azathioprine has been researched along with Bronchiolitis, Exudative in 25 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Everolimus is a proliferation signal inhibitor with immunosuppressive activity that may reduce the rate of progression of chronic rejection, bronchiolitis obliterans syndrome (BOS), after lung transplantation." | 5.12 | Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial. ( Aris, R; Glanville, AR; Hmissi, A; Loyd, JE; McGiffin, DC; Pirron, U; Roman, A; Snell, GI; Sole, A; Valentine, VG; Vitulo, P, 2006) |
| "Tacrolimus is associated with a lower burden of acute rejection and lymphocytic bronchitis and a trend to a greater freedom from BOS stage 0-p than cyclosporine after lung transplantation." | 5.12 | A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation. ( Aloush, AA; Chakinala, MM; Hachem, RR; Lynch, JP; Meyers, BF; Patterson, GA; Trulock, EP; Yusen, RD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellon, H | 1 |
| Vandermeulen, E | 1 |
| Verleden, SE | 1 |
| Heigl, T | 1 |
| Vriens, H | 1 |
| Lammertyn, E | 1 |
| Verlinden, L | 1 |
| Vanhove, T | 1 |
| Verstuyf, M | 1 |
| Hoet, P | 1 |
| Vos, R | 1 |
| Verleden, GM | 1 |
| Vanaudenaerde, BM | 1 |
| Giménez, AR | 1 |
| Pastrana, DB | 1 |
| Huaranga, MAR | 1 |
| Izquierdo, JR | 1 |
| Cabrera, B | 1 |
| García, AN | 1 |
| Rodríguez, CCR | 1 |
| Dogra, S | 1 |
| Saini, AG | 1 |
| Suri, D | 1 |
| Rawat, A | 1 |
| Sodhi, KS | 1 |
| Singh, S | 1 |
| Speich, R | 2 |
| Schneider, S | 1 |
| Hofer, M | 1 |
| Irani, S | 1 |
| Vogt, P | 1 |
| Weder, W | 1 |
| Boehler, A | 1 |
| Bhorade, S | 1 |
| Ahya, VN | 1 |
| Baz, MA | 1 |
| Valentine, VG | 2 |
| Arcasoy, SM | 1 |
| Love, RB | 1 |
| Seethamraju, H | 1 |
| Alex, CG | 1 |
| Bag, R | 1 |
| Deoliveira, NC | 1 |
| Husain, A | 1 |
| Vigneswaran, WT | 1 |
| Charbeneau, J | 1 |
| Krishnan, JA | 1 |
| Durazo-Arvizu, R | 1 |
| Norwick, L | 1 |
| Garrity, E | 1 |
| Azzola, A | 1 |
| Havryk, A | 1 |
| Chhajed, P | 1 |
| Hostettler, K | 1 |
| Black, J | 1 |
| Johnson, P | 1 |
| Roth, M | 1 |
| Glanville, A | 2 |
| Tamm, M | 1 |
| Sarahrudi, K | 1 |
| Estenne, M | 1 |
| Corris, P | 1 |
| Niedermayer, J | 1 |
| Knoop, C | 2 |
| Chaparro, C | 1 |
| Verleden, G | 1 |
| Gerbase, MW | 1 |
| Venuta, F | 1 |
| Böttcher, H | 1 |
| Aubert, JD | 1 |
| Levvey, B | 1 |
| Reichenspurner, H | 1 |
| Auterith, A | 1 |
| Klepetko, W | 1 |
| Päiväniemi, OE | 1 |
| Maasilta, PK | 2 |
| Alho, HS | 2 |
| Wolff, CH | 1 |
| Salminen, US | 5 |
| Snell, GI | 3 |
| Vitulo, P | 2 |
| Glanville, AR | 2 |
| McGiffin, DC | 1 |
| Loyd, JE | 1 |
| Roman, A | 1 |
| Aris, R | 1 |
| Sole, A | 1 |
| Hmissi, A | 1 |
| Pirron, U | 1 |
| McNeil, K | 1 |
| Wahlers, T | 2 |
| Mamelok, RD | 1 |
| Maurer, J | 1 |
| Ives, J | 1 |
| Corris, PA | 1 |
| Cottin, V | 1 |
| Meloni, F | 1 |
| Morosini, M | 1 |
| Solari, N | 1 |
| Bini, F | 1 |
| Arbustini, E | 1 |
| Pellegrini, C | 1 |
| Fietta, AM | 1 |
| Hachem, RR | 1 |
| Yusen, RD | 1 |
| Chakinala, MM | 1 |
| Meyers, BF | 1 |
| Lynch, JP | 1 |
| Aloush, AA | 1 |
| Patterson, GA | 1 |
| Trulock, EP | 1 |
| Hsue, YT | 1 |
| Paulus, HE | 1 |
| Coulson, WF | 1 |
| Yagyu, K | 1 |
| van Breda Vriesman, PJ | 1 |
| Duijvestijn, AM | 1 |
| Bruggeman, CA | 1 |
| Steinhoff, G | 1 |
| Ross, DJ | 1 |
| Jordan, SC | 1 |
| Nathan, SD | 1 |
| Kass, RM | 1 |
| Koerner, SK | 1 |
| Esmore, DS | 1 |
| Williams, TJ | 2 |
| Ward, C | 1 |
| Wilson, JW | 1 |
| Orsida, B | 1 |
| Walters, EH | 1 |
| Uusitalo, M | 2 |
| Ikonen, T | 3 |
| Taskinen, E | 3 |
| Morris, RE | 1 |
| Harjula, AL | 4 |
| Wiebe, K | 1 |
| Harringer, W | 2 |
| Franke, U | 1 |
| Strüber, M | 1 |
| Krug, N | 1 |
| Korff, F | 1 |
| Cremer, J | 1 |
| Haverich, A | 2 |
| Korpela, A | 1 |
| Maasilta, P | 2 |
| Alho, H | 1 |
| Taskinen, EI | 1 |
| Ikonen, TS | 1 |
| Hoffmeyer, F | 1 |
| Hoeper, MM | 1 |
| Spiekerkötter, E | 1 |
| Fabel, H | 1 |
| Niedermeyer, J | 1 |
| Streichenberger, N | 1 |
| Peyrol, S | 1 |
| Philit, F | 1 |
| Loire, R | 1 |
| Sommer, P | 1 |
| Cordier, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of a Tacrolimus/Sirolimus/Prednisone Regimen Versus Tacrolimus/Azathioprine/Prednisone Immunosuppressive Regimen in Lung Transplantation[NCT00321906] | Phase 4 | 181 participants (Actual) | Interventional | 2002-04-30 | Completed | ||
| Randomized, Open-label, Multi-Center Study Comparing Tacrolimus With Cyclosporin, Both Arms in Combination With Mycophenolate Mofetil and Corticosteroids for Prevention of Bronchiolitis Obliterans Syndrome in Lung Transplant Patients[NCT01429844] | Phase 3 | 274 participants (Actual) | Interventional | 2001-01-31 | Completed | ||
| The Role Of Endoscopic Alveoscopy by Confocal Endomicroscopy in Diagnosing Acute and Chronic Rejection in Lung Transplant Recipients, Diagnosis of End Stage Lung Disease, and Other Pulmonary Pathologies in Vivo[NCT01033201] | 71 participants (Actual) | Observational | 2008-04-30 | Completed | |||
| Prospective and Retrospective Study to Develop a Multi-center Randomized Study, to Determine if Prevention of GERD Related Aspiration by Surgical Fundoplication Improves Lung Allograft Function[NCT01406210] | 647 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Raw proportion of patients that experienced acute rejection at or before 12 months. (NCT00321906)
Timeframe: 12mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 48 |
| Sirolimus | 39 |
"Kaplan-Meier estimate of proportion of patients that had not experienced acute rejection by 12 months. Acute rejection is defined as rejection at any of the following grades.~Grade A0 - None With/Without Grade A1 - Minimal Grade A2 - Mild Grade A3 - Moderate" (NCT00321906)
Timeframe: 12 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 56 |
| Sirolimus | 58 |
Kaplan-Meier estimate of proportion of patients that had not experienced BOS by 24 months. (NCT00321906)
Timeframe: 24 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 81 |
| Sirolimus | 78 |
Kaplan-Meier estimate of proportion of patients that had not experienced BOS by 36 months. (NCT00321906)
Timeframe: 36 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 76 |
| Sirolimus | 72 |
Kaplan-Meier estimate of proportion of patients that survived to (i.e., had not died by) 12 months. (NCT00321906)
Timeframe: 12 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 97 |
| Sirolimus | 97 |
Kaplan-Meier estimate of proportion of patients that survived to (i.e., had not died by) 24 months. (NCT00321906)
Timeframe: 24 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 89 |
| Sirolimus | 94 |
Kaplan-Meier estimate of proportion of patients that survived to (i.e., had not died by) 36 months. (NCT00321906)
Timeframe: 36 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 84 |
| Sirolimus | 87 |
"Raw proportion of patients that experienced rejection at or above grade A2 by 12 months.~Grade A0 - None With/Without Grade A1 - Minimal Grade A2 - Mild Grade A3 - Moderate" (NCT00321906)
Timeframe: 12 mos
| Intervention | percentage of participants (Number) |
|---|---|
| Azathioprine | 24 |
| Sirolimus | 18 |
1 review available for azathioprine and Bronchiolitis, Exudative
| Article | Year |
|---|---|
[Idiopathic interstitial pneumonia: treatment].
Topics: Acetylcysteine; Acute Disease; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Azathioprine; Benz | 2006 |
6 trials available for azathioprine and Bronchiolitis, Exudative
| Article | Year |
|---|---|
Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation.
Topics: Azathioprine; Bronchiolitis Obliterans; Drug Therapy, Combination; Graft Rejection; Humans; Immunosu | 2011 |
Everolimus versus azathioprine in maintenance lung transplant recipients: an international, randomized, double-blind clinical trial.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bronchiolitis Obliterans; Cyclosporine; Double-Blind M | 2006 |
Comparison of mycophenolate mofetil and azathioprine for prevention of bronchiolitis obliterans syndrome in de novo lung transplant recipients.
Topics: Adolescent; Adult; Aged; Azathioprine; Bronchiolitis Obliterans; Drug Therapy, Combination; Graft Re | 2006 |
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.
Topics: Adult; Azathioprine; Bronchiolitis Obliterans; Bronchitis; Cyclosporine; Diabetes Mellitus; Drug The | 2007 |
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.
Topics: Adult; Azathioprine; Bronchiolitis Obliterans; Bronchitis; Cyclosporine; Diabetes Mellitus; Drug The | 2007 |
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.
Topics: Adult; Azathioprine; Bronchiolitis Obliterans; Bronchitis; Cyclosporine; Diabetes Mellitus; Drug The | 2007 |
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation.
Topics: Adult; Azathioprine; Bronchiolitis Obliterans; Bronchitis; Cyclosporine; Diabetes Mellitus; Drug The | 2007 |
FK506 rescue therapy in lung transplantation.
Topics: Azathioprine; Bronchiolitis Obliterans; Cyclosporine; Drug Therapy, Combination; Graft Rejection; He | 1998 |
Azathioprine withdrawal in stable lung and heart/lung recipients receiving cyclosporine-based immunosuppression.
Topics: Acute Disease; Adult; Azathioprine; Bronchiolitis Obliterans; Cyclosporine; Cytomegalovirus Infectio | 2000 |
18 other studies available for azathioprine and Bronchiolitis, Exudative
| Article | Year |
|---|---|
The Effect of Immunosuppression on Airway Integrity.
Topics: Azathioprine; Bronchiolitis Obliterans; Cyclosporine; Dexamethasone; Endothelial Cells; Epithelial C | 2017 |
Belimumab in refractory organizing pneumonia associated with systemic lupus erythematosus: a case report.
Topics: Antibodies, Antinuclear; Antibodies, Monoclonal, Humanized; Azathioprine; Bronchiolitis Obliterans; | 2019 |
Bronchiolitis obliterans associated with Stevens-Johnson syndrome and response to azathioprine.
Topics: Azathioprine; Bronchiolitis Obliterans; Child; Humans; Immunosuppressive Agents; Male; Remission Ind | 2014 |
Mycophenolate mofetil reduces alveolar inflammation, acute rejection and graft loss due to bronchiolitis obliterans syndrome after lung transplantation.
Topics: Adult; Azathioprine; Bronchiolitis Obliterans; Bronchoalveolar Lavage Fluid; Female; Graft Rejection | 2010 |
Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation.
Topics: Adult; Aged; Azathioprine; Bronchi; Bronchiolitis Obliterans; Cell Division; Cells, Cultured; Cyclos | 2004 |
International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection.
Topics: Acute Disease; Adult; Australia; Azathioprine; Bronchiolitis Obliterans; Canada; Chronic Disease; Cy | 2004 |
Cyclooxygenase-2 expression in experimental post-transplant obliterative bronchiolitis.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Chondrocytes; Cyclooxygenase 2; Cyclospori | 2004 |
Peripheral CD4+ CD25+ Treg cell expansion in lung transplant recipients is not affected by calcineurin inhibitors.
Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Azathioprine; Bronchiolitis Obli | 2006 |
Bronchiolitis obliterans organizing pneumonia in polymyositis. A case report with longterm survival.
Topics: Adult; Azathioprine; Bronchi; Bronchiolitis Obliterans; Female; Humans; Lung; Pneumonia; Polymyositi | 1993 |
Reactivation of cytomegalovirus with acute rejection and cytomegalovirus infection with obliterative bronchiolitis in rat lung allografts.
Topics: Animals; Azathioprine; Bronchiolitis Obliterans; Cyclosporine; Cytomegalovirus Infections; Graft Rej | 1993 |
Delayed development of obliterative bronchiolitis syndrome with OKT3 after unilateral lung transplantation. A plea for multicenter immunosuppressive trials.
Topics: Acute Disease; Antilymphocyte Serum; Azathioprine; Biopsy; Bronchiolitis Obliterans; Bronchoscopy; C | 1996 |
Cytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation.
Topics: Adult; Anti-Inflammatory Agents; Antibiotic Prophylaxis; Antilymphocyte Serum; Azathioprine; Bronchi | 1996 |
Immunopathological changes in the airways of stable lung transplant recipients.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Biopsy; Bronchiolitis; Bronchiolitis Obliterans; Cycl | 1997 |
Effect of immunosuppression on obliterative lesions in a heterotopic large-animal bronchial allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Cartilage; Cyclosporine; Drug Therapy, Com | 1997 |
Obliterative lesions in small airways in an immunosuppressed porcine heterotopic bronchial allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Cyclosporine; Disease Models, Animal; Immu | 1998 |
Effects of rapamycin analogue SDZ RAD on obliterative lesions in a porcine heterotopic bronchial allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Cartilage; Cyclosporine; Epithelium; Evero | 1998 |
Prevention of small airway obliteration in a swine heterotopic lung allograft model.
Topics: Animals; Azathioprine; Bronchi; Bronchiolitis Obliterans; Disease Models, Animal; Epithelium; Everol | 2000 |
Constrictive bronchiolitis obliterans. Characterisation of fibrogenesis and lysyl oxidase expression patterns.
Topics: Adult; Azathioprine; Biomarkers; Bone Marrow Transplantation; Bronchiolitis Obliterans; Drug Therapy | 2001 |