azathioprine has been researched along with Adverse Drug Event in 71 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current myasthenia gravis guidelines recommend the use of azathioprine as first-line steroid sparing agent." | 9.41 | Methotrexate in generalized myasthenia gravis: a systematic review. ( Adiao, KJB; Prado, MB, 2023) |
| "Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs)." | 8.91 | Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis. ( Fu, WL; Huang, Q; Li, M; Liu, YP; Xu, HQ; Yang, X; Yu, S, 2015) |
| "Current myasthenia gravis guidelines recommend the use of azathioprine as first-line steroid sparing agent." | 5.41 | Methotrexate in generalized myasthenia gravis: a systematic review. ( Adiao, KJB; Prado, MB, 2023) |
| "Our work supports the strong evidence that individuals with TPMT variant homozygosity are at high risk of severe neutropenia, whereas TPMT heterozygotes are not at increased risk of ADRs at standard doses of azathioprine." | 5.15 | A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study. ( Alder, JE; Andrews, J; Bruce, I; Elles, R; Elliott, RA; Fargher, E; Griffiths, CE; Heise, M; Houston, JB; Newman, WG; Ollier, WE; Payne, D; Payne, K; Pushpakom, S; Qasim, F; Ramsden, SC; Ray, DW; Roberts, SA; Shaffer, J; Sidgwick, GP; Tricker, K, 2011) |
| "Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs)." | 4.91 | Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis. ( Fu, WL; Huang, Q; Li, M; Liu, YP; Xu, HQ; Yang, X; Yu, S, 2015) |
| " In this review, we summarise current knowledge on the adverse effects of azathioprine, mycophenolate mofetil, rituximab, tocilizumab, eculizumab, satralizumab, and inebilizumab in NMOSD." | 2.82 | Adverse Events in NMOSD Therapy. ( Berthele, A; Giglhuber, K, 2022) |
| "Azathioprine is an accessible drug for patients in many countries, including underdeveloped countries, and therefore it is used by many dermatologists in moderate and severe AD." | 2.82 | The use of azathioprine in atopic dermatitis: A review. ( Bracho-Borro, M; Franco-Ruiz, PA; Magaña, M, 2022) |
| "Azathioprine (AZA) is a thiopurine prodrug commonly used in patients with kidney transplantation." | 2.75 | Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients. ( Li, Q; Wu, XC; Xin, HW; Xiong, H; Xiong, L; Yu, AR, 2010) |
| "The efficacy and safety of thiopurines in autoimmune hepatitis can be improved by investigational efforts that establish monitoring strategies that allow individualisation of dosage and prediction of outcome, increase bioavailability of the active metabolites and demonstrate superiority to alternative agents." | 2.66 | Review article: opportunities to improve and expand thiopurine therapy for autoimmune hepatitis. ( Czaja, AJ, 2020) |
| "First-line treatment for autoimmune hepatitis (AIH) typically includes corticosteroids in combination with azathioprine." | 2.61 | Systematic review with meta-analysis: mycophenolate mofetil as a second-line therapy for autoimmune hepatitis. ( Levy, C; Santiago, P; Schwartz, I; Tamariz, L, 2019) |
| "To evaluate the relationship between thiopurine S-methyltransferase (TPMT) polymorphisms and thiopurine-induced adverse drug reactions (ADRs) in inflammatory bowel disease (IBD)." | 2.46 | Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease. ( Dong, XW; Ran, ZH; Tong, JL; Zheng, Q; Zhu, MM, 2010) |
| "In clinical trials, up to 15% of patients discontinued 6-mercaptopurine or its pro-drug azathioprine prematurely due to adverse events." | 2.42 | Safety of thiopurines in the treatment of inflammatory bowel disease. ( de Jong, DJ; Derijks, LJ; Hooymans, PM; Mulder, CJ; Naber, AH, 2003) |
| "Approximately 25% of patients with inflammatory bowel disease (IBD) discontinue azathioprine (AZA) or mercaptopurine (MP) therapy within 3 months of treatment initiation because of adverse drug reactions." | 1.72 | Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients. ( Bus, P; Creemers, RH; de Boer, NKH; Deben, DS; Pierik, MJ; Simsek, M; van Bodegraven, AA; van Moorsel, SAW; Winkens, B; Wong, DR, 2022) |
| "We assessed the incidence and predictive factors of thiopurine-induced adverse events (AE) resulting in therapy cessation in pediatric inflammatory bowel disease (IBD), related to thiopurine metabolites and biochemical abnormalities, and determined overall drug survival." | 1.72 | Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study. ( Benninga, MA; Buiter, HJC; de Boer, NKH; de Meij, TGJ; Jagt, JZ; Pothof, CD; van Limbergen, JE; van Wijk, MP, 2022) |
| " The most frequent adverse events were typical for usually administered immunosuppressive treatment." | 1.56 | Treatment and its side effects in ANCA-associated vasculitides - Study based on POLVAS registry data. ( Biedroń, G; Brzosko, I; Brzosko, M; Czuszyńska, Z; Dębska-Ślizień, A; Głuszko, P; Hawrot-Kawecka, A; Jakuszko, K; Jeleniewicz, R; Klinger, M; Kucharz, EJ; Kur-Zalewska, J; Madej, M; Majdan, M; Masiak, A; Musiał, J; Rowaiye, OO; Storoniak, H; Szczeklik, W; Sznajd, J; Tłustochowicz, W; Wawrzycka-Adamczyk, K; Wisłowska, M; Wójcik, K; Włudarczyk, A; Zdrojewski, Z, 2020) |
| "Almost a quarter of inflammatory bowel disease patients treated with thiopurines developed adverse effects." | 1.56 | Toxicity profile of thiopurines in inflammatory bowel disease: a retrospective cohort analysis. ( Ben Mustapha, N; Boubaker, J; Fekih, M; Hafi, M; Labidi, A; Serghini, M, 2020) |
| "Lupus nephritis is one of the major manifestations of SLE." | 1.56 | The Prevalence and Causes of Non-adherence to Immunosuppressive Medications in Patients with Lupus Nephritis Flares. ( Abdelaziz, TS; Ali, AY; Behiry, ME, 2020) |
| " Moreover, acute liver failure after multiple dosing of azathioprine was investigated in a patient case study by use of own clinical data." | 1.46 | Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients. ( Blank, LM; Castell, JV; Conde, I; Cordes, H; Kuepfer, L; Thiel, C, 2017) |
| "415C>T mutation was the likely cause of the adverse reaction." | 1.43 | Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report. ( Ailing, Z; Jing, Y; Jingli, L; Xiaojian, Z; Yun, X, 2016) |
| "Comparison with other studies is limited by varying definitions of adverse effects." | 1.42 | The adverse effect profile of oral azathioprine in pediatric atopic dermatitis, and recommendations for monitoring. ( Bragoli, W; Fuggle, NR; Glover, M; Kinsler, VA; Mahto, A; Martinez, AE, 2015) |
| "Long-term incidence of adverse events was estimated in patients from a prospectively maintained Spanish nationwide database using Kaplan-Meier analysis." | 1.39 | Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients. ( Aldeguer, X; Barreiro-de Acosta, M; Barrio, J; Bastida, G; Cabré, E; Cabriada, JL; Ceña, G; Chaparro, M; Esteve, M; García-Planella, E; Garcia-Sanchez, V; Garcia-Sepulcre, M; Gisbert, JP; Gomollón, F; Gutiérrez, A; Hinojosa, J; Márquez, L; Maté, J; Mendoza, JL; Merino, O; Montoro, MA; Muñoz, F; Ordás, I; Peñalva, M; Saro, C; Vera, I, 2013) |
| "Etiologies of acute pancreatitis (AP) in children are more variable than in adults, including drugs, traumas, infections and multisystem disorders as well as biliary anomalies." | 1.38 | Acute and recurrent pancreatitis in children: exploring etiological factors. ( De Cunto, A; Martelossi, S; Minen, F; Ventura, A, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " Dosing was guided by measuring thiopurine methyltransferase (for UK patients) or thioguanine nucleotides and methyl-6MP (Australian patients)." | 1.36 | Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease. ( Ansari, A; Duley, JA; Florin, TH; O'Donohue, J; Patel, N; Sanderson, J, 2010) |
| " We describe the case of a young patient with ulcerative colitis, homozygous for TPMT*3A alleles, who suffered fatal azathioprine-induced myelotoxicity after standard dosing with azathioprine." | 1.35 | Fatal myelotoxicity after azathioprine treatment. ( Bortlík, M; Chalupná, P; Krska, Z; Lukás, M; Novotný, A; Slanar, O, 2008) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "Patients with other causes of acute pancreatitis or chronic pancreatitis were excluded from the analysis." | 1.32 | Are drugs a risk factor of post-ERCP pancreatitis? ( Bauret, P; Berthier, E; Blanc, F; Blayac, JP; Fabbro-Peray, P; Hanslik, B; Hillaire-Buys, D; Larrey, D; Melki, M; Pageaux, GP; Perney, P; Roques, V, 2003) |
| " While many effects on the immune system's components can be found as a result of a drug treatment or chemical exposure, true immunotoxicity occurs when such treatment results in adverse effects or defects in the immune response." | 1.32 | Adequate immunotoxicity testing in drug development. ( Gore, ER; Herzyk, DJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (16.90) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (11.27) | 29.6817 |
| 2010's | 30 (42.25) | 24.3611 |
| 2020's | 21 (29.58) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Casajús, A | 1 |
| Zubiaur, P | 1 |
| Méndez, M | 1 |
| Campodónico, D | 1 |
| Gómez, A | 1 |
| Navares-Gómez, M | 1 |
| Villapalos-García, G | 1 |
| Soria-Chacartegui, P | 1 |
| Novalbos, J | 1 |
| Román, M | 1 |
| Mejía-Abril, G | 1 |
| Ochoa, D | 1 |
| Abad-Santos, F | 1 |
| Viviano, KR | 1 |
| Giglhuber, K | 1 |
| Berthele, A | 1 |
| Rodda, SE | 1 |
| Fildes, KJ | 1 |
| Shelton, E | 1 |
| Goldberg, R | 1 |
| Moore, GT | 1 |
| Bracho-Borro, M | 1 |
| Franco-Ruiz, PA | 1 |
| Magaña, M | 1 |
| van Moorsel, SAW | 2 |
| Deben, DS | 1 |
| Creemers, RH | 1 |
| Winkens, B | 1 |
| Bus, P | 1 |
| Pierik, MJ | 1 |
| Simsek, M | 1 |
| de Boer, NKH | 4 |
| van Bodegraven, AA | 2 |
| Wong, DR | 1 |
| Prado, MB | 1 |
| Adiao, KJB | 1 |
| Bei, W | 1 |
| Qian, J | 1 |
| Zilu, Q | 1 |
| Kai, C | 1 |
| Ruili, J | 1 |
| Feng, H | 1 |
| Liuqing, C | 1 |
| Biedroń, G | 1 |
| Włudarczyk, A | 1 |
| Wawrzycka-Adamczyk, K | 1 |
| Wójcik, K | 1 |
| Sznajd, J | 1 |
| Zdrojewski, Z | 1 |
| Masiak, A | 1 |
| Czuszyńska, Z | 1 |
| Majdan, M | 1 |
| Jeleniewicz, R | 1 |
| Klinger, M | 1 |
| Jakuszko, K | 1 |
| Rowaiye, OO | 1 |
| Brzosko, M | 1 |
| Brzosko, I | 1 |
| Dębska-Ślizień, A | 1 |
| Storoniak, H | 1 |
| Tłustochowicz, W | 1 |
| Kur-Zalewska, J | 1 |
| Wisłowska, M | 1 |
| Madej, M | 1 |
| Hawrot-Kawecka, A | 1 |
| Głuszko, P | 1 |
| Kucharz, EJ | 1 |
| Musiał, J | 1 |
| Szczeklik, W | 1 |
| Calafat, M | 1 |
| Mañosa, M | 1 |
| Mesonero, F | 1 |
| Guardiola, J | 1 |
| Mínguez, M | 1 |
| Nos, P | 1 |
| Vera, I | 2 |
| Taxonera, C | 1 |
| Iglesias, E | 1 |
| Ricart, E | 1 |
| Gisbert, JP | 2 |
| Calvet, X | 1 |
| García-López, S | 1 |
| Monfort, D | 1 |
| Pérez Calle, JL | 1 |
| Riestra, S | 1 |
| Gomollón, F | 2 |
| Garcia-Planella, E | 2 |
| Bermejo, F | 1 |
| Hernández, V | 1 |
| Martín-Arranz, MD | 1 |
| Gutiérrez, A | 2 |
| Torres, P | 1 |
| Cañete, F | 1 |
| Domènech, E | 1 |
| Kreijne, JE | 1 |
| de Vries, AC | 1 |
| de Veer, RC | 1 |
| Bouma, G | 3 |
| Dijkstra, G | 1 |
| Voskuil, MD | 1 |
| West, R | 1 |
| de Jong, DJ | 2 |
| de Boer, NK | 1 |
| van der Woude, CJ | 1 |
| Czaja, AJ | 1 |
| Labidi, A | 1 |
| Hafi, M | 1 |
| Ben Mustapha, N | 1 |
| Serghini, M | 1 |
| Fekih, M | 1 |
| Boubaker, J | 1 |
| Garner, S | 1 |
| Khalidi, N | 1 |
| Chadalavada, P | 1 |
| Simons-Linares, CR | 1 |
| Chahal, P | 1 |
| Zeze, K | 1 |
| Hirano, A | 1 |
| Torisu, T | 1 |
| Esaki, M | 1 |
| Moriyama, T | 1 |
| Umeno, J | 1 |
| Kawasaki, K | 1 |
| Fujioka, S | 1 |
| Fuyuno, Y | 1 |
| Matsuno, Y | 1 |
| Kitazono, T | 1 |
| Szczeklik, K | 1 |
| Darczuk, D | 1 |
| Krok-Ziółkowska, J | 1 |
| Ligara, J | 1 |
| Kuszaj, M | 1 |
| Cibor, D | 1 |
| Pytko-Polończyk, J | 1 |
| Owczarek, D | 1 |
| van den Bosch, BJ | 1 |
| Coenen, MJ | 1 |
| Jagt, JZ | 1 |
| Pothof, CD | 1 |
| Buiter, HJC | 1 |
| van Limbergen, JE | 1 |
| van Wijk, MP | 1 |
| Benninga, MA | 1 |
| de Meij, TGJ | 1 |
| Giraud, EL | 1 |
| Thomas, PWA | 1 |
| van Lint, JA | 1 |
| van Puijenbroek, EP | 1 |
| Römkens, TEH | 1 |
| West, RL | 1 |
| Russel, MGVM | 1 |
| Jansen, JM | 1 |
| Jessurun, NT | 1 |
| Hoentjen, F | 1 |
| Meijer, B | 1 |
| Seinen, ML | 1 |
| van Egmond, R | 1 |
| Mulder, CJJ | 2 |
| Orandi, AB | 1 |
| Vogel, TP | 1 |
| Keppel, MP | 1 |
| Utterson, EC | 1 |
| Cooper, MA | 1 |
| Coucoutsi, C | 1 |
| Emmanouil, G | 1 |
| Goulielmos, G | 1 |
| Sfakianaki, O | 1 |
| Koutroubakis, IE | 1 |
| Kouroumalis, EA | 1 |
| Roblin, X | 1 |
| Flourié, B | 1 |
| Paul, S | 1 |
| Eriksson, C | 1 |
| Rundquist, S | 1 |
| Cao, Y | 1 |
| Montgomery, S | 1 |
| Halfvarson, J | 1 |
| van den Brand, FF | 1 |
| van Nieuwkerk, CMJ | 1 |
| Verwer, BJ | 1 |
| de Boer, YS | 1 |
| Bloemena, E | 1 |
| Bakker, CM | 1 |
| Vrolijk, JM | 1 |
| Drenth, JPH | 1 |
| Tan, ACITL | 1 |
| Ter Borg, F | 1 |
| Ter Borg, MJ | 1 |
| van den Hazel, SJ | 1 |
| Inderson, A | 1 |
| Tushuizen, ME | 1 |
| Santiago, P | 1 |
| Schwartz, I | 1 |
| Tamariz, L | 1 |
| Levy, C | 1 |
| Ali, AY | 1 |
| Abdelaziz, TS | 1 |
| Behiry, ME | 1 |
| Chang, JY | 1 |
| Cheon, JH | 1 |
| Chaparro, M | 1 |
| Ordás, I | 1 |
| Cabré, E | 1 |
| Garcia-Sanchez, V | 1 |
| Bastida, G | 1 |
| Peñalva, M | 1 |
| Merino, O | 1 |
| Esteve, M | 1 |
| Márquez, L | 1 |
| Garcia-Sepulcre, M | 1 |
| Hinojosa, J | 1 |
| Muñoz, F | 1 |
| Mendoza, JL | 1 |
| Cabriada, JL | 1 |
| Montoro, MA | 1 |
| Barreiro-de Acosta, M | 1 |
| Ceña, G | 1 |
| Saro, C | 1 |
| Aldeguer, X | 1 |
| Barrio, J | 1 |
| Maté, J | 1 |
| Teich, N | 1 |
| Patel, VN | 1 |
| Kaelber, DC | 1 |
| de Wit, KL | 1 |
| White, BE | 1 |
| Goldsmith, D | 1 |
| Spence, AD | 1 |
| Lee, R | 1 |
| Keegan, D | 1 |
| Doherty, GA | 1 |
| Mulcahy, H | 1 |
| Murphy, S | 1 |
| Fuggle, NR | 1 |
| Bragoli, W | 1 |
| Mahto, A | 1 |
| Glover, M | 1 |
| Martinez, AE | 1 |
| Kinsler, VA | 1 |
| Roberts, RL | 1 |
| Barclay, ML | 1 |
| Liu, YP | 1 |
| Xu, HQ | 1 |
| Li, M | 1 |
| Yang, X | 1 |
| Yu, S | 1 |
| Fu, WL | 1 |
| Huang, Q | 1 |
| Thiel, C | 1 |
| Cordes, H | 1 |
| Conde, I | 1 |
| Castell, JV | 1 |
| Blank, LM | 1 |
| Kuepfer, L | 1 |
| Ailing, Z | 1 |
| Jing, Y | 1 |
| Jingli, L | 1 |
| Yun, X | 1 |
| Xiaojian, Z | 1 |
| Watelet, B | 1 |
| Samson, M | 1 |
| de Boysson, H | 1 |
| Bienvenu, B | 1 |
| Slanar, O | 1 |
| Chalupná, P | 1 |
| Novotný, A | 1 |
| Bortlík, M | 1 |
| Krska, Z | 1 |
| Lukás, M | 1 |
| Xiong, H | 1 |
| Xin, HW | 1 |
| Wu, XC | 1 |
| Li, Q | 1 |
| Xiong, L | 1 |
| Yu, AR | 1 |
| Ansari, A | 1 |
| Patel, N | 1 |
| Sanderson, J | 1 |
| O'Donohue, J | 1 |
| Duley, JA | 1 |
| Florin, TH | 1 |
| Lee, CY | 1 |
| Jin, C | 1 |
| Mata, AM | 1 |
| Tanaka, T | 1 |
| Einarson, A | 1 |
| Koren, G | 1 |
| Dong, XW | 1 |
| Zheng, Q | 1 |
| Zhu, MM | 1 |
| Tong, JL | 1 |
| Ran, ZH | 1 |
| Newman, WG | 1 |
| Payne, K | 1 |
| Tricker, K | 1 |
| Roberts, SA | 1 |
| Fargher, E | 1 |
| Pushpakom, S | 1 |
| Alder, JE | 1 |
| Sidgwick, GP | 1 |
| Payne, D | 1 |
| Elliott, RA | 1 |
| Heise, M | 1 |
| Elles, R | 1 |
| Ramsden, SC | 1 |
| Andrews, J | 1 |
| Houston, JB | 1 |
| Qasim, F | 1 |
| Shaffer, J | 1 |
| Griffiths, CE | 1 |
| Ray, DW | 1 |
| Bruce, I | 1 |
| Ollier, WE | 1 |
| Minen, F | 1 |
| De Cunto, A | 1 |
| Martelossi, S | 1 |
| Ventura, A | 1 |
| Siva, C | 1 |
| Yokoyama, WM | 1 |
| McLeod, HL | 1 |
| Perney, P | 1 |
| Berthier, E | 1 |
| Pageaux, GP | 1 |
| Hillaire-Buys, D | 1 |
| Roques, V | 1 |
| Fabbro-Peray, P | 1 |
| Melki, M | 1 |
| Hanslik, B | 1 |
| Bauret, P | 1 |
| Larrey, D | 1 |
| Blayac, JP | 1 |
| Blanc, F | 1 |
| Derijks, LJ | 1 |
| Naber, AH | 1 |
| Hooymans, PM | 1 |
| Mulder, CJ | 1 |
| Herzyk, DJ | 1 |
| Gore, ER | 1 |
| Kozu, T | 1 |
| Erskine, IA | 1 |
| Mackay, JM | 1 |
| Fox, DP | 1 |
| Wańkowicz, Z | 1 |
| Kałczak, M | 1 |
| Panasiuk, E | 1 |
| Ciszkiewicz, Z | 1 |
| Elston, DM | 1 |
| McClure, PD | 1 |
| Rambaldi, M | 1 |
| Russo, R | 1 |
| Iaquinto, G | 1 |
| Agozzino, L | 1 |
| De Cristofano, R | 1 |
| Thaler, H | 1 |
| Schill, WB | 1 |
| Przybilla, B | 1 |
| Dobrilla, G | 2 |
| Felder, M | 2 |
| Chilovi, F | 2 |
| Eisner, JW | 1 |
| Koch, HR | 1 |
| Hockwin, O | 1 |
| Gynn, TN | 1 |
| Messmore, HL | 1 |
| Friedman, IA | 1 |
| Tuchmann-Duplessis, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Baricitinib Versus Azathioprine in Combination With Topical Corticosteroids For Patients With Moderate-to-Severe Atopic Dermatitis[NCT05969730] | 40 participants (Anticipated) | Interventional | 2023-08-15 | Recruiting | |||
| Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO[NCT03841734] | Phase 3 | 8 participants (Anticipated) | Interventional | 2019-03-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 reviews available for azathioprine and Adverse Drug Event
| Article | Year |
|---|---|
Glucocorticoids, Cyclosporine, Azathioprine, Chlorambucil, and Mycophenolate in Dogs and Cats: Clinical Uses, Pharmacology, and Side Effects.
Topics: Animals; Azathioprine; Cat Diseases; Cats; Chlorambucil; Cyclosporine; Dog Diseases; Dogs; Drug-Rela | 2022 |
Adverse Events in NMOSD Therapy.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosuppressive Agents; Myc | 2022 |
The use of azathioprine in atopic dermatitis: A review.
Topics: Azathioprine; Dermatitis, Atopic; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosup | 2022 |
Methotrexate in generalized myasthenia gravis: a systematic review.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosuppressive Agents; Met | 2023 |
Comparing four immunosuppressive agents for chronic spontaneous urticaria-A network meta-analysis.
Topics: Anti-Allergic Agents; Azathioprine; Chronic Disease; Chronic Urticaria; Cyclosporine; Drug-Related S | 2023 |
Review article: opportunities to improve and expand thiopurine therapy for autoimmune hepatitis.
Topics: Allopurinol; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Guanine Nucleotides; Hep | 2020 |
Updates in the treatment of granulomatosis with polyangiitis and microscopic polyangiitis: At a crossroad.
Topics: Adrenal Cortex Hormones; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathioprine; C | 2020 |
Pharmacogenetics of inflammatory bowel disease.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Genetic Markers; Humans; Immunosuppre | 2021 |
Systematic review with meta-analysis: mycophenolate mofetil as a second-line therapy for autoimmune hepatitis.
Topics: Antibiotics, Antineoplastic; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Female; | 2019 |
Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Azathioprine; Colitis, Ulcerative; Crohn Disease; Dru | 2019 |
Thiopurine toxicity.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans | 2013 |
Update on thiopurine pharmacogenetics in inflammatory bowel disease.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Hypersensitivity; Drug-Related Side Effects a | 2015 |
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis.
Topics: Autoimmune Diseases; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosu | 2015 |
Treatment of giant-cell arteritis, a literature review.
Topics: Antirheumatic Agents; Azathioprine; Drug Therapy, Combination; Drug-Related Side Effects and Adverse | 2017 |
Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease.
Topics: Adult; Azathioprine; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Im | 2010 |
Pharmacogenetics in rheumatology: the prospects and limitations of an emerging field.
Topics: Analgesics, Opioid; Antirheumatic Agents; Azathioprine; Drug Design; Drug Interactions; Drug-Related | 2002 |
Safety of thiopurines in the treatment of inflammatory bowel disease.
Topics: Azathioprine; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosuppre | 2003 |
[Drug-induced pancreatitis].
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azathioprine; | 2007 |
Idiopathic thrombocytopenic purpura in children: diagnosis and management.
Topics: Age Factors; Autoantibodies; Autoimmune Diseases; Azathioprine; Blood Cell Count; Blood Coagulation | 1975 |
[Pancreatitis caused by drugs].
Topics: Adult; Azathioprine; Chlorothiazide; Contraceptives, Oral; Drug-Related Side Effects and Adverse Rea | 1977 |
[Side effects of drugs on male fertility].
Topics: Anabolic Agents; Animals; Antifungal Agents; Antineoplastic Agents; Azathioprine; Colchicine; Dacarb | 1985 |
Drugs used in allergic states and their mode of action.
Topics: Anti-Inflammatory Agents; Asthma; Azathioprine; Catecholamines; Cromolyn Sodium; Drug-Related Side E | 1973 |
Drug-induced thrombocytopenia.
Topics: Aged; Agglutination Tests; Alkaloids; Alkylating Agents; Anti-Bacterial Agents; Anticonvulsants; Ant | 1972 |
2 trials available for azathioprine and Adverse Drug Event
| Article | Year |
|---|---|
Association between inosine triphosphate pyrophosphohydrolase deficiency and azathioprine-related adverse drug reactions in the Chinese kidney transplant recipients.
Topics: Aged; Asian People; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Female; Gastroint | 2010 |
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Drug-Related Side Effects and Adverse | 2011 |
46 other studies available for azathioprine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Genotype-Guided Prescription of Azathioprine Reduces the Incidence of Adverse Drug Reactions in TPMT Intermediate Metabolizers to a Similar Incidence as Normal Metabolizers.
Topics: Allopurinol; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Humans | 2022 |
Impact of a pharmacist-led thiopurine monitoring service in outpatients with inflammatory bowel disease.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans; Inflammatory Bowel Diseases; | 2023 |
Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients.
Topics: Algorithms; Azathioprine; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adve | 2022 |
Treatment and its side effects in ANCA-associated vasculitides - Study based on POLVAS registry data.
Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathioprine; Cyclophosphamide; D | 2020 |
Switching to a Second Thiopurine in Adult and Elderly Patients With Inflammatory Bowel Disease: A Nationwide Study From the ENEIDA Registry.
Topics: Adult; Age Factors; Aged; Azathioprine; Drug Monitoring; Drug Substitution; Drug Tolerance; Drug-Rel | 2020 |
Limited added value of laboratory monitoring in thiopurine maintenance monotherapy in inflammatory bowel disease patients.
Topics: Adult; Allopurinol; Azathioprine; Clinical Laboratory Techniques; Drug Monitoring; Drug-Related Side | 2020 |
Toxicity profile of thiopurines in inflammatory bowel disease: a retrospective cohort analysis.
Topics: Adolescent; Adult; Azathioprine; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; Fe | 2020 |
Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Doxycycline; Drug-Related Side Effects and | 2020 |
Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn's Disease: A Retrospective Study.
Topics: Adult; Antimetabolites; Azathioprine; Biological Products; Crohn Disease; Drug Monitoring; Drug Syne | 2021 |
Oral non-specific lesions in patient with Crohn's disease - a case report.
Topics: Adalimumab; Adult; Azathioprine; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; Fem | 2020 |
Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Topics: Adolescent; Antimetabolites; Azathioprine; Biomarkers, Pharmacological; Child; Cohort Studies; Colit | 2022 |
Adverse Drug Reactions from Real-World Data in Inflammatory Bowel Disease Patients in the IBDREAM Registry.
Topics: Adverse Drug Reaction Reporting Systems; Azathioprine; Drug-Related Side Effects and Adverse Reactio | 2021 |
Optimizing Thiopurine Therapy in Inflammatory Bowel Disease Among 2 Real-life Intercept Cohorts: Effect of Allopurinol Comedication?
Topics: Adult; Allopurinol; Azathioprine; Drug Monitoring; Drug Therapy, Combination; Drug-Related Side Effe | 2017 |
Azathioprine-Associated Complete NK Cell Deficiency.
Topics: Azathioprine; CD56 Antigen; Child, Preschool; Cytotoxicity, Immunologic; Drug-Related Side Effects a | 2017 |
Prevalence of thiopurine S-methyltransferase gene polymorphisms in patients with inflammatory bowel disease from the island of Crete, Greece.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Case-Control Studies; Drug-Related Side Ef | 2017 |
Low Doses of Azathioprine are Effective in Combination With Infliximab in Inflammatory Bowel Disease but May not be During Induction Therapy.
Topics: Azathioprine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Drug-Rela | 2018 |
Impact of thiopurines on the natural history and surgical outcome of ulcerative colitis: a cohort study.
Topics: Adult; Azathioprine; Colectomy; Colitis, Ulcerative; Disease Progression; Drug-Related Side Effects | 2019 |
Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands.
Topics: Adolescent; Adult; Aged; Azathioprine; Biomarkers; Child; Drug-Related Side Effects and Adverse Reac | 2018 |
The Prevalence and Causes of Non-adherence to Immunosuppressive Medications in Patients with Lupus Nephritis Flares.
Topics: Adult; Azathioprine; Disease Progression; Drug Costs; Drug-Related Side Effects and Adverse Reaction | 2020 |
Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug-Related Side Effects and Adverse React | 2013 |
[News on Azathioprine in IBD].
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; F | 2013 |
Using aggregated, de-identified electronic health record data for multivariate pharmacosurveillance: a case study of azathioprine.
Topics: Adverse Drug Reaction Reporting Systems; Azathioprine; Data Mining; Drug-Related Side Effects and Ad | 2014 |
Awareness of adverse effects of azathioprine in patients with inflammatory bowel disease--more to be done?
Topics: Awareness; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosupp | 2014 |
The adverse effect profile of oral azathioprine in pediatric atopic dermatitis, and recommendations for monitoring.
Topics: Administration, Oral; Azathioprine; Child; Dermatitis, Atopic; Drug Monitoring; Drug-Related Side Ef | 2015 |
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.
Topics: Adult; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Si | 2017 |
Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report.
Topics: Adult; Asian People; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans | 2016 |
Fatal myelotoxicity after azathioprine treatment.
Topics: Adult; Azathioprine; Bone Marrow; Colitis, Ulcerative; Drug-Related Side Effects and Adverse Reactio | 2008 |
Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Azathioprine; Drug Therapy, Combination; Dr | 2010 |
A pilot study of paternal drug exposure: the Motherisk experience.
Topics: Azathioprine; Breast Feeding; Cohort Studies; Counseling; Databases, Factual; Drug-Related Side Effe | 2010 |
Acute and recurrent pancreatitis in children: exploring etiological factors.
Topics: Adolescent; Azathioprine; Biliary Tract; Biliary Tract Diseases; Carrier Proteins; Child; Child, Pre | 2012 |
Are drugs a risk factor of post-ERCP pancreatitis?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Cholangiopancreatography, Endoscopic Retro | 2003 |
Adequate immunotoxicity testing in drug development.
Topics: Animals; Antibody Formation; Azathioprine; Cyclosporine; Drug Evaluation, Preclinical; Drug-Related | 2004 |
Monitoring patients on long-term drug therapy for genotoxic effects.
Topics: Atenolol; Azathioprine; Cells, Cultured; Chlorpropamide; Chronic Disease; Drug-Related Side Effects | 1984 |
[Acute drug-induced renal failure with severe clinical course].
Topics: Acute Kidney Injury; Adolescent; Anti-Infective Agents; Anticoagulants; Azathioprine; Diuretics; Dru | 1982 |
Photo quiz. Drug-induced pemphigus foliaceus.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Stero | 2000 |
[Hepatitis and cirrhosis].
Topics: Adrenal Cortex Hormones; Azathioprine; Biopsy; Chronic Disease; Drug-Related Side Effects and Advers | 1975 |
[Proven relationship between drugs and pancreatitis].
Topics: Asparaginase; Azathioprine; Diuretics; Drug-Related Side Effects and Adverse Reactions; Estrogens; H | 1986 |
[Acute drug-induced pancreatitis].
Topics: Acute Disease; Asparaginase; Azathioprine; Chlorothiazide; Drug-Related Side Effects and Adverse Rea | 1985 |
[Iatrogenic cataracts].
Topics: Aged; Anesthetics, Local; Anthelmintics; Azathioprine; Cataract; Chloroquine; Chlorpromazine; Dimeth | 1974 |
Teratogenic drug screening. Present procedures and requirements.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Animals, Laboratory; Azathioprine; Ca | 1972 |