azathioprine has been researched along with Cancer of Liver in 83 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease." | 7.80 | Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 7.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| " Patients received immunosuppressor treatment with azathioprine (AZA) and developed hepatic hemangiomas without detectable hepatic pathology previous to the treatment with AZA." | 7.68 | [Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine]. ( Calvo Catalá, FJ; González-Cruz, I; Hortelano Martínez, E; Liñana Santafé, JJ; Martínez San Juan, V, 1992) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 5.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids." | 5.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| " The variety of acute hepatitis include hepatitis A, hepatitis B, cytomegalovirus hepatitis, herpes simplex hepatitis and azathioprine hepatitis." | 4.75 | Liver disease in renal transplant recipients. ( Anuras, S; Sopko, J, 1978) |
| "We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine." | 3.83 | Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. ( Arrenberg, P; Brinkert, F; Grabhorn, E; Krech, T; Lohse, A; Schramm, C, 2016) |
| " To our knowledge this is the first reported case of LYG related to azathioprine therapy in Crohn disease." | 3.80 | Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease. ( Belletrutti, PJ; Connors, W; Griffiths, C; Patel, J, 2014) |
| "Reported herein is a case of hepatocellular carcinoma (HCC) occurring in a 25-year-old Japanese man who was diagnosed with Crohn's disease (CD) at 14 years of age; treatment included predonisolone, azathioprine, and infliximab." | 3.75 | Hepatocellular carcinoma occurring in a young Crohn's disease patient. ( Enaka, M; Kawachi, K; Kunisaki, R; Morimoto, M; Murakami, A; Nagano, Y; Nozawa, A; Sasaki, T; Tanabe, M; Tanaka, Y; Ueda, M, 2009) |
| "A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease." | 3.70 | Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy. ( Cattan, S; Chazouilleres, O; Gendre, JP; Schmitz, J; Wendum, D, 2000) |
| "Azathioprine and rheumatoid arthritis are known to be associated with an increased risk of the development of non-Hodgkin's lymphoma; however, the manifestation of fulminant hepatic failure is extremely uncommon in patients with non-Hodgkin's lymphoma." | 3.69 | Azathioprine-induced lymphoma manifesting as fulminant hepatic failure. ( Aguilar, HI; Burgart, LJ; Geller, A; Rakela, J, 1997) |
| " Patients received immunosuppressor treatment with azathioprine (AZA) and developed hepatic hemangiomas without detectable hepatic pathology previous to the treatment with AZA." | 3.68 | [Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine]. ( Calvo Catalá, FJ; González-Cruz, I; Hortelano Martínez, E; Liñana Santafé, JJ; Martínez San Juan, V, 1992) |
| "Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) was recognized as a new disease entity; however, IgG4-associated de novo AIH after the liver transplantation had not been reported yet." | 2.49 | Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review. ( Jia, JD; Rakhda, MI; Wang, TI; Zhao, XY, 2013) |
| " Adequately dosed steroids are the mainstay of remission induction treatment, while remission maintenance is best achieved by azathioprine." | 2.47 | Autoimmune hepatitis. ( Lohse, AW; Mieli-Vergani, G, 2011) |
| "Left breast cancer was diagnosed 9 years after the renal transplantation, then colon cancers and meningeal epidermal meningioma were diagnosed, 10 years and 12 years post-transplant, respectively." | 2.42 | Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case. ( Asahara, T; Dohi, K; Fukuda, Y; Hayamizu, K; Ikeda, S; Kataoka, T; Kitayama, T; Marubayashi, S; Ohdan, H; Okajima, M; Okimoto, T; Sugino, K; Tashiro, H, 2004) |
| "Ascites, variceal bleeding, and hepatocellular carcinoma were found in 1." | 1.46 | Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. ( Choi, HY; Jang, ES; Jeong, SH; Ki, M; Kim, BH; Kim, KA, 2017) |
| "Hepatoblastoma is a primary liver cancer that affects children, due to the sensitivity of this tumor to insulin-like growth factor 1 (IGF-1)." | 1.39 | Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. ( Fernández-Moreno, MD; Gisbert, JP; González-Rodríguez, Á; Guijarro, LG; Hernández-Breijo, B; Lobo, MV; Monserrat, J; Román, ID; Valverde, ÁM, 2013) |
| "The development of hepatocellular carcinoma (HCC) is attributed to several factors, including chronic viral infection, alcohol consumption, exposure to aflatoxin B1 and metabolic disorders." | 1.37 | Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease. ( Cui, DJ; Ouyang, Q; Zheng, SM, 2011) |
| "Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 °C incubator with 5% CO₂." | 1.37 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma. ( Cuevas, EP; Díaz-Laviada, I; Fernández-Moreno, MD; Gisbert, JP; Guijarro, LG; Hernández-Breijo, B; Monserrat, J; Ramírez-Rubio, S; Román, ID; Vara, D, 2011) |
| "We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients." | 1.36 | Hepatocellular carcinoma occurring in a Crohn's disease patient. ( Andoh, A; Fujiyama, Y; Hotta, M; Ishida, M; Kojima, F; Kurumi, Y; Naka, S; Nakahara, T; Okabe, H; Saito, Y; Shiomi, H; Takikita-Suzuki, M; Tani, T; Tsujikawa, T, 2010) |
| "Dermatomyositis is a known paraneoplastic syndrome that can complicate the course of a variety of different cancers, however, the association with HCC is extremely rare." | 1.35 | Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib. ( Apostolidis, L; Horstmann, S; Jäger, D; Kahlert, C; Lordick, F; Siegmund, A; Thom, R, 2009) |
| "All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids." | 1.33 | Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab. ( Chen, SC; Cho, WK; Cummings, OW; Filomena, CA; Hartley, MP, 2006) |
| "Although the prognosis of type 1 autoimmune hepatitis is generally good with immunosuppressive treatment, the disease progresses in some patients despite the treatment." | 1.33 | Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis. ( Ikeda, H; Iwasaki, Y; Kobashi, H; Makino, Y; Miyake, Y; Okamaoto, R; Sakaguchi, K; Shiratori, Y; Takaguchi, K; Terada, R, 2006) |
| "The occurrence of hepatocellular carcinoma (HCC) in renal transplant recipients has typically been associated with hepatitis B or C infection." | 1.30 | Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series. ( Adams, MB; Franco, J; Komorowski, RA; Saeian, K, 1999) |
| "The thrombocytopenia was diagnosed as idiopathic thrombocytopenic purpura." | 1.30 | [Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura]. ( Kariya, K; Kawamura, S; Munakata, A; Nakahata, R; Takami, H; Tamai, Y; Tsushima, K; Yoshimura, T, 1999) |
| " There was no increase in concurrent immunosuppressives dosage after the conversion." | 1.29 | Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation. ( Kaplan, MM; Pedrosa, MC; Rohrer, RM, 1995) |
| "Azathioprine was administered to 25 patients with severe, progressive polyarthritis in a mean dose of 1." | 1.26 | Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients. ( Pinals, RS, 1976) |
| "Later, primary hepatocellular carcinoma assumes increasing importance." | 1.25 | Viral hepatitis and cirrhosis. ( Sherlock, S, 1975) |
| "Two patients developed reticulum cell sarcomata after they had been treated with azathioprine and prednisone in the course of cadaveric renal transplantation." | 1.25 | Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy. ( Doak, PB; Montgomerie, JZ; North, JD; Smith, F, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (50.60) | 18.7374 |
| 1990's | 10 (12.05) | 18.2507 |
| 2000's | 13 (15.66) | 29.6817 |
| 2010's | 18 (21.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, BH | 1 |
| Choi, HY | 1 |
| Ki, M | 1 |
| Kim, KA | 1 |
| Jang, ES | 1 |
| Jeong, SH | 1 |
| Mavilia, M | 1 |
| McAuliffe, A | 1 |
| Hafeez, S | 1 |
| Vaziri, H | 1 |
| Zhao, XY | 1 |
| Rakhda, MI | 1 |
| Wang, TI | 1 |
| Jia, JD | 1 |
| Hernández-Breijo, B | 2 |
| Monserrat, J | 2 |
| Román, ID | 2 |
| González-Rodríguez, Á | 1 |
| Fernández-Moreno, MD | 2 |
| Lobo, MV | 1 |
| Valverde, ÁM | 1 |
| Gisbert, JP | 2 |
| Guijarro, LG | 2 |
| Rodríguez-Perálvarez, M | 1 |
| De la Mata, M | 1 |
| Burroughs, AK | 1 |
| Connors, W | 1 |
| Griffiths, C | 1 |
| Patel, J | 1 |
| Belletrutti, PJ | 1 |
| Brinkert, F | 1 |
| Arrenberg, P | 1 |
| Krech, T | 1 |
| Grabhorn, E | 1 |
| Lohse, A | 1 |
| Schramm, C | 1 |
| van de Meeberg, MM | 1 |
| Derikx, LA | 1 |
| Sinnige, HA | 1 |
| Nooijen, P | 1 |
| Schipper, DL | 1 |
| Nissen, LH | 1 |
| Moran, G | 1 |
| Dillon, J | 1 |
| Green, J | 1 |
| Apostolidis, L | 1 |
| Kahlert, C | 1 |
| Siegmund, A | 1 |
| Thom, R | 1 |
| Horstmann, S | 1 |
| Jäger, D | 1 |
| Lordick, F | 1 |
| Maggs, J | 1 |
| Cullen, S | 1 |
| Krok, KL | 1 |
| Munoz, SJ | 1 |
| Murakami, A | 1 |
| Tanaka, Y | 1 |
| Ueda, M | 1 |
| Nagano, Y | 1 |
| Kunisaki, R | 1 |
| Morimoto, M | 1 |
| Enaka, M | 1 |
| Tanabe, M | 1 |
| Kawachi, K | 1 |
| Sasaki, T | 1 |
| Nozawa, A | 1 |
| Ochenrider, MG | 1 |
| Patterson, DJ | 1 |
| Aboulafia, DM | 1 |
| Ishida, M | 1 |
| Naka, S | 1 |
| Shiomi, H | 1 |
| Tsujikawa, T | 1 |
| Andoh, A | 1 |
| Nakahara, T | 1 |
| Saito, Y | 1 |
| Kurumi, Y | 1 |
| Takikita-Suzuki, M | 1 |
| Kojima, F | 1 |
| Hotta, M | 1 |
| Tani, T | 1 |
| Fujiyama, Y | 1 |
| Okabe, H | 1 |
| Thai, A | 1 |
| Prindiville, T | 1 |
| Lohse, AW | 1 |
| Mieli-Vergani, G | 1 |
| Zheng, SM | 1 |
| Cui, DJ | 1 |
| Ouyang, Q | 1 |
| Ramírez-Rubio, S | 1 |
| Cuevas, EP | 1 |
| Vara, D | 1 |
| Díaz-Laviada, I | 1 |
| Hino-Arinaga, T | 1 |
| Ide, T | 1 |
| Kuromatsu, R | 1 |
| Miyajima, I | 1 |
| Ogata, K | 1 |
| Kuwahara, R | 1 |
| Hisamochi, A | 1 |
| Torimura, T | 1 |
| Sata, M | 1 |
| Rashidi, A | 1 |
| Lee, ME | 1 |
| Fisher, SI | 1 |
| de Vries, HS | 1 |
| de Heij, T | 1 |
| Roelofs, HM | 1 |
| te Morsche, RH | 1 |
| Peters, WH | 1 |
| de Jong, DJ | 1 |
| Bašić Kinda, S | 1 |
| Duraković, N | 1 |
| Dotlić, S | 1 |
| Serventi Seiwerth, R | 1 |
| Davidović Mrsić, S | 1 |
| Dubravčić, K | 1 |
| Aurer, I | 1 |
| Navarro, JT | 1 |
| Ribera, JM | 1 |
| Mate, JL | 1 |
| Granada, I | 1 |
| Juncà, J | 1 |
| Batlle, M | 1 |
| Millá, F | 1 |
| Feliu, E | 1 |
| Kitayama, T | 1 |
| Marubayashi, S | 1 |
| Hayamizu, K | 1 |
| Tashiro, H | 1 |
| Ohdan, H | 1 |
| Ikeda, S | 1 |
| Okimoto, T | 1 |
| Okajima, M | 1 |
| Kataoka, T | 1 |
| Sugino, K | 1 |
| Asahara, T | 1 |
| Fukuda, Y | 1 |
| Dohi, K | 1 |
| Chen, SC | 1 |
| Cummings, OW | 1 |
| Hartley, MP | 1 |
| Filomena, CA | 1 |
| Cho, WK | 1 |
| Miyake, Y | 1 |
| Iwasaki, Y | 1 |
| Terada, R | 1 |
| Okamaoto, R | 1 |
| Ikeda, H | 1 |
| Makino, Y | 1 |
| Kobashi, H | 1 |
| Takaguchi, K | 1 |
| Sakaguchi, K | 1 |
| Shiratori, Y | 1 |
| Muirhead, R | 1 |
| Ritchie, DM | 1 |
| Samarasena, J | 1 |
| Borgaonkar, M | 1 |
| Sakata, T | 1 |
| Watanabe, A | 1 |
| Takei, N | 1 |
| Shiota, T | 1 |
| Nakatsukasa, H | 1 |
| Fujiwara, M | 1 |
| Kobayashi, M | 1 |
| Nagashima, H | 1 |
| Calne, R | 1 |
| Lee, FL | 1 |
| Murray, SM | 1 |
| Prior, J | 1 |
| Shreeve, DR | 1 |
| Bismuth, H | 1 |
| Pedrosa, MC | 1 |
| Rohrer, RM | 1 |
| Kaplan, MM | 1 |
| Lipkowitz, GS | 1 |
| Madden, RL | 1 |
| Cherqui, D | 1 |
| Duvoux, C | 1 |
| Charlotte, F | 1 |
| Humeres, R | 1 |
| Lauzet, JY | 1 |
| Métreau, JM | 1 |
| Salvat, A | 1 |
| Rotman, N | 1 |
| Julien, M | 1 |
| Fagniez, PL | 1 |
| Konstantinov, BA | 1 |
| Eramishantsev, AK | 1 |
| Goté, SV | 1 |
| Tsirulńikova, OM | 1 |
| Skipenko, OG | 1 |
| Lebezev, VM | 1 |
| Shertsinger, AG | 1 |
| Lokshin, LS | 1 |
| Volgger, B | 1 |
| Marth, C | 1 |
| Zeimet, A | 1 |
| Müller-Holzner, E | 1 |
| Ruth, N | 1 |
| Dapunt, O | 1 |
| Aguilar, HI | 1 |
| Burgart, LJ | 1 |
| Geller, A | 1 |
| Rakela, J | 1 |
| Saeian, K | 1 |
| Franco, J | 1 |
| Komorowski, RA | 1 |
| Adams, MB | 1 |
| Yoshimura, T | 1 |
| Tamai, Y | 1 |
| Takami, H | 1 |
| Kariya, K | 1 |
| Nakahata, R | 1 |
| Tsushima, K | 1 |
| Munakata, A | 1 |
| Kawamura, S | 1 |
| Cattan, S | 1 |
| Wendum, D | 1 |
| Chazouilleres, O | 1 |
| Schmitz, J | 1 |
| Gendre, JP | 1 |
| Russmann, S | 1 |
| Zimmermann, A | 1 |
| Krähenbühl, S | 1 |
| Kern, B | 1 |
| Reichen, J | 1 |
| Sherlock, S | 1 |
| Sopko, J | 1 |
| Anuras, S | 1 |
| Pinals, RS | 1 |
| Liñana Santafé, JJ | 1 |
| Calvo Catalá, FJ | 1 |
| Hortelano Martínez, E | 1 |
| González-Cruz, I | 1 |
| Martínez San Juan, V | 1 |
| O'Grady, JG | 1 |
| Johnson, PJ | 1 |
| Zaman, S | 1 |
| Calne, RY | 2 |
| Williams, R | 5 |
| Gruber, S | 1 |
| Dehner, LP | 1 |
| Simmons, RL | 1 |
| Alpert, E | 1 |
| Starzl, TE | 6 |
| Schur, PH | 1 |
| Isselbacher, KJ | 1 |
| Smith, MG | 3 |
| Doniach, D | 1 |
| Pierce, JC | 1 |
| Madge, GE | 1 |
| Lee, HM | 1 |
| Hume, DM | 1 |
| Groth, CG | 3 |
| Brettschneider, L | 6 |
| Moon, JB | 2 |
| Fulginiti, VA | 2 |
| Cotton, EK | 1 |
| Porter, KA | 3 |
| Casey, TP | 1 |
| Penn, I | 5 |
| Bell, P | 2 |
| Putnam, CW | 3 |
| McGuire, RL | 1 |
| Gütgemann, A | 4 |
| Schriefers, KH | 2 |
| Esser, G | 2 |
| Lee, TS | 1 |
| Paquet, KJ | 2 |
| Käufer, C | 3 |
| Lie, TS | 4 |
| Fortner, JG | 2 |
| Shiu, MH | 2 |
| Balner, H | 1 |
| Wilson, CB | 1 |
| Sichuk, G | 1 |
| Kawano, N | 1 |
| Holmes, JT | 1 |
| Beattie, EJ | 1 |
| Blanchard, H | 2 |
| Kashiwagi, N | 1 |
| Starzi, TE | 1 |
| Giles, G | 1 |
| Picache, R | 1 |
| Prejean, JD | 1 |
| Griswold, DP | 1 |
| Weisburger, JH | 2 |
| Birtch, AG | 1 |
| Moore, FD | 1 |
| Pagaltsos, AP | 1 |
| Eddleston, AL | 1 |
| Anthony, CW | 1 |
| Pritzker, K | 1 |
| Kinne, DW | 1 |
| Howland, WS | 1 |
| Kim, DK | 1 |
| Castro, EB | 1 |
| Yeh, SD | 1 |
| Benua, RS | 1 |
| Krumins, S | 1 |
| Siedek, M | 1 |
| Prange, CH | 1 |
| Rommelsheim, K | 1 |
| Fillmann, B | 1 |
| Birkeland, SA | 1 |
| Kemp, E | 1 |
| Ulrich, J | 1 |
| Wüthrich, R | 1 |
| Klatskin, G | 1 |
| Kantor, FS | 1 |
| von Bally, K | 1 |
| Ebata, H | 1 |
| Nakano, H | 1 |
| Guisan, Y | 1 |
| Enderlin, F | 1 |
| Harder, F | 1 |
| Brunner, F | 1 |
| Thiel, G | 2 |
| Bernhardt, JP | 1 |
| Schädeli, J | 1 |
| Mihatsch, M | 1 |
| Martin, AJ | 1 |
| Doak, PB | 1 |
| Montgomerie, JZ | 1 |
| North, JD | 1 |
| Smith, F | 1 |
| Kommerell, B | 1 |
| Breuer, J | 1 |
| Breuer, H | 1 |
| Eiseman, B | 1 |
| Hammond, W | 1 |
| Frankel, HH | 1 |
| Yamamoto, RS | 1 |
| Weisburger, EK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety and Efficacy of Basiliximab, Delayed Dose Tacrolimus Plus ECMPA, Versus Standard Dose Tacrolimus, ECMPA Plus Corticosteroids in Patients Undergoing Liver Transplant[NCT02123108] | Phase 4 | 59 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02123108)
Timeframe: 12 months post liver transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 3 |
| Tacrolimus Group | 4 |
(NCT02123108)
Timeframe: 12 months post liver transplantation
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 0 |
| Tacrolimus Group | 0 |
(NCT02123108)
Timeframe: 12 months post transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 2 |
| Tacrolimus Group | 5 |
Number of participants who experienced dialysis independence or improvement based upon kidney function labs as a measure of renal recovery/ function following OLT in patients after undergoing orthotopic liver transplant (NCT02123108)
Timeframe: 12 months post-transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 28 |
| Tacrolimus Group | 26 |
Participants at risk minus incidence of death within the first year post-transplant (NCT02123108)
Timeframe: 12 months post liver transplant
| Intervention | Participants (Count of Participants) |
|---|---|
| Basiliximab | 28 |
| Tacrolimus Group | 26 |
13 reviews available for azathioprine and Cancer of Liver
| Article | Year |
|---|---|
Immunoglobulin G4-associated de novo autoimmune hepatitis after liver transplantation for chronic hepatitis B- and C-related cirrhosis and hepatocellular carcinoma: a case report with literature review.
Topics: Antiviral Agents; Azathioprine; Carcinoma, Hepatocellular; Coinfection; Drug Therapy, Combination; H | 2013 |
Liver transplantation: immunosuppression and oncology.
Topics: Antilymphocyte Serum; Azathioprine; Calcineurin Inhibitors; Carcinoma, Hepatocellular; Humans; Immun | 2014 |
Management of autoimmune liver disease.
Topics: Autoantibodies; Azathioprine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellul | 2009 |
Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review.
Topics: Adalimumab; Adolescent; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Ag | 2010 |
Hepatosplenic T-cell lymphoma and inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Humans; Immunophenotyping; Immunosup | 2010 |
Autoimmune hepatitis.
Topics: Algorithms; Azathioprine; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Hepatitis, Au | 2011 |
Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case.
Topics: Azathioprine; Breast Neoplasms; Carcinoma, Ductal, Breast; Colonic Neoplasms; Colonic Polyps; Drug T | 2004 |
[Value of a powerful initial immunosuppression after liver transplantation. Prospective study of 60 cases].
Topics: Adult; Aged; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; Hepatit | 1994 |
Liver disease in renal transplant recipients.
Topics: Animals; Azathioprine; Budd-Chiari Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Ch | 1978 |
Clinical liver transplantation.
Topics: Adenoma, Bile Duct; Adult; Angiography; Aortography; Azathioprine; Bacterial Infections; Biliary Tra | 1969 |
Experience in liver transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Alkalosis; Animals; Antilymphocyte Serum; Azathioprine; Blood Coa | 1969 |
[Liver transplantation (current status and perspectives)].
Topics: Animals; Antilymphocyte Serum; Azathioprine; Bile Ducts; Blood Group Antigens; Dogs; Graft Rejection | 1973 |
[Liver transplantation in humans].
Topics: Antilymphocyte Serum; Azathioprine; Biliary Tract Diseases; Graft Rejection; Hepatectomy; Histocompa | 1970 |
1 trial available for azathioprine and Cancer of Liver
| Article | Year |
|---|---|
Comparison of FK 506- and cyclosporine-based immunosuppression: FK 506 therapy significantly reduces the incidence of acute, steroid-resistant, refractory, and chronic rejection whilst possessing a comparable safety profile. European FK 506 Multicenter Li
Topics: Antilymphocyte Serum; Azathioprine; Cyclosporine; Drug Resistance; Drug Therapy, Combination; Female | 1995 |
69 other studies available for azathioprine and Cancer of Liver
| Article | Year |
|---|---|
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Azathioprine; Carcinoma, Hepato | 2017 |
Hepatosplenic T cell lymphoma: a unifying entity in a patient with hemolytic anemia, massive splenomegaly, and liver dysfunction.
Topics: Adult; Anemia, Hemolytic; Azathioprine; Biopsy; Chronic Disease; Colitis, Ulcerative; Fatal Outcome; | 2018 |
Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Cell Line, Tumor; Drug Therapy, Combinatio | 2013 |
Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.
Topics: Adult; Azathioprine; Brain Neoplasms; Crohn Disease; Female; Humans; Immunocompromised Host; Immunos | 2014 |
Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis.
Topics: Adolescent; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Liver Neo | 2016 |
Hepatosplenic T-cell lymphoma in a 47-year-old Crohn's disease patient on thiopurine monotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Biopsy; Crohn Disease; Drug Administra | 2016 |
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree?
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Glucocorticoids; Humans | 2009 |
Remission of paraneoplastic dermatomyositis associated with hepatocellular carcinoma under prednisolone and azathiopin, and concommittant sorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azathioprine; Benzenesulfonates; Carcinoma, Hepatoce | 2009 |
Management of autoimmune and cholestatic liver disorders.
Topics: Anti-Inflammatory Agents; Azathioprine; Carcinoma, Hepatocellular; Cholagogues and Choleretics; Chol | 2009 |
Hepatocellular carcinoma occurring in a young Crohn's disease patient.
Topics: Adolescent; Adult; Age of Onset; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Cr | 2009 |
Hepatocellular carcinoma occurring in a Crohn's disease patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liv | 2010 |
Gut-liver axis plays a role in hepatocarcinogenesis of patients with Crohn's disease.
Topics: Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Humans; Immunosuppressive Agents; Liver Neop | 2011 |
Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azathioprine; Buthionine Sulfoximine; Carcinoma | 2011 |
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1.
Topics: Aged; Alanine Transaminase; Azathioprine; Biomarkers; Carcinoma, Hepatocellular; Cholagogues and Cho | 2012 |
Hepatosplenic αβ T-cell lymphoma associated with azathioprine therapy.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Liver Neoplasms; Lupus Erythematosus, System | 2012 |
Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro.
Topics: Analysis of Variance; Antibodies, Monoclonal; Azathioprine; Cell Survival; Dose-Response Relationshi | 2012 |
Hepatosplenic αβ T-cell lymphoma arising after long-term azathioprine therapy successfully treated with allogeneic bone marrow transplant.
Topics: Azathioprine; Bone Marrow Transplantation; Crohn Disease; Humans; Immunosuppressive Agents; Liver Ne | 2013 |
Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; | 2003 |
Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Gastr | 2006 |
Persistent elevation of serum alanine aminotransferase levels leads to poor survival and hepatocellular carcinoma development in type 1 autoimmune hepatitis.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anti-Inflammatory Agents; Azathioprine; Carcinoma, He | 2006 |
Partial regression of Merkel cell carcinoma in response to withdrawal of azathioprine in an immunosuppression-induced case of metastatic Merkel cell carcinoma.
Topics: Azathioprine; Carcinoma, Merkel Cell; Fatal Outcome; Head and Neck Neoplasms; Humans; Immunocompromi | 2007 |
Development of hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adult; Azathioprine; Biopsy; Carcinoma, Hepatocellular; Crohn Disease; Diagnosis, Differential; Fata | 2007 |
Effect of azathioprine and carbon tetrachloride on induction of hyperplastic liver nodule and hepatocellular carcinoma by diethylnitrosamine and N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Aniline Hydroxylase; Animals; Azathioprine; Carbon Tetrachloride; Diethylnitr | 1983 |
Hepatic transplantation.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Graft Rejection; Humans; Immunosuppression Th | 1980 |
Primary liver cell cancer occurring in association with Crohn's disease treated with prednisolone and azathioprine.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Humans; Liver Neoplasms; Pred | 1983 |
Liver grafting.
Topics: Azathioprine; Cyclosporins; Graft Rejection; Graft Survival; Humans; Liver Diseases; Liver Neoplasms | 1983 |
Alternate-day prednisone in the maintenance immunosuppressive therapy after orthotopic liver transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Cholangiocarc | 1995 |
Transmission of Kaposi's sarcoma by solid organ donation.
Topics: Adult; Azathioprine; Cyclosporine; Disease Transmission, Infectious; Fatal Outcome; Female; Follow-U | 1994 |
[Orthotopic liver transplantation (first clinical experience)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Azathioprine; Carcinoma, Hepatocellular; Child; Cyclospo | 1993 |
Fulminant course of a microinvasive vulvar carcinoma in an immunosuppressed woman.
Topics: Adult; Azathioprine; Carcinogens; Carcinoma in Situ; Carcinoma, Squamous Cell; Condylomata Acuminata | 1997 |
Azathioprine-induced lymphoma manifesting as fulminant hepatic failure.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; F | 1997 |
Hepatocellular carcinoma after renal transplantation in the absence of cirrhosis or viral hepatitis: a case series.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Humans; Immunosuppressive Agents; Kidney Transplantat | 1999 |
[Rapidly progressive irradiated cervical cancer that metastasized to the liver during therapy for idiopathic thrombocytopenic purpura].
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunosuppressiv | 1999 |
Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Crohn Disease; Female; Glycogen; Humans; Immunosuppr | 2000 |
Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.
Topics: Aged; Azathioprine; Carcinoma, Hepatocellular; Colitis, Ulcerative; Hepatic Veno-Occlusive Disease; | 2001 |
Viral hepatitis and cirrhosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Azathioprine; Carcinoma, Hepatocellular; Chronic Disease; Di | 1975 |
Azathioprine in the treatment of chronic polyarthritis: longterm results and adverse effects in 25 patients.
Topics: Adenocarcinoma; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Breast Neoplasms; Carcinoma; Femal | 1976 |
[Hepatic hemangiomas and rheumatoid arthritis in patients treated with azathioprine].
Topics: Arthritis, Rheumatoid; Azathioprine; Hemangioma; Humans; Liver Neoplasms; Male; Middle Aged | 1992 |
Decreased rate of growth of hepatocellular carcinoma recurrence after liver transplantation in patients maintained on cyclosporine immunosuppression.
Topics: Azathioprine; Carcinoma, Hepatocellular; Cyclosporins; Humans; Liver Neoplasms; Liver Transplantatio | 1988 |
De novo hepatocellular carcinoma without chronic liver disease but with 17 years of azathioprine immunosuppression.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Humans; Kidney Transplantation; Liver Neoplasms; Mal | 1987 |
Serum -fetoprotein in hepatoma patients after liver transplantation.
Topics: Adolescent; Adult; Alanine Transaminase; Alpha-Globulins; Aspartate Aminotransferases; Autopsy; Azat | 1971 |
Effect of orthotopic liver transplantation on serum-autoantibodies.
Topics: Antibodies, Antinuclear; Aspartate Aminotransferases; Autoantibodies; Azathioprine; Bilirubin; Carci | 1971 |
Lymphoma, a complication of renal allotransplantation in man.
Topics: Adolescent; Adult; Azathioprine; Dactinomycin; Histocompatibility Testing; Humans; Kidney Transplant | 1972 |
Extended survival in 3 cases of orthotopic homotransplantation of the human liver.
Topics: Acidosis; Azathioprine; Biliary Tract; Cadaver; Child, Preschool; Female; gamma-Globulins; Humans; I | 1968 |
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
Topics: Albuminuria; Anemia, Hemolytic, Autoimmune; Animals; Azathioprine; Coombs Test; Glomerulonephritis; | 1968 |
Clinical and pathologic observations after orthotopic transplantation of the human liver.
Topics: Adolescent; Adult; Alkaline Phosphatase; Azathioprine; Bilirubin; Blood Proteins; Carcinoma, Hepatoc | 1969 |
[Report of experience with homologous liver transplantation].
Topics: Adult; Alkaline Phosphatase; Antibodies, Anti-Idiotypic; Azathioprine; Bilirubin; Blood Proteins; Bo | 1969 |
A case of homologous liver transplantation.
Topics: Adult; Aldosterone; Ampicillin; Azathioprine; Cadaver; Carcinoma, Hepatocellular; Heparin; Humans; L | 1969 |
Observations on prolonged immune suppression for human liver homografts.
Topics: Antilymphocyte Serum; Azathioprine; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Fluorescent Anti | 1971 |
Orthotopic liver transplantation in man.
Topics: Adrenal Gland Diseases; Adult; Anticoagulants; Antilymphocyte Serum; Azathioprine; Blood Coagulation | 1969 |
Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum.
Topics: Adenocarcinoma; Animals; Antilymphocyte Serum; Azathioprine; Carcinoma, Hepatocellular; Immunosuppre | 1972 |
Total haemolytic complement after liver transplantation and in liver disease.
Topics: Acute Disease; Adult; Aspartate Aminotransferases; Azathioprine; Bilirubin; Carcinoma, Hepatocellula | 1972 |
Disseminated toxoplasmosis in a liver transplant patient.
Topics: Adult; Azathioprine; Carcinoma, Hepatocellular; Female; Humans; Immunosuppression Therapy; Liver Neo | 1972 |
Neoplasia in renal transplant recipients.
Topics: Adolescent; Azathioprine; Carcinoma, Hepatocellular; Hepatitis; Humans; Immunosuppressive Agents; Ki | 1972 |
Clinical liver heterotopic (auxiliary) transplantation.
Topics: Adenoma, Bile Duct; Adult; Aged; Antibodies; Antilymphocyte Serum; Azathioprine; Bilirubin; Child, P | 1973 |
[Prolonged ischemic tolerance time of the human liver with successful grafting (author's transl)].
Topics: Adolescent; Antilymphocyte Serum; Azathioprine; Blood Pressure; Carcinoma, Hepatocellular; Drug Ther | 1974 |
Malignant tumours following immunosuppression in renal transplantation.
Topics: Adenocarcinoma; Adult; Azathioprine; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinom | 1973 |
Multiple sclerosis: reticulum cell sarcoma of the nervous system in a patient treated with immunosuppressive drugs.
Topics: Adrenocorticotropic Hormone; Adult; Autopsy; Azathioprine; Biopsy, Needle; Brain Neoplasms; Cortison | 1974 |
Mitochondrial antibody in primary biliary cirrhosis and other diseases.
Topics: Antibodies; Azathioprine; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Ch | 1972 |
Liver transplantation: a clinical and immunological appraisal.
Topics: Adult; Animals; Autoantibodies; Azathioprine; Biliary Fistula; Cell Migration Inhibition; Complement | 1972 |
[Malignant tumors following transplantation. Case reports and review of the literature].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Graft Rejection; Humans; Kidney | 1973 |
Orthotopic homotransplantation of the human liver.
Topics: Adolescent; Adult; Azathioprine; Bile Ducts; Cadaver; Child; Child, Preschool; Hepatic Artery; Human | 1968 |
Reticulum cell sarcoma after renal homotransplantation and azathioprine and prednisone therapy.
Topics: Adult; Azathioprine; Brain Neoplasms; Female; Herpes Simplex; Humans; Kidney Transplantation; Liver | 1968 |
[Possibilities and limitations of modern therapy of hepatic coma. Exchange transfusion, liver perfusion, and liver transplantation].
Topics: Adult; Animals; Azathioprine; Exchange Transfusion, Whole Blood; Female; Hepatic Encephalopathy; Hum | 1969 |
[Clinical chemistry studies of a patient following transplantation of a human liver].
Topics: Adenosine Triphosphate; Adult; Alanine Transaminase; Alkaline Phosphatase; Antilymphocyte Serum; Asp | 1970 |
Liver transplantation.
Topics: Antilymphocyte Serum; Atrophy; Azathioprine; Biliary Tract; Congenital Abnormalities; Histocompatibi | 1970 |
[Liver transplantation in man].
Topics: Acidosis; Adult; Azathioprine; Bile Duct Neoplasms; Brain Death; Brain Diseases; Electroencephalogra | 1970 |
Malignant lymphomas in transplantation patients.
Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Brain Neoplasms; Female; Humans; Immunosuppre | 1969 |
Chronic toxicity of azathioprine and the effect of this immunosuppressant on liver tumor induction by the carcinogen N-hydroxy-N-2-fluorenylacetamide.
Topics: Amides; Animals; Animals, Laboratory; Azathioprine; Body Weight; Carcinogens; Diet; Female; Liver; L | 1970 |