azathioprine has been researched along with Antiphospholipid Syndrome in 29 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Antiphospholipid Syndrome: The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy." | 7.83 | The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016) |
| "Primary myelofibrosis was diagnosed because of bone marrow fibrosis and extramedullary hematopoiesis of the spleen." | 5.29 | [Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine]. ( Kawamura, Y; Niki, T, 1995) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy." | 3.83 | The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016) |
| " Compared to controls, cases were higher in body mass index, anti-dsDNA antibody, prevalence of hypertension, antiphospholipid syndrome, and use of immunosuppressive medication, especially azathioprine and methotrexate; they were lower in IgM." | 3.78 | Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus. ( Aghdassi, E; Fortin, PR; Gladman, DD; Hirschfield, GM; Huang, D; Mosko, J; Su, J; Urowitz, MB, 2012) |
| "Relapsing polychondritis is a rare immune-mediated condition, characterized by episodic inflammation of the cartilaginous tissue, in particular the ears, nose, and eyes, and involvement of joints and respiratory tract." | 2.49 | Unusual association between Budd-Chiari syndrome secondary to antiphospholipid syndrome and relapsing polychondritis: a case report and review of the literature. ( Campomori, F; Ferri, C; Giuggioli, D; Giuggoli, D; Manzini, CU; Schepis, F; Sebastiani, M; Spinella, A; Vacchi, C, 2013) |
| "Optic neuropathy is a well-known ocular manifestation occurring in patients with systemic lupus erythematosus (SLE), and it remains one of the major causes of blindness in these patients." | 2.40 | Optic neuropathy in systemic lupus erythematosus and antiphospholipid syndrome (APS): clinical features, pathogenesis, review of the literature and proposed ophthalmological criteria for APS diagnosis. ( Balacco Gabrieli, C; Giorgi, D, 1999) |
| "In two patients with primary antiphospholipid antibody syndrome and acute cerebrovascular ischemic events, local intraarterial fibrinolysis and intravenous heparin therapy, respectively, resulted in a limitation of persisting neurological deficits." | 2.38 | Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options. ( Braune, S; Lücking, CH; Siekmann, R; Vaith, P, 1993) |
| "Neuromyelitis optica (NMO or Devic's syndrome) is a rare autoimmune disease, previously considered a multiple sclerosis variant." | 1.36 | Devic's syndrome and primary APS: a new immunological overlap. ( Colagrande, S; Emmi, L; Squatrito, D, 2010) |
| "Primary Antiphospholipid Antibody Syndrome (PAPS) and Autoimmune haemolytic anemia (AIHA) is a very rare combination." | 1.35 | Primary antiphospholipid antibody syndrome and autoimmune haemolytic anaemia--a rare combination. ( Baig, MS; Humail, SM; Riaz, A; Suhail, S, 2009) |
| "However, bleeding is rare in this syndrome." | 1.35 | Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome. ( Abdallah, TB; Beji, S; El Younsi, F; Ezzine, S; Guermazi, S; Hamida, FB; Kaaroud, H; Kheder, A; Moussa, FB, 2008) |
| "Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare disorder characterized by a bleeding tendency due to factor II deficiency associated with the presence of lupus anticoagulant (LAC) autoantibodies." | 1.33 | Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome. ( Rich, E; Senécal, JL; Vinet, E, 2006) |
| "Life threatening cardiac arrhythmia was the first clinical manifestation of the disease." | 1.33 | [Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome]. ( Laskowska, K; Majdan, M; Suszek, D; Targońska-Stepniak, B, 2006) |
| "The diagnostic criteria for systemic lupus erythematosus (SLE) were not fulfilled either." | 1.32 | Late puerperal thrombohemorrhagic complications in a patient with antiphospholipid syndrome. ( Bladt, V; d'Amore, F; Laursen, B; Petersen, OB; Poulsen, LH; Steengaard-Pedersen, K, 2004) |
| "A diagnosis of mixed connective tissue disease (Sharp-syndrome) was established." | 1.30 | [A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome]. ( Hartmann, F; Kranzhöfer, N; Lindemuth, R; Zuber, M, 1998) |
| "Primary myelofibrosis was diagnosed because of bone marrow fibrosis and extramedullary hematopoiesis of the spleen." | 1.29 | [Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine]. ( Kawamura, Y; Niki, T, 1995) |
| " Moreover, progressive renal insufficiency can develop as a result of the long-term use of this drug." | 1.29 | Immunosuppressive treatment in a heart transplantation candidate with antiphospholipid syndrome. ( Agostini, C; Biasiolo, A; De Silvestro, G; Livi, U; Marson, P; Pengo, V, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sebastiani, M | 1 |
| Manzini, CU | 1 |
| Campomori, F | 1 |
| Spinella, A | 1 |
| Vacchi, C | 1 |
| Giuggioli, D | 1 |
| Giuggoli, D | 1 |
| Schepis, F | 1 |
| Ferri, C | 1 |
| Yachoui, R | 1 |
| Sehgal, R | 1 |
| Amlani, B | 1 |
| Goldberg, JW | 1 |
| Sciascia, S | 1 |
| Hunt, BJ | 1 |
| Talavera-Garcia, E | 1 |
| Lliso, G | 1 |
| Khamashta, MA | 1 |
| Cuadrado, MJ | 1 |
| Korkmaz, C | 2 |
| Suhail, S | 1 |
| Baig, MS | 1 |
| Humail, SM | 1 |
| Riaz, A | 1 |
| Tarner, IH | 1 |
| Lange, U | 1 |
| Madlener, K | 1 |
| Classen, K | 1 |
| Kandolf, R | 1 |
| Sperzel, J | 1 |
| Müller-Ladner, U | 1 |
| Squatrito, D | 1 |
| Colagrande, S | 1 |
| Emmi, L | 1 |
| Prado, DM | 1 |
| Gualano, B | 1 |
| Pinto, AL | 1 |
| Sallum, AM | 1 |
| Perondi, MB | 1 |
| Roschel, H | 1 |
| Silva, CA | 1 |
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Huang, D | 1 |
| Aghdassi, E | 1 |
| Su, J | 1 |
| Mosko, J | 1 |
| Hirschfield, GM | 1 |
| Gladman, DD | 1 |
| Urowitz, MB | 1 |
| Fortin, PR | 1 |
| Noaiseh, G | 1 |
| Bhangle, S | 1 |
| Vivino, F | 1 |
| Kabukcuoğlu, S | 1 |
| Isiksoy, S | 1 |
| Yalçin, AU | 1 |
| Hadjigogos, K | 1 |
| Marinaki, P | 1 |
| Bladt, V | 1 |
| Steengaard-Pedersen, K | 1 |
| Poulsen, LH | 1 |
| Petersen, OB | 1 |
| Laursen, B | 1 |
| d'Amore, F | 1 |
| Chen, HC | 1 |
| Lai, JH | 1 |
| Huang, GS | 1 |
| Gao, HW | 1 |
| Chen, CH | 1 |
| Kuo, SY | 1 |
| Chang, DM | 1 |
| Foster, R | 1 |
| Rosenthal, E | 1 |
| Marques, S | 1 |
| Vounotrypidis, P | 1 |
| Sangle, S | 1 |
| D'Cruz, D | 1 |
| Vinet, E | 1 |
| Rich, E | 1 |
| Senécal, JL | 1 |
| Patterson, SL | 1 |
| LaMonte, MP | 1 |
| Mikdashi, JA | 1 |
| Haines, ST | 1 |
| Hursting, MJ | 1 |
| Targońska-Stepniak, B | 1 |
| Majdan, M | 1 |
| Suszek, D | 1 |
| Laskowska, K | 1 |
| Kaaroud, H | 1 |
| Beji, S | 1 |
| Guermazi, S | 1 |
| Moussa, FB | 1 |
| Hamida, FB | 1 |
| Ezzine, S | 1 |
| Abdallah, TB | 1 |
| El Younsi, F | 1 |
| Kheder, A | 1 |
| Niki, T | 1 |
| Kawamura, Y | 1 |
| Bühler-Singer, S | 1 |
| von Hintzenstern, J | 1 |
| Fartasch, M | 1 |
| Hornstein, OP | 1 |
| Braune, S | 1 |
| Siekmann, R | 1 |
| Vaith, P | 1 |
| Lücking, CH | 1 |
| Pengo, V | 1 |
| Biasiolo, A | 1 |
| Marson, P | 1 |
| De Silvestro, G | 1 |
| Agostini, C | 1 |
| Livi, U | 1 |
| Cockwell, P | 1 |
| Zuber, M | 1 |
| Kranzhöfer, N | 1 |
| Lindemuth, R | 1 |
| Hartmann, F | 1 |
| Giorgi, D | 1 |
| Balacco Gabrieli, C | 1 |
| Stratta, P | 1 |
| Canavese, C | 1 |
| Santi, S | 1 |
| Ciccone, G | 1 |
| Rosso, S | 1 |
| Salim, S | 1 |
| Salim, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-blind, Randomized and Parallel Controlled Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Miscarriage With Antiphospholipid Syndrome[NCT04624269] | Phase 4 | 384 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | ||
| A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174] | 420 participants (Anticipated) | Interventional | 2019-08-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for azathioprine and Antiphospholipid Syndrome
| Article | Year |
|---|---|
Unusual association between Budd-Chiari syndrome secondary to antiphospholipid syndrome and relapsing polychondritis: a case report and review of the literature.
Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Budd-Chiari Syndrome; Comorbi | 2013 |
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Anticoagulants; Antiphospholipid Syndrome; An | 2005 |
Primary systemic vasculitis: treatment of difficult cases.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antiphospholipid; Antibodies, Monoclonal; Antibo | 2006 |
Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Azathioprine; Brain Ischemia; Dexamethasone; Hu | 2006 |
Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options.
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Brain Ischemia; Cyclophosphamide; Enzyme-Linked Immu | 1993 |
Optic neuropathy in systemic lupus erythematosus and antiphospholipid syndrome (APS): clinical features, pathogenesis, review of the literature and proposed ophthalmological criteria for APS diagnosis.
Topics: Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprin | 1999 |
22 other studies available for azathioprine and Antiphospholipid Syndrome
| Article | Year |
|---|---|
Antiphospholipid antibodies-associated diffuse alveolar hemorrhage.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azath | 2015 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
Do immunosuppressives upregulate antiphospholid antibodies?
Topics: Antiphospholipid Syndrome; Autoantibodies; Autoimmune Diseases; Azathioprine; Biomarkers; Cardiolipi | 2009 |
Primary antiphospholipid antibody syndrome and autoimmune haemolytic anaemia--a rare combination.
Topics: Adolescent; Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Anticoagulants; Antiphospholipid | 2009 |
[A wolf in sheep's clothing: atypical systemic lupus erythematosus (SLE) presenting as cardiovascular disease].
Topics: Antiphospholipid Syndrome; Azathioprine; Biopsy; Diagnosis, Differential; Female; Heart Failure; Hea | 2010 |
Devic's syndrome and primary APS: a new immunological overlap.
Topics: Antiphospholipid Syndrome; Azathioprine; Humans; Immunosuppressive Agents; Magnetic Resonance Imagin | 2010 |
Exercise in a child with systemic lupus erythematosus and antiphospholipid syndrome.
Topics: Adolescent; Anaerobic Threshold; Antiphospholipid Syndrome; Azathioprine; Drug Therapy, Combination; | 2011 |
Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus.
Topics: Adult; Alanine Transaminase; Antibodies, Neutralizing; Antiphospholipid Syndrome; Aspartate Aminotra | 2012 |
Idiopathic mediastinal fibrosis presenting with antiphospholipid antibody syndrome and manifestations suggestive of connective tissue disease.
Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Antirheumatic Agents; Azathioprine; Connecti | 2012 |
Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy.
Topics: Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Female; Glomeruloscler | 2003 |
Autoimmune hepatitis and the antiphospholipid antibody syndrome. A case report.
Topics: Adult; Antiphospholipid Syndrome; Aspirin; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Pred | 2003 |
Late puerperal thrombohemorrhagic complications in a patient with antiphospholipid syndrome.
Topics: Abortion, Habitual; Activated Protein C Resistance; Adult; Anticoagulants; Antiphospholipid Syndrome | 2004 |
Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome.
Topics: Adrenal Cortex Hormones; Antiphospholipid Syndrome; Azathioprine; Central Nervous System Diseases; C | 2006 |
[Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome].
Topics: Adult; Antibodies, Antinuclear; Antiphospholipid Syndrome; Arrhythmias, Cardiac; Autoantibodies; Aut | 2006 |
Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome.
Topics: Adrenal Cortex Hormones; Adult; Anticoagulants; Antiphospholipid Syndrome; Azathioprine; Female; Hem | 2008 |
[Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine].
Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Female; Humans; Middle Aged; | 1995 |
[Anticardiolipin syndrome with only skin involvement].
Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Arm; Aspirin; Azathioprine; Combined | 1994 |
Immunosuppressive treatment in a heart transplantation candidate with antiphospholipid syndrome.
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Cardiomyopathy, Dilated; Cyclosporine; Drug Therapy, | 1996 |
Systemic lupus erythematosus [clinical inference].
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Cyclophosphamide; Female; Humans; Lupus Erythematosu | 1997 |
[A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome].
Topics: Adult; Antiphospholipid Syndrome; Aspirin; Azathioprine; Biopsy; Diagnosis, Differential; Drug Thera | 1998 |
Systemic lupus erythematosus.
Topics: Antiphospholipid Syndrome; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Humans; Immunogl | 2001 |
Antiphospholipid antibody syndrome of systemic lupus erythematosus presenting as deep vein thrombosis.
Topics: Adolescent; Adrenal Cortex Hormones; Anticoagulants; Antiphospholipid Syndrome; Azathioprine; Female | 1992 |