azathioprine has been researched along with Carcinoma, Hepatocellular in 41 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 7.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 5.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis." | 5.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Reported herein is a case of hepatocellular carcinoma (HCC) occurring in a 25-year-old Japanese man who was diagnosed with Crohn's disease (CD) at 14 years of age; treatment included predonisolone, azathioprine, and infliximab." | 3.75 | Hepatocellular carcinoma occurring in a young Crohn's disease patient. ( Enaka, M; Kawachi, K; Kunisaki, R; Morimoto, M; Murakami, A; Nagano, Y; Nozawa, A; Sasaki, T; Tanabe, M; Tanaka, Y; Ueda, M, 2009) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 3.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) was recognized as a new disease entity; however, IgG4-associated de novo AIH after the liver transplantation had not been reported yet." | 2.49 | Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review. ( Jia, JD; Rakhda, MI; Wang, TI; Zhao, XY, 2013) |
| " Adequately dosed steroids are the mainstay of remission induction treatment, while remission maintenance is best achieved by azathioprine." | 2.47 | Autoimmune hepatitis. ( Lohse, AW; Mieli-Vergani, G, 2011) |
| "In fact, it is expected that cancer will surpass cardiovascular complications as the leading cause of death in transplant patients within the next 2 decades." | 2.43 | Malignancy after transplantation. ( Buell, JF; Gross, TG; Woodle, ES, 2005) |
| "Ascites, variceal bleeding, and hepatocellular carcinoma were found in 1." | 1.46 | Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. ( Choi, HY; Jang, ES; Jeong, SH; Ki, M; Kim, BH; Kim, KA, 2017) |
| "The development of hepatocellular carcinoma (HCC) is attributed to several factors, including chronic viral infection, alcohol consumption, exposure to aflatoxin B1 and metabolic disorders." | 1.37 | Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease. ( Cui, DJ; Ouyang, Q; Zheng, SM, 2011) |
| "Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 °C incubator with 5% CO₂." | 1.37 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma. ( Cuevas, EP; Díaz-Laviada, I; Fernández-Moreno, MD; Gisbert, JP; Guijarro, LG; Hernández-Breijo, B; Monserrat, J; Ramírez-Rubio, S; Román, ID; Vara, D, 2011) |
| "We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients." | 1.36 | Hepatocellular carcinoma occurring in a Crohn's disease patient. ( Andoh, A; Fujiyama, Y; Hotta, M; Ishida, M; Kojima, F; Kurumi, Y; Naka, S; Nakahara, T; Okabe, H; Saito, Y; Shiomi, H; Takikita-Suzuki, M; Tani, T; Tsujikawa, T, 2010) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 1.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis." | 1.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Although the prognosis of type 1 autoimmune hepatitis is generally good with immunosuppressive treatment, the disease progresses in some patients despite the treatment." | 1.33 | Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis. ( Ikeda, H; Iwasaki, Y; Kobashi, H; Makino, Y; Miyake, Y; Okamaoto, R; Sakaguchi, K; Shiratori, Y; Takaguchi, K; Terada, R, 2006) |
| "The occurrence of hepatocellular carcinoma (HCC) in renal transplant recipients has typically been associated with hepatitis B or C infection." | 1.30 | Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series. ( Adams, MB; Franco, J; Komorowski, RA; Saeian, K, 1999) |
| " There was no increase in concurrent immunosuppressives dosage after the conversion." | 1.29 | Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation. ( Kaplan, MM; Pedrosa, MC; Rohrer, RM, 1995) |
| "Later, primary hepatocellular carcinoma assumes increasing importance." | 1.25 | Viral hepatitis and cirrhosis. ( Sherlock, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (48.78) | 18.7374 |
| 1990's | 3 (7.32) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 8 (19.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, BH | 1 |
| Choi, HY | 1 |
| Ki, M | 1 |
| Kim, KA | 1 |
| Jang, ES | 1 |
| Jeong, SH | 1 |
| Zhao, XY | 1 |
| Rakhda, MI | 1 |
| Wang, TI | 1 |
| Jia, JD | 1 |
| Rodríguez-Perálvarez, M | 1 |
| De la Mata, M | 1 |
| Burroughs, AK | 1 |
| Apostolidis, L | 1 |
| Kahlert, C | 1 |
| Siegmund, A | 1 |
| Thom, R | 1 |
| Horstmann, S | 1 |
| Jäger, D | 1 |
| Lordick, F | 1 |
| Maggs, J | 1 |
| Cullen, S | 1 |
| Krok, KL | 1 |
| Munoz, SJ | 1 |
| Murakami, A | 1 |
| Tanaka, Y | 1 |
| Ueda, M | 1 |
| Nagano, Y | 1 |
| Kunisaki, R | 1 |
| Morimoto, M | 1 |
| Enaka, M | 1 |
| Tanabe, M | 1 |
| Kawachi, K | 1 |
| Sasaki, T | 1 |
| Nozawa, A | 1 |
| Ishida, M | 1 |
| Naka, S | 1 |
| Shiomi, H | 1 |
| Tsujikawa, T | 1 |
| Andoh, A | 1 |
| Nakahara, T | 1 |
| Saito, Y | 1 |
| Kurumi, Y | 1 |
| Takikita-Suzuki, M | 1 |
| Kojima, F | 1 |
| Hotta, M | 1 |
| Tani, T | 1 |
| Fujiyama, Y | 1 |
| Okabe, H | 1 |
| Lohse, AW | 1 |
| Mieli-Vergani, G | 1 |
| Zheng, SM | 1 |
| Cui, DJ | 1 |
| Ouyang, Q | 1 |
| Hernández-Breijo, B | 1 |
| Monserrat, J | 1 |
| Ramírez-Rubio, S | 1 |
| Cuevas, EP | 1 |
| Vara, D | 1 |
| Díaz-Laviada, I | 1 |
| Fernández-Moreno, MD | 1 |
| Román, ID | 1 |
| Gisbert, JP | 1 |
| Guijarro, LG | 1 |
| Hino-Arinaga, T | 1 |
| Ide, T | 1 |
| Kuromatsu, R | 1 |
| Miyajima, I | 1 |
| Ogata, K | 1 |
| Kuwahara, R | 1 |
| Hisamochi, A | 1 |
| Torimura, T | 1 |
| Sata, M | 1 |
| Buell, JF | 1 |
| Gross, TG | 1 |
| Woodle, ES | 1 |
| Chen, SC | 1 |
| Cummings, OW | 1 |
| Hartley, MP | 1 |
| Filomena, CA | 1 |
| Cho, WK | 1 |
| Miyake, Y | 1 |
| Iwasaki, Y | 1 |
| Terada, R | 1 |
| Okamaoto, R | 1 |
| Ikeda, H | 1 |
| Makino, Y | 1 |
| Kobashi, H | 1 |
| Takaguchi, K | 1 |
| Sakaguchi, K | 1 |
| Shiratori, Y | 1 |
| Samarasena, J | 1 |
| Borgaonkar, M | 1 |
| Calne, R | 1 |
| Lee, FL | 1 |
| Murray, SM | 1 |
| Prior, J | 1 |
| Shreeve, DR | 1 |
| Pedrosa, MC | 1 |
| Rohrer, RM | 1 |
| Kaplan, MM | 1 |
| Konstantinov, BA | 1 |
| Eramishantsev, AK | 1 |
| Goté, SV | 1 |
| Tsirulńikova, OM | 1 |
| Skipenko, OG | 1 |
| Lebezev, VM | 1 |
| Shertsinger, AG | 1 |
| Lokshin, LS | 1 |
| Saeian, K | 1 |
| Franco, J | 1 |
| Komorowski, RA | 1 |
| Adams, MB | 1 |
| Cattan, S | 1 |
| Wendum, D | 1 |
| Chazouilleres, O | 1 |
| Schmitz, J | 1 |
| Gendre, JP | 1 |
| Russmann, S | 1 |
| Zimmermann, A | 1 |
| Krähenbühl, S | 1 |
| Kern, B | 1 |
| Reichen, J | 1 |
| Sherlock, S | 1 |
| O'Grady, JG | 1 |
| Johnson, PJ | 1 |
| Zaman, S | 1 |
| Calne, RY | 2 |
| Williams, R | 3 |
| Gruber, S | 1 |
| Dehner, LP | 1 |
| Simmons, RL | 1 |
| Alpert, E | 1 |
| Starzl, TE | 3 |
| Schur, PH | 1 |
| Isselbacher, KJ | 1 |
| Smith, MG | 2 |
| Doniach, D | 1 |
| Porter, KA | 1 |
| Brettschneider, L | 3 |
| Penn, I | 3 |
| Bell, P | 2 |
| Putnam, CW | 3 |
| McGuire, RL | 1 |
| Gütgemann, A | 3 |
| Schriefers, KH | 2 |
| Esser, G | 2 |
| Lee, TS | 1 |
| Paquet, KJ | 2 |
| Käufer, C | 3 |
| Lie, TS | 2 |
| Fortner, JG | 1 |
| Shiu, MH | 1 |
| Balner, H | 1 |
| Wilson, CB | 1 |
| Sichuk, G | 1 |
| Kawano, N | 1 |
| Holmes, JT | 1 |
| Beattie, EJ | 1 |
| Groth, CG | 1 |
| Blanchard, H | 1 |
| Kashiwagi, N | 1 |
| Starzi, TE | 1 |
| Giles, G | 1 |
| Picache, R | 1 |
| Prejean, JD | 1 |
| Griswold, DP | 1 |
| Weisburger, JH | 1 |
| Birtch, AG | 1 |
| Moore, FD | 1 |
| Pagaltsos, AP | 1 |
| Eddleston, AL | 1 |
| Anthony, CW | 1 |
| Pritzker, K | 1 |
| Siedek, M | 1 |
| Prange, CH | 1 |
| Rommelsheim, K | 1 |
| Fillmann, B | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
7 reviews available for azathioprine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review.
Topics: Antiviral Agents; Azathioprine; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; H | 2013 |
Liver transplantation: immunosuppression and oncology.
Topics: Antilymphocyte Serum; Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Humans; Immun | 2014 |
Management of autoimmune liver disease.
Topics: Autoantibodies; Azathioprine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellul | 2009 |
Autoimmune hepatitis.
Topics: Algorithms; Azathioprine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Hepatitis, Au | 2011 |
Malignancy after transplantation.
Topics: Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Cyclosporine; Hepatitis, Viral, Hum | 2005 |
Clinical liver transplantation.
Topics: Adenoma, Bile Duct; Adult; Angiography; Aortography; Azathioprine; Bacterial Infections; Biliary Tra | 1969 |
Experience in liver transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Alkalosis; Animals; Antilymphocyte Serum; Azathioprine; Blood Coa | 1969 |
34 other studies available for azathioprine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Carcinoma, Hepato | 2017 |
Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Benzenesulfonates; Carcinoma, Hepatoce | 2009 |
Management of autoimmune and cholestatic liver disorders.
Topics: Anti-Inflammatory Agents; Azathioprine; Carcinoma, Hepatocellular; Cholagogues and Choleretics; Chol | 2009 |
Hepatocellular carcinoma occurring in a young Crohn's disease patient.
Topics: Adolescent; Adult; Age of Onset; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Cr | 2009 |
Hepatocellular carcinoma occurring in a Crohn's disease patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liv | 2010 |
Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease.
Topics: Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liver Neop | 2011 |
Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Buthionine Sulfoximine; Carcinoma | 2011 |
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1.
Topics: Aged; Alanine Transaminase; Azathioprine; Biomarkers; Carcinoma, Hepatocellular; Cholagogues and Cho | 2012 |
Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Gastr | 2006 |
Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents; Azathioprine; Carcinoma, He | 2006 |
Development of hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adult; Azathioprine; Biopsy; Carcinoma, Hepatocellular; Crohn Disease; Diagnosis, Differential; Fata | 2007 |
Hepatic transplantation.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Graft Rejection; Humans; Immunosuppression Th | 1980 |
Primary liver cell cancer occurring in association with Crohn's disease treated with prednisolone and azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Humans; Liver Neoplasms; Pred | 1983 |
Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarc | 1995 |
[Orthotopic liver transplantation (first clinical experience)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Carcinoma, Hepatocellular; Child; Cyclospo | 1993 |
Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Humans; Immunosuppressive Agents; Kidney Transplantat | 1999 |
Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Glycogen; Humans; Immunosuppr | 2000 |
Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Colitis, Ulcerative; Hepatic Veno-Occlusive Disease; | 2001 |
Viral hepatitis and cirrhosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Azathioprine; Carcinoma, Hepatocellular; Chronic Disease; Di | 1975 |
Decreased rate of growth of hepatocellular carcinoma recurrence after liver transplantation in patients maintained on cyclosporine immunosuppression.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Humans; Liver Neoplasms; Liver Transplantatio | 1988 |
De novo hepatocellular carcinoma without chronic liver disease but with 17 years of azathioprine immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Humans; Kidney Transplantation; Liver Neoplasms; Mal | 1987 |
Serum -fetoprotein in hepatoma patients after liver transplantation.
Topics: Adolescent; Adult; Alanine Transaminase; Alpha-Globulins; Aspartate Aminotransferases; Autopsy; Azat | 1971 |
Effect of orthotopic liver transplantation on serum-autoantibodies.
Topics: Antibodies, Antinuclear; Aspartate Aminotransferases; Autoantibodies; Azathioprine; Bilirubin; Carci | 1971 |
Clinical and pathologic observations after orthotopic transplantation of the human liver.
Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc | 1969 |
[Report of experience with homologous liver transplantation].
Topics: Adult; Alkaline Phosphatase; Antibodies, Anti-Idiotypic; Azathioprine; Bilirubin; Blood Proteins; Bo | 1969 |
A case of homologous liver transplantation.
Topics: Adult; Aldosterone; Ampicillin; Azathioprine; Cadaver; Carcinoma, Hepatocellular; Heparin; Humans; L | 1969 |
Observations on prolonged immune suppression for human liver homografts.
Topics: Antilymphocyte Serum; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Fluorescent Anti | 1971 |
Orthotopic liver transplantation in man.
Topics: Adrenal Gland Diseases; Adult; Anticoagulants; Antilymphocyte Serum; Azathioprine; Blood Coagulation | 1969 |
Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinoma, Hepatocellular; Immunosuppre | 1972 |
Total haemolytic complement after liver transplantation and in liver disease.
Topics: Acute Disease; Adult; Aspartate Aminotransferases; Azathioprine; Bilirubin; Carcinoma, Hepatocellula | 1972 |
Disseminated toxoplasmosis in a liver transplant patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Female; Humans; Immunosuppression Therapy; Liver Neo | 1972 |
Neoplasia in renal transplant recipients.
Topics: Adolescent; Azathioprine; Carcinoma, Hepatocellular; Hepatitis; Humans; Immunosuppressive Agents; Ki | 1972 |
[Prolonged ischemic tolerance time of the human liver with successful grafting (author's transl)].
Topics: Adolescent; Antilymphocyte Serum; Azathioprine; Blood Pressure; Carcinoma, Hepatocellular; Drug Ther | 1974 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |