azaguanine has been researched along with Lymphoma* in 11 studies
11 other study(ies) available for azaguanine and Lymphoma
Article | Year |
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Induction of mutation and chromosome damage by excess bases and nucleosides.
The studies reported in this communication were conducted to determine if naturally occurring cell constituents could themselves cause mutation. All the bases and their corresponding nucleosides have been shown in culture to produce chromosome damage in P388 mouse lymphoma and Chinese hamster ovary cells (CHO) and adenosine has produced an increased incidence of sister chromatid exchanges in CHO cells. In addition thymidine has produced an increase in V79 cells resistant to 8-azaguanine and ouabain, although no effects were seen in six strains of Salmonella typhimurium. Such damage probably arises as a result of imbalanced DNA-precursor pools. Thus mutagenic events may arise by mechanisms unrelated to direct alterations of DNA. Topics: Adenosine; Animals; Azaguanine; Cell Line; Cell Survival; Chromosomes; Cricetinae; Drug Resistance; Female; Lymphoma; Mice; Mutagenicity Tests; Mutation; Nucleosides; Ouabain; Ovary; Salmonella typhimurium; Sister Chromatid Exchange; Thymidine | 1985 |
The selection and induction of 5-iodo-2-deoxyuridine and thymidine variants of P388 mouse lymphoma cells with agents which are used for selection.
Topics: Animals; Azaguanine; Bromodeoxyuridine; Cell Line; Cell Survival; Genetic Variation; Idoxuridine; Lymphoma; Mice; Mutagens; Thymidine; Time Factors | 1975 |
Attempts to produce systems for isolating spontaneous and induced variants in various mouse lymphoma cells using a varity of selective agents.
Topics: Animals; Azaguanine; Cell Line; Cell Survival; Genetic Variation; Idoxuridine; Lymphoma; Methotrexate; Mice; Mutagens; Mutation; Selection, Genetic; Time Factors | 1975 |
The effect of post-treatment with caffeine on survival and UV-induced mutation frequencies in Chinese hamster and mouse lymphoma cells in vitro.
Topics: Animals; Azaguanine; Caffeine; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; DNA Repair; DNA Replication; Drug Resistance; Female; Lung; Lymphoma; Mice; Mutation; Ovary; Probability; Radiation Genetics; Sarcoma, Yoshida; Time Factors; Ultraviolet Rays | 1974 |
Immunoglobulin G and free kapa-chain synthesis in different clones of a hybrid cell line.
13 clonal cell lines were isolated from a hybrid cell population established by cell fusion between cloned BALB/c myeloma cells that were resistant to 8-azaguanine and produced immunoglobulin G and free kappa chain and C(67)BL/6n lymphoma cells that were resistant to bromodeoxyuridine and did not produce immunoglobulins. Some of the histocompatibility-2 antigens of both parental cell lines could be demonstrated on all of the hybrid clones. 11 clones synthesized only free kappa chain. Two clones synthesized IgG of BALB/c type, as well as free kappa chain. These clones had higher chromosome number than did the clones that synthesized only kappa chains. Topics: Animals; Antigens; Azaguanine; Bromodeoxyuridine; Cell Fusion; Cell Line; Clone Cells; Complement System Proteins; Culture Media; Histocompatibility; Hybrid Cells; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulins; Karyotyping; Lymphoma; Mice; Multiple Myeloma; Rabbits; Species Specificity | 1971 |
Mouse myelomas and lymphomas in culture.
Topics: Animals; Azaguanine; Cell Count; Cell Line; Chromosomes; Culture Techniques; Depression, Chemical; Hydrocortisone; Immunoglobulins; Leucine; Lymphoma; Mice; Neoplasm Transplantation; Plasmacytoma; Thymidine; Tritium | 1970 |
Purine pyrophosphorylase as a selective genetic marker in a mouse lymphoma, P388, in cell culture.
Topics: Animals; Azaguanine; Clone Cells; Culture Media; Culture Techniques; DNA, Neoplasm; Glycine; Hypoxanthines; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Purines; Thymidine | 1966 |
GROWTH INHIBITION OF A SPECTRUM OF TRANSPLANTED MOUSE TUMORS BY COMBINATIONS OF INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS AND ALKYLATING AGENTS.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; DNA; DNA, Neoplasm; Fluorouracil; Idoxuridine; Liver Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Mice; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nucleosides; Nucleotides; Purines; Research; RNA; RNA, Neoplasm; Sarcoma 180; Thioguanine; Uracil Mustard | 1963 |
[On the medical therapy of malignant lymphoma].
Topics: Antineoplastic Agents; Azaguanine; Cortisone; Cyclophosphamide; Humans; Lymphoma; Mercaptopurine; Mitomycin; Mitomycins; Nitrogen Mustard Compounds; Prednisolone; Thiotepa; Triethylenemelamine | 1962 |
Characterization of resistance to amethopterin, 8-azaguanine and several fluorinated pyrimidines in the murine lymphocytic neoplasm, P388.
Topics: Animals; Antineoplastic Agents; Azaguanine; Fluorouracil; Leukemia; Leukemia, Lymphoid; Lymphoma; Methotrexate; Mice; Nucleotides; Pyrimidines | 1962 |
Studies on the mechanism of action of chemotherapeutic agents in cancer. IV. Relationship of guanine and guanylic acid to the action of guanazolo on lymphoid tumors in mice and rats.
Topics: Animals; Antineoplastic Agents; Azaguanine; Guanine; Guanosine Monophosphate; Lymphoma; Mice; Neoplasms; Rats | 1950 |