azacitidine has been researched along with Melanoma in 112 studies
*Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (9.82) | 18.7374 |
| 1990's | 11 (9.82) | 18.2507 |
| 2000's | 41 (36.61) | 29.6817 |
| 2010's | 46 (41.07) | 24.3611 |
| 2020's | 3 (2.68) | 2.80 |
| Authors | Studies |
|---|---|
| Abbasi, MM; Beisler, JA; Driscoll, JS; Kelley, JA | 1 |
| Feige, U; Hamed, E; Hanft, KM; Hettmer, S; Kaiser, M; Krengel, S; Meiss, F; Niemeyer, C; Pietsch, T; Schneider, M; Würtemberger, J | 1 |
| Chen, DX; Chen, L; Jiang, J; Niu, HT; Wang, X; Xie, R; Yang, CH; Zhai, L; Zhang, J; Zhang, YJ | 1 |
| Amato, G; Anichini, A; Azab, M; Bock, C; Coral, S; Covre, A; Cutaia, O; Danielli, R; Di Giacomo, AM; Fazio, C; Finotello, F; Fridman, WH; Giannarelli, D; Lacroix, L; Lazzeri, A; Lowder, J; Maio, M; Miracco, C; Monterisi, S; Nemc, A; Oganesian, A; Petitprez, F; Rieder, D; Sautès-Fridman, C; Sigalotti, L; Trajanoski, Z; Valente, M | 1 |
| Bassermann, F; Dahl, S; Haas, T; Heidegger, S; Poeck, H; Wintges, A | 1 |
| Bosenberg, M; Micevic, G; Theodosakis, N | 1 |
| Hwang, JT; Jeong, JC; Kim, EJ; Lee, YK; Park, UH; Um, SJ | 1 |
| Nakagawa, H; Nobeyama, Y | 1 |
| Bowden, NA; Budden, T; van der Westhuizen, A | 1 |
| Held, G; Kaddu-Mulindwa, D; Kubuschok, B; Neumann, F; Pfreundschuh, M; Preuss, KD; Roemer, K; Widmann, T; Zwick, C | 1 |
| Bernasconi, MJ; Cogdill, AP; Gunda, V; Parangi, S; Wargo, JA | 1 |
| Bassett, RL; Desai, JR; Hwu, WJ; Ilagan, JL; Issa, JP; Jelinek, J; Papadopoulos, NE; Plimack, ER; Sharma, P; Vence, LM | 1 |
| Deutsch, J; Frees, M; Laux, D; Leon-Ferre, R; Milhem, M; Smith, BJ; Xia, C | 1 |
| Capobianco, E; Cinti, C; El Baroudi, M; La Sala, D | 1 |
| Asnaghi, L; Eberhart, CG; Enke, R; Handa, JT; Merbs, SL; Rajaii, F | 1 |
| Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J | 1 |
| Biondo, C; Catalano, T; Lentini, M; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Haraguchi, T; Itamoto, K; Mizuno, T; Mori, T; Nakagawa, T; Noguchi, S | 1 |
| Frøsig, TM | 1 |
| Licht, JD | 1 |
| Akman, B; Baylin, SB; Beckmann, MW; Budhu, S; Buhu, S; Chan, TA; Chiappinelli, KB; Cope, LM; Desrichard, A; Hein, A; Henke, C; Li, H; Makarov, V; Merghoub, T; Mergoub, T; Pardoll, DM; Rote, NS; Slamon, DJ; Snyder, A; Strick, R; Strissel, PL; Wolchok, JD; Zahnow, CA | 1 |
| Igase, M; Mizuno, T; Mori, T; Noguchi, S | 1 |
| Gasque Schoof, CR; Izzotti, A; Jasiulionis, MG; Vasques, Ldos R | 1 |
| Anaka, M; Behren, A; Cebon, J; Chueh, AC; Davalos-Salas, M; Jayachandran, A; Lo, PH; Molania, R; Prithviraj, P; Walkiewicz, M | 1 |
| Coulie, PG; da Silva, M; Debets, R; Kunert, A; Lamers, C; Sleijfer, S; van Brakel, M; van Steenbergen-Langeveld, S | 1 |
| Chen, H; Jin, X; Jin, Z; Kim, KY; Roh, MR; Zheng, Z | 1 |
| Bracci, L; Buccione, C; Businaro, L; D'Urso, MT; De Ninno, A; Gerardino, A; Lucarini, V; Macchia, D; Macchia, I; Mattei, F; Mattia, G; Mozetic, P; Parolini, I; Peschiaroli, F; Puglisi, R; Rainer, A; Rossi, A; Schiavoni, G; Sestili, P; Spada, M; Trombetta, M; Zanetti, C; Ziccheddu, G | 1 |
| Beninati, C; Catalano, T; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Chen, L; Gong, F; Guo, Y; Jin, J; Li, R; Ma, RZ; Niu, Y; Shi, X; Zhang, L; Zhang, X | 1 |
| Bonazzi, VF; Hayward, NK; Irwin, D | 1 |
| Furukawa, H; Hamada, J; Hata, S; Maeda, K; Moriuchi, T; Murai, T; Saito, A; Tada, M; Tsutsumida, A; Yamamoto, Y | 1 |
| Cornelius, LA; Feng, Y; Gao, L; Yuan, L; Zhao, H; Zheng, H | 1 |
| Ariyan, S; Bacchiocchi, A; Cheng, E; Deng, M; Enghild, JJ; Halaban, R; Kluger, Y; Kovacs, D; Krauthammer, M; Molinaro, A; Narayan, D; Pelizzola, M; Picardo, M; Sznol, M; Tran, N; Zhang, W | 1 |
| Ibrahim, SM; Kunz, M; Schultz, J; Vera, J | 1 |
| Fan, J; Niles, RM; Zhu, GZ | 1 |
| Bhat, KM; Devi, S; Maddodi, N; Setaluri, V; Zhang, SC | 1 |
| Denner, J; Fiebig, U; Kurth, R; Stengel, S | 1 |
| Altomonte, M; Calabrò, L; Colizzi, F; Coral, S; Covre, A; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Nicolay, HJ; Sigalotti, L | 1 |
| Halaban, R; Krauthammer, M; Ma, S; Rubinstein, JC; Tran, N | 1 |
| Collnot, EM; Denzer, N; Essa, S; Klein, R; Mahlknecht, U; Reichrath, J; Tilgen, W | 1 |
| Dar, AA; de Semir, D; Federman, S; Kashani-Sabet, M; Majid, S; Nosrati, M | 1 |
| Bazhin, AV; De Smet, C; Golovastova, MO; Philippov, PP; Schmidt, J | 1 |
| Certa, U; Foser, S; Scott, R; Siegrist, F | 1 |
| Califano, JA; Mithani, SK; Smith, IM | 1 |
| Aurelian, L; Lee, KS; Li, B; Liu, J; Smith, CC | 1 |
| Chen, DW; Liu, QY; Wang, HZ; Xie, LP; Zhang, RQ | 1 |
| Essa, S; Mahlknecht, U; Montenarh, M; Reichrath, J; Reichrath, S; Vogt, T | 1 |
| Cheung, KH; Holford, ME; Krauthammer, M; McCusker, JP | 1 |
| Dai, X; Wang, Y; Zhang, F | 1 |
| Howell, PM; Liu, S; Riker, AI | 1 |
| Bernardo, V; da Silva, DC; de Souza, CF; Jasiulionis, MG; Lopes, JD; Mai, S; Monteiro, AC; Silva, AG; Xander, P | 1 |
| Colizzi, F; Coral, S; Covre, A; Danielli, R; Fratta, E; Maio, M; Nicolay, HJ; Parisi, G; Sigalotti, L; Taverna, P | 1 |
| Beumer, JH; Buch, SC; Christner, S; Egorin, MJ; Kirkwood, JM; Lin, Y; Moschos, S; Tarhini, AA; Tawbi, HA | 1 |
| Borden, EC; Fruehauf, JP; Haney, R; Jacobs, BS; Lindner, DJ; Tuthill, R; Wu, Y | 1 |
| Bezrookove, V; Dar, AA; de Semir, D; Kashani-Sabet, M; Majid, S; Miller, JR; Nosrati, M; Rittsteuer, C; Sagebiel, R; Tong, S | 1 |
| Bert, T; Gangsauge, S; Lubomierski, N; Münch, K; Prasnikar, N; Printz, H; Robbel, C; Simon, B | 1 |
| Altomonte, M; Colizzi, F; Coral, S; Fonsatti, E; Maio, M; Sigalotti, L | 1 |
| Frants, RR; Gruis, NA; Hurks, MHMH; Jager, MJ; Krijgsman, E; Ksander, BR; Pavey, S; Tensen, CP; van der Velden, PA; Willemze, R; Zuidervaart, W | 1 |
| Gołab, J; Jakóbisiak, M; Kamiński, R; Kozar, K; Lasek, W; Machaj, E; Mackiewicz, A; Ołdak, T; Switaj, T; Wysocki, PJ | 1 |
| Guan, X; Koganehira, Y; Oguchi, M; Sagara, J; Saida, T; Taniguchi, S; Yokoyama, T | 1 |
| Heng, HH; Iwata, J; Liang, SB; Ohtsuki, Y; Sonobe, H; Takeuchi, T; Ye, CJ | 1 |
| Grossman, D; Hanks, AN; Jones, DA; Karpf, AR; Lasek, AW; Ririe, TO | 1 |
| Blaschke, B; Knobbe, CB; Reifenberger, G; Reifenberger, J; Ruzicka, T; Schulte, KW; Sterzinger, AA | 1 |
| Akasaka, T; Maesawa, C; Masuda, T; Wada, K | 1 |
| Golab, J; Grzela, T; Jakobisiak, M; Kaminski, R; Koronkiewicz, M; Kozar, K; Niderla, J; Skierski, JS; Wilczynski, G | 1 |
| Altomonte, M; Colizzi, F; Coral, S; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Sigalotti, L; Tanzarella, S; Traversari, C | 1 |
| Furuta, J; Kaneda, A; Otsuka, F; Sugimura, T; Umebayashi, Y; Ushijima, T | 1 |
| Hoon, DS; Huang, S; Kim, J; Koyanagi, K; Mori, T; Takeuchi, H; Umetani, N; Yamano, T | 1 |
| Chang, CC; Ferrone, S; Lin, AF; Yan, WH | 1 |
| Ferrone, S; Kageshita, T; Karpf, AR; Luo, W; Wakasugi, S; Wang, X | 1 |
| Jager, M; Ono, SJ; Radosevich, M | 1 |
| Hoon, DS; Kitago, M; Martinez, SR; Mori, T; Morton, DL; Nguyen, SL; O'Day, SJ; Tanemura, A; Tran, AN; Umetani, N; Wang, HJ | 1 |
| Dressman, HK; Gollob, JA; Issa, JP; Jelinek, J; Moran, K; Peterson, BL; Richmond, T; Sciambi, CJ; Thoreson, M | 1 |
| Bosenberg, M; Bradbury, CM; Curley, DP; Duraisamy, S; Hobbs, C; Muthusamy, V; Nelson, B | 1 |
| Bandle, R; Clair, T; Koh, E; Roberts, DD; Stracke, ML | 1 |
| Bazhin, AV; Eichmüller, SB; Schadendorf, D; Schnölzer, M; Wiedemann, N | 1 |
| Coral, S; Covre, A; Maio, M; Natali, PG; Nicolay, HJ; Sigalotti, L | 1 |
| Furuta, J; Kikuchi, K; Miyagi, Y; Nakagawa, H; Nakanishi, Y; Nobeyama, Y; Okochi-Takada, E; Ushijima, T; Yamamoto, A | 1 |
| Altomonte, M; Calabrò, L; Colizzi, F; Fonsatti, E; Guidoboni, M; Maio, M; Marincola, FM; Nicolay, HJ; Pezzani, L; Sigalotti, L | 1 |
| Bae, SI; Borden, EC; Cheriyath, V; Jacobs, BS; Reu, FJ | 1 |
| Gollob, JA; Sciambi, CJ | 1 |
| Brasseur, F; De Plaen, E; De Smet, C; Kholmanskikh, O; Loriot, A | 1 |
| Coppock, DL; Straus, DS | 1 |
| Herlyn, M; Johnson, B; Lassam, N; Rosenberg, SA; Salgaller, M; Samid, D; Treisman, J; Weber, J | 1 |
| Creagan, ET; Hartmann, LC; Loprinzi, CL; Schaid, DJ | 1 |
| Boon, T; Brasseur, F; De Backer, O; De Smet, C; Faraoni, I; Lurquin, C | 1 |
| Carrel, S; Cerottini, JC; Rimoldi, D; Schreyer, M; Spagnoli, G | 1 |
| Boon, T; De Plaen, E; De Smet, C; Naerhuyzen, B; Szikora, JP | 1 |
| Chen, PW; Ksander, BR; Murray, TG; Reddy, R; Salgaller, ML; Uno, T | 1 |
| Altomonte, M; Cattarossi, I; Cattelan, A; Coral, S; Gasparollo, A; Maio, M; Sigalotti, L; Visintin, A | 1 |
| Arden, KC; Boon, T; Boretti, M; Brasseur, F; Chomez, P; Czekay, S; De Backer, O; De Plaen, E; De Smet, C; Van den Eynde, B; van der Bruggen, P; Vantomme, V; Viars, CS | 1 |
| Adema, GJ; de Bruijn, DR; de Vries, TJ; dos Santos, NR; Kater-Baats, E; Ruiter, DJ; Schreurs, MW; Torensma, R; van Kessel, AG; van Muijen, GN | 1 |
| Chen, GA; Fischette, MR; Guo, ZS; Hong, JA; Nguyen, DM; Ohnmacht, GA; Schrump, DS; Weiser, TS | 1 |
| Altomonte, M; Cattarossi, I; Ciullo, M; Coral, S; Gasparollo, A; Guardiola, J; Maio, M; Prisco, A; Sigalotti, L | 1 |
| Christmann, M; Kaina, B; Lage, H; Pick, M; Schadendorf, D | 1 |
| Bergman, W; Frants, RR; Gruis, NA; Hurks, H; Jager, MJ; Metzelaar-Blok, JA; Monique, H; van der Velden, PA | 1 |
| Gorelik, E; Huang, X; Li, M; Orucevic, A | 1 |
| Garrido, F; Lionello, I; Mendez, R; Ruiz-Cabello, F; Serrano, A; Tanzarella, S; Traversari, C | 1 |
| den Hollander, AI; Ruiter, DJ; van Kraats, AA; van Muijen, GN; Weidle, UH; Zendman, AJ | 1 |
| Biesta, P; Quinten, E; van den Elsen, PJ; van der Stoep, N | 1 |
| Bellet, RE; Berd, D; Catalano, RB; Mastrangelo, MJ | 1 |
| Bellet, RE; Berd, D; Danna, V; Mastrangelo, MJ | 1 |
| Abbruzzese, JL; Frost, P | 1 |
| Grant, JH; Kudlow, JE; Meluch, AA; Paterson, AJ; Shin, TH | 1 |
| Parsons, PG; Takahashi, H | 1 |
| Gorelik, E; Herberman, RB; Overton, R; Peppoloni, S | 1 |
| Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL | 1 |
| Everett, CA; Hart, IR; Ormerod, EJ | 1 |
| Everett, CA; Finch, M; Hart, IR; Ormerod, EJ | 1 |
| Bernheim, J; Buyssens, N; Cortvrindt, R; Roobol, K | 1 |
| Abele, R; Bruntsch, U; Clavel, M; Dodion, P; Gundersen, S; Pinedo, HM; Renard, J; Smyth, J; van Glabbeke, M | 1 |
| Barbieri, R; Fisher, PB; Gambari, R; Giacomini, P; Natali, PG; Piva, R; Tecce, R | 1 |
1 review(s) available for azacitidine and Melanoma
| Article | Year |
|---|---|
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.
Topics: Azacitidine; Biomarkers, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Melanoma; MicroRNAs; Prognosis | 2017 |
7 trial(s) available for azacitidine and Melanoma
| Article | Year |
|---|---|
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; CD8-Positive T-Lymphocytes; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Ipilimumab; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Patient Safety; Programmed Cell Death 1 Receptor; Survival Rate; Treatment Outcome | 2019 |
A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA Methylation; Female; Humans; Interferon alpha-2; Interferon-alpha; Leukocyte Count; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neutropenia; Polyethylene Glycols; Recombinant Proteins; T-Lymphocyte Subsets | 2014 |
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epigenomics; Eye Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Panobinostat; Skin Neoplasms; Temozolomide; Treatment Outcome | 2014 |
Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; Disease-Free Survival; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Skin Neoplasms; Temozolomide | 2013 |
Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Renal Cell; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Fetal Hemoglobin; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Injections, Intravenous; Injections, Subcutaneous; Interleukin-2; Kidney Neoplasms; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Predictive Value of Tests; Treatment Outcome | 2006 |
A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biopsy; Chest Pain; Female; Humans; Immunologic Factors; Infusions, Intravenous; Male; Melanoma; Middle Aged; Nausea; Remission Induction; Risk Factors; Severity of Illness Index; Survival Rate; Vomiting | 1993 |
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Clinical Trials as Topic; Decitabine; Female; Hematologic Diseases; Humans; Male; Melanoma; Middle Aged; Neoplasms | 1987 |
104 other study(ies) available for azacitidine and Melanoma
| Article | Year |
|---|---|
Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Hydrolysis; Leukemia L1210; Leukemia, Experimental; Melanoma; Mice; Neoplasms, Experimental | 1977 |
Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.
Topics: Azacitidine; Child, Preschool; GTP Phosphohydrolases; Humans; Male; Melanoma; Membrane Proteins; Meningeal Neoplasms; Mitogen-Activated Protein Kinase Kinases; Mutation; Nevus, Pigmented; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Skin Neoplasms | 2022 |
5‑Aza‑dC suppresses melanoma progression by inhibiting GAS5 hypermethylation.
Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mice; Mice, Nude; RNA, Long Noncoding | 2022 |
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
Topics: Animals; Azacitidine; Chemoradiotherapy; Disease Models, Animal; Drug Synergism; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Signal Transduction; Treatment Outcome | 2021 |
Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells.
Topics: Antigens, Neoplasm; Azacitidine; Binding Sites; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Kruppel-Like Transcription Factors; Melanoma; Promoter Regions, Genetic; Protein Binding; RNA Interference; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Transfection; Up-Regulation | 2017 |
Silencing of metallothionein 1A gene in melanoma.
Topics: 5' Untranslated Regions; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Child; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanocytes; Melanoma; Metallothionein; Middle Aged; Nevus, Pigmented; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Young Adult | 2017 |
Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carboplatin; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Damage; DNA Methylation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Promoter Regions, Genetic | 2018 |
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Topics: Antigen-Presenting Cells; Antigens, Neoplasm; Azacitidine; B-Lymphocytes; Cancer Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Melanoma; Neoplasms; RNA, Messenger; Telomerase; Telomere; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat | 2013 |
Potential role of 5-aza-2'-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression; Humans; Immunotherapy; Indoles; MAP Kinase Signaling System; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Sulfonamides; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2013 |
Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Female; Gene Regulatory Networks; Genes, Neoplasm; Humans; Melanoma; Signal Transduction; Transcription, Genetic; Up-Regulation | 2014 |
The demethylating agent 5-Aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colony-Forming Units Assay; Decitabine; DNA Modification Methylases; DNA, Neoplasm; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Neoplasms, Experimental; Skin Neoplasms; Uveal Neoplasms | 2014 |
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin | 2014 |
Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma.
Topics: Adult; Azacitidine; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Humans; Melanoma; Promoter Regions, Genetic; Tumor Suppressor Protein p14ARF; Uveal Neoplasms | 2015 |
DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cells, Cultured; DNA Methylation; Dog Diseases; Dogs; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Melanocytes; Melanoma; MicroRNAs; Mouth Neoplasms | 2015 |
Elucidating the immunological effects of 5-azacytidine treatment in patients with myelodysplastic syndrome and identifying new conditional ligands and T-cell epitopes of relevance in melanoma.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Epitopes, T-Lymphocyte; HLA-A Antigens; Humans; Immunologic Factors; Leukocytes, Mononuclear; Ligands; Melanoma; Myelodysplastic Syndromes; Nodal Protein; T-Lymphocytes; White People | 2015 |
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Colorectal Neoplasms; DNA Methylation; Female; Humans; Interferon Type I; Melanoma | 2015 |
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Topics: Animals; Azacitidine; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Endogenous Retroviruses; Female; Humans; Immunotherapy; Interferon Type I; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; RNA, Double-Stranded | 2015 |
A novel apoptosis-inducing mechanism of 5-aza-2'-deoxycitidine in melanoma cells: Demethylation of TNF-α and activation of FOXO1.
Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; DNA Methylation; Dogs; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Prognosis; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Silencing; Melanocytes; Melanoma; Mice; MicroRNAs; Promoter Regions, Genetic | 2015 |
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Transketolase; Up-Regulation | 2016 |
MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses.
Topics: Antigens, Neoplasm; Azacitidine; B7-1 Antigen; B7-2 Antigen; B7-H1 Antigen; Cell Line, Tumor; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Melanoma; Neoplasm Proteins; Receptors, Antigen, T-Cell; T-Lymphocytes; Valproic Acid | 2016 |
Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Child; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2016 |
Combining Type I Interferons and 5-Aza-2'-Deoxycitidine to Improve Anti-Tumor Response against Melanoma.
Topics: Analysis of Variance; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Interferon Type I; Melanoma; Mice; Mice, Inbred C57BL; Skin Neoplasms; Statistics, Nonparametric | 2017 |
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Melanoma; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Skin Neoplasms; Time Factors; Treatment Outcome; Up-Regulation; Uveal Neoplasms | 2017 |
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Dioxygenases; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Demethylation; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Small Interfering; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2017 |
Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.
Topics: Azacitidine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; Esophageal Neoplasms; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glioma; Heat-Shock Proteins; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Proteins; Microfilament Proteins; Neuropeptides; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
PAX4 has the potential to function as a tumor suppressor in human melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Replication; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Paired Box Transcription Factors; RNA, Messenger; Skin Neoplasms; Time Factors; Transfection; Tumor Suppressor Proteins | 2008 |
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Survival; Decitabine; DNA Methylation; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesions; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Melanoma; Phosphorylation; Promoter Regions, Genetic; rap1 GTP-Binding Proteins; Transfection | 2009 |
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications.
Topics: Apoptosis; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Computational Biology; Decitabine; DNA Damage; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Melanoma | 2009 |
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.
Topics: 14-3-3 Proteins; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cellular Senescence; CpG Islands; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Exonucleases; Exoribonucleases; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Neoplasm Metastasis; Neoplasm Proteins; Phenylbutyrates; RNA, Messenger | 2009 |
Expression and function of CD9 in melanoma cells.
Topics: Animals; Antigens, CD; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Infant, Newborn; Melanocytes; Melanoma; Membrane Glycoproteins; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetraspanin 29; Transfection | 2010 |
Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1.
Topics: Amino Acid Substitution; Animals; Azacitidine; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Cell Line, Tumor; CpG Islands; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; MAP Kinase Signaling System; Melanoma; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mutant Proteins; Neurons; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Response Elements; Transcription Factor HES-1; Transcription, Genetic | 2010 |
Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Endogenous Retroviruses; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Gene Silencing; Humans; Melanoma; Promoter Regions, Genetic; RNA Splicing; Sequence Analysis, RNA; Sulfites; Terminal Repeat Sequences; Viral Envelope Proteins | 2010 |
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Clone Cells; Cloning, Molecular; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Inheritance Patterns; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Genome, Human; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Tumor Suppressor Proteins; Up-Regulation | 2010 |
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; MicroRNAs; Receptors, Calcitriol; Signal Transduction; Skin Neoplasms; Time Factors; Vitamin D | 2010 |
Functional modulation of IGF-binding protein-3 expression in melanoma.
Topics: Apoptosis; Azacitidine; Base Sequence; Caspase 3; Cell Division; Cell Line, Tumor; Cell Survival; Chromatin; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Melanoma; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms | 2010 |
Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Exons; Gene Expression Regulation, Neoplastic; Humans; Lung; Melanoma; Neoplasms; Promoter Regions, Genetic; Recoverin; Skin; Small Cell Lung Carcinoma | 2010 |
Interferon-alpha induces reversible DNA demethylation of the interferon-induced transmembrane protein-3 core promoter in human melanoma cells.
Topics: Azacitidine; Biomarkers, Pharmacological; Cell Growth Processes; Cell Line, Tumor; Chemotactic Factors; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Melanoma; Membrane Proteins; Promoter Regions, Genetic; RNA-Binding Proteins; S100 Proteins; Transforming Growth Factor beta; Transgenes | 2011 |
Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Proliferation; Comparative Genomic Hybridization; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomics; Humans; Male; Melanoma; Middle Aged; Oligonucleotide Array Sequence Analysis; Skin Neoplasms; Transfection | 2011 |
The Levels of H11/HspB8 DNA methylation in human melanoma tissues and xenografts are a critical molecular marker for 5-Aza-2'-deoxycytidine therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle; Decitabine; DNA Methylation; Female; Heat-Shock Proteins; Humans; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Molecular Chaperones; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays | 2011 |
Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Division; Cell Proliferation; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; G2 Phase; Melanoma; Mice; Tumor Cells, Cultured | 2011 |
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cell Proliferation; Cells, Cultured; Epigenomics; Humans; Melanocytes; Melanoma; MicroRNAs; Real-Time Polymerase Chain Reaction; Receptors, Calcitriol; RNA, Messenger; Skin Neoplasms; Vitamin D | 2012 |
A semantic web framework to integrate cancer omics data with biological knowledge.
Topics: Azacitidine; Database Management Systems; Decitabine; Drug Resistance, Neoplasm; Epigenomics; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Humans; Internet; Melanoma; Semantics; Transcription Factors; Translational Research, Biomedical | 2012 |
5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cholesterol; Decitabine; Dipeptidyl Peptidase 4; DNA Methylation; Epigenesis, Genetic; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Neoplastic; Geranyltranstransferase; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Mass Spectrometry; Melanoma; Proteomics; RNA, Small Interfering | 2012 |
Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; MicroRNAs; Oligonucleotide Array Sequence Analysis; Skin; Skin Neoplasms; Up-Regulation | 2013 |
Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.
Topics: Animals; Azacitidine; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Hydroxamic Acids; Karyotyping; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Phenotype; Risk; Skin Neoplasms | 2012 |
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Cytotoxicity, Immunologic; DNA Methylation; Humans; Immunomodulation; Immunophenotyping; Immunotherapy; Melanoma; Neoplasms | 2013 |
Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis.
Topics: Animals; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Methylation; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2013 |
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatin Immunoprecipitation; DNA Methylation; Epithelial-Mesenchymal Transition; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Luciferases; Melanoma; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Point Mutation; Proto-Oncogene Proteins c-mdm2; Real-Time Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Transplantation, Heterologous; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
Expression spectrum and methylation-dependent regulation of melanoma antigen-encoding gene family members in pancreatic cancer cells.
Topics: Adult; Aged; Antigens, Neoplasm; Azacitidine; Culture Techniques; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression; Gene Expression Regulation; Humans; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2002 |
Methylation-regulated expression of HLA class I antigens in melanoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Genes, MHC Class I; HLA Antigens; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; Tumor Cells, Cultured; Up-Regulation | 2003 |
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.
Topics: Azacitidine; Biomarkers, Tumor; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Probes; Down-Regulation; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Liver Neoplasms; Melanoma; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Uveal Neoplasms | 2003 |
Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; CD4 Antigens; CD8 Antigens; Cell Line, Tumor; Cell Survival; Decitabine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Immunotherapy; Interferon-gamma; Interleukin-12; Interleukin-4; Lectins, C-Type; Lymph Nodes; Lymphocytes; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, SCID; Models, Genetic; Neutrophils; NK Cell Lectin-Like Receptor Subfamily B; Protein Biosynthesis; Proteins; Time Factors | 2003 |
ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma.
Topics: Apoptosis; Azacitidine; Blotting, Western; CARD Signaling Adaptor Proteins; Caspase 1; CpG Islands; Cytoskeletal Proteins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; DNA, Neoplasm; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Nevus, Pigmented; Polymerase Chain Reaction; Proteins; Skin Neoplasms; Sulfites; Tumor Cells, Cultured | 2003 |
Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.
Topics: Actins; Amino Acid Sequence; Azacitidine; Blotting, Northern; Blotting, Western; Cloning, Molecular; Decitabine; DNA, Complementary; Down-Regulation; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Melanoma; Microfilament Proteins; Molecular Sequence Data; Neoplasm Proteins; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases; Yeasts | 2003 |
Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Epithelial Cells; Gene Expression Regulation; Humans; Melanocytes; Melanoma; Melanoma-Specific Antigens; Multigene Family; Neoplasm Proteins; Transcriptional Activation | 2004 |
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2004 |
Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Serpins | 2004 |
Demethylating agent 5-aza-2'-deoxycytidine enhances expression of TNFRI and promotes TNF-mediated apoptosis in vitro and in vivo.
Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Separation; CpG Islands; Decitabine; DNA Fragmentation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Proteins; Ribonucleases; RNA; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; HLA-B Antigens; Humans; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms | 2004 |
Silencing of the thrombomodulin gene in human malignant melanoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanocytes; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms; Thrombomodulin | 2005 |
Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2005 |
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Calreticulin; Cell Line, Tumor; Choriocarcinoma; Decitabine; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Melanoma; Methylation; Promoter Regions, Genetic; Transcription, Genetic | 2005 |
Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.
Topics: Antigens, Neoplasm; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Melanoma; Promoter Regions, Genetic; Tumor Cells, Cultured | 2006 |
Inhibition of MHC class II gene expression in uveal melanoma cells is due to methylation of the CIITA gene or an upstream activator.
Topics: Azacitidine; Base Sequence; Blotting, Southern; Cell Line, Tumor; DNA Methylation; Eye; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; HeLa Cells; Humans; Interferon-gamma; Melanoma; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Uveal Neoplasms | 2007 |
Estrogen receptor-alpha methylation predicts melanoma progression.
Topics: Age Factors; Azacitidine; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Sex Factors | 2006 |
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Topics: Animals; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Syk Kinase; Transfection; Transplantation, Heterologous; Tumor Suppressor Proteins | 2006 |
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Hydroxamic Acids; Lysophospholipids; Melanoma; Nerve Tissue Proteins; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; RNA-Binding Proteins; RNA, Messenger; Sphingosine | 2007 |
Expression of GAGE family proteins in malignant melanoma.
Topics: Antigens, Neoplasm; Autoantibodies; Azacitidine; Cell Line, Tumor; Humans; Hydroxamic Acids; Immunohistochemistry; Melanoma; Neoplasm Proteins; Recombinant Proteins; Skin Neoplasms | 2007 |
5-AZA-2'-deoxycytidine in cancer immunotherapy: a mouse to man story.
Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Humans; Immunotherapy, Adoptive; Melanoma; Mice; Xenograft Model Antitumor Assays | 2007 |
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.
Topics: Azacitidine; Cell Line, Tumor; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation; Gene Silencing; Glycoproteins; Humans; Immunohistochemistry; Melanoma; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Ultraviolet Rays | 2007 |
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; gp100 Melanoma Antigen; Histocompatibility Antigens Class I; Humans; Immunotherapy; Interferon-gamma; Melanoma; Membrane Glycoproteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; T-Lymphocytes, Cytotoxic; Up-Regulation | 2007 |
Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL.
Topics: Apoptosis; Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Interferons; Melanoma; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2008 |
Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Chemotactic Factors; Decitabine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Interferon-gamma; Melanoma; S100 Proteins; Tumor Cells, Cultured; Uveal Neoplasms | 2007 |
Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.
Topics: Antigens, Neoplasm; Azacitidine; Blotting, Western; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Transfection; Tumor Cells, Cultured | 2008 |
Growth control variant cell line having increased serum requirement and decreased response to platelet-derived growth factor: reversion by 5-azacytidine.
Topics: Animals; Azacitidine; Blood; Cell Division; Cell Line; Clone Cells; DNA; Fibroblasts; Genetic Variation; Hybrid Cells; Insulin; Melanoma; Mice; Platelet-Derived Growth Factor | 1984 |
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Cell Line; Cytotoxicity, Immunologic; Decitabine; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Lymphocytes; Lymphocytes, Tumor-Infiltrating; Melanocytes; Melanoma; Melanoma-Specific Antigens; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured | 1994 |
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; Cross Reactions; Decitabine; Immunohistochemistry; Melanoma; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Recombinant Proteins; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Alternative promoters of gene MAGE4a.
Topics: Alternative Splicing; Amino Acid Sequence; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cloning, Molecular; Decitabine; DNA-Binding Proteins; DNA, Neoplasm; Exons; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Placenta; Promoter Regions, Genetic; Restriction Mapping; Rhabdomyosarcoma; RNA, Messenger; Sequence Analysis, DNA; Testis; Tumor Cells, Cultured | 1997 |
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.
Topics: Antigens, Neoplasm; Azacitidine; Clone Cells; Decitabine; Disease Progression; Eye Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Metastasis; Neoplasm Proteins; Tumor Cells, Cultured | 1997 |
Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR).
Topics: Alleles; Antigens, Neoplasm; Azacitidine; Blotting, Western; CD58 Antigens; Decitabine; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Intercellular Adhesion Molecule-1; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured; Up-Regulation | 1999 |
Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.
Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Chromosome Mapping; Cloning, Molecular; COS Cells; Decitabine; Exons; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Male; Melanoma; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Neoplasms; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Testis; Transcriptional Activation; Transfection; Tumor Cells, Cultured; X Chromosome | 1999 |
Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.
Topics: Adult; Antibodies, Monoclonal; Antibody Specificity; Azacitidine; Caco-2 Cells; Cell Nucleus; Child; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunohistochemistry; K562 Cells; Male; Melanoma; Microscopy, Fluorescence; Neoplasm Proteins; Recombinant Fusion Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sequence Deletion; Testis; Tumor Cells, Cultured | 2000 |
Induction of MAGE-3 expression in lung and esophageal cancer cells.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antigens, Neoplasm; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Depsipeptides; DNA Modification Methylases; Enzyme Inhibitors; Esophageal Neoplasms; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lung Neoplasms; Melanoma; Neoplasm Proteins; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; DNA, Complementary; Down-Regulation; Flow Cytometry; HLA-A Antigens; HLA-B Antigens; Humans; Interferon-gamma; Leukocytes, Mononuclear; Melanoma; Molecular Sequence Data; Neoplasms; Phenotype; Recombinant Proteins; Ribonucleases; RNA, Messenger; Sequence Homology, Nucleic Acid; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2001 |
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
Topics: Antineoplastic Agents; Azacitidine; Blotting, Southern; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Gene Amplification; Gene Expression; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Tumor Cells, Cultured | 2001 |
Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Uveal Neoplasms | 2001 |
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes.
Topics: Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, MHC Class I; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melanoma; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tumor Cells, Cultured; Up-Regulation | 2000 |
Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epitopes, T-Lymphocyte; Genes, MHC Class I; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2001 |
Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis.
Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Blotting, Northern; Chromosome Mapping; Cloning, Molecular; Decitabine; Disease Progression; DNA Modification Methylases; DNA Primers; DNA, Complementary; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testis; Transfection; Tumor Cells, Cultured | 2002 |
Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines.
Topics: Azacitidine; Burkitt Lymphoma; Carcinoma; Cell Differentiation; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, MHC Class II; Genes, Reporter; HLA-DR Antigens; Humans; Interferon-gamma; Melanoma; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Signal Transduction; Trans-Activators; Transfection; Tumor Cells, Cultured | 2002 |
Phase II study of subcutaneously administered 5-azacytidine (NSC-102816) in patients with metastatic malignant melanoma.
Topics: Azacitidine; Bone Marrow; Dacarbazine; Drug Evaluation; Drug Resistance; Female; Humans; Injections, Subcutaneous; Male; Melanoma; Neoplasm Metastasis; Vomiting | 1978 |
Evaluation of a "nude" mouse-human tumor panel as a predictive secondary screen for cancer chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carmustine; Dacarbazine; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance; Female; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms, Experimental | 1979 |
Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cisplatin; Decitabine; DNA, Neoplasm; Drug Resistance; Drug Synergism; Humans; Melanoma; Methylation; Mice; Sensitivity and Specificity; Tubercidin; Tumor Cells, Cultured | 1992 |
5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.
Topics: Azacitidine; Base Sequence; DNA; Gene Expression Regulation; Humans; Kinetics; Melanoma; Methylation; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression.
Topics: Antigens, Neoplasm; Azacitidine; Butyrates; Butyric Acid; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Dimethyl Sulfoxide; Dimethylformamide; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Melanins; Melanoma; Microscopy, Electron; Monophenol Monooxygenase; Organelles; Phenotype | 1990 |
Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N'-nitronitrosoguanidine.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cross Reactions; Female; H-2 Antigens; Histocompatibility Antigens; Major Histocompatibility Complex; Melanoma; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 1985 |
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1985 |
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation | 1986 |
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methylation; Mice; Neoplasm Metastasis | 1986 |
5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cells, Cultured; Cytidine; Decitabine; Drug Resistance; Melanoma; Mice; Mutation; Uridine | 1987 |
Regulation of the expression of class II genes of the human major histocompatibility complex in tumor cells.
Topics: Azacitidine; B-Lymphocytes; DNA, Neoplasm; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Interferons; Leukemia, Erythroblastic, Acute; Major Histocompatibility Complex; Melanoma; Methylation; Recombinant Proteins; Tumor Cells, Cultured | 1987 |