azadirachtin has been researched along with Amyloidosis* in 1 studies
1 other study(ies) available for azadirachtin and Amyloidosis
| Article | Year |
|---|---|
Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity.
The human islet amyloid polypeptide (hIAPP) or amylin is the major constituent of amyloidogenic aggregates found in pancreatic islets of type 2 diabetic patients that have been associated with β-cell dysfunction and/or death associated with type 2 diabetes mellitus (T2DM). Therefore, developing and/or identifying inhibitors of hIAPP aggregation pathway and/or compound that can mediate disaggregation of preformed aggregates holds promise as a medical intervention for T2DM management. In the current study, the anti-amyloidogenic potential of Azadirachtin (AZD)-a secondary metabolite isolated from traditional medicinal plant Neem ( Topics: Amyloid; Amyloidosis; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Limonins; Molecular Dynamics Simulation; Oxidative Stress | 2019 |