azathioprine has been researched along with Carcinoma, Merkel Cell in 4 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cases of Merkel cell carcinoma have become increasingly more common in the last two decades, and its incidence has been predicted to climb further." | 1.51 | Inferior outcomes in immunocompromised Merkel cell carcinoma patients: Can they be overcome by the use of PD1/PDL1 inhibitors? ( Codreanu, I; Dasanu, CA; Del Rosario, M; Hyams, DM; Plaxe, SC, 2019) |
| "Azathioprine and cyclosporin have been used as immunosuppressants for many years, but long-term use has also been associated with neoplasia." | 1.30 | Merkel cell carcinoma arising after therapeutic immunosuppression. ( Bunker, CB; Gooptu, C; Morris, PJ; Price, M; Ross, J; Wall, S; Wojnarowska, F; Woollons, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dasanu, CA | 1 |
| Del Rosario, M | 1 |
| Codreanu, I | 1 |
| Hyams, DM | 1 |
| Plaxe, SC | 1 |
| Clarke, CA | 1 |
| Robbins, HA | 1 |
| Tatalovich, Z | 1 |
| Lynch, CF | 1 |
| Pawlish, KS | 1 |
| Finch, JL | 1 |
| Hernandez, BY | 1 |
| Fraumeni, JF | 1 |
| Madeleine, MM | 1 |
| Engels, EA | 1 |
| Muirhead, R | 1 |
| Ritchie, DM | 1 |
| Gooptu, C | 1 |
| Woollons, A | 1 |
| Ross, J | 1 |
| Price, M | 1 |
| Wojnarowska, F | 1 |
| Morris, PJ | 1 |
| Wall, S | 1 |
| Bunker, CB | 1 |
4 other studies available for azathioprine and Carcinoma, Merkel Cell
| Article | Year |
|---|---|
Inferior outcomes in immunocompromised Merkel cell carcinoma patients: Can they be overcome by the use of PD1/PDL1 inhibitors?
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic A | 2019 |
Risk of merkel cell carcinoma after solid organ transplantation.
Topics: Adult; Aged; Azathioprine; Carcinoma, Merkel Cell; Cyclosporine; Female; Humans; Immunocompromised H | 2015 |
Partial regression of Merkel cell carcinoma in response to withdrawal of azathioprine in an immunosuppression-induced case of metastatic Merkel cell carcinoma.
Topics: Azathioprine; Carcinoma, Merkel Cell; Fatal Outcome; Head and Neck Neoplasms; Humans; Immunocompromi | 2007 |
Merkel cell carcinoma arising after therapeutic immunosuppression.
Topics: Aged; Azathioprine; Carcinoma, Merkel Cell; Cyclosporine; Female; Humans; Immunocompromised Host; Im | 1997 |