Page last updated: 2024-10-23

azathioprine and Aging

azathioprine has been researched along with Aging in 16 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Azathioprine was also introduced earlier (20."1.30[Diffuse jejuno-ileitis of Crohn's disease: a separate form of the disease?]. ( Colombel, JF; Cortot, A; Gower-Rousseau, C; Grandbastien, B; Paris, JC; Quandalle, P; Touze, I, 1999)
"Thymoma was more common in the older population; these patients did no worse than the population as a whole."1.28The relationship of age to outcome in myasthenia gravis. ( Ansher, M; Donaldson, DH; Horan, S; Ringel, SP; Rutherford, RB, 1990)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199010 (62.50)18.7374
1990's3 (18.75)18.2507
2000's0 (0.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Willington, AJ1
Gearry, RB1
Broekman, MMTJ1
Wanten, GJ1
de Jong, DJ1
Loit, E1
Tricco, AC1
Tsouros, S1
Sears, M1
Ansari, MT1
Booth, RA1
Walford, RL1
Peters, TG1
Charlton, RK1
Jones, KW1
Goodrich, JP1
Sill, TM1
King, TB1
Touze, I1
Gower-Rousseau, C1
Grandbastien, B1
Paris, JC1
Quandalle, P1
Cortot, A1
Colombel, JF1
Menahan, LA1
Kemp, RG1
Bach, JF1
Dardenne, M1
Pleau, JM1
Bach, MA1
Gershwin, ME1
Steinberg, AD1
Woody, JN1
Ahmed, A1
Donaldson, DH1
Ansher, M1
Horan, S1
Rutherford, RB1
Ringel, SP1
Leunissen, KM1
Bosman, FT1
Kootstra, G1
van Hooff, JP1
Hayes, JM1
Novick, AC1
Steinmuller, DR1
Streem, SB1
Hodge, EE1
Bretan, PN1
Cunningham, R1
Graneto, D1
Trivedi, P1
Cheeseman, P1
Portmann, B1
Hegarty, J1
Mowat, AP1
Bailey, GL1
Mocelin, AJ1
Griffiths, HJ1
Zschaeck, D1
Ghantous, WN1
Hampers, CL1
Merrill, JP1
Wilson, RE1
Hurley, RM1
Drummond, KN1
Bender, AD1
Kormendy, CG1
Powell, R1

Reviews

2 reviews available for azathioprine and Aging

ArticleYear
Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.
    Clinical biochemistry, 2011, Volume: 44, Issue:10-11

    Topics: Aging; Azathioprine; Enzyme Stability; Health Care Surveys; Hematocrit; Humans; Mercaptopurine; Meth

2011
Pharmacological control of aging.
    Experimental gerontology, 1970, Volume: 5, Issue:2

    Topics: Aging; Allergy and Immunology; Animals; Antioxidants; Azathioprine; Cell Biology; Central Nervous Sy

1970

Other Studies

14 other studies available for azathioprine and Aging

ArticleYear
Editorial: thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype-the perils of ageing.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:1

    Topics: Aging; Azathioprine; Genotype; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercap

2018
Editorial: thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype-the perils of ageing. Authors' reply.
    Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:1

    Topics: Aging; Azathioprine; Genotype; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercap

2018
The role of autoimmune phenomena in the ageing process.
    Symposia of the Society for Experimental Biology, 1967, Volume: 21

    Topics: Aging; Amyloidosis; Animals; Appendix; Autoantibodies; Azathioprine; Cricetinae; Fishes; Hemolysin P

1967
Kidney transplantation in the older patient.
    The Journal of the Florida Medical Association, 1994, Volume: 81, Issue:8

    Topics: Aged; Aging; Azathioprine; Cause of Death; Cyclosporine; Female; Florida; Follow-Up Studies; Graft R

1994
[Diffuse jejuno-ileitis of Crohn's disease: a separate form of the disease?].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Aging; Azathioprine; Crohn Disease; Enteritis; Female; Humans; Ileal Diseases; Je

1999
The effect of several lymphocytotoxic agents on murine leukemogenesis.
    Life sciences, 1978, Oct-23, Volume: 23, Issue:16

    Topics: Aging; Animals; Azathioprine; Body Weight; Cortisone; Dacarbazine; Leukemia, Experimental; Lymphocyt

1978
Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human.
    Annals of the New York Academy of Sciences, 1975, Feb-28, Volume: 249

    Topics: Aging; Animals; Antilymphocyte Serum; Arthritis, Rheumatoid; Autoantibodies; Azathioprine; Cell-Free

1975
Studies of thymic factors. I. Evaluation of the mouse rosette assay for thymic hormone.
    Journal of immunology (Baltimore, Md. : 1950), 1975, Volume: 115, Issue:5

    Topics: Aging; Animals; Antilymphocyte Serum; Azathioprine; DNA, Single-Stranded; Female; Immune Adherence R

1975
The relationship of age to outcome in myasthenia gravis.
    Neurology, 1990, Volume: 40, Issue:5

    Topics: Adrenal Cortex Hormones; Aged; Aging; Antibodies; Autoimmune Diseases; Azathioprine; Combined Modali

1990
The effect of cyclosporine A on renal graft function is dependent on donor age.
    Transplantation proceedings, 1988, Volume: 20, Issue:3 Suppl 3

    Topics: Aging; Azathioprine; Cyclosporins; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Predniso

1988
Improved results using pediatric cadaver donor kidneys with cyclosporine immunosuppression.
    Transplantation proceedings, 1988, Volume: 20, Issue:3 Suppl 3

    Topics: Aging; Antilymphocyte Serum; Azathioprine; Child, Preschool; Cyclosporins; Drug Administration Sched

1988
Variation in serum type III procollagen peptide with age in healthy subjects and its comparative value in the assessment of disease activity in children and adults with chronic active hepatitis.
    European journal of clinical investigation, 1985, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Azathioprine; Child; Child, Preschool; Hepatitis, Chronic; Humans; I

1985
Hemodialysis and renal transplantation in patients of the 50-80 age group.
    Journal of the American Geriatrics Society, 1972, Volume: 20, Issue:9

    Topics: Aged; Aging; Azathioprine; Blood Glucose; Cysts; Diabetes Mellitus; Female; Glomerulonephritis; Gluc

1972
Glomerular enlargement in primary renal disease: a quantitative study.
    Archives of pathology, 1974, Volume: 97, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aging; Autopsy; Azathioprine; Biopsy; Child; Child, Preschool; Cyclo

1974