azacitidine and Melanoma

azacitidine has been researched along with Melanoma in 112 studies

*Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) [MeSH]

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-199011 (9.82)18.7374
1990's11 (9.82)18.2507
2000's41 (36.61)29.6817
2010's46 (41.07)24.3611
2020's3 (2.68)2.80

Authors

AuthorsStudies
Abbasi, MM; Beisler, JA; Driscoll, JS; Kelley, JA1
Feige, U; Hamed, E; Hanft, KM; Hettmer, S; Kaiser, M; Krengel, S; Meiss, F; Niemeyer, C; Pietsch, T; Schneider, M; Würtemberger, J1
Chen, DX; Chen, L; Jiang, J; Niu, HT; Wang, X; Xie, R; Yang, CH; Zhai, L; Zhang, J; Zhang, YJ1
Amato, G; Anichini, A; Azab, M; Bock, C; Coral, S; Covre, A; Cutaia, O; Danielli, R; Di Giacomo, AM; Fazio, C; Finotello, F; Fridman, WH; Giannarelli, D; Lacroix, L; Lazzeri, A; Lowder, J; Maio, M; Miracco, C; Monterisi, S; Nemc, A; Oganesian, A; Petitprez, F; Rieder, D; Sautès-Fridman, C; Sigalotti, L; Trajanoski, Z; Valente, M1
Bassermann, F; Dahl, S; Haas, T; Heidegger, S; Poeck, H; Wintges, A1
Bosenberg, M; Micevic, G; Theodosakis, N1
Hwang, JT; Jeong, JC; Kim, EJ; Lee, YK; Park, UH; Um, SJ1
Nakagawa, H; Nobeyama, Y1
Bowden, NA; Budden, T; van der Westhuizen, A1
Held, G; Kaddu-Mulindwa, D; Kubuschok, B; Neumann, F; Pfreundschuh, M; Preuss, KD; Roemer, K; Widmann, T; Zwick, C1
Bernasconi, MJ; Cogdill, AP; Gunda, V; Parangi, S; Wargo, JA1
Bassett, RL; Desai, JR; Hwu, WJ; Ilagan, JL; Issa, JP; Jelinek, J; Papadopoulos, NE; Plimack, ER; Sharma, P; Vence, LM1
Deutsch, J; Frees, M; Laux, D; Leon-Ferre, R; Milhem, M; Smith, BJ; Xia, C1
Capobianco, E; Cinti, C; El Baroudi, M; La Sala, D1
Asnaghi, L; Eberhart, CG; Enke, R; Handa, JT; Merbs, SL; Rajaii, F1
Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J1
Biondo, C; Catalano, T; Lentini, M; Teti, D; Venza, I; Venza, M; Visalli, M1
Haraguchi, T; Itamoto, K; Mizuno, T; Mori, T; Nakagawa, T; Noguchi, S1
Frøsig, TM1
Licht, JD1
Akman, B; Baylin, SB; Beckmann, MW; Budhu, S; Buhu, S; Chan, TA; Chiappinelli, KB; Cope, LM; Desrichard, A; Hein, A; Henke, C; Li, H; Makarov, V; Merghoub, T; Mergoub, T; Pardoll, DM; Rote, NS; Slamon, DJ; Snyder, A; Strick, R; Strissel, PL; Wolchok, JD; Zahnow, CA1
Igase, M; Mizuno, T; Mori, T; Noguchi, S1
Gasque Schoof, CR; Izzotti, A; Jasiulionis, MG; Vasques, Ldos R1
Anaka, M; Behren, A; Cebon, J; Chueh, AC; Davalos-Salas, M; Jayachandran, A; Lo, PH; Molania, R; Prithviraj, P; Walkiewicz, M1
Coulie, PG; da Silva, M; Debets, R; Kunert, A; Lamers, C; Sleijfer, S; van Brakel, M; van Steenbergen-Langeveld, S1
Chen, H; Jin, X; Jin, Z; Kim, KY; Roh, MR; Zheng, Z1
Bracci, L; Buccione, C; Businaro, L; D'Urso, MT; De Ninno, A; Gerardino, A; Lucarini, V; Macchia, D; Macchia, I; Mattei, F; Mattia, G; Mozetic, P; Parolini, I; Peschiaroli, F; Puglisi, R; Rainer, A; Rossi, A; Schiavoni, G; Sestili, P; Spada, M; Trombetta, M; Zanetti, C; Ziccheddu, G1
Beninati, C; Catalano, T; Teti, D; Venza, I; Venza, M; Visalli, M1
Chen, L; Gong, F; Guo, Y; Jin, J; Li, R; Ma, RZ; Niu, Y; Shi, X; Zhang, L; Zhang, X1
Bonazzi, VF; Hayward, NK; Irwin, D1
Furukawa, H; Hamada, J; Hata, S; Maeda, K; Moriuchi, T; Murai, T; Saito, A; Tada, M; Tsutsumida, A; Yamamoto, Y1
Cornelius, LA; Feng, Y; Gao, L; Yuan, L; Zhao, H; Zheng, H1
Ariyan, S; Bacchiocchi, A; Cheng, E; Deng, M; Enghild, JJ; Halaban, R; Kluger, Y; Kovacs, D; Krauthammer, M; Molinaro, A; Narayan, D; Pelizzola, M; Picardo, M; Sznol, M; Tran, N; Zhang, W1
Ibrahim, SM; Kunz, M; Schultz, J; Vera, J1
Fan, J; Niles, RM; Zhu, GZ1
Bhat, KM; Devi, S; Maddodi, N; Setaluri, V; Zhang, SC1
Denner, J; Fiebig, U; Kurth, R; Stengel, S1
Altomonte, M; Calabrò, L; Colizzi, F; Coral, S; Covre, A; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Nicolay, HJ; Sigalotti, L1
Halaban, R; Krauthammer, M; Ma, S; Rubinstein, JC; Tran, N1
Collnot, EM; Denzer, N; Essa, S; Klein, R; Mahlknecht, U; Reichrath, J; Tilgen, W1
Dar, AA; de Semir, D; Federman, S; Kashani-Sabet, M; Majid, S; Nosrati, M1
Bazhin, AV; De Smet, C; Golovastova, MO; Philippov, PP; Schmidt, J1
Certa, U; Foser, S; Scott, R; Siegrist, F1
Califano, JA; Mithani, SK; Smith, IM1
Aurelian, L; Lee, KS; Li, B; Liu, J; Smith, CC1
Chen, DW; Liu, QY; Wang, HZ; Xie, LP; Zhang, RQ1
Essa, S; Mahlknecht, U; Montenarh, M; Reichrath, J; Reichrath, S; Vogt, T1
Cheung, KH; Holford, ME; Krauthammer, M; McCusker, JP1
Dai, X; Wang, Y; Zhang, F1
Howell, PM; Liu, S; Riker, AI1
Bernardo, V; da Silva, DC; de Souza, CF; Jasiulionis, MG; Lopes, JD; Mai, S; Monteiro, AC; Silva, AG; Xander, P1
Colizzi, F; Coral, S; Covre, A; Danielli, R; Fratta, E; Maio, M; Nicolay, HJ; Parisi, G; Sigalotti, L; Taverna, P1
Beumer, JH; Buch, SC; Christner, S; Egorin, MJ; Kirkwood, JM; Lin, Y; Moschos, S; Tarhini, AA; Tawbi, HA1
Borden, EC; Fruehauf, JP; Haney, R; Jacobs, BS; Lindner, DJ; Tuthill, R; Wu, Y1
Bezrookove, V; Dar, AA; de Semir, D; Kashani-Sabet, M; Majid, S; Miller, JR; Nosrati, M; Rittsteuer, C; Sagebiel, R; Tong, S1
Bert, T; Gangsauge, S; Lubomierski, N; Münch, K; Prasnikar, N; Printz, H; Robbel, C; Simon, B1
Altomonte, M; Colizzi, F; Coral, S; Fonsatti, E; Maio, M; Sigalotti, L1
Frants, RR; Gruis, NA; Hurks, MHMH; Jager, MJ; Krijgsman, E; Ksander, BR; Pavey, S; Tensen, CP; van der Velden, PA; Willemze, R; Zuidervaart, W1
Gołab, J; Jakóbisiak, M; Kamiński, R; Kozar, K; Lasek, W; Machaj, E; Mackiewicz, A; Ołdak, T; Switaj, T; Wysocki, PJ1
Guan, X; Koganehira, Y; Oguchi, M; Sagara, J; Saida, T; Taniguchi, S; Yokoyama, T1
Heng, HH; Iwata, J; Liang, SB; Ohtsuki, Y; Sonobe, H; Takeuchi, T; Ye, CJ1
Grossman, D; Hanks, AN; Jones, DA; Karpf, AR; Lasek, AW; Ririe, TO1
Blaschke, B; Knobbe, CB; Reifenberger, G; Reifenberger, J; Ruzicka, T; Schulte, KW; Sterzinger, AA1
Akasaka, T; Maesawa, C; Masuda, T; Wada, K1
Golab, J; Grzela, T; Jakobisiak, M; Kaminski, R; Koronkiewicz, M; Kozar, K; Niderla, J; Skierski, JS; Wilczynski, G1
Altomonte, M; Colizzi, F; Coral, S; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Sigalotti, L; Tanzarella, S; Traversari, C1
Furuta, J; Kaneda, A; Otsuka, F; Sugimura, T; Umebayashi, Y; Ushijima, T1
Hoon, DS; Huang, S; Kim, J; Koyanagi, K; Mori, T; Takeuchi, H; Umetani, N; Yamano, T1
Chang, CC; Ferrone, S; Lin, AF; Yan, WH1
Ferrone, S; Kageshita, T; Karpf, AR; Luo, W; Wakasugi, S; Wang, X1
Jager, M; Ono, SJ; Radosevich, M1
Hoon, DS; Kitago, M; Martinez, SR; Mori, T; Morton, DL; Nguyen, SL; O'Day, SJ; Tanemura, A; Tran, AN; Umetani, N; Wang, HJ1
Dressman, HK; Gollob, JA; Issa, JP; Jelinek, J; Moran, K; Peterson, BL; Richmond, T; Sciambi, CJ; Thoreson, M1
Bosenberg, M; Bradbury, CM; Curley, DP; Duraisamy, S; Hobbs, C; Muthusamy, V; Nelson, B1
Bandle, R; Clair, T; Koh, E; Roberts, DD; Stracke, ML1
Bazhin, AV; Eichmüller, SB; Schadendorf, D; Schnölzer, M; Wiedemann, N1
Coral, S; Covre, A; Maio, M; Natali, PG; Nicolay, HJ; Sigalotti, L1
Furuta, J; Kikuchi, K; Miyagi, Y; Nakagawa, H; Nakanishi, Y; Nobeyama, Y; Okochi-Takada, E; Ushijima, T; Yamamoto, A1
Altomonte, M; Calabrò, L; Colizzi, F; Fonsatti, E; Guidoboni, M; Maio, M; Marincola, FM; Nicolay, HJ; Pezzani, L; Sigalotti, L1
Bae, SI; Borden, EC; Cheriyath, V; Jacobs, BS; Reu, FJ1
Gollob, JA; Sciambi, CJ1
Brasseur, F; De Plaen, E; De Smet, C; Kholmanskikh, O; Loriot, A1
Coppock, DL; Straus, DS1
Herlyn, M; Johnson, B; Lassam, N; Rosenberg, SA; Salgaller, M; Samid, D; Treisman, J; Weber, J1
Creagan, ET; Hartmann, LC; Loprinzi, CL; Schaid, DJ1
Boon, T; Brasseur, F; De Backer, O; De Smet, C; Faraoni, I; Lurquin, C1
Carrel, S; Cerottini, JC; Rimoldi, D; Schreyer, M; Spagnoli, G1
Boon, T; De Plaen, E; De Smet, C; Naerhuyzen, B; Szikora, JP1
Chen, PW; Ksander, BR; Murray, TG; Reddy, R; Salgaller, ML; Uno, T1
Altomonte, M; Cattarossi, I; Cattelan, A; Coral, S; Gasparollo, A; Maio, M; Sigalotti, L; Visintin, A1
Arden, KC; Boon, T; Boretti, M; Brasseur, F; Chomez, P; Czekay, S; De Backer, O; De Plaen, E; De Smet, C; Van den Eynde, B; van der Bruggen, P; Vantomme, V; Viars, CS1
Adema, GJ; de Bruijn, DR; de Vries, TJ; dos Santos, NR; Kater-Baats, E; Ruiter, DJ; Schreurs, MW; Torensma, R; van Kessel, AG; van Muijen, GN1
Chen, GA; Fischette, MR; Guo, ZS; Hong, JA; Nguyen, DM; Ohnmacht, GA; Schrump, DS; Weiser, TS1
Altomonte, M; Cattarossi, I; Ciullo, M; Coral, S; Gasparollo, A; Guardiola, J; Maio, M; Prisco, A; Sigalotti, L1
Christmann, M; Kaina, B; Lage, H; Pick, M; Schadendorf, D1
Bergman, W; Frants, RR; Gruis, NA; Hurks, H; Jager, MJ; Metzelaar-Blok, JA; Monique, H; van der Velden, PA1
Gorelik, E; Huang, X; Li, M; Orucevic, A1
Garrido, F; Lionello, I; Mendez, R; Ruiz-Cabello, F; Serrano, A; Tanzarella, S; Traversari, C1
den Hollander, AI; Ruiter, DJ; van Kraats, AA; van Muijen, GN; Weidle, UH; Zendman, AJ1
Biesta, P; Quinten, E; van den Elsen, PJ; van der Stoep, N1
Bellet, RE; Berd, D; Catalano, RB; Mastrangelo, MJ1
Bellet, RE; Berd, D; Danna, V; Mastrangelo, MJ1
Abbruzzese, JL; Frost, P1
Grant, JH; Kudlow, JE; Meluch, AA; Paterson, AJ; Shin, TH1
Parsons, PG; Takahashi, H1
Gorelik, E; Herberman, RB; Overton, R; Peppoloni, S1
Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL1
Everett, CA; Hart, IR; Ormerod, EJ1
Everett, CA; Finch, M; Hart, IR; Ormerod, EJ1
Bernheim, J; Buyssens, N; Cortvrindt, R; Roobol, K1
Abele, R; Bruntsch, U; Clavel, M; Dodion, P; Gundersen, S; Pinedo, HM; Renard, J; Smyth, J; van Glabbeke, M1
Barbieri, R; Fisher, PB; Gambari, R; Giacomini, P; Natali, PG; Piva, R; Tecce, R1

Reviews

1 review(s) available for azacitidine and Melanoma

ArticleYear
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.
    Clinical epigenetics, 2017, Volume: 9

    Topics: Azacitidine; Biomarkers, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Melanoma; MicroRNAs; Prognosis

2017

Trials

7 trial(s) available for azacitidine and Melanoma

ArticleYear
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 12-15, Volume: 25, Issue:24

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; CD8-Positive T-Lymphocytes; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Ipilimumab; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Patient Safety; Programmed Cell Death 1 Receptor; Survival Rate; Treatment Outcome

2019
A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations.
    Investigational new drugs, 2014, Volume: 32, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA Methylation; Female; Humans; Interferon alpha-2; Interferon-alpha; Leukocyte Count; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neutropenia; Polyethylene Glycols; Recombinant Proteins; T-Lymphocyte Subsets

2014
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epigenomics; Eye Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Panobinostat; Skin Neoplasms; Temozolomide; Treatment Outcome

2014
Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; Disease-Free Survival; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Skin Neoplasms; Temozolomide

2013
Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Renal Cell; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Fetal Hemoglobin; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Injections, Intravenous; Injections, Subcutaneous; Interleukin-2; Kidney Neoplasms; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Predictive Value of Tests; Treatment Outcome

2006
A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma.
    American journal of clinical oncology, 1993, Volume: 16, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biopsy; Chest Pain; Female; Humans; Immunologic Factors; Infusions, Intravenous; Male; Melanoma; Middle Aged; Nausea; Remission Induction; Risk Factors; Severity of Illness Index; Survival Rate; Vomiting

1993
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Clinical Trials as Topic; Decitabine; Female; Hematologic Diseases; Humans; Male; Melanoma; Middle Aged; Neoplasms

1987

Other Studies

104 other study(ies) available for azacitidine and Melanoma

ArticleYear
Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:6

    Topics: Animals; Antineoplastic Agents; Azacitidine; Hydrolysis; Leukemia L1210; Leukemia, Experimental; Melanoma; Mice; Neoplasms, Experimental

1977
Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:4

    Topics: Azacitidine; Child, Preschool; GTP Phosphohydrolases; Humans; Male; Melanoma; Membrane Proteins; Meningeal Neoplasms; Mitogen-Activated Protein Kinase Kinases; Mutation; Nevus, Pigmented; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Skin Neoplasms

2022
5‑Aza‑dC suppresses melanoma progression by inhibiting GAS5 hypermethylation.
    Oncology reports, 2022, Volume: 48, Issue:1

    Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mice; Mice, Nude; RNA, Long Noncoding

2022
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
    European journal of immunology, 2021, Volume: 51, Issue:6

    Topics: Animals; Azacitidine; Chemoradiotherapy; Disease Models, Animal; Drug Synergism; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Signal Transduction; Treatment Outcome

2021
Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells.
    Cancer letters, 2017, 09-10, Volume: 403

    Topics: Antigens, Neoplasm; Azacitidine; Binding Sites; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Kruppel-Like Transcription Factors; Melanoma; Promoter Regions, Genetic; Protein Binding; RNA Interference; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Transfection; Up-Regulation

2017
Silencing of metallothionein 1A gene in melanoma.
    Journal of dermatological science, 2017, Volume: 88, Issue:2

    Topics: 5' Untranslated Regions; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Child; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanocytes; Melanoma; Metallothionein; Middle Aged; Nevus, Pigmented; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Young Adult

2017
Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma.
    BMC cancer, 2018, 01-26, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carboplatin; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Damage; DNA Methylation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Promoter Regions, Genetic

2018
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
    Cancer immunology, immunotherapy : CII, 2013, Volume: 62, Issue:7

    Topics: Antigen-Presenting Cells; Antigens, Neoplasm; Azacitidine; B-Lymphocytes; Cancer Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Melanoma; Neoplasms; RNA, Messenger; Telomerase; Telomere; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat

2013
Potential role of 5-aza-2'-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer.
    Surgery, 2013, Volume: 154, Issue:6

    Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression; Humans; Immunotherapy; Indoles; MAP Kinase Signaling System; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Sulfonamides; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms

2013
Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.
    Theoretical biology & medical modelling, 2014, May-07, Volume: 11 Suppl 1

    Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Female; Gene Regulatory Networks; Genes, Neoplasm; Humans; Melanoma; Signal Transduction; Transcription, Genetic; Up-Regulation

2014
The demethylating agent 5-Aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma.
    Investigative ophthalmology & visual science, 2014, Aug-21, Volume: 55, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colony-Forming Units Assay; Decitabine; DNA Modification Methylases; DNA, Neoplasm; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Neoplasms, Experimental; Skin Neoplasms; Uveal Neoplasms

2014
A novel tumor suppressor function of Kindlin-3 in solid cancer.
    Oncotarget, 2014, Oct-15, Volume: 5, Issue:19

    Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin

2014
Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma.
    Biochimica et biophysica acta, 2015, Volume: 1849, Issue:3

    Topics: Adult; Azacitidine; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Humans; Melanoma; Promoter Regions, Genetic; Tumor Suppressor Protein p14ARF; Uveal Neoplasms

2015
DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells.
    Melanoma research, 2015, Volume: 25, Issue:5

    Topics: Animals; Azacitidine; Cell Line, Tumor; Cells, Cultured; DNA Methylation; Dog Diseases; Dogs; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Melanocytes; Melanoma; MicroRNAs; Mouth Neoplasms

2015
Elucidating the immunological effects of 5-azacytidine treatment in patients with myelodysplastic syndrome and identifying new conditional ligands and T-cell epitopes of relevance in melanoma.
    Danish medical journal, 2015, Volume: 62, Issue:8

    Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Epitopes, T-Lymphocyte; HLA-A Antigens; Humans; Immunologic Factors; Leukocytes, Mononuclear; Ligands; Melanoma; Myelodysplastic Syndromes; Nodal Protein; T-Lymphocytes; White People

2015
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
    Cell, 2015, Aug-27, Volume: 162, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Colorectal Neoplasms; DNA Methylation; Female; Humans; Interferon Type I; Melanoma

2015
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
    Cell, 2015, Aug-27, Volume: 162, Issue:5

    Topics: Animals; Azacitidine; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Endogenous Retroviruses; Female; Humans; Immunotherapy; Interferon Type I; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; RNA, Double-Stranded

2015
A novel apoptosis-inducing mechanism of 5-aza-2'-deoxycitidine in melanoma cells: Demethylation of TNF-α and activation of FOXO1.
    Cancer letters, 2015, Dec-28, Volume: 369, Issue:2

    Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; DNA Methylation; Dogs; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Prognosis; Signal Transduction; Tumor Necrosis Factor-alpha

2015
The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.
    BioMed research international, 2015, Volume: 2015

    Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Silencing; Melanocytes; Melanoma; Mice; MicroRNAs; Promoter Regions, Genetic

2015
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
    BMC cancer, 2016, Feb-22, Volume: 16

    Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Transketolase; Up-Regulation

2016
MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses.
    Journal of immunology (Baltimore, Md. : 1950), 2016, 09-15, Volume: 197, Issue:6

    Topics: Antigens, Neoplasm; Azacitidine; B7-1 Antigen; B7-2 Antigen; B7-H1 Antigen; Cell Line, Tumor; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Melanoma; Neoplasm Proteins; Receptors, Antigen, T-Cell; T-Lymphocytes; Valproic Acid

2016
Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma.
    Oncology reports, 2016, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Child; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; RNA, Messenger

2016
Combining Type I Interferons and 5-Aza-2'-Deoxycitidine to Improve Anti-Tumor Response against Melanoma.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:1

    Topics: Analysis of Variance; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Interferon Type I; Melanoma; Mice; Mice, Inbred C57BL; Skin Neoplasms; Statistics, Nonparametric

2017
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
    Human pathology, 2017, Volume: 60

    Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Melanoma; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Skin Neoplasms; Time Factors; Treatment Outcome; Up-Regulation; Uveal Neoplasms

2017
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
    Oncotarget, 2017, Jan-03, Volume: 8, Issue:1

    Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Dioxygenases; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Demethylation; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Small Interfering; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays

2017
Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.
    Genes, chromosomes & cancer, 2009, Volume: 48, Issue:1

    Topics: Azacitidine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; Esophageal Neoplasms; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glioma; Heat-Shock Proteins; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Proteins; Microfilament Proteins; Neuropeptides; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction

2009
PAX4 has the potential to function as a tumor suppressor in human melanoma.
    International journal of oncology, 2008, Volume: 33, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Replication; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Paired Box Transcription Factors; RNA, Messenger; Skin Neoplasms; Time Factors; Transfection; Tumor Suppressor Proteins

2008
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
    Cancer research, 2009, Jan-15, Volume: 69, Issue:2

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Survival; Decitabine; DNA Methylation; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesions; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Melanoma; Phosphorylation; Promoter Regions, Genetic; rap1 GTP-Binding Proteins; Transfection

2009
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications.
    PloS one, 2009, Volume: 4, Issue:2

    Topics: Apoptosis; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Computational Biology; Decitabine; DNA Damage; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Melanoma

2009
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.
    Molecular cancer, 2009, Jul-30, Volume: 8

    Topics: 14-3-3 Proteins; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cellular Senescence; CpG Islands; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Exonucleases; Exoribonucleases; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Neoplasm Metastasis; Neoplasm Proteins; Phenylbutyrates; RNA, Messenger

2009
Expression and function of CD9 in melanoma cells.
    Molecular carcinogenesis, 2010, Volume: 49, Issue:1

    Topics: Animals; Antigens, CD; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Infant, Newborn; Melanocytes; Melanoma; Membrane Glycoproteins; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetraspanin 29; Transfection

2010
Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1.
    The Journal of biological chemistry, 2010, Jan-01, Volume: 285, Issue:1

    Topics: Amino Acid Substitution; Animals; Azacitidine; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Cell Line, Tumor; CpG Islands; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; MAP Kinase Signaling System; Melanoma; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mutant Proteins; Neurons; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Response Elements; Transcription Factor HES-1; Transcription, Genetic

2010
Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation.
    Genes, chromosomes & cancer, 2010, Volume: 49, Issue:5

    Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Endogenous Retroviruses; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Gene Silencing; Humans; Melanoma; Promoter Regions, Genetic; RNA Splicing; Sequence Analysis, RNA; Sulfites; Terminal Repeat Sequences; Viral Envelope Proteins

2010
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma.
    Journal of cellular physiology, 2010, Volume: 223, Issue:2

    Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Clone Cells; Cloning, Molecular; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Inheritance Patterns; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Tumor Cells, Cultured

2010
Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma.
    BMC medical genomics, 2010, Feb-09, Volume: 3

    Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Genome, Human; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Tumor Suppressor Proteins; Up-Regulation

2010
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 121, Issue:1-2

    Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; MicroRNAs; Receptors, Calcitriol; Signal Transduction; Skin Neoplasms; Time Factors; Vitamin D

2010
Functional modulation of IGF-binding protein-3 expression in melanoma.
    The Journal of investigative dermatology, 2010, Volume: 130, Issue:8

    Topics: Apoptosis; Azacitidine; Base Sequence; Caspase 3; Cell Division; Cell Line, Tumor; Cell Survival; Chromatin; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Melanoma; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms

2010
Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells.
    Experimental dermatology, 2010, Volume: 19, Issue:11

    Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Exons; Gene Expression Regulation, Neoplastic; Humans; Lung; Melanoma; Neoplasms; Promoter Regions, Genetic; Recoverin; Skin; Small Cell Lung Carcinoma

2010
Interferon-alpha induces reversible DNA demethylation of the interferon-induced transmembrane protein-3 core promoter in human melanoma cells.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2011, Volume: 31, Issue:8

    Topics: Azacitidine; Biomarkers, Pharmacological; Cell Growth Processes; Cell Line, Tumor; Chemotactic Factors; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Melanoma; Membrane Proteins; Promoter Regions, Genetic; RNA-Binding Proteins; S100 Proteins; Transforming Growth Factor beta; Transgenes

2011
Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.
    Melanoma research, 2011, Volume: 21, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Proliferation; Comparative Genomic Hybridization; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomics; Humans; Male; Melanoma; Middle Aged; Oligonucleotide Array Sequence Analysis; Skin Neoplasms; Transfection

2011
The Levels of H11/HspB8 DNA methylation in human melanoma tissues and xenografts are a critical molecular marker for 5-Aza-2'-deoxycytidine therapy.
    Cancer investigation, 2011, Volume: 29, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle; Decitabine; DNA Methylation; Female; Heat-Shock Proteins; Humans; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Molecular Chaperones; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays

2011
Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells.
    Environmental toxicology and pharmacology, 2011, Volume: 32, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Division; Cell Proliferation; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; G2 Phase; Melanoma; Mice; Tumor Cells, Cultured

2011
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
    Anticancer research, 2012, Volume: 32, Issue:1

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cell Proliferation; Cells, Cultured; Epigenomics; Humans; Melanocytes; Melanoma; MicroRNAs; Real-Time Polymerase Chain Reaction; Receptors, Calcitriol; RNA, Messenger; Skin Neoplasms; Vitamin D

2012
A semantic web framework to integrate cancer omics data with biological knowledge.
    BMC bioinformatics, 2012, 01-25, Volume: 13 Suppl 1

    Topics: Azacitidine; Database Management Systems; Decitabine; Drug Resistance, Neoplasm; Epigenomics; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Humans; Internet; Melanoma; Semantics; Transcription Factors; Translational Research, Biomedical

2012
5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis.
    Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:7

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cholesterol; Decitabine; Dipeptidyl Peptidase 4; DNA Methylation; Epigenesis, Genetic; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Neoplastic; Geranyltranstransferase; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Mass Spectrometry; Melanoma; Proteomics; RNA, Small Interfering

2012
Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells.
    Annals of surgical oncology, 2013, Volume: 20, Issue:5

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; MicroRNAs; Oligonucleotide Array Sequence Analysis; Skin; Skin Neoplasms; Up-Regulation

2013
Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Azacitidine; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Hydroxamic Acids; Karyotyping; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Phenotype; Risk; Skin Neoplasms

2012
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.
    Cancer immunology, immunotherapy : CII, 2013, Volume: 62, Issue:3

    Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Cytotoxicity, Immunologic; DNA Methylation; Humans; Immunomodulation; Immunophenotyping; Immunotherapy; Melanoma; Neoplasms

2013
Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis.
    Matrix biology : journal of the International Society for Matrix Biology, 2013, Mar-11, Volume: 32, Issue:2

    Topics: Animals; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Methylation; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Xenograft Model Antitumor Assays

2013
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.
    Journal of the National Cancer Institute, 2013, Mar-20, Volume: 105, Issue:6

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatin Immunoprecipitation; DNA Methylation; Epithelial-Mesenchymal Transition; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Luciferases; Melanoma; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Point Mutation; Proto-Oncogene Proteins c-mdm2; Real-Time Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Transplantation, Heterologous; Tumor Suppressor Protein p53; Up-Regulation

2013
Expression spectrum and methylation-dependent regulation of melanoma antigen-encoding gene family members in pancreatic cancer cells.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2002, Volume: 2, Issue:2

    Topics: Adult; Aged; Antigens, Neoplasm; Azacitidine; Culture Techniques; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression; Gene Expression Regulation; Humans; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Tumor Cells, Cultured; Up-Regulation

2002
Methylation-regulated expression of HLA class I antigens in melanoma.
    International journal of cancer, 2003, Jun-20, Volume: 105, Issue:3

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Genes, MHC Class I; HLA Antigens; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; Tumor Cells, Cultured; Up-Regulation

2003
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.
    International journal of cancer, 2003, Sep-10, Volume: 106, Issue:4

    Topics: Azacitidine; Biomarkers, Tumor; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Probes; Down-Regulation; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Liver Neoplasms; Melanoma; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Uveal Neoplasms

2003
Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8

    Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; CD4 Antigens; CD8 Antigens; Cell Line, Tumor; Cell Survival; Decitabine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Immunotherapy; Interferon-gamma; Interleukin-12; Interleukin-4; Lectins, C-Type; Lymph Nodes; Lymphocytes; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, SCID; Models, Genetic; Neutrophils; NK Cell Lectin-Like Receptor Subfamily B; Protein Biosynthesis; Proteins; Time Factors

2003
ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma.
    International journal of cancer, 2003, Nov-01, Volume: 107, Issue:2

    Topics: Apoptosis; Azacitidine; Blotting, Western; CARD Signaling Adaptor Proteins; Caspase 1; CpG Islands; Cytoskeletal Proteins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; DNA, Neoplasm; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Nevus, Pigmented; Polymerase Chain Reaction; Proteins; Skin Neoplasms; Sulfites; Tumor Cells, Cultured

2003
Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.
    The American journal of pathology, 2003, Volume: 163, Issue:4

    Topics: Actins; Amino Acid Sequence; Azacitidine; Blotting, Northern; Blotting, Western; Cloning, Molecular; Decitabine; DNA, Complementary; Down-Regulation; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Melanoma; Microfilament Proteins; Molecular Sequence Data; Neoplasm Proteins; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases; Yeasts

2003
Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.
    Molecular pharmacology, 2004, Volume: 65, Issue:1

    Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Epithelial Cells; Gene Expression Regulation; Humans; Melanocytes; Melanoma; Melanoma-Specific Antigens; Multigene Family; Neoplasm Proteins; Transcriptional Activation

2004
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
    International journal of cancer, 2004, Apr-10, Volume: 109, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins

2004
Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells.
    The Journal of investigative dermatology, 2004, Volume: 122, Issue:3

    Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Serpins

2004
Demethylating agent 5-aza-2'-deoxycytidine enhances expression of TNFRI and promotes TNF-mediated apoptosis in vitro and in vivo.
    Oncology reports, 2004, Volume: 12, Issue:3

    Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Separation; CpG Islands; Decitabine; DNA Fragmentation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Proteins; Ribonucleases; RNA; Time Factors; Tumor Necrosis Factor-alpha

2004
Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine.
    Cancer research, 2004, Dec-15, Volume: 64, Issue:24

    Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; HLA-B Antigens; Humans; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms

2004
Silencing of the thrombomodulin gene in human malignant melanoma.
    Melanoma research, 2005, Volume: 15, Issue:1

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanocytes; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms; Thrombomodulin

2005
Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells.
    Cancer research, 2005, Mar-01, Volume: 65, Issue:5

    Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation

2005
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
    Cell research, 2005, Volume: 15, Issue:7

    Topics: Azacitidine; Calreticulin; Cell Line, Tumor; Choriocarcinoma; Decitabine; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Melanoma; Methylation; Promoter Regions, Genetic; Transcription, Genetic

2005
Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.
    Oncogene, 2006, May-11, Volume: 25, Issue:20

    Topics: Antigens, Neoplasm; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Melanoma; Promoter Regions, Genetic; Tumor Cells, Cultured

2006
Inhibition of MHC class II gene expression in uveal melanoma cells is due to methylation of the CIITA gene or an upstream activator.
    Experimental and molecular pathology, 2007, Volume: 82, Issue:1

    Topics: Azacitidine; Base Sequence; Blotting, Southern; Cell Line, Tumor; DNA Methylation; Eye; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; HeLa Cells; Humans; Interferon-gamma; Melanoma; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Uveal Neoplasms

2007
Estrogen receptor-alpha methylation predicts melanoma progression.
    Cancer research, 2006, Jul-01, Volume: 66, Issue:13

    Topics: Age Factors; Azacitidine; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Sex Factors

2006
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
    Cancer research, 2006, Dec-01, Volume: 66, Issue:23

    Topics: Animals; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Syk Kinase; Transfection; Transplantation, Heterologous; Tumor Suppressor Proteins

2006
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
    Cancer letters, 2007, May-18, Volume: 250, Issue:1

    Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Hydroxamic Acids; Lysophospholipids; Melanoma; Nerve Tissue Proteins; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; RNA-Binding Proteins; RNA, Messenger; Sphingosine

2007
Expression of GAGE family proteins in malignant melanoma.
    Cancer letters, 2007, Jun-28, Volume: 251, Issue:2

    Topics: Antigens, Neoplasm; Autoantibodies; Azacitidine; Cell Line, Tumor; Humans; Hydroxamic Acids; Immunohistochemistry; Melanoma; Neoplasm Proteins; Recombinant Proteins; Skin Neoplasms

2007
5-AZA-2'-deoxycytidine in cancer immunotherapy: a mouse to man story.
    Cancer research, 2007, Mar-15, Volume: 67, Issue:6

    Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Humans; Immunotherapy, Adoptive; Melanoma; Mice; Xenograft Model Antitumor Assays

2007
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.
    International journal of cancer, 2007, Jul-15, Volume: 121, Issue:2

    Topics: Azacitidine; Cell Line, Tumor; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation; Gene Silencing; Glycoproteins; Humans; Immunohistochemistry; Melanoma; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Ultraviolet Rays

2007
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jun-01, Volume: 13, Issue:11

    Topics: Azacitidine; Cell Line, Tumor; Decitabine; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; gp100 Melanoma Antigen; Histocompatibility Antigens Class I; Humans; Immunotherapy; Interferon-gamma; Melanoma; Membrane Glycoproteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; T-Lymphocytes, Cytotoxic; Up-Regulation

2007
Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL.
    Oncogene, 2008, Jan-17, Volume: 27, Issue:4

    Topics: Apoptosis; Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Interferons; Melanoma; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2008
Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Sep-01, Volume: 13, Issue:17

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Chemotactic Factors; Decitabine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Interferon-gamma; Melanoma; S100 Proteins; Tumor Cells, Cultured; Uveal Neoplasms

2007
Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.
    International journal of cancer, 2008, Feb-15, Volume: 122, Issue:4

    Topics: Antigens, Neoplasm; Azacitidine; Blotting, Western; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Transfection; Tumor Cells, Cultured

2008
Growth control variant cell line having increased serum requirement and decreased response to platelet-derived growth factor: reversion by 5-azacytidine.
    The Journal of cell biology, 1984, Volume: 99, Issue:5

    Topics: Animals; Azacitidine; Blood; Cell Division; Cell Line; Clone Cells; DNA; Fibroblasts; Genetic Variation; Hybrid Cells; Insulin; Melanoma; Mice; Platelet-Derived Growth Factor

1984
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.
    Cancer research, 1994, Apr-01, Volume: 54, Issue:7

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Cell Line; Cytotoxicity, Immunologic; Decitabine; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Lymphocytes; Lymphocytes, Tumor-Infiltrating; Melanocytes; Melanoma; Melanoma-Specific Antigens; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured

1994
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-09, Volume: 93, Issue:14

    Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured

1996
Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells.
    International journal of cancer, 1996, Jul-29, Volume: 67, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; Cross Reactions; Decitabine; Immunohistochemistry; Melanoma; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Recombinant Proteins; RNA, Messenger; Tumor Cells, Cultured

1996
Alternative promoters of gene MAGE4a.
    Genomics, 1997, Mar-01, Volume: 40, Issue:2

    Topics: Alternative Splicing; Amino Acid Sequence; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cloning, Molecular; Decitabine; DNA-Binding Proteins; DNA, Neoplasm; Exons; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Placenta; Promoter Regions, Genetic; Restriction Mapping; Rhabdomyosarcoma; RNA, Messenger; Sequence Analysis, DNA; Testis; Tumor Cells, Cultured

1997
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.
    Clinical & experimental metastasis, 1997, Volume: 15, Issue:5

    Topics: Antigens, Neoplasm; Azacitidine; Clone Cells; Decitabine; Disease Progression; Eye Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Metastasis; Neoplasm Proteins; Tumor Cells, Cultured

1997
Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR).
    Journal of immunotherapy (Hagerstown, Md. : 1997), 1999, Volume: 22, Issue:1

    Topics: Alleles; Antigens, Neoplasm; Azacitidine; Blotting, Western; CD58 Antigens; Decitabine; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Intercellular Adhesion Molecule-1; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured; Up-Regulation

1999
Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.
    Cancer research, 1999, Jul-01, Volume: 59, Issue:13

    Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Chromosome Mapping; Cloning, Molecular; COS Cells; Decitabine; Exons; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Male; Melanoma; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Neoplasms; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Testis; Transcriptional Activation; Transfection; Tumor Cells, Cultured; X Chromosome

1999
Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Adult; Antibodies, Monoclonal; Antibody Specificity; Azacitidine; Caco-2 Cells; Cell Nucleus; Child; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunohistochemistry; K562 Cells; Male; Melanoma; Microscopy, Fluorescence; Neoplasm Proteins; Recombinant Fusion Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sequence Deletion; Testis; Tumor Cells, Cultured

2000
Induction of MAGE-3 expression in lung and esophageal cancer cells.
    The Annals of thoracic surgery, 2001, Volume: 71, Issue:1

    Topics: Adenocarcinoma; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antigens, Neoplasm; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Depsipeptides; DNA Modification Methylases; Enzyme Inhibitors; Esophageal Neoplasms; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lung Neoplasms; Melanoma; Neoplasm Proteins; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2001
Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma.
    International journal of cancer, 2001, Feb-15, Volume: 91, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; DNA, Complementary; Down-Regulation; Flow Cytometry; HLA-A Antigens; HLA-B Antigens; Humans; Interferon-gamma; Leukocytes, Mononuclear; Melanoma; Molecular Sequence Data; Neoplasms; Phenotype; Recombinant Proteins; Ribonucleases; RNA, Messenger; Sequence Homology, Nucleic Acid; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation

2001
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
    International journal of cancer, 2001, Apr-01, Volume: 92, Issue:1

    Topics: Antineoplastic Agents; Azacitidine; Blotting, Southern; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Gene Amplification; Gene Expression; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Tumor Cells, Cultured

2001
Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.
    Cancer research, 2001, Jul-01, Volume: 61, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Azacitidine; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Uveal Neoplasms

2001
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes.
    Clinical & experimental metastasis, 2000, Volume: 18, Issue:4

    Topics: Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, MHC Class I; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melanoma; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tumor Cells, Cultured; Up-Regulation

2000
Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment.
    International journal of cancer, 2001, Oct-15, Volume: 94, Issue:2

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epitopes, T-Lymphocyte; Genes, MHC Class I; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured

2001
Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis.
    International journal of cancer, 2002, Jan-10, Volume: 97, Issue:2

    Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Blotting, Northern; Chromosome Mapping; Cloning, Molecular; Decitabine; Disease Progression; DNA Modification Methylases; DNA Primers; DNA, Complementary; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testis; Transfection; Tumor Cells, Cultured

2002
Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines.
    International journal of cancer, 2002, Feb-01, Volume: 97, Issue:4

    Topics: Azacitidine; Burkitt Lymphoma; Carcinoma; Cell Differentiation; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, MHC Class II; Genes, Reporter; HLA-DR Antigens; Humans; Interferon-gamma; Melanoma; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Signal Transduction; Trans-Activators; Transfection; Tumor Cells, Cultured

2002
Phase II study of subcutaneously administered 5-azacytidine (NSC-102816) in patients with metastatic malignant melanoma.
    Medical and pediatric oncology, 1978, Volume: 4, Issue:1

    Topics: Azacitidine; Bone Marrow; Dacarbazine; Drug Evaluation; Drug Resistance; Female; Humans; Injections, Subcutaneous; Male; Melanoma; Neoplasm Metastasis; Vomiting

1978
Evaluation of a "nude" mouse-human tumor panel as a predictive secondary screen for cancer chemotherapeutic agents.
    Journal of the National Cancer Institute, 1979, Volume: 63, Issue:5

    Topics: Animals; Antineoplastic Agents; Azacitidine; Carmustine; Dacarbazine; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance; Female; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms, Experimental

1979
Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cisplatin; Decitabine; DNA, Neoplasm; Drug Resistance; Drug Synergism; Humans; Melanoma; Methylation; Mice; Sensitivity and Specificity; Tubercidin; Tumor Cells, Cultured

1992
5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.
    Molecular and cellular biology, 1992, Volume: 12, Issue:9

    Topics: Azacitidine; Base Sequence; DNA; Gene Expression Regulation; Humans; Kinetics; Melanoma; Methylation; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured

1992
In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression.
    Pigment cell research, 1990, Volume: 3, Issue:5

    Topics: Antigens, Neoplasm; Azacitidine; Butyrates; Butyric Acid; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Dimethyl Sulfoxide; Dimethylformamide; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Melanins; Melanoma; Microscopy, Electron; Monophenol Monooxygenase; Organelles; Phenotype

1990
Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N'-nitronitrosoguanidine.
    Cancer research, 1985, Volume: 45, Issue:11 Pt 1

    Topics: Animals; Antigens, Neoplasm; Azacitidine; Cross Reactions; Female; H-2 Antigens; Histocompatibility Antigens; Major Histocompatibility Complex; Melanoma; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL

1985
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis

1985
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
    Cancer research, 1986, Volume: 46, Issue:2

    Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation

1986
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
    Cancer research, 1986, Volume: 46, Issue:9

    Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methylation; Mice; Neoplasm Metastasis

1986
5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma.
    British journal of cancer, 1987, Volume: 56, Issue:3

    Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cells, Cultured; Cytidine; Decitabine; Drug Resistance; Melanoma; Mice; Mutation; Uridine

1987
Regulation of the expression of class II genes of the human major histocompatibility complex in tumor cells.
    Annals of the New York Academy of Sciences, 1987, Volume: 511

    Topics: Azacitidine; B-Lymphocytes; DNA, Neoplasm; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Interferons; Leukemia, Erythroblastic, Acute; Major Histocompatibility Complex; Melanoma; Methylation; Recombinant Proteins; Tumor Cells, Cultured

1987