Page last updated: 2024-10-23

azathioprine and Atrophy

azathioprine has been researched along with Atrophy in 30 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed."1.35Hypothermia in VGKC antibody-associated limbic encephalitis. ( Clover, L; Grubneac, A; Irani, SR; Jacob, S; Rajabally, YA; Vincent, A; Walters, RJ; Yazaki, M, 2008)
"We present the case of a patient with Crohn's disease under immunosuppressive therapy who developed a spontaneous covered spleen rupture in the course of a septic shock with DIG due to a Varizella zoster infection."1.32[Functional asplenia after severe varicella zoster-infection diagnosis by colour Doppler ultrasound]. ( Arnold, R; Diedrich, J; Eissele, R; Görg, C, 2003)
"A 26-year-old woman suffered from acute myelitis at Th 6 level associated with systemic lupus erythematosus."1.31Development of severe longitudinal atrophy of thoracic spinal cord following lupus-related myelitis. ( Kawagoe, J; Kawasaki, S; Matsukura, S; Ohi, T; Shiomi, K; Sugimoto, S; Yazawa, S, 2001)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199013 (43.33)18.7374
1990's5 (16.67)18.2507
2000's9 (30.00)29.6817
2010's3 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zivadinov, R5
Bergsland, N5
Dolezal, O5
Hussein, S4
Seidl, Z5
Dwyer, MG5
Vaneckova, M5
Krasensky, J3
Potts, JA1
Kalincik, T1
Havrdová, E5
Horáková, D5
Cox, JL4
Rimes, B1
Novakova, I1
Ticha, V1
Dusek, L1
Houzvickova, E1
Svobodnik, A1
Tschudin, S1
Laifer, G1
Orasch, C1
Nüesch, R1
Kýr, M1
Lelková, P1
Pospíšilová, L1
Zaidan, M1
Lidove, O1
Sacré, K1
Klein, I1
Papo, T1
Diedrich, J1
Görg, C1
Eissele, R1
Arnold, R1
Ziegler, TR1
Fernández-Estívariz, C1
Gu, LH1
Fried, MW1
Leader, LM1
Ganesh, SK1
Narayana, KM1
Biswas, J1
Cookfair, D1
Jacob, S1
Irani, SR1
Rajabally, YA1
Grubneac, A1
Walters, RJ1
Yazaki, M1
Clover, L1
Vincent, A1
Mihály, A1
Pór, I1
Bencze, G1
Csillik, B1
Laine, J1
Krogerus, L1
Jalanko, H1
Rönnholm, K1
Holmberg, C1
Labib, M1
Haddon, A1
Delamere, J1
Lulin, M1
Yantang, L1
Lachaux, A1
Loras-Duclaux, I1
Bouvier, R1
Yazawa, S1
Kawasaki, S1
Ohi, T1
Shiomi, K1
Sugimoto, S1
Kawagoe, J1
Matsukura, S1
Nellans, RE1
Ravera, J1
Zóltowska, A1
Vallet, B1
Fourrier, F1
Hurtevent, JF1
Parent, M1
Chopin, C1
Santelli, G1
Hiesse, C1
Schovaert, D1
Fassi-Fihri, S1
Lantz, O1
Bensadoun, H1
Benoit, G1
Charpentier, B1
Martin, E1
Fries, D1
Madarikan, BA1
White, RH1
Glasgow, EF1
Mills, RJ1
Lingardh, G1
Andersson, L1
Osterman, B1
Convit, J1
Kerdel, F1
Goihman, M1
Rondon, AJ1
Soto, JM1
Eiseman, B1
Macpherson, SG1
Anderson, JM1
Bell, JR1
Miller, SE1
Buxton, BF1
Wood, RF1
Calman, KC1
Bell, PR1
Hillman, HS1
Krueger, GR1
Malmgren, RA1
Berard, CW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Lesion Activity Analysis in the Avonex- Steroid Azathioprine (ASA) Study[NCT01628315]159 participants (Actual)Observational2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for azathioprine and Atrophy

ArticleYear
Evolution of cortical and thalamus atrophy and disability progression in early relapsing-remitting MS during 5 years.
    AJNR. American journal of neuroradiology, 2013, Volume: 34, Issue:10

    Topics: Adjuvants, Immunologic; Adult; Atrophy; Azathioprine; Cerebral Cortex; Disability Evaluation; Diseas

2013
Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study.
    Journal of the neurological sciences, 2009, Jul-15, Volume: 282, Issue:1-2

    Topics: Adult; Atrophy; Azathioprine; Brain; Cerebral Ventricles; Disease Progression; Drug Therapy, Combina

2009
Randomized study of interferon beta-1a, low-dose azathioprine, and low-dose corticosteroids in multiple sclerosis.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2009, Volume: 15, Issue:8

    Topics: Administration, Oral; Adrenal Cortex Hormones; Atrophy; Azathioprine; Brain; Disability Evaluation;

2009
Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: a case-control study.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:4

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Atrophy; Azathioprine; Brain; Cerebral Ventricles; Diseas

2008
Pathology of two-year renal biopsies in cyclosporine and conventionally immunosuppressed renal transplants.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 2

    Topics: Adrenal Cortex Hormones; Atrophy; Azathioprine; Biopsy; Clinical Trials as Topic; Cyclosporins; Drug

1989

Other Studies

25 other studies available for azathioprine and Atrophy

ArticleYear
[Headaches and aphasia in an immunocompromised patient].
    Praxis, 2009, Jul-08, Volume: 98, Issue:14

    Topics: Aged, 80 and over; Aphasia; Atrophy; Azathioprine; Bacteremia; Brain; Brain Abscess; Colitis, Ulcera

2009
Apolipoprotein E ε4-positive multiple sclerosis patients develop more gray-matter and whole-brain atrophy: a 15-year disease history model based on a 4-year longitudinal study.
    Folia biologica, 2010, Volume: 56, Issue:6

    Topics: Adjuvants, Immunologic; Adult; Anti-Inflammatory Agents; Apolipoprotein E4; Atrophy; Azathioprine; B

2010
"Fulminant" Behçet disease.
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11

    Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents; Antibodies, Monoclonal; Atrophy; Azathio

2011
[Functional asplenia after severe varicella zoster-infection diagnosis by colour Doppler ultrasound].
    Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:4

    Topics: Adult; Atrophy; Azathioprine; Crohn Disease; Drug Therapy, Combination; Follow-Up Studies; Herpes Zo

2003
Severe villus atrophy and chronic malabsorption induced by azathioprine.
    Gastroenterology, 2003, Volume: 124, Issue:7

    Topics: Adult; Atrophy; Azathioprine; Carrier Proteins; Chronic Disease; Dipeptidyl Peptidase 4; Duodenum; H

2003
Peripapillary choroidal atrophy in sympathetic ophthalmia and management with triple-agent immunosuppression.
    Ocular immunology and inflammation, 2003, Volume: 11, Issue:1

    Topics: Adult; Atrophy; Azathioprine; Child; Choroid; Choroid Diseases; Cyclosporine; Drug Therapy, Combinat

2003
Hypothermia in VGKC antibody-associated limbic encephalitis.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:2

    Topics: Aged; Atrophy; Autoantibodies; Azathioprine; Cyclosporine; Dominance, Cerebral; Epilepsy, Temporal L

2008
Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon peripheral and central processes of primary nociceptive neurons.
    Zeitschrift fur mikroskopisch-anatomische Forschung, 1980, Volume: 94, Issue:3

    Topics: Action Potentials; Animals; Antineoplastic Agents; Atrophy; Azathioprine; Chelating Agents; Cyclopho

1980
Renal allograft histology and correlation with function in children on triple therapy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1995, Volume: 10, Issue:1

    Topics: Adolescent; Atrophy; Azathioprine; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination;

1995
Behçet's disease and hypopituitarism: a possible link.
    Annals of clinical biochemistry, 1994, Volume: 31 ( Pt 5)

    Topics: Atrophy; Azathioprine; Behcet Syndrome; Biomarkers; Colchicine; Cosyntropin; Follicle Stimulating Ho

1994
Comparison of the immunosuppressive and toxic effects of TII and azathioprine.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Animals; Atrophy; Azathioprine; Body Weight; China; Drugs, Chinese Herbal; Female; Graft Survival; H

1998
Autoimmune enteropathy in infants. Pathological study of the disease in two familial cases.
    Virchows Archiv : an international journal of pathology, 1998, Volume: 433, Issue:5

    Topics: Anti-Inflammatory Agents; Atrophy; Autoimmune Diseases; Azathioprine; Cyclosporine; Diarrhea, Infant

1998
Development of severe longitudinal atrophy of thoracic spinal cord following lupus-related myelitis.
    Internal medicine (Tokyo, Japan), 2001, Volume: 40, Issue:4

    Topics: Adult; Atrophy; Azathioprine; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Lupus Ery

2001
Seminoma in a renal transplant recipient.
    The Journal of urology, 1975, Volume: 113, Issue:6

    Topics: Adult; Atrophy; Azathioprine; Cobalt Radioisotopes; Dysgerminoma; Humans; Inguinal Canal; Kidney Dis

1975
Lymphoreticular tissue lesions in mice after immunization with typhoid fever vaccine and immunosuppression with azathioprine.
    Beitrage zur Pathologie, 1975, Volume: 156, Issue:3

    Topics: Animals; Atrophy; Azathioprine; Female; Hyperplasia; Immunization Schedule; Immunosuppression Therap

1975
Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
    Intensive care medicine, 1992, Volume: 18, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Atrophy; Azathioprine; Electromyography; Female; Humans; Lung Volume

1992
Testicular salvage following spermatic cord torsion.
    Journal of pediatric surgery, 1987, Volume: 22, Issue:3

    Topics: Animals; Atrophy; Azathioprine; Cyclosporins; Hydrocortisone; Male; Orchiectomy; Organ Size; Rats; R

1987
Renal histopathology in kidney transplant recipients immunosuppressed with cyclosporin A: results of an international workshop.
    Clinical nephrology, 1985, Volume: 24, Issue:3

    Topics: Arterioles; Atrophy; Azathioprine; Biopsy; Cyclosporins; Graft Rejection; Humans; Immunosuppression

1985
Focal glomerulosclerosis in childhood.
    Perspectives in nephrology and hypertension, 1973, Volume: 1 Pt 1

    Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Atrophy; Azathioprine; Basement Membrane; Biopsy;

1973
Fertility in men after renal transplantation.
    Acta chirurgica Scandinavica, 1974, Volume: 140, Issue:6

    Topics: Adult; Atrophy; Azathioprine; Cushing Syndrome; Depression, Chemical; Erectile Dysfunction; Female;

1974
Progressive, atrophying, chronic granulomatous dermohypodermitis. Autoimmune disease?
    Archives of dermatology, 1973, Volume: 107, Issue:2

    Topics: Adult; Atrophy; Autoimmune Diseases; Axilla; Azathioprine; BCG Vaccine; Chronic Disease; Cutis Laxa;

1973
Liver transplantation.
    Studium generale; Zeitschrift fur die Einheit der Wissenschaften im Zusammenhang ihrer Begriffsbildungen und Forschungsmethoden, 1970, Volume: 23, Issue:4

    Topics: Antilymphocyte Serum; Atrophy; Azathioprine; Biliary Tract; Congenital Abnormalities; Histocompatibi

1970
The effect of liver damage and immunosuppression on canine auxiliary iiver transplantation.
    The British journal of surgery, 1970, Volume: 57, Issue:11

    Topics: Animals; Atrophy; Azathioprine; Bilirubin; Dactinomycin; Liver; Liver Transplantation; Methylprednis

1970
Intestinal malabsorption with subtotal villous atrophy unresponsive to a gluten-free diet but responding to immunosuppressive therapy.
    The Medical journal of Australia, 1972, Jul-08, Volume: 2, Issue:2

    Topics: Adult; Atrophy; Azathioprine; Biopsy; Diet Therapy; Drug Hypersensitivity; Glutens; Humans; Intestin

1972
Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation.
    Transplantation, 1971, Volume: 11, Issue:2

    Topics: Animals; Antigens; Antilymphocyte Serum; Atrophy; Azathioprine; Female; Freund's Adjuvant; Glomerulo

1971