azathioprine has been researched along with Anti-Phospholipid Antibody Syndrome in 29 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy." | 7.83 | The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016) |
| "Primary myelofibrosis was diagnosed because of bone marrow fibrosis and extramedullary hematopoiesis of the spleen." | 5.29 | [Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine]. ( Kawamura, Y; Niki, T, 1995) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy." | 3.83 | The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016) |
| " Compared to controls, cases were higher in body mass index, anti-dsDNA antibody, prevalence of hypertension, antiphospholipid syndrome, and use of immunosuppressive medication, especially azathioprine and methotrexate; they were lower in IgM." | 3.78 | Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus. ( Aghdassi, E; Fortin, PR; Gladman, DD; Hirschfield, GM; Huang, D; Mosko, J; Su, J; Urowitz, MB, 2012) |
| "Relapsing polychondritis is a rare immune-mediated condition, characterized by episodic inflammation of the cartilaginous tissue, in particular the ears, nose, and eyes, and involvement of joints and respiratory tract." | 2.49 | Unusual association between Budd-Chiari syndrome secondary to antiphospholipid syndrome and relapsing polychondritis: a case report and review of the literature. ( Campomori, F; Ferri, C; Giuggioli, D; Giuggoli, D; Manzini, CU; Schepis, F; Sebastiani, M; Spinella, A; Vacchi, C, 2013) |
| "Optic neuropathy is a well-known ocular manifestation occurring in patients with systemic lupus erythematosus (SLE), and it remains one of the major causes of blindness in these patients." | 2.40 | Optic neuropathy in systemic lupus erythematosus and antiphospholipid syndrome (APS): clinical features, pathogenesis, review of the literature and proposed ophthalmological criteria for APS diagnosis. ( Balacco Gabrieli, C; Giorgi, D, 1999) |
| "In two patients with primary antiphospholipid antibody syndrome and acute cerebrovascular ischemic events, local intraarterial fibrinolysis and intravenous heparin therapy, respectively, resulted in a limitation of persisting neurological deficits." | 2.38 | Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options. ( Braune, S; Lücking, CH; Siekmann, R; Vaith, P, 1993) |
| "Neuromyelitis optica (NMO or Devic's syndrome) is a rare autoimmune disease, previously considered a multiple sclerosis variant." | 1.36 | Devic's syndrome and primary APS: a new immunological overlap. ( Colagrande, S; Emmi, L; Squatrito, D, 2010) |
| "Primary Antiphospholipid Antibody Syndrome (PAPS) and Autoimmune haemolytic anemia (AIHA) is a very rare combination." | 1.35 | Primary antiphospholipid antibody syndrome and autoimmune haemolytic anaemia--a rare combination. ( Baig, MS; Humail, SM; Riaz, A; Suhail, S, 2009) |
| "However, bleeding is rare in this syndrome." | 1.35 | Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome. ( Abdallah, TB; Beji, S; El Younsi, F; Ezzine, S; Guermazi, S; Hamida, FB; Kaaroud, H; Kheder, A; Moussa, FB, 2008) |
| "Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare disorder characterized by a bleeding tendency due to factor II deficiency associated with the presence of lupus anticoagulant (LAC) autoantibodies." | 1.33 | Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome. ( Rich, E; Senécal, JL; Vinet, E, 2006) |
| "Life threatening cardiac arrhythmia was the first clinical manifestation of the disease." | 1.33 | [Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome]. ( Laskowska, K; Majdan, M; Suszek, D; Targońska-Stepniak, B, 2006) |
| "The diagnostic criteria for systemic lupus erythematosus (SLE) were not fulfilled either." | 1.32 | Late puerperal thrombohemorrhagic complications in a patient with antiphospholipid syndrome. ( Bladt, V; d'Amore, F; Laursen, B; Petersen, OB; Poulsen, LH; Steengaard-Pedersen, K, 2004) |
| "A diagnosis of mixed connective tissue disease (Sharp-syndrome) was established." | 1.30 | [A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome]. ( Hartmann, F; Kranzhöfer, N; Lindemuth, R; Zuber, M, 1998) |
| "Primary myelofibrosis was diagnosed because of bone marrow fibrosis and extramedullary hematopoiesis of the spleen." | 1.29 | [Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine]. ( Kawamura, Y; Niki, T, 1995) |
| " Moreover, progressive renal insufficiency can develop as a result of the long-term use of this drug." | 1.29 | Immunosuppressive treatment in a heart transplantation candidate with antiphospholipid syndrome. ( Agostini, C; Biasiolo, A; De Silvestro, G; Livi, U; Marson, P; Pengo, V, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 9 (31.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sebastiani, M | 1 |
| Manzini, CU | 1 |
| Campomori, F | 1 |
| Spinella, A | 1 |
| Vacchi, C | 1 |
| Giuggioli, D | 1 |
| Giuggoli, D | 1 |
| Schepis, F | 1 |
| Ferri, C | 1 |
| Yachoui, R | 1 |
| Sehgal, R | 1 |
| Amlani, B | 1 |
| Goldberg, JW | 1 |
| Sciascia, S | 1 |
| Hunt, BJ | 1 |
| Talavera-Garcia, E | 1 |
| Lliso, G | 1 |
| Khamashta, MA | 1 |
| Cuadrado, MJ | 1 |
| Korkmaz, C | 2 |
| Suhail, S | 1 |
| Baig, MS | 1 |
| Humail, SM | 1 |
| Riaz, A | 1 |
| Tarner, IH | 1 |
| Lange, U | 1 |
| Madlener, K | 1 |
| Classen, K | 1 |
| Kandolf, R | 1 |
| Sperzel, J | 1 |
| Müller-Ladner, U | 1 |
| Squatrito, D | 1 |
| Colagrande, S | 1 |
| Emmi, L | 1 |
| Prado, DM | 1 |
| Gualano, B | 1 |
| Pinto, AL | 1 |
| Sallum, AM | 1 |
| Perondi, MB | 1 |
| Roschel, H | 1 |
| Silva, CA | 1 |
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Huang, D | 1 |
| Aghdassi, E | 1 |
| Su, J | 1 |
| Mosko, J | 1 |
| Hirschfield, GM | 1 |
| Gladman, DD | 1 |
| Urowitz, MB | 1 |
| Fortin, PR | 1 |
| Noaiseh, G | 1 |
| Bhangle, S | 1 |
| Vivino, F | 1 |
| Kabukcuoğlu, S | 1 |
| Isiksoy, S | 1 |
| Yalçin, AU | 1 |
| Hadjigogos, K | 1 |
| Marinaki, P | 1 |
| Bladt, V | 1 |
| Steengaard-Pedersen, K | 1 |
| Poulsen, LH | 1 |
| Petersen, OB | 1 |
| Laursen, B | 1 |
| d'Amore, F | 1 |
| Chen, HC | 1 |
| Lai, JH | 1 |
| Huang, GS | 1 |
| Gao, HW | 1 |
| Chen, CH | 1 |
| Kuo, SY | 1 |
| Chang, DM | 1 |
| Foster, R | 1 |
| Rosenthal, E | 1 |
| Marques, S | 1 |
| Vounotrypidis, P | 1 |
| Sangle, S | 1 |
| D'Cruz, D | 1 |
| Vinet, E | 1 |
| Rich, E | 1 |
| Senécal, JL | 1 |
| Patterson, SL | 1 |
| LaMonte, MP | 1 |
| Mikdashi, JA | 1 |
| Haines, ST | 1 |
| Hursting, MJ | 1 |
| Targońska-Stepniak, B | 1 |
| Majdan, M | 1 |
| Suszek, D | 1 |
| Laskowska, K | 1 |
| Kaaroud, H | 1 |
| Beji, S | 1 |
| Guermazi, S | 1 |
| Moussa, FB | 1 |
| Hamida, FB | 1 |
| Ezzine, S | 1 |
| Abdallah, TB | 1 |
| El Younsi, F | 1 |
| Kheder, A | 1 |
| Niki, T | 1 |
| Kawamura, Y | 1 |
| Bühler-Singer, S | 1 |
| von Hintzenstern, J | 1 |
| Fartasch, M | 1 |
| Hornstein, OP | 1 |
| Braune, S | 1 |
| Siekmann, R | 1 |
| Vaith, P | 1 |
| Lücking, CH | 1 |
| Pengo, V | 1 |
| Biasiolo, A | 1 |
| Marson, P | 1 |
| De Silvestro, G | 1 |
| Agostini, C | 1 |
| Livi, U | 1 |
| Cockwell, P | 1 |
| Zuber, M | 1 |
| Kranzhöfer, N | 1 |
| Lindemuth, R | 1 |
| Hartmann, F | 1 |
| Giorgi, D | 1 |
| Balacco Gabrieli, C | 1 |
| Stratta, P | 1 |
| Canavese, C | 1 |
| Santi, S | 1 |
| Ciccone, G | 1 |
| Rosso, S | 1 |
| Salim, S | 1 |
| Salim, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-blind, Randomized and Parallel Controlled Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Miscarriage With Antiphospholipid Syndrome[NCT04624269] | Phase 4 | 384 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | ||
| A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174] | 420 participants (Anticipated) | Interventional | 2019-08-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for azathioprine and Anti-Phospholipid Antibody Syndrome
| Article | Year |
|---|---|
Unusual association between Budd-Chiari syndrome secondary to antiphospholipid syndrome and relapsing polychondritis: a case report and review of the literature.
Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Budd-Chiari Syndrome; Comorbi | 2013 |
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Anticoagulants; Antiphospholipid Syndrome; An | 2005 |
Primary systemic vasculitis: treatment of difficult cases.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antiphospholipid; Antibodies, Monoclonal; Antibo | 2006 |
Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature.
Topics: Anticoagulants; Antiphospholipid Syndrome; Arginine; Azathioprine; Brain Ischemia; Dexamethasone; Hu | 2006 |
Primary antiphospholipid antibody syndrome and cerebral ischemia: report on acute intervention in two cases and literature review with emphasis on therapeutic options.
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Brain Ischemia; Cyclophosphamide; Enzyme-Linked Immu | 1993 |
Optic neuropathy in systemic lupus erythematosus and antiphospholipid syndrome (APS): clinical features, pathogenesis, review of the literature and proposed ophthalmological criteria for APS diagnosis.
Topics: Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprin | 1999 |
22 other studies available for azathioprine and Anti-Phospholipid Antibody Syndrome
| Article | Year |
|---|---|
Antiphospholipid antibodies-associated diffuse alveolar hemorrhage.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azath | 2015 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; | 2016 |
Do immunosuppressives upregulate antiphospholid antibodies?
Topics: Antiphospholipid Syndrome; Autoantibodies; Autoimmune Diseases; Azathioprine; Biomarkers; Cardiolipi | 2009 |
Primary antiphospholipid antibody syndrome and autoimmune haemolytic anaemia--a rare combination.
Topics: Adolescent; Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Anticoagulants; Antiphospholipid | 2009 |
[A wolf in sheep's clothing: atypical systemic lupus erythematosus (SLE) presenting as cardiovascular disease].
Topics: Antiphospholipid Syndrome; Azathioprine; Biopsy; Diagnosis, Differential; Female; Heart Failure; Hea | 2010 |
Devic's syndrome and primary APS: a new immunological overlap.
Topics: Antiphospholipid Syndrome; Azathioprine; Humans; Immunosuppressive Agents; Magnetic Resonance Imagin | 2010 |
Exercise in a child with systemic lupus erythematosus and antiphospholipid syndrome.
Topics: Adolescent; Anaerobic Threshold; Antiphospholipid Syndrome; Azathioprine; Drug Therapy, Combination; | 2011 |
Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus.
Topics: Adult; Alanine Transaminase; Antibodies, Neutralizing; Antiphospholipid Syndrome; Aspartate Aminotra | 2012 |
Idiopathic mediastinal fibrosis presenting with antiphospholipid antibody syndrome and manifestations suggestive of connective tissue disease.
Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Antirheumatic Agents; Azathioprine; Connecti | 2012 |
Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy.
Topics: Adult; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Female; Glomeruloscler | 2003 |
Autoimmune hepatitis and the antiphospholipid antibody syndrome. A case report.
Topics: Adult; Antiphospholipid Syndrome; Aspirin; Azathioprine; Female; Hepatitis, Autoimmune; Humans; Pred | 2003 |
Late puerperal thrombohemorrhagic complications in a patient with antiphospholipid syndrome.
Topics: Abortion, Habitual; Activated Protein C Resistance; Adult; Anticoagulants; Antiphospholipid Syndrome | 2004 |
Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome.
Topics: Adrenal Cortex Hormones; Antiphospholipid Syndrome; Azathioprine; Central Nervous System Diseases; C | 2006 |
[Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome].
Topics: Adult; Antibodies, Antinuclear; Antiphospholipid Syndrome; Arrhythmias, Cardiac; Autoantibodies; Aut | 2006 |
Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome.
Topics: Adrenal Cortex Hormones; Adult; Anticoagulants; Antiphospholipid Syndrome; Azathioprine; Female; Hem | 2008 |
[Hematological remission of primary myelofibrosis with antiphospholipid antibody following treatment of azathioprine].
Topics: Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azathioprine; Female; Humans; Middle Aged; | 1995 |
[Anticardiolipin syndrome with only skin involvement].
Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Arm; Aspirin; Azathioprine; Combined | 1994 |
Immunosuppressive treatment in a heart transplantation candidate with antiphospholipid syndrome.
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Cardiomyopathy, Dilated; Cyclosporine; Drug Therapy, | 1996 |
Systemic lupus erythematosus [clinical inference].
Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Cyclophosphamide; Female; Humans; Lupus Erythematosu | 1997 |
[A patient with mixed collagen disease, antiphospholipid syndrome and Sjögren syndrome].
Topics: Adult; Antiphospholipid Syndrome; Aspirin; Azathioprine; Biopsy; Diagnosis, Differential; Drug Thera | 1998 |
Systemic lupus erythematosus.
Topics: Antiphospholipid Syndrome; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Humans; Immunogl | 2001 |
Antiphospholipid antibody syndrome of systemic lupus erythematosus presenting as deep vein thrombosis.
Topics: Adolescent; Adrenal Cortex Hormones; Anticoagulants; Antiphospholipid Syndrome; Azathioprine; Female | 1992 |