Page last updated: 2024-10-23

azathioprine and Arthritis

azathioprine has been researched along with Arthritis in 74 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Arthritis: Acute or chronic inflammation of JOINTS.

Research Excerpts

ExcerptRelevanceReference
"Severe pancytopenia due to azathioprine (AZA) toxicity in patients with autoimmune diseases is not uncommon."7.69Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. ( Haas, JP; Leipold, G; Oellerich, M; Schütz, E, 1997)
"Leflunomide is a new immunosuppressive drug recently introduced in the treatment of rheumatoid and psoriatic arthritis."5.33Anti-Jo-1 antibody positive polymyositis--successful therapy with leflunomide. ( Lange, U; Müller-Ladner, U; Piegsa, M; Strunk, J, 2006)
" Renewed remission was obtained with additional infliximab, and was maintained with azathioprine for 12 months before the patient again presented with symmetrical polyarthritis."3.73[Symmetric polyarthritis in a patient with Churg-Strauss syndrome]. ( Aries, PM; Reinhold-Keller, E, 2005)
"In an open-label study, 6 patients with moderately active SLE (4 with nephritis and 3 with arthritis refractory to other therapies) were given 4 300-mg doses of infliximab, a chimeric anti-TNFalpha antibody, in addition to immunosuppression with azathioprine or methotrexate."3.72Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study. ( Aringer, M; Graninger, WB; Smolen, JS; Steiner, G, 2004)
"We present a 28-year-old patient with liquefying idiopathic lobular panniculitis, a variant of the Weber-Christian's disease and intermittent episodes of arthritis in the left foot refractory to sequential treatment with anti-inflammatory drugs, high doses of prednisone, chloroquine, dapsone, colchicine, cyclosporine and methotrexate."3.69[Refractory idiopathic liquefying panniculitis]. ( Antón Badiola, I; Ferreiro Seoane, JL; Formigo Rodríguez, E; Gómez Rodríguez, N, 1995)
"Severe pancytopenia due to azathioprine (AZA) toxicity in patients with autoimmune diseases is not uncommon."3.69Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. ( Haas, JP; Leipold, G; Oellerich, M; Schütz, E, 1997)
"Arthritis in systemic lupus erythematosus (SLE) is episodic and self-limited in most patients."2.48How to treat refractory arthritis in lupus? ( Artifoni, M; Puéchal, X, 2012)
"Crohn's disease is a perplexing disease with a high rate of morbidity and complications."2.35The protean manifestations of Crohn's disease. ( Farmer, RG, 1975)
"It is important to distinguish between ulcerative colitis and Crohn's colitis because response to treatment and prognosis are different."2.35Inflammatory disease of the colon: ulcerative colitis and Crohn's colitis. ( Ament, ME, 1975)
"As sarcoidosis is a mimicking disease, a good differential diagnosis should be made to avoid misdiagnosis and in order not to be late in diagnosis and treatment."1.72Perspective of sarcoidosis in terms of rheumatology: a single-center rheumatology clinic experience. ( Duruöz, MT; Esen, İ; Gezer, HH; Karabulut, Y; Öz, N, 2022)
"Idiopathic granulomatous mastitis is an inflammatory mass in the breast."1.37A case of granulomatous mastitis with erythema nodosum and arthritis. ( Karimifar, M; Mahzouni, P; Salesi, M; Salimi, F, 2011)
"A 36-year-old woman with systemic lupus erythematosus was admitted to our hospital with malaise, myalgia, dysphagia, fever, preserved muscle strength, leukocytosis (15,600 cells), and increased creatine kinase of 1,358 IU/L that reached 75,000 IU/L in few days."1.37Fatal rhabdomyolysis in systemic lupus erythematosus. ( Bonfa, E; da Mota, LM; de Carvalho, JF, 2011)
"CINCA syndrome is a genetic disorder characterized by early onset of recurrent fever, rash, progressive articular and neurological involvement."1.34CINCA Syndrome. ( Khemani, C; Khubchandani, R, 2007)
"Leflunomide is a new immunosuppressive drug recently introduced in the treatment of rheumatoid and psoriatic arthritis."1.33Anti-Jo-1 antibody positive polymyositis--successful therapy with leflunomide. ( Lange, U; Müller-Ladner, U; Piegsa, M; Strunk, J, 2006)
"A 52-year-old woman with a history of chronic obstructive pulmonary disease presented with symmetrical polyarthritis involving her metacarpophalangeal and proximal interphalangeal joints, knees, ankles, and hips and with a purpuric rash involving her lower extremities."1.32Churg-Strauss syndrome: diagnostic difficulties and pathogenesis. ( Buscemi, DM; Diri, E; Nugent, KM, 2003)
" During gradual reduction of the steroid dosage osteocalcin returned to pretreatment values."1.27Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs. ( Ekenstam, EA; Hällgren, R; Ljunghall, S, 1986)
"The influence of adjuvant arthritis in rats on main urinary metabolites (MUM) of prostaglandin (PG) F and E type was studied."1.26Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E in rats. ( Fukawa, K; Honda, H; Sawabe, T, 1980)
"Of these dogs, 29 had systemic lupus erythematosus, 15 had arthritis in association with some chronic infectious disease process, and 19 had a similar type of arthritis, but without serologic evidence of systemic lupus erythematosus or any chronic infectious disease process."1.26Noninfectious canine arthritis: the inflammatory, nonerosive arthritides. ( Castles, JJ; Ling, GV; Pedersen, NC; Weiser, G; Weisner, K, 1976)
"A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat."1.26Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response. ( Chang, YH, 1977)
"Treatment with azathioprine resulted in a progressive improvement in her condition."1.26A case of pulmonary veno-occlusive disease respondong to treatment with azathioprine. ( Hendry, AT; Sanderson, JE; Spiro, SG; Turner-Warwick, M, 1977)

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-199047 (63.51)18.7374
1990's5 (6.76)18.2507
2000's11 (14.86)29.6817
2010's9 (12.16)24.3611
2020's2 (2.70)2.80

Authors

AuthorsStudies
Lanis, A1
Volochayev, R1
Kleiner, DE1
Vittal, A1
Heller, T1
Rider, LG1
Shenoi, S1
Karabulut, Y1
Öz, N1
Gezer, HH1
Esen, İ1
Duruöz, MT1
Parlow, B1
Mohiuddin, A1
Chou, T1
Cato-Varlack, J1
Boneparth, A1
Moorthy, LN1
Bowling, MR1
Cauthen, CG1
Perry, CD1
Patel, NP1
Bergman, S1
Link, KM1
Sane, AC1
Conforti, JF1
Sahin, G1
Korkmaz, C2
Işiksoy, S1
Yalçin, AU1
Telles, RW1
Ferreira, GA1
da Silva, NP1
Sato, EI1
Salesi, M1
Karimifar, M1
Salimi, F1
Mahzouni, P1
Donghi, D1
Mainetti, C1
Gelber, AC1
Jackson, TE1
Pathak, S1
Doran, RM1
de Carvalho, JF1
da Mota, LM1
Bonfa, E1
Artifoni, M1
Puéchal, X1
Diri, E1
Buscemi, DM1
Nugent, KM1
Aringer, M1
Graninger, WB1
Steiner, G1
Smolen, JS1
Aries, PM1
Reinhold-Keller, E1
Demirtaş-Ertan, G1
Rowshani, AT1
ten Berge, IJ1
Lange, U1
Piegsa, M1
Müller-Ladner, U1
Strunk, J1
Gündüz, E1
Kaşifoğlu, T1
Gülbaş, Z1
Khemani, C1
Khubchandani, R1
Lloyd, A1
Kemball, M1
Fraser, G1
Guillen, C1
Fortea, JM1
Serrano, G1
Martorell, MA1
Cogollos, E1
Alegre, V1
Aliaga, A1
Huskisson, EC1
Sibiriak, SV1
Lazareva, DN1
Kokhanchikova, NA1
Davies, PG1
Fordham, JN1
Jones, JV1
Robinson, MF1
Parciany, RK1
Layfer, LF1
McLeod, B1
Honda, H1
Fukawa, K1
Sawabe, T1
Pillans, PI1
Tooke, AF1
Bateman, ED1
Ainslie, GM1
Gómez Rodríguez, N1
Formigo Rodríguez, E1
Ferreiro Seoane, JL1
Antón Badiola, I1
Felchle, LM1
McPhee, LA1
Kerr, ME1
Houston, DM1
Leipold, G1
Schütz, E1
Haas, JP1
Oellerich, M1
Burmester, GR1
Feist, E1
Krause, A1
Elston, DM1
Cacoub, P1
Sbaï, A1
Toan, SV1
Bellanger, J1
Hoang, C1
Godeau, P1
Piette, JC1
Russo, RA1
Katsicas, MM1
Pedersen, NC1
Weisner, K1
Castles, JJ1
Ling, GV1
Weiser, G1
Thumb, N1
Grabner, H1
Gruber, F1
Kolarz, G1
Kasper, H1
Farmer, RG1
Ament, ME1
Vinegar, R1
Truax, JF1
Selph, JL1
Lea, A1
Johnston, PR1
Chang, YH1
Sanderson, JE1
Spiro, SG1
Hendry, AT1
Turner-Warwick, M1
Feldges, DH2
Barnes, CG2
Prat, A1
Gascon, J1
Shorter, RG1
Shephard, DA1
Clements, PJ1
Davis, J1
Crossley, MJ1
Spowage, M1
Hunneyball, IM1
Ekenstam, EA1
Ljunghall, S1
Hällgren, R2
Kanezuka, T1
Hatanaka, Y1
Pavelka, K1
Alusík, S1
Lukás, K1
Lukás, M1
Mirejovský, P1
Zloský, P1
Brückle, W1
Cochrane, D1
Adamson, AR1
Halsey, JP1
Svenson, K1
Johansson, E1
Lindh, U1
Rhodes, J1
Bainton, D1
Beck, P1
Campbell, H1
Fügner, A1
Levy, L1
Swannell, AJ1
Coomes, EN1
Villard, G1
Delacretaz, J1
Tsukada, W1
Akimoto, T1
Mizushima, Y1
Fidler, JP1
Alexander, JW1
Smith, EJ1
Miller, HC1
Muthiah, V1
Levy, J1
Barnett, EV1
MacDonald, NS1
Klinenberg, JR1
Pearson, CM1
Jouanneau, M1
Brouilhet, H1
Kahan, A1
Charles, A1
Delbarre, F1
Hershfield, NB1
Suzuki, Y1
Ito, I1
Ito, M1
Yamagami, I1
Rothermich, NO1
Arinoviche, R1
Loewi, G1
Grob, PJ1
Arrigoni-Martelli, E1
Schiatti, P1
Selva, D1
Heidelmann, G1
Fleischer, J1
Schwenke, R1
Currey, HL1
Klein, G1
Becke, RF1
Miehlke, K1
Kohlhardt, J1
Wirth, B1
Kafarnik, U1
Gross, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-Blind, Placebo-Controlled, Phase II, Multi-Center Study for Treatment of Lupus Nephritis by Inhibition of Tumor Necrosis Factor-alpha Using Etanercept[NCT00447265]Phase 21 participants (Actual)Interventional2008-02-29Terminated (stopped due to The perceived risk-benefit ratio for individuals with early active RA)
A Double Blind, Randomized, Placebo Controlled, Multi-Center Trial of Anti-TNF-alpha Chimeric Monoclonal Antibody (Infliximab) and Azathioprine in Patients Suffering From Systemic Lupus Erythematosus (SLE) With WHO Class V Glomerulonephritis[NCT00368264]Phase 2/Phase 31 participants (Actual)Interventional2006-09-30Terminated (stopped due to Failure to recruit patients with membranous lupus nephritis not previously treated with azathioprine .)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Adverse Events (AEs)Grade 3 or Higher Experienced by Participant During Treatment Phase of Study

"Number of adverse events (AEs) or serious adverse events (SAEs) Grade 3 or higher experienced by participant over the duration of the treatment period. [1]~[1] This study graded the severity of AEs experienced by the study participant according to the criteria set forth in the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 3.0." (NCT00447265)
Timeframe: 24 Weeks

InterventionEvents (Number)
Etanercept0

Number of Participant Adverse Events (AEs) From Baseline to Early Study Withdrawal Visit

Number of participant AEs during the trial. This study graded the severity of AEs experienced by the study participant according to the criteria set forth in the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 3.0. (NCT00447265)
Timeframe: 39 Weeks

InterventionEvents (Number)
Etanercept3

Number of Participants With a B to D Change From Baseline to Week 24 in the British Isles Lupus Assessment Group (BILAG) Musculoskeletal Score

Reported here is the number of participants with a change in their BILAG Musculoskeletal Score from B (at baseline) to D (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0).A maximum musculoskeletal score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system. (NCT00447265)
Timeframe: Baseline, Week 24

InterventionParticipants (Number)
Etanercept1

Number of Participants With a C to B Score Change From Baseline to Week 24 in the British Isles Lupus Assessment Group (BILAG) Mucocutaneous Score

Reported here is the number of participants with a change in their BILAG Mucocutaneous Score from C (at baseline) to B (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0). A maximum mucocutaneous score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system. (NCT00447265)
Timeframe: Baseline, Week 24

InterventionParticipants (Number)
Etanercept1

Number of Participants With an A to B Score Change From Baseline to Week 24 in the British Isles Lupus Assessment Group (BILAG) Renal Score

Reported here is the number of participants with a change in their BILAG Renal Score from A (at baseline) to B (at week 24). A single alphabetic score (A through E) is used to denote disease severity. The BILAG score is a converted numerical score (A=9, B=3, C=1, D=0, E=0).A maximum renal score of 9 signifies higher disease activity and a score of 0 is indicative of inactive systematic lupus erythematosus (SLE) in the specified organ system (NCT00447265)
Timeframe: Baseline, Week 24

InterventionParticipants (Number)
Etanercept1

Percent of Participants Who Achieved a Renal Response at Week 24

"Percent of study participants who achieved a renal response at 24 weeks.[1]~[1]A renal response is defined as: 1) 50% reduction in proteinuria compared to baseline as measured by urinary protein: creatinine ratio; and 2) stable or improving renal function as defined by the Glomerular filtration rate (GFR) calculated based on the Modification of Diet in Renal Disease equation (Levy, AS, Coresh J, Galk E et al, National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med, 139(2): 137-47, 2003)" (NCT00447265)
Timeframe: Week 24

InterventionPercent of Participants (Number)
Etanercept100

Time to Participant's Renal Response

"Time to when participant achieved a renal response[1]~[1]A renal response is defined as: 1) 50% reduction in proteinuria compared to baseline as measured by urinary protein: creatinine ratio; and 2) stable or improving renal function as defined by the Glomerular filtration rate (GFR) calculated based on the Modification of Diet in Renal Disease equation (Levy, AS, Coresh J, Galk E et al, National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med, 139(2): 137-47, 2003)" (NCT00447265)
Timeframe: First 24 Weeks of Study Period

InterventionWeeks (Number)
Etanercept24

Participant Medical Outcome Study Short Form 36 (SF-36) Mental Component Score at Baseline and Week 24

"Reported here are the participant SF-36 Mental Component scores at baseline and week 24. The SF-36 measures 8 domains: physical functioning, role limitations due to physical health, bodily pain, social functioning, mental health, role limitations due to emotional problems, vitality, and general health perceptions.[1] The Mental Component score of the SF-36 ranges from 0 to 100; 0 equals worst health state. Higher numbers reported here indicate more improvement in condition from baseline.~[1]Ref: Ware JE, Sherbourne CD. The MOS36-item short-form health survey. Med Care. 1992; 30:473-483" (NCT00447265)
Timeframe: Baseline, Week 24

InterventionScore on a scale (Number)
Baseline SF-36 Mental Component ScoreWeek 24 SF-36 Mental Component Score
Etanercept31.452.3

Participant Medical Outcome Study Short-Form 36 (SF-36) Physical Component Score at Baseline and Week 24

"Reported here is the participant baseline and week 24 SF-36 Physical Component scores. The SF-36 measures 8 domains: physical functioning, role limitations due to physical health, body pain, social functioning, mental health, role limitations due to emotional problems, vitality, and general health perceptions[1]. The Physical Component scores of the SF-36 range from 0 to 100; 0 equals worst health state. Higher numbers reported here indicate more improvement in condition from baseline.~[1]Ref: Ware JE, Sherbourne CD. The MOS36-item short-form health survey Med Care. 1992; 30:473-483." (NCT00447265)
Timeframe: Baseline, Week 24

InterventionScore on a scale (Number)
Baseline SF-36 Physical Component ScoreWeek 24 SF-36 Physical Component Score
Etanercept44.442.3

Participant Systematic Lupus Erythematosus Disease Activity Index (SLEDAI) Score at Baseline and at Early Study Withdrawal Visit

Reported here is the baseline and week 39 Systematic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. The SLEDAI is a concise measure of lupus disease activity with excellent test-retest reliability and high responsiveness to clinically important changes in the disease. The total score is derived from ratings on 24 conditions plus the Physician's Global Assessment; 0 indicates inactive disease and the maximum theoretical score is 105, with higher scores representing increased disease activity. (NCT00447265)
Timeframe: Baseline, Week 39 (Early Study Withdrawal Visit)

InterventionPoints on a scale (Number)
Baseline SLEDAI ScoreWeek 39 SLEDAI score
Etanercept228

Reviews

7 reviews available for azathioprine and Arthritis

ArticleYear
How to treat refractory arthritis in lupus?
    Joint bone spine, 2012, Volume: 79, Issue:4

    Topics: Abatacept; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal,

2012
Acute polyarthritis associated with azathioprine for interstitial lung disease.
    Respiratory medicine, 1995, Volume: 89, Issue:1

    Topics: Acute Disease; Arthritis; Azathioprine; Drug Hypersensitivity; Drug Therapy, Combination; Female; Hu

1995
The protean manifestations of Crohn's disease.
    Postgraduate medicine, 1975, Volume: 57, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Arthritis; Azathioprine; Child; Colectomy; Colitis,

1975
Inflammatory disease of the colon: ulcerative colitis and Crohn's colitis.
    The Journal of pediatrics, 1975, Volume: 86, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Anus Diseases; Arthritis; Azathioprine; Child, Preschool; Colectomy;

1975
Cytotoxic drugs: their clinical application to the rheumatic diseases.
    Seminars in arthritis and rheumatism, 1986, Volume: 15, Issue:4

    Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica

1986
An updated look at antirheumatic drugs.
    The Medical clinics of North America, 1967, Volume: 51, Issue:5

    Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis; Azathioprine; Chloroquine; Cyclophosphamide; Gluco

1967
[Current status of immunosuppressive therapy in non-neoplastic disorders].
    Schweizerische medizinische Wochenschrift, 1970, Apr-18, Volume: 100, Issue:16

    Topics: Arthritis; Autoimmune Diseases; Azathioprine; Bone Marrow; Bone Marrow Diseases; Chemical Phenomena;

1970

Trials

2 trials available for azathioprine and Arthritis

ArticleYear
[Therapy evaluation in rheumatology with an electronic data processing system].
    Acta medica Austriaca, 1976, Volume: 3, Issue:2

    Topics: Anti-Inflammatory Agents; Arthritis; Azathioprine; Clinical Trials as Topic; Computers; Cyclophospha

1976
Controlled trial of azathioprine in Crohn's disease.
    Lancet (London, England), 1971, Dec-11, Volume: 2, Issue:7737

    Topics: Adolescent; Adult; Aged; Arthritis; Azathioprine; Clinical Trials as Topic; Crohn Disease; Double-Bl

1971

Other Studies

65 other studies available for azathioprine and Arthritis

ArticleYear
Nodular Regenerative Hyperplasia of the liver in Juvenile Dermatomyositis.
    Pediatric rheumatology online journal, 2022, Apr-20, Volume: 20, Issue:1

    Topics: Abatacept; Adolescent; Arthritis; Autoantibodies; Azathioprine; Calcinosis; Child; Cyclophosphamide;

2022
Perspective of sarcoidosis in terms of rheumatology: a single-center rheumatology clinic experience.
    Rheumatology international, 2022, Volume: 42, Issue:12

    Topics: Adrenal Cortex Hormones; Ambulatory Care Facilities; Anti-Inflammatory Agents, Non-Steroidal; Arthri

2022
Abdominal pain, rash, and arthritis.
    Clinical pediatrics, 2015, Volume: 54, Issue:5

    Topics: Abdominal Pain; Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Azathioprine;

2015
Pulmonary extramedullary hematopoiesis.
    Journal of thoracic imaging, 2008, Volume: 23, Issue:2

    Topics: Anemia, Hemolytic; Antirheumatic Agents; Arthritis; Azathioprine; Biopsy, Fine-Needle; Diagnosis, Di

2008
Autoimmune hypothyroidism and lupus-like syndrome.
    Rheumatology international, 2010, Volume: 30, Issue:4

    Topics: Adult; Arthritis; Azathioprine; Biphenyl Compounds; Complement C3; Complement C4; Complement System

2010
Increased plasma myeloperoxidase levels in systemic lupus erythematosus.
    Rheumatology international, 2010, Volume: 30, Issue:6

    Topics: Adult; Age of Onset; Antimalarials; Arthritis; Azathioprine; Biomarkers; Cross-Sectional Studies; Cy

2010
A case of granulomatous mastitis with erythema nodosum and arthritis.
    Rheumatology international, 2011, Volume: 31, Issue:8

    Topics: Antirheumatic Agents; Arthritis; Azathioprine; Colchicine; Drug Therapy, Combination; Erythema Nodos

2011
Infliximab for the treatment of refractory Adamantiades-Behçet disease with articular, intestinal, cerebral and ocular involvement.
    Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3

    Topics: Adolescent; Antibodies, Monoclonal; Arthritis; Aspirin; Azathioprine; Behcet Syndrome; Chronic Disea

2010
Infliximab, azathioprine, or combination therapy for Crohn's disease.
    The New England journal of medicine, 2010, 09-09, Volume: 363, Issue:11

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Arthritis; Azathioprine; Crohn Disease; Drug Thera

2010
Behçet disease presenting with frosted branch angiitis.
    Ocular immunology and inflammation, 2011, Volume: 19, Issue:1

    Topics: Arthritis; Azathioprine; Behcet Syndrome; Fundus Oculi; Hematocele; HLA-B Antigens; HLA-B51 Antigen;

2011
Fatal rhabdomyolysis in systemic lupus erythematosus.
    Rheumatology international, 2011, Volume: 31, Issue:9

    Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Antibodies, Antinuclear; Arthritis; Azathioprine;

2011
Churg-Strauss syndrome: diagnostic difficulties and pathogenesis.
    The American journal of the medical sciences, 2003, Volume: 325, Issue:2

    Topics: Antirheumatic Agents; Arthritis; Azathioprine; Churg-Strauss Syndrome; Female; Humans; Middle Aged;

2003
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:10

    Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter

2004
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:10

    Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter

2004
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:10

    Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter

2004
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:10

    Topics: Adult; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Autoantibodies; Azathioprine; Bacter

2004
[Symmetric polyarthritis in a patient with Churg-Strauss syndrome].
    Deutsche medizinische Wochenschrift (1946), 2005, Aug-19, Volume: 130, Issue:33

    Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Azathioprine; Churg-Strauss Syndrome; Cyclo

2005
Azathioprine-induced shock in a patient suffering from undifferentiated erosive oligoarthritis.
    The Netherlands journal of medicine, 2006, Volume: 64, Issue:4

    Topics: Anaphylaxis; Antirheumatic Agents; Arthritis; Azathioprine; Humans; Immunosuppressive Agents; Male;

2006
Anti-Jo-1 antibody positive polymyositis--successful therapy with leflunomide.
    Autoimmunity, 2006, Volume: 39, Issue:3

    Topics: Antibodies, Antinuclear; Arthritis; Autoantibodies; Azathioprine; Drug Therapy, Combination; Female;

2006
Unusual presentation of non-Hodgkin lymphoma: polyarthritis and uveitis mimicking a rheumatologic disease.
    Rheumatology international, 2008, Volume: 28, Issue:6

    Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middl

2008
CINCA Syndrome.
    Indian pediatrics, 2007, Volume: 44, Issue:12

    Topics: Age Factors; Arthritis; Azathioprine; Carrier Proteins; Child; Chronic Disease; Erythema; Female; Fe

2007
Peripheral gangrene in infancy and childhood.
    British medical journal, 1967, Feb-25, Volume: 1, Issue:5538

    Topics: Arthritis; Azathioprine; Child, Preschool; Female; Gangrene; Humans; Hyperbaric Oxygenation; Infant;

1967
Multicentric reticulohistiocytosis.
    Dermatologica, 1984, Volume: 169, Issue:5

    Topics: Arthritis; Azathioprine; Humans; Lymphatic Diseases; Male; Middle Aged; Myositis; Skin Neoplasms

1984
Azathioprine.
    Clinics in rheumatic diseases, 1984, Volume: 10, Issue:2

    Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Female; Gastrointestinal Diseases; Humans; Leukopeni

1984
[Combined use of prodigiozan and methyluracil with immunosuppressive drugs in adjuvant arthritis in rats].
    Antibiotiki, 1984, Volume: 29, Issue:11

    Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Cyclophosphamide; Drug Interactions; Drug

1984
Arthritis and angioimmunoblastic lymphadenopathy.
    Annals of the rheumatic diseases, 1983, Volume: 42, Issue:5

    Topics: Aged; Arthritis; Azathioprine; Female; Humans; Immunoblastic Lymphadenopathy; Lymph Nodes; Middle Ag

1983
Therapeutic plasmapheresis in systemic lupus erythematosus. Effect on immune complexes and antibodies to DNA.
    Arthritis and rheumatism, 1981, Volume: 24, Issue:9

    Topics: Adolescent; Adult; Antibodies, Antinuclear; Antigen-Antibody Complex; Arthritis; Azathioprine; Chlor

1981
Influence of adjuvant arthritis on main urinary metabolites of prostaglandin F and E in rats.
    Prostaglandins, 1980, Volume: 19, Issue:2

    Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Indomethacin; Male; Prednisolone; Prostag

1980
[Refractory idiopathic liquefying panniculitis].
    Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Azathioprine; Diclofenac; Drug Resistance

1995
Systemic lupus erythematosus and bone marrow necrosis in a dog.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1996, Volume: 37, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis; Azathio

1996
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
    Arthritis and rheumatism, 1997, Volume: 40, Issue:10

    Topics: Adolescent; Antirheumatic Agents; Arthritis; Azathioprine; Female; HLA-B27 Antigen; Homozygote; Huma

1997
[Reactive arthritis. Diagnosis, differential diagnosis and therapy].
    Fortschritte der Medizin, 1999, Mar-10, Volume: 117, Issue:7

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Reactive; Arthritis, R

1999
Photo quiz. Drug-induced pemphigus foliaceus.
    Cutis, 2000, Volume: 66, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Stero

2000
[Collagenous colitis. A study of 11 cases].
    Annales de medecine interne, 2001, Volume: 152, Issue:5

    Topics: Adult; Agammaglobulinemia; Aged; Aged, 80 and over; Anemia; Anti-Inflammatory Agents; Anti-Inflammat

2001
Chronic infantile neurological cutaneous and articular syndrome: two new cases with rare manifestations.
    Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:9

    Topics: Abnormalities, Multiple; Antirheumatic Agents; Arthritis; Azathioprine; Child, Preschool; Chronic Di

2001
Noninfectious canine arthritis: the inflammatory, nonerosive arthritides.
    Journal of the American Veterinary Medical Association, 1976, Aug-01, Volume: 169, Issue:3

    Topics: Animals; Arthritis; Arthritis, Infectious; Azathioprine; Cyclophosphamide; Dog Diseases; Dogs; Femal

1976
[Enteritis regionalis (Crohn's disease) (proceedings)].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1976, Issue:12

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Amyloidosis; Arthritis; Azathioprine; Child; Child

1976
Azathioprine treatment of adjuvant arthritis.
    Journal of immunopharmacology, 1979, Volume: 1, Issue:4

    Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Female; Mycobacterium; Rats

1979
Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 201, Issue:1

    Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Cell Line; Cyclophosphamide; Edema; Freun

1977
A case of pulmonary veno-occlusive disease respondong to treatment with azathioprine.
    Thorax, 1977, Volume: 32, Issue:2

    Topics: Alopecia; Arthritis; Azathioprine; Female; Humans; Middle Aged; Pulmonary Veins; Raynaud Disease; Sk

1977
[Treatment of psoriasis arthropathy with either azathioprine or methotrexate (author's transl)].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, May-25, Volume: 65, Issue:21

    Topics: Adult; Arthritis; Azathioprine; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis

1976
[Cytotoxic treatment of chronic joint diseases].
    L'union medicale du Canada, 1976, Volume: 105, Issue:4

    Topics: Adult; Arthritis; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Cyclophosphamide; Drug Evalu

1976
Frontiers in inflammatory bowel disease. The proceedings of a conference sponsored by the McReynolds Foundation. Part II.
    The American journal of digestive diseases, 1975, Volume: 20, Issue:7

    Topics: Adenocarcinoma; Arthritis; Azathioprine; Child; Chronic Disease; Colitis, Ulcerative; Colonic Neopla

1975
Studies on the effects of pharmacological agents on antigen-induced arthritis in BALB/c mice.
    Drugs under experimental and clinical research, 1987, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arthritis; Arthritis, Experimental; Azat

1987
Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs.
    Annals of the rheumatic diseases, 1986, Volume: 45, Issue:6

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Azathioprine; Calcium-Bi

1986
[An analysis of the morbid condition in adjuvant arthritic rats and a new method for evaluating anti-rheumatic drugs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1988, Volume: 92, Issue:2

    Topics: Animals; Arthritis; Arthritis, Experimental; Azathioprine; Drug Evaluation, Preclinical; Gold Sodium

1988
Benign hypergammaglobulinemic purpura in a patient with ulcerative colitis and peripheric arthritis.
    Clinical rheumatology, 1988, Volume: 7, Issue:4

    Topics: Adult; Arthritis; Azathioprine; Colitis, Ulcerative; Humans; Male; Prednisone; Purpura, Hyperglobuli

1988
Adverse reactions to azathioprine mimicking gastroenteritis.
    The Journal of rheumatology, 1987, Volume: 14, Issue:5

    Topics: Adult; Arthritis; Azathioprine; Female; Gastroenteritis; Humans; Psoriasis

1987
Abnormal calcium and magnesium stores in erythrocytes and granulocytes from patients with inflammatory connective tissue diseases. Relationship to inflammatory activity and effect of corticosteroid therapy.
    Arthritis and rheumatism, 1985, Volume: 28, Issue:2

    Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Azathioprine; Calcium; Cyclophosphamide;

1985
[Inhibition of immunologically induced inflammation by the plant steroid withaferin A].
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:7

    Topics: Adjuvants, Immunologic; Animals; Arthritis; Azathioprine; Chick Embryo; Chickens; Cholestanes; Cyclo

1973
Effect of predosing animals with immunosuppressive drugs on immune and non-immune induced inflammatory responses.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 211, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Arthritis; Azathioprine; Carrageenan; Cyclophosphamide; Dexamethaso

1974
Preliminary results of azathioprine treatment in severe rheumatic disease.
    Annals of physical medicine, 1969, Volume: 10, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Azathioprine; Blood Cell

1969
Treatment of psoriatic arthropathy with either azathioprine or methotrexate.
    Rheumatology and rehabilitation, 1974, Volume: 13, Issue:3

    Topics: Adult; Arthritis; Azathioprine; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis

1974
[Reiter's disease in the female].
    Schweizerische medizinische Wochenschrift, 1974, Aug-31, Volume: 104, Issue:35

    Topics: Adult; Arthritis; Arthritis, Reactive; Aspirin; Azathioprine; Biopsy; Female; Humans; Liver; Methylp

1974
Some aspects of anti-inflammatory action of immunosuppressive drugs.
    Japanese journal of pharmacology, 1974, Volume: 24, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Azathio

1974
Radiation reversal of acute rejection in patients with life-threatening infections.
    Archives of surgery (Chicago, Ill. : 1960), 1973, Volume: 107, Issue:2

    Topics: Adult; Antilymphocyte Serum; Arthritis; Azathioprine; Bacterial Infections; Cobalt Isotopes; Dose-Re

1973
The effect of azathioprine on gammaglobulin synthesis in man.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:9

    Topics: Antibodies, Antinuclear; Arthritis; Arthritis, Rheumatoid; Azathioprine; Chromatography, DEAE-Cellul

1972
The effect of immunosuppression on polyarthritis induced by Mycoplasma arthritidis in rats.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1973, Apr-10, Volume: 19, Issue:4

    Topics: Animals; Arthritis; Azathioprine; Chlorambucil; Cyclophosphamide; Immune Sera; Immunosuppressive Age

1973
Letter: Reaction to azathioprine.
    Canadian Medical Association journal, 1973, Dec-01, Volume: 109, Issue:11

    Topics: Adult; Arthritis; Azathioprine; Fever; Humans; Liver Cirrhosis; Male

1973
[Changes of mucopolysaccharase, protease and collagenolytic activities in rats with adjuvant arthritis and the effects of various anti-inflammatory drugs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Azathioprine; Barbiturates; Chloroquine; Collagen; Cyc

1973
Comparison of the effects of two cytotoxic drugs and of antilymphocytic serum on immune and non-immune inflammation in experimental animals.
    Annals of the rheumatic diseases, 1970, Volume: 29, Issue:1

    Topics: Animals; Antilymphocyte Serum; Arthritis; Azathioprine; Cyclophosphamide; DNA Replication; Exudates

1970
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
    Pharmacology, 1971, Volume: 5, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch

1971
[Case report on the treatment with azathioprine of collagen diseases].
    Das Deutsche Gesundheitswesen, 1971, Jan-01, Volume: 26, Issue:1

    Topics: Adult; Arthritis; Autoimmune Diseases; Azathioprine; Chronic Disease; Collagen Diseases; Dermatomyos

1971
A comparison of immunosuppressive and anti-inflammatory agents in the rat.
    Clinical and experimental immunology, 1971, Volume: 9, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Antilymphocyte Serum; Arthritis; Azathioprine

1971
[Long-term studies on indomethacin in rheumatology with special reference to its use in combination with azathioprine].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:11

    Topics: Administration, Oral; Arthritis; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Drug Combinat

1971
The nature and treatment of psoriasis.
    The Medical journal of Australia, 1969, Jun-07, Volume: 1, Issue:23

    Topics: Adrenal Cortex Hormones; Antibodies, Antinuclear; Arthritis; Azathioprine; Diagnosis, Differential;

1969
[Basic therapy of progressive chronic arthritis. 2].
    Therapie der Gegenwart, 1970, Volume: 109, Issue:11

    Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Arthritis; Azathioprine; Chronic Disease;

1970
[Immunosuppressive therapy with antimetabolites].
    Therapeutische Umschau. Revue therapeutique, 1967, Volume: 24, Issue:4

    Topics: Adrenal Cortex Hormones; Antimetabolites; Arthritis; Azathioprine; Blood Sedimentation; Humans; Immu

1967