azathioprine has been researched along with Bone Marrow Diseases in 52 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Bone Marrow Diseases: Diseases involving the BONE MARROW.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine may be tried for treatment of severe myasthenia gravis, in a dose of 2 mg/kg BW." | 7.67 | Immunosuppressive drugs: azathioprine in the treatment of myasthenia gravis. ( Matell, G, 1987) |
| "Azathioprine can cause severe myelosuppression." | 5.29 | Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. ( Ben Ari, Z; Burroughs, AK; Lennard, L; Mehta, A, 1995) |
| "Azathioprine may be tried for treatment of severe myasthenia gravis, in a dose of 2 mg/kg BW." | 3.67 | Immunosuppressive drugs: azathioprine in the treatment of myasthenia gravis. ( Matell, G, 1987) |
| " They were treated with 50 mg/day of AZA, and we evaluated the remission rate at 6 months, adverse side effects, and changes in prednisone doses after the initiation of AZA." | 2.71 | Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. ( Hibi, T; Kinjyo, F; Kitahora, T; Naganuma, M; Shimoyama, T, 2003) |
| " The purpose of this study was to explore the association between these polymorphisms and the occurrence of azathioprine adverse effects in 112 renal transplant recipients undergoing triple immunosuppressive therapy including azathioprine, cyclosporine, and prednisone." | 2.71 | The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients. ( Domański, L; Droździk, M; Dziewanowski, K; Gawrońska-Szklarz, B; Kurzawski, M, 2005) |
| "Azathioprine has been in use for decades as an immunosuppressant treatment for various autoimmune diseases." | 2.45 | TPMT testing before azathioprine therapy? ( , 2009) |
| "Probably, the most important and potentially lethal adverse event of azathioprine (AZA) and mercaptopurine (MP) is myelosuppression." | 2.44 | Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review. ( Gisbert, JP; Gomollón, F, 2008) |
| " However, treatment is limited by adverse events-in particular, myelotoxicity." | 1.72 | TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results. ( Anandi, P; Birdwell, KA; Chung, CP; Cox, NJ; Dale Plummer, W; Daniel, LL; Dickson, AL; Dupont, WD; Feng, Q; Hung, AM; Kawai, V; Liu, G; Reese, T; Stein, CM; Wei, WQ; Zanussi, J, 2022) |
| "The drugs prescribed for the treatment of autoimmune diseases, including azathioprine/6-MP, modified TPMT activity, but the magnitude of this effect was very small and the differences found are probably irrelevant from the clinical point of view." | 1.34 | Thiopurine methyltransferase activity in Spain: a study of 14,545 patients. ( Cara, C; Gisbert, JP; Gomollón, F; González-Lama, Y; Guijarro, LG; Luna, M; Maté, J; Pajares, JM, 2007) |
| "61); among the 34 responders, the median dosage of the drug required to obtain remission was lower for mutated than for wild type patients (1." | 1.33 | TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease. ( Barabino, A; Bartoli, F; Decorti, G; Fezzi, M; Fontana, M; Giraldi, T; Lionetti, P; Malusà, N; Martelossi, S; Stocco, G; Ventura, A, 2005) |
| "To prospectively evaluate whether a relationship between thiopurine methyltransferase (TPMT) activity and incidence of adverse effects (especially myelotoxicity) exists, in a long-term follow-up study of a large group of patients with inflammatory bowel disease treated with azathioprine." | 1.33 | Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. ( Cara, C; Gisbert, JP; Guijarro, LG; Niño, P; Rodrigo, L, 2006) |
| "Isolated thrombocytopenia was never clinically severe." | 1.29 | Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience. ( Connell, WR; Kamm, MA; Lennard-Jones, JE; Ritchie, JK, 1993) |
| "Azathioprine can cause severe myelosuppression." | 1.29 | Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. ( Ben Ari, Z; Burroughs, AK; Lennard, L; Mehta, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (53.85) | 18.7374 |
| 1990's | 5 (9.62) | 18.2507 |
| 2000's | 9 (17.31) | 29.6817 |
| 2010's | 7 (13.46) | 24.3611 |
| 2020's | 3 (5.77) | 2.80 |
| Authors | Studies |
|---|---|
| Dickson, AL | 1 |
| Daniel, LL | 1 |
| Zanussi, J | 1 |
| Dale Plummer, W | 1 |
| Wei, WQ | 1 |
| Liu, G | 1 |
| Reese, T | 1 |
| Anandi, P | 1 |
| Birdwell, KA | 1 |
| Kawai, V | 1 |
| Cox, NJ | 1 |
| Dupont, WD | 1 |
| Hung, AM | 1 |
| Feng, Q | 1 |
| Stein, CM | 1 |
| Chung, CP | 1 |
| Jiang, N | 1 |
| Jin, S | 1 |
| Yu, C | 1 |
| Zhao, J | 1 |
| Wang, Q | 1 |
| Tian, X | 1 |
| Li, M | 1 |
| Zeng, X | 1 |
| Zarca, K | 1 |
| Chansavang, A | 1 |
| Loriot, MA | 1 |
| Durand-Zaleski, I | 1 |
| Pallet, N | 1 |
| Yan, W | 1 |
| Zhou, YH | 1 |
| Wang, L | 1 |
| Xiao, J | 1 |
| Li, W | 1 |
| Yang, X | 1 |
| Xu, H | 1 |
| Yang, J | 1 |
| Yang, L | 1 |
| Ruiz Hernández, C | 1 |
| Sánchez Hernández, D | 1 |
| Vila Miravet, V | 1 |
| Pinillos Pisón, S | 1 |
| Martin de Carpi, J | 1 |
| Gisbert, JP | 3 |
| Gomollón, F | 2 |
| Wee, JS | 1 |
| Marinaki, A | 1 |
| Smith, CH | 1 |
| Thiryayi, WA | 1 |
| Meggitt, SJ | 1 |
| Anstey, AV | 1 |
| Mohd Mustapa, MF | 1 |
| Reynolds, NJ | 1 |
| Wakelin, S | 1 |
| Millán, M | 1 |
| Castro-Fernández, M | 1 |
| Ampuero, J | 1 |
| Romero-Gómez, M | 1 |
| Hibi, T | 1 |
| Naganuma, M | 1 |
| Kitahora, T | 1 |
| Kinjyo, F | 1 |
| Shimoyama, T | 1 |
| Kurzawski, M | 1 |
| Dziewanowski, K | 1 |
| Gawrońska-Szklarz, B | 1 |
| Domański, L | 1 |
| Droździk, M | 1 |
| Stocco, G | 1 |
| Martelossi, S | 1 |
| Barabino, A | 1 |
| Fontana, M | 1 |
| Lionetti, P | 1 |
| Decorti, G | 1 |
| Malusà, N | 1 |
| Bartoli, F | 1 |
| Fezzi, M | 1 |
| Giraldi, T | 1 |
| Ventura, A | 1 |
| Gardiner, SJ | 1 |
| Gearry, RB | 1 |
| Barclay, ML | 1 |
| Begg, EJ | 1 |
| Niño, P | 1 |
| Rodrigo, L | 1 |
| Cara, C | 2 |
| Guijarro, LG | 2 |
| Luna, M | 1 |
| González-Lama, Y | 1 |
| Pajares, JM | 1 |
| Maté, J | 1 |
| Richard, VS | 1 |
| Al-Ismail, D | 1 |
| Salamat, A | 1 |
| Lawson, DH | 1 |
| Lovatt, GE | 1 |
| Gurton, CS | 1 |
| Hennings, RC | 1 |
| Geary, CG | 1 |
| Fasshauer, K | 1 |
| Rath, I | 1 |
| Zazgornik, J | 1 |
| Kopsa, H | 1 |
| Schmidt, P | 1 |
| Pils, P | 1 |
| Kuschan, K | 1 |
| Deutsch, E | 1 |
| Mircheva, J | 1 |
| Legendre, C | 1 |
| Soria-Royer, C | 1 |
| Thervet, E | 1 |
| Beaune, P | 1 |
| Kreis, H | 1 |
| Connell, WR | 1 |
| Kamm, MA | 1 |
| Ritchie, JK | 1 |
| Lennard-Jones, JE | 1 |
| Ben Ari, Z | 1 |
| Mehta, A | 1 |
| Lennard, L | 2 |
| Burroughs, AK | 1 |
| Rinkardt, NE | 1 |
| Kruth, SA | 1 |
| Hansi, W | 1 |
| Heimpel, H | 1 |
| McGrath, BP | 1 |
| Ibels, LS | 1 |
| Raik, E | 1 |
| Hargrave, MJ | 1 |
| Venkat Raman, G | 1 |
| Sharman, VL | 2 |
| Lee, HA | 1 |
| Maddocks, JL | 1 |
| Amess, J | 1 |
| Amos, R | 1 |
| Thomas, RM | 1 |
| Matell, G | 1 |
| Slapak, M | 1 |
| Geoghegan, T | 1 |
| Digard, N | 1 |
| Ahmed, K | 1 |
| Crockett, R | 1 |
| Noeske, K | 1 |
| Wallnöfer, H | 1 |
| Täuber, K | 1 |
| Hattersley, PG | 1 |
| Thumb, N | 1 |
| Blichfeldt, P | 1 |
| Ahn, YS | 1 |
| Harrington, WJ | 1 |
| Seelman, RC | 1 |
| Eytel, CS | 1 |
| Currey, HL | 1 |
| Bach, JF | 2 |
| Dardenne, M | 2 |
| Rao, MM | 1 |
| Meadows, R | 1 |
| Rao, MD | 1 |
| Knight, PR | 1 |
| Grob, PJ | 1 |
| Michot, F | 1 |
| Krug, K | 1 |
| Kettner, W | 1 |
| Nies, AS | 1 |
| Oates, JA | 1 |
| Swannell, AJ | 1 |
| Kersley, GD | 1 |
| Kölle, G | 1 |
| Wiontzek, H | 1 |
| Penn, I | 1 |
6 reviews available for azathioprine and Bone Marrow Diseases
| Article | Year |
|---|---|
Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis.
Topics: Adult; Azathioprine; Bone Marrow Diseases; Cyclophosphamide; Glucocorticoids; Herpes Zoster; Humans; | 2023 |
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review.
Topics: Azathioprine; Bone Marrow Diseases; Humans; Inflammatory Bowel Diseases; Leukopenia; Mercaptopurine | 2008 |
TPMT testing before azathioprine therapy?
Topics: Azathioprine; Bone Marrow Diseases; Clinical Enzyme Tests; Cost-Benefit Analysis; Humans; Immunosupp | 2009 |
Adverse effects of azathioprine.
Topics: Alopecia; Azathioprine; Bone Marrow Diseases; Carcinogens; Drug Hypersensitivity; Drug Interactions; | 1984 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; | 1970 |
[Current status of immunosuppressive therapy in non-neoplastic disorders].
Topics: Arthritis; Autoimmune Diseases; Azathioprine; Bone Marrow; Bone Marrow Diseases; Chemical Phenomena; | 1970 |
4 trials available for azathioprine and Bone Marrow Diseases
| Article | Year |
|---|---|
Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis.
Topics: Adult; Azathioprine; Bone Marrow Diseases; Colitis, Ulcerative; Dose-Response Relationship, Drug; Fe | 2003 |
The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.
Topics: Adolescent; Adult; Aged; Alleles; Azathioprine; Bone Marrow Diseases; Child; Cyclosporine; Dose-Resp | 2005 |
[Immunosuppressive therapy chronic polyarthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Chlorambucil; Clinical Trial | 1972 |
Treatment of rheumatoid arthritis with cytotoxic and antimetabolic drugs.
Topics: Alopecia; Aminopterin; Antimetabolites; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; | 1970 |
43 other studies available for azathioprine and Bone Marrow Diseases
| Article | Year |
|---|---|
TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Bone Marrow Diseases; Cohort Studies; Female; Humans; | 2022 |
Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles.
Topics: Asian People; Azathioprine; Bone Marrow Diseases; Cost-Benefit Analysis; Decision Trees; Drug Hypers | 2020 |
NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a Chinese man with pemphigus vulgaris.
Topics: Azathioprine; Bone Marrow Diseases; Humans; Immunosuppressive Agents; Male; Middle Aged; Myelopoiesi | 2018 |
Rare gene variants in a patient with azathioprine-induced lethal myelosuppression.
Topics: Azathioprine; Bone Marrow Diseases; Cholangitis, Sclerosing; Ethnicity; Genetic Predisposition to Di | 2017 |
[Bone marrow toxicity secondary to a primary Epstein-Barr infection in a patient with Crohn's disease on thiopurines treatment].
Topics: Adolescent; Azathioprine; Bone Marrow Diseases; Crohn Disease; Epstein-Barr Virus Infections; Humans | 2015 |
Life threatening myelotoxicity secondary to azathioprine in a patient with atopic eczema and normal thiopurine methyltransferase activity.
Topics: Adult; Azathioprine; Bone Marrow Diseases; Dermatitis, Atopic; Humans; Immunosuppressive Agents; Mal | 2011 |
Clinically integrated care. Shared care/blame arrangements.
Topics: Azathioprine; Bone Marrow Diseases; Dermatitis, Atopic; Drug Monitoring; Humans; Immunosuppressive A | 2011 |
British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011.
Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Bone Marrow Diseases; Chemical and Drug Indu | 2011 |
[Myelotoxicity due to interaction between azathioprine and allopurinol in a patient with Crohn's disease].
Topics: Aged; Allopurinol; Azathioprine; Biotransformation; Bone Marrow Diseases; Crohn Disease; Drug Intera | 2013 |
TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child | 2005 |
Two cases of thiopurine methyltransferase (TPMT) deficiency--a lucky save and a near miss with azathioprine.
Topics: Adult; Aged; Azathioprine; Bone Marrow Diseases; Humans; Immunosuppressive Agents; Male; Methyltrans | 2006 |
Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.
Topics: Adult; Azathioprine; Bone Marrow Diseases; Drug Administration Schedule; Female; Follow-Up Studies; | 2006 |
Thiopurine methyltransferase activity in Spain: a study of 14,545 patients.
Topics: Adult; Autoimmune Diseases; Azathioprine; Bone Marrow Diseases; Erythrocytes; Female; Humans; Immuno | 2007 |
Should we test TPMT enzyme levels before starting azathioprine?
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Diagnostic Tests, Routine; Female; | 2007 |
Lymphoma and leukaemia due to drugs.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Bone Marrow Diseases; Child; Female; Hodgkin Disease; | 1980 |
[Comments on the indication of immunosuppressive long-term therapy in myasthenia gravis (author's transl)].
Topics: Azathioprine; Bone Marrow Diseases; Cholestasis, Intrahepatic; Cholinesterase Inhibitors; Humans; Jo | 1981 |
Increased danger of bone marrow damage in simultaneous azathioprine-allopurinol therapy.
Topics: Adult; Allopurinol; Azathioprine; Bone Marrow Diseases; Drug Therapy, Combination; Female; Humans | 1981 |
Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.
Topics: Azathioprine; Bone Marrow Diseases; Erythrocytes; Evaluation Studies as Topic; Genotype; Glutathione | 1995 |
Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.
Topics: Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Diseases; Female; Humans; Inflammatory Bow | 1993 |
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
Topics: Adult; Autoimmune Diseases; Azathioprine; Bone Marrow Diseases; Hepatitis; Humans; Immunosuppressive | 1995 |
Azathioprine-induced bone marrow toxicity in four dogs.
Topics: Anemia, Hemolytic; Animals; Azathioprine; Bone Marrow; Bone Marrow Diseases; Dog Diseases; Dogs; Fem | 1996 |
[Treatment of panmyelopathies].
Topics: Androgens; Anti-Bacterial Agents; Antilymphocyte Serum; Azathioprine; Blood Platelets; Blood Transfu | 1979 |
Erythroid toxicity of azathioprin. Macrocytosis and selective marrow hypoplasis.
Topics: Adult; Azathioprine; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Creatinine; Dose-Response | 1975 |
Azathioprine and allopurinol: a potentially dangerous combination.
Topics: Adolescent; Adult; Allopurinol; Azathioprine; Bone Marrow Diseases; Drug Interactions; Female; Human | 1990 |
Azathioprine and severe bone marrow depression.
Topics: Acute Disease; Azathioprine; Bone Marrow Diseases; Female; Guanine Nucleotides; Humans; Middle Aged; | 1986 |
Immunosuppressive drugs: azathioprine in the treatment of myasthenia gravis.
Topics: Azathioprine; Bone Marrow Diseases; Drug Evaluation; Female; Gastrointestinal Diseases; Humans; Male | 1987 |
The use of low-dose cyclosporine A in combination with azathioprine and steroids in renal transplantation.
Topics: Adult; Azathioprine; Bone Marrow Diseases; Cadaver; Cyclosporins; Dose-Response Relationship, Drug; | 1987 |
[Histological and histometrical studies of azathioprine-induced bone marrow lesions in rats (author's transl)].
Topics: Animals; Azathioprine; Bone Marrow Cells; Bone Marrow Diseases; Cytological Techniques; Hematopoiesi | 1972 |
[Panmyelopathy after viral hepatitis].
Topics: Adrenocorticotropic Hormone; Adult; Antigen-Antibody Reactions; Autoimmune Diseases; Azathioprine; B | 1970 |
Letter: Macrocytosis and cyclophosphamide.
Topics: Azathioprine; Bone Marrow Diseases; Cyclophosphamide; Erythrocytes; Humans | 1974 |
[Drug therapy in juvenile rheumatoid arthritis. Experiences with azathioprine].
Topics: Arthritis, Juvenile; Azathioprine; Bone Marrow Diseases; Child; Child, Preschool; Female; Fever; Hum | 1974 |
Vincristine therapy of idiopathic and secondary thrombocytopenias.
Topics: Adult; Aged; Azathioprine; Blood Cell Count; Blood Platelets; Bone Marrow Diseases; Child; Cyclophos | 1974 |
The metabolism of azathioprine in renal failure.
Topics: Acute Kidney Injury; Azathioprine; Bone Marrow Diseases; Hemagglutination Tests; Humans; Immunosuppr | 1971 |
The effect of 9-butyl azathioprine on canine renal homograft survival.
Topics: Animals; Azathioprine; Body Weight; Bone Marrow Diseases; Dogs; Graft Rejection; Histocompatibility; | 1971 |
[Experiences in the long term treatment of collagen diseases with azathioprine (imuran)].
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Blood Cell Count; Bone Marrow Disea | 1968 |
[Studies on the metabolism of azathioprine].
Topics: Animals; Antigen-Antibody Reactions; Azathioprine; Bone Marrow Diseases; Erythrocytes; Humans; In Vi | 1970 |
[Diagnosis, therapy and prognosis of the chronic cold agglutinin disease].
Topics: Adult; Anemia, Hemolytic; Azathioprine; Blood Transfusion; Bone Marrow Diseases; Chronic Disease; Cr | 1970 |
[Treatment of ulcerative colitis with azathioprine].
Topics: Aged; Azathioprine; Bone Marrow Diseases; Colitis, Ulcerative; Female; Humans; Male | 1971 |
Clinicopathologic conference: hypertension and the lupus syndrome--revisited.
Topics: Allopurinol; Azathioprine; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Drug Interactions; H | 1971 |
Preliminary results with azathioprine treatment in rheumatoid arthritis.
Topics: Alkaline Phosphatase; Arthritis, Rheumatoid; Azathioprine; Bone Marrow Diseases; Drug Synergism; Fem | 1969 |
[Bone marrow damage following immunosuppressive therapy with azathioprine of juvenile rheumatoid arthritis and the Still syndrome].
Topics: Adolescent; Agranulocytosis; Arthritis, Juvenile; Azathioprine; Bone Marrow Diseases; Bone Marrow Ex | 1969 |
[Panmyelopathy after viral hepatitis. Comment to H. Wallnöfer, K. Tauber: Med. Klin. 65 (1970), 159].
Topics: Aminopyrine; Asthma; Azathioprine; Bone Marrow Diseases; Chloramphenicol; Female; Hepatitis A; Human | 1970 |
Complications of immunosuppression.
Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Bone Marrow Diseases; Humans; Immunosup | 1971 |