azathioprine has been researched along with Abnormalities, Autosome in 39 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Efficacy and safety of azathioprine in 'high' and 'low' dose regimens in rheumatoid arthritis (RA), both in short-term studies and in follow-up over 40 months, have previously been shown." | 7.66 | Long-term effects of azathioprine in rheumatoid arthritis. ( Able, T; Norman, CS; Smythe, HA; Travis, C; Urowitz, MB, 1982) |
| "Treatment with azathioprine may - depending on its cumulative dosage - lead to pancytopenia and subsequent development of myelodysplasia or secondary leukaemia, respectively." | 3.72 | [Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations]. ( Kaiser, U; Schlegelberger, B; Wilkens, L; Willerding-Möllmann, S, 2004) |
| "A boy with microcephaly, unusual facial features, micropenis, and growth retardation was born to a 30-year-old woman who took azathioprine and prednisone before and during pregnancy for systemic lupus erythematosus." | 3.67 | Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone. ( Ostrer, H; Perinchief, P; Stamberg, J, 1984) |
| "Chromosomal analyses in lymphocytes of 28 patients with multiple sclerosis were carried out before, during and after Azathioprine (Aza) therapy." | 3.66 | Azathioprine, a clastogen in human somatic cells? Analysis of chromosome damage and SCE in lymphocytes after exposure in vivo and in vitro. ( Apelt, F; Bauchinger, M; Kolin-Gerresheim, J, 1981) |
| "Efficacy and safety of azathioprine in 'high' and 'low' dose regimens in rheumatoid arthritis (RA), both in short-term studies and in follow-up over 40 months, have previously been shown." | 3.66 | Long-term effects of azathioprine in rheumatoid arthritis. ( Able, T; Norman, CS; Smythe, HA; Travis, C; Urowitz, MB, 1982) |
| "In chromosomes of peripheral lymphocytes of 35 patients with multiple sclerosis treated with azathioprine, antilymphocytic globulin or thoracic-duct drainage structural aberrations (breaks and gaps) were found at a significantly high rate." | 3.65 | [Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)]. ( Angstwurm, H; Frick, E; Ring, J; Stickl, H; Unglaub-Leisten, I, 1975) |
| " In terms of reproductive and developmental toxicity, cyclosporine produces some adverse effects in both experimental animals and humans." | 2.39 | International Commission for Protection Against Environmental Mutagens and Carcinogens. Cyclosporine A: review of genotoxicity and potential for adverse human reproductive and developmental effects. Report of a Working Group on the genotoxicity of cyclosp ( Mattison, DR; Olshan, AF; Zwanenburg, TS, 1994) |
| "The treatment with azathioprine in a dose of 1." | 1.28 | [Chromosome aberration levels and their dynamics during the treatment with cytotoxic preparations of patients with primary and lupus glomerulonephritis]. ( Bagriĭ, AE; Diadyk, AI; Efremenko, VA; Iarovaia, NF; Nikolenko, IuI; Nikolenko, VIu; Siniachenko, OV; Sokhin, AA, 1991) |
| " The correlation between these is poor, in many patients, at the dosage used in man." | 1.26 | The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens. ( Hazleman, BL, 1982) |
| "Azathioprine has been associated with chromosome abnormalities." | 1.26 | Erythroleukemia in a renal transplant recipient. ( Baker, MA; deVeber, GA; Ellerton, JA, 1979) |
| "2." | 1.25 | [Induction of chromosome aberrations by antirheumatic therapy]. ( Vormittag, W, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (84.62) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 3 (7.69) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mullier, F | 1 |
| Rahier, JF | 1 |
| Maignen, F | 1 |
| Cornet, Y | 1 |
| Graux, C | 1 |
| Chatelain, C | 1 |
| Chatelain, B | 1 |
| Dogne, JM | 1 |
| Navarro, JT | 1 |
| Ribera, JM | 1 |
| Mate, JL | 1 |
| Granada, I | 1 |
| Juncà, J | 1 |
| Batlle, M | 1 |
| Millá, F | 1 |
| Feliu, E | 1 |
| Depil, S | 1 |
| Lepelley, P | 1 |
| Soenen, V | 1 |
| Preudhomme, C | 1 |
| Lai, JL | 1 |
| Broly, F | 1 |
| Quesnel, B | 1 |
| Willerding-Möllmann, S | 1 |
| Wilkens, L | 1 |
| Schlegelberger, B | 1 |
| Kaiser, U | 1 |
| Jensen, MK | 4 |
| Apelt, F | 1 |
| Kolin-Gerresheim, J | 1 |
| Bauchinger, M | 1 |
| Urowitz, MB | 1 |
| Smythe, HA | 1 |
| Able, T | 1 |
| Norman, CS | 1 |
| Travis, C | 1 |
| Ostrer, H | 1 |
| Stamberg, J | 1 |
| Perinchief, P | 1 |
| Hazleman, BL | 1 |
| Kucerová, M | 1 |
| Kocandrle, V | 1 |
| Matousek, V | 1 |
| Polívková, Z | 1 |
| Reneltová, I | 1 |
| Matter, BE | 1 |
| Donatsch, P | 1 |
| Racine, RR | 1 |
| Schmid, B | 1 |
| Suter, W | 1 |
| Olshan, AF | 1 |
| Mattison, DR | 1 |
| Zwanenburg, TS | 1 |
| Mathies, H | 1 |
| Ellerton, JA | 1 |
| deVeber, GA | 1 |
| Baker, MA | 1 |
| Paufler, S | 2 |
| Laerum, A | 1 |
| Michelmann, HW | 2 |
| Seidenkranz, HG | 2 |
| Geldermann, H | 1 |
| Perings, E | 3 |
| Smidt, D | 2 |
| Van Went, GF | 1 |
| Price, HV | 1 |
| Salaman, JR | 1 |
| Laurence, KM | 1 |
| Langmaid, H | 1 |
| Hüttel, MS | 1 |
| Madle, S | 1 |
| Nowak, J | 1 |
| Obe, G | 1 |
| Holtz, W | 1 |
| Unglaub-Leisten, I | 1 |
| Stickl, H | 1 |
| Frick, E | 1 |
| Angstwurm, H | 1 |
| Ring, J | 1 |
| Vormittag, W | 2 |
| Diadyk, AI | 1 |
| Sokhin, AA | 1 |
| Siniachenko, OV | 1 |
| Efremenko, VA | 1 |
| Bagriĭ, AE | 1 |
| Nikolenko, IuI | 1 |
| Iarovaia, NF | 1 |
| Nikolenko, VIu | 1 |
| Fukuda, M | 1 |
| Aikawa, I | 1 |
| Ohmori, Y | 1 |
| Yoshimura, N | 1 |
| Nakai, I | 1 |
| Matui, S | 1 |
| Oka, T | 1 |
| Pikler, GM | 1 |
| Say, B | 1 |
| Stamper, S | 1 |
| Ihle, BU | 1 |
| Constable, J | 1 |
| Gordon, S | 1 |
| Mahony, JF | 1 |
| Ganner, E | 1 |
| Osment, J | 1 |
| Dittrich, P | 1 |
| Huber, H | 1 |
| van Zyl, J | 1 |
| Wissmüller, HF | 1 |
| Friedrich, U | 2 |
| Zeuthen, E | 2 |
| Gevers, RH | 1 |
| Hintzen, AH | 1 |
| Kalff, MW | 1 |
| Ruys, JH | 1 |
| Dooren, LJ | 1 |
| Leb, DE | 1 |
| Weisskopf, B | 1 |
| Kanovitz, BS | 1 |
| Szántó, L | 1 |
| Czeizel, E | 1 |
| Hampel, KE | 1 |
| Lackner, A | 1 |
| Schulz, G | 1 |
| Busse, V | 1 |
| Gilgenkrantz, S | 1 |
| Weber, M | 1 |
| Grandidier, M | 1 |
| Beurey, J | 1 |
| Eberle, P | 1 |
| Hunstein, W | 1 |
| Soborg, M | 1 |
2 reviews available for azathioprine and Abnormalities, Autosome
| Article | Year |
|---|---|
A case of therapy-related myeloid neoplasm in a patient with Crohn's disease treated with azathioprine.
Topics: Aged; Antineoplastic Agents; Azathioprine; Bone Marrow; Chromosome Aberrations; Crohn Disease; Human | 2012 |
International Commission for Protection Against Environmental Mutagens and Carcinogens. Cyclosporine A: review of genotoxicity and potential for adverse human reproductive and developmental effects. Report of a Working Group on the genotoxicity of cyclosp
Topics: Animals; Azathioprine; Chromosome Aberrations; Cyclosporine; Fetus; Humans; Neoplasms; Prednisone; R | 1994 |
37 other studies available for azathioprine and Abnormalities, Autosome
| Article | Year |
|---|---|
Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; | 2003 |
A case of refractory anemia with 17p- syndrome following azathioprine treatment for heart transplantation.
Topics: Anemia, Refractory; Azathioprine; Chromosome Aberrations; Chromosomes, Human, Pair 17; Heart Transpl | 2004 |
[Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations].
Topics: Anemia; Azathioprine; Bone Marrow; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Hum | 2004 |
Chromosome studies in patients treated with azathioprine and amethopterin.
Topics: Adult; Autoimmune Diseases; Azathioprine; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Ch | 1967 |
Azathioprine, a clastogen in human somatic cells? Analysis of chromosome damage and SCE in lymphocytes after exposure in vivo and in vitro.
Topics: Adult; Azathioprine; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Crossing Over, Gen | 1981 |
Long-term effects of azathioprine in rheumatoid arthritis.
Topics: Adenocarcinoma; alpha-Fetoproteins; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Dos | 1982 |
Two chromosome aberrations in the child of a woman with systemic lupus erythematosus treated with azathioprine and prednisone.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Azathioprine; Chromosome Aberrations; C | 1984 |
The comparative incidence of malignant disease in rheumatoid arthritics exposed to different treatment regimens.
Topics: Adult; Aged; Animals; Arthritis, Rheumatoid; Azathioprine; Carcinoma, Transitional Cell; Chromosome | 1982 |
Chromosomal aberrations and sister-chromatid exchanges (SCEs) in patients undergoing long-term Imuran therapy.
Topics: Azathioprine; Blood Cells; Chromosome Aberrations; Humans; Kidney Transplantation; Kinetics; Prednis | 1982 |
Genotoxicity evaluation of cyclosporin A, a new immunosuppressive agent.
Topics: Animals; Azathioprine; Bone Marrow; Cell Nucleus; Chromosome Aberrations; Cricetinae; Cyclosporins; | 1982 |
[Azathioprine in rheumatology].
Topics: Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Humans; Immunosuppression Therapy; Lupu | 1979 |
Erythroleukemia in a renal transplant recipient.
Topics: Azathioprine; Chromosome Aberrations; Humans; Kidney Transplantation; Leukemia, Erythroblastic, Acut | 1979 |
[Visual and electronic analysis of chromosomes in the Göttingen miniature pig following adminstration of azathioprine].
Topics: Animals; Azathioprine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Female; Karyotypin | 1977 |
Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and delta 9-THC, using the micronucleus test.
Topics: Animals; Azathioprine; Bone Marrow; Chromosome Aberrations; Dronabinol; Lysergic Acid Diethylamide; | 1978 |
Immunosuppressive drugs and the foetus.
Topics: Azathioprine; Chromosome Aberrations; Female; Fetus; Humans; Hydrocortisone; Kidney Transplantation; | 1976 |
Assessment of the effect of azathioprine on human bone marrow cells in vivo, combining chromosome studies and the micronucleus test.
Topics: Adult; Aged; Azathioprine; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Chromosome Aberrations; Ery | 1976 |
Effects of inhibitors of DNA, RNA and protein synthesis on frequencies and types of premature chromosome condensation from X-ray induced micronuclei.
Topics: Azathioprine; Cell Nucleus; Chromosome Aberrations; Cytarabine; Dactinomycin; DNA; Ethidium; Humans; | 1976 |
[The effect of azathioprine on the occurrence of chromosome abnormalities in the Göttingen miniature swine].
Topics: Animals; Azathioprine; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Female; Male; Swin | 1975 |
[Chromosomal aberrations in peripheral lymphocytes of patients with multiple sclerosis (author's transl)].
Topics: Adult; Antilymphocyte Serum; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 4-5; Chromoso | 1975 |
[Induction of chromosome aberrations by antirheumatic therapy].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Cyclophosphamide; Gold; Hu | 1975 |
[Chromosome aberration levels and their dynamics during the treatment with cytotoxic preparations of patients with primary and lupus glomerulonephritis].
Topics: Adolescent; Adult; Azathioprine; Cells, Cultured; Chromosome Aberrations; Cyclophosphamide; Female; | 1991 |
Chromosome aberrations in kidney transplant recipients.
Topics: Azathioprine; Chromosome Aberrations; Cyclosporins; Female; Humans; Immunosuppressive Agents; Kidney | 1987 |
Cytogenetic findings in acute monocytic leukemia in a renal allograft recipient.
Topics: Azathioprine; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Female; Humans; Immune Toleran | 1986 |
Myelodysplasia in cadaver renal allografts: a report of four cases.
Topics: Adult; Azathioprine; Bone Marrow; Chromosome Aberrations; Chromosomes, Human, 16-18; Chromosomes, Hu | 1985 |
[Cytostatic immunosuppressive therapy, chromosomal aberrations and carcinogenic effect (author's transl)].
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Chromosome Aberrations; Chromosomes, Human, 1-3; C | 1974 |
Chromosomes in patients treated with azathioprine.
Topics: Adult; Azathioprine; Bone Marrow Cells; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromos | 1973 |
The clastogenic effect of azathioprine on human chromosomes in vitro.
Topics: Adult; Azathioprine; Chromatids; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Dr | 1974 |
[Chromosome abnormalities and treatment with Imuran (azathioprine) following kidney transplantation].
Topics: Adolescent; Adult; Azathioprine; Child; Chromosome Aberrations; Chromosome Disorders; Female; Glomer | 1970 |
[Two cases of pregnancy following kidney transplantation].
Topics: Adult; Azathioprine; Chromosome Aberrations; Chromosome Disorders; Female; Graft Rejection; Humans; | 1971 |
[Chromosome examination in children of parents treated with Imuran].
Topics: Abnormalities, Drug-Induced; Adult; Azathioprine; Chromosome Aberrations; Chromosomes; Female; Human | 1971 |
Chromosome aberrations in the child of a kidney transplant recipient.
Topics: Abnormalities, Drug-Induced; Adult; Azathioprine; Cadaver; Chromosome Aberrations; Female; Fetus; Hu | 1971 |
[Chromosome aberrations related to Imuran therapy].
Topics: Azathioprine; Chromosome Aberrations; Chromosome Disorders; Humans | 1972 |
[Chromosome mutation caused by azathioprine in human leukocytes in vitro].
Topics: Azathioprine; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Humans; In Vitro Techni | 1971 |
Effect of azathioprine on the chromosome complement of human bone marrow cells.
Topics: Adult; Aged; Azathioprine; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Fema | 1970 |
[Immunosuppressive agents and cytogenetics].
Topics: Azathioprine; Chromosome Aberrations; Cytogenetics; Female; Humans; Immunosuppressive Agents; Leukem | 1970 |
Chromosomes in patients treated with Imuran.
Topics: Azathioprine; Chromosome Aberrations; Female; Glomerulonephritis; Hepatitis; Humans; Lupus Erythemat | 1968 |
[A warning: chromosome anomalies after use of azathioprine (imuran)].
Topics: Azathioprine; Chromosome Aberrations; Chromosome Disorders; Humans | 1965 |