azaguanine has been researched along with Neoplasms* in 42 studies
3 review(s) available for azaguanine and Neoplasms
| Article | Year |
|---|---|
Rationale of combination chemotherapy based on preclinical experiments.
Topics: Animals; Antineoplastic Agents; Azaguanine; Carcinoma; Cytarabine; Drug Synergism; Humans; Hydroxyurea; Immunotherapy; Leukemia L1210; Lung Neoplasms; Melanoma; Neoplasms; Thiosemicarbazones; Time Factors | 1973 |
[CHEMOTHERAPY OF UTERINE CERVIX CARCINOMA].
Topics: Antineoplastic Agents; Azaguanine; Aziridines; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Female; Fluorouracil; Humans; Infusions, Parenteral; Melphalan; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Triaziquone; Uracil Mustard; Uterine Cervical Neoplasms; Vinblastine | 1964 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
39 other study(ies) available for azaguanine and Neoplasms
| Article | Year |
|---|---|
Induction of 8-azaguanine-resistant mutation and neoplastic transformation of hamster embryonic cells by coadministration of sodium nitrite and aminopyrine.
Hamster embryos in utero on the 11th or 12th day of gestation were treated simultaneously with aminopyrine (Ap) and sodium nitrite (NaNO2) by oral administration of the compounds to the mothers by stomach tube. For measurement of induction of 8 AG-resistant mutations, the embryonic cells from treated and control mothers were cultured in MEM plus 10% FBS for 72 h and then selected in medium containing 10 or 20 microgram/ml of 8 AG. The number of 8 AG-resistant colonies was markedly increased after co-administration of Ap and NaNO2, and slight induction of mutations was also observed in cells from mothers given NaNO2 alone. This treatment also caused morphological or malignant transformation of cultured cells. About 5- to 6-fold increase in the number of transformed colonies was observed in cells from mothers given Ap plus NaNO2. Cells from the transformed colonies produced tumors when implanted into the cheek pouches of young golden hamsters. These tumors were diagnosed as pleomorphic fibrosarcomas. Similar results were obtained with cells from embryos treated transplacentally with NDMA as positive controls. A single transplacental oral application of Ap at 200 mg/kg or of NaNO2 had only slight biological actions to the cultured embryonic cells. NDMA was produced in the stomach of animals treated simultaneously with Ap and NaNO2. A small amount of NDMA was also detected in the stomach after a single dose of NaNO2. Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Azaguanine; Cells, Cultured; Cricetinae; Dimethylnitrosamine; Female; In Vitro Techniques; Maternal-Fetal Exchange; Mutation; Neoplasms; Nitrites; Pregnancy; Sodium Nitrite | 1980 |
Studies on the isolation and properties of drug resistant mutants from a human malignant cell line.
Topics: Aminopterin; Azaguanine; Cell Line; Culture Techniques; Humans; Mutation; Neoplasms | 1968 |
[DRUG THERAPY OF UTERINE CANCER].
Topics: Antineoplastic Agents; Azaguanine; Blood Chemical Analysis; Catalase; Clinical Enzyme Tests; Deoxyribonucleases; DNA; Female; Fructose-Bisphosphate Aldolase; Humans; L-Lactate Dehydrogenase; Metabolism; Mitomycin; Mitomycins; Neoplasms; Physiology; Ribonucleases; Uterine Cervical Neoplasms; Uterine Neoplasms | 1964 |
INFLUENCES OF ANTICANCER AGENTS ON THE METABOLISM OF DELTA-AMINOLEVULINIC ACID IN MORMAL AND TUMOR-BEARING MICE.
Topics: Alkylating Agents; Amino Acids; Aminolevulinic Acid; Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Blood Chemical Analysis; Carcinoma, Ehrlich Tumor; Catalase; Copper; Folic Acid Antagonists; Hemoglobins; Hydro-Lyases; Iron; Levulinic Acids; Liver; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Rats; Research | 1964 |
INCORPORATION OF 8-AZAGUANINE AND GROWTH INHIBITION IN MAMMALIAN SPINNER CULTURES.
Topics: Azaguanine; Carbon Isotopes; Cell Biology; DNA; DNA, Neoplasm; Guanine; Lysine; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Research; RNA; RNA, Neoplasm; Tissue Culture Techniques; Urethane | 1964 |
THE ADVERSE EFFECTS OF CANCER CHEMOTHERAPY.
Topics: Animals; Antineoplastic Agents; Azaguanine; Carcinoma, Ehrlich Tumor; Cortisone; Cyclophosphamide; Dactinomycin; Mechlorethamine; Mice; Mitomycin; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma; Sarcoma, Yoshida; Thiotepa; Toxicology | 1964 |
IN VITRO CULTURE OF YOSHIDA SARCOMA CELLS: METHODS FOR DETERMINING ACQUIRED RESISTANCE TO DRUGS.
Topics: Animals; Antineoplastic Agents; Azaguanine; Culture Media; Cyclophosphamide; Dactinomycin; Drug Tolerance; Fluorouracil; Glucosamine; Histocytochemistry; In Vitro Techniques; Mechlorethamine; Mercaptopurine; Mitomycin; Mitomycins; Neoplasm Transplantation; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Rats; Research; Sarcoma; Sarcoma, Experimental; Sarcoma, Yoshida; Thiotepa; Tissue Culture Techniques | 1964 |
Influences of anticancer agents on the activities of liver catalase, uricase, and xanthine oxidase in normal and tumor-bearing mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Carboxylic Acids; Carcinoma, Ehrlich Tumor; Catalase; Cyclopentanes; Liver; Mercaptopurine; Methotrexate; Mice; N-Glycosyl Hydrolases; Neoplasms; Oxidoreductases; Thiotepa; Urate Oxidase; Xanthine Oxidase | 1963 |
THE EFFECT OF CHEMOTHERAPEUTIC AGENTS UPON THE METABOLISM OF INTACT HUMAN CANCER CELLS: AN IN VITRO TECHNIC FOR CELL SENSITIVITY.
Topics: Aminopterin; Antineoplastic Agents; Azaguanine; Carbohydrate Metabolism; In Vitro Techniques; Lactates; Leukemia; Leukocytes; Mechlorethamine; Mercaptopurine; Metabolism; Neoplasms; Prednisone; Research; Thiotepa; Vinblastine | 1963 |
THERAPEUTIC EFFECT OF ANTICANCER DRUGS ON SKIN CANCER.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Headache; Japan; Leukopenia; Middle Aged; Mitomycin; Neoplasms; Nitrogen Mustard Compounds; Prognosis; Skin Neoplasms; Toxicology; Uracil Mustard | 1963 |
DNA transformation studies with mammalian cells in culture.
Topics: Animals; Azaguanine; DNA; DNA, Neoplasm; Humans; Leukemia; Leukemia, Lymphoid; Lymphocytes; Neoplasms | 1962 |
[Action of 6-mercaptopurine and of 8-azaguanine on Galliera sarcoma in the rat].
Topics: Animals; Azaguanine; Mercaptopurine; Neoplasms; Rats; Sarcoma | 1960 |
[Findings on 8-azaguanine used in man in cancer therapy].
Topics: Antineoplastic Agents; Azaguanine; Guanine; Neoplasms | 1957 |
[Studies upon the chemotherapy of experimental malignant tumors with a new preparation of cobaltous bis-histidine chelate compound carrying 8-azaguanine].
Topics: Animals; Antineoplastic Agents; Azaguanine; Guanine; Histidine; Neoplasms; Neoplasms, Experimental | 1957 |
[Clinical experience of some anti-tumor substances. 2. Therapeutic effect of sarkomycin, actinomycin J and 8-azaguanine on malignant growth].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Azaguanine; Dactinomycin; Dermatologic Agents; Guanine; Neoplasms | 1956 |
Combination chemotherapy of mouse tumors with 8-azaguanine and flavotin.
Topics: Animals; Azaguanine; Breast Neoplasms; Drug Therapy, Combination; Guanine; Humans; Leukemia, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Riboflavin | 1955 |
[Effects of 8-azaguanine on malignant tumors. III. Its effects on the Yoshida sarcoma; estimation of DNA content].
Topics: Animals; Azaguanine; DNA; Guanine; Neoplasms; Nucleic Acids; Ploidies; Sarcoma; Sarcoma, Yoshida | 1955 |
The influence of 8-azaguanine on tumors and enhancement.
Topics: Animals; Azaguanine; Guanine; Leadership; Neoplasms; Neoplasms, Experimental; Refractive Surgical Procedures | 1955 |
[Clinical studies on cancer chemotherapy. IV. 8-Azaguanine].
Topics: Animals; Azaguanine; Biomedical Research; Guanine; Neoplasms | 1955 |
The incorporation of 8-azaguanine into nucleic acids of tumor-bearing mice.
Topics: Animals; Azaguanine; Guanine; Liver; Mice; Neoplasms; Nucleic Acids; Sarcoma; Sarcoma, Experimental | 1954 |
[Effect of 8-azaguanine on malignant tumor].
Topics: Animals; Azaguanine; Guanine; Neoplasms; Neoplasms, Experimental | 1954 |
[Enzymatic deamination of 8-azaguanine by ascites tumors in rats].
Topics: Animals; Ascites; Azaguanine; Carcinoma, Ehrlich Tumor; Deamination; Guanine; Neoplasms; Rats | 1954 |
The effects of tumor growth, x-radiation, and 8-azaguanine on the incorporation of adenine into nucleic acids of mice.
Topics: Adenine; Animals; Azaguanine; Guanine; Mice; Neoplasms; Nucleic Acids; Sarcoma; X-Rays | 1954 |
The effect of azaguanine on the incorporation of guanine and of 4-amino-5-imidazolecarboxamide into tumor-bearing mice.
Topics: Aminoimidazole Carboxamide; Animals; Azaguanine; Guanine; Imidazoles; Mice; Neoplasms | 1953 |
Combination chemotherapy of cancer: potentiation of carcinostatic action of 8-azaguanine by a riboflavin analog.
Topics: Animals; Azaguanine; Drug Therapy, Combination; Guanine; Neoplasms; Neoplasms, Experimental; Organic Chemicals; Riboflavin | 1953 |
[8-Azaguanine in the therapy of gynecologic malignant tumors].
Topics: Azaguanine; Female; Genital Neoplasms, Female; Genitalia; Genitalia, Female; Guanine; Humans; Neoplasms | 1953 |
[Effect of purine antagonist (8-azaguanine) on malignant tumor].
Topics: Antimetabolites; Azaguanine; Guanine; Neoplasms | 1953 |
Observations on the effects of administration of guanazolo in patients with disseminated neoplasms.
Topics: Azaguanine; Guanine; Neoplasms | 1952 |
Combination chemotherapy of cancer: potentiation of carcinostatic activity of 8-azaguanine by 6-formylpteridine.
Topics: Animals; Antimetabolites; Azaguanine; Drug Therapy, Combination; Folic Acid; Guanine; Neoplasms; Neoplasms, Experimental | 1952 |
Combination chemotherapy of cancer with 8-azaguanine and a riboflavin analog.
Topics: Animals; Azaguanine; Drug Therapy, Combination; Guanine; Inorganic Chemicals; Neoplasms; Neoplasms, Experimental; Riboflavin | 1952 |
A clinica study of the effect of guanazolo in neoplastic diseases.
Topics: Azaguanine; Guanine; Neoplasms | 1952 |
Enzymatic deamination of 8-azaguanine in normal and neoplastic tissues.
Topics: Amidohydrolases; Azaguanine; Deamination; Neoplasms | 1952 |
Further evidence on the mode of action of 8-azaguanine (guanazolo) in tumor inhibition.
Topics: Azaguanine; Guanine; Neoplasms | 1951 |
Metabolite antagonists in cancer; guanazolo.
Topics: Animals; Azaguanine; Humans; Neoplasms; Neoplasms, Experimental | 1951 |
The effect of azaguanine on mitosis in normal and neoplastic tissues.
Topics: Azaguanine; Guanine; Mitosis; Neoplasms | 1950 |
Studies on the distribution of radioactive 8-azaguanine (guanazolo) in mice with Eo 771 tumors.
Topics: Animals; Azaguanine; Guanine; Mice; Neoplasms | 1950 |
Studies on the mechanism of action of chemotherapeutic agents in cancer. IV. Relationship of guanine and guanylic acid to the action of guanazolo on lymphoid tumors in mice and rats.
Topics: Animals; Antineoplastic Agents; Azaguanine; Guanine; Guanosine Monophosphate; Lymphoma; Mice; Neoplasms; Rats | 1950 |
The effect of 5-amino-7-hydroxy-1H-v-triazolo (d) pyrimidine (guanazolo) on variety of neoplasms in experimental animals.
Topics: Animals; Azaguanine; Neoplasms; Pyrimidines | 1950 |
The effect of 8-azaguanine on the growth of carcinoma, sarcoma, osteogenic sarcoma, lymphosarcoma and melanoma in animals.
Topics: Animals; Azaguanine; Bone Neoplasms; Humans; Lymphoma, Non-Hodgkin; Melanoma; Neoplasms; Osteosarcoma; Sarcoma | 1950 |