azaguanine and Breast-Neoplasms

By use of an assay system in vitro with cultured FM3A cells from a C3H mouse mammary carcinoma, tetracycline hydrochloride was found to have the ability to induce an 8-azaguanine-resistant mutation. It is suggested that an assay system using mammalian cells for the detection of mutagenicity of certain substances having antimicrobial action is more practical than a system using bacteria. As other effects of tetracycline hydrochloride on FM3A cells, the damage on chromosomes and the inhibition of syntheses of protein and nucleic acids were demonstrated.

Topics: Azaguanine; Breast Neoplasms; Carcinoma; Cell Line; Chromosome Aberrations; Mutagens; Mutation; Tetracycline

Topics: Animals; Azaguanine; Breast Neoplasms; Drug Therapy, Combination; Guanine; Humans; Leukemia, Experimental; Mice; Neoplasms; Neoplasms, Experimental; Riboflavin

Topics: Animals; Azaguanine; Breast; Breast Neoplasms; Diethylstilbestrol; Drug Therapy, Combination; Gonadal Steroid Hormones; Guanine; Humans; Mice; Neoplasms, Experimental