Page last updated: 2024-10-23

azathioprine and Amyloidosis

azathioprine has been researched along with Amyloidosis in 32 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

Research Excerpts

ExcerptRelevanceReference
" This case report describes a patient with RA complicated by amyloidosis and the nephrotic syndrome, which regressed after treatment with azathioprine."8.79Regression of the nephrotic syndrome in rheumatoid arthritis and amyloidosis treated with azathioprine. A case report. ( Shapiro, DL; Spiera, H, 1995)
"Treatment with azathioprine in addition to colchicine could ameliorate the nephrotic syndrome and control the attacks very effectively in these cases."5.33Successful treatment of nephrotic syndrome due to FMF amyloidosis with azathioprine: report of three Turkish cases. ( Dogan, E; Erkoc, R; Sayarlioglu, H; Sayarlioglu, M; Soyoral, Y, 2006)
" This case report describes a patient with RA complicated by amyloidosis and the nephrotic syndrome, which regressed after treatment with azathioprine."4.79Regression of the nephrotic syndrome in rheumatoid arthritis and amyloidosis treated with azathioprine. A case report. ( Shapiro, DL; Spiera, H, 1995)
" Though a definitive therapeutic strategy has not been established for localized gastrointestinal amyloidosis, the patient has been successfully treated with a high-dose of steroids and azathioprine."3.78[A case of primary colon amyloidosis presenting as hematochezia]. ( Jeon, SW; Kim, JH; Kim, JY; Kim, SK; Kwon, YH; Park, HW; Yang, HM, 2012)
" The younger patient had the diagnosis confirmed at an early stage by renal biopsy, and under heparin and azathioprine the clinical signs, especially the nephrotic syndrome, regressed over a period of seven months."3.65[Amyloidosis in familial mediterranean fever: clinical and renal-biopsy features (author's transl)]. ( Angelkort, B; Brass, H; Buss, H; Heintz, R; Klein, H; Lapp, H, 1976)
"Azathioprine is a useful drug in severe JCA, with a sustained effect and acceptable side effects."2.68Azathioprine in patients with juvenile chronic arthritis: a longterm followup study. ( Aho, K; Isomäki, H; Kautiainen, H; Savolainen, HA; Verronen, P, 1997)
"Treatment with azathioprine in addition to colchicine could ameliorate the nephrotic syndrome and control the attacks very effectively in these cases."1.33Successful treatment of nephrotic syndrome due to FMF amyloidosis with azathioprine: report of three Turkish cases. ( Dogan, E; Erkoc, R; Sayarlioglu, H; Sayarlioglu, M; Soyoral, Y, 2006)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199019 (59.38)18.7374
1990's6 (18.75)18.2507
2000's2 (6.25)29.6817
2010's5 (15.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fix, OK1
Stock, PG1
Lee, BK1
Benson, MD1
Sargin, G1
Senturk, T1
Cildag, S1
Rodrigues, K1
Neves, FS1
Stoeterau, KB1
Werner Castro, GR1
Nobre, LF1
Zimmermann, AF1
Pereira, IA1
Wey, SJ1
Chen, YM1
Lai, PJ1
Chen, DY1
Cabezuelo, JB1
Egea, JP1
Ramos, F1
Torrella, E1
Muray, S1
Alcázar, C1
Sayarlioglu, H1
Erkoc, R1
Sayarlioglu, M1
Dogan, E1
Soyoral, Y1
Walford, RL1
Plamieniak, Z1
Zareba-Bogdał, E1
Bednorz, W1
Shapiro, DL1
Spiera, H1
Kullmann, F1
Kullmann, M1
Leser, HG1
Krämer, BK1
Riegger, AJ1
Schölmerich, J1
Moroni, G1
Banfi, G1
Maccario, M1
Mereghetti, M1
Ponticelli, C1
Savolainen, HA1
Kautiainen, H1
Isomäki, H1
Aho, K1
Verronen, P1
Glasbrenner, B1
Güthner, C1
Röcken, C1
Mattfeld, T1
Hetzel, W1
Adler, G1
Kasper, H1
Missmahl, HP1
Willemsen, M1
Brass, H1
Klein, H1
Buss, H1
Lapp, H1
Heintz, R1
Angelkort, B1
Yussim, A1
Sosna, Y1
Shapira, Z1
Niska, A1
Pras, M1
Steinhoff, J1
Schulz, E1
Herbst, EW1
Fricke, L1
Sack, K1
Ollague, W1
Ahlmen, M1
Ahlmen, J1
Svalander, C1
Bucht, H1
Hardt, F1
Cohen, AS1
Bricetti, AB1
Harrington, JT1
Mannick, JA1
Matthews, RJ1
Orlowski, T1
Wojtulewicz-Kurkus, J1
Glyda, J1
Kunert, Z1
Arustamova, RG1
Serov, VV2
Mukhin, NA2
Drozd, TN1
Berezina, TA1
Kampf, D1
Baethke, R1
Sura, VV1
Chebyshev, AP1
Gritsman, AIu1
Kölle, G1
Stoeber, E1
Schöntag, W1
Brys, R1
Ringoir, S1
Elewaut, A1
Barbier, F1
Schulz, HJ1
Reitzig, P1
Lisewski, G1
Dietze, F1
Mamou, H1
Kwon, YH1
Kim, JY1
Kim, JH1
Park, HW1
Yang, HM1
Jeon, SW1
Kim, SK1

Reviews

3 reviews available for azathioprine and Amyloidosis

ArticleYear
Regression of the nephrotic syndrome in rheumatoid arthritis and amyloidosis treated with azathioprine. A case report.
    Arthritis and rheumatism, 1995, Volume: 38, Issue:12

    Topics: Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Middle Aged;

1995
[Therapy of glomerulonephritis with corticosteroids and immunosuppressive agents].
    Deutsche medizinische Wochenschrift (1946), 1974, May-24, Volume: 99, Issue:21

    Topics: Adrenal Cortex Hormones; Adult; Amyloidosis; Azathioprine; Child; Cyclophosphamide; Diabetic Nephrop

1974
[Morphogenetic bases of an experimental therapy for amyloidosis].
    Arkhiv patologii, 1974, Volume: 36, Issue:10

    Topics: Absorption; Amyloid; Amyloidosis; Animals; Antilymphocyte Serum; Antimetabolites; Azathioprine; Fibr

1974

Trials

3 trials available for azathioprine and Amyloidosis

ArticleYear
Azathioprine in patients with juvenile chronic arthritis: a longterm followup study.
    The Journal of rheumatology, 1997, Volume: 24, Issue:12

    Topics: Adolescent; Amyloidosis; Antirheumatic Agents; Arthritis, Juvenile; Azathioprine; Child; Chronic Dis

1997
Primary cutaneous amyloidosis.
    International journal of dermatology, 1987, Volume: 26, Issue:2

    Topics: Administration, Topical; Amyloidosis; Azathioprine; Clinical Trials as Topic; Colchicine; Dimethyl S

1987
Cytotoxic drug treatment of reactive amyloidosis in rheumatoid arthritis with special reference to renal insufficiency.
    Clinical rheumatology, 1987, Volume: 6, Issue:1

    Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Femal

1987

Other Studies

26 other studies available for azathioprine and Amyloidosis

ArticleYear
Liver transplant alone without kidney transplant for fibrinogen Aα-chain (AFib) renal amyloidosis.
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2016, Volume: 23, Issue:2

    Topics: Amyloidosis; Azathioprine; Creatinine; Female; Fibrinogen; Gene Expression; Genes, Dominant; Graft v

2016
Effective treatment with azathioprine for renal amyloidosis secondary to familial Mediterranean fever.
    Scandinavian journal of rheumatology, 2016, Volume: 45, Issue:4

    Topics: Adult; Amyloidosis; Azathioprine; Blood Sedimentation; C-Reactive Protein; Creatinine; Familial Medi

2016
Pulmonary amyloidosis in Sjögren's syndrome: a rare diagnosis for nodular lung lesions.
    International journal of rheumatic diseases, 2009, Volume: 12, Issue:4

    Topics: Amyloid; Amyloidosis; Antirheumatic Agents; Azathioprine; Coloring Agents; Congo Red; Drug Therapy,

2009
Primary sjögren syndrome manifested as localized cutaneous nodular amyloidosis.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2011, Volume: 17, Issue:7

    Topics: Aged; Amyloidosis; Antirheumatic Agents; Azathioprine; Female; Humans; Hydroxychloroquine; Immunohis

2011
Infliximab in the treatment of amyloidosis secondary to Crohn's disease.
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, May-14, Volume: 32, Issue:3

    Topics: Adult; Amyloidosis; Antibodies, Monoclonal; Azathioprine; Crohn Disease; Deglutition Disorders; Drug

2012
Successful treatment of nephrotic syndrome due to FMF amyloidosis with azathioprine: report of three Turkish cases.
    Rheumatology international, 2006, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Amyloidosis; Antirheumatic Agents; Azathioprine; Colchicine; Drug Therapy, Combin

2006
The role of autoimmune phenomena in the ageing process.
    Symposia of the Society for Experimental Biology, 1967, Volume: 21

    Topics: Aging; Amyloidosis; Animals; Appendix; Autoantibodies; Azathioprine; Cricetinae; Fishes; Hemolysin P

1967
[Long-term remission after treatment of primary amyloidosis with azathioprine].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1980, Sep-08, Volume: 35, Issue:36

    Topics: Aged; Amyloidosis; Azathioprine; Humans; Male; Remission, Spontaneous; Time Factors

1980
[Nephrotic syndrome as the initial symptom of Crohn disease].
    Zeitschrift fur Gastroenterologie, 1996, Volume: 34, Issue:11

    Topics: Amyloidosis; Azathioprine; Biopsy; Cecum; Combined Modality Therapy; Crohn Disease; Humans; Immunosu

1996
Extracapillary glomerulonephritis and renal amyloidosis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 28, Issue:5

    Topics: Aged; Amyloidosis; Azathioprine; Biopsy; Cyclophosphamide; Female; Glomerulonephritis; Glucocorticoi

1996
[56-year-old patient with segmental florid colitis and colonic amyloidosis].
    Der Internist, 1999, Volume: 40, Issue:6

    Topics: Amyloidosis; Azathioprine; Colitis; Colonic Diseases; Colonoscopy; Crohn Disease; Diagnosis, Differe

1999
[Enteritis regionalis (Crohn's disease) (proceedings)].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1976, Issue:12

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Amyloidosis; Arthritis; Azathioprine; Child; Child

1976
[Therapy of amyloidoses].
    Deutsche medizinische Wochenschrift (1946), 1977, Nov-04, Volume: 102, Issue:44

    Topics: Amyloidosis; Azathioprine; Chlorambucil; Colchicine; Humans; Penicillamine

1977
[Amyloidosis in familial mediterranean fever: clinical and renal-biopsy features (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1976, Feb-06, Volume: 101, Issue:6

    Topics: Acute Kidney Injury; Adolescent; Adult; Amyloidosis; Azathioprine; Biopsy; Familial Mediterranean Fe

1976
Azathioprine enhances experimental amyloidosis and attenuates colchicine protection against organ deposition of amyloid.
    Transplantation proceedings, 1991, Volume: 23, Issue:4

    Topics: Amyloidosis; Animals; Azathioprine; Caseins; Colchicine; Mice; Spleen

1991
[Therapy of amyloid nephrosis in Crohn disease: plasmapheresis plus azathioprine?].
    Wiener medizinische Wochenschrift (1946), 1988, Feb-15, Volume: 138, Issue:3

    Topics: Adult; Amyloidosis; Azathioprine; Combined Modality Therapy; Crohn Disease; Female; Glomerular Mesan

1988
Acceleration of casein induced amyloidosis in mice by immunosuppressive agents.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1971, Volume: 79, Issue:1

    Topics: Amyloid; Amyloidosis; Animals; Azathioprine; Busulfan; Caseins; Chloramphenicol; Cortisone; Dactinom

1971
Renal transplantation in two cases of amyloidosis.
    Lancet (London, England), 1971, Sep-04, Volume: 2, Issue:7723

    Topics: Abscess; Adult; Age Factors; Amyloidosis; Antilymphocyte Serum; Autopsy; Azathioprine; Biopsy; Cadav

1971
Idiopathic autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura associated with diffuse hypergammaglobulinemia, amyloidosis, hypoalbuminemia and plasmacytosis.
    The American journal of medicine, 1965, Volume: 39, Issue:6

    Topics: Aged; Amyloidosis; Anemia, Hemolytic, Autoimmune; Azathioprine; Bence Jones Protein; Blood Protein D

1965
Immunosuppressive treatment of nephrotic syndrome.
    Polish medical journal, 1969, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Aged; Amyloidosis; Azathioprine; Biopsy; Blood Proteins; Chlorambucil; Dactinomyc

1969
Effect of imuran on the course of experimental amyloidosis.
    Bulletin of experimental biology and medicine, 1974, Volume: 77, Issue:2

    Topics: Amyloid; Amyloidosis; Animals; Antigens; Azathioprine; Blood Protein Disorders; Caseins; Disease Mod

1974
[Immunosuppressive agents in the basic therapy of visceral forms of rheumatoid arthritis in children].
    Medizinische Klinik, 1972, Apr-28, Volume: 67, Issue:17

    Topics: Adolescent; Adrenal Cortex Hormones; Amyloidosis; Arthritis, Juvenile; Arthritis, Rheumatoid; Azathi

1972
[Amyloidosis in Crohn's disease].
    Tijdschrift voor gastro-enterologie, 1972, Volume: 15, Issue:5

    Topics: Amyloidosis; Azathioprine; Crohn Disease; Humans; Male; Nephrotic Syndrome

1972
[Malabsorption syndrome and intestinal pseudoobstruction in primary vascular and heart amyloidosis].
    Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1973, Volume: 33, Issue:4

    Topics: Adult; Amyloidosis; Antibody Formation; Antigen-Antibody Complex; Azathioprine; Chloramphenicol; Cys

1973
[Current knowledge on periodic disease].
    La Presse medicale, 1970, Mar-28, Volume: 78, Issue:16

    Topics: Adrenal Cortex Hormones; Amyloidosis; Anti-Inflammatory Agents; Azathioprine; Busulfan; Ethnicity; F

1970
[A case of primary colon amyloidosis presenting as hematochezia].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012, Volume: 59, Issue:1

    Topics: Amyloidosis; Antimetabolites; Colon; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Immun

2012