azaguanine and Leukemia-P388

azaguanine has been researched along with Leukemia-P388* in 2 studies

Other Studies

2 other study(ies) available for azaguanine and Leukemia-P388

ArticleYear
Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:10

    The synthesis of 2-fluoro-8-azaadenosine (6e) and 2-amino-8-azaadenosine (6d) is described. Condensation of 9H-2,6-bis(methylthio)-8-azapurine (4) with 2,3,5-tri-O-acetyl-D-ribofuranosyl chloride (5) produces a mixture of 6a (9-beta-D-ribofuranosyl) and 7a (8-beta-D-ribofuranosyl). Standard functional group manipulation, including a modified Schiemann reaction to introduce the fluorine, allows preparation of 6d and 6e from the major isomer 6a. By a similar series of reactions the minor component 7a was converted to 7d and 7e, with the ribose ring attached at N-8 of the 8-azapurine ring system. Structure proofs utilized UV and 1H and 13C NMR data. Compounds 6b-e,g and 7b-f were evaluated in the H.Ep.-2 cell culture screen, and compounds 6c-e and 7d were evaluated in the P388 mouse leukemia screen. Adenosine deaminase data are also presented for some compounds.

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Drug Evaluation, Preclinical; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia P388; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1983
Purine nucleotide pyrophosphorylases in 8-azaguanine-sensitive and-resistant P388 leukemias.
    Journal of the National Cancer Institute, 1962, Volume: 29

    Topics: Animals; Azaguanine; Leukemia; Leukemia P388; Leukemia, Experimental; Nucleotidyltransferases; Purines; Pyrophosphatases; Transferases

1962