |
| Imai, K | 1 |
| Yoshizawa, K | 1 |
| Ohno, N | 1 |
| Sakazaki, H | 1 |
| Tsukuda, K | 1 |
| Lin, YC | 1 |
| Oliveira, GH | 1 |
| Villa-Forte, A | 1 |
| Kittleson, MM | 1 |
| Kobashigawa, JA | 1 |
| Pineton de Chambrun, M | 1 |
| Charron, P | 1 |
| Vauthier-Brouzes, D | 1 |
| Cluzel, P | 1 |
| Haroche, J | 1 |
| Kahn, JE | 1 |
| Amoura, Z | 1 |
| Aubart, FC | 1 |
| Weitsman, T | 1 |
| Weisz, G | 1 |
| Keren, A | 1 |
| Hasin, T | 1 |
| Latushko, A | 1 |
| Ghazi, LJ | 1 |
| Frustaci, A | 3 |
| Russo, MA | 1 |
| Chimenti, C | 3 |
| van der Laan-Baalbergen, NE | 1 |
| Mollema, SA | 1 |
| Kritikos, H | 1 |
| Schoe, A | 1 |
| Huizinga, TW | 1 |
| Bax, JJ | 1 |
| Boumpas, DT | 1 |
| van Laar, JM | 1 |
| Tarner, IH | 1 |
| Lange, U | 1 |
| Madlener, K | 1 |
| Classen, K | 1 |
| Kandolf, R | 2 |
| Sperzel, J | 1 |
| Müller-Ladner, U | 1 |
| Naniwa, T | 1 |
| Takeda, Y | 1 |
| Möller, K | 1 |
| Klingel, K | 1 |
| Kaiser, U | 1 |
| Thum, M | 1 |
| Bönig, A | 1 |
| Hasenfuss, G | 1 |
| Scholz, KH | 1 |
| Calabrese, F | 1 |
| Pieroni, M | 1 |
| Thiene, G | 1 |
| Maseri, A | 2 |
| Beitzke, A | 1 |
| Suppan, C | 1 |
| Trittenwein, G | 1 |
| Uberfuhr, P | 1 |
| Reichart, B | 1 |
| Welz, A | 1 |
| Kreuzer, E | 1 |
| Kemkes, BM | 1 |
| Klinner, W | 1 |
| Hammer, C | 1 |
| Ertel, W | 1 |
| Reichenspurner, H | 1 |
| Gokel, M | 1 |
| Land, W | 1 |
| Franke, N | 1 |
| Mathes, P | 1 |
| Mason, JW | 1 |
| O'Connell, JB | 1 |
| Herskowitz, A | 2 |
| Rose, NR | 1 |
| McManus, BM | 1 |
| Billingham, ME | 1 |
| Moon, TE | 1 |
| Gehrke, D | 1 |
| Herzum, M | 1 |
| Schönian, U | 1 |
| Klein, HH | 1 |
| Drude, L | 1 |
| Mennel, HD | 1 |
| Maisch, B | 1 |
| Veness, MJ | 1 |
| Khalaf, TH | 1 |
| Strober, S | 1 |
| Garrelts, G | 1 |
| Stinson, EB | 2 |
| Desjardins, V | 1 |
| Pelletier, G | 1 |
| Leung, TK | 1 |
| Waters, D | 1 |
| Jones, SR | 1 |
| Hutchins, GM | 1 |
| Baughman, KL | 1 |
| Kong, G | 1 |
| Madden, B | 1 |
| Spyrou, N | 1 |
| Pomerance, A | 1 |
| Mitchell, A | 1 |
| Yacoub, M | 1 |
| Bilińska, ZT | 1 |
| Ruzyłło, W | 1 |
| Lubiszewska, B | 1 |
| Gajewski, W | 1 |
| Wimmer, M | 1 |
| Proll, E | 1 |
| Salzer-Muhar, U | 1 |
| Schlemmer, M | 1 |
| Strigl, E | 1 |
| Nora, JJ | 1 |
| Cooley, DA | 1 |
| Fernbach, DJ | 1 |
| Rochelle, DG | 1 |
| Milam, JD | 1 |
| Montgomery, JR | 1 |
| Leachman, RD | 1 |
| Butler, WT | 1 |
| Rossen, RD | 1 |
| Bloodwell, RD | 1 |
| Hallman, GL | 1 |
| Trentin, JJ | 1 |
| Schroeder, JS | 1 |
| Popp, RL | 1 |
| Dong, E | 1 |
| Shumway, NE | 1 |
| Harrison, DC | 1 |
| Cagli, V | 1 |
| Eales, L | 1 |
| Grosser, Y | 1 |
| Levey, M | 1 |
| Dubost, C | 1 |
| Cachera, JP | 1 |
| Böttcher, D | 1 |
| Maas, D | 1 |
| Wendt, F | 1 |
| Schubothe, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| RANDOMIZED, MULTICENTRIC STUDY COMPARING THE EFFECT OF TWO REGIMENS OF COMBINED IMMUNOSUPPRESSIVE THERAPY IN THE TREATMENT OF INFLAMMATORY CARDIOMYOPATHY CZECH-ICIT (CZECH INFLAMMATORY CARDIOMYOPATHY IMMUNOSUPPRESSION TRIAL)[NCT01877746] | Phase 3 | 234 participants (Anticipated) | Interventional | 2013-01-31 | Recruiting | ||
| Cardiac Magnetic Resonance Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance[NCT03525639] | 80 participants (Anticipated) | Interventional | 2016-12-06 | Recruiting | |||
| Single-blind, Investigator-initiated, Randomized, Controlled Trial to Assess the Safety and Efficacy of Intravenous Corticosteroid Therapy to Treat Patients With Acute Myocarditis With Mildly Reduced Left Ventricular Ejection Fraction[NCT05974462] | Phase 3 | 174 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| [NCT00000524] | Phase 2 | 0 participants | Interventional | 1986-07-31 | Completed | ||
| Single Blind Randomized Controlled Trial to Assess the Safety and Efficacy of High Dose Pulse Intravenous Corticosteroid Therapy to Treat Patients With Complicated/Fulminant Acute Myocarditis[NCT05150704] | Phase 3 | 288 participants (Anticipated) | Interventional | 2021-10-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for azathioprine and Cardiac Failure
| Article | Year |
|---|---|
Management of the ACC/AHA Stage D patient: cardiac transplantation.
Topics: Allografts; Azathioprine; Cardiotonic Agents; Contraindications; Graft Occlusion, Vascular; Graft Re | 2014 |
[Course and prognosis of glomerulonephritis].
Topics: Acute Disease; Age Factors; Anti-Bacterial Agents; Anti-Glomerular Basement Membrane Disease; Antige | 1970 |
2 trials available for azathioprine and Cardiac Failure
| Article | Year |
|---|---|
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study.
Topics: Adolescent; Adult; Aged; Azathioprine; Chronic Disease; Double-Blind Method; Heart Failure; Humans; | 2009 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators.
Topics: Adult; Autoantibodies; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Heart Failure; | 1995 |
28 other studies available for azathioprine and Cardiac Failure
| Article | Year |
|---|---|
Comparative risks of cardiovascular disease events among SLE patients receiving immunosuppressive medications.
Topics: Adult; Azathioprine; Cardiovascular Diseases; Cause of Death; Coronary Artery Bypass; Cyclophosphami | 2021 |
Severe aortic valve regurgitation due to Takayasu's aortoarteritis in a child.
Topics: Aneurysm, False; Aorta, Thoracic; Aortic Valve Insufficiency; Azathioprine; Cardiac Catheterization; | 2013 |
Churg-Strauss syndrome and persistent heart failure: active disease or damage?
Topics: Azathioprine; Churg-Strauss Syndrome; Cyclophosphamide; Drug Therapy, Combination; Female; Heart Fai | 2013 |
Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report.
Topics: Adult; Azathioprine; Endomyocardial Fibrosis; Female; Heart Failure; Humans; Hypereosinophilic Syndr | 2015 |
Prompt benefit of early immunosuppressive therapy in acute lymphocytic myocarditis with persistent heart failure.
Topics: Adult; Azathioprine; Biopsy; Drug Therapy, Combination; Female; Heart Failure; Humans; Immunosuppres | 2016 |
A Case of Thiopurine-Induced Acute Myocarditis in a Patient with Ulcerative Colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Azathioprine; Cardiac Imaging Techniqu | 2016 |
Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus.
Topics: Adult; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Heart Failure; Humans; Immunosuppres | 2009 |
[A wolf in sheep's clothing: atypical systemic lupus erythematosus (SLE) presenting as cardiovascular disease].
Topics: Antiphospholipid Syndrome; Azathioprine; Biopsy; Diagnosis, Differential; Female; Heart Failure; Hea | 2010 |
Long-term remission of pulmonary veno-occlusive disease associated with primary Sjögren's syndrome following immunosuppressive therapy.
Topics: Azathioprine; Female; Heart Failure; Humans; Hypertension, Pulmonary; Immunosuppressive Agents; Pred | 2011 |
[Immunsuppressive therapy in virus-negative eosinophilic inflammatory cardiomyopathy].
Topics: Azathioprine; Biopsy; Cardiac Output, Low; Defibrillators, Implantable; Electrocardiography; Eosinop | 2011 |
Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders.
Topics: Adolescent; Adult; Autoantibodies; Azathioprine; Biopsy; Cardiotonic Agents; Chronic Disease; Echoca | 2003 |
[Immunosuppressive therapy in congestive cardiomyopathy in childhood].
Topics: Adolescent; Autoantibodies; Autoimmune Diseases; Azathioprine; Cardiomyopathy, Dilated; Child; Elect | 1984 |
[Report on a successful orthotopic cardiac transplantation in Germany].
Topics: Adrenal Cortex Hormones; Adult; Antilymphocyte Serum; Azathioprine; Creatinine; Cyclosporins; Dipyri | 1982 |
[Eosinophilic endomyocarditis post partum or pregnancy-related cardiomyopathy].
Topics: Adult; Azathioprine; Biopsy; Combined Modality Therapy; Cytomegalovirus Infections; Diagnosis, Diffe | 1994 |
Cardiac transplant-related cutaneous malignancies in an Australian recipient: immunosuppression, friend or foe?
Topics: Adult; Australia; Azathioprine; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cy | 1998 |
Global biventricular dysfunction in patients with asymptomatic coronary artery disease may be caused by myocarditis.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Autoimmune Diseases; Azathioprine; Biopsy; Cardiomy | 1999 |
Alterations in T and B lymphocytes in heart transplant patients early and late postoperatively.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; B-Lymphocytes; Female; Graft Rejection; Heart | 1976 |
Successful treatment of severe heart failure caused by idiopathic giant cell myocarditis.
Topics: Autoimmune Diseases; Azathioprine; Biopsy; Cardiomyopathy, Dilated; Cyclosporine; Drug Therapy, Comb | 1992 |
Effects of immunosuppressive therapy in biopsy-proved myocarditis and borderline myocarditis on left ventricular function.
Topics: Adolescent; Adult; Aged; Azathioprine; Echocardiography; Female; Heart Failure; Hemodynamics; Humans | 1991 |
Response of recurrent giant cell myocarditis in a transplanted heart to intensive immunosuppression.
Topics: Adult; Azathioprine; Biopsy; Cyclosporins; Granuloma, Giant Cell; Heart Failure; Heart Transplantati | 1991 |
[Late results of immunosuppressive therapy in patients with heart failure and biopsy proven myocarditis].
Topics: Adult; Azathioprine; Female; Follow-Up Studies; Heart Failure; Humans; Immunosuppressive Agents; Mal | 1989 |
[Immunosuppressive treatment of chronic myocarditis].
Topics: Adolescent; Autoimmune Diseases; Azathioprine; Child; Child, Preschool; Chronic Disease; Drug Therap | 1988 |
Rejection of the transplanted human heart.
Topics: Antilymphocyte Serum; Azathioprine; Child, Preschool; Electrocardiography; Female; Heart Failure; He | 1969 |
Acute rejection following cardiac transplantation. Phonocardiographic and ultrasound observations.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Electrocardiography; Female; Heart Auscultation; Heart Fa | 1969 |
Coproporphyrinuria and heart transplantation: its significance.
Topics: Age Factors; Anemia, Hemolytic; Azathioprine; Chemical and Drug Induced Liver Injury; Electrocardiog | 1970 |
Surgical Grand Rounds from the University of Mississippi Medical Center. Renal transplantation.
Topics: Adult; Azathioprine; Consanguinity; Heart Failure; Humans; Hypertension, Malignant; Kidney Transplan | 1971 |
[3 cases of allogenic heart graft in man].
Topics: Adult; Angiocardiography; Azathioprine; Coronary Disease; Electrocardiography; Globulins; Heart Fail | 1969 |
[Anemia caused by erythroblastopenia in adult age].
Topics: Aged; Analgesics; Anemia, Aplastic; Azathioprine; Blood Transfusion; Female; Heart Failure; Hepatiti | 1970 |