azathioprine has been researched along with Bacteremia in 11 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Excerpt | Relevance | Reference |
---|---|---|
"We describe a case of 36-year-old Japanese man with Crohn's disease, complicated by Bacillus cereus bacteremia on maintenance azathioprine therapy." | 7.75 | [Bacillus cereus bacteremia in Crohn's disease with multiple ileal stricture on maintenance azathioprine therapy]. ( Hizawa, K; Iida, M; Matsumoto, T; Nagata, Y; Nakamori, M; Taniguchi, M, 2009) |
"We describe a case of 36-year-old Japanese man with Crohn's disease, complicated by Bacillus cereus bacteremia on maintenance azathioprine therapy." | 3.75 | [Bacillus cereus bacteremia in Crohn's disease with multiple ileal stricture on maintenance azathioprine therapy]. ( Hizawa, K; Iida, M; Matsumoto, T; Nagata, Y; Nakamori, M; Taniguchi, M, 2009) |
"In an open-label study, 6 patients with moderately active SLE (4 with nephritis and 3 with arthritis refractory to other therapies) were given 4 300-mg doses of infliximab, a chimeric anti-TNFalpha antibody, in addition to immunosuppression with azathioprine or methotrexate." | 3.72 | Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. ( Aringer, M; Graninger, WB; Smolen, JS; Steiner, G, 2004) |
"All p values were less than 0." | 1.48 | Invasive aspergillosis in patients with systemic lupus erythematosus: a retrospective study on clinical characteristics and risk factors for mortality. ( Chang, DM; Chen, MH; Chen, WS; Hung, ML; Lai, CC; Liao, HT; Tsai, CY, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (18.18) | 18.2507 |
2000's | 4 (36.36) | 29.6817 |
2010's | 5 (45.45) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Hung, ML | 1 |
Liao, HT | 1 |
Chen, WS | 1 |
Chen, MH | 1 |
Lai, CC | 1 |
Tsai, CY | 1 |
Chang, DM | 1 |
Jones, N | 1 |
Hizawa, K | 1 |
Nagata, Y | 1 |
Taniguchi, M | 1 |
Nakamori, M | 1 |
Matsumoto, T | 1 |
Iida, M | 1 |
Rubia, MF | 1 |
Chozas, N | 1 |
García-Martos, P | 1 |
Reyes, F | 1 |
Tschudin, S | 1 |
Laifer, G | 1 |
Orasch, C | 1 |
Nüesch, R | 1 |
Baumgart, DC | 1 |
Kassalik, M | 1 |
Fry, LC | 1 |
Didowacz-Grollmann, A | 1 |
Mousalli, S | 1 |
Mönkemüller, K | 1 |
Foster, JD | 1 |
Hartmann, FA | 1 |
Moriello, KA | 1 |
Aringer, M | 1 |
Graninger, WB | 1 |
Steiner, G | 1 |
Smolen, JS | 1 |
Ko, KS | 1 |
Cho, DO | 1 |
Ahn, JH | 1 |
Lee, TW | 1 |
Ihm, CG | 1 |
Chang, SG | 1 |
Chai, SE | 1 |
Park, HC | 1 |
Hong, SH | 1 |
Joo, HZ | 1 |
Klauser, R | 1 |
Zlabinger, GJ | 1 |
Traindl, O | 1 |
Franz, M | 1 |
Watschinger, B | 1 |
Pohanka, E | 1 |
Kudlacek, S | 1 |
Kovarik, J | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Randomized, Double-Blind, Placebo-Controlled, Phase II, Multi-Center Study for Treatment of Lupus Nephritis by Inhibition of Tumor Necrosis Factor-alpha Using Etanercept[NCT00447265] | Phase 2 | 1 participants (Actual) | Interventional | 2008-02-29 | Terminated (stopped due to The perceived risk-benefit ratio for individuals with early active RA) | ||
A Double Blind, Randomized, Placebo Controlled, Multi-Center Trial of Anti-TNF-alpha Chimeric Monoclonal Antibody (Infliximab) and Azathioprine in Patients Suffering From Systemic Lupus Erythematosus (SLE) With WHO Class V Glomerulonephritis[NCT00368264] | Phase 2/Phase 3 | 1 participants (Actual) | Interventional | 2006-09-30 | Terminated (stopped due to Failure to recruit patients with membranous lupus nephritis not previously treated with azathioprine .) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Number of adverse events (AEs) or serious adverse events (SAEs) Grade 3 or higher experienced by participant over the duration of the treatment period. [1]~[1] This study graded the severity of AEs experienced by the study participant according to the criteria set forth in the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 3.0." (NCT00447265)
Timeframe: 24 Weeks
Intervention | Events (Number) |
---|---|
Etanercept | 0 |
Number of participant AEs during the trial. This study graded the severity of AEs experienced by the study participant according to the criteria set forth in the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 3.0. (NCT00447265)
Timeframe: 39 Weeks
Intervention | Events (Number) |
---|---|
Etanercept | 3 |
Reported here is the number of participants with a change in their BILAG Musculoskeletal Score from B (at baseline) to D (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0).A maximum musculoskeletal score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system. (NCT00447265)
Timeframe: Baseline, Week 24
Intervention | Participants (Number) |
---|---|
Etanercept | 1 |
Reported here is the number of participants with a change in their BILAG Mucocutaneous Score from C (at baseline) to B (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0). A maximum mucocutaneous score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system. (NCT00447265)
Timeframe: Baseline, Week 24
Intervention | Participants (Number) |
---|---|
Etanercept | 1 |
Reported here is the number of participants with a change in their BILAG Renal Score from A (at baseline) to B (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0).A maximum renal score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system (NCT00447265)
Timeframe: Baseline, Week 24
Intervention | Participants (Number) |
---|---|
Etanercept | 1 |
"Percent of study participants who achieved a renal response at 24 weeks.[1]~[1]A renal response is defined as: 1) 50% reduction in proteinuria compared to baseline as measured by urinary protein: creatinine ratio; and 2) stable or improving renal function as defined by the Glomerular filtration rate (GFR) calculated based on the Modification of Diet in Renal Disease equation (Levy, AS, Coresh J, Galk E et al, National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med, 139(2): 137-47, 2003)" (NCT00447265)
Timeframe: Week 24
Intervention | Percent of Participants (Number) |
---|---|
Etanercept | 100 |
"Time to when participant achieved a renal response[1]~[1]A renal response is defined as: 1) 50% reduction in proteinuria compared to baseline as measured by urinary protein: creatinine ratio; and 2) stable or improving renal function as defined by the Glomerular filtration rate (GFR) calculated based on the Modification of Diet in Renal Disease equation (Levy, AS, Coresh J, Galk E et al, National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med, 139(2): 137-47, 2003)" (NCT00447265)
Timeframe: First 24 Weeks of Study Period
Intervention | Weeks (Number) |
---|---|
Etanercept | 24 |
"Reported here are the participant SF-36 Mental Component scores at baseline and week 24. The SF-36 measures 8 domains: physical functioning, role limitations due to physical health, bodily pain, social functioning, mental health, role limitations due to emotional problems, vitality, and general health perceptions.[1] The Mental Component score of the SF-36 ranges from 0 to 100; 0 equals worst health state. Higher numbers reported here indicate more improvement in condition from baseline.~[1]Ref: Ware JE, Sherbourne CD. The MOS36-item short-form health survey. Med Care. 1992; 30:473-483" (NCT00447265)
Timeframe: Baseline, Week 24
Intervention | Score on a scale (Number) | |
---|---|---|
Baseline SF-36 Mental Component Score | Week 24 SF-36 Mental Component Score | |
Etanercept | 31.4 | 52.3 |
"Reported here is the participant baseline and week 24 SF-36 Physical Component scores. The SF-36 measures 8 domains: physical functioning, role limitations due to physical health, body pain, social functioning, mental health, role limitations due to emotional problems, vitality, and general health perceptions[1]. The Physical Component scores of the SF-36 range from 0 to 100; 0 equals worst health state. Higher numbers reported here indicate more improvement in condition from baseline.~[1]Ref: Ware JE, Sherbourne CD. The MOS36-item short-form health survey Med Care. 1992; 30:473-483." (NCT00447265)
Timeframe: Baseline, Week 24
Intervention | Score on a scale (Number) | |
---|---|---|
Baseline SF-36 Physical Component Score | Week 24 SF-36 Physical Component Score | |
Etanercept | 44.4 | 42.3 |
Reported here is the baseline and week 39 Systematic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. The SLEDAI is a concise measure of lupus disease activity with excellent test-retest reliability and high responsiveness to clinically important changes in the disease. The total score is derived from ratings on 24 conditions plus the Physician's Global Assessment; 0 indicates inactive disease and the maximum theoretical score is 105, with higher scores representing increased disease activity. (NCT00447265)
Timeframe: Baseline, Week 39 (Early Study Withdrawal Visit)
Intervention | Points on a scale (Number) | |
---|---|---|
Baseline SLEDAI Score | Week 39 SLEDAI score | |
Etanercept | 22 | 8 |
1 trial available for azathioprine and Bacteremia
Article | Year |
---|---|
Influence of immunosuppressive therapy on infectious complications in renal transplant recipients.
Topics: Adult; Antilymphocyte Serum; Azathioprine; Bacteremia; Cyclosporine; Female; Graft Rejection; Humans | 1992 |
10 other studies available for azathioprine and Bacteremia
Article | Year |
---|---|
Invasive aspergillosis in patients with systemic lupus erythematosus: a retrospective study on clinical characteristics and risk factors for mortality.
Topics: Adult; Aspergillosis; Azathioprine; Bacteremia; Cytomegalovirus Infections; Female; Humans; Logistic | 2018 |
Sepsis During Immunosuppression for Sight-threatening Uveitis: The Flip side.
Topics: Adult; Aged; Azathioprine; Bacteremia; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immu | 2018 |
[Bacillus cereus bacteremia in Crohn's disease with multiple ileal stricture on maintenance azathioprine therapy].
Topics: Adult; Azathioprine; Bacillus cereus; Bacteremia; Crohn Disease; Humans; Ileal Diseases; Ileum; Immu | 2009 |
[Mycobacterium neoaurum bacteremia in an immunodepressed patient].
Topics: Adult; Azathioprine; Bacteremia; Colitis, Ulcerative; Female; Humans; Immunocompromised Host; Immuno | 2009 |
[Headaches and aphasia in an immunocompromised patient].
Topics: Aged, 80 and over; Aphasia; Atrophy; Azathioprine; Bacteremia; Brain; Brain Abscess; Colitis, Ulcera | 2009 |
How many lives does an ulcerative colitis patient have?
Topics: Abscess; Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Aortic Valve Insufficiency; Atriove | 2010 |
Listeria monocytogenes sepsis in ulcerative colitis.
Topics: Anti-Bacterial Agents; Azathioprine; Bacteremia; Colitis, Ulcerative; Humans; Immunosuppressive Agen | 2012 |
A case of apparent canine erysipeloid associated with Erysipelothrix rhusiopathiae bacteraemia.
Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Azathioprine; Bacteremia; Dog Diseases; Dogs; Erysipelo | 2012 |
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter | 2004 |
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter | 2004 |
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter | 2004 |
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter | 2004 |
Infections after renal transplantation.
Topics: Adult; Azathioprine; Bacteremia; Bacteria; Cyclosporine; Drug Therapy, Combination; Female; Follow-U | 1994 |