azathioprine has been researched along with Carcinoma, Basal Cell in 22 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone." | 7.75 | Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( Guenova, E; Hoetzenecker, W; Lichte, V; Moehrle, M; Roecken, M; Schaller, M; Woelbing, F, 2009) |
| " Warts (30%) had the larger incidence and were associated with azathioprine (P = 0." | 3.91 | Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients. ( Codarin, FR; Festa Neto, C; Oliveira, WRP; Silva, LLC; Souza, AAV; Tirico, MCCP, 2019) |
| " A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone." | 3.75 | Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. ( Guenova, E; Hoetzenecker, W; Lichte, V; Moehrle, M; Roecken, M; Schaller, M; Woelbing, F, 2009) |
| "A prospective study in the United Kingdom of 1,634 patients without transplants treated with immunosuppressive drugs (68 percent with azathioprine, 28 percent with cyclophosphamide) found an excess of non-Hodgkin's lymphoma and squamous cell skin cancer, suggesting that the excesses (although larger) of the same malignancies found among transplant recipients are not due solely to the foreign antigens of the graft." | 3.67 | Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment. ( Kinlen, LJ, 1985) |
| "However, the risk of acquiring skin cancer increases with the length of immunosuppressive therapy." | 2.67 | No difference in skin cancer incidence with or without cyclosporine--a 5-year perspective. ( Blohmé, I; Larkö, O, 1992) |
| "Three cases of basal cell carcinoma in Crohn's disease patients treated with azathioprine are described." | 2.52 | Crohn's Disease treated with azathioprine and basal cell carcinoma : three cases and literature review. ( Borgies, P; Dubois, A; El Nawar, A; Gallez, JF; Moreels, T; Nakad, A; Patris, A; Rahier, JF; Tennstedt, D; Vandenbulcke, H, 2015) |
| "Incident cases of non-melanoma skin cancers and non-Hodgkin lymphoma diagnosed after prescription of thiopurine and/or anti-tumor necrosis factor-α were identified between April 2008 and January 2018." | 1.56 | Lack of Increased Risk of Lymphoma by Thiopurines or Biologics in Japanese Patients with Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis. ( Hibi, T; Kobayashi, T; Uda, A; Udagawa, E, 2020) |
| "The risk of skin cancer is highly increased in kidney-transplant recipients (KTR), but the risk of subsequent skin cancers is less well studied." | 1.36 | Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. ( Bavinck, JN; Claas, FH; de Fijter, JW; Edelbroek, JR; Haasnoot, GW; Willemze, R; Wisgerhof, HC, 2010) |
| "Squamous cell carcinoma was the most common malignant skin lesion and 84% of all lesions occurred in sun-exposed areas." | 1.33 | Skin cancer in renal allograft recipients--experience in different ethnic groups residing in the same geographical region. ( Gralla, J; Moosa, MR, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, HG | 1 |
| Kuo, KY | 1 |
| Xiao, K | 1 |
| Batra, P | 1 |
| Li, S | 1 |
| Tang, JY | 1 |
| Sarin, KY | 1 |
| Oliveira, WRP | 1 |
| Tirico, MCCP | 1 |
| Souza, AAV | 1 |
| Codarin, FR | 1 |
| Silva, LLC | 1 |
| Festa Neto, C | 1 |
| Vandenbulcke, H | 1 |
| Borgies, P | 1 |
| Dubois, A | 1 |
| Patris, A | 1 |
| Gallez, JF | 1 |
| El Nawar, A | 1 |
| Rahier, JF | 1 |
| Moreels, T | 1 |
| Tennstedt, D | 1 |
| Nakad, A | 1 |
| Jiyad, Z | 1 |
| Olsen, CM | 1 |
| Burke, MT | 1 |
| Isbel, NM | 1 |
| Green, AC | 1 |
| Harwood, CA | 1 |
| Attard, NR | 1 |
| O'Donovan, P | 1 |
| Chambers, P | 1 |
| Perrett, CM | 1 |
| Proby, CM | 1 |
| McGregor, JM | 1 |
| Karran, P | 1 |
| Wisgerhof, HC | 2 |
| Hameetman, L | 1 |
| Tensen, CP | 1 |
| Morreau, H | 1 |
| de Fijter, JW | 2 |
| Bouwes Bavinck, JN | 1 |
| Willemze, R | 2 |
| de Gruijl, FR | 1 |
| Guenova, E | 1 |
| Lichte, V | 1 |
| Hoetzenecker, W | 1 |
| Woelbing, F | 1 |
| Moehrle, M | 1 |
| Roecken, M | 1 |
| Schaller, M | 1 |
| Edelbroek, JR | 1 |
| Haasnoot, GW | 1 |
| Claas, FH | 1 |
| Bavinck, JN | 1 |
| Williams, JV | 1 |
| Revington, PJ | 1 |
| Moosa, MR | 1 |
| Gralla, J | 1 |
| Bergfelt, L | 1 |
| Veness, MJ | 1 |
| Symington, GR | 1 |
| Mackay, IR | 1 |
| Lambert, RP | 1 |
| Blohmé, I | 1 |
| Larkö, O | 1 |
| Xerri, L | 1 |
| Payan, MJ | 1 |
| Choux, R | 1 |
| Gros, N | 1 |
| Hassoun, J | 1 |
| Chamlian, A | 1 |
| Blin, D | 1 |
| Monties, JR | 1 |
| Kinlen, LJ | 1 |
| Walder, BK | 1 |
| Robertson, MR | 1 |
| Jeremy, D | 1 |
| Koranda, FC | 1 |
| Dehmel, EM | 1 |
| Kahn, G | 1 |
| Penn, I | 2 |
| Halgrimson, CG | 1 |
| Booth, A | 1 |
| Groth, C | 1 |
| Putnam, CW | 1 |
| Corman, J | 1 |
| Starzl, TE | 1 |
| Marshall, V | 1 |
| Marshall, VC | 1 |
| Kobayashi, T | 1 |
| Uda, A | 1 |
| Udagawa, E | 1 |
| Hibi, T | 1 |
2 reviews available for azathioprine and Carcinoma, Basal Cell
| Article | Year |
|---|---|
Crohn's Disease treated with azathioprine and basal cell carcinoma : three cases and literature review.
Topics: Adult; Azathioprine; Carcinoma, Basal Cell; Crohn Disease; Female; Humans; Immunosuppressive Agents; | 2015 |
Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Graft Rejection; Humans; Immunosuppre | 2016 |
1 trial available for azathioprine and Carcinoma, Basal Cell
| Article | Year |
|---|---|
No difference in skin cancer incidence with or without cyclosporine--a 5-year perspective.
Topics: Azathioprine; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclosporine; Foll | 1992 |
19 other studies available for azathioprine and Carcinoma, Basal Cell
| Article | Year |
|---|---|
Azathioprine and risk of multiple keratinocyte cancers.
Topics: Aged; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cohort Studies; Female; Humans; | 2018 |
Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Brazil; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chil | 2019 |
PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Carcinoma, Basal Cell; Female; Graft Rejection; Humans | 2008 |
Azathioprine-induced microsatellite instability is not observed in skin carcinomas of organ transplant recipients.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; DNA, Neoplasm; Graft Rejection; Human | 2009 |
Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine.
Topics: Aged; Antineoplastic Agents, Alkylating; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Ce | 2009 |
Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors.
Topics: Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Immunosuppressive Age | 2010 |
Facial basal cell carcinoma in a young patient with Crohn disease.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Carcinoma, Basal Cell; Crohn Disease; Facial Neoplasm | 2010 |
Skin cancer in renal allograft recipients--experience in different ethnic groups residing in the same geographical region.
Topics: Adult; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclosporine; Female; Humans; | 2005 |
Langerhans cells, immunomodulation and skin lesions. A quantitative, morphological and clinical study.
Topics: Adenosine Triphosphatases; Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Animals; Antigens | 1993 |
Cardiac transplant-related cutaneous malignancies in an Australian recipient: immunosuppression, friend or foe?
Topics: Adult; Australia; Azathioprine; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cy | 1998 |
Cancer and teratogenesis: infrequent occurrence after medical use of immunosuppressive drugs.
Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous C | 1977 |
An exceptional 18-year follow-up after cardiac transplantation. How can malignancies occur during immunosuppressive therapy?
Topics: Adenocarcinoma, Papillary; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Follow-Up | 1989 |
Incidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squa | 1985 |
Skin cancer and immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Immunosuppress | 1971 |
Cutaneous complications in immunosuppressed renal homograft recipients.
Topics: Acne Vulgaris; Adolescent; Adult; Alopecia; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous | 1974 |
Eight- to ten-year follow-up in early cases of renal homotransplantation.
Topics: Adolescent; Adult; Azathioprine; Blood Group Incompatibility; Carcinoma, Basal Cell; Carcinoma, Baso | 1973 |
Premalignant and malignant skin tumours in immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Azathioprine; Cadaver; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyc | 1974 |
Skin tumours in immunosuppressed patients.
Topics: Adolescent; Adult; Allopurinol; Antineoplastic Agents; Azathioprine; Carcinoma, Basal Cell; Carcinom | 1973 |
Lack of Increased Risk of Lymphoma by Thiopurines or Biologics in Japanese Patients with Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis.
Topics: Adalimumab; Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Colitis, Ulcerative; Crohn | 2020 |