azathioprine has been researched along with Amenorrhea in 7 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Amenorrhea: Absence of menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirty-eight patients with diffuse glomerulonephritis of systemic lupus erythematosus were randomly assigned to add cyclophosphamide, azathioprine, or nothing to low-dose corticosteroid treatment and have been followed for a mean of 21/3 years thereafter." | 9.04 | Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months. ( Decker, JL; Klippel, JH; Plotz, PH; Steinberg, AD, 1975) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 7.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "For patients with proliferative lupus nephritis, short-term therapy with intravenous cyclophosphamide followed by maintenance therapy with mycophenolate mofetil or azathioprine appears to be more efficacious and safer than long-term therapy with intravenous cyclophosphamide." | 5.11 | Sequential therapies for proliferative lupus nephritis. ( Contreras, G; Leclercq, B; Lenz, O; O'Nan, P; Pardo, V; Roth, D; Tozman, E, 2004) |
| "Thirty-eight patients with diffuse glomerulonephritis of systemic lupus erythematosus were randomly assigned to add cyclophosphamide, azathioprine, or nothing to low-dose corticosteroid treatment and have been followed for a mean of 21/3 years thereafter." | 5.04 | Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months. ( Decker, JL; Klippel, JH; Plotz, PH; Steinberg, AD, 1975) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 3.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "Pemphigus vulgaris is the commonest clinical type." | 1.33 | Twelve-year clinico-therapeutic experience in pemphigus: a retrospective study of 54 cases. ( Garg, G; Mahajan, VK; Sharma, NL; Sharma, RC, 2005) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Contreras, G | 1 |
| Pardo, V | 1 |
| Leclercq, B | 1 |
| Lenz, O | 1 |
| Tozman, E | 1 |
| O'Nan, P | 1 |
| Roth, D | 1 |
| Mahajan, VK | 1 |
| Sharma, NL | 1 |
| Sharma, RC | 1 |
| Garg, G | 1 |
| Hodgkinson, DJ | 1 |
| Williams, TJ | 2 |
| Decker, JL | 1 |
| Klippel, JH | 1 |
| Plotz, PH | 1 |
| Steinberg, AD | 1 |
| Thumb, N | 1 |
| Kim, HH | 1 |
| Snaith, ML | 1 |
| Holt, JM | 1 |
| Oliver, DO | 1 |
| Dunnill, MS | 1 |
| Halley, W | 1 |
| Stephenson, AC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Multicenter Study to Assess the Efficacy on Diseases Activity of Enteric-coated Mycophenolate Sodium Versus Continuation of Azathioprine in Patients With Systemic Lupus Erythematosus on Azathioprine Maintenance Therapy.[NCT00504244] | Phase 3 | 12 participants (Actual) | Interventional | 2007-07-31 | Terminated (stopped due to Insufficient recruitment) | ||
| Five-Year Single-Blind, Phase III Effectiveness Randomised Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis: Oral Cyclophosphamide Versus High Dose Intravenous Cyclophosphamide Versus Intermediate Dose Intrav[NCT00336414] | Phase 3 | 0 participants (Actual) | Interventional | 2006-06-30 | Withdrawn (stopped due to the study is withdrawn due to low and unexpected enrollment rate) | ||
| CYCLONES - CYClophosphamide LOw Dose and No Extra Steroid[NCT03492255] | 49 participants (Actual) | Interventional | 2018-04-12 | Terminated (stopped due to Significative difference between percentage of renal response (primary outcome) between the two study arms.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for azathioprine and Amenorrhea
| Article | Year |
|---|---|
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Sequential therapies for proliferative lupus nephritis.
Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi | 2004 |
Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months.
Topics: Adolescent; Adult; Amenorrhea; Azathioprine; Child; Clinical Trials as Topic; Complement C3; Cycloph | 1975 |
5 other studies available for azathioprine and Amenorrhea
| Article | Year |
|---|---|
Twelve-year clinico-therapeutic experience in pemphigus: a retrospective study of 54 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amenorrhea; Azathioprine; Betamethasone; Blood Pressure; | 2005 |
Endometrial carcinoma associated with azathioprine and cortisone therapy. A case report.
Topics: Adenocarcinoma; Adult; Amenorrhea; Azathioprine; Female; Genital Neoplasms, Female; Humans; Immunity | 1977 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Endometrioid carcinoma of the uterus and ovaries associated with immunosuppressive therapy and anticoagulation: report of a case.
Topics: Adenocarcinoma; Adult; Amenorrhea; Anticoagulants; Azathioprine; Endometriosis; Female; Humans; Immu | 1972 |
Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil.
Topics: Adult; Alopecia; Amenorrhea; Azathioprine; Biopsy; Bone Marrow; Chlorambucil; Cyclophosphamide; Cyst | 1973 |