Page last updated: 2024-10-23

azathioprine and 2019 Novel Coronavirus Disease

azathioprine has been researched along with 2019 Novel Coronavirus Disease in 27 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"A 77-year-old patient with ulcerative colitis (UC) was transferred to our department because of worsening bloody diarrhea and abdominal pain, which was consistent with a UC flare."5.91An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine. ( Hirayama, D; Ishigami, K; Kazama, T; Nakase, H; Ohwada, S; Yamakawa, T; Yamano, HO; Yoshii, S, 2023)
"A VKH disease patient, well controlled on azathioprine therapy, presented a uveitis relapse eleven days after the first vaccination for COVID-19."4.12Vogt-Koyanagi-Harada Relapse after COVID-19 Vaccination. ( Accorinti, M; Manni, P; Saturno, MC, 2022)
" A 40-year-old man with a history of rheumatoid arthritis treated with prednisolone, Disease-Modifying Anti-Rheumatic Drugs (DMARDs), and biologic agents was admitted with chief complaints of fever, chills, malaise, myalgia, and dyspnea."3.96COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with? ( Ahmadinejad, Z; Assari, R; Ayoobi Yazdi, N; Javanshayani, P; Khalili Afousi, H; Mazloomi, SH; Ziaee, V, 2020)
"Only few cases of vaccine-induced immune thrombocytopenia or immune hemolysis have been reported so far."3.01Relapse of Evans syndrome following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine: case report and literature review. ( Cvetković, M; Mitrović, M; Pantić, N; Pravdić, Z; Sabljić, N; Suvajdžić-Vuković, N; Virijević, M, 2023)
" However, the effects of glucocorticoids, methotrexate, TNF inhibitors and JAK inhibitors on vaccine responses remain unclear and could depend on the dosage and type of vaccination."3.01Effect of DMARDs on the immunogenicity of vaccines. ( Brouwer, E; Huckriede, ALW; van Baarle, D; van der Geest, KSM; van Sleen, Y, 2023)
"Achondroplasia is the commonest skeletal dysplasia of autosomal dominant inheritance caused by "gain of function" mutations in the fibroblast growth factor receptor 3 (FGFR3) gene."2.82Myasthenia gravis complicating the surgical management of achondroplasia: a case-based update. ( Afshari, FT; Debenham, P; Parida, A; Solanki, GA, 2022)
"A 77-year-old patient with ulcerative colitis (UC) was transferred to our department because of worsening bloody diarrhea and abdominal pain, which was consistent with a UC flare."1.91An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine. ( Hirayama, D; Ishigami, K; Kazama, T; Nakase, H; Ohwada, S; Yamakawa, T; Yamano, HO; Yoshii, S, 2023)
"Ulcerative colitis was diagnosed 6 months earlier and treated with mesalamine 80 mg/kg/day and azathioprine 2."1.72SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis: A case report. ( Abbas, A; Alhalabi, M; Ali, F; Eddin, KA, 2022)
"The chronic use of immunosuppressive drugs is a key risk factor of death because of coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTRs), although no evident association between the class of immunosuppressive and outcomes has been observed."1.72The Mycophenolate-based Immunosuppressive Regimen Is Associated With Increased Mortality in Kidney Transplant Patients With COVID-19. ( Almeida, RAMB; Calazans, CAC; Charpiot, IMMF; Costa, KMAH; Cristelli, MP; de Lima, PR; de Sandes-Freitas, TV; Deboni, LM; Ferreira, GF; Ferreira, TCA; Garcia, VD; Manfro, RC; Mazzali, M; Medina-Pestana, J; Modelli de Andrade, LG; Nakamura, MR; Oriá, RB; Pacheco-Silva, A; Requião-Moura, LR; Simão, DR; Tedesco-Silva, H; Viana, LA, 2022)
" Additional goal was to evaluate adverse events of vaccination."1.72Efficacy and safety of SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive and biological therapy: Prospective observational study. ( Coufal, S; Cupkova, A; Drabek, J; Hlava, S; Keil, R; Koptová, P; Kucerova, B; Milota, T; Pichlerová, D; Stovicek, J; Trojanek, M; Wasserbauer, M, 2022)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's27 (100.00)2.80

Authors

AuthorsStudies
Kabaçam, G1
Wahlin, S1
Efe, C1
Classen, JM1
Muzalyova, A1
Nagl, S1
Fleischmann, C1
Ebigbo, A1
Römmele, C1
Messmann, H1
Schnoy, E1
Alhalabi, M1
Eddin, KA1
Ali, F1
Abbas, A1
Accorinti, M1
Saturno, MC1
Manni, P1
Li, J1
Ayada, I1
Wang, Y1
den Hoed, CM1
Kamar, N1
Peppelenbosch, MP1
de Vries, AC1
Li, P1
Pan, Q1
Paybast, S1
Emami, A1
Baghalha, F1
Naser Moghadasi, A1
Requião-Moura, LR1
Modelli de Andrade, LG1
de Sandes-Freitas, TV1
Cristelli, MP1
Viana, LA1
Nakamura, MR1
Garcia, VD1
Manfro, RC1
Simão, DR1
Almeida, RAMB1
Ferreira, GF1
Costa, KMAH1
de Lima, PR1
Pacheco-Silva, A1
Charpiot, IMMF1
Deboni, LM1
Ferreira, TCA1
Mazzali, M1
Calazans, CAC1
Oriá, RB1
Tedesco-Silva, H1
Medina-Pestana, J1
den Otter, AAS1
van der Houwen, TB1
van Hagen, PM1
van Laar, JAM1
El Hasbani, G1
Uthman, I1
Afshari, FT1
Parida, A1
Debenham, P1
Solanki, GA1
Wasserbauer, M1
Hlava, S1
Trojanek, M1
Stovicek, J1
Milota, T1
Drabek, J1
Koptová, P1
Cupkova, A1
Pichlerová, D1
Kucerova, B1
Coufal, S1
Keil, R1
Choi, SY1
Choi, S1
Kang, B1
Choe, BH1
Lee, YJ1
Park, JH1
Kim, YB1
Kim, JY1
Lee, K1
Lee, KJ1
Kang, KS1
Lee, YM1
Kim, HJ1
Kang, Y1
Jang, HJ1
Yi, DY1
Hong, SJ1
Choi, YJ1
Hong, J1
Kim, SC1
Yamakawa, T3
Ishigami, K3
Ohwada, S3
Kazama, T3
Hirayama, D3
Yoshii, S3
Yamano, HO3
Nakase, H3
Barrett, R2
Lin, SX1
Culliford, D1
Fraser, S1
Edwards, CJ1
Kridin, K1
Mruwat, N1
Amber, KT1
Ludwig, RJ1
Kim, S1
Lee, EK1
Sohn, E1
Ueno, M1
Takabatake, H1
Itakura, J1
Fujita, R1
Kayahara, T1
Morimoto, Y1
Notohara, K1
Mizuno, M1
Cvetković, M1
Pantić, N1
Virijević, M1
Pravdić, Z1
Sabljić, N1
Mitrović, M1
Suvajdžić-Vuković, N1
van Sleen, Y1
van der Geest, KSM1
Huckriede, ALW1
van Baarle, D1
Brouwer, E1
Bozzalla Cassione, E1
Zanframundo, G1
Biglia, A1
Codullo, V1
Montecucco, C1
Cavagna, L1
Khan, N1
Patel, D1
Xie, D1
Lewis, J1
Trivedi, C1
Yang, YX1
Corrêa, DG1
de Souza Lima, FC1
da Cruz Bezerra, D1
Coutinho, AC1
Hygino da Cruz, LC1
Ungaro, RC1
Brenner, EJ1
Gearry, RB1
Kaplan, GG1
Kissous-Hunt, M1
Lewis, JD1
Ng, SC1
Rahier, JF1
Reinisch, W1
Steinwurz, F1
Underwood, FE1
Zhang, X1
Colombel, JF1
Kappelman, MD1
Ahmadinejad, Z1
Assari, R1
Ayoobi Yazdi, N1
Mazloomi, SH1
Javanshayani, P1
Khalili Afousi, H1
Ziaee, V1
Lees, CW1
Irving, PM1
Beaugerie, L1
Reder, AT1
Centonze, D1
Naylor, ML1
Nagpal, A1
Rajbhandari, R1
Altincatal, A1
Kim, M1
Berdofe, A1
Radhakrishnan, M1
Jung, E1
Sandrock, AW1
Smirnakis, K1
Popescu, C1
de Moor, C1
Vuille-Lessard, É1
Montani, M1
Bosch, J1
Semmo, N1

Reviews

6 reviews available for azathioprine and 2019 Novel Coronavirus Disease

ArticleYear
Factors Associated With COVID-19 Vaccine Response in Transplant Recipients: A Systematic Review and Meta-analysis.
    Transplantation, 2022, 10-01, Volume: 106, Issue:10

    Topics: Antibodies, Viral; Azathioprine; Calcineurin Inhibitors; COVID-19; COVID-19 Vaccines; Humans; Immuno

2022
Watch out for neuromyelitis optica spectrum disorder onset or clinical relapse after COVID-19 vaccination: What neurologists need to know?
    Multiple sclerosis and related disorders, 2022, Volume: 65

    Topics: Aquaporin 4; Azathioprine; COVID-19; COVID-19 Vaccines; Female; Humans; Male; Middle Aged; Neoplasm

2022
Myasthenia gravis complicating the surgical management of achondroplasia: a case-based update.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2022, Volume: 38, Issue:10

    Topics: Achondroplasia; Anesthetics; Azathioprine; Child; Constriction, Pathologic; COVID-19; Female; Humans

2022
Corticosteroid-refractory autoimmune hepatitis after COVID-19 vaccination: a case report and literature review.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:4

    Topics: Adrenal Cortex Hormones; Azathioprine; COVID-19; COVID-19 Vaccines; Female; Hepatitis, Autoimmune; H

2023
Relapse of Evans syndrome following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine: case report and literature review.
    Journal of infection in developing countries, 2023, 06-30, Volume: 17, Issue:6

    Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Bilirubin; BNT162 Vaccine; Chronic Disease; COVID-19; C

2023
Effect of DMARDs on the immunogenicity of vaccines.
    Nature reviews. Rheumatology, 2023, Volume: 19, Issue:9

    Topics: Antirheumatic Agents; Azathioprine; COVID-19; Humans; SARS-CoV-2; Vaccination; Vaccines

2023

Other Studies

21 other studies available for azathioprine and 2019 Novel Coronavirus Disease

ArticleYear
Autoimmune hepatitis triggered by COVID-19: A report of two cases.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:10

    Topics: Azathioprine; COVID-19; Hepatitis, Autoimmune; Humans; SARS-CoV-2

2021
Antibody Response to SARS-CoV-2 Vaccination in Patients with Inflammatory Bowel Disease: Results of a Single-Center Cohort Study in a Tertiary Hospital in Germany.
    Digestive diseases (Basel, Switzerland), 2022, Volume: 40, Issue:6

    Topics: Aged; Antibody Formation; Azathioprine; Cohort Studies; COVID-19; COVID-19 Vaccines; Crohn Disease;

2022
SARS-CoV-2 (COVID-19) pneumonia patient treated with two doses of infliximab within 2 weeks for acute severe ulcerative colitis: A case report.
    Medicine, 2022, Jan-28, Volume: 101, Issue:4

    Topics: Adult; Azathioprine; Colitis, Ulcerative; COVID-19; COVID-19 Drug Treatment; Humans; Infliximab; Mal

2022
Vogt-Koyanagi-Harada Relapse after COVID-19 Vaccination.
    Ocular immunology and inflammation, 2022, Volume: 30, Issue:5

    Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; COVID-19; COVID-19 Vaccines; Female; Humans;

2022
The Mycophenolate-based Immunosuppressive Regimen Is Associated With Increased Mortality in Kidney Transplant Patients With COVID-19.
    Transplantation, 2022, 10-01, Volume: 106, Issue:10

    Topics: Azathioprine; Calcineurin Inhibitors; COVID-19; Enzyme Inhibitors; Humans; Immunosuppressive Agents;

2022
Clinical course of COVID-19 infections in patients with Behçet's disease in The Netherlands.
    Clinical and experimental rheumatology, 2022, Volume: 40, Issue:8

    Topics: Adult; Azathioprine; Behcet Syndrome; COVID-19; Female; Humans; Male; Netherlands; Retrospective Stu

2022
ANCA-Associated Vasculitis following the First Dose of Pfizer-BioNTech COVID-19 Vaccine.
    Nephron, 2023, Volume: 147, Issue:2

    Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathioprine; BNT162 Vaccine; COVID-19;

2023
Efficacy and safety of SARS-CoV-2 vaccination in patients with inflammatory bowel disease on immunosuppressive and biological therapy: Prospective observational study.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Antibodies, Viral; Azathioprine; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; Humans; Inflammatory B

2022
Epidemiological Trends of Pediatric Inflammatory Bowel Disease in Korea: A Multicenter Study of the Last 3 Years Including the COVID-19 Era.
    Journal of Korean medical science, 2022, Sep-26, Volume: 37, Issue:37

    Topics: Azathioprine; Colitis, Ulcerative; COVID-19; Crohn Disease; Humans; Inflammatory Bowel Diseases; Inf

2022
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
An older patient with active ulcerative colitis and coronavirus disease 2019 (COVID-19) pneumonia successfully treated with the combination of anti-TNFα therapy and azathioprine.
    Clinical journal of gastroenterology, 2023, Volume: 16, Issue:2

    Topics: Aged; Azathioprine; Colitis, Ulcerative; COVID-19; Female; Humans; Infliximab; Pneumonia; SARS-CoV-2

2023
Impact of the COVID-19 pandemic on prescription refills for immune-mediated inflammatory disorders: a time series analysis (January 2019 to January 2021) using the English Prescribing Dataset.
    BMJ open, 2022, 12-23, Volume: 12, Issue:12

    Topics: Azathioprine; Communicable Disease Control; COVID-19; Drug Prescriptions; Humans; Hydroxychloroquine

2022
Risk of infections in patients with pemphigus treated with rituximab vs. azathioprine or mycophenolate mofetil: a large-scale global cohort study.
    The British journal of dermatology, 2023, 03-30, Volume: 188, Issue:4

    Topics: Azathioprine; Cohort Studies; COVID-19; Cytomegalovirus Infections; Humans; Immunosuppressive Agents

2023
Two Case Reports of Chronic Inflammatory Demyelinating Polyneuropathy After COVID-19 Vaccination.
    Journal of Korean medical science, 2023, Feb-27, Volume: 38, Issue:8

    Topics: 2019-nCoV Vaccine mRNA-1273; Ad26COVS1; Aged; Azathioprine; COVID-19; COVID-19 Vaccines; Guillain-Ba

2023
COVID-19 infection in a northern-Italian cohort of systemic lupus erythematosus assessed by telemedicine.
    Annals of the rheumatic diseases, 2020, Volume: 79, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Azathioprine; Betacoronavirus; Clinical Labora

2020
Impact of Anti-Tumor Necrosis Factor and Thiopurine Medications on the Development of COVID-19 in Patients With Inflammatory Bowel Disease: A Nationwide Veterans Administration Cohort Study.
    Gastroenterology, 2020, Volume: 159, Issue:4

    Topics: Adult; Aged; Azathioprine; Betacoronavirus; Coronavirus Infections; COVID-19; Gastrointestinal Agent

2020
COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: Cause or coincidence?
    Multiple sclerosis (Houndmills, Basingstoke, England), 2021, Volume: 27, Issue:6

    Topics: Aquaporin 4; Autoantibodies; Autoimmune Diseases; Azathioprine; Brain; COVID-19; Encephalomyelitis;

2021
Effect of IBD medications on COVID-19 outcomes: results from an international registry.
    Gut, 2021, Volume: 70, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; COVID-19; Drug Therapy, Combination; Female; Humans;

2021
COVID-19 pandemic and biological therapy in rheumatologic disorders: how to deal with?
    Reumatismo, 2020, Nov-19, Volume: 72, Issue:3

    Topics: Adalimumab; Adult; Antirheumatic Agents; Antiviral Agents; Arthritis, Rheumatoid; Azathioprine; Beta

2020
COVID-19 and IBD drugs: should we change anything at the moment?
    Gut, 2021, Volume: 70, Issue:4

    Topics: Azathioprine; COVID-19; Humans; Inflammatory Bowel Diseases; Infliximab; Pharmaceutical Preparations

2021
COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
    CNS drugs, 2021, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alemtuzumab; Azathioprine; Black or African American; Cl

2021
Autoimmune hepatitis triggered by SARS-CoV-2 vaccination.
    Journal of autoimmunity, 2021, Volume: 123

    Topics: 2019-nCoV Vaccine mRNA-1273; Aged; Autoantibodies; Azathioprine; Carcinoma, Transitional Cell; Causa

2021