azathioprine has been researched along with Acute Myelogenous Leukemia in 32 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Azathioprine is widely used in patients with autoimmune diseases and after organ allografting." | 4.86 | Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia. ( Kwong, YL, 2010) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Four cases of acute myelogenous leukemia and six cases of chronic myelogenous leukemia after treatment with azathioprine and prednisone for renal allotransplantation have been described in the literature." | 3.66 | [Acute leukemia after kidney allotransplantation (author's transl)]. ( Binswanger, U; Briner, J; Fehr, J; Frei, D; Largiadèr, F; Sauter, C, 1980) |
| "Azathioprine, which is an immunosuppressive agent commonly used for chronic inflammatory bowel disease, may be associated with an increased risk of certain cancers such as hematologic malignancies." | 1.91 | Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn's disease. ( Asma, M; Emna, BM; Nadia, B; Nouha, T; Yosra, S; Yosra, Z, 2023) |
| "that describes potential risk of acute myeloid leukemia or myeloproliferative disorder among thiopurine therapy." | 1.62 | The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits? ( Ha, C, 2021) |
| "Azathioprine sodium use was observed more frequently in cases (odds ratio [OR], 7." | 1.46 | Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia. ( Al-Kali, A; Castro, J; Dueck, A; Ertz-Archambault, N; Finn, L; Foran, J; Gauthier, S; Kelemen, K; Kosiorek, H; Marino, R; Mesa, RA; Palmer, J; Sproat, LZ; Taylor, GE; Tibes, R, 2017) |
| "Secondary acute myeloid leukemia is a very rare complication in patients with solid organ transplantation." | 1.42 | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. ( Guerra, C; Melo, J; Peña, C; Sepúlveda, C, 2015) |
| "We describe a case of acute nonlymphocytic leukemia with inversion of chromosome 16 in a patient with systemic lupus erythematosus treated with immunosuppressive agents including azathioprine and cyclophosphamide." | 1.28 | Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents. ( Kavanaugh, AF; Lipsky, PE; Schneider, NR; Vasquez, S; Wacholtz, MC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 4 (12.50) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Nouha, T | 1 |
| Asma, M | 1 |
| Nadia, B | 1 |
| Emna, BM | 1 |
| Yosra, Z | 1 |
| Yosra, S | 1 |
| Ha, C | 1 |
| Tibes, R | 2 |
| Ertz-Archambault, N | 2 |
| Kosiorek, H | 2 |
| Meijer, B | 1 |
| de Boer, NKH | 1 |
| Lopez, A | 1 |
| Mounier, M | 1 |
| Bouvier, AM | 1 |
| Carrat, F | 1 |
| Maynadié, M | 1 |
| Beaugerie, L | 1 |
| Peyrin-Biroulet, L | 1 |
| Deepak, P | 1 |
| Stobaugh, DJ | 1 |
| Schmutz, JL | 1 |
| Peña, C | 1 |
| Sepúlveda, C | 1 |
| Melo, J | 1 |
| Guerra, C | 1 |
| Taylor, GE | 1 |
| Kelemen, K | 1 |
| Dueck, A | 1 |
| Castro, J | 1 |
| Marino, R | 1 |
| Gauthier, S | 1 |
| Finn, L | 1 |
| Sproat, LZ | 1 |
| Palmer, J | 1 |
| Mesa, RA | 1 |
| Al-Kali, A | 1 |
| Foran, J | 1 |
| Burki, TK | 1 |
| Kwong, YL | 2 |
| Kallel, L | 1 |
| Naijaa, N | 1 |
| Fekih, M | 1 |
| Frikha, I | 1 |
| Boubaker, J | 1 |
| Bellaaj, H | 1 |
| Romdhane, NB | 1 |
| Filali, A | 1 |
| Chin, LK | 1 |
| Cheah, CY | 1 |
| Michael, PM | 1 |
| MacKinnon, RN | 1 |
| Campbell, LJ | 1 |
| Mullier, F | 1 |
| Rahier, JF | 1 |
| Maignen, F | 1 |
| Cornet, Y | 1 |
| Graux, C | 1 |
| Chatelain, C | 1 |
| Chatelain, B | 1 |
| Dogne, JM | 1 |
| You, E | 1 |
| Yang, JJ | 1 |
| Cho, SY | 1 |
| Lee, HJ | 1 |
| Lee, WI | 1 |
| Kim, HJ | 1 |
| Yoon, HJ | 1 |
| Park, TS | 1 |
| Yenson, PR | 1 |
| Forrest, D | 1 |
| Schmiegelow, K | 1 |
| Dalal, BI | 1 |
| Frei, D | 1 |
| Binswanger, U | 1 |
| Fehr, J | 1 |
| Briner, J | 1 |
| Sauter, C | 1 |
| Largiadèr, F | 1 |
| Leithner, C | 1 |
| Kübböck, J | 1 |
| Winterleitner, H | 1 |
| Pavelka, M | 1 |
| Krisch, K | 1 |
| Mok, CC | 1 |
| Lau, CS | 1 |
| Gilmore, IT | 1 |
| Holden, G | 1 |
| Rodan, KS | 1 |
| Sieber, SM | 1 |
| Vasquez, S | 1 |
| Kavanaugh, AF | 1 |
| Schneider, NR | 1 |
| Wacholtz, MC | 1 |
| Lipsky, PE | 1 |
| Guseva, SA | 1 |
| Butler, J | 1 |
| Korb, S | 1 |
| Light, J | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
| Cooper, MR | 1 |
| Hansen, KS | 1 |
| Maynard, CD | 1 |
| Elrod, IW | 1 |
| Spurr, CL | 1 |
| Rosenberg, EB | 1 |
| Herberman, RB | 1 |
| Levine, PH | 1 |
| Halterman, RH | 1 |
| McCoy, JL | 1 |
| Wunderlich, JR | 1 |
| Silvergleid, AJ | 1 |
| Schrier, SL | 1 |
| Storti, E | 1 |
| Traldi, A | 1 |
| Quaglino, D | 1 |
| Pawelski, S | 2 |
| Maj, S | 2 |
3 reviews available for azathioprine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Azathioprine: association with therapy-related myelodysplastic syndrome and acute myeloid leukemia.
Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Female; Graft Rejection; Humans; Immunosuppressive A | 2010 |
A case of therapy-related myeloid neoplasm in a patient with Crohn's disease treated with azathioprine.
Topics: Aged; Antineoplastic Agents; Azathioprine; Bone Marrow; Chromosome Aberrations; Crohn Disease; Human | 2012 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; | 1977 |
1 trial available for azathioprine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Clinical studies on the effects of imuran and vincristine in the treatment of leukaemia.
Topics: Adult; Azathioprine; Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Leukemia; Le | 1968 |
28 other studies available for azathioprine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Acute myeloid leukemia after 10 years of azathioprine treatment for Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia | 2023 |
The Age-Old Conundrum With Thiopurines: Are the Accumulating Risks Greater Than Benefits?
Topics: Azathioprine; Humans; Incidence; Inflammatory Bowel Diseases; Leukemia, Myeloid, Acute; Myelodysplas | 2021 |
All Thiopurines Are Equal But Some Thiopurines Are More Equal Than Others-Reply.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
All Thiopurines Are Equal but Some Thiopurines Are More Equal Than Others.
Topics: Autoimmune Diseases; Azathioprine; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Myelodysplastic | 2018 |
Increased risk of acute myeloid leukemias and myelodysplastic syndromes in patients who received thiopurine treatment for inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Cohort Studies; Female; France; Humans; Immunosuppressive Agents; I | 2014 |
Risk of Myeloid Neoplasms in Inflammatory Bowel Disease Patients Is Linked to Exposure to Thiopurines and Not With Tumor Necrosis Factor-alpha Inhibitors.
Topics: Azathioprine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukemia, Myelo | 2015 |
[Neutrophilic eccrine hidradenitis and azathioprine hypersensitivity syndrome].
Topics: Azathioprine; Crohn Disease; Diagnosis, Differential; Drug Hypersensitivity; Hidradenitis; Humans; I | 2014 |
[Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case].
Topics: Azathioprine; Bone Marrow; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Immunosuppress | 2015 |
Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Case-Control Stud | 2017 |
Azathioprine associated with myeloid neoplasm risk.
Topics: Autoimmune Diseases; Azathioprine; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Myelo | 2017 |
Acute myeloid leukemia after one month of azathioprine therapy in a Crohn's disease patient.
Topics: Adult; Azathioprine; Chromosomes, Human, Pair 21; Crohn Disease; Humans; Immunosuppressive Agents; I | 2010 |
11q23 rearrangement and duplication of MLLT1-MLL gene fusion in therapy-related acute myeloid leukemia.
Topics: Azathioprine; Chromosome Banding; Chromosomes, Human, Pair 11; Cyclosporine; Female; Gene Duplicatio | 2012 |
Therapy-related acute myeloid leukemia in Crohn's disease.
Topics: Azathioprine; Crohn Disease; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male | 2013 |
Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency.
Topics: Adult; Azathioprine; Bone Marrow; Crohn Disease; Female; Genotype; Humans; Leukemia, Myeloid, Acute; | 2008 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1983. A young man with pancytopenia after a renal transplant.
Topics: Adult; Azathioprine; Diagnosis, Differential; Humans; Kidney Transplantation; Leukemia, Myeloid, Acu | 1983 |
[Acute leukemia after kidney allotransplantation (author's transl)].
Topics: Adult; Azathioprine; Humans; Kidney Transplantation; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; M | 1980 |
[Acute myelogenous leukaemia after renal transplantation (author's transl)].
Topics: Adult; Azathioprine; Humans; Kidney Failure, Chronic; Kidney Transplantation; Leukemia, Myeloid, Acu | 1981 |
Secondary acute myeloid leukaemia with 7q- complicating azathioprine treatment for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Leukemia, Myeloid, Acute; Neoplasms, Seco | 1995 |
Acute leukaemia during azathioprine therapy.
Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Leukemia, Myeloid, Acute | 1977 |
Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents.
Topics: Adult; Azathioprine; Chromosomes, Human, Pair 16; Cyclophosphamide; Female; Humans; Immunosuppressiv | 1992 |
[The diagnostic significance of the test for spontaneous blood neutrophil damage in acute myeloid forms of leukemia].
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Azat | 1990 |
Acute myelogenous leukemia in a renal allograft recipient receiving cyclosporine therapy.
Topics: Azathioprine; Cyclosporins; Female; Humans; Kidney Transplantation; Leukemia, Myeloid, Acute; Middle | 1990 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |
Platelet survival and sequestration patterns in thrombocytopenic disorders.
Topics: Adult; Aged; Azathioprine; Blood Platelets; Cell Survival; Chloramphenicol; Chromium Isotopes; Dexam | 1972 |
Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins.
Topics: Adolescent; Adult; Aged; Antigens; Azathioprine; Child; Child, Preschool; Chromium Isotopes; Cycloph | 1972 |
Acute myelogenous leukemia in two patients treated with azathioprine for nonmalignant diseases.
Topics: Adult; Azathioprine; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Cells; Cytarabine; | 1974 |
Comparison of the results of combined treatment of acute myeloblastic leukemias with corticosteroids and either imuran or 6-mercaptopurine.
Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Female; Humans; Infections; Leukemia, Myeloid, | 1971 |
Comparison of the results of combined treatment of acute myeloblastic leukemias with corticosteroids and either imuran or 6-mercaptopurine.
Topics: Acute Disease; Adolescent; Adult; Aged; Azathioprine; Female; Humans; Infections; Leukemia, Myeloid, | 1971 |