azacitidine has been researched along with Pancreatic Neoplasms in 63 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (3.17) | 18.2507 |
2000's | 28 (44.44) | 29.6817 |
2010's | 28 (44.44) | 24.3611 |
2020's | 5 (7.94) | 2.80 |
Authors | Studies |
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Adamczyk-Grochala, J; Cappello, F; Filip, K; Lauricella, M; Lewińska, A; Marino Gammazza, A; Wnuk, M | 1 |
Ahuja, N; Azad, NS; Baretti, M; Cope, L; Durham, JN; Heumann, TR; Leatherman, J; Linden, S; Lopez-Vidal, TY; Monga, DK; O'Dwyer, PJ; Reiss, KA; Sharma, A; Sugar, EA; Weekes, CD | 1 |
Acharya, NK; Badach, J; Emery, R; Hong, YK; Jelinek, J; Joneja, U; Lin, A; Madzo, J; Platoff, R; Sandilos, G; Williamson, J; Zhang, P; Zhu, C; Zilberman, B | 1 |
Diamond, DJ; Ebelt, ND; Johnson, BL; Manuel, ER; Zuniga, E | 1 |
Bouvet, M; Hamada, K; Han, Q; Hoffman, RM; Inubushi, S; Kawaguchi, K; Nishino, H; Sugisawa, N; Tan, Y; Tashiro, Y; Unno, M; Yamamoto, J | 1 |
Han, T; Hu, H; Jiao, F; Wang, LW; Zhuo, M | 1 |
Chen, LH; Dong, JY; Hu, KF; Liu, J; Ma, LZ; Peng, H; Sun, Y; Yang, QY; Yang, XL | 1 |
Gailhouste, L; Hatada, I; Liew, LC; Nakagama, H; Ochiya, T | 1 |
Bushell, MD; Godfrey, JD; Morton, JP; Sansom, OJ; Wilczynska, A | 1 |
Ahuja, N; Cai, Y; Hu, Y; Karunasena, E; Keer, H; Lerner, L; Morreale, M; Saggi, S; Sen, R; Thakar, M; Ying Lin, W | 1 |
Guo, RD; Han, X; Li, ZJ; Tan, ZJ; Wang, YL | 1 |
Abe, K; Egawa, S; Fukushige, S; Horii, A; Kaneko, N; Karasawa, H; Miura, K; Mizuguchi, Y; Morishita, K; Motoi, F; Nagase, H; Saiki, Y; Sasaki, I; Sase, T; Shibata, C; Sunamura, M; Unno, M; Yamamura, A | 1 |
Fang, JY; Jiang, N; Lu, W; Wang, H; Wang, X; Zhang, XF | 1 |
Barthet, M; Bories, E; Calvo, E; Duconseil, P; Dusetti, N; Ewald, J; Garcia, S; Gasmi, M; Gayet, O; Gilabert, M; Giovannini, M; Goncalves, A; Iovanna, J; Loncle, C; Lopez, MB; Moutardier, V; Ouaissi, M; Poizat, F; Raoul, JL; Secq, V; Turrini, O; Viens, P | 1 |
Biankin, AV; Caldon, CE; Chang, DK; Colvin, EK; Henshall, SM; Mawson, A; Musgrove, EA; Pajic, M; Pinese, M; Scarlett, CJ; Susanto, JM; Sutherland, RL | 1 |
Bintz, J; Garcia, MN; Grasso, D; Iovanna, JL; Lomberk, G; Loncle, C; Lopez, MB; Molejon, MI; Urrutia, R | 1 |
Bu, HQ; Chen, L; Chen, ZQ; Chu, YQ; Fei, Y; Lin, SZ; Liu, DL; Pan, FP; Pan, J; Tang, J; Xu, LP; Yu, QJ; Zhang, H; Zhou, HK | 1 |
Cheng, XB; Hirata, K; Koga, A; Kohi, S; Sato, N | 1 |
Han, ZB; Hao, J; Huang, C; Jia, Z; Jiang, W; Li, Y; Ren, H; Sun, Y; Wang, H; Wang, X; Xie, K; Yang, S; Zhao, T; Zheng, C | 1 |
Ammerpohl, O; Fölsch, UR; Kalthoff, H; Koch, D; Müerköster, SS; Schäfer, H; Sipos, B; Tsao, MS; Werbing, V | 1 |
Cecconi, D; Dalla Pozza, E; Donadelli, M; Palmieri, M; Righetti, PG; Rinalducci, S; Scarpa, A; Scupoli, MT; Zolla, L | 1 |
Kumari, A; Srinivasan, R; Wig, JD | 1 |
Costanzo, C; Dandrea, M; Donadelli, M; Palmieri, M; Scarpa, A | 1 |
Jagodzinski, PP; Kozłowska, A; Lianeri, M; Lutkowska, A; Pietkiewicz, PP; Przybylski, M | 1 |
Angst, E; Dawson, DW; Eibl, G; Go, VL; Hines, OJ; Nguyen, A; Park, J; Reber, HA | 1 |
Goggins, M; Hong, SM; Li, A; Omura, N | 1 |
Brom, M; Hummel-Eisenbeiss, J; Keller, D; Keppler, D; Lyko, F; Rius, M | 1 |
Gordian, E; Miller, H; Ramachandran, K; Rocha-Lima, C; Singal, R | 1 |
Cai, HH; Gao, WT; Miao, Y; Peng, Q; Sun, YM; Yao, J; Zhao, HL | 1 |
Guo, CW; Jiang, ZZ; Li, P; Li, Q; Song, K | 1 |
Chen, J; Cui, Q; Lu, Z; Zhao, L | 1 |
Amato, E; Boninsegna, L; Dandrea, M; Debattisti, V; Falconi, M; Fumagalli, C; Malpeli, G; Pelosi, G; Scarpa, A | 1 |
Nalls, D; Rodova, M; Shankar, S; Srivastava, RK; Tang, SN | 1 |
Cogdill, AP; Cooper, ZA; Ferrone, CR; Fiedler, A; Frederick, DT; Garber, HR; Rosenberg, L; Thayer, SP; Wargo, JA; Warshaw, AL | 1 |
Goggins, M; Hong, SM; Li, A; Omura, N; Vincent, A; Walter, K; Young, A; Yu, J | 1 |
Ahn, YM; Kim, SH; Kim, YS; Lee, HY; Yi, H | 1 |
Brooks, J; Cullo, A; Davies, J; Gonda, T; Hirsch, S; Kim, S; Ludwig, T; Olive, K; Quante, M; Salas, M; Shakya, R; Szabolcs, M; Tycko, B; Wang, TC | 1 |
Bert, T; Gangsauge, S; Lubomierski, N; Münch, K; Prasnikar, N; Printz, H; Robbel, C; Simon, B | 1 |
Deng, G; Han, SW; Ho, JJ; Kim, YS; Kuan, SF; Pan, PL | 1 |
Goggins, M; Maehara, N; Sato, N; Su, GH | 1 |
Brune, K; Fukushima, N; Goggins, M; Hruban, RH; Matsubayashi, H; Sahin, F; Sato, N; Walter, KM; Yeo, CJ | 1 |
Biallek, M; Jonat, W; Klöppel, G; Lüttges, J; Maass, N; Morohoshi, T; Mundhenke, C; Nagasaki, K; Ohike, N; Zhang, M | 1 |
Chow, BK; Lee, LT; Ng, SS; Pang, RT; Yung, WH | 1 |
Astner, H; Cecconi, D; Donadelli, M; Hamdan, M; Missiaglia, E; Palmieri, M; Righetti, PG; Scarpa, A | 1 |
Alder, H; Aqeilan, RI; Cesari, R; Croce, CM; Kanematsu, T; Kuroki, T; Matsuyama, A; Mori, M; Nolli, ML; Rattan, S; Trapasso, F; Williams, NN; Yendamuri, S | 1 |
Logsdon, CD; Okami, J; Simeone, DM | 1 |
Eshleman, JR; Fukushima, N; Goggins, M; Iacobuzio-Donahue, CA; Miyagi, Y; Parker, AR; Sato, N | 1 |
Crnogorac-Jurcevic, T; Donadelli, M; Lemoine, NR; Missiaglia, E; Palmieri, M; Scarpa, A | 1 |
Furukawa, T; Horii, A; Kanai, N; Sunamura, M; Xu, S | 1 |
Abe, T; Chang, R; Dhara, S; Goggins, M; Hustinx, SR; Maitra, A; Martin, ST; Sato, N | 1 |
Abe, T; Fukushima, N; Goggins, M; Matsubayashi, H; Sato, N | 1 |
Goto, M; Hamada, T; Higashi, M; Nakamura, S; Nomoto, M; Sugai, T; Tsutsumida, H; Yonezawa, S | 1 |
Imazeki, F; Kanda, T; Nagao, K; Saisho, H; Tada, M; Yokosuka, O | 1 |
Gu, J; Ide, Y; Ito, T; Kozutsumi, Y; Miyoshi, E; Nakagawa, T; Nishida, T; Tanemura, M; Taniguchi, N; Yamamoto, H | 1 |
Goto, M; Hamada, T; Higashi, M; Nomoto, M; Tsutsumida, H; Yamada, N; Yonezawa, S | 1 |
Jiang, P; Mouri, H; Ohtsubo, K; Okada, G; Sawabu, N; Tsuchiyama, T; Watanabe, H; Yao, F | 1 |
Chen, G; Wen, Q; Zhang, FQ; Zhang, TP; Zhao, YP | 1 |
Beckhove, P; Buchler, MW; Galindo-Escobedo, LV; Geng, W; Koch, M; Krempien, R; Niethammer, AG; Rimoldi, D; Romero, P; Schmitz-Winnenthal, FH; Weitz, J; Z'graggen, K | 1 |
Chumakov, A; Gery, S; Imai, Y; Kawamata, N; Koeffler, HP; Komatsu, N; Kumagai, T; Takai, N; Wakimoto, N; Yin, D | 1 |
Blann, E; Hammons, GJ; Lyn-Cook, BD; Nichols, J; Warren, GJ | 1 |
Ammanamanchi, S; Brattain, MG; Freeman, JW; Mimari, D; Venkatasubbarao, K | 1 |
Goggins, M; Hruban, RH; Issa, JP; Skinner, H; Toyota, M; Ueki, T; Walter, KM; Yeo, CJ | 1 |
Casper, ES; Kelsen, DP; Schwartz, GK | 1 |
2 trial(s) available for azacitidine and Pancreatic Neoplasms
Article | Year |
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A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Azacitidine; DNA Methylation; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pancreatic Neoplasms | 2022 |
Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Azacitidine; Female; Humans; Infusion Pumps; Male; Middle Aged; Pancreatic Neoplasms | 1992 |
61 other study(ies) available for azacitidine and Pancreatic Neoplasms
Article | Year |
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5-Azacytidine Inhibits the Activation of Senescence Program and Promotes Cytotoxic Autophagy during Trdmt1-Mediated Oxidative Stress Response in Insulinoma β-TC-6 Cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Azacitidine; Insulinoma; Methyltransferases; Mice; Oxidants; Oxidative Stress; Pancreatic Neoplasms | 2022 |
Novel treatment strategy of targeting epigenetic dysregulation in pancreatic neuroendocrine tumors.
Topics: Animals; Azacitidine; DNA; Epigenesis, Genetic; Humans; Methyltransferases; Mice; Neuroendocrine Tumors; Pancreatic Neoplasms | 2023 |
5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.
Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; DNA Transposable Elements; Humans; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms | 2020 |
Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carbon-Sulfur Lyases; Cell Proliferation; Cycloleucine; DNA Methylation; Fibrosis; Humans; Methionine; Mice, Nude; Necrosis; Pancreatic Neoplasms; Proof of Concept Study; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |
Synergistic effects of the combination of 5-Aza‑CdR and suberoylanilide hydroxamic acid on the anticancer property of pancreatic cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Pancreatic Neoplasms; Signal Transduction; Tumor Suppressor Protein p53; Up-Regulation; Vorinostat | 2018 |
[The Study of Methylated Regulation MicroRNA in Pancreatic Carcinoma Cell and Its Effect on Cell Proliferation,Migration and Invasion].
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Pancreatic Neoplasms; Promoter Regions, Genetic | 2017 |
Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells.
Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2018 |
MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genetic Loci; Humans; Mice; MicroRNAs; Mutation; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53 | 2018 |
A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent.
Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; Humans; Irinotecan; Pancreas; Pancreatic Neoplasms; Topoisomerase I Inhibitors | 2018 |
[Effect of 5-aza-2'-deoxycytidine on growth and methylation of RUNX3 gene in human pancreatic cancer cell line MiaPaca2].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; RNA, Messenger | 2013 |
Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Middle Aged; Negative Staining; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2013 |
Effect of inhibition of MEK pathway on 5-aza-deoxycytidine-suppressed pancreatic cancer cell proliferation.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA Methylation; Genes, Tumor Suppressor; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein Kinase Inhibitors | 2013 |
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.
Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Enzyme Inhibitors; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Transcriptome; Xenograft Model Antitumor Assays | 2015 |
The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.
Topics: Animals; Antineoplastic Agents; Azacitidine; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Vorinostat | 2015 |
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; Cellular Senescence; CpG Islands; DNA Methylation; DNA-Binding Proteins; Dynamin I; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung Neoplasms; Mice; Mice, Knockout; Neoplasm Proteins; Oncogenes; Pancreatic Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras) | 2015 |
Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Drug Synergism; Emodin; Enkephalins; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein Precursors; Sequence Analysis, DNA; Tumor Suppressor Proteins | 2016 |
Increased Expression of HYAL1 in Pancreatic Ductal Adenocarcinoma.
Topics: Azacitidine; Carcinoma, Pancreatic Ductal; Decitabine; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Pancreatic Neoplasms | 2016 |
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.
Topics: Animals; Antigens, CD; Azacitidine; Cadherins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Decitabine; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Promoter Regions, Genetic; Transcription Factors; Tumor Suppressor Proteins; Up-Regulation | 2017 |
Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma--epigenetic downregulation of caspases.
Topics: Animals; Apoptosis; Azacitidine; Carcinoma, Pancreatic Ductal; Caspases; Cell Line, Tumor; Cell Nucleus; Coculture Techniques; Decitabine; Deoxycytidine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Etoposide; Female; Fibroblasts; Gemcitabine; Humans; Mice; Mice, SCID; Pancreatic Neoplasms; STAT1 Transcription Factor; Transfection | 2008 |
Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study.
Topics: Analysis of Variance; Apoptosis; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; Endocrine Gland Neoplasms; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Pancreatic Neoplasms | 2009 |
Effect of c-MYC and E2F1 gene silencing and of 5-azacytidine treatment on telomerase activity in pancreatic cancer-derived cell lines.
Topics: Azacitidine; Cell Line, Tumor; DNA Methylation; E2F1 Transcription Factor; Gene Silencing; Genes, myc; Humans; Pancreatic Neoplasms; Proto-Oncogene Proteins c-myc; RNA Interference; Telomerase | 2009 |
MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines.
Topics: Adenocarcinoma; Azacitidine; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; DNA; DNA Methylation; Gene Silencing; Humans; Hydroxamic Acids; Interleukin-6; Methyl-CpG-Binding Protein 2; NF-kappa B; Pancreatic Neoplasms | 2009 |
Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; DNA, Neoplasm; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Promoter Regions, Genetic; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Analysis, DNA | 2010 |
Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells.
Topics: Azacitidine; Cell Cycle Proteins; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Pancreatic Neoplasms; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors.
Topics: Azacitidine; Catechin; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 19; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Gene Dosage; Humans; Mutation; Pancreatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins | 2010 |
Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.
Topics: Animals; Azacitidine; Biological Transport; Cell Line, Transformed; Dogs; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Nucleosides; Pancreas; Pancreatic Neoplasms; Substrate Specificity; Transfection | 2010 |
Methylation-mediated silencing of TMS1 in pancreatic cancer and its potential contribution to chemosensitivity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Cytoskeletal Proteins; Deoxycytidine; DNA Methylation; Docetaxel; Drug Resistance, Neoplasm; Drug Synergism; Gemcitabine; Gene Silencing; Humans; Pancreatic Neoplasms; Promoter Regions, Genetic; Taxoids; Transfection | 2010 |
Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines.
Topics: Apoptosis; Azacitidine; Decitabine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Gene Expression; GPI-Linked Proteins; Humans; Hydroxamic Acids; Pancreatic Neoplasms; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor, Member 10c; Restriction Mapping; Sequence Analysis, DNA; Tumor Cells, Cultured; Tumor Necrosis Factor Decoy Receptors | 2011 |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Endothelial Cells; Epithelial-Mesenchymal Transition; Heparitin Sulfate; Histones; Humans; Hydroxamic Acids; Methylation; Pancreatic Neoplasms; RNA, Messenger; Sequence Analysis, DNA; Snail Family Transcription Factors; Sulfotransferases; Transcription Factors; Transcriptional Activation | 2011 |
Aberrant methylation of RASSF2A in human pancreatic ductal adenocarcinoma and its relation to clinicopathologic features.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Cell Line; China; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Suppressor Proteins | 2012 |
Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1C in pancreatic endocrine tumors.
Topics: Adult; Aged; Azacitidine; Case-Control Studies; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Exons; Female; Gene Expression Regulation, Neoplastic; Humans; Linear Models; Male; Middle Aged; Pancreatic Neoplasms; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Statistics, Nonparametric; Tumor Suppressor Proteins; Up-Regulation | 2011 |
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.
Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatin; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Pancreatic Neoplasms; Spheroids, Cellular; Tumor Stem Cell Assay; Up-Regulation; Vorinostat | 2011 |
Targeting the MAGE A3 antigen in pancreatic cancer.
Topics: Adenocarcinoma; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokines; Decitabine; Deoxycytidine; DNA Methylation; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Male; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Receptors, Antigen, T-Cell; T-Lymphocytes; Testis; Valproic Acid | 2012 |
Unlike pancreatic cancer cells pancreatic cancer associated fibroblasts display minimal gene induction after 5-aza-2'-deoxycytidine.
Topics: ADAM Proteins; ADAM12 Protein; Azacitidine; Base Sequence; Blotting, Western; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genetic Association Studies; Humans; Immunohistochemistry; Male; Membrane Proteins; Middle Aged; Molecular Sequence Data; Pancreatic Neoplasms; RNA, Messenger; Sequence Analysis, DNA; Up-Regulation | 2012 |
Haloperidol induces demethylation and expression of the dual specificity phosphatase 6 gene in MIA PaCa-2 human pancreatic cancer cells.
Topics: Antipsychotic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 6; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Haloperidol; Humans; Introns; Molecular Sequence Data; Pancreatic Neoplasms | 2012 |
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; Decitabine; DNA Methylation; Female; Humans; Male; Mice; Mice, Transgenic; Pancreatic Neoplasms; Stromal Cells | 2013 |
Expression spectrum and methylation-dependent regulation of melanoma antigen-encoding gene family members in pancreatic cancer cells.
Topics: Adult; Aged; Antigens, Neoplasm; Azacitidine; Culture Techniques; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression; Gene Expression Regulation; Humans; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2002 |
Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Azacitidine; Base Sequence; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucins; Neoplasm Invasiveness; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm | 2003 |
Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinases; Methylation; Neoplasm Invasiveness; Pancreatic Neoplasms; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Methylation of cyclin D2 is observed frequently in pancreatic cancer but is also an age-related phenomenon in gastrointestinal tissues.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cyclin D2; Cyclins; Decitabine; Digestive System; DNA Methylation; Female; Humans; Male; Middle Aged; Pancreatic Juice; Pancreatic Neoplasms; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transfection | 2003 |
Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas.
Topics: Acetylation; Aged; Azacitidine; Carcinoma, Pancreatic Ductal; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Promoter Regions, Genetic; Proteins; Serpins; Tumor Cells, Cultured; Up-Regulation | 2003 |
CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.
Topics: Adenocarcinoma; Animals; Azacitidine; Base Composition; Base Sequence; Cattle; Cells, Cultured; CpG Islands; Cytosine; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Drosophila; Enzyme Inhibitors; Gene Expression Regulation; Humans; Molecular Sequence Data; Pancreatic Neoplasms; Promoter Regions, Genetic; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Regulatory Sequences, Nucleic Acid; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription Factors | 2004 |
Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine.
Topics: Actin Depolymerizing Factors; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Division; Contractile Proteins; Cyclin-Dependent Kinase Inhibitor p16; Cyclophilin A; Cystatin B; Cystatins; Decitabine; DNA Methylation; Humans; Mass Spectrometry; Microfilament Proteins; Pancreatic Neoplasms; Profilins; Promoter Regions, Genetic; Proteomics; Rosaniline Dyes; Superoxide Dismutase; Tumor Cells, Cultured | 2003 |
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
Topics: Adenocarcinoma; Alleles; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Separation; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; DNA Mutational Analysis; DNA, Complementary; Exons; Flow Cytometry; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Oxidoreductases; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2004 |
Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer.
Topics: Adenocarcinoma; Apoptosis; Azacitidine; Cell Hypoxia; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Glucose Transport Proteins, Facilitative; Humans; Insulin-Like Growth Factor Binding Protein 3; Membrane Proteins; Monosaccharide Transport Proteins; Pancreas; Pancreatic Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins; Tumor Cells, Cultured | 2004 |
Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Decitabine; DNA Primers; Glycoproteins; Humans; Hydroxamic Acids; Loss of Heterozygosity; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous | 2005 |
Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2'-deoxycytidine treatment is associated with activation of the interferon signalling pathway.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Cisplatin; Decitabine; Deoxycytidine; DNA Methylation; DNA Modification Methylases; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Interferon-gamma; Interferons; Pancreatic Neoplasms; Signal Transduction | 2005 |
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Topics: Acetylation; Adenocarcinoma; Azacitidine; Base Sequence; Carcinoma, Pancreatic Ductal; Cell Differentiation; CpG Islands; DNA Methylation; Dual Specificity Phosphatase 6; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Tyrosine Phosphatases; Tumor Cells, Cultured | 2005 |
Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2005 |
Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling.
Topics: Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cluster Analysis; Cyclin-Dependent Kinase Inhibitor p57; Decitabine; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing.
Topics: Azacitidine; Colon; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Mucin-2; Mucins; Pancreatic Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Sequence Analysis, DNA; Sp1 Transcription Factor; Sulfites; Tumor Cells, Cultured | 2005 |
5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Decitabine; DNA; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorouracil; HeLa Cells; Humans; Liver Neoplasms; Pancreatic Neoplasms; Prognosis; Time Factors; Treatment Outcome; Trypan Blue | 2005 |
Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Northern; Butyrates; Cell Line, Tumor; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Male; Models, Biological; N-Acetylglucosaminyltransferases; Oligonucleotide Array Sequence Analysis; Oligosaccharides; Pancreas; Pancreatic Neoplasms; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2006 |
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer.
Topics: Azacitidine; Cell Line, Tumor; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Mucin-2; Mucins; Pancreatic Neoplasms; Promoter Regions, Genetic; RNA, Messenger | 2006 |
Diagnostic utility of aberrant methylation of tissue factor pathway inhibitor 2 in pure pancreatic juice for pancreatic carcinoma.
Topics: Adenocarcinoma, Mucinous; Aged; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Pancreatic Ductal; Carcinoma, Papillary; Cell Line, Tumor; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Male; Middle Aged; Pancreatic Juice; Pancreatic Neoplasms; Pancreatitis, Chronic; Polymerase Chain Reaction; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm | 2006 |
[Expression of S100A2 in secondarily radioresistant pancreatic cancer cells and significance thereof].
Topics: Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Survival; Chemotactic Factors; Decitabine; Down-Regulation; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S100 Proteins | 2006 |
Potential target antigens for immunotherapy in human pancreatic cancer.
Topics: Adenocarcinoma; Antigens, Neoplasm; Azacitidine; Base Sequence; DNA Primers; Humans; Immunotherapy; Pancreatic Neoplasms | 2007 |
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
Topics: Annexin A5; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Methylation; Pancreatic Neoplasms; Vorinostat | 2007 |
Increased DT-diaphorase activity in transformed and tumorigenic pancreatic acinar cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; In Vitro Techniques; Methylation; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1995 |
Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Chloramphenicol O-Acetyltransferase; Decitabine; DNA Modification Methylases; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Pancreatic Neoplasms; Plicamycin; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Sp1 Transcription Factor; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; Cyclin G; Cyclin G1; Cyclins; DNA Methylation; Enkephalins; Humans; Microsatellite Repeats; Middle Aged; Pancreatic Neoplasms; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction | 2001 |