azathioprine has been researched along with Bile Duct Obstruction, Intrahepatic in 16 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy." | 9.41 | Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. ( Akria, L; Carmiel Haggai, M; Frank Wolf, M; Lowenstein, L; Rimon, E; Sloma, R; Wiener, Y, 2023) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 7.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| "Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy." | 5.41 | Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature. ( Akria, L; Carmiel Haggai, M; Frank Wolf, M; Lowenstein, L; Rimon, E; Sloma, R; Wiener, Y, 2023) |
| "MODE OF ACTION OF URSODEOXYCHOLIC ACID: In cholestasis, the impaired biliary secretion of toxic bile acids causes their accumulation in the liver and a subsequent hepatic failure." | 4.81 | [Treatment of cholestatic liver diseases]. ( Gatzen, M; Pausch, J, 2002) |
| " Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case." | 3.70 | Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999) |
| "A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy." | 3.68 | Reversible cholestasis with bile duct injury following azathioprine therapy. A case report. ( Geubel, AP; Horsmans, Y; Rahier, J, 1991) |
| "Azathioprine is a drug commonly used for the treatment of inflammatory bowel disease, organ transplantation and various autoimmune diseases." | 2.40 | Cholestatic hepatocellular injury with azathioprine: a case report and review of the mechanisms of hepatotoxicity. ( Jewell, L; Lalor, E; Romagnuolo, J; Sadowski, DC; Thomson, AB, 1998) |
| "Azathioprine was withdrawn." | 1.36 | Azathioprine-induced severe cholestatic hepatitis in patient carrying TPMT*3C polymorphism. ( Belajouza, C; Ben Salah, L; Ben Salem, C; Bouraoui, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (31.25) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Frank Wolf, M | 1 |
| Sloma, R | 1 |
| Akria, L | 1 |
| Rimon, E | 1 |
| Wiener, Y | 1 |
| Carmiel Haggai, M | 1 |
| Lowenstein, L | 1 |
| Céruti, H | 1 |
| Kayem, G | 1 |
| Guilbaud, L | 1 |
| Dussaux, C | 1 |
| Gervais, A | 1 |
| Beaufrère, A | 1 |
| Coffin, B | 1 |
| Mandelbrot, L | 1 |
| Maisonneuve, E | 1 |
| Roda, G | 1 |
| Caponi, A | 1 |
| Belluzzi, A | 1 |
| Roda, E | 1 |
| Ben Salem, C | 1 |
| Ben Salah, L | 1 |
| Belajouza, C | 1 |
| Bouraoui, K | 1 |
| Eisenbach, C | 1 |
| Goeggelmann, C | 1 |
| Flechtenmacher, C | 1 |
| Stremmel, W | 1 |
| Encke, J | 1 |
| Teruel, JL | 1 |
| Marcén, R | 1 |
| Celma, ML | 1 |
| Bueno, R | 1 |
| Jiménez del Cerro, L | 1 |
| Matesanz, R | 1 |
| Quereda, C | 1 |
| Ortuño, J | 1 |
| Fasshauer, K | 1 |
| Rath, I | 1 |
| Hizawa, N | 1 |
| Kojima, J | 1 |
| Kojima, T | 1 |
| Sukoh, N | 1 |
| Yamaguchi, E | 1 |
| Kawakami, Y | 1 |
| Matsushima, T | 1 |
| Romagnuolo, J | 1 |
| Sadowski, DC | 1 |
| Lalor, E | 1 |
| Jewell, L | 1 |
| Thomson, AB | 1 |
| Delladetsima, JK | 1 |
| Boletis, JN | 1 |
| Makris, F | 1 |
| Psichogiou, M | 1 |
| Kostakis, A | 1 |
| Hatzakis, A | 1 |
| Delgado, J | 1 |
| Muñoz de Bustillo, E | 1 |
| Ibarrola, C | 1 |
| Colina, F | 1 |
| Morales, JM | 1 |
| Rodriguez, E | 1 |
| Aguado, JM | 1 |
| Fuertes, A | 1 |
| Gomez, MA | 1 |
| Gatzen, M | 1 |
| Pausch, J | 1 |
| Horsmans, Y | 1 |
| Rahier, J | 1 |
| Geubel, AP | 1 |
| Wakabayashi, T | 1 |
| Mori, S | 1 |
| Pastolero, J | 1 |
| Sugimura, H | 1 |
| Mendel, R | 1 |
| Hebestreit, HP | 1 |
| Droste, R | 1 |
| Bade, J | 1 |
| Georgi, M | 1 |
| Sparberg, M | 1 |
| Simon, N | 1 |
| del Greco, F | 1 |
3 reviews available for azathioprine and Bile Duct Obstruction, Intrahepatic
| Article | Year |
|---|---|
Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature.
Topics: Azathioprine; Cholestasis, Intrahepatic; Female; Humans; Mercaptopurine; Pregnancy; Pregnancy Compli | 2023 |
Cholestatic hepatocellular injury with azathioprine: a case report and review of the mechanisms of hepatotoxicity.
Topics: Azathioprine; Cholestasis, Intrahepatic; Crohn Disease; Drug Hypersensitivity; Humans; Immunosuppres | 1998 |
[Treatment of cholestatic liver diseases].
Topics: Adult; Age Factors; Anti-Inflammatory Agents; Azathioprine; Bile; Child; Cholagogues and Choleretics | 2002 |
13 other studies available for azathioprine and Bile Duct Obstruction, Intrahepatic
| Article | Year |
|---|---|
Intrahepatic cholestasis of pregnancy associated with azathioprine: A case series.
Topics: Adult; Azathioprine; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; C | 2021 |
Severe cholestatic acute hepatitis following azathioprine therapy in a patient with ulcerative pancolitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Cholestasis, Intrahepatic; Colitis, Ulcerativ | 2009 |
Azathioprine-induced severe cholestatic hepatitis in patient carrying TPMT*3C polymorphism.
Topics: Adult; Azathioprine; Cholestasis, Intrahepatic; Follow-Up Studies; Genetic Carrier Screening; Hetero | 2010 |
Severe cholestatic hepatitis caused by azathioprine.
Topics: Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Liver | 2005 |
[Hepatopathy in kidney transplant patients: incidence, etiology and clinical forms of presentation].
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytomegalovirus Inf | 1984 |
[Comments on the indication of immunosuppressive long-term therapy in myasthenia gravis (author's transl)].
Topics: Azathioprine; Bone Marrow Diseases; Cholestasis, Intrahepatic; Cholinesterase Inhibitors; Humans; Jo | 1981 |
A patient with chronic hepatitis C who simultaneously developed interstitial pneumonia, hemolytic anemia and cholestatic liver dysfunction after alpha-interferon administration.
Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Cholestasis, Intrahepatic; Female; Hepatitis C; Humans; | 1994 |
Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection.
Topics: Adult; Alanine Transaminase; Azathioprine; Biopsy; Cholestasis, Intrahepatic; Cyclosporine; Fatal Ou | 1999 |
Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor?
Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatal Outcome; Hear | 1999 |
Reversible cholestasis with bile duct injury following azathioprine therapy. A case report.
Topics: Azathioprine; Bile Ducts, Intrahepatic; Biopsy; Cholestasis, Intrahepatic; Humans; Male; Middle Aged | 1991 |
Bile ductal and ductular changes of the livers in the renal allografted patients.
Topics: Adult; Azathioprine; Bile Ducts, Intrahepatic; Biopsy, Needle; Chemical and Drug Induced Liver Injur | 1987 |
[2 cases of primary sclerosing cholangitis--the ERCP documentation of a 3-year course of immunosuppressive therapy].
Topics: Adult; Azathioprine; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Cholestasis, Intr | 1985 |
Intrahepatic cholestasis due to azathioprine.
Topics: Adult; Azathioprine; Cholestasis, Intrahepatic; Humans; Kidney Transplantation; Male; Postoperative | 1969 |