Compounds > azathioprine
Page last updated: 2024-10-23

azathioprine and Anal Fistula

azathioprine has been researched along with Anal Fistula in 23 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease."9.10Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003)
"Our aim was to report the clinical experience with combination treatment using tacrolimus and either azathioprine (AZA) or 6-mercaptopurine (6MP) in patients with Crohn's disease (CD) perianal fistulae."9.09Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. ( Lowry, PW; Sandborn, WJ; Tremaine, WJ; Weaver, AL, 1999)
"To evaluate combination therapy with azathioprine and metronidazole in German Shepherd Dogs with perianal fistulae."7.70Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery. ( Beck, JA; Hunt, GB; Malik, R; Tisdall, PL, 1999)
"The combination of cyclosporine, azathioprine and low-dose prednisolone leads to marked improvement of perianal fistulas in Crohn's disease."7.69Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease. ( Aichbichler, B; Fickert, P; Hinterleitner, TA; Krejs, GJ; Petritsch, W; Ranner, G, 1997)
"To evaluate, in a prospective, open-label study, the influence of antibiotics and azathioprine on the clinical outcome of perianal fistulas in patients with Crohn's disease."5.10Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. ( Dejaco, C; Harrer, M; Miehsler, W; Reinisch, W; Vogelsang, H; Waldhoer, T, 2003)
"Our aim was to report the clinical experience with combination treatment using tacrolimus and either azathioprine (AZA) or 6-mercaptopurine (6MP) in patients with Crohn's disease (CD) perianal fistulae."5.09Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. ( Lowry, PW; Sandborn, WJ; Tremaine, WJ; Weaver, AL, 1999)
"To evaluate combination therapy with azathioprine and metronidazole in German Shepherd Dogs with perianal fistulae."3.70Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery. ( Beck, JA; Hunt, GB; Malik, R; Tisdall, PL, 1999)
"The combination of cyclosporine, azathioprine and low-dose prednisolone leads to marked improvement of perianal fistulas in Crohn's disease."3.69Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease. ( Aichbichler, B; Fickert, P; Hinterleitner, TA; Krejs, GJ; Petritsch, W; Ranner, G, 1997)
"Complex perianal fistulas have a negative impact on the quality of life of sufferers and should be treated."2.45Emerging treatments for complex perianal fistula in Crohn's disease. ( García-Olmo, D; Schwartz, DA; Taxonera, C, 2009)
"Fistulas are common in patients with Crohn's disease and, when associated with inflammatory disease and established for several weeks, tend to be chronic."2.41Management of fistulas in patients with Crohn's disease: antibiotic to antibody. ( Paré, P, 2001)
"Treatment with azathioprine had a negative impact on recurrence rates."1.91[Effectiveness of Mucosal Advancement Flaps in Surgery of Perianal Fistulas from Crohn´s Disease and Cryptoglandular Fistulas - a Long-term Follow-up Study]. ( Bruder, L; Kamphues, C; Kreis, M; Lauscher, JC; Schineis, C; Warschkow, R; Weixler, B, 2023)
"Perianal fistulas are the most common and frequently encountered types of fistulas in Crohn's disease (CD)."1.40[Combination biological therapy for fistular Crohn's disease: clinical demonstration]. ( Knyazev, OV; Konoplyannikov, AG; Lischchinskaya, AA; Parfenov, AI; Ruchkina, IN; Shcherbakov, PL, 2014)
"Appropriate treatment of perianal fistulas in Crohn's disease (CD) involves accurate anatomic evaluation."1.38Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy. ( Assulin, Y; Beer-Gabel, M; Chowers, Y; Lahat, A, 2012)
"Recto-urethral fistulas due to Crohn's disease are very uncommon."1.35[Urethral fistula due to Crohn's disease: case report of successful conservative management]. ( Borovicka, J; Engeler, DS; Hetzer, FH; Meyer, D; Schmid, HP; Schwab, C, 2008)
"In persistent complex perianal fistulae where medical treatment initially fails, examination under anaesthesia and placement of non-cutting setons, when necessary, combined with medical treatment results in higher healing rates."1.34The patient with persistent perianal fistulae. ( Koutroubakis, IE, 2007)
"The purine analogues 6-mercaptopurine (6-MP) and azathioprine have been found to be safe and efficacious in both inducing remission of Crohn's disease in adults and maintaining remission in adults and children."1.32Therapeutic efficacy and safety of 6-mercaptopurine and azathioprine in patients with Crohn's disease. ( Markowitz, JF, 2003)
"Metastatic Crohn's disease is a term used to describe a granulomatous reaction occurring in flexures, and separated from the affected areas of the gastro-intestinal tract by normal skin."1.26Metastatic Crohn's disease. ( Gray, WM; McCallum, DI, 1976)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's4 (17.39)18.2507
2000's10 (43.48)29.6817
2010's5 (21.74)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Schineis, C1
Warschkow, R1
Bruder, L1
Lauscher, JC1
Kamphues, C1
Kreis, M1
Weixler, B1
Sosa Solís, AM1
Fernández Antuña, L1
Royo Cuadra, Y1
Castellarnau Figueras, E1
Knyazev, OV1
Parfenov, AI1
Shcherbakov, PL1
Konoplyannikov, AG1
Ruchkina, IN1
Lischchinskaya, AA1
Matnani, R1
Peker, D1
Iesalnieks, I1
Glass, H1
Kilger, A1
Ott, C1
Klebl, F1
Agha, A1
Schlitt, HJ1
Strauch, U1
Taxonera, C1
Schwartz, DA1
García-Olmo, D1
Alvarez, JA1
Bermejo, F1
Algaba, A1
Hernandez, MP1
Grau, M1
Lahat, A1
Assulin, Y1
Beer-Gabel, M1
Chowers, Y1
Buhr, HJ1
Kroesen, AJ1
Stange, EF1
Markowitz, JF1
Lecomte, T1
Contou, JF1
Beaugerie, L1
Carbonnel, F1
Cattan, S1
Gendre, JP1
Cosnes, J1
Dejaco, C1
Harrer, M1
Waldhoer, T1
Miehsler, W1
Vogelsang, H1
Reinisch, W1
Koutroubakis, IE1
Rodríguez-Moranta, F1
Soriano-Izquierdo, A1
Guardiola, J1
Schwab, C1
Meyer, D1
Hetzer, FH1
Borovicka, J1
Schmid, HP1
Engeler, DS1
Hinterleitner, TA1
Petritsch, W1
Aichbichler, B1
Fickert, P1
Ranner, G1
Krejs, GJ1
Lehrnbecher, T1
Kontny, HU1
Jeschke, R1
Lowry, PW1
Weaver, AL1
Tremaine, WJ1
Sandborn, WJ1
Tisdall, PL1
Hunt, GB1
Beck, JA1
Malik, R1
Paré, P1
McCallum, DI1
Gray, WM1
Brown, CH1
Achkar, E1
Tozer, P1
Ng, SC1
Siddiqui, MR1
Plamondon, S1
Burling, D1
Gupta, A1
Swatton, A1
Tripoli, S1
Vaizey, CJ1
Kamm, MA1
Phillips, R1
Hart, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment of Fistulous Crohn's Disease by Implant of Autologous Mesenchymal Stem Cells Derived From Adipose Tissue[NCT01157650]Phase 1/Phase 215 participants (Actual)Interventional2010-06-30Completed
A Prospective Longitudinal Study on the Effect of Tight Control Management on Perianal Crohn's Disease[NCT03861689]40 participants (Anticipated)Interventional2019-07-01Enrolling by invitation
Stopping Biological Therapy in Perianal Crohn's Disease Patients With Radiologically Healed Fistulas: a Prospective Cohort Study[NCT04129723]0 participants (Actual)Interventional2022-01-01Withdrawn (stopped due to No suitable case identified)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for azathioprine and Anal Fistula

ArticleYear
Emerging treatments for complex perianal fistula in Crohn's disease.
    World journal of gastroenterology, 2009, Sep-14, Volume: 15, Issue:34

    Topics: Anti-Bacterial Agents; Azathioprine; Crohn Disease; Humans; Immunologic Factors; Mercaptopurine; Rec

2009
[Current status of treatment of inflammatory bowel disease].
    Cirugia espanola, 2007, Volume: 82, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, H

2007
Management of fistulas in patients with Crohn's disease: antibiotic to antibody.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2001, Volume: 15, Issue:11

    Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Azathioprine; Colonic Diseases; Crohn Disease; Cyclos

2001

Trials

2 trials available for azathioprine and Anal Fistula

ArticleYear
Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease.
    Alimentary pharmacology & therapeutics, 2003, Volume: 18, Issue:11-12

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anus Diseases; Azathioprine;

2003
Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae.
    Inflammatory bowel diseases, 1999, Volume: 5, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Azathioprine; Crohn Disease; Drug Therapy, Combination; Fem

1999

Other Studies

18 other studies available for azathioprine and Anal Fistula

ArticleYear
[Effectiveness of Mucosal Advancement Flaps in Surgery of Perianal Fistulas from Crohn´s Disease and Cryptoglandular Fistulas - a Long-term Follow-up Study].
    Zentralblatt fur Chirurgie, 2023, Volume: 148, Issue:3

    Topics: Azathioprine; Crohn Disease; Follow-Up Studies; Humans; Rectal Fistula; Retrospective Studies; Treat

2023
Perianal disease as the first manifestation in paediatric Crohn's disease.
    Gastroenterologia y hepatologia, 2020, Volume: 43, Issue:5

    Topics: Abscess; Adalimumab; Anemia, Hypochromic; Azathioprine; Child; Crohn Disease; Fissure in Ano; Gastro

2020
[Combination biological therapy for fistular Crohn's disease: clinical demonstration].
    Terapevticheskii arkhiv, 2014, Volume: 86, Issue:2

    Topics: Adult; Antibodies, Monoclonal; Azathioprine; Combined Modality Therapy; Crohn Disease; Drug Therapy,

2014
Azathioprine induced Epstein Barr virus-positive mucocutaneous ulcer arising in perianal fistula and abscess associated with Crohn's disease.
    Journal of Crohn's & colitis, 2014, Volume: 8, Issue:12

    Topics: Abscess; Anus Diseases; Azathioprine; Crohn Disease; Herpesvirus 4, Human; Humans; Immunosuppressive

2014
[Perianal fistulas in Crohn's disease: treatment results at an interdisciplinary unit].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2009, Volume: 80, Issue:6

    Topics: Abscess; Adolescent; Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal;

2009
Surgical repair and biological therapy for fecal incontinence in Crohn's disease involving both sphincter defects and complex fistulas.
    Journal of Crohn's & colitis, 2011, Volume: 5, Issue:6

    Topics: Abscess; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Anus Diseases; Azathioprine; Crohn

2011
Endoscopic ultrasound for perianal Crohn's disease: disease and fistula characteristics, and impact on therapy.
    Journal of Crohn's & colitis, 2012, Volume: 6, Issue:3

    Topics: Abscess; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Infective Agents; Anti-Inflammatory

2012
[Surgery -- fistulas].
    Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:1

    Topics: Abdominal Abscess; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antibodies, Monoclonal; Azathiopr

2003
Therapeutic efficacy and safety of 6-mercaptopurine and azathioprine in patients with Crohn's disease.
    Reviews in gastroenterological disorders, 2003, Volume: 3 Suppl 1

    Topics: Adjuvants, Immunologic; Adult; Azathioprine; Child; Crohn Disease; Humans; Immunosuppressive Agents;

2003
Predictive factors of response of perianal Crohn's disease to azathioprine or 6-mercaptopurine.
    Diseases of the colon and rectum, 2003, Volume: 46, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anus Diseases; Azathioprine; Confidence Intervals; Crohn

2003
The patient with persistent perianal fistulae.
    Best practice & research. Clinical gastroenterology, 2007, Volume: 21, Issue:3

    Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Azathioprine; Cyclosporine; Humans; Infliximab; Magne

2007
[Urethral fistula due to Crohn's disease: case report of successful conservative management].
    Der Urologe. Ausg. A, 2008, Volume: 47, Issue:10

    Topics: Azathioprine; Ciprofloxacin; Crohn Disease; Cystoscopy; Cystostomy; Diagnosis, Differential; Drug Th

2008
Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn's disease.
    Zeitschrift fur Gastroenterologie, 1997, Volume: 35, Issue:8

    Topics: Adult; Azathioprine; Crohn Disease; Cyclosporine; Dose-Response Relationship, Drug; Drug Administrat

1997
Metastatic Crohn's disease in a 9-year-old boy.
    Journal of pediatric gastroenterology and nutrition, 1999, Volume: 28, Issue:3

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Azathioprine; Child; Crohn Disease; Erythema; Human

1999
Management of perianal fistulae in five dogs using azathioprine and metronidazole prior to surgery.
    Australian veterinary journal, 1999, Volume: 77, Issue:6

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Azathioprine; Dog Diseases; Dogs; Female; Immu

1999
Metastatic Crohn's disease.
    The British journal of dermatology, 1976, Volume: 95, Issue:5

    Topics: Adult; Azathioprine; Biopsy; Crohn Disease; Ear, External; Humans; Male; Rectal Fistula; Skin Diseas

1976
Azathioprine therapy for inflammatory bowel disease. A preliminary report.
    The American journal of gastroenterology, 1970, Volume: 54, Issue:4

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chronic Disease; Colitis, Ulcerative;

1970
Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn's perianal fistulas.
    Inflammatory bowel diseases, 2012, Volume: 18, Issue:10

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humaniz

2012
Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn's perianal fistulas.
    Inflammatory bowel diseases, 2012, Volume: 18, Issue:10

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humaniz

2012
Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn's perianal fistulas.
    Inflammatory bowel diseases, 2012, Volume: 18, Issue:10

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humaniz

2012
Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn's perianal fistulas.
    Inflammatory bowel diseases, 2012, Volume: 18, Issue:10

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humaniz

2012