azathioprine and Asthma studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

Excerpt	Relevance	Reference
" This study was undertaken to determine whether the addition of azathioprine (AZA) to glucocorticoids could achieve a higher sustained remission rate of newly diagnosed nonsevere eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA), microscopic polyangiitis (MPA), or polyarteritis nodosa (PAN)."	9.24	Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial. ( Agard, C; Baron, G; Bienvenu, B; Bourgarit, A; Cohen, P; Crestani, B; Delbrel, X; Diot, E; Geffray, L; Godmer, P; Groh, M; Guillevin, L; Le Guern, V; Le Jeunne, C; Lifermann, F; Limal, N; Liozon, E; Mékinian, A; Mouthon, L; Néel, A; Pagnoux, C; Papo, T; Puéchal, X; Quémeneur, T; Ravaud, P; Ruivard, M; Ruppert, AM; Sailler, L; Saraux, JL; Terrier, B, 2017)
"The objective of this review is to assess the efficacy of adding azathioprine in patients with stable asthma who are dependent on oral corticosteroids with the intention of eventually minimizing or eliminating the use of these steroids."	8.82	Azathioprine as an oral corticosteroid sparing agent for asthma. ( Bara, A; Dean, T; Dewey, A; Lasserson, TJ; Walters, EH, 2004)
" This study was undertaken to determine whether the addition of azathioprine (AZA) to glucocorticoids could achieve a higher sustained remission rate of newly diagnosed nonsevere eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA), microscopic polyangiitis (MPA), or polyarteritis nodosa (PAN)."	5.24	Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial. ( Agard, C; Baron, G; Bienvenu, B; Bourgarit, A; Cohen, P; Crestani, B; Delbrel, X; Diot, E; Geffray, L; Godmer, P; Groh, M; Guillevin, L; Le Guern, V; Le Jeunne, C; Lifermann, F; Limal, N; Liozon, E; Mékinian, A; Mouthon, L; Néel, A; Pagnoux, C; Papo, T; Puéchal, X; Quémeneur, T; Ravaud, P; Ruivard, M; Ruppert, AM; Sailler, L; Saraux, JL; Terrier, B, 2017)
"The objective of this review is to assess the efficacy of adding azathioprine in patients with stable asthma who are dependent on oral corticosteroids with the intention of eventually minimizing or eliminating the use of these steroids."	4.82	Azathioprine as an oral corticosteroid sparing agent for asthma. ( Bara, A; Dean, T; Dewey, A; Lasserson, TJ; Walters, EH, 2004)
"A series of 191 patients with bronchial asthma were treated with menaquinone for not less than one year to investigate the clinical effects of the drug."	2.64	Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma. ( Kimur, I; Saito, K; Sato, S; Takahashi, K; Tanizaki, Y, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (62.50)	18.7374
1990's	4 (8.33)	18.2507
2000's	5 (10.42)	29.6817
2010's	8 (16.67)	24.3611
2020's	1 (2.08)	2.80

Authors	Studies
McWhirter, S	1
Robinson, P	1
Orchard, D	1
Puéchal, X	2
Pagnoux, C	3
Baron, G	2
Quémeneur, T	2
Néel, A	2
Agard, C	2
Lifermann, F	2
Liozon, E	1
Ruivard, M	2
Godmer, P	1
Limal, N	2
Mékinian, A	1
Papo, T	1
Ruppert, AM	1
Bourgarit, A	1
Bienvenu, B	1
Geffray, L	2
Saraux, JL	2
Diot, E	1
Crestani, B	1
Delbrel, X	1
Sailler, L	1
Cohen, P	2
Le Guern, V	1
Terrier, B	2
Groh, M	1
Le Jeunne, C	2
Mouthon, L	2
Ravaud, P	2
Guillevin, L	3
Wislez, M	1
Cottin, V	1
Aouba, A	1
Bonnotte, B	1
Leu, T	1
Rauthe, S	1
Wirth, C	1
Simon, HU	1
Kunzmann, V	1
Hebestreit, H	1
Kunzmann, S	1
Adema, AY	1
Schilder, AM	1
Schreuder, TC	1
Grünberg, K	1
Bultink, IE	1
Mulder, CJ	1
Bush, A	1
Saglani, S	1
Dunogué, B	1
Gonzales, M	1
Fratianni, C	1
Mamillapali, C	1
Khardori, R	1
Watanabe, H	1
Uruma, T	1
Tsunoda, T	1
Ishii, H	1
Tazaki, G	1
Kondo, T	1
COHEN, EP	1
PETTY, TL	1
SZENTIVANYI, A	1
PRIEST, RE	1
Dean, T	1
Dewey, A	1
Bara, A	1
Lasserson, TJ	1
Walters, EH	1
Dixit, RK	1
Bargagli, E	1
Madioni, C	1
Olivieri, C	1
Penza, F	1
Rottoli, P	1
Wishnick, MM	1
Valensi, Q	1
Doyle, EF	1
Balian, A	1
Genieser, NB	1
Chrousos, G	1
Latysh, VN	1
Rozhok, EI	1
Cormio, G	1
Cramarossa, D	1
Di Vagno, G	1
Masciandaro, A	1
Loverro, G	1
Kuo, E	1
Kesten, S	1
Saadeh, C	1
Urban, RS	1
Söhngen, D	1
Specker, C	1
Bach, D	1
Kuntz, BM	1
Burk, M	1
Aul, C	1
Kobbe, G	1
Heyll, A	1
Hollmig, KA	1
Schneider, W	1
Solans, R	1
Bosch, JA	1
Pérez-Bocanegra, C	1
Selva, A	1
Huguet, P	1
Alijotas, J	1
Orriols, R	1
Armadans, L	1
Vilardell, M	1
Vemuri, P	1
Greenberger, PA	1
Patterson, R	2
Chumbley, LC	1
Harrison, EG	1
DeRemee, RA	1
Kimur, I	1
Tanizaki, Y	1
Sato, S	1
Saito, K	1
Takahashi, K	1
Viazitskiĭ, PO	1
Tokarev, NF	1
Serikova, AZ	1
Ivanov, SL	1
Shurygin, DIa	1
Volchek, IuZ	1
Grozovskiĭ, IuR	1
Engelhardt, A	1
Thron, C	1
Glötzner, FL	1
Neundörfer, B	1
Clutterbuck, EJ	1
Pusey, CD	1
Lovisetto, P	1
Manachino, D	1
Biarese, V	1
Marchi, L	1
Andrione, P	1
Rudyk, BI	1
Filipp, G	1
Eisner, JW	1
Irons, JS	1
Kelly, JF	1
Mattson, JR	1
O, SH	1
Lorenzen, I	2
Videbaek, A	2
Brun, C	1
Formgren, H	1
Rosman, M	1
Bertino, JR	1
Sharma, OP	1
Szulczyńska, K	1
Hodges, NG	1
Brewis, RA	1
Howell, JB	1
Campanacci, L	1
Khanina, SB	1
Chudinovskikh, AIa	1
Kulenko, EM	1
Guglielmi, G	1
Palermo, M	1
Mancinella, A	1
Lee, AK	1
Mackay, IR	1
Rowley, MJ	1
Yap, CY	1
Nicolaescu, V	2
Drăgulescu, I	2
Racoveanu, C	2
Berceanu, S	1
Wiontzek, H	1
Adler, E	1
Raiciulescu, N	1
Kaiser, HB	1
Beall, GN	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Evaluation of a New Treatment Strategy for Patients With Microscopic Polyangiitis, Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Without Poor Prognosis Factors[NCT00647166]			Phase 3	114 participants (Actual)	Interventional	2008-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Management of severe asthma in children. Lancet (London, England), 2010, Sep-04, Volume: 376, Issue:9743 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Allergens; Anti-Asthmatic Agents; Asthma; Azath	2010
Immunotherapy in miscellaneous medical disorders Graves ophthalmopathy, asthma, and regional painful syndrome. The Medical clinics of North America, 2012, Volume: 96, Issue:3 Topics: Allergens; Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Ant	2012
Azathioprine as an oral corticosteroid sparing agent for asthma. The Cochrane database of systematic reviews, 2004, Issue:1 Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Anti-Asthmatic Agents; As	2004
[Blood hypereosinophilias. IV. Symptomatic hypereosinophilias: connective tissue diseases, neoplasms, blood diseases, various causes]. Minerva medica, 1985, Jun-16, Volume: 76, Issue:25 Topics: Aged; Asthma; Azathioprine; Connective Tissue Diseases; Cortisone; Eosinophilia; Female; Hematologic	1985
Drugs used in allergic states and their mode of action. Seminars in drug treatment, 1973,Spring, Volume: 2, Issue:4 Topics: Anti-Inflammatory Agents; Asthma; Azathioprine; Catecholamines; Cromolyn Sodium; Drug-Related Side E	1973

Article	Year
Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors: A Randomized, Controlled Trial. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:11 Topics: Adult; Aged; Asthma; Azathioprine; Churg-Strauss Syndrome; Disease Progression; Double-Blind Method;	2017
Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma. Acta medica Okayama, 1975, Volume: 29, Issue:2 Topics: Asthma; Azathioprine; Clinical Trials as Topic; Desensitization, Immunologic; Drug Combinations; gam	1975
An evaluation of azathioprine in severe chronic asthma. Thorax, 1971, Volume: 26, Issue:6 Topics: Adult; Aged; Asthma; Azathioprine; Chronic Disease; Clinical Trials as Topic; Female; Humans; Leukoc	1971

azathioprine and Asthma

Research Excerpts

Research

Studies (48)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Asthma improvement in children with eczema treated with azathioprine: A case series. The Australasian journal of dermatology, 2021, Volume: 62, Issue:2 Topics: Adolescent; Asthma; Azathioprine; Child; Comorbidity; Eczema; Female; Humans; Immunosuppressive Agen	2021
Non-severe eosinophilic granulomatosis with polyangiitis: long-term outcomes after remission-induction trial. Rheumatology (Oxford, England), 2019, 12-01, Volume: 58, Issue:12 Topics: Adult; Aged; Asthma; Azathioprine; Churg-Strauss Syndrome; Disease Progression; Disease-Free Surviva	2019
[The Lymphoid Variant of HES (L-HES) as Differential Diagnose of Severe Asthma in Childhood]. Klinische Padiatrie, 2016, Volume: 228, Issue:6-07 Topics: Adolescent; Asthma; Azathioprine; Biopsy, Needle; Bone Marrow; Bronchi; Diagnosis, Differential; Flo	2016
Ascites as the presenting symptom in a patient with Churg-Strauss syndrome. Journal of gastrointestinal and liver diseases : JGLD, 2010, Volume: 19, Issue:2 Topics: Aged; Ascites; Asthma; Azathioprine; Biopsy; Churg-Strauss Syndrome; Drug Therapy, Combination; Dysp	2010
Churg-strauss syndrome: clinical symptoms, complementary investigations, prognosis and outcome, and treatment. Seminars in respiratory and critical care medicine, 2011, Volume: 32, Issue:3 Topics: Adrenal Cortex Hormones; Asthma; Azathioprine; Churg-Strauss Syndrome; Cyclophosphamide; Diagnosis,	2011
Bronchial asthma developing after 15 years of immunosuppressive treatment following renal transplantation. Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:21 Topics: Adult; Asthma; Azathioprine; Cyclosporine; Female; Glomerulonephritis, IGA; Humans; Immunosuppressiv	2012
CLINICAL AND PATHOLOGICAL OBSERVATIONS IN FATAL BRONCHIAL ASTHMA: REPORT OF A CASE TREATED WITH THE IMMUNOSUPPRESSIVE DRUG, AZATHIOPRINE. Annals of internal medicine, 1965, Volume: 62 Topics: Antineoplastic Agents; Asthma; Autonomic Nervous System Diseases; Azathioprine; Bronchodilator Agent	1965
Case 28-2005: a case of systemic necrotizing vasculitis. The New England journal of medicine, 2005, Dec-08, Volume: 353, Issue:23 Topics: Adult; Asthma; Azathioprine; Churg-Strauss Syndrome; Cyclophosphamide; Drug Administration Schedule;	2005
Churg-Strauss vasculitis in a patient treated with omalizumab. The Journal of asthma : official journal of the Association for the Care of Asthma, 2008, Volume: 45, Issue:2 Topics: Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, H	2008
Churg-Strauss syndrome. Development of cardiomyopathy during corticosteroid treatment. American journal of diseases of children (1960), 1982, Volume: 136, Issue:4 Topics: Adolescent; Asthma; Azathioprine; Cardiomyopathies; Cyclophosphamide; Granuloma; Heart Diseases; Hum	1982
[Importance of determining histamine and the histaminopexic index in bronchial asthma during imuran therapy]. Voenno-meditsinskii zhurnal, 1981, Issue:2 Topics: Adult; Asthma; Azathioprine; Female; Histamine; Humans; Immunosuppressive Agents; Male; Middle Aged;	1981
Successful pregnancy in a patient with Churg-Strauss syndrome. European journal of obstetrics, gynecology, and reproductive biology, 1995, Volume: 60, Issue:1 Topics: Adult; Asthma; Azathioprine; Churg-Strauss Syndrome; Female; Humans; Male; Prednisone; Pregnancy; Pr	1995
A retrospective comparative study of in-hospital management of acute severe asthma: 1984 vs 1989. Chest, 1993, Volume: 103, Issue:6 Topics: Acute Disease; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over;	1993
Azathioprine in the treatment of chronic refractory steroid-dependent asthma. Southern medical journal, 1993, Volume: 86, Issue:1 Topics: Adult; Asthma; Azathioprine; Chronic Disease; Humans; Male; Prednisone; Substance-Related Disorders	1993
Acquired factor VIII inhibitors in nonhemophilic patients. Annals of hematology, 1997, Volume: 74, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antibodies; Asthma; Azathioprine; Cytomegalovirus Infections; Factor	1997
Churg-Strauss syndrome: outcome and long-term follow-up of 32 patients. Rheumatology (Oxford, England), 2001, Volume: 40, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Azathioprine; Churg-Strauss Syndrome; Cyclophosp	2001
Churg-Strauss syndrome: survival for 26 years. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:6 Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Asthma; Azathioprine; Churg-Strauss Syndrome; Fatal	2002
Allergic granulomatosis and angiitis (Churg-Strauss syndrome). Report and analysis of 30 cases. Mayo Clinic proceedings, 1977, Volume: 52, Issue:8 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arteritis; Asthma; Azathioprine; Cyclophosphamide;	1977
[Clinico-laboratory indices in bronchial asthma patients treated with imuran]. Terapevticheskii arkhiv, 1977, Volume: 49, Issue:3 Topics: Asthma; Azathioprine; Humans; Middle Aged	1977
[Experience with the use of imuran in some chronic lung disease]. Voenno-meditsinskii zhurnal, 1976, Issue:7 Topics: Adult; Asthma; Azathioprine; Bronchial Spasm; Chronic Disease; Female; Humans; Lung Diseases; Male;	1976
[Polyneuropathy in Churg-Strauss syndrome]. Deutsche medizinische Wochenschrift (1946), 1989, Jun-09, Volume: 114, Issue:23 Topics: Aged; Asthma; Azathioprine; Biopsy; Blood Sedimentation; Chronic Disease; Churg-Strauss Syndrome; Dr	1989
Severe alveolar haemorrhage in Churg-Strauss syndrome. European journal of respiratory diseases, 1987, Volume: 71, Issue:3 Topics: Adult; Asthma; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Hemorrhage; Humans; Lung Dis	1987
[Comparative evaluation of various methods of immunosuppressive therapy in severe bronchial asthma]. Terapevticheskii arkhiv, 1985, Volume: 57, Issue:5 Topics: Adolescent; Adult; Aged; Aminocaproic Acid; Asthma; Autoimmune Diseases; Azathioprine; Chloroquine;	1985
Is specific desensitization due to specific blocking antibodies or due to an immunological tolerance? New experiments on this problem. The Journal of asthma research, 1972, Volume: 9, Issue:3 Topics: Adrenal Cortex Hormones; Animals; Antibodies; Antibody Formation; Antigen-Antibody Complex; Antigens	1972
Pulmonary infiltrates with eosinophilia. The Journal of allergy and clinical immunology, 1974, Volume: 53, Issue:4 Topics: Aspergillosis; Asthma; Azathioprine; Eosinophilia; Eosinophils; Humans; Leukemia, Myeloid; Lung Dise	1974
Treatment of collagen diseases with cytostatics. Lancet (London, England), 1965, Sep-18, Volume: 2, Issue:7412 Topics: Adrenal Cortex Hormones; Adult; Aged; Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Asthma;	1965
Treatment of immunologic diseases with cytostatics. Acta medica Scandinavica, 1969, Volume: 185, Issue:6 Topics: Anemia; Anemia, Hemolytic, Autoimmune; Asthma; Autoimmune Diseases; Azathioprine; Dyspepsia; gamma-G	1969
Immunosuppressive treatment of bronchial asthma. Allergie und Asthma, 1970, Volume: 16, Issue:1 Topics: Adrenocorticotropic Hormone; Aged; Asthma; Azathioprine; Blood Platelets; Bronchial Diseases; Eosino	1970
Steroid drugs in chest disease. British medical journal, 1972, May-20, Volume: 2, Issue:5811 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Azathioprine; Humans; Hydrocortisone;	1972
Azathioprine. Annals of internal medicine, 1973, Volume: 79, Issue:5 Topics: Arthritis, Rheumatoid; Asthma; Autoimmune Diseases; Azathioprine; Colitis, Ulcerative; Glomeruloneph	1973
Drug-induced pulmonary disease. Annals of internal medicine, 1973, Volume: 78, Issue:4 Topics: Adult; Asthma; Azathioprine; Colitis, Ulcerative; Cromolyn Sodium; Female; Humans; Lung; Lung Diseas	1973
[Use of immunosuppressive drugs in bronchial asthma (author's transl)]. Przeglad lekarski, 1973, Volume: 30, Issue:7 Topics: Adrenal Cortex Hormones; Adult; Anemia, Aplastic; Asthma; Azathioprine; Female; Humans; Male; Middle	1973
[Disodium cromoglycate in therapy of bronchial asthma. The Goodpasture syndrome]. Giornale di clinica medica, 1971, Volume: 52, Issue:1 Topics: Adult; Anti-Glomerular Basement Membrane Disease; Asthma; Azathioprine; Chromones; Cromolyn Sodium;	1971
[Immunodepressive therapy in bronchial asthma]. Terapevticheskii arkhiv, 1971, Volume: 43, Issue:5 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Azathioprine; Cyclophosphamide; Female; Humans;	1971
[New therapeutic trends in bronchial asthma: the use of azathioprine (clinical results in 3 cases)]. La Clinica terapeutica, 1971, Mar-31, Volume: 56, Issue:6 Topics: Adult; Asthma; Azathioprine; Female; Humans; Male; Middle Aged	1971
Measurement of antibody-producing capacity to flagellin in man. IV. Studies in autoimmune disease, allergy and after azathioprine treatment. Clinical and experimental immunology, 1971, Volume: 9, Issue:4 Topics: Animals; Antibody Formation; Antigens, Bacterial; Arthritis, Rheumatoid; Asthma; Autoimmune Diseases	1971
[Immunosuppressive treatment of bronchial asthma]. Studii si cercetari de medicina interna, 1969, Volume: 10, Issue:3 Topics: Adult; Anti-Bacterial Agents; Asthma; Azathioprine; Cortisone; Female; Humans; Immunosuppressive Age	1969
[Panmyelopathy after viral hepatitis. Comment to H. Wallnöfer, K. Tauber: Med. Klin. 65 (1970), 159]. Medizinische Klinik, 1970, Oct-16, Volume: 65, Issue:42 Topics: Aminopyrine; Asthma; Azathioprine; Bone Marrow Diseases; Chloramphenicol; Female; Hepatitis A; Human	1970
[Treatment of severe bronchial asthma with azathioprine]. Allergie und Asthma, 1970, Volume: 16, Issue:6 Topics: Adult; Asthma; Azathioprine; Chronic Disease; Cortisone; Eosinophils; Female; Humans; Male; Middle A	1970
Azathioprine (imuran) in chronic asthma. Annals of allergy, 1966, Volume: 24, Issue:7 Topics: Asthma; Azathioprine; Humans	1966