azacitidine has been researched along with Metastase in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (16.48) | 18.7374 |
| 1990's | 9 (9.89) | 18.2507 |
| 2000's | 21 (23.08) | 29.6817 |
| 2010's | 43 (47.25) | 24.3611 |
| 2020's | 3 (3.30) | 2.80 |
| Authors | Studies |
|---|---|
| Augustin, RC; Bahary, N; Beasley, HS; Chu, E; Hartman, DJ; Herman, JG; Krishnamurthy, A; Kuang, C; Lee, JJ; Lin, Y; Marks, SM; Ohr, J; Pai, RK; Park, Y; Rhee, JC; Seigh, L; Shuai, Y; Sun, W; Zarour, HM | 1 |
| Chunmeng, M; Hasnat, M; Le, L; Luyong, Z; Qinwei, Y; Qipeng, W; Zhenzhou, J | 1 |
| Amato, G; Anichini, A; Azab, M; Bock, C; Coral, S; Covre, A; Cutaia, O; Danielli, R; Di Giacomo, AM; Fazio, C; Finotello, F; Fridman, WH; Giannarelli, D; Lacroix, L; Lazzeri, A; Lowder, J; Maio, M; Miracco, C; Monterisi, S; Nemc, A; Oganesian, A; Petitprez, F; Rieder, D; Sautès-Fridman, C; Sigalotti, L; Trajanoski, Z; Valente, M | 1 |
| Battafarano, RJ; Baylin, SB; Brahmer, JR; Brock, MV; Broderick, SR; Bush, EL; Cai, Y; Cattaneo, SM; Cui, Y; Day, CP; Easwaran, H; Forde, PM; Housseau, F; Huang, P; Hulbert, A; Jiao, X; Juergens, RA; Kim, K; Kim, YJ; Kong, X; Lee, B; Li, H; Li, S; Lu, Z; Margolick, JB; Mei, Y; Nelkin, BD; Pardoll, DM; Riemer, JB; Rodgers, K; Rudin, CM; Shen, L; Tao, Y; Topper, MJ; Vaz, M; Wang, KK; Wang, Y; Wrangle, J; Xia, L; Xie, W; Yang, SC; Yen, RC; Zahnow, CA; Zhang, B; Zhang, H; Zhang, W; Zou, J | 1 |
| Baura, VA; Biembengut, IV; Chequin, A; Costa, FF; de O Pedrosa, F; de Souza, EM; Klassen, G; Klassen, LMB; Manica, GCM; Ramos, EAS; Toledo, MB | 1 |
| Ding, C; Dong, Z; Guo, W; Guo, Y; Liang, J; Liu, S; Shan, B; Shen, S | 1 |
| Choi, SD; Jeon, S; Jeong, D; Kim, H; Nam, GH; Ryu, A; Sunwoo, J | 1 |
| He, TC; Liu, JX; Shao, ZW; Sheng, W; Shi, DY; Wang, BC; Wu, Q; Yang, SH; Zhang, ZC | 1 |
| Doi, A; Fujii, T; Irie, S; Matsui, T; Ohno, N; Sahara, N; Sakamoto, N | 1 |
| Biyani, N; Bolt, MJ; Chlenski, A; Forde, M; Jutzy, JMS; Khodarev, NN; Oshima, G; Pitroda, SP; Poli, EC; Posner, MC; Weichselbaum, RR | 1 |
| Liu, J; Liu, L; Liu, X; Zhang, S | 1 |
| Boucher, K; Burr, L; Davidson, C; Garrido-Laguna, I; Gilcrease, W; Jakubowski, L; Jones, D; McGregor, KA; Morrell, G; Olpin, JD; Sharma, S; Soldi, R; Wade, M; Weis, J | 1 |
| Antonicelli, F; Diederich, M; Doliwa, C; Dufer, J; Poplineau, M; Schnekenburger, M; Trussardi-Régnier, A | 1 |
| Brewer, MA; Meng, F; Sun, G; Yu, Y; Zhong, M | 1 |
| Ge, YL; Han, LL; Hou, L; Lin, DL; Ma, ZL; Wu, L; Zhou, MJ | 1 |
| Ahn, JH; Choi, EN; Choi, HJ; Ju, W; Kim, NH; Lyu, D; Sung, HY | 1 |
| Cui, L; Dong, Z; Guo, W; Guo, Y; Kuang, G; Shen, S; Wang, C | 1 |
| Adel Fahmideh, M; Fotouhi, O; Hashemi, J; Höög, A; Kjellman, M; Larsson, C; Sulaiman, L; Zedenius, J | 1 |
| Bernasconi, MJ; Frederick, DT; Gunda, V; Parangi, S; Wargo, JA | 1 |
| Ahn, JH; Choi, EN; Ju, W; Lyu, D; Park, AK; Sung, HY | 1 |
| Blosser, RL; Diaz, LA; Kim, K; Kinzler, KW; Li, Z; Liu, Q; Papadopoulos, N; Skora, AD; Tam, AJ; Vogelstein, B; Zhou, S | 1 |
| Boureau, L; Cheishvili, D; Szyf, M | 1 |
| Gordian, E; Quintero, C; Ramachandran, K; Reis, IM; Singal, R; Zhao, W | 1 |
| Ahn, JH; Ju, W; Sung, HY | 1 |
| Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J | 1 |
| Cao, Y; Chen, H; Jiang, M; Jie, Z; Le, Z; Li, D; Li, Z; Liu, Y; Tan, S; Xiong, J; Zhang, G | 1 |
| Drzewiecka, H; Dyszkiewicz, W; Gałęcki, B; Jagodziński, PP; Jarmołowska-Jurczyszyn, D; Kluk, A | 1 |
| Bendinelli, P; Desiderio, MA; Disanza, A; Maroni, P; Matteucci, E | 1 |
| Anaka, M; Behren, A; Cebon, J; Chueh, AC; Davalos-Salas, M; Jayachandran, A; Lo, PH; Molania, R; Prithviraj, P; Walkiewicz, M | 1 |
| Balaji, KC; Lin, HK; Liu, Y; Pochampally, R; Said, N; Sharma, S; Shiozawa, Y; Watabe, K; Wu, K; Xing, F | 1 |
| He, Y; Huang, C; Huang, K; Li, Z; Liu, H; Ye, G; Zhou, X | 1 |
| He, H; He, Y; Jiang, D; Li, W; Ma, H; Niu, Z; Wu, D; Xie, X; Zuo, X | 1 |
| Bisogno, G; Celegato, B; Lanfranchi, G; Martini, P; Millino, C; Pacchioni, B; Poli, E; Romualdi, C; Rosolen, A; Tombolan, L; Zin, A | 1 |
| Han, ZB; Hao, J; Huang, C; Jia, Z; Jiang, W; Li, Y; Ren, H; Sun, Y; Wang, H; Wang, X; Xie, K; Yang, S; Zhao, T; Zheng, C | 1 |
| Annereau, M; Auger, N; Bermudez, E; Chahine, C; Danu, A; de Botton, S; Desmaris, RP; El Halabi, L; Ghez, D; Lazarovici, J; Leary, A; Lemare, F; Micol, JB; Pistilli, B; Saada, V; Solary, E; Willekens, C | 1 |
| Bendinelli, P; Desiderio, MA; Maroni, P; Matteucci, E | 1 |
| Csiszar, K; Fong, KS; Fong, SF; Hollosi, P; Yakushiji, JK | 1 |
| Foster, BA; Karpf, AR; Mavis, CK; Morey Kinney, SR | 1 |
| Beder, LB; Fujihara, K; Fukushima, K; Grenman, R; Gunduz, E; Gunduz, M; Hotomi, M; Shimada, J; Shimizu, K; Tamura, S; Yamanaka, N; Yaykasli, K | 1 |
| Ibrahim, SM; Kunz, M; Schultz, J; Vera, J | 1 |
| Huang, G; Kleinerman, ES; Koshkina, NV | 1 |
| Egan, LJ; Foran, E; Garrity-Park, MM; Limburg, PJ; Mureau, C; Newell, J; Smyrk, TC | 1 |
| Baba, T; Fujii, N; Hamanishi, J; Kang, HS; Kharma, B; Kondoh, E; Konishi, I; Mandai, M; Matsumura, N; Murphy, SK; Oishi, S; Yoshioka, Y | 1 |
| Cronk, RJ; Lang, JM; McNeel, DG; Smith, HA | 1 |
| Akahira, J; Hiroki, E; Ito, K; Miki, Y; Nagase, S; Sasano, H; Sugawara, J; Suzuki, F; Suzuki, T; Yaegashi, N | 1 |
| Li, CL; Li, JF; Liu, BY; Nie, H; Qu, QL; Su, LP; Wang, M; Yan, M; Yu, YY; Zhu, ZG | 1 |
| Bardhan, K; Liu, K; McGaha, TL; Torres, CM; Yang, D; Zimmerman, M | 1 |
| Chen, H; Li, Q | 1 |
| Bischoff, J; Costa, SD; Ignatov, A; Ignatov, T; Krebs, T; Küster, D; Przadka-Rabaniuk, D; Roessner, A; Schneider-Stock, R; Schwarzenau, C; Semczuk, A | 1 |
| Bernardo, V; da Silva, DC; de Souza, CF; Jasiulionis, MG; Lopes, JD; Mai, S; Monteiro, AC; Silva, AG; Xander, P | 1 |
| Beumer, JH; Buch, SC; Christner, S; Egorin, MJ; Kirkwood, JM; Lin, Y; Moschos, S; Tarhini, AA; Tawbi, HA | 1 |
| Demers, M; Magnaldo, T; Mercier, J; Moisan, S; Potworowski, EF; St-Pierre, Y | 1 |
| Hirohashi, S; Ino, Y; Kanai, Y; Nam, JS; Sakamoto, M | 1 |
| Endoh, M; Honda, T; Motoyama, T; Nishizuka, S; Tamura, G; Yanagawa, N | 1 |
| Bakin, AV; Li, X; Quan, L; Safina, AF; Sossey-Alaoui, K; Stourman, NV; Varga, AE; Zheng, Q | 1 |
| Bhattacharya, M; Chakraborty, AK; Chakraborty, D; Chatterjee, A; Funasaka, Y; Pawelek, J; Sousa, Jde F | 1 |
| Chen, W; Jiang, B; Jiang, JD; Liu, H; Liu, J; Liu, W; Luo, C; Wang, L; Wu, Y; Xue, R; Zhao, W; Zhou, Y | 1 |
| Furuta, J; Kikuchi, K; Miyagi, Y; Nakagawa, H; Nakanishi, Y; Nobeyama, Y; Okochi-Takada, E; Ushijima, T; Yamamoto, A | 1 |
| Bennett, KL; Eng, C; Hackanson, B; Lang, JC; Morrison, CD; Plass, C; Schuller, DE; Smith, LT; Weber, F | 1 |
| Erickson, LA; Erlichman, C; Hobday, TJ; Jin, L; Lloyd, RV; Nakamura, N; Ruebel, KH; Rumilla, KM; Stilling, GA; Zhang, HY | 1 |
| Ateeq, B; Rabbani, SA; Szyf, M; Unterberger, A | 1 |
| Chen, XP; Gutmann, DH; Huang, ZY; Xiao, ZY; Xiong, M; Yan, Q; Zhang, ZF | 1 |
| Glaubiger, DL; LeVine, AS; Poplack, DG; Reaman, GH; Srinivasan, U | 1 |
| Forchhammer, J; Olsson, L | 1 |
| Carlow, DA; Elliott, BE; Frost, P; Kerbel, RS; Liteplo, R | 1 |
| Herlyn, M; Johnson, B; Lassam, N; Rosenberg, SA; Salgaller, M; Samid, D; Treisman, J; Weber, J | 1 |
| Georgiev, G; Grigorian, M; Lukanidin, E; Tkatch, T; Tulchinsky, E | 1 |
| Benfield, JR; Hammond, WG | 1 |
| Baylin, SB; Bova, GS; Cairns, P; Ewing, CM; Herman, JG; Isaacs, WB; Jarrard, DF; Nguyen, SH; Pin, SS; Sidransky, D | 1 |
| Ayoub, J; Belanger, K; Bouffard, DY; Dionne, J; Momparler, LF; Momparler, RL | 1 |
| Chen, PW; Ksander, BR; Murray, TG; Reddy, R; Salgaller, ML; Uno, T | 1 |
| Culp, LA; Kogerman, P; Sy, MS | 1 |
| Nakamura, N; Takenaga, K | 1 |
| Clare, SE; Clark, G; Elkahloun, AG; Hartsough, MT; Mair, M; Osborne, CK; Sgroi, D; Steeg, PS | 1 |
| Ahlborn, TE; Gupta, A; Li, C; Liu, J; Lu, A; Ma, Y; Shi, EY | 1 |
| Akakura, K; Ichikawa, T; Igarashi, T; Ito, H; Kito, H; Nakayama, T; Sekita, N; Shiraishi, T; Suzuki, H; Toyota, M; Watanabe, M; Yoshie, O | 1 |
| Ashida, T; Fujiki, T; Fujiya, M; Honda, M; Kohgo, Y; Saitoh, Y; Tanabe, H; Watari, J | 1 |
| Ono, K; Suzuki, H; Tanaka, C; Tanzawa, H; Uzawa, K; Yakushiji, T; Yamamoto, N; Yokoe, H | 1 |
| Goldstein, JH; Israili, ZH; Mingioli, ES; Pirkle, JL; Smithwick, RW; Vogler, WR | 1 |
| Keller, JW; Miller, DS; Vogler, WR | 1 |
| Arkun, SN; Bartolucci, AA; Vélez-Garcia, E; Vogler, WR | 1 |
| Bellet, RE; Berd, D; Catalano, RB; Mastrangelo, MJ | 1 |
| Bassin, RH; Rimoldi, D; Samid, D; Srikantan, V; Wilson, VL | 1 |
| Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL | 1 |
| Everett, CA; Hart, IR; Ormerod, EJ | 1 |
| Lieberman, AP; Ware, JL; Webb, KS | 1 |
| Everett, CA; Finch, M; Hart, IR; Ormerod, EJ | 1 |
| Hamada, J; Hosokawa, M; Ishikawa, M; Kobayashi, H; Okada, F | 1 |
| Takenaga, K | 1 |
| Frost, P; Hunt, B; Kerbel, RS; Man, S; Pathak, S | 1 |
| Ware, JL | 1 |
4 review(s) available for azacitidine and Metastase
| Article | Year |
|---|---|
DNA demethylation and invasive cancer: implications for therapeutics.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms | 2015 |
Possible epigenetic mechanisms of tumor progression: induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment.
Topics: Animals; Azacitidine; DNA; Ethyl Methanesulfonate; Humans; Mammary Neoplasms, Experimental; Methylation; Methylnitronitrosoguanidine; Models, Genetic; Mutation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Phenotype; Stem Cells | 1984 |
Hamster bronchial carcinogenesis induced by carcinogen-containing sustained release implants placed endobronchially: a clinically relevant model.
Topics: Animals; Azacitidine; Bronchial Neoplasms; Carcinogens; Cricetinae; Disease Models, Animal; Doxorubicin; Drug Implants; Humans; Mesocricetus; Mycobacterium bovis; Neoplasm Metastasis | 1993 |
Modification of the metastatic potential of tumor cells by drugs.
Topics: Animals; Azacitidine; Butyrates; Butyric Acid; Carcinoma; Cell Division; Cell Line; Cells, Cultured; Dimethyl Sulfoxide; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Cells, Circulating; Phenotype | 1986 |
7 trial(s) available for azacitidine and Metastase
| Article | Year |
|---|---|
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Biomarkers; Colorectal Neoplasms; Epigenomics; Female; Humans; Immunotherapy; Male; Middle Aged; Neoplasm Metastasis | 2022 |
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; CD8-Positive T-Lymphocytes; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Ipilimumab; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Patient Safety; Programmed Cell Death 1 Receptor; Survival Rate; Treatment Outcome | 2019 |
A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; ErbB Receptors; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins | 2013 |
Phase I/II study of azacitidine, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Cycle Proteins; DNA Methylation; Docetaxel; Dose-Response Relationship, Drug; Humans; Male; Neoplasm Metastasis; Nuclear Proteins; Prednisone; Prostatic Neoplasms, Castration-Resistant; Survival Analysis; Taxoids; Treatment Outcome | 2015 |
Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; Disease-Free Survival; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Skin Neoplasms; Temozolomide | 2013 |
Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Decitabine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Tumor Cells, Cultured | 1997 |
Twice weekly 5-azacytidine infusion in dissmeinated metastatic cancer: a phase II study.
Topics: Azacitidine; Clinical Trials as Topic; Drug Evaluation; Granulocytes; Humans; Infusions, Parenteral; Leukopenia; Nausea; Neoplasm Metastasis | 1977 |
80 other study(ies) available for azacitidine and Metastase
| Article | Year |
|---|---|
5-Azacytidine promotes HCC cell metastasis by up-regulating RDH16 expression.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methyltransferases; Neoplasm Metastasis | 2023 |
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
Topics: Animals; Azacitidine; Benzamides; Cell Differentiation; Cell Movement; Chemotherapy, Adjuvant; Disease Models, Animal; Down-Regulation; Epigenesis, Genetic; Genetic Therapy; Mice; Myeloid-Derived Suppressor Cells; Neoplasm Metastasis; Neoplasms; Pyridines; Receptors, CCR2; Receptors, Interleukin-8B; Tumor Microenvironment | 2020 |
MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; Promoter Regions, Genetic; Sequence Analysis, DNA | 2018 |
Aberrant methylation-mediated silencing of lncRNA CTC-276P9.1 is associated with malignant progression of esophageal squamous cell carcinoma.
Topics: Adult; Aged; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; CpG Islands; Disease Progression; DNA Methylation; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Silencing; Humans; Luciferases; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; RNA, Long Noncoding; Sp1 Transcription Factor; Survival Analysis; Up-Regulation | 2018 |
Loss of RUNX3 is significantly associated with advanced tumor grade and stage in endometrial cancers.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Promoter Regions, Genetic; RNA, Messenger | 2018 |
Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; Chondrosarcoma; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Eye Proteins; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Structure-Activity Relationship; Wnt Signaling Pathway | 2018 |
[Azacitidine for Therapy-Related Myelodysplastic Syndrome Following Oxaliplatin (L-OHP)Therapy for Metastatic Rectal Cancer].
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Combined Modality Therapy; Fatal Outcome; Humans; Leucovorin; Male; Myelodysplastic Syndromes; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Rectal Neoplasms | 2018 |
DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs.
Topics: Animals; Azacitidine; Chromosomes, Human, Pair 14; Colorectal Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; Heterografts; Humans; Liver Neoplasms; MCF-7 Cells; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; RNA, Long Noncoding | 2019 |
Aberrant promoter 2 methylation‑mediated downregulation of protein tyrosine phosphatase, non‑receptor type 6, is associated with progression of esophageal squamous cell carcinoma.
Topics: Adult; Aged; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; CpG Islands; Disease Progression; DNA Methylation; Epigenesis, Genetic; Esophageal Squamous Cell Carcinoma; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6 | 2019 |
Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatin Assembly and Disassembly; Decitabine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Fibrosarcoma; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Image Cytometry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Neoplasm Proteins | 2013 |
Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3.
Topics: Acetylation; Animals; Ascites; Azacitidine; Cadherins; Carcinogenesis; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C3H; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Ovarian Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured; Twist-Related Protein 1 | 2013 |
Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Neoplasm Metastasis; Promoter Regions, Genetic | 2013 |
Aberrant DNA methylation in the IFITM1 promoter enhances the metastatic phenotype in an intraperitoneal xenograft model of human ovarian cancer.
Topics: Animals; Antigens, Differentiation; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Ovarian Neoplasms; Ovary; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2014 |
Decreased expression of RASSF1A and up-regulation of RASSF1C is associated with esophageal squamous cell carcinoma.
Topics: Adult; Aged; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Esophageal Neoplasms; Exons; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins | 2014 |
Global hypomethylation and promoter methylation in small intestinal neuroendocrine tumors: an in vivo and in vitro study.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Chromosomes, Human, Pair 18; Cluster Analysis; DNA (Cytosine-5-)-Methyltransferases; DNA Copy Number Variations; DNA Methylation; Female; Genome, Human; Humans; Intestinal Neoplasms; Intestine, Small; Long Interspersed Nucleotide Elements; Male; Neoplasm Metastasis; Neuroendocrine Tumors; Promoter Regions, Genetic; RNA, Messenger; Survival Rate; Tumor Suppressor Proteins | 2014 |
A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Coculture Techniques; Cytoplasm; Decitabine; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Granzymes; Humans; Immunotherapy; Interferon-gamma; Lymphocytes; Membrane Proteins; Methylation; Mice; Mice, SCID; Neoplasm Metastasis; Polymerase Chain Reaction; Receptors, Antigen, T-Cell; RNA, Messenger; Thyroid Neoplasms | 2014 |
Aberrant hypomethylation-mediated AGR2 overexpression induces an aggressive phenotype in ovarian cancer cells.
Topics: Animals; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mucoproteins; Neoplasm Metastasis; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Oncogene Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; Proteins | 2014 |
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
Topics: Animals; Antibodies, Monoclonal; Azacitidine; Benzamides; Cell Line, Tumor; Colorectal Neoplasms; Combined Modality Therapy; CTLA-4 Antigen; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Myeloid Cells; Neoplasm Metastasis; Phosphoinositide-3 Kinase Inhibitors; Programmed Cell Death 1 Receptor; Pyridines | 2014 |
DNA hypomethylation-mediated overexpression of carbonic anhydrase 9 induces an aggressive phenotype in ovarian cancer cells.
Topics: Animals; Azacitidine; Carbonic Anhydrases; Carcinoma, Ovarian Epithelial; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phenotype; Promoter Regions, Genetic; RNA, Messenger | 2014 |
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin | 2014 |
Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Gene Silencing; Genes, Tumor Suppressor; Humans; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Sequence Analysis, DNA; Stomach Neoplasms | 2015 |
Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer.
Topics: Adult; Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Estradiol Dehydrogenases; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic; Tumor Burden | 2015 |
Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
Topics: Animals; Azacitidine; Bone Neoplasms; Breast Neoplasms; DNA Methylation; DNA, Neoplasm; Endothelin-1; Female; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasm Proteins; Osteonectin; RNA, Neoplasm; Tumor Microenvironment | 2016 |
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Transketolase; Up-Regulation | 2016 |
Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone.
Topics: Animals; Azacitidine; Bone Morphogenetic Protein 7; Bone Neoplasms; Cell Line, Tumor; DNA Methylation; DNA, Neoplasm; Humans; Male; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Osteonectin; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Microenvironment | 2016 |
Downregulation of thrombospondin-1 by DNA hypermethylation is associated with tumor progression in laryngeal squamous cell carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Decitabine; Disease Progression; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Thrombospondin 1; Transcriptional Activation | 2016 |
5-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1.
Topics: Antigens, CD; Azacitidine; Cadherins; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Promoter Regions, Genetic; SOXF Transcription Factors; Up-Regulation | 2016 |
Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma.
Topics: Azacitidine; Biopsy; Cell Adhesion Molecules, Neuronal; Cell Line, Tumor; Cluster Analysis; Cytidine Triphosphate; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Hydroxamic Acids; Neoplasm Metastasis; Neuropeptides; Promoter Regions, Genetic; Protocadherins; Receptors, Cell Surface; Rhabdomyosarcoma; Transcriptome | 2016 |
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.
Topics: Animals; Antigens, CD; Azacitidine; Cadherins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Decitabine; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Promoter Regions, Genetic; Transcription Factors; Tumor Suppressor Proteins; Up-Regulation | 2017 |
Use of 5-azacitidine for therapy-related myeloid neoplasms in patients with concomitant active neoplastic disease.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Neoplasms, Second Primary; Remission Induction; Retrospective Studies; Survival Rate; Treatment Outcome | 2017 |
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Topics: Animals; Azacitidine; Bone Neoplasms; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Nucleus; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Nuclear Proteins; Proto-Oncogene Proteins c-met; Signal Transduction; Tumor Microenvironment; Tumor Suppressor Proteins | 2017 |
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Topics: Amino Acid Oxidoreductases; Azacitidine; Blotting, Western; Breast Neoplasms; Catalysis; Cell Line; Cell Line, Tumor; Decitabine; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Immunohistochemistry; Mammary Glands, Human; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Drug Combinations; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Glutathione Transferase; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Prostate; Prostatic Neoplasms; RNA, Messenger | 2009 |
T-lymphocyte maturation-associated protein gene as a candidate metastasis suppressor for head and neck squamous cell carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Heterozygote; Humans; Male; Membrane Transport Proteins; Middle Aged; Mutation; Myelin and Lymphocyte-Associated Proteolipid Proteins; Myelin Proteins; Neoplasm Metastasis; Proteolipids; RNA, Messenger | 2009 |
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.
Topics: 14-3-3 Proteins; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cellular Senescence; CpG Islands; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Exonucleases; Exoribonucleases; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Neoplasm Metastasis; Neoplasm Proteins; Phenylbutyrates; RNA, Messenger | 2009 |
Fas expression in metastatic osteosarcoma cells is not regulated by CpG island methylation.
Topics: Azacitidine; Cell Line, Tumor; Cell Survival; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Introns; Neoplasm Metastasis; Osteosarcoma; Promoter Regions, Genetic | 2009 |
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Topics: Azacitidine; Carcinogenicity Tests; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-6; Neoplasm Metastasis; Promoter Regions, Genetic; Up-Regulation | 2010 |
GPR54 is a target for suppression of metastasis in endometrial cancer.
Topics: Animals; Azacitidine; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; Endometrial Neoplasms; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Kisspeptins; Mice; Mice, Nude; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Prognosis; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2011 |
Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cancer Vaccines; Cell Line, Tumor; Decitabine; Epitopes; Female; Gene Expression Regulation, Neoplastic; HLA-A2 Antigen; HLA-DR1 Antigen; Humans; Immunotherapy; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Molecular Targeted Therapy; Multigene Family; Neoplasm Metastasis; Neoplasm Proteins; Prostatic Neoplasms; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; T-Cell Antigen Receptor Specificity | 2011 |
MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma.
Topics: Adenocarcinoma; Apoptosis; Azacitidine; Cell Cycle; Cell Division; Cell Line, Tumor; Decitabine; DNA Methylation; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Immunohistochemistry; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.
Topics: 3' Untranslated Regions; Azacitidine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HEK293 Cells; Humans; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Smad2 Protein; Stomach Neoplasms | 2012 |
Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo.
Topics: Adaptor Proteins, Signal Transducing; Adoptive Transfer; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; bcl-X Protein; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Colonic Neoplasms; Decitabine; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Membrane Proteins; Mice; Mitochondrial Proteins; Neoplasm Metastasis; Neoplasms, Experimental; Proto-Oncogene Proteins; Tumor Escape; Vorinostat | 2012 |
Silencing of Wnt5a during colon cancer metastasis involves histone modifications.
Topics: Azacitidine; Cell Line, Tumor; Colonic Neoplasms; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasm Metastasis; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Wnt Proteins; Wnt-5a Protein | 2012 |
hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA, Neoplasm; Endometrial Neoplasms; Female; Humans; Microsatellite Instability; Microsatellite Repeats; Middle Aged; MutL Protein Homolog 1; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Proteins; Nuclear Proteins; Phenotype; Prognosis; Promoter Regions, Genetic | 2012 |
Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.
Topics: Animals; Azacitidine; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Hydroxamic Acids; Karyotyping; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Phenotype; Risk; Skin Neoplasms | 2012 |
Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Disease Progression; Female; Galectins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Lymphoma, T-Cell; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Oligonucleotide Array Sequence Analysis; RNA, Messenger; RNA, Neoplasm; Specific Pathogen-Free Organisms; Thymus Neoplasms; Tumor Cells, Cultured | 2003 |
5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis.
Topics: Azacitidine; Blotting, Western; Cadherins; Calcium; Cell Line, Tumor; Cell Movement; Decitabine; DNA Primers; Gene Silencing; Humans; Neoplasm Metastasis; Polymerase Chain Reaction | 2004 |
Demethylation of the synuclein gamma gene CpG island in primary gastric cancers and gastric cancer cell lines.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Division; Cell Line, Tumor; CpG Islands; Decitabine; Disease Progression; DNA Methylation; DNA, Complementary; Exons; Female; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Neoplasm Metastasis; Nerve Tissue Proteins; Polymorphism, Single-Stranded Conformational; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Sulfites; Synucleins; Time Factors | 2004 |
Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Exons; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Introns; Molecular Sequence Data; Neoplasm Metastasis; Promoter Regions, Genetic; RNA, Messenger; Transforming Growth Factor beta; Tropomyosin | 2005 |
GnT-V expression and metastatic phenotypes in macrophage-melanoma fusion hybrids is down-regulated by 5-Aza-dC: evidence for methylation sensitive, extragenic regulation of GnT-V transcription.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Consensus Sequence; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Macrophages, Peritoneal; Melanoma, Experimental; Mice; Mice, Inbred DBA; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Neoplasm Metastasis; Phenotype; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transcription, Genetic | 2006 |
Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.
Topics: Adult; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; gamma-Synuclein; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Staging | 2006 |
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.
Topics: Azacitidine; Cell Line, Tumor; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation; Gene Silencing; Glycoproteins; Humans; Immunohistochemistry; Melanoma; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Ultraviolet Rays | 2007 |
Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma.
Topics: Azacitidine; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Head and Neck Neoplasms; Humans; Loss of Heterozygosity; Neoplasm Metastasis; Transfection | 2007 |
Association of DNA methylation and epigenetic inactivation of RASSF1A and beta-catenin with metastasis in small bowel carcinoid tumors.
Topics: Azacitidine; beta Catenin; Blotting, Western; Carcinoid Tumor; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Mutational Analysis; Enterochromaffin Cells; Epigenesis, Genetic; Humans; Immunohistochemistry; Intestinal Neoplasms; Neoplasm Metastasis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2006 |
Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo.
Topics: Animals; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; gamma-Synuclein; Gene Silencing; Humans; Mice; Neoplasm Metastasis; Neoplasm Proteins; Promoter Regions, Genetic; Receptors, CXCR4; Urokinase-Type Plasminogen Activator | 2008 |
Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma.
Topics: Adult; Aged; Azacitidine; Cadherins; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2008 |
Phase II study of 5-azacytidine in sarcomas of bone.
Topics: Adolescent; Adult; Azacitidine; Bone Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukocyte Count; Male; Neoplasm Metastasis; Neutropenia; Osteosarcoma; Platelet Count; Sarcoma, Ewing; Thrombocytopenia | 1982 |
Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; DNA, Neoplasm; Methylation; Mice; Neoplasm Metastasis; Neoplasms, Experimental | 1984 |
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Cell Line; Cytotoxicity, Immunologic; Decitabine; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Lymphocytes; Lymphocytes, Tumor-Infiltrating; Melanocytes; Melanoma; Melanoma-Specific Antigens; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured | 1994 |
Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation.
Topics: Azacitidine; Decitabine; DNA Modification Methylases; Gene Expression Regulation; Humans; Lymphoma; Methylation; Neoplasm Metastasis; Restriction Mapping; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer.
Topics: Aged; Azacitidine; Carrier Proteins; Chromosome Deletion; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA, Neoplasm; Gene Expression; Heterozygote; Humans; Male; Middle Aged; Neoplasm Metastasis; Polymerase Chain Reaction; Prostatic Neoplasms; Sequence Analysis, DNA; Tumor Cells, Cultured | 1997 |
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.
Topics: Antigens, Neoplasm; Azacitidine; Clone Cells; Decitabine; Disease Progression; Eye Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Metastasis; Neoplasm Proteins; Tumor Cells, Cultured | 1997 |
Counter-selection for over-expressed human CD44s in primary tumors versus lung metastases in a mouse fibrosarcoma model.
Topics: 3T3 Cells; Animals; Antigens, CD; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Decitabine; Fibrosarcoma; Genes, ras; Humans; Hyaluronan Receptors; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Oncogene Proteins v-sis; Oncogenes; Retroviridae Proteins, Oncogenic; Transfection | 1997 |
Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Colonic Neoplasms; Decitabine; DNA Methylation; Gene Expression Regulation; HT29 Cells; Humans; Neoplasm Metastasis; S100 Calcium-Binding Protein A4; S100 Proteins; Transcriptional Activation; Tumor Cells, Cultured | 1998 |
Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Movement; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Monomeric GTP-Binding Proteins; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Promoter Regions, Genetic; Transcription Factors; Transfection; Tumor Cells, Cultured | 2001 |
Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences.
Topics: Amino Acid Motifs; Azacitidine; Base Sequence; Binding Sites; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Exons; gamma-Synuclein; Humans; Introns; Models, Genetic; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines.
Topics: Adenocarcinoma; Antigens, CD; Azacitidine; Base Sequence; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Kangai-1 Protein; Male; Membrane Glycoproteins; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Proto-Oncogene Proteins; Sulfites; Tumor Cells, Cultured | 2001 |
Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Azacitidine; Chi-Square Distribution; Colorectal Neoplasms; Decitabine; Female; Humans; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Lymphatic Metastasis; Male; Membrane Glycoproteins; Methylation; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Proteoglycans; RNA, Messenger; RNA, Neoplasm; Survival Analysis; Syndecan-1; Syndecans; Tumor Cells, Cultured | 2001 |
High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis.
Topics: Aged; Alleles; Antigens, CD; Azacitidine; Carcinoma, Squamous Cell; Chromosomes, Human, Pair 11; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; DNA, Neoplasm; Enzyme Inhibitors; Epithelium; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Kangai-1 Protein; Male; Membrane Glycoproteins; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.
Topics: Azacitidine; Chromatography, Thin Layer; Erythrocytes; Feces; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infusions, Parenteral; Injections, Intravenous; Leukemia; Leukocytes; Magnetic Resonance Spectroscopy; Neoplasm Metastasis; Nucleic Acids; Serum Albumin; Solvents; Sputum; Temperature; Time Factors; Urea | 1976 |
5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia.
Topics: Agranulocytosis; Azacitidine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Nausea; Neoplasm Metastasis; Vomiting | 1976 |
Phase II study of subcutaneously administered 5-azacytidine (NSC-102816) in patients with metastatic malignant melanoma.
Topics: Azacitidine; Bone Marrow; Dacarbazine; Drug Evaluation; Drug Resistance; Female; Humans; Injections, Subcutaneous; Male; Melanoma; Neoplasm Metastasis; Vomiting | 1978 |
Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Differentiation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Decitabine; DNA; Genes, ras; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger | 1991 |
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1985 |
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation | 1986 |
Metastatic phenotype of human prostate tumor cells in athymic nude mice: alteration by exposure to ethyl methanesulfonate and "reversion" by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Line; Ethyl Methanesulfonate; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Phenotype; Prostatic Neoplasms | 1986 |
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methylation; Mice; Neoplasm Metastasis | 1986 |
Changes in the tumorigenic and metastatic properties of tumor cells treated with quercetin or 5-azacytidine.
Topics: Animals; Azacitidine; Cell Line; DNA; Fibrosarcoma; Flavonoids; Methylation; Mice; Mice, Inbred C57BL; Mutagens; Neoplasm Metastasis; Neoplasm Transplantation; Phenotype; Quercetin | 1987 |
Selection of metastatic variants with identifiable karyotypic changes from a nonmetastatic murine tumor after treatment with 2'-deoxy-5-azacytidine or hydroxyurea: implications for the mechanisms of tumor progression.
Topics: Animals; Azacitidine; Cell Division; Clone Cells; Decitabine; DNA; Female; Hydroxyurea; Karyotyping; Mammary Neoplasms, Experimental; Mathematics; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Phenotype | 1987 |
Clonal variation in the impact of ethyl methanesulfonate and 5-azacytidine on the metastatic phenotype of human prostatic tumor cells in athymic nude mice.
Topics: Animals; Azacitidine; Clone Cells; Ethyl Methanesulfonate; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Prostatic Neoplasms; Tumor Cells, Cultured | 1988 |