azaspiracid and Leukemia--T-Cell

azaspiracid has been researched along with Leukemia--T-Cell* in 1 studies

Other Studies

1 other study(ies) available for azaspiracid and Leukemia--T-Cell

Article	Year
Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum. Marine drugs, 2015, Oct-30, Volume: 13, Issue:11 Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structures were determined to be 3-hydroxy-8-methyl-39-demethyl-azaspiracid-1 (1) and 3-hydroxy-7,8-dihydro-39-demethyl-azaspiracid-1 (2) by ¹H- and (13)C-NMR. Using the Jurkat T lymphocyte cell toxicity assay, (1) and (2) were found to be 6- and 3-fold less toxic than AZA-1, respectively. Topics: Dinoflagellida; Humans; Jurkat Cells; Leukemia, T-Cell; Magnetic Resonance Spectroscopy; Marine Toxins; Republic of Korea; Species Specificity; Spiro Compounds; Toxicity Tests	2015

Article

Year

Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum.

Marine drugs, 2015, Oct-30, Volume: 13, Issue:11

Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structures were determined to be 3-hydroxy-8-methyl-39-demethyl-azaspiracid-1 (1) and 3-hydroxy-7,8-dihydro-39-demethyl-azaspiracid-1 (2) by ¹H- and (13)C-NMR. Using the Jurkat T lymphocyte cell toxicity assay, (1) and (2) were found to be 6- and 3-fold less toxic than AZA-1, respectively.

Topics: Dinoflagellida; Humans; Jurkat Cells; Leukemia, T-Cell; Magnetic Resonance Spectroscopy; Marine Toxins; Republic of Korea; Species Specificity; Spiro Compounds; Toxicity Tests

2015