azathioprine has been researched along with Amyotrophic Lateral Sclerosis in 7 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient." | 7.81 | Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. ( Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M, 2015) |
| "We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient." | 3.81 | Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. ( Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Salvado, M | 1 |
| Vargas, V | 1 |
| Vidal, M | 1 |
| Simon-Talero, M | 1 |
| Camacho, J | 1 |
| Gamez, J | 1 |
| Bentes, C | 1 |
| de Carvalho, M | 1 |
| Valente, I | 1 |
| Sales Luis, ML | 1 |
| da Silva, JP | 1 |
| Jerusalem, F | 1 |
| Overgaard, K | 1 |
| Werdelin, L | 2 |
| Sørensen, H | 1 |
| Mogensen, P | 2 |
| Boysen, G | 2 |
| Jensen, TS | 1 |
| Conradi, S | 1 |
| Ronnevi, LO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amyotrophic Lateral Sclerosis and the Innate Immune System[NCT02869048] | 375 participants (Anticipated) | Observational | 2016-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for azathioprine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
[Treatment of myopathies and spinal muscular atrophies (author's transl)].
Topics: Amyotrophic Lateral Sclerosis; Azathioprine; Collagen Diseases; Dermatomyositis; Glycogen Storage Di | 1978 |
6 other studies available for azathioprine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
ALSUntangled 58: Azathioprine.
Topics: Amyotrophic Lateral Sclerosis; Azathioprine; Humans | 2021 |
Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient.
Topics: Adult; Amyotrophic Lateral Sclerosis; Azathioprine; Benzamides; Biopsy; Chemical and Drug Induced Li | 2015 |
Amyotrophic lateral sclerosis syndrome associated with connective tissue disease; improvement after immunosuppressive therapy. A long-term follow-up case.
Topics: Amyotrophic Lateral Sclerosis; Anti-Inflammatory Agents; Azathioprine; Connective Tissue Diseases; F | 1999 |
Cytotoxic activity in plasma from patients with amyotrophic lateral sclerosis.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Azathioprine; Female; Hemolysis; Humans; Mal | 1991 |
Immunosuppressive treatment of patients with amyotrophic lateral sclerosis.
Topics: Administration, Oral; Adult; Aged; Amyotrophic Lateral Sclerosis; Azathioprine; Female; Humans; Infu | 1990 |
Effect of immunosuppression on cytotoxic activity in amyotrophic lateral sclerosis.
Topics: Aged; Amyotrophic Lateral Sclerosis; Azathioprine; Cytotoxicity, Immunologic; Drug Therapy, Combinat | 1987 |