Page last updated: 2024-10-23

azathioprine and Arthralgia

azathioprine has been researched along with Arthralgia in 11 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Arthralgia: Pain in the joint.

Research Excerpts

ExcerptRelevanceReference
"In most patients with autoimmune hepatitis, remission can be maintained with prednisolone, usually in combination with azathioprine, but the majority of patients have a relapse when treatment is stopped and therefore require long-term therapy."9.08Azathioprine for long-term maintenance of remission in autoimmune hepatitis. ( Johnson, PJ; McFarlane, IG; Williams, R, 1995)
"In most patients with autoimmune hepatitis, remission can be maintained with prednisolone, usually in combination with azathioprine, but the majority of patients have a relapse when treatment is stopped and therefore require long-term therapy."5.08Azathioprine for long-term maintenance of remission in autoimmune hepatitis. ( Johnson, PJ; McFarlane, IG; Williams, R, 1995)
" We report a case of a 13-year-old girl who presented with orofacial swelling and arthralgia, who eventually was diagnosed with Crohn's disease, which was successfully treated with infliximab and azathioprine combination therapy."3.83Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease. ( Benninga, MA; D'Haens, GR; Hoekman, DR; Roelofs, JJ; Schonenberg-Meinema, D; van Schuppen, J, 2016)
"Pharmacogenetic studies in inflammatory bowel diseases (IBD) are mainly focused on genes involved in the metabolism of Azathioprine (AZA)."3.77A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine. ( Barreiro-de Acosta, M; Barros, F; Carpio, D; Carracedo, A; Castro, J; Corton, M; Echarri, A; Lorenzo, A; Martin-Granizo, I; Martínez-Ares, D; Pereira, S; Zabala-Fernández, W, 2011)
" Azathioprine has a significant early adverse reaction (EAR) profile, which includes an acute syndrome of constitutional symptoms, fever, rash, and acute pancreatitis and often requires discontinuation of drug."3.73Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. ( Bajaj, JS; Binion, DG; Emmons, J; Franco, J; Knox, JF; Levy, M; Podoll, J; Saeian, K; Varma, RR, 2005)
"Arthralgias is a common manifestation of vedolizumab treatment."1.91Prevalence and predictors of arthralgia after initiation of vedolizumab in patients with inflammatory bowel disease: a retrospective cohort study. ( Bamias, G; Benetou, V; Gaki, A; Giotis, I; Kitsou, V; Kokkotis, G; Lagiou, P; Leonidakis, G; Leontidis, N; Michopoulos, S; Orfanos, P; Stoupaki, M; Tzouvala, M; Zampeli, E, 2023)
"Hydroxychloroquine was most frequently used (88."1.62Clinical features and outcomes from the Singapore Sjögren's syndrome study. ( Charan, N; Kam, JK; Leong, RW; Loh, ZW; Thong, BY, 2021)
" The use of bosentan for vasculitis had not been reported in children before the treatment of our patient, so its dosage was based on that used to produce vasodilation in children with pulmonary hypertension."1.34Polyarteritis nodosa resistant to conventional treatment in a pediatric patient. ( García-Consuegra, J; González-Fernández, MA, 2007)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's4 (36.36)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Kokkotis, G1
Zampeli, E1
Tzouvala, M1
Giotis, I1
Orfanos, P1
Benetou, V1
Stoupaki, M1
Leontidis, N1
Leonidakis, G1
Kitsou, V1
Gaki, A1
Lagiou, P1
Michopoulos, S1
Bamias, G1
Kam, JK1
Charan, N1
Leong, RW1
Loh, ZW1
Thong, BY1
Mederacke, I1
Wiestler, M1
Wedemeyer, H1
Kohli, R1
Siva, C1
Hoekman, DR1
Roelofs, JJ1
van Schuppen, J1
Schonenberg-Meinema, D1
D'Haens, GR1
Benninga, MA1
Ardalan, ZS1
Vasudevan, A1
Testro, AG1
Zabala-Fernández, W1
Barreiro-de Acosta, M1
Echarri, A1
Carpio, D1
Lorenzo, A1
Castro, J1
Martínez-Ares, D1
Pereira, S1
Martin-Granizo, I1
Corton, M1
Carracedo, A1
Barros, F1
Bajaj, JS1
Saeian, K1
Varma, RR1
Franco, J1
Knox, JF1
Podoll, J1
Emmons, J1
Levy, M1
Binion, DG1
González-Fernández, MA1
García-Consuegra, J1
Johnson, PJ1
McFarlane, IG1
Williams, R1
Gause, A1
Inderrieden, DC1
Laas, R1
Arlt, AC1
Gross, WL1

Trials

1 trial available for azathioprine and Arthralgia

ArticleYear
Azathioprine for long-term maintenance of remission in autoimmune hepatitis.
    The New England journal of medicine, 1995, Oct-12, Volume: 333, Issue:15

    Topics: Adolescent; Adult; Aged; Arthralgia; Autoimmune Diseases; Azathioprine; Disease-Free Survival; Femal

1995

Other Studies

10 other studies available for azathioprine and Arthralgia

ArticleYear
Prevalence and predictors of arthralgia after initiation of vedolizumab in patients with inflammatory bowel disease: a retrospective cohort study.
    European journal of gastroenterology & hepatology, 2023, 04-01, Volume: 35, Issue:4

    Topics: Arthralgia; Azathioprine; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Inflammatory Bowel D

2023
Clinical features and outcomes from the Singapore Sjögren's syndrome study.
    Lupus, 2021, Volume: 30, Issue:2

    Topics: Adult; Arthralgia; Azathioprine; Female; Humans; Hydroxychloroquine; Keratoconjunctivitis Sicca; Mal

2021
An Unusual Cause of Erythema on Both Lower Legs in a Patient With Crohn's Disease.
    Gastroenterology, 2022, Volume: 162, Issue:3

    Topics: Arthralgia; Azathioprine; C-Reactive Protein; Cough; Crohn Disease; Drug Hypersensitivity Syndrome;

2022
Diplopia, Proptosis, and Joint Pain: Possibility of Osseous and Orbital Sarcoidosis.
    The Journal of rheumatology, 2018, Volume: 45, Issue:1

    Topics: Adult; Arthralgia; Azathioprine; Biopsy; Diplopia; Exophthalmos; Finger Phalanges; Humans; Lacrimal

2018
Case report of cheilitis granulomatosa and joint complaints as presentation of Crohn's disease.
    Clinical journal of gastroenterology, 2016, Volume: 9, Issue:2

    Topics: Adolescent; Arthralgia; Azathioprine; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combinat

2016
Arthralgia and Fevers in a Patient With Autoimmune Hepatitis.
    JAMA, 2016, Jul-05, Volume: 316, Issue:1

    Topics: Aged; Arthralgia; Azathioprine; Drug Hypersensitivity; Erythema Nodosum; Exanthema; Fever; Hepatitis

2016
A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine.
    Journal of gastrointestinal and liver diseases : JGLD, 2011, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Arthralgia; Azathioprine; Bone Marrow; Child; Female; Genotype; Humans; Inf

2011
Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:5

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Arthralgia; Azathioprine; Crohn Disease; Disease Sus

2005
Polyarteritis nodosa resistant to conventional treatment in a pediatric patient.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:5

    Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Arthralgia; Azathioprine; Bosentan; Child, Presch

2007
Common variable immunodeficiency (CVID) and inclusion body myositis (IBM).
    Immunobiology, 2000, Volume: 202, Issue:2

    Topics: Adult; Arthralgia; Azathioprine; Common Variable Immunodeficiency; Fatigue; gamma-Globulins; Humans;

2000