azathioprine has been researched along with Carcinoma, Squamous Cell in 82 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent studies have reported a significant increase of proteinuria in kidney transplant recipients who were switched from a calcineurin inhibitor (CI) to sirolimus." | 9.12 | Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients. ( Hoitsma, AJ; van den Akker, JM; Wetzels, JF, 2006) |
| " A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone." | 7.75 | Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( Guenova, E; Hoetzenecker, W; Lichte, V; Moehrle, M; Roecken, M; Schaller, M; Woelbing, F, 2009) |
| "Recent studies have reported a significant increase of proteinuria in kidney transplant recipients who were switched from a calcineurin inhibitor (CI) to sirolimus." | 5.12 | Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients. ( Hoitsma, AJ; van den Akker, JM; Wetzels, JF, 2006) |
| " Warts (30%) had the larger incidence and were associated with azathioprine (P = 0." | 3.91 | Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients. ( Codarin, FR; Festa Neto, C; Oliveira, WRP; Silva, LLC; Souza, AAV; Tirico, MCCP, 2019) |
| "We assessed two patients with multiple sclerosis who were on treatment with dimethylfumarate (DMF) preceded by long-term azathioprine therapy." | 3.88 | Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. ( Bechara, FG; Gambichler, T; Hessam, S; Rüddel, I; Schmitz, L; Stockfleth, E, 2018) |
| "To investigate (i) whether loss of MMR protein expression and microsatellite instability are over-represented in squamous cell carcinomas (SCCs) from OTRs on azathioprine compared with SCCs from immunocompetent patients, and (ii) whether the MSH2 -6 exon 13 polymorphism is over-represented in OTRs with skin cancer on azathioprine." | 3.76 | Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients. ( Cerio, R; Harwood, CA; Karran, P; McGregor, JM; Perrett, CM; Warwick, J, 2010) |
| " A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone." | 3.75 | Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( Guenova, E; Hoetzenecker, W; Lichte, V; Moehrle, M; Roecken, M; Schaller, M; Woelbing, F, 2009) |
| "A prospective study in the United Kingdom of 1,634 patients without transplants treated with immunosuppressive drugs (68 percent with azathioprine, 28 percent with cyclophosphamide) found an excess of non-Hodgkin's lymphoma and squamous cell skin cancer, suggesting that the excesses (although larger) of the same malignancies found among transplant recipients are not due solely to the foreign antigens of the graft." | 3.67 | Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. ( Kinlen, LJ, 1985) |
| "However, the risk of acquiring skin cancer increases with the length of immunosuppressive therapy." | 2.67 | No difference in skin cancer incidence with or without cyclosporine--a 5-year perspective. ( Blohmé, I; Larkö, O, 1992) |
| "Excluding skin cancers, squamous cell carcinomas make up most head and neck cancers in transplant recipients." | 2.41 | Squamous cell carcinoma of the head and neck in solid organ transplant recipients. ( Adams, GL; Matas, A; Preciado, DA, 2002) |
| "Incident cases of non-melanoma skin cancers and non-Hodgkin lymphoma diagnosed after prescription of thiopurine and/or anti-tumor necrosis factor-α were identified between April 2008 and January 2018." | 1.56 | Lack of Increased Risk of Lymphoma by Thiopurines or Biologics in Japanese Patients with Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis. ( Hibi, T; Kobayashi, T; Uda, A; Udagawa, E, 2020) |
| "Two hundred thirty-one lip cancers were identified, corresponding to elevated risks for both invasive and in situ lip cancers (standardized incidence ratios of 15." | 1.51 | Risk of lip cancer after solid organ transplantation in the United States. ( Cahoon, EK; Copeland, G; Engels, EA; Gonsalves, L; Kahn, AR; Laprise, C; Lynch, CF; Madeleine, MM; Pfeiffer, RM, 2019) |
| "Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair)." | 1.48 | The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature. ( Alexandrov, LB; Chelala, C; Harwood, CA; Hogan, S; Inman, GJ; Leigh, IM; Nagano, A; Proby, CM; Purdie, KJ; Sherwood, V; South, AP; Spender, LC; Stratton, M; Taylor, RG; Thomson, J; Wang, J, 2018) |
| "Higher doses of azathioprine increase lip cancer risk, with implications for managing immunosuppressed populations and our understanding of the relationship between solar ultraviolet radiation and lip cancer." | 1.43 | High azathioprine dose and lip cancer risk in liver, heart, and lung transplant recipients: A population-based cohort study. ( Grulich, AE; Keogh, AM; Laaksonen, MA; McCaughan, GW; Meagher, NS; Na, R; Vajdic, CM, 2016) |
| "Treatment with azathioprine has been proven to increase the risk of non-melanoma skin cancer (NMSC) in transplant patients and possibly in patients with inflammatory bowel disease as well." | 1.40 | Increased incidence of squamous cell carcinoma of the skin after long-term treatment with azathioprine in patients with auto-immune inflammatory rheumatic diseases. ( de Jong, EM; Hendriks, JC; Janssen, M; Schers, HJ; Seyger, MM; van de Kerkhof, PC; van den Reek, JM; van Lümig, PP, 2014) |
| "The most common skin cancer in the population was squamous cell carcinoma." | 1.39 | Gene expression profiling for cardiac rejection surveillance is not predictive of post-transplantation skin cancer. ( Chen, H; Fang, F; Hanlon, A; Lott, J; O'Neill, M; Stasko, T; Wigger, M, 2013) |
| "Azathioprine (AZA) treatment in transplant or autoimmune patients and subsequent appearance squamous cell carcinomas at various sites, particularly skin and cervix, has shown a close relationship." | 1.38 | [A case of squamous cell carcinoma of the breast in a patient with Crohn's disease taking azathioprine]. ( Cho, JY; Heo, SW; Ju, DU; Kim, EJ; Kim, EY; Oh, HK; Park, KC; Ryu, JI, 2012) |
| "The risk of cutaneous squamous cell carcinoma (CSCC) is found to be substantially increased after organ transplantation." | 1.36 | Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma. ( Adami, J; Bellocco, R; Fernberg, P; Höglund, P; Ingvar, A; Lindelöf, B; Smedby, KE; Tufveson, G, 2010) |
| "The risk of skin cancer is highly increased in kidney-transplant recipients (KTR), but the risk of subsequent skin cancers is less well studied." | 1.36 | Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. ( Bavinck, JN; Claas, FH; de Fijter, JW; Edelbroek, JR; Haasnoot, GW; Willemze, R; Wisgerhof, HC, 2010) |
| "Squamous cell carcinoma was the most common malignant skin lesion and 84% of all lesions occurred in sun-exposed areas." | 1.33 | Skin cancer in renal allograft recipients--experience in different ethnic groups residing in the same geographical region. ( Gralla, J; Moosa, MR, 2005) |
| "The risk of posttransplant cutaneous squamous cell carcinoma in Norwegian heart transplant recipients (n = 148) and kidney transplant recipients (n = 1020) on triple immunosuppressive therapy with cyclosporine, azathioprine, and prednisolone, transplanted between 1983 and 1992, were studied." | 1.31 | Are heart transplant recipients more likely to develop skin cancer than kidney transplant recipients? ( Fauchald, P; Geiran, O; Gjersvik, P; Hansen, S; Leivestad, T; Møller, B; Pfeffer, P; Simonsen, S, 2000) |
| "Responses to treatment and disease progression were determined by comparing scores with baseline scores." | 1.31 | Oral lichen planus: patient profile, disease progression and treatment responses. ( Chainani-Wu, N; Lozada-Nur, F; Mayer, P; Silverman, S; Watson, JJ, 2001) |
| "The thrombocytopenia was diagnosed as idiopathic thrombocytopenic purpura." | 1.30 | [Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura]. ( Kariya, K; Kawamura, S; Munakata, A; Nakahata, R; Takami, H; Tamai, Y; Tsushima, K; Yoshimura, T, 1999) |
| "Endoscopic examination revealed esophageal cancer." | 1.29 | [Chronic myelomonocytic leukemia and esophageal cancer developed in a renal allograft recipient]. ( Fujita, N; Goto, H; Inaba, T; Itoh, K; Misawa, S; Murakami, S; Nakagawa, M; Oku, N; Shima, T; Shimazaki, C, 1993) |
| "The conjunctiva later became scarred with foreshortening of the fornices and development of symblepharon." | 1.28 | Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma. ( Folberg, R; Goeken, JA; Krachmer, JH; Lam, S; Massicotte, SJ; Smith, AC; Stone, MS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (31.71) | 18.7374 |
| 1990's | 13 (15.85) | 18.2507 |
| 2000's | 17 (20.73) | 29.6817 |
| 2010's | 25 (30.49) | 24.3611 |
| 2020's | 1 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, HG | 1 |
| Kuo, KY | 1 |
| Xiao, K | 1 |
| Batra, P | 1 |
| Li, S | 1 |
| Tang, JY | 1 |
| Sarin, KY | 1 |
| Gambichler, T | 1 |
| Rüddel, I | 1 |
| Hessam, S | 1 |
| Bechara, FG | 1 |
| Stockfleth, E | 2 |
| Schmitz, L | 1 |
| Vos, M | 1 |
| Plasmeijer, EI | 1 |
| van Bemmel, BC | 1 |
| van der Bij, W | 1 |
| Klaver, NS | 1 |
| Erasmus, ME | 1 |
| de Bock, GH | 1 |
| Verschuuren, EAM | 1 |
| Rácz, E | 1 |
| Laprise, C | 1 |
| Cahoon, EK | 1 |
| Lynch, CF | 1 |
| Kahn, AR | 1 |
| Copeland, G | 1 |
| Gonsalves, L | 1 |
| Madeleine, MM | 1 |
| Pfeiffer, RM | 1 |
| Engels, EA | 1 |
| Inman, GJ | 2 |
| Wang, J | 1 |
| Nagano, A | 1 |
| Alexandrov, LB | 1 |
| Purdie, KJ | 1 |
| Taylor, RG | 1 |
| Sherwood, V | 1 |
| Thomson, J | 1 |
| Hogan, S | 1 |
| Spender, LC | 1 |
| South, AP | 1 |
| Stratton, M | 1 |
| Chelala, C | 1 |
| Harwood, CA | 3 |
| Proby, CM | 2 |
| Leigh, IM | 3 |
| Oliveira, WRP | 1 |
| Tirico, MCCP | 1 |
| Souza, AAV | 1 |
| Codarin, FR | 1 |
| Silva, LLC | 1 |
| Festa Neto, C | 1 |
| Khan, N | 1 |
| Lee, H | 1 |
| Trivedi, C | 1 |
| Kavani, H | 1 |
| Medvedeva, E | 1 |
| Xie, D | 1 |
| Lewis, JD | 1 |
| Yang, YX | 1 |
| Singh, H | 1 |
| Bernstein, CN | 1 |
| Hanlon, A | 1 |
| O'Neill, M | 1 |
| Fang, F | 1 |
| Chen, H | 1 |
| Lott, J | 1 |
| Wigger, M | 1 |
| Stasko, T | 1 |
| Imko-Walczuk, B | 1 |
| Kryś, A | 1 |
| Lizakowski, S | 1 |
| Dębska-Ślizień, A | 1 |
| Rutkowski, B | 1 |
| Biernat, W | 1 |
| Wojnarowska, F | 1 |
| Kotze, PG | 1 |
| Zacharias, P | 1 |
| Na, R | 1 |
| Laaksonen, MA | 1 |
| Grulich, AE | 1 |
| Meagher, NS | 1 |
| McCaughan, GW | 1 |
| Keogh, AM | 1 |
| Vajdic, CM | 1 |
| Andrade, P | 1 |
| Lopes, S | 2 |
| Coelho, R | 1 |
| Terroso, G | 1 |
| Lage, J | 1 |
| Macedo, G | 2 |
| Batista, L | 1 |
| Zabana, Y | 1 |
| Aceituno, M | 1 |
| Esteve, M | 1 |
| Jiyad, Z | 1 |
| Olsen, CM | 1 |
| Burke, MT | 1 |
| Isbel, NM | 1 |
| Green, AC | 1 |
| Valenzuela, RM | 1 |
| Byrd, J | 1 |
| Kramer, GD | 1 |
| Palmer, CA | 1 |
| Osborn, AG | 1 |
| Digre, KB | 1 |
| Warner, JE | 1 |
| Wisgerhof, HC | 2 |
| Hameetman, L | 1 |
| Tensen, CP | 1 |
| Morreau, H | 1 |
| de Fijter, JW | 2 |
| Bouwes Bavinck, JN | 2 |
| Willemze, R | 3 |
| de Gruijl, FR | 2 |
| Guenova, E | 1 |
| Lichte, V | 1 |
| Hoetzenecker, W | 1 |
| Woelbing, F | 1 |
| Moehrle, M | 1 |
| Roecken, M | 1 |
| Schaller, M | 1 |
| Ingvar, A | 1 |
| Smedby, KE | 1 |
| Lindelöf, B | 1 |
| Fernberg, P | 1 |
| Bellocco, R | 1 |
| Tufveson, G | 1 |
| Höglund, P | 1 |
| Adami, J | 1 |
| Perrett, CM | 1 |
| McGregor, JM | 1 |
| Warwick, J | 1 |
| Cerio, R | 1 |
| Karran, P | 1 |
| Edelbroek, JR | 1 |
| Haasnoot, GW | 1 |
| Claas, FH | 1 |
| Bavinck, JN | 1 |
| Vilas-Boas, F | 1 |
| Magro, F | 1 |
| Balhau, R | 1 |
| Lopes, JM | 1 |
| Beça, F | 1 |
| Eloy, C | 1 |
| Wagner, JA | 1 |
| van den Reek, JM | 1 |
| van Lümig, PP | 1 |
| Janssen, M | 1 |
| Schers, HJ | 1 |
| Hendriks, JC | 1 |
| van de Kerkhof, PC | 1 |
| Seyger, MM | 1 |
| de Jong, EM | 1 |
| Carroll, RP | 1 |
| Hester, J | 1 |
| Wood, KJ | 1 |
| Harden, PN | 1 |
| Park, KC | 1 |
| Ju, DU | 1 |
| Heo, SW | 1 |
| Ryu, JI | 1 |
| Cho, JY | 1 |
| Kim, EJ | 1 |
| Oh, HK | 1 |
| Kim, EY | 1 |
| Alvarez Delgado, A | 1 |
| Pérez García, ML | 1 |
| Fradejas Salazar, PM | 1 |
| de la Coba Ortíz, C | 1 |
| Rodríguez Pérez, A | 1 |
| Botsios, C | 1 |
| Ostuni, P | 1 |
| Boscolo-Rizzo, P | 1 |
| Da Mosto, MC | 1 |
| Punzi, L | 1 |
| Marchiori, C | 1 |
| Crovetto, M | 1 |
| Solano, D | 1 |
| Centeno, J | 1 |
| Moosa, MR | 1 |
| Gralla, J | 1 |
| Parrish, JA | 1 |
| van den Akker, JM | 1 |
| Wetzels, JF | 1 |
| Hoitsma, AJ | 1 |
| Ulrich, C | 1 |
| Nair, B | 1 |
| Sukumar, S | 1 |
| Poolari, GK | 1 |
| Appu, T | 1 |
| Cooke, MS | 1 |
| Osborne, JE | 1 |
| Singh, R | 1 |
| Mistry, V | 1 |
| Farmer, PB | 1 |
| Evans, MD | 1 |
| Hutchinson, PE | 1 |
| de Graaf, YG | 1 |
| Rebel, H | 1 |
| Elghalbzouri, A | 1 |
| Cramers, P | 1 |
| Nellen, RG | 1 |
| Cohen, SM | 1 |
| Erturk, E | 1 |
| Skibba, JL | 1 |
| Bryan, GT | 1 |
| Euvrard, S | 1 |
| Kanitakis, J | 1 |
| Pouteil-Noble, C | 1 |
| Disant, F | 1 |
| Dureau, G | 1 |
| Finaz de Villaine, J | 1 |
| Claudy, A | 1 |
| Thivolet, J | 1 |
| Nachbar, F | 1 |
| Stolz, W | 1 |
| Volkenandt, M | 1 |
| Meurer, M | 1 |
| Shima, T | 1 |
| Oku, N | 1 |
| Goto, H | 1 |
| Inaba, T | 1 |
| Murakami, S | 1 |
| Itoh, K | 1 |
| Fujita, N | 1 |
| Shimazaki, C | 1 |
| Misawa, S | 1 |
| Nakagawa, M | 1 |
| Bottomley, WW | 1 |
| Ford, G | 1 |
| Cunliffe, WJ | 1 |
| Cotterill, JA | 1 |
| Glover, MT | 1 |
| Deeks, JJ | 1 |
| Raftery, MJ | 1 |
| Cunningham, J | 1 |
| Volgger, B | 1 |
| Marth, C | 1 |
| Zeimet, A | 1 |
| Müller-Holzner, E | 1 |
| Ruth, N | 1 |
| Dapunt, O | 1 |
| Veness, MJ | 1 |
| Yoshimura, T | 1 |
| Tamai, Y | 1 |
| Takami, H | 1 |
| Kariya, K | 1 |
| Nakahata, R | 1 |
| Tsushima, K | 1 |
| Munakata, A | 1 |
| Kawamura, S | 1 |
| Caforio, AL | 1 |
| Fortina, AB | 1 |
| Piaserico, S | 1 |
| Alaibac, M | 1 |
| Tona, F | 1 |
| Feltrin, G | 1 |
| Pompei, E | 1 |
| Testolin, L | 1 |
| Gambino, A | 1 |
| Volta, SD | 1 |
| Thiene, G | 1 |
| Casarotto, D | 1 |
| Peserico, A | 1 |
| Gjersvik, P | 1 |
| Hansen, S | 1 |
| Møller, B | 1 |
| Leivestad, T | 1 |
| Geiran, O | 1 |
| Simonsen, S | 1 |
| Pfeffer, P | 1 |
| Fauchald, P | 1 |
| López-Cepero Andrada, JM | 1 |
| Ferré Alamo, A | 1 |
| López Silva, M | 1 |
| Salado Fuentes, M | 1 |
| Benítez Roldán, A | 1 |
| Chainani-Wu, N | 1 |
| Silverman, S | 1 |
| Lozada-Nur, F | 1 |
| Mayer, P | 1 |
| Watson, JJ | 1 |
| Preciado, DA | 1 |
| Matas, A | 1 |
| Adams, GL | 1 |
| Sterioff, S | 1 |
| Rios, CN | 1 |
| Zachary, JB | 1 |
| Williams, GM | 1 |
| Symington, GR | 1 |
| Mackay, IR | 1 |
| Lambert, RP | 1 |
| Jacobs, SC | 1 |
| McLaughlin, AP | 1 |
| Gittes, RF | 1 |
| Bowen-Simpkins, P | 2 |
| Hull, MG | 2 |
| Koranda, FC | 2 |
| Loeffler, RT | 1 |
| Koranda, DM | 1 |
| Penn, I | 2 |
| Cohen, LM | 1 |
| Tyring, SK | 1 |
| Rády, P | 1 |
| Callen, JP | 1 |
| McCain, J | 1 |
| Blohmé, I | 1 |
| Larkö, O | 1 |
| Regev, E | 1 |
| Zeltser, R | 1 |
| Lustmann, J | 1 |
| Lam, S | 1 |
| Stone, MS | 1 |
| Goeken, JA | 1 |
| Massicotte, SJ | 1 |
| Smith, AC | 1 |
| Folberg, R | 1 |
| Krachmer, JH | 1 |
| Choy, DS | 1 |
| Gearhart, RP | 1 |
| Gould, WJ | 1 |
| Sauer, J | 1 |
| Jacobson, L | 1 |
| Rosenthal, B | 1 |
| Xerri, L | 1 |
| Payan, MJ | 1 |
| Choux, R | 1 |
| Gros, N | 1 |
| Hassoun, J | 1 |
| Chamlian, A | 1 |
| Blin, D | 1 |
| Monties, JR | 1 |
| Ashinoff, R | 1 |
| Werth, VP | 1 |
| Franks, AG | 1 |
| Sheil, AG | 1 |
| Flavel, S | 1 |
| Disney, AP | 1 |
| Mathew, TH | 1 |
| Hall, BM | 1 |
| Pace-Balzan, A | 1 |
| Timms, MS | 1 |
| Reeve, VE | 1 |
| Greenoak, GE | 1 |
| Gallagher, CH | 1 |
| Canfield, PJ | 1 |
| Wilkinson, FJ | 1 |
| Lennard, L | 1 |
| Thomas, S | 1 |
| Harrington, CI | 1 |
| Maddocks, JL | 1 |
| Kinlen, LJ | 1 |
| Jacobsson, S | 1 |
| Linell, F | 1 |
| Rausing, A | 1 |
| Walder, BK | 1 |
| Robertson, MR | 1 |
| Jeremy, D | 1 |
| Murray, JE | 1 |
| Wilson, RE | 1 |
| Tilney, NL | 1 |
| Merrill, JP | 1 |
| Cooper, WC | 1 |
| Birtch, AG | 1 |
| Carpenter, CB | 1 |
| Hager, EB | 1 |
| Dammin, GJ | 1 |
| Harrison, JH | 1 |
| Dehmel, EM | 1 |
| Kahn, G | 1 |
| Jalota, R | 1 |
| Eichwald, EJ | 1 |
| Westburg, SP | 1 |
| Stone, OJ | 1 |
| Marshall, V | 1 |
| Donohue, LR | 1 |
| Marshall, VC | 1 |
| Lowney, ED | 1 |
| Sheehan, R | 1 |
| Shklar, G | 1 |
| Tennenbaum, R | 1 |
| Kobayashi, T | 1 |
| Uda, A | 1 |
| Udagawa, E | 1 |
| Hibi, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Ginger Muco-bioadhesive Gel in Management of Oral Lichen Planus: A Randomized Controlled Clinical Trial With Immunohistochemical Analysis[NCT05882864] | Phase 4 | 28 participants (Anticipated) | Interventional | 2023-08-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for azathioprine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Graft Rejection; Humans; Immunosuppre | 2016 |
Oral squamous cell carcinoma in a Crohn's disease patient taking azathioprine: case report and review of the literature.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Crohn Disease; Female; Humans; Immunosuppressive Agen | 2012 |
Azathioprine, UV light, and skin cancer in organ transplant patients--do we have an answer?
Topics: Azathioprine; Carcinoma, Squamous Cell; Humans; Immunosuppressive Agents; Kidney Transplantation; My | 2007 |
Squamous cell carcinoma of the head and neck in solid organ transplant recipients.
Topics: Anti-Inflammatory Agents; Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Head and Neck Neopla | 2002 |
Lip carcinoma in renal allograft recipient with long-term immunosuppressive therapy.
Topics: Adult; Atenolol; Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Female; Humans; Immunosuppres | 1992 |
Development of multiple carcinomas in a long term survivor of Wegener's granulomatosis treated with immunosuppressive drugs.
Topics: Adult; Azathioprine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Gran | 1989 |
Colposcopic and cytologic evaluation of women undergoing immunosuppressive therapy.
Topics: Antigens, Neoplasm; Azathioprine; Carcinoma in Situ; Carcinoma, Squamous Cell; Colposcopy; Female; G | 1974 |
3 trials available for azathioprine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Conversion to sirolimus in kidney transplant recipients with squamous cell cancer and changes in immune phenotype.
Topics: Aged; Aged, 80 and over; Azathioprine; Calcineurin Inhibitors; Carcinoma, Squamous Cell; CD56 Antige | 2013 |
Proteinuria following conversion from azathioprine to sirolimus in renal transplant recipients.
Topics: Aged; Azathioprine; Calcineurin Inhibitors; Carcinoma, Squamous Cell; Creatinine; Female; Follow-Up | 2006 |
No difference in skin cancer incidence with or without cyclosporine--a 5-year perspective.
Topics: Azathioprine; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclosporine; Foll | 1992 |
72 other studies available for azathioprine and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Azathioprine and risk of multiple keratinocyte cancers.
Topics: Aged; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; | 2018 |
Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery.
Topics: 5-Methylcytosine; Azathioprine; Carcinoma, Squamous Cell; Cell Cycle; Cyclin-Dependent Kinase Inhibi | 2018 |
Azathioprine to mycophenolate mofetil transition and risk of squamous cell carcinoma after lung transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Carcinoma, Squamous Cell; Child; Drug Substitution; Female; H | 2018 |
Risk of lip cancer after solid organ transplantation in the United States.
Topics: Adolescent; Adult; Aged; Azathioprine; Carcinoma, Squamous Cell; Child; Child, Preschool; Cyclospori | 2019 |
The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.
Topics: 3T3 Cells; Animals; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, | 2018 |
Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Brazil; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chil | 2019 |
Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Diseases Receiving Treatment With Thiopurines.
Topics: Aged; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Female; Follow-Up Studies; Humans; Immunosuppr | 2019 |
Azathioprine: friend or foe?
Topics: Azathioprine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Germ-Line Mutation; Humans; Immunosuppres | 2019 |
Sorting Through the Risks and Benefits of Thiopurine Therapy for Inflammatory Bowel Diseases.
Topics: Azathioprine; Carcinoma, Squamous Cell; Humans; Inflammatory Bowel Diseases; Risk Assessment | 2019 |
Gene expression profiling for cardiac rejection surveillance is not predictive of post-transplantation skin cancer.
Topics: Adult; Aged; Azathioprine; Carcinoma, Squamous Cell; Gene Expression; Gene Expression Profiling; Gra | 2013 |
Sebaceous carcinoma in patients receiving long-term immunosuppresive treatment: case report and literature review.
Topics: Aged, 80 and over; Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Fatal Outcome; Female; Huma | 2014 |
Anal Squamous Cell Carcinoma: An Infrequent Challenge in the Management of Ulcerative Colitis Under Combination Therapy.
Topics: Aged; Anti-Inflammatory Agents; Anus Neoplasms; Azathioprine; Carcinoma, Squamous Cell; Colitis, Ulc | 2016 |
High azathioprine dose and lip cancer risk in liver, heart, and lung transplant recipients: A population-based cohort study.
Topics: Adult; Age Factors; Australia; Azathioprine; Carcinoma, Squamous Cell; Heart Transplantation; Humans | 2016 |
Squamous cell carcinoma arising from a presacral cyst in a patient with ulcerative colitis under azathioprine and infliximab: first case report.
Topics: Azathioprine; Carcinoma, Squamous Cell; Colitis, Ulcerative; Cysts; Female; Humans; Infliximab; Midd | 2016 |
Men in the spotlight: A rare case of penile squamous carcinoma associated with human papillomavirus (HPV) infection in a patient with ulcerative colitis (UC).
Topics: Aged; Azathioprine; Carcinoma, Squamous Cell; Colitis, Ulcerative; Human papillomavirus 16; Human pa | 2016 |
An 82-Year-Old Man With Diplopia.
Topics: Aged, 80 and over; Azathioprine; Carcinoma, Squamous Cell; Cranial Nerve Neoplasms; Diplopia; Drug T | 2016 |
Azathioprine-induced microsatellite instability is not observed in skin carcinomas of organ transplant recipients.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; DNA, Neoplasm; Graft Rejection; Human | 2009 |
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Topics: Aged; Antineoplastic Agents, Alkylating; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Ce | 2009 |
Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma.
Topics: Adolescent; Adult; Aged; Azathioprine; Carcinoma, Squamous Cell; Case-Control Studies; Child; Cohort | 2010 |
Expression of DNA mismatch repair proteins and MSH2 polymorphisms in nonmelanoma skin cancers of organ transplant recipients.
Topics: Adaptor Proteins, Signal Transducing; Azathioprine; Base Pair Mismatch; Biomarkers, Tumor; Carcinoma | 2010 |
Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Immunosuppressive Age | 2010 |
Cancer after heart transplant: implications for practice.
Topics: Azathioprine; Carcinoma, Squamous Cell; Drug Therapy, Combination; Fatal Outcome; Glucocorticoids; H | 2012 |
Increased incidence of squamous cell carcinoma of the skin after long-term treatment with azathioprine in patients with auto-immune inflammatory rheumatic diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Squamous | 2014 |
[A case of squamous cell carcinoma of the breast in a patient with Crohn's disease taking azathioprine].
Topics: Adult; Azathioprine; Breast Neoplasms; Carcinoma, Squamous Cell; Colonoscopy; Combined Modality Ther | 2012 |
[Invasive cancer of the cervix in a patient undergoing chronic treatment with 6-mercaptopurine for Crohns disease].
Topics: Aged; Azathioprine; Carcinoma, Squamous Cell; Crohn Disease; Fatal Outcome; Female; Humans; Immunosu | 2003 |
Dermatomyositis and malignancy of the pharynx in Caucasian patients: report of two observations.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Carcinoma, Squamous Cell; Combin | 2003 |
[Recurrent polychondritis: apropos of a case].
Topics: Aspirin; Autoimmune Diseases; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Conjunctivitis; Cyclos | 2003 |
Skin cancer in renal allograft recipients--experience in different ethnic groups residing in the same geographical region.
Topics: Adult; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclosporine; Female; Humans; | 2005 |
Immunosuppression, skin cancer, and ultraviolet A radiation.
Topics: Azathioprine; Carcinoma, Squamous Cell; DNA Damage; Humans; Immunosuppression Therapy; Immunosuppres | 2005 |
Azathioprine-induced squamous cell carcinoma of the kidney.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Humans; Immunosuppressive Agents; Kidney Neoplasms; M | 2007 |
Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Azathioprine; Carcinoma, Squamous Cell; Case-Control Studies; Deoxyguan | 2007 |
More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine.
Topics: Adult; Aged; Animals; Azathioprine; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Clone | 2008 |
Azathioprine induction of lymphomas and squamous cell carcinomas in rats.
Topics: Animals; Azathioprine; Carcinoma, Squamous Cell; Ear Neoplasms; Female; Lymphoma; Rats; Rats, Inbred | 1983 |
Aggressive squamous cell carcinomas in organ transplant recipients.
Topics: Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Heart Transplantation; Humans; Immunosuppressi | 1995 |
Squamous cell carcinoma in localized scleroderma following immunosuppressive therapy with azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Humans; Male; Risk Factors; Scleroderma, Localized; S | 1993 |
[Chronic myelomonocytic leukemia and esophageal cancer developed in a renal allograft recipient].
Topics: Azathioprine; Carcinoma, Squamous Cell; Esophageal Neoplasms; Humans; Immunosuppression Therapy; Kid | 1993 |
Aggressive squamous cell carcinomas developing in patients receiving long-term azathioprine.
Topics: Aged; Azathioprine; Carcinoma, Squamous Cell; Cocarcinogenesis; Ear Neoplasms; Head and Neck Neoplas | 1995 |
Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients.
Topics: Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Drug Therapy, Combination; Follow-Up Studies; | 1997 |
Fulminant course of a microinvasive vulvar carcinoma in an immunosuppressed woman.
Topics: Adult; Azathioprine; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; Condylomata Acuminata | 1997 |
Cardiac transplant-related cutaneous malignancies in an Australian recipient: immunosuppression, friend or foe?
Topics: Adult; Australia; Azathioprine; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cy | 1998 |
[Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura].
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunosuppressiv | 1999 |
Skin cancer in heart transplant recipients: risk factor analysis and relevance of immunosuppressive therapy.
Topics: Age Distribution; Azathioprine; Carcinoma, Squamous Cell; Comorbidity; Cyclosporine; Drug Therapy, C | 2000 |
Are heart transplant recipients more likely to develop skin cancer than kidney transplant recipients?
Topics: Azathioprine; Carcinoma, Squamous Cell; Cyclosporine; Drug Therapy, Combination; Heart Transplantati | 2000 |
[Azathioprine and cavum carcinoma in a patient with autoimmune hepatitis and Crohn's disease].
Topics: Azathioprine; Carcinoma, Squamous Cell; Crohn Disease; Head and Neck Neoplasms; Hepatitis, Autoimmun | 2001 |
Oral lichen planus: patient profile, disease progression and treatment responses.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Carcinoma, Squamous Ce | 2001 |
Neoplasia in kidney transplant recipients.
Topics: Adult; Azathioprine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Female; Huma | 1975 |
Cancer and teratogenesis: infrequent occurrence after medical use of immunosuppressive drugs.
Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous C | 1977 |
Effects of immunosuppression on the rejection of methylcholanthrene tumor isografts.
Topics: Animals; Antigens, Neoplasm; Azathioprine; Carcinoma, Squamous Cell; Graft Rejection; Immunosuppress | 1977 |
Intraepithelial vaginal neoplasia following immunosuppressive therapy treated with topical 5-Fu.
Topics: Administration, Topical; Adult; Azathioprine; Biopsy; Carcinoma, Squamous Cell; Cervix Uteri; Female | 1975 |
Accelerated induction of skin cancers by ultraviolet radiation in hairless mice treated with immunosuppressive agents.
Topics: Animals; Azathioprine; Carcinoma, Squamous Cell; Female; Mice; Mice, Nude; Prednisone; Skin Neoplasm | 1975 |
Human papillomavirus type 11 in multiple squamous cell carcinomas in a patient with subacute cutaneous lupus erythematosus.
Topics: Acute Disease; Azathioprine; Carcinoma, Squamous Cell; Cocarcinogenesis; Humans; Lupus Erythematosus | 1992 |
Living on borrowed time.
Topics: Attitude to Health; Azathioprine; Carcinoma, Squamous Cell; Heart Transplantation; Humans; Male; Nur | 1992 |
Paraneoplastic pemphigus, cicatricial conjunctivitis, and acanthosis nigricans with pachydermatoglyphy in a patient with bronchogenic squamous cell carcinoma.
Topics: Acanthosis Nigricans; Aged; Azathioprine; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chronic | 1992 |
An exceptional 18-year follow-up after cardiac transplantation. How can malignancies occur during immunosuppressive therapy?
Topics: Adenocarcinoma, Papillary; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Follow-Up | 1989 |
Resistant discoid lupus erythematosus of palms and soles: successful treatment with azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Drug Resistance; Female; Foot Dermatoses; Hand Dermat | 1988 |
Cancer incidence in renal transplant patients treated with azathioprine or cyclosporine.
Topics: Australia; Azathioprine; Carcinoma, Squamous Cell; Cyclosporins; Female; Humans; Kidney Transplantat | 1987 |
Intranasal squamous cell carcinoma in a renal transplant recipient on long term immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Female; Humans; Immunosuppressive Agents; Kidney Tran | 1987 |
Effect of immunosuppressive agents and sunscreens on UV carcinogenesis in the hairless mouse.
Topics: 4-Aminobenzoic Acid; Animals; Antibody Formation; Azathioprine; Carcinoma in Situ; Carcinoma, Squamo | 1985 |
Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Drug Administration Schedule; Erythrocytes; Female; G | 1985 |
Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squa | 1985 |
Florid keratoacanthomas in a kidney transplant recipient. Case report.
Topics: Azathioprine; Carcinoma, Squamous Cell; Dactinomycin; Graft Rejection; Humans; Immunosuppression The | 1974 |
Skin cancer and immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Immunosuppress | 1971 |
Five years' experience in renal transplantation with immunosuppressive drugs: survival, function, complications, and the role of lymphocyte depletion by thoracic duct fistula.
Topics: Azaserine; Azathioprine; Cadaver; Carcinoma, Squamous Cell; Dactinomycin; Female; Fistula; Humans; H | 1968 |
Cutaneous complications in immunosuppressed renal homograft recipients.
Topics: Acne Vulgaris; Adolescent; Adult; Alopecia; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous | 1974 |
Chronic immunosuppression and occult lymphoma: a case report.
Topics: Adult; Azathioprine; Bone Neoplasms; Cadaver; Carcinoma, Squamous Cell; Cytomegalovirus Infections; | 1972 |
Multiple cutaneous squamous cell carcinomas during immunosuppressive therapy.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Fluorouracil; Humans; Hyperplasia; Immunosuppressive | 1973 |
Premalignant and malignant skin tumours in immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Cadaver; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyc | 1974 |
Skin tumours in immunosuppressed patients.
Topics: Adolescent; Adult; Allopurinol; Antineoplastic Agents; Azathioprine; Carcinoma, Basal Cell; Carcinom | 1973 |
Intra-epithelial carcinoma of the vagina following immunosuppression treated with topical 5-fluorouracil.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Prednisolone; Vaginal N | 1974 |
Antimitotic drugs and aggressive squamous cell tumors.
Topics: Aged; Antineoplastic Agents; Azathioprine; Carcinoma, Squamous Cell; Cyclophosphamide; Humans; Kerat | 1972 |
Azathioprine effects on the development of hamster pouch carcinomas.
Topics: Animals; Azathioprine; Benz(a)Anthracenes; Carcinoma, Squamous Cell | 1971 |
Lack of Increased Risk of Lymphoma by Thiopurines or Biologics in Japanese Patients with Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis.
Topics: Adalimumab; Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colitis, Ulcerative; Crohn | 2020 |