azathioprine has been researched along with Acute Lymphoid Leukemia in 19 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this report, we describe the safe and effective use of trametinib combined with dasatinib in a patient with acute lymphoblastic leukemia (ALL)." | 1.62 | Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report. ( Hu, BF; Shen, SH; Wang, GL; Wang, J, 2021) |
| "Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality." | 1.38 | Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus. ( Besbas, N; Bilginer, Y; Bulus, D; Cetin, M; Gokce, M; Gumruk, F, 2012) |
| "The renal biopsy showed type I membranoproliferative glomerulonephritis." | 1.36 | Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation. ( Chang, YS; Chung, S; Kim, B; Kim, JY; Lee, MY; Park, CW, 2010) |
| "A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning." | 1.31 | A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. ( Nakaseko, C; Nishimura, M; Saito, Y; Uehara, T; Yokota, A, 2002) |
| "The use of azathioprine in ulcerative colitis is unclear." | 1.28 | The role of azathioprine in the management of ulcerative colitis. ( Axon, AT; Burke, DA; Foster, PN; Johnston, D; Lobo, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Marinaki, AM | 1 |
| Arenas-Hernandez, M | 1 |
| Franca, R | 1 |
| Stocco, G | 1 |
| Favretto, D | 1 |
| Giurici, N | 1 |
| Del Rizzo, I | 1 |
| Locatelli, F | 1 |
| Vinti, L | 1 |
| Biondi, A | 1 |
| Colombini, A | 1 |
| Fagioli, F | 1 |
| Barisone, E | 1 |
| Pelin, M | 1 |
| Martellossi, S | 1 |
| Ventura, A | 1 |
| Decorti, G | 2 |
| Rabusin, M | 1 |
| Pavlovic, S | 1 |
| Kotur, N | 1 |
| Stankovic, B | 1 |
| Gasic, V | 1 |
| Lucafo, M | 1 |
| Zukic, B | 1 |
| Wang, J | 1 |
| Shen, SH | 1 |
| Hu, BF | 1 |
| Wang, GL | 1 |
| Hawwa, AF | 1 |
| Millership, JS | 1 |
| Collier, PS | 1 |
| Vandenbroeck, K | 1 |
| McCarthy, A | 1 |
| Dempsey, S | 1 |
| Cairns, C | 1 |
| Collins, J | 1 |
| Rodgers, C | 1 |
| McElnay, JC | 1 |
| Cesarini, M | 1 |
| Vernia, P | 1 |
| Angelucci, E | 1 |
| Kim, JY | 1 |
| Lee, MY | 1 |
| Kim, B | 1 |
| Park, CW | 1 |
| Chang, YS | 1 |
| Chung, S | 1 |
| Gokce, M | 1 |
| Bulus, D | 1 |
| Bilginer, Y | 1 |
| Gumruk, F | 1 |
| Besbas, N | 1 |
| Cetin, M | 1 |
| Vikingsson, S | 1 |
| Almer, S | 2 |
| Peterson, C | 2 |
| Carlsson, B | 1 |
| Josefsson, M | 1 |
| Uehara, T | 1 |
| Nakaseko, C | 1 |
| Yokota, A | 1 |
| Saito, Y | 1 |
| Nishimura, M | 1 |
| Marshall, E | 1 |
| Coulthard, SA | 2 |
| Matheson, EC | 1 |
| Hall, AG | 2 |
| Hogarth, LA | 1 |
| Johnson, F | 1 |
| Hunt, S | 1 |
| Sergeev, PV | 1 |
| Dukhanin, AS | 1 |
| Stankevich, LI | 1 |
| Erina, TA | 1 |
| Bulaeva, NN | 1 |
| Semeĭkin, AV | 1 |
| Aarbakke, J | 1 |
| Janka-Schaub, G | 1 |
| Elion, GB | 1 |
| Bergan, S | 1 |
| Norge, O | 1 |
| Rabello, C | 1 |
| Robson, J | 1 |
| Howell, C | 1 |
| Minto, L | 1 |
| Middleton, PG | 1 |
| Gandhi, MK | 1 |
| Jackson, G | 1 |
| McLelland, J | 1 |
| O'Brien, H | 1 |
| Smith, S | 1 |
| Reid, MM | 1 |
| Pearson, AD | 1 |
| Pettersson, B | 1 |
| Albertioni, F | 1 |
| Söderhäll, S | 1 |
| Lobo, AJ | 1 |
| Foster, PN | 1 |
| Burke, DA | 1 |
| Johnston, D | 1 |
| Axon, AT | 1 |
3 reviews available for azathioprine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Reducing risk in thiopurine therapy.
Topics: Azathioprine; Drug Hypersensitivity; Erythrocytes; Female; Genotype; Humans; Male; Mercaptopurine; M | 2020 |
Clinical Application of Thiopurine Pharmacogenomics in Pediatrics.
Topics: Azathioprine; Genetic Markers; Humans; Inflammatory Bowel Diseases; Pediatrics; Pharmacogenetics; Pr | 2020 |
The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.
Topics: Alanine; Antimetabolites, Antineoplastic; Azathioprine; DNA; DNA Methylation; Drug Resistance, Neopl | 2004 |
2 trials available for azathioprine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Azathioprine; Child; Child, Preschool; Coho | 2020 |
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Topics: Adult; Age Factors; Antimetabolites, Antineoplastic; Azathioprine; Child; Drug Therapy, Combination; | 2002 |
14 other studies available for azathioprine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Child; Consolidation Che | 2021 |
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Azathioprine; Child; Child, Preschool; Female; Gene Fre | 2008 |
Acute lymphoid leukemia in a Crohn's disease patient during treatment with adalimumab after a prolonged treatment with azathioprine and steroids.
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aza | 2010 |
Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation.
Topics: Adult; Azathioprine; Glomerulonephritis, Membranoproliferative; Graft vs Host Disease; Hematopoietic | 2010 |
Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus.
Topics: Antimetabolites; Azathioprine; Child; Fatal Outcome; Female; Humans; Lupus Erythematosus, Systemic; | 2012 |
Monitoring of thiopurine metabolites - a high-performance liquid chromatography method for clinical use.
Topics: Adult; Analytic Sample Preparation Methods; Antimetabolites, Antineoplastic; Azathioprine; Biotransf | 2013 |
A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Bone Marrow Trans | 2002 |
Preventing toxicity with a gene test.
Topics: Advisory Committees; Azathioprine; Child; Drug Labeling; Drug Utilization; Genetic Testing; Humans; | 2003 |
Recurrent lymphoma in a cardiac allograft recipient.
Topics: Azathioprine; Cyclosporine; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Lung | 1994 |
[Comparative study of the interaction of purine antagonists with adenosine receptors of bone marrow lymphocytes and lymphoblasts].
Topics: Azathioprine; Bone Marrow; Bone Marrow Cells; Humans; Lymphocytes; Mercaptopurine; Precursor Cell Ly | 1993 |
Thiopurine biology and pharmacology.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cloning, Molecular; Genotype; Humans; Immuno | 1997 |
[Better therapeutic potential for azathioprine and mercaptopurine].
Topics: Antimetabolites, Antineoplastic; Azathioprine; Child; Genotype; Humans; Mercaptopurine; Methyltransf | 2000 |
A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations.
Topics: Adolescent; Adult; Azathioprine; Blood Donors; Child; Child, Preschool; DNA Mutational Analysis; Fem | 2000 |
The role of azathioprine in the management of ulcerative colitis.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Female; Humans; Leukopenia; Lymphoma, Non-Hodgkin; Male; M | 1990 |