Compounds > azathioprine
Page last updated: 2024-10-23

azathioprine and Acute Liver Injury, Drug-Induced

azathioprine has been researched along with Acute Liver Injury, Drug-Induced in 171 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2."9.126-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. ( Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C, 2007)
"We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient."7.81Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. ( Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M, 2015)
"We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver."7.77[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011)
" Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case."7.70Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999)
"We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency."7.68Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity. ( Devogelaer, JP; Geubel, A; Meys, E; Nagant de Deuxchaisnes, C; Rahier, J, 1992)
"Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third patient showed very high fever and severe chills."7.68Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; Kruijsen, MW; van de Putte, LB, 1990)
"A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease."7.66Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982)
"Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from severe psoriasis."7.65Treatment of psoriasis with azathioprine. ( Du Vivier, A; Munro, DD; Verbov, J, 1974)
"Azathioprine is an immunosuppressive medication used in the management of many autoimmune conditions."6.50Azathioprine-induced hepatitis and cholestasis occurring 1 year after treatment. ( Alam, S; Black, M; Chertoff, J; Elgendy, IY, 2014)
"Three weeks after starting AZA for the treatment of uveitis, the patient was admitted to our clinic with cholestasis and constitutional symptoms."5.51Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019)
"Azathioprine (AZA) is an immunosuppressant frequently used for treatment of various autoimmune conditions, including MG."5.43A Review of Azathioprine-Associated Hepatotoxicity and Myelosuppression in Myasthenia Gravis. ( Hulley, D; Jack, KL; Koopman, WJ; Nicolle, MW, 2016)
"There are substantial global differences in the preference for mercaptopurine (MP) or its prodrug azathioprine (AZA) as first-choice thiopurine to treat inflammatory bowel diseases."5.24More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing. ( Broekman, MMTJ; Coenen, MJH; de Jong, DJ; Derijks, LJJ; Guchelaar, HJ; Hooymans, PM; Klungel, OH; Scheffer, H; van Marrewijk, CJ; Verbeek, ALM; Wanten, GJA; Wong, DR, 2017)
"A prospective randomized trial in patients with Crohn disease studied whether 6-thioguanine nucleotide (6-TGN) concentration-adapted azathioprine (AZA) therapy is clinically superior to a standard dose of 2."5.126-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. ( Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C, 2007)
" The variety of acute hepatitis include hepatitis A, hepatitis B, cytomegalovirus hepatitis, herpes simplex hepatitis and azathioprine hepatitis."4.75Liver disease in renal transplant recipients. ( Anuras, S; Sopko, J, 1978)
" Acute cholestasis is one of the most common forms of hepatotoxicity induced by azathioprine."4.12Severe azathioprine-induced liver injury 22 months after initiation of treatment. ( Battezzati, PM; Cataletti, G; Pastorelli, L; Santagata, F, 2022)
"We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient."3.81Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. ( Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M, 2015)
"Thiopurines (azathioprine, 6-mercaptopurine) are a mainstay of treatment in Crohn disease (CD)."3.80Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease. ( Amre, D; Deslandres, C; Kopylov, U; Seidman, EG; Theoret, Y, 2014)
"We report the case of a 53-year-old man with Crohn's disease who developed azathioprine-induced nodular regenerative hyperplasia of the liver."3.77[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease]. ( Corbatón, P; de la Fuente-Fernández, E; Gisbert, JP; López-Martín, C; Sánchez, MC, 2011)
" Some histopathological features consistent with azathioprine hepatotoxicity like cholestasis, perisinusoidal fibrosis, veno-subocclusive lesions and nodular regenerative hyperplasia were also observed in this case."3.70Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor? ( Aguado, JM; Colina, F; Delgado, J; Fuertes, A; Gomez, MA; Ibarrola, C; Morales, JM; Muñoz de Bustillo, E; Rodriguez, E, 1999)
"Azathioprine and rheumatoid arthritis are known to be associated with an increased risk of the development of non-Hodgkin's lymphoma; however, the manifestation of fulminant hepatic failure is extremely uncommon in patients with non-Hodgkin's lymphoma."3.69Azathioprine-induced lymphoma manifesting as fulminant hepatic failure. ( Aguilar, HI; Burgart, LJ; Geller, A; Rakela, J, 1997)
"Within one year three of 25 patients with rheumatoid arthritis treated with azathioprine 100 mg daily developed the following adverse reactions less than two weeks after starting treatment: patient one showed fever with chills, rash, and severe liver function abnormalities suggestive of cholestasis; the second patient had fever, nausea, diarrhoea, and moderately raised liver enzymes; the third patient showed very high fever and severe chills."3.68Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; Kruijsen, MW; van de Putte, LB, 1990)
"We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency."3.68Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity. ( Devogelaer, JP; Geubel, A; Meys, E; Nagant de Deuxchaisnes, C; Rahier, J, 1992)
"Three cases of azathioprine-induced complex of liver diseases are described, and their light microscopy and ultrastructural findings are detailed."3.67Role of endothelial cell injury in the spectrum of azathioprine-induced liver disease after renal transplant: light microscopy and ultrastructural observations. ( Ackrill, P; Ali, HH; Haboubi, NY; Whitwell, HL, 1988)
"A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease."3.66Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982)
"Azathioprine treatment benefited 19 (66%) out of 29 patients suffering from severe psoriasis."3.65Treatment of psoriasis with azathioprine. ( Du Vivier, A; Munro, DD; Verbov, J, 1974)
"Hepatotoxicity, gastrointestinal complaints and general malaise are common limiting adverse reactions of azathioprine and mercaptopurine in IBD patients, often related to high steady-state 6-methylmercaptopurine ribonucleotide (6-MMPR) metabolite concentrations."2.84Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease. ( Coenen, MJ; de Jong, DJ; Derijks, LJ; Engels, LG; Franke, B; Guchelaar, HJ; Hooymans, PM; Klungel, OH; Scheffer, H; van Marrewijk, CJ; Verbeek, AL; Vermeulen, SH; Wong, DR, 2017)
" However, adverse events leading to discontinuation may occur in 10-20% of patients."2.716-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment. ( de Jong, DJ; Derijks, LJ; Engels, LG; Gilissen, LP; Hooymans, PM; Jansen, JB; Mulder, CJ, 2003)
" Fortunately, the absolute incidence of serious toxicity remains low, and an improved understanding of how best to minimize risk and the recognition of groups of patients at higher risk of toxicity from thiopurines means that they remain a relatively safe therapy in the majority of patients."2.52Toxicity and response to thiopurines in patients with inflammatory bowel disease. ( Goldberg, R; Irving, PM, 2015)
" However, the dosing and the duration of immunosuppressive therapy have not been systematically studied in the setting of treating ipilimumab-induced irAEs."2.52Ipilimumab-induced toxicities and the gastroenterologist. ( Bye, W; Cheng, R; Cooper, A; Kench, J; McNeil, C; Shackel, N; Watson, G, 2015)
"Azathioprine is an immunosuppressive medication used in the management of many autoimmune conditions."2.50Azathioprine-induced hepatitis and cholestasis occurring 1 year after treatment. ( Alam, S; Black, M; Chertoff, J; Elgendy, IY, 2014)
"The addition of low dose allopurinol to dose-reduced thiopurine analogue seems safe but careful monitoring for adverse effects and profiling of thiopurine metabolites is essential."2.44Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol. ( Gearry, RB; Leong, RW; Sparrow, MP, 2008)
"Azathioprine was not associated with thrombocytopenia, anaemia or neutropenia in any dogs."1.72Prevalence of hepatotoxicity and myelosuppression with alternate day use of azathioprine and glucocorticoids for treatment of dermatological conditions in dogs. ( Eberhardy, AC; Heinrich, NA; McFadden, RA; Reiter, LV, 2022)
"Approximately 25% of patients with inflammatory bowel disease (IBD) discontinue azathioprine (AZA) or mercaptopurine (MP) therapy within 3 months of treatment initiation because of adverse drug reactions."1.72Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients. ( Bus, P; Creemers, RH; de Boer, NKH; Deben, DS; Pierik, MJ; Simsek, M; van Bodegraven, AA; van Moorsel, SAW; Winkens, B; Wong, DR, 2022)
"Three weeks after starting AZA for the treatment of uveitis, the patient was admitted to our clinic with cholestasis and constitutional symptoms."1.51Severe cholestasis due to azathioprine in Behcet's disease. ( Gisi, K; Ispiroglu, M; Kantarceken, B; Sayar, H, 2019)
"A 15-year-old girl was diagnosed with influenza and prescribed 40 mg laninamivir."1.51Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate. ( Arinaga-Hino, T; Hirai, S; Ide, T; Kawaguchi, T; Nagamatsu, H; Shimizu, M; Takata, A; Tanikawa, K; Tateishi, H; Tokushige, T; Torimura, T, 2019)
" Indications for switch, dosing and subsequent clinical outcomes (including thiopurine persistence) were recorded."1.48Low-dose thiopurine with allopurinol co-therapy overcomes thiopurine intolerance and allows thiopurine continuation in inflammatory bowel disease. ( Beswick, L; Friedman, AB; Haridy, J; Moltzen, A; Raghunath, A; Sparrow, M; van Langenberg, D; Vasudevan, A, 2018)
" Moreover, acute liver failure after multiple dosing of azathioprine was investigated in a patient case study by use of own clinical data."1.46Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients. ( Blank, LM; Castell, JV; Conde, I; Cordes, H; Kuepfer, L; Thiel, C, 2017)
"Azathioprine (AZA) is an immunosuppressant frequently used for treatment of various autoimmune conditions, including MG."1.43A Review of Azathioprine-Associated Hepatotoxicity and Myelosuppression in Myasthenia Gravis. ( Hulley, D; Jack, KL; Koopman, WJ; Nicolle, MW, 2016)
"Overall, 113/164 (69%) patients with Crohn's disease and 83/136 (61%) patients with ulcerative/unclassified colitis had a clinical response by the end of follow-up (median 19 months), while 85 (52%) patients with Crohn's disease and 74 (54%) patients with ulcerative/unclassified colitis were in clinical remission."1.43Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study. ( Abdulrehman, A; Ansari, A; Bull, C; Duley, J; Kerr, P; Pavlidis, P; Stamoulos, P, 2016)
" This study aims to detect TPMT polymorphisms and TPMT enzyme activity in Chinese SLE patients and to describe the association between TPMT genotypes and adverse effects of AZA."1.40Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. ( Chen, D; Lian, F; Liang, L; Qiu, Q; Wang, Y; Xu, H; Yang, X; Ye, Y; Yuan, S; Zhan, Z, 2014)
"A retrospective cohort of 176 Crohn's Disease (CD) patients treated with thiopurines (131 with 6MP and 45 with azathioprine) was genotyped for common polymorphisms in GSTM1, GSTT1 and TPMT."1.39Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. ( Chowers, Y; Efrati, E; Elkin, H; Karban, A; Koifman, E; Krivoy, N; Mazor, Y, 2013)
" The primary outcome was the occurrence of 6-thioguanine induced hepatotoxicity, scaled according to the Common Terminology Criteria for Adverse Events."1.38Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment. ( de Boer, NK; Mulder, CJ; Seinen, ML; van Asseldonk, DP; van Bodegraven, AA, 2012)
" 13 adverse events occurred, including 6 specific to co-therapy (3 rash, 2 abnormal liver function tests, 1 dosing error)."1.38Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol. ( Anderson, SH; Blaker, P; Irving, PM; Marinaki, AM; Sanderson, JD; Smith, MA, 2012)
"Patients with ornidazole-induced toxic hepatitis with autoimmune hepatitis were included to constitute the study group of this report."1.37Ornidazole-induced autoimmune hepatitis. ( Akarca, US; Ersöz, G; Günşar, F; Karasu, Z; Tekın, F; Vardar, R; Yilmaz, F, 2011)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
"Immunosuppressants are among the pharmacological agents with the greatest potential to cause adverse reactions, although induction of hepatotoxicity is paradoxical from the pathogenic point of view, since the response of the innate and acquired immune system is a key element in the chain of events leading to chemical liver damage."1.36[Hepatotoxicity induced by new immunosuppressants]. ( Andrade, RJ; Cotta, J; Lucena, MA; Robles, M; Toscano, E, 2010)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Following repeated liver biopsy, autoimmune hepatitis was assumed and prednisolone and azathioprine were initiated."1.35[Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report]. ( Hartmann, U; Reuss-Borst, M; Schmitt, S, 2008)
"Two patients developed acute pancreatitis."1.34Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. ( Bohane, TD; Day, AS; Lee, D; Naidoo, D; Ooi, CY, 2007)
"61); among the 34 responders, the median dosage of the drug required to obtain remission was lower for mutated than for wild type patients (1."1.33TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease. ( Barabino, A; Bartoli, F; Decorti, G; Fezzi, M; Fontana, M; Giraldi, T; Lionetti, P; Malusà, N; Martelossi, S; Stocco, G; Ventura, A, 2005)
"Azathioprine (AZA) is an important drug used in the therapy of autoimmune system disorders."1.32A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. ( Ahmad, M; Al-Shabanah, OA; Gado, A; Raza, M, 2003)
"Twenty-two per cent of patients discontinued azathioprine prematurely probably as a result of related adverse events."1.32Side effects of azathioprine in patients with Crohn's disease. ( de Jong, DJ; Goullet, M; Naber, TH, 2004)
"Azathioprine was discontinued."1.27Favourable outcome of hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine, treated by portacaval shunt. Report of a case and review of the literature. ( Creutzfeldt, W; Eisenhauer, T; Hartmann, H; Helmchen, U; Rumpf, KW; Scheler, F, 1984)
"Azathioprine was discontinued."1.27Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature. ( Adler, M; Cremer, M; De Pauw, L; Delhaye, M; Deprez, C; Gelin, M; Hardy, N; Toussaint, C; Vereerstraeten, P, 1987)
"Azathioprine was later withdrawn in 29 (66%), in 6 because of side effects and in 20 because of clinical and biochemical improvement."1.27Chronic active hepatitis. Experience from a Norwegian reference hospital during a decade. ( Elgjo, K; Opedal, I; Ritland, S, 1985)
"Esophageal varices were demonstrated."1.27Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation. ( Assmann, KM; Deckers, PF; Driessen, WM; Gerlag, PG; Lobatto, S; Schröder, E; Van Haelst, UJ; Van Hooff, JP, 1985)
" Neither histopathological changes were observed, nor could any deaths be directly attributed to toxic effects of the drug on hepatocytes."1.26Azathioprine hepatotoxicity, direct complication or secondary effect in rat liver transplantation. ( Hess, F; Jerusalem, C; Polak, M, 1976)

Research

Studies (171)

TimeframeStudies, this research(%)All Research%
pre-199069 (40.35)18.7374
1990's15 (8.77)18.2507
2000's26 (15.20)29.6817
2010's55 (32.16)24.3611
2020's6 (3.51)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Dawson, S1
Stahl, S2
Paul, N1
Barber, J1
Kenna, JG2
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Abdul-Hamid, M1
Abdel-Reheim, ES1
Hegazy, W1
Allam, A1
Othman, SI1
Alwaele, MA1
Abdel-Kawi, SH1
Eberhardy, AC1
Heinrich, NA1
McFadden, RA1
Reiter, LV1
van Moorsel, SAW1
Deben, DS1
Creemers, RH1
Winkens, B1
Bus, P1
Pierik, MJ1
Simsek, M1
de Boer, NKH1
van Bodegraven, AA2
Wong, DR3
Cataletti, G1
Santagata, F1
Pastorelli, L1
Battezzati, PM1
Phillips, J1
Preskey, R1
Penfold, C1
Gordon, F1
Tyrrell-Price, J1
Nakashima, K1
Demura, Y1
Oi, M1
Tabata, M1
Tada, T1
Shiozaki, K1
Akai, M1
Ishizuka, T1
Siramolpiwat, S1
Sakonlaya, D1
Iwamoto, K1
Ishitsuka, Y1
Tanaka, R1
Sekine, I1
Fujimoto, M1
Broekman, MMTJ1
Coenen, MJH1
van Marrewijk, CJ2
Wanten, GJA1
Verbeek, ALM1
Klungel, OH2
Hooymans, PM3
Guchelaar, HJ2
Scheffer, H2
Derijks, LJJ1
de Jong, DJ4
Koller, T1
Galambosova, M1
Filakovska, S1
Kubincova, M1
Hlavaty, T1
Toth, J1
Krajcovicova, A1
Payer, J1
Vasudevan, A1
Beswick, L1
Friedman, AB1
Moltzen, A1
Haridy, J1
Raghunath, A1
Sparrow, M1
van Langenberg, D1
Wang, CH1
Chi, MH1
Lin, JY1
Chung, WH1
Chen, CB1
Gisi, K1
Ispiroglu, M1
Kantarceken, B1
Sayar, H1
Kawaguchi, T1
Arinaga-Hino, T1
Shimizu, M1
Tanikawa, K1
Tokushige, T1
Hirai, S1
Nagamatsu, H1
Tateishi, H1
Takata, A1
Ide, T1
Torimura, T1
Ruiz-Clavijo, D1
Arín, A1
Vila, JJ1
Albéniz, E1
Picazo, R1
Casi, M1
Matsuo, K1
Sasaki, E1
Higuchi, S1
Takai, S1
Tsuneyama, K1
Fukami, T1
Nakajima, M1
Yokoi, T1
Chen, D2
Lian, F1
Yuan, S1
Wang, Y1
Zhan, Z1
Ye, Y1
Qiu, Q1
Xu, H1
Liang, L1
Yang, X1
Ahmed, WM1
Khalaf, AA1
Moselhy, WA1
Safwat, GM1
Kopylov, U1
Amre, D1
Theoret, Y1
Deslandres, C1
Seidman, EG2
Vo, HD1
Xu, J1
Rabinowitz, SS1
Fisher, SE1
Schwarz, SM1
Trabelsi, AB1
Hamami, E1
Souguir, A1
Ksiaa, M1
Ajmi, S1
Jmaa, A1
Chertoff, J1
Alam, S1
Black, M1
Elgendy, IY1
Cheng, R1
Cooper, A1
Kench, J1
Watson, G1
Bye, W1
McNeil, C1
Shackel, N1
Goldberg, R1
Irving, PM2
Schröder, T1
Schmidt, KJ1
Olsen, V1
Möller, S1
Mackenroth, T1
Sina, C1
Lehnert, H1
Fellermann, K1
Büning, J1
Lin, KM1
Cheng, TT1
Lin, JC1
Chen, CJ1
Salvado, M1
Vargas, V1
Vidal, M1
Simon-Talero, M1
Camacho, J1
Gamez, J1
Thiel, C1
Cordes, H1
Conde, I1
Castell, JV1
Blank, LM1
Kuepfer, L1
Pavlidis, P1
Stamoulos, P1
Abdulrehman, A1
Kerr, P1
Bull, C1
Duley, J1
Ansari, A1
Jack, KL1
Koopman, WJ1
Hulley, D1
Nicolle, MW1
Björnsson, ES1
Gu, J1
Kleiner, DE1
Chalasani, N1
Hayashi, PH1
Hoofnagle, JH1
Coenen, MJ1
Derijks, LJ4
Vermeulen, SH1
Franke, B1
Engels, LG2
Verbeek, AL1
Leong, RW1
Gearry, RB4
Sparrow, MP1
Gardiner, SJ1
Burt, MJ1
Ding, SL1
Barclay, ML2
Kiefer, K1
El-Matary, W1
Xin, HW1
Xiong, H1
Wu, XC1
Li, Q1
Xiong, L1
Yu, AR1
Martínez-Odriozola, P1
Gutiérrez-Macías, A1
Ibarmia-Lahuerta, J1
Muñóz-Sánchez, J1
Takatsu, N1
Matsui, T1
Murakami, Y1
Ishihara, H1
Hisabe, T1
Nagahama, T1
Maki, S1
Beppu, T1
Takaki, Y1
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Mohd Mustapa, MF1
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Martelossi, S1
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Lionetti, P1
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Malusà, N1
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Giraldi, T1
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Aguas, M1
Beltrán, B1
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Zelinkova, Z1
Stokkers, PC1
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van Kampen, AH1
Curvers, WL1
Cohn, D1
van Deventer, SJ1
Hommes, DW1
Wu, YT1
Shen, C1
Yin, J1
Yu, JP1
Meng, Q1
Soto-Fernández, S1
González-Carro, P1
De Pedro-Esteban, A1
Legaz-Huidobro, ML1
Pérez-Roldán, F1
Roncero García-Escribano, O1
Valbuena-González, M1
Ruiz-Carrillo, F1
González-Lama, Y2
Maté, J2
Ooi, CY1
Bohane, TD1
Lee, D1
Naidoo, D1
Day, AS1
Luna, M1
Pousa, ID1
Velasco, M1
Moreno-Otero, R1
Shaye, OA1
Yadegari, M1
Abreu, MT2
Poordad, F1
Simon, K1
Martin, P1
Papadakis, KA1
Ippoliti, A1
Vasiliauskas, E1
Tran, TT1
Hartmann, U1
Schmitt, S1
Reuss-Borst, M1
Teruel, JL1
Marcén, R1
Celma, ML1
Bueno, R1
Jiménez del Cerro, L1
Matesanz, R1
Quereda, C1
Ortuño, J1
Cohen, DJ1
Loertscher, R1
Rubin, MF1
Tilney, NL2
Carpenter, CB2
Strom, TB2
Milford, EL1
Araujo, JL1
Kirkman, RL1
Eisenhauer, T1
Hartmann, H1
Rumpf, KW1
Helmchen, U1
Scheler, F1
Creutzfeldt, W1
Harvey, C1
Dixon, JS1
Bird, HA1
Aprosina, ZG1
Obata, T1
Watanabe, A3
Hayashi, S1
Higashi, T1
Endo, H2
Nagashima, H3
Horimi, T1
Huchimoto, S1
Sakagami, K1
Orita, K1
Kusaba, R1
Otubo, O1
Sugimoto, H1
Takahashi, I1
Yamada, Y1
Yamauchi, J1
Akiyama, N1
Inou, T1
Klintmalm, GB1
Iwatsuki, S1
Starzl, TE2
Whisnant, JK1
Pelkey, J1
Jazzar, A1
Fagiuoli, S1
Caraceni, P1
Deal, S1
Wright, HI1
Sisson, S1
Gavaler, J1
Van Thiel, DH1
Zuhdi, N1
Cooper, DK1
Gross, R1
Pol, S1
Cavalcanti, R1
Carnot, F1
Legendre, C1
Driss, F1
Chaix, ML1
Thervet, E1
Chkoff, N1
Brechot, C1
Berthelot, P1
Kreis, H2
de la Serna Higuera, C1
Moreira Vicente, VE1
Sanz de Villalobos, E1
Dubost, JJ1
Abergel, A1
Soubrier, M1
Bommelaer, G1
Sauvezie, B1
Aguilar, HI1
Burgart, LJ1
Geller, A1
Rakela, J1
Farrell, GC1
Pittau, S1
Morelli, S1
Venturini, E1
Boldorini, R1
Sartori, M1
Sun, C1
Qu, Z1
Hao, J1
Wang, J1
Roland, S1
Delwaide, J1
Cornet, G1
Mahieu, P1
Jacquet, N1
Belaiche, J1
Delgado, J1
Muñoz de Bustillo, E1
Ibarrola, C1
Colina, F1
Morales, JM1
Rodriguez, E1
Aguado, JM1
Fuertes, A1
Gomez, MA1
Castiglione, F1
Del Vecchio Blanco, G1
Rispo, A1
Cozzolino, A1
Di Girolamo, E1
Cappuccio, D1
Mazzacca, G1
del Valle García Sánchez, M1
Poyato González, A1
Gómez Camacho, F1
Luisa Vignote Alguacil, M1
Lytton, SD1
Berg, U1
Nemeth, A1
Ingelman-Sundberg, M1
Dubinsky, MC1
Yang, H1
Hassard, PV1
Kam, LY1
Targan, SR1
Vasiliauskas, EA1
Köttgen, E1
Gerok, W1
Hobara, N2
Rassner, G1
Schein, PS1
Winokur, SH1
Ware, AJ1
Luby, JP1
Eigenbrodt, EH1
Long, DL1
Hull, AR1
Berne, TV1
Chatterjee, SN1
Craig, JR1
Payne, JE1
Sopko, J1
Anuras, S1
Mozes, MF1
Ascher, NL1
Balfour, HH1
Simmons, RL1
Najarian, JS1
Tobe, K1
Knoblauch, M2
Andreu, J1
Caralps, A1
Brulles, A1
Lloveras, J1
Masramon, J1
Gil-Vernet, JM1
Hess, F1
Jerusalem, C1
Polak, M1
Barbanel, C1
Crosnier, J1
Sherlock, S2
Marubbio, AT1
Danielson, B1
Lämmli, J1
Funk, C1
Pickering, RW1
Lynn James, GW1
Parker, FL1
Meys, E1
Devogelaer, JP1
Geubel, A1
Rahier, J1
Nagant de Deuxchaisnes, C1
García, R1
Marín, C1
Herrera, J1
Henríquez La Roche, C1
Rubio, L1
Rodríguez-Iturbe, B1
Urowitz, MB1
Lee, P1
Jeurissen, ME1
Boerbooms, AM1
van de Putte, LB1
Kruijsen, MW1
Small, P1
Lichter, M1
Clements, PJ1
Davis, J1
Sandrini, S1
Scolari, F1
Savoldi, S1
Brunori, G1
Callea, F1
Tardanico, R1
Facchetti, F1
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Cristinelli, L1
Maiorca, R1
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De Pauw, L1
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Moreno Otero, R1
García Sánchez, A1
González Estecha, A1
Pajares, JM1
Gerlag, PG2
van Hooff, JP2
Wakabayashi, T1
Mori, S1
Pastolero, J1
Sugimura, H1
Katzka, DA1
Saul, SH1
Jorkasky, D1
Sigal, H1
Reynolds, JC1
Soloway, RD1
Cooper, C1
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Minihane, N1
Cawley, MI1
Opedal, I1
Ritland, S1
Elgjo, K1
Lobatto, S1
Driessen, WM1
Deckers, PF1
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Assmann, KM1
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Greif, J1
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Barrowman, JA1
Kutty, PK1
Ra, MU1
Huang, SN1
Aronsen, KF2
Husberg, B2
Hägerstrand, I1
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Pihl, B2
Baumann, W1
Götzel, L1
Mertens, HG1
Balzereit, F1
Leipert, M1
Malekzadeh, MH1
Grushkin, CM1
Wright, HT1
Fine, RN1
Fung, WP1
Zarday, Z1
Veith, FJ1
Gliedman, ML1
Soberman, R1
McNicol, GP1
Davies, JA1
Klatskin, G1
Kantor, FS1
Putnam, CW1
Ross, RC1
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Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacogenetic Testing in the Clinical Setting: is Screening for TPMT Genotype a Cost-effective Treatment Strategy? - The First Prospective Randomized Controlled Trial Within the Dutch Health Care System.[NCT00521950]853 participants (Actual)Interventional2007-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

23 reviews available for azathioprine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
The liver in pediatric gastrointestinal disease.
    Journal of pediatric gastroenterology and nutrition, 2014, Volume: 59, Issue:3

    Topics: Adolescent; Antibodies, Monoclonal; Azathioprine; Celiac Disease; Chemical and Drug Induced Liver In

2014
Azathioprine-induced hepatitis and cholestasis occurring 1 year after treatment.
    BMJ case reports, 2014, Dec-03, Volume: 2014

    Topics: Administration, Oral; Azathioprine; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Cholesta

2014
Ipilimumab-induced toxicities and the gastroenterologist.
    Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:4

    Topics: Antibodies, Monoclonal; Azathioprine; Calcineurin Inhibitors; Chemical and Drug Induced Liver Injury

2015
Toxicity and response to thiopurines in patients with inflammatory bowel disease.
    Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:7

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn Disease; Humans; Im

2015
Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:5

    Topics: Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug;

2008
Azathioprine-induced liver injury in a patient with multiple autoimmune syndrome.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:6

    Topics: Adult; Autoimmune Diseases; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerativ

2010
Mitochondrial and immunoallergic injury increase risk of positive drug rechallenge after drug-induced liver injury: a systematic review.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:6

    Topics: Amoxicillin-Potassium Clavulanate Combination; Antitubercular Agents; Azathioprine; Chemical and Dru

2010
Thiopurine-induced liver injury in patients with inflammatory bowel disease: a systematic review.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:7

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Chemical and Drug Induced Liver Injury; Global Health

2007
Cyclosporine: a new immunosuppressive agent for organ transplantation.
    Annals of internal medicine, 1984, Volume: 101, Issue:5

    Topics: Animals; Azathioprine; Bone Marrow Transplantation; Chemical and Drug Induced Liver Injury; Cyclospo

1984
[Diagnosis and treatment of chronic active hepatitis].
    Klinicheskaia meditsina, 1984, Volume: 62, Issue:9

    Topics: Adrenal Cortex Hormones; Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Hepa

1984
Drug-induced hepatic injury.
    Journal of gastroenterology and hepatology, 1997, Volume: 12, Issue:9-10

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Aza

1997
[Severe acute hepatitis caused by azathioprine].
    Medicina clinica, 2001, Jun-16, Volume: 117, Issue:2

    Topics: Acute Disease; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Immunosuppressiv

2001
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
    Annals of internal medicine, 1975, Volume: 82, Issue:1

    Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical a

1975
Liver disease in renal transplant recipients.
    The American journal of medicine, 1978, Volume: 64, Issue:1

    Topics: Animals; Azathioprine; Budd-Chiari Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Ch

1978
[Drug induced liver disease (author's transl)].
    Therapeutische Umschau. Revue therapeutique, 1978, Volume: 35, Issue:9

    Topics: Azathioprine; Bile Acids and Salts; Bilirubin; Biotransformation; Chemical and Drug Induced Liver In

1978
The risks of antimalarial retinopathy, azathioprine lymphoma and methotrexate hepatotoxicity during the treatment of rheumatoid arthritis.
    Bailliere's clinical rheumatology, 1990, Volume: 4, Issue:2

    Topics: Antimalarials; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Humans;

1990
Cytotoxic drugs: their clinical application to the rheumatic diseases.
    Seminars in arthritis and rheumatism, 1986, Volume: 15, Issue:4

    Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica

1986
[Liver disease caused by azathioprine: clinical case and review of the literature].
    Revista espanola de las enfermedades del aparato digestivo, 1988, Volume: 73, Issue:2

    Topics: Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Leukopenia; Liver Diseases; Male

1988
Advances in medicine.
    The Practitioner, 1972, Volume: 209, Issue:252

    Topics: Anemia, Macrocytic; Anti-Arrhythmia Agents; Anticoagulants; Azathioprine; Chemical and Drug Induced

1972
Treatment of liver disease with corticosteroids.
    The Medical clinics of North America, 1973, Volume: 57, Issue:5

    Topics: Adrenal Cortex Hormones; Alcoholism; Azathioprine; Chemical and Drug Induced Liver Injury; Glucocort

1973
Chronic hepatitis.
    Gut, 1974, Volume: 15, Issue:7

    Topics: Adult; Animals; Autoimmune Diseases; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Ch

1974
Therapeutic considerations in selected forms of acute and chronic liver disease.
    The Medical clinics of North America, 1971, Volume: 55, Issue:2

    Topics: Acute Disease; Age Factors; Alcoholism; Azathioprine; Chemical and Drug Induced Liver Injury; Chroni

1971

Trials

7 trials available for azathioprine and Acute Liver Injury, Drug-Induced

ArticleYear
More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.
    Inflammatory bowel diseases, 2017, Volume: 23, Issue:10

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Inflammatory Bowel Dise

2017
Early prediction of thiopurine-induced hepatotoxicity in inflammatory bowel disease.
    Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort Studies

2017
6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment.
    European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:1

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug

2003
Experience with cyclosporine and steroids in clinical renal transplantation.
    Annals of surgery, 1984, Volume: 200, Issue:5

    Topics: Actuarial Analysis; Adult; Azathioprine; Cadaver; Chemical and Drug Induced Liver Injury; Clinical T

1984
Incidence and etiology of hepatic dysfunction in heart transplant recipients receiving a cyclosporine-based triple immunosuppressive therapy.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Follo

1994
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
    Gastroenterology, 2002, Volume: 122, Issue:4

    Topics: Adolescent; Adult; Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Resistance; Fema

2002
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
    Clinical chemistry, 2007, Volume: 53, Issue:7

    Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Crohn Disease; Dose-Response Relati

2007

Other Studies

141 other studies available for azathioprine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Effect of gervital in attenuating hepatotoxicity caused by methotrexate or azathioprine in adult albino rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:31

    Topics: Animals; Antioxidants; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced Liver In

2022
Prevalence of hepatotoxicity and myelosuppression with alternate day use of azathioprine and glucocorticoids for treatment of dermatological conditions in dogs.
    Veterinary dermatology, 2022, Volume: 33, Issue:6

    Topics: Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Glucocorticoids;

2022
Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients.
    Therapeutic drug monitoring, 2022, 12-01, Volume: 44, Issue:6

    Topics: Algorithms; Azathioprine; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adve

2022
Severe azathioprine-induced liver injury 22 months after initiation of treatment.
    BMJ case reports, 2022, Dec-21, Volume: 15, Issue:12

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chroni

2022
Liver steatosis is a risk factor for hepatotoxicity in inflammatory bowel disease patients treated with azathioprine.
    European journal of gastroenterology & hepatology, 2020, Volume: 32, Issue:10

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Fatty Liver; Humans; Inflammatory Bowel Diseas

2020
Infliximab Was Found to Be Effective for Treating Immunosuppressive Drug-resistant Hepatitis due to Durvalumab.
    Internal medicine (Tokyo, Japan), 2020, Dec-01, Volume: 59, Issue:23

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents, Immunological; Azathioprine; Carcinoma, Non-Sma

2020
Clinical and histologic features of Azathioprine-induced hepatotoxicity.
    Scandinavian journal of gastroenterology, 2017, Volume: 52, Issue:8

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Azathioprine; Bilirubin; Chemical and Drug Induce

2017
Azathioprine combination therapy for steroid-refractory hepatic immune system-related adverse events.
    European journal of dermatology : EJD, 2017, 06-01, Volume: 27, Issue:3

    Topics: Aged; Antibodies, Monoclonal; Antineoplastic Agents; Azathioprine; Chemical and Drug Induced Liver I

2017
Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study.
    World journal of gastroenterology, 2017, Jun-14, Volume: 23, Issue:22

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Chemical and Drug Induced Liver Injury; Chi-Square Di

2017
Low-dose thiopurine with allopurinol co-therapy overcomes thiopurine intolerance and allows thiopurine continuation in inflammatory bowel disease.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2018, Volume: 50, Issue:7

    Topics: Adolescent; Adult; Aged; Allopurinol; Australia; Azathioprine; Chemical and Drug Induced Liver Injur

2018
NUDT15 polymorphism identified in a patient with azathioprine hypersensitivity syndrome presenting as erythema nodosum and hepatotoxicity.
    The British journal of dermatology, 2019, Volume: 181, Issue:3

    Topics: Adult; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Chronic Urticaria; Erythema Nod

2019
Severe cholestasis due to azathioprine in Behcet's disease.
    BMJ case reports, 2019, Mar-31, Volume: 12, Issue:3

    Topics: Adult; Azathioprine; Behcet Syndrome; Chemical and Drug Induced Liver Injury; Cholestasis; Humans; I

2019
Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate.
    Internal medicine (Tokyo, Japan), 2019, Sep-01, Volume: 58, Issue:17

    Topics: Adolescent; Antiviral Agents; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Guanidin

2019
[Azathioprine-induced hepatotoxicity in a patient with Crohn's disease].
    Anales del sistema sanitario de Navarra, 2013, Sep-06, Volume: 36, Issue:2

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Humans; Immunosuppressiv

2013
Involvement of oxidative stress and immune- and inflammation-related factors in azathioprine-induced liver injury.
    Toxicology letters, 2014, Jan-13, Volume: 224, Issue:2

    Topics: Animals; Azathioprine; Carrier Proteins; Chemical and Drug Induced Liver Injury; Female; Glutathione

2014
Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus.
    Clinical rheumatology, 2014, Volume: 33, Issue:4

    Topics: Adult; Alleles; Alopecia; Asian People; Azathioprine; Chemical and Drug Induced Liver Injury; Cohort

2014
Royal jelly attenuates azathioprine induced toxicity in rats.
    Environmental toxicology and pharmacology, 2014, Volume: 37, Issue:1

    Topics: Alanine Transaminase; Alkaline Phosphatase; Anemia; Animals; Antimetabolites, Antineoplastic; Aspart

2014
Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease.
    Journal of pediatric gastroenterology and nutrition, 2014, Volume: 59, Issue:4

    Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Crohn Disease; Female; Guan

2014
Suspected azathioprine induced liver cirrhosis: an unusual side effect.
    The Pan African medical journal, 2014, Volume: 17

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Immunosuppressive Agents; Live

2014
Liver steatosis is a risk factor for hepatotoxicity in patients with inflammatory bowel disease under immunosuppressive treatment.
    European journal of gastroenterology & hepatology, 2015, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Aspartate Aminotransferases; Azathioprin

2015
Tumor necrosis factor-α antagonist therapy for concomitant rheumatoid arthritis and hepatitis C virus infection: a case series study.
    Clinical rheumatology, 2015, Volume: 34, Issue:6

    Topics: Adalimumab; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumato

2015
Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient.
    World journal of gastroenterology, 2015, Sep-28, Volume: 21, Issue:36

    Topics: Adult; Amyotrophic Lateral Sclerosis; Azathioprine; Benzamides; Biopsy; Chemical and Drug Induced Li

2015
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.
    Archives of toxicology, 2017, Volume: 91, Issue:2

    Topics: Adult; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Si

2017
Long-term Safety and Efficacy of Low-dose Azathioprine and Allopurinol Cotherapy in Inflammatory Bowel Disease: A Large Observational Study.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Antimetabolites; Azathioprine; Blood Sedime

2016
A Review of Azathioprine-Associated Hepatotoxicity and Myelosuppression in Myasthenia Gravis.
    Journal of clinical neuromuscular disease, 2016, Volume: 18, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans

2016
Azathioprine and 6-Mercaptopurine-induced Liver Injury: Clinical Features and Outcomes.
    Journal of clinical gastroenterology, 2017, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Azathioprine; Bilirubin; Chemic

2017
Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.
    European journal of gastroenterology & hepatology, 2008, Volume: 20, Issue:12

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Moni

2008
6-mercaptopurine as an alternative to azathioprine in azathioprine-induced hepatoxicity.
    Inflammatory bowel diseases, 2009, Volume: 15, Issue:2

    Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Crohn Disease; Humans; Immu

2009
Relationships between thiopurine S-methyltransferase polymorphism and azathioprine-related adverse drug reactions in Chinese renal transplant recipients.
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:3

    Topics: Adult; Aged; Asian People; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relat

2009
Meloxicam as a cause of drug-induced autoimmune hepatitis.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:4

    Topics: Actin Cytoskeleton; Alanine Transaminase; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-St

2010
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:7

    Topics: Adult; Alopecia; Aminosalicylic Acids; Anti-Inflammatory Agents; Asian People; Azathioprine; Chemica

2009
Mercaptopurine rescue after azathioprine-induced liver injury in inflammatory bowel disease.
    Alimentary pharmacology & therapeutics, 2010, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn

2010
[Hepatotoxicity induced by new immunosuppressants].
    Gastroenterologia y hepatologia, 2010, Volume: 33, Issue:1

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporine; Humans; Immunosuppressive Agents

2010
Azathioprine-induced hypersensitivity hepatitis: tolerance to 6-mercaptopurine.
    Inflammatory bowel diseases, 2010, Volume: 16, Issue:11

    Topics: Acute Disease; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Drug Hyper

2010
Nodular regenerative hyperplasia of the liver secondary to azathioprine in a patient with inflammatory bowel disease.
    The New Zealand medical journal, 2010, Apr-30, Volume: 123, Issue:1313

    Topics: Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Crohn Disease; Diagnosis, Differential

2010
Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease.
    Immunopharmacology and immunotoxicology, 2011, Volume: 33, Issue:2

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Female; Humans; Hyperpla

2011
Allopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?
    Pharmacogenomics, 2010, Volume: 11, Issue:11

    Topics: Allopurinol; Azathioprine; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Therapy,

2010
[Nodular regenerative hyperplasia: azathioprine-induced hepatotoxicity in a patient with Crohn's disease].
    Gastroenterologia y hepatologia, 2011, Volume: 34, Issue:1

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Humans; Hyperplasia; Hypertensi

2011
Azathioprine induced hepatitis in patients with inflammatory bowel disease.
    International journal of clinical pharmacy, 2011, Volume: 33, Issue:5

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Immunosuppressive Agents; Inflammatory

2011
British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011.
    The British journal of dermatology, 2011, Volume: 165, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Bone Marrow Diseases; Chemical and Drug Indu

2011
Ornidazole-induced autoimmune hepatitis.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2011, Volume: 22, Issue:5

    Topics: Adult; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Fema

2011
Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment.
    Journal of Crohn's & colitis, 2012, Volume: 6, Issue:1

    Topics: Antimetabolites, Antineoplastic; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Human

2012
Optimising outcome on thiopurines in inflammatory bowel disease by co-prescription of allopurinol.
    Journal of Crohn's & colitis, 2012, Volume: 6, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; C

2012
Azathioprine induced liver injury: a case report.
    Digestive diseases and sciences, 2012, Volume: 57, Issue:6

    Topics: Azathioprine; Biopsy, Needle; Body Mass Index; Chemical and Drug Induced Liver Injury; Dermatitis; F

2012
A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol.
    Journal of Crohn's & colitis, 2013, Volume: 7, Issue:6

    Topics: Adult; Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship

2013
A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 134, Issue:4

    Topics: Acetylcysteine; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combina

2003
Side effects of azathioprine in patients with Crohn's disease.
    European journal of gastroenterology & hepatology, 2004, Volume: 16, Issue:2

    Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents; Azathioprine; Chemical and Drug Induced Liver In

2004
Severe cholestatic hepatitis caused by azathioprine.
    Immunopharmacology and immunotoxicology, 2005, Volume: 27, Issue:1

    Topics: Aged; Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Humans; Liver

2005
Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats.
    Life sciences, 2005, Jun-03, Volume: 77, Issue:3

    Topics: Animals; Antimetabolites; Antioxidants; Azathioprine; Chemical and Drug Induced Liver Injury; Hibisc

2005
TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2005, Volume: 37, Issue:12

    Topics: Adolescent; Adult; Azathioprine; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child

2005
Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease.
    Alimentary pharmacology & therapeutics, 2005, Nov-01, Volume: 22, Issue:9

    Topics: Adolescent; Adult; Aged; Azathioprine; Biomarkers; Chemical and Drug Induced Liver Injury; Female; H

2005
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2006, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Chemical and Drug Induced Liver Injury; Cr

2006
6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: dose or level dependent?
    Journal of hepatology, 2006, Volume: 44, Issue:4

    Topics: Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug

2006
Azathioprine hepatotoxicity and the protective effect of liquorice and glycyrrhizic acid.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:8

    Topics: Acetylcysteine; Animals; Azathioprine; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liv

2006
[Infliximab-induced hepatitis in a patient with Crohn's disease].
    Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:5

    Topics: Acute Disease; Adult; Antibodies, Monoclonal; Azathioprine; Chemical and Drug Induced Liver Injury;

2006
Thiopurine metabolite monitoring in paediatric inflammatory bowel disease.
    Alimentary pharmacology & therapeutics, 2007, Apr-15, Volume: 25, Issue:8

    Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hype

2007
Liver injury in inflammatory bowel disease: long-term follow-up study of 786 patients.
    Inflammatory bowel diseases, 2007, Volume: 13, Issue:9

    Topics: Adult; Algorithms; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Female

2007
Hepatotoxicity of 6-mercaptopurine (6-MP) and Azathioprine (AZA) in adult IBD patients.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Azathioprine; Chemical and Drug Induced Liver Injur

2007
[Elevated liver enzymes in rheumatoid arthritis : differential diagnostic considerations based on a case report].
    Zeitschrift fur Rheumatologie, 2008, Volume: 67, Issue:5

    Topics: Adalimumab; Adolescent; Alanine Transaminase; Antibodies, Monoclonal; Antibodies, Monoclonal, Humani

2008
[Hepatopathy in kidney transplant patients: incidence, etiology and clinical forms of presentation].
    Medicina clinica, 1984, May-12, Volume: 82, Issue:18

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Cytomegalovirus Inf

1984
Favourable outcome of hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine, treated by portacaval shunt. Report of a case and review of the literature.
    Digestion, 1984, Volume: 30, Issue:3

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Constriction, Pathologic; Hepatic Veins; Human

1984
Serum IgA concentration and hepatotoxicity in rheumatoid arthritis treated with azathioprine.
    British medical journal (Clinical research ed.), 1983, Aug-20, Volume: 287, Issue:6391

    Topics: Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Immunog

1983
[Liver injury in kidney transplant patients receiving azathioprine (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1980, Volume: 77, Issue:1

    Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Azathioprine; Chemical and Drug Induced Liver Inj

1980
Immunosuppressive effect of bredinin in the management of patients with renal transplantation.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1981, Volume: 18

    Topics: Adolescent; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Graft Rejection; Hu

1981
Cyclosporin A hepatotoxicity in 66 renal allograft recipients.
    Transplantation, 1981, Volume: 32, Issue:6

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporins; Dose-Response Relationship, Drug

1981
Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities.
    Annals of the rheumatic diseases, 1982, Volume: 41 Suppl 1

    Topics: Adult; Aged; Anorexia; Arthritis, Rheumatoid; Azathioprine; Bacterial Infections; Chemical and Drug

1982
Hepatotoxicity of 6-mercaptopurine and azathioprine.
    Mayo Clinic proceedings, 1994, Volume: 69, Issue:5

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Liver; Mercaptopurine

1994
Azathioprine hepatitis in kidney transplant recipients. A predisposing role of chronic viral hepatitis.
    Transplantation, 1996, Jun-27, Volume: 61, Issue:12

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Enzyme-Linked Immunoso

1996
[Mixed hepatitis induced by azathioprine].
    Medicina clinica, 1996, Dec-07, Volume: 107, Issue:20

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Immunosuppressive Agent

1996
[Acute cytolytic hepatitis in azathioprine hypersensitivity].
    Gastroenterologie clinique et biologique, 1996, Volume: 20, Issue:10

    Topics: Acute Disease; Adult; Antirheumatic Agents; Azathioprine; Behcet Syndrome; Chemical and Drug Induced

1996
Azathioprine-induced lymphoma manifesting as fulminant hepatic failure.
    Mayo Clinic proceedings, 1997, Volume: 72, Issue:7

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; F

1997
[Post-infantile giant cell hepatitis. Clinical and histological response to immunosuppressive therapy].
    Recenti progressi in medicina, 1998, Volume: 89, Issue:3

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Fibrinolytic Agents; Glucocorticoids; H

1998
[Protective effects of radix Salviae miltiorrhizae on azathioprine hepatotoxicity in rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1996, Volume: 21, Issue:8

    Topics: Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Female; Free R

1996
[Clinical case of the month. Hepatoportal sclerosis in a patient treated with azathioprine].
    Revue medicale de Liege, 1998, Volume: 53, Issue:8

    Topics: Adult; Ascites; Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis; Diagnosis, Differ

1998
Hepatitis C virus-related fibrosing cholestatic hepatitis after cardiac transplantation: is azathioprine a contributory factor?
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:6

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Fatal Outcome; Hear

1999
Hepatitis related to cytomegalovirus infection in two patients with Crohn's disease treated with azathioprine.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2000, Volume: 32, Issue:7

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Crohn Disease; Cytomegalovirus Infectio

2000
Autoantibodies against cytochrome P450s in sera of children treated with immunosuppressive drugs.
    Clinical and experimental immunology, 2002, Volume: 127, Issue:2

    Topics: Adolescent; Adult; Antibody Specificity; Aryl Hydrocarbon Hydroxylases; Autoantibodies; Autoantigens

2002
[Isoenzyme differentiation of gamma-glutamyltransferase by concanavalin A and Con- A-Sepharose (author's transl)].
    Klinische Wochenschrift, 1976, May-01, Volume: 54, Issue:9

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Chemical Precipitation; Chromatography, Affini

1976
[Biochemical and morphological study on hepato-toxicity of azathioprine in rat (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1979, Volume: 76, Issue:9

    Topics: Alkaline Phosphatase; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; gamma-Glutamylt

1979
[Practical aspects of the cytostatic therapy of psoriasis].
    Zeitschrift fur Hautkrankheiten, 1976, Jun-15, Volume: 51, Issue:12

    Topics: Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Chemical and Drug Induced Liver Injury; Hu

1976
Spectrum of liver disease in renal transplant recipients.
    Gastroenterology, 1975, Volume: 68, Issue:4 Pt 1

    Topics: Acute Disease; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; Cytomegalovirus; Hep

1975
Hepatic dysfunction in recipients of renal allografts.
    Surgery, gynecology & obstetrics, 1975, Volume: 141, Issue:2

    Topics: Alanine Transaminase; Alkaline Phosphatase; Antigens, Viral; Aspartate Aminotransferases; Azathiopri

1975
Jaundice after renal allotransplantation.
    Annals of surgery, 1978, Volume: 188, Issue:6

    Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Transfusion

1978
Biochemical and morphological study on hepatotoxicity of azathioprine in rat.
    Acta medica Okayama, 1979, Volume: 33, Issue:1

    Topics: Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Glucose-6-Phos

1979
Cyclophosphamide (CP) substituting azathioprine after renal transplantation.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1976, Volume: 12

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Graft Rejection; Humans; Imm

1976
Azathioprine hepatotoxicity, direct complication or secondary effect in rat liver transplantation.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1976, Volume: 8, Issue:2

    Topics: Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Hepatectomy; Hepatic Artery; Liver; L

1976
[Long-term use of immunosuppressants in patients with kidney transplants].
    Annales de medecine interne, 1975, Volume: 126, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Gastro

1975
Diagnosis and treatment of chronic active hepatitis.
    Medical times, 1977, Volume: 105, Issue:4

    Topics: Adolescent; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; He

1977
Hepatic veno-occlusive disease in a renal transplant patient receiving azathioprine.
    Gastroenterology, 1975, Volume: 69, Issue:3

    Topics: Azathioprine; Budd-Chiari Syndrome; Chemical and Drug Induced Liver Injury; Humans; Kidney Transplan

1975
[Drug-induced liver diseases].
    Gastroenterologische Fortbildungskurse fur die Praxis, 1975, Volume: 5

    Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C

1975
Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced

1975
Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity.
    The Journal of rheumatology, 1992, Volume: 19, Issue:5

    Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury;

1992
[Usefulness of ketoconazole combined with cyclosporin in renal transplantation].
    Investigacion clinica, 1991, Volume: 32, Issue:3

    Topics: Adolescent; Adult; Azathioprine; Biotransformation; Chemical and Drug Induced Liver Injury; Cyclospo

1991
Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis.
    Annals of the rheumatic diseases, 1990, Volume: 49, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Eruptions; D

1990
Probable azathioprine hepatotoxicity: a case report.
    Annals of allergy, 1989, Volume: 62, Issue:6

    Topics: Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Humans; Liver; Male; Mi

1989
Liver disease in renal transplant patients treated with azathioprine or ciclosporin.
    Contributions to nephrology, 1986, Volume: 51

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclosporins; Cytomegalovirus Infections; Fema

1986
Hepatic vascular disease after kidney transplantation: report of two cases and review of the literature.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1987, Volume: 2, Issue:3

    Topics: Adult; Azathioprine; Biopsy; Chemical and Drug Induced Liver Injury; Hepatic Veins; Hepatic Veno-Occ

1987
Role of endothelial cell injury in the spectrum of azathioprine-induced liver disease after renal transplant: light microscopy and ultrastructural observations.
    The American journal of gastroenterology, 1988, Volume: 83, Issue:3

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Endothelium; Female; Hepatomegaly; Huma

1988
Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment: a cause of chronic liver disease after kidney transplantation.
    Transplantation proceedings, 1987, Volume: 19, Issue:5

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hypert

1987
Bile ductal and ductular changes of the livers in the renal allografted patients.
    Acta pathologica japonica, 1987, Volume: 37, Issue:8

    Topics: Adult; Azathioprine; Bile Ducts, Intrahepatic; Biopsy, Needle; Chemical and Drug Induced Liver Injur

1987
Azathioprine and hepatic venocclusive disease in renal transplant patients.
    Gastroenterology, 1986, Volume: 90, Issue:2

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Hepatic Veins; Humans; Immunosuppressio

1986
Azathioprine hypersensitivity manifesting as acute focal hepatocellular necrosis.
    Journal of the Royal Society of Medicine, 1986, Volume: 79, Issue:3

    Topics: Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity;

1986
Chronic active hepatitis. Experience from a Norwegian reference hospital during a decade.
    Scandinavian journal of gastroenterology. Supplement, 1985, Volume: 107

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Chemical and Drug Induced Liver Inju

1985
Hepatic sinusoidal dilatation with portal hypertension during azathioprine treatment after kidney transplantation.
    Journal of hepatology, 1985, Volume: 1, Issue:4

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Esophagus; Female; Humans; Hypertension

1985
[Life-threatening interaction between azathioprine and allopurinol].
    Der Internist, 1985, Volume: 26, Issue:11

    Topics: Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Therapy, Com

1985
Sclerosing hepatitis and azathioprine.
    Digestive diseases and sciences, 1986, Volume: 31, Issue:2

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Demyelinating Diseases; Humans; Male

1986
Management of chronic hepatitis.
    Lancet (London, England), 1971, Jun-12, Volume: 1, Issue:7711

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Hepatitis; Hepatitis

1971
Enzyme histochemical studies of the liver during immunosuppressive treatment in dogs.
    Acta chirurgica Scandinavica, 1970, Volume: 136, Issue:6

    Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Antilymphocyte Serum; Az

1970
[Diagnosis, therapy and clinical course in chronic active hepatitis in childhood with special reference to immunological findings (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1974, Volume: 122, Issue:12

    Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Azathioprine; Chemical and Drug Induced Liver Inju

1974
[Complications of immunosuppressive therapy using cytostatics in autoaggression diseases with special reference to cholestatic hepatosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1973, Jun-01, Volume: 28, Issue:11

    Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chemical and Drug Induced Liver Injury;

1973
The treatment of severe myasthenia gravis with immunosuppressive agents.
    European neurology, 1969, Volume: 2, Issue:6

    Topics: Adolescent; Adult; Age Factors; Agranulocytosis; Aminopterin; Azathioprine; Chemical and Drug Induce

1969
Hepatic dysfunction after renal transplantation in children.
    The Journal of pediatrics, 1972, Volume: 81, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Azathiop

1972
Clinical use of corticosteroid and immunosuppressive drugs in liver disease.
    Drugs, 1974, Volume: 8, Issue:2

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Biliary Tract Diseases; Chemical and D

1974
Irreversible liver damage after azathioprine.
    JAMA, 1972, Nov-06, Volume: 222, Issue:6

    Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Autopsy; Azathioprine; Chemical and Drug I

1972
Mitochondrial antibody in primary biliary cirrhosis and other diseases.
    Annals of internal medicine, 1972, Volume: 77, Issue:4

    Topics: Antibodies; Azathioprine; Biliary Tract Diseases; Biopsy; Chemical and Drug Induced Liver Injury; Ch

1972
Chronic immunosuppression, Australia antigenemia, and hepatitis.
    Transplantation proceedings, 1972, Volume: 4, Issue:4

    Topics: Animals; Azathioprine; Carrier State; Chemical and Drug Induced Liver Injury; Complement Fixation Te

1972
Ultrastructure of peliosis hepatis in a percutaneous biopsy.
    Pathologia Europaea, 1972, Volume: 7, Issue:3

    Topics: Azathioprine; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Heart T

1972
Liver disease in kidney transplant patients receiving azathioprine.
    Archives of internal medicine, 1973, Volume: 132, Issue:1

    Topics: Adolescent; Adult; Alkaline Phosphatase; Amylases; Aspartate Aminotransferases; Azathioprine; Biliru

1973
Letter: Isoniazid hepatotoxicity.
    Annals of internal medicine, 1973, Volume: 79, Issue:6

    Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Glomerulonephritis; Humans; Isoniazid;

1973
[Cyclophosphamide therapy in kidney transplants].
    Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1973, Volume: 54, Issue:4

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Chemical and Drug Induced Liver Injury; Cyclophosphamide;

1973
[Proceedings: Immunosuppression and treatment of psoriasis using cytostatic agents].
    Zeitschrift fur Hautkrankheiten, 1973, Dec-01, Volume: 48, Issue:23

    Topics: Aged; Antineoplastic Agents; Azathioprine; Bibliographies as Topic; Chemical and Drug Induced Liver

1973
Letter: Azathioprine and liver disease.
    Archives of internal medicine, 1974, Volume: 133, Issue:5

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Hepatitis A; Liver; Liver Transplantation

1974
[Cytostatic long-term therapy of rheumatoid arthritis].
    Verhandlungen der Deutschen Gesellschaft fur Rheumatologie, 1972, Volume: 2

    Topics: Administration, Oral; Arthritis, Rheumatoid; Azathioprine; Chemical and Drug Induced Liver Injury; C

1972
[Toxic lesions of the liver due to immunosuppressive agents].
    Ceskoslovenska gastroenterologie a vyziva, 1973, Volume: 27, Issue:8

    Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Humans

1973
Treatment of psoriasis with azathioprine.
    British medical journal, 1974, Jan-12, Volume: 1, Issue:5897

    Topics: Alcohol Drinking; Anemia; Azathioprine; Biopsy; Blood Cell Count; Chemical and Drug Induced Liver In

1974
[Liver lesions in patients following kidney transplantation].
    Sovetskaia meditsina, 1969, Volume: 32, Issue:8

    Topics: Adolescent; Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Female; Humans; Kidney Tran

1969
Coproporphyrinuria and heart transplantation: its significance.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1970, Sep-12, Volume: 44, Issue:36

    Topics: Age Factors; Anemia, Hemolytic; Azathioprine; Chemical and Drug Induced Liver Injury; Electrocardiog

1970
Acute massive hepatic necrosis with fatal liver failure.
    The American journal of digestive diseases, 1971, Volume: 16, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Anticonvulsants; Antitubercular Agents; Azathioprine; Blood

1971
Immunosuppressive treatment in non-transplanted dogs. Azathioprine versus azathioprine-antilymphocyteimmuno-globulin-G.
    Acta chirurgica Scandinavica, 1969, Volume: 135, Issue:6

    Topics: Anemia; Animals; Antibodies; Antilymphocyte Serum; Azathioprine; Chemical and Drug Induced Liver Inj

1969
Accentuation of carbon tetrachloride-induced cirrhosis by azathioprine in the rat.
    Archives of pathology, 1970, Volume: 90, Issue:6

    Topics: Animals; Azathioprine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chola

1970
Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease.
    Current drug safety, 2013, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Age Factors; Chemical and Drug Induced Liver Injury; Cohort Studies; Crohn Diseas

2013