azacitidine has been researched along with Malignant Melanoma in 112 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (9.82) | 18.7374 |
| 1990's | 11 (9.82) | 18.2507 |
| 2000's | 41 (36.61) | 29.6817 |
| 2010's | 46 (41.07) | 24.3611 |
| 2020's | 3 (2.68) | 2.80 |
| Authors | Studies |
|---|---|
| Abbasi, MM; Beisler, JA; Driscoll, JS; Kelley, JA | 1 |
| Feige, U; Hamed, E; Hanft, KM; Hettmer, S; Kaiser, M; Krengel, S; Meiss, F; Niemeyer, C; Pietsch, T; Schneider, M; Würtemberger, J | 1 |
| Chen, DX; Chen, L; Jiang, J; Niu, HT; Wang, X; Xie, R; Yang, CH; Zhai, L; Zhang, J; Zhang, YJ | 1 |
| Amato, G; Anichini, A; Azab, M; Bock, C; Coral, S; Covre, A; Cutaia, O; Danielli, R; Di Giacomo, AM; Fazio, C; Finotello, F; Fridman, WH; Giannarelli, D; Lacroix, L; Lazzeri, A; Lowder, J; Maio, M; Miracco, C; Monterisi, S; Nemc, A; Oganesian, A; Petitprez, F; Rieder, D; Sautès-Fridman, C; Sigalotti, L; Trajanoski, Z; Valente, M | 1 |
| Bassermann, F; Dahl, S; Haas, T; Heidegger, S; Poeck, H; Wintges, A | 1 |
| Bosenberg, M; Micevic, G; Theodosakis, N | 1 |
| Hwang, JT; Jeong, JC; Kim, EJ; Lee, YK; Park, UH; Um, SJ | 1 |
| Nakagawa, H; Nobeyama, Y | 1 |
| Bowden, NA; Budden, T; van der Westhuizen, A | 1 |
| Held, G; Kaddu-Mulindwa, D; Kubuschok, B; Neumann, F; Pfreundschuh, M; Preuss, KD; Roemer, K; Widmann, T; Zwick, C | 1 |
| Bernasconi, MJ; Cogdill, AP; Gunda, V; Parangi, S; Wargo, JA | 1 |
| Bassett, RL; Desai, JR; Hwu, WJ; Ilagan, JL; Issa, JP; Jelinek, J; Papadopoulos, NE; Plimack, ER; Sharma, P; Vence, LM | 1 |
| Deutsch, J; Frees, M; Laux, D; Leon-Ferre, R; Milhem, M; Smith, BJ; Xia, C | 1 |
| Capobianco, E; Cinti, C; El Baroudi, M; La Sala, D | 1 |
| Asnaghi, L; Eberhart, CG; Enke, R; Handa, JT; Merbs, SL; Rajaii, F | 1 |
| Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J | 1 |
| Biondo, C; Catalano, T; Lentini, M; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Haraguchi, T; Itamoto, K; Mizuno, T; Mori, T; Nakagawa, T; Noguchi, S | 1 |
| Frøsig, TM | 1 |
| Licht, JD | 1 |
| Akman, B; Baylin, SB; Beckmann, MW; Budhu, S; Buhu, S; Chan, TA; Chiappinelli, KB; Cope, LM; Desrichard, A; Hein, A; Henke, C; Li, H; Makarov, V; Merghoub, T; Mergoub, T; Pardoll, DM; Rote, NS; Slamon, DJ; Snyder, A; Strick, R; Strissel, PL; Wolchok, JD; Zahnow, CA | 1 |
| Igase, M; Mizuno, T; Mori, T; Noguchi, S | 1 |
| Gasque Schoof, CR; Izzotti, A; Jasiulionis, MG; Vasques, Ldos R | 1 |
| Anaka, M; Behren, A; Cebon, J; Chueh, AC; Davalos-Salas, M; Jayachandran, A; Lo, PH; Molania, R; Prithviraj, P; Walkiewicz, M | 1 |
| Coulie, PG; da Silva, M; Debets, R; Kunert, A; Lamers, C; Sleijfer, S; van Brakel, M; van Steenbergen-Langeveld, S | 1 |
| Chen, H; Jin, X; Jin, Z; Kim, KY; Roh, MR; Zheng, Z | 1 |
| Bracci, L; Buccione, C; Businaro, L; D'Urso, MT; De Ninno, A; Gerardino, A; Lucarini, V; Macchia, D; Macchia, I; Mattei, F; Mattia, G; Mozetic, P; Parolini, I; Peschiaroli, F; Puglisi, R; Rainer, A; Rossi, A; Schiavoni, G; Sestili, P; Spada, M; Trombetta, M; Zanetti, C; Ziccheddu, G | 1 |
| Beninati, C; Catalano, T; Teti, D; Venza, I; Venza, M; Visalli, M | 1 |
| Chen, L; Gong, F; Guo, Y; Jin, J; Li, R; Ma, RZ; Niu, Y; Shi, X; Zhang, L; Zhang, X | 1 |
| Bonazzi, VF; Hayward, NK; Irwin, D | 1 |
| Furukawa, H; Hamada, J; Hata, S; Maeda, K; Moriuchi, T; Murai, T; Saito, A; Tada, M; Tsutsumida, A; Yamamoto, Y | 1 |
| Cornelius, LA; Feng, Y; Gao, L; Yuan, L; Zhao, H; Zheng, H | 1 |
| Ariyan, S; Bacchiocchi, A; Cheng, E; Deng, M; Enghild, JJ; Halaban, R; Kluger, Y; Kovacs, D; Krauthammer, M; Molinaro, A; Narayan, D; Pelizzola, M; Picardo, M; Sznol, M; Tran, N; Zhang, W | 1 |
| Ibrahim, SM; Kunz, M; Schultz, J; Vera, J | 1 |
| Fan, J; Niles, RM; Zhu, GZ | 1 |
| Bhat, KM; Devi, S; Maddodi, N; Setaluri, V; Zhang, SC | 1 |
| Denner, J; Fiebig, U; Kurth, R; Stengel, S | 1 |
| Altomonte, M; Calabrò, L; Colizzi, F; Coral, S; Covre, A; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Nicolay, HJ; Sigalotti, L | 1 |
| Halaban, R; Krauthammer, M; Ma, S; Rubinstein, JC; Tran, N | 1 |
| Collnot, EM; Denzer, N; Essa, S; Klein, R; Mahlknecht, U; Reichrath, J; Tilgen, W | 1 |
| Dar, AA; de Semir, D; Federman, S; Kashani-Sabet, M; Majid, S; Nosrati, M | 1 |
| Bazhin, AV; De Smet, C; Golovastova, MO; Philippov, PP; Schmidt, J | 1 |
| Certa, U; Foser, S; Scott, R; Siegrist, F | 1 |
| Califano, JA; Mithani, SK; Smith, IM | 1 |
| Aurelian, L; Lee, KS; Li, B; Liu, J; Smith, CC | 1 |
| Chen, DW; Liu, QY; Wang, HZ; Xie, LP; Zhang, RQ | 1 |
| Essa, S; Mahlknecht, U; Montenarh, M; Reichrath, J; Reichrath, S; Vogt, T | 1 |
| Cheung, KH; Holford, ME; Krauthammer, M; McCusker, JP | 1 |
| Dai, X; Wang, Y; Zhang, F | 1 |
| Howell, PM; Liu, S; Riker, AI | 1 |
| Bernardo, V; da Silva, DC; de Souza, CF; Jasiulionis, MG; Lopes, JD; Mai, S; Monteiro, AC; Silva, AG; Xander, P | 1 |
| Colizzi, F; Coral, S; Covre, A; Danielli, R; Fratta, E; Maio, M; Nicolay, HJ; Parisi, G; Sigalotti, L; Taverna, P | 1 |
| Beumer, JH; Buch, SC; Christner, S; Egorin, MJ; Kirkwood, JM; Lin, Y; Moschos, S; Tarhini, AA; Tawbi, HA | 1 |
| Borden, EC; Fruehauf, JP; Haney, R; Jacobs, BS; Lindner, DJ; Tuthill, R; Wu, Y | 1 |
| Bezrookove, V; Dar, AA; de Semir, D; Kashani-Sabet, M; Majid, S; Miller, JR; Nosrati, M; Rittsteuer, C; Sagebiel, R; Tong, S | 1 |
| Bert, T; Gangsauge, S; Lubomierski, N; Münch, K; Prasnikar, N; Printz, H; Robbel, C; Simon, B | 1 |
| Altomonte, M; Colizzi, F; Coral, S; Fonsatti, E; Maio, M; Sigalotti, L | 1 |
| Frants, RR; Gruis, NA; Hurks, MHMH; Jager, MJ; Krijgsman, E; Ksander, BR; Pavey, S; Tensen, CP; van der Velden, PA; Willemze, R; Zuidervaart, W | 1 |
| Gołab, J; Jakóbisiak, M; Kamiński, R; Kozar, K; Lasek, W; Machaj, E; Mackiewicz, A; Ołdak, T; Switaj, T; Wysocki, PJ | 1 |
| Guan, X; Koganehira, Y; Oguchi, M; Sagara, J; Saida, T; Taniguchi, S; Yokoyama, T | 1 |
| Heng, HH; Iwata, J; Liang, SB; Ohtsuki, Y; Sonobe, H; Takeuchi, T; Ye, CJ | 1 |
| Grossman, D; Hanks, AN; Jones, DA; Karpf, AR; Lasek, AW; Ririe, TO | 1 |
| Blaschke, B; Knobbe, CB; Reifenberger, G; Reifenberger, J; Ruzicka, T; Schulte, KW; Sterzinger, AA | 1 |
| Akasaka, T; Maesawa, C; Masuda, T; Wada, K | 1 |
| Golab, J; Grzela, T; Jakobisiak, M; Kaminski, R; Koronkiewicz, M; Kozar, K; Niderla, J; Skierski, JS; Wilczynski, G | 1 |
| Altomonte, M; Colizzi, F; Coral, S; Danielli, R; Fonsatti, E; Fratta, E; Maio, M; Sigalotti, L; Tanzarella, S; Traversari, C | 1 |
| Furuta, J; Kaneda, A; Otsuka, F; Sugimura, T; Umebayashi, Y; Ushijima, T | 1 |
| Hoon, DS; Huang, S; Kim, J; Koyanagi, K; Mori, T; Takeuchi, H; Umetani, N; Yamano, T | 1 |
| Chang, CC; Ferrone, S; Lin, AF; Yan, WH | 1 |
| Ferrone, S; Kageshita, T; Karpf, AR; Luo, W; Wakasugi, S; Wang, X | 1 |
| Jager, M; Ono, SJ; Radosevich, M | 1 |
| Hoon, DS; Kitago, M; Martinez, SR; Mori, T; Morton, DL; Nguyen, SL; O'Day, SJ; Tanemura, A; Tran, AN; Umetani, N; Wang, HJ | 1 |
| Dressman, HK; Gollob, JA; Issa, JP; Jelinek, J; Moran, K; Peterson, BL; Richmond, T; Sciambi, CJ; Thoreson, M | 1 |
| Bosenberg, M; Bradbury, CM; Curley, DP; Duraisamy, S; Hobbs, C; Muthusamy, V; Nelson, B | 1 |
| Bandle, R; Clair, T; Koh, E; Roberts, DD; Stracke, ML | 1 |
| Bazhin, AV; Eichmüller, SB; Schadendorf, D; Schnölzer, M; Wiedemann, N | 1 |
| Coral, S; Covre, A; Maio, M; Natali, PG; Nicolay, HJ; Sigalotti, L | 1 |
| Furuta, J; Kikuchi, K; Miyagi, Y; Nakagawa, H; Nakanishi, Y; Nobeyama, Y; Okochi-Takada, E; Ushijima, T; Yamamoto, A | 1 |
| Altomonte, M; Calabrò, L; Colizzi, F; Fonsatti, E; Guidoboni, M; Maio, M; Marincola, FM; Nicolay, HJ; Pezzani, L; Sigalotti, L | 1 |
| Bae, SI; Borden, EC; Cheriyath, V; Jacobs, BS; Reu, FJ | 1 |
| Gollob, JA; Sciambi, CJ | 1 |
| Brasseur, F; De Plaen, E; De Smet, C; Kholmanskikh, O; Loriot, A | 1 |
| Coppock, DL; Straus, DS | 1 |
| Herlyn, M; Johnson, B; Lassam, N; Rosenberg, SA; Salgaller, M; Samid, D; Treisman, J; Weber, J | 1 |
| Creagan, ET; Hartmann, LC; Loprinzi, CL; Schaid, DJ | 1 |
| Boon, T; Brasseur, F; De Backer, O; De Smet, C; Faraoni, I; Lurquin, C | 1 |
| Carrel, S; Cerottini, JC; Rimoldi, D; Schreyer, M; Spagnoli, G | 1 |
| Boon, T; De Plaen, E; De Smet, C; Naerhuyzen, B; Szikora, JP | 1 |
| Chen, PW; Ksander, BR; Murray, TG; Reddy, R; Salgaller, ML; Uno, T | 1 |
| Altomonte, M; Cattarossi, I; Cattelan, A; Coral, S; Gasparollo, A; Maio, M; Sigalotti, L; Visintin, A | 1 |
| Arden, KC; Boon, T; Boretti, M; Brasseur, F; Chomez, P; Czekay, S; De Backer, O; De Plaen, E; De Smet, C; Van den Eynde, B; van der Bruggen, P; Vantomme, V; Viars, CS | 1 |
| Adema, GJ; de Bruijn, DR; de Vries, TJ; dos Santos, NR; Kater-Baats, E; Ruiter, DJ; Schreurs, MW; Torensma, R; van Kessel, AG; van Muijen, GN | 1 |
| Chen, GA; Fischette, MR; Guo, ZS; Hong, JA; Nguyen, DM; Ohnmacht, GA; Schrump, DS; Weiser, TS | 1 |
| Altomonte, M; Cattarossi, I; Ciullo, M; Coral, S; Gasparollo, A; Guardiola, J; Maio, M; Prisco, A; Sigalotti, L | 1 |
| Christmann, M; Kaina, B; Lage, H; Pick, M; Schadendorf, D | 1 |
| Bergman, W; Frants, RR; Gruis, NA; Hurks, H; Jager, MJ; Metzelaar-Blok, JA; Monique, H; van der Velden, PA | 1 |
| Gorelik, E; Huang, X; Li, M; Orucevic, A | 1 |
| Garrido, F; Lionello, I; Mendez, R; Ruiz-Cabello, F; Serrano, A; Tanzarella, S; Traversari, C | 1 |
| den Hollander, AI; Ruiter, DJ; van Kraats, AA; van Muijen, GN; Weidle, UH; Zendman, AJ | 1 |
| Biesta, P; Quinten, E; van den Elsen, PJ; van der Stoep, N | 1 |
| Bellet, RE; Berd, D; Catalano, RB; Mastrangelo, MJ | 1 |
| Bellet, RE; Berd, D; Danna, V; Mastrangelo, MJ | 1 |
| Abbruzzese, JL; Frost, P | 1 |
| Grant, JH; Kudlow, JE; Meluch, AA; Paterson, AJ; Shin, TH | 1 |
| Parsons, PG; Takahashi, H | 1 |
| Gorelik, E; Herberman, RB; Overton, R; Peppoloni, S | 1 |
| Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL | 1 |
| Everett, CA; Hart, IR; Ormerod, EJ | 1 |
| Everett, CA; Finch, M; Hart, IR; Ormerod, EJ | 1 |
| Bernheim, J; Buyssens, N; Cortvrindt, R; Roobol, K | 1 |
| Abele, R; Bruntsch, U; Clavel, M; Dodion, P; Gundersen, S; Pinedo, HM; Renard, J; Smyth, J; van Glabbeke, M | 1 |
| Barbieri, R; Fisher, PB; Gambari, R; Giacomini, P; Natali, PG; Piva, R; Tecce, R | 1 |
1 review(s) available for azacitidine and Malignant Melanoma
| Article | Year |
|---|---|
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.
Topics: Azacitidine; Biomarkers, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Melanoma; MicroRNAs; Prognosis | 2017 |
7 trial(s) available for azacitidine and Malignant Melanoma
| Article | Year |
|---|---|
Guadecitabine Plus Ipilimumab in Unresectable Melanoma: The NIBIT-M4 Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; CD8-Positive T-Lymphocytes; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Ipilimumab; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Patient Safety; Programmed Cell Death 1 Receptor; Survival Rate; Treatment Outcome | 2019 |
A phase I study of decitabine with pegylated interferon α-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA Methylation; Female; Humans; Interferon alpha-2; Interferon-alpha; Leukocyte Count; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Neutropenia; Polyethylene Glycols; Recombinant Proteins; T-Lymphocyte Subsets | 2014 |
Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide).
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epigenomics; Eye Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Panobinostat; Skin Neoplasms; Temozolomide; Treatment Outcome | 2014 |
Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Dacarbazine; Decitabine; Disease-Free Survival; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Skin Neoplasms; Temozolomide | 2013 |
Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Renal Cell; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Fetal Hemoglobin; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Injections, Intravenous; Injections, Subcutaneous; Interleukin-2; Kidney Neoplasms; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Melanoma; Middle Aged; Predictive Value of Tests; Treatment Outcome | 2006 |
A phase II study of 5,6-dihydro-5-azacytidine hydrochloride in disseminated malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biopsy; Chest Pain; Female; Humans; Immunologic Factors; Infusions, Intravenous; Male; Melanoma; Middle Aged; Nausea; Remission Induction; Risk Factors; Severity of Illness Index; Survival Rate; Vomiting | 1993 |
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Clinical Trials as Topic; Decitabine; Female; Hematologic Diseases; Humans; Male; Melanoma; Middle Aged; Neoplasms | 1987 |
104 other study(ies) available for azacitidine and Malignant Melanoma
| Article | Year |
|---|---|
Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Hydrolysis; Leukemia L1210; Leukemia, Experimental; Melanoma; Mice; Neoplasms, Experimental | 1977 |
Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.
Topics: Azacitidine; Child, Preschool; GTP Phosphohydrolases; Humans; Male; Melanoma; Membrane Proteins; Meningeal Neoplasms; Mitogen-Activated Protein Kinase Kinases; Mutation; Nevus, Pigmented; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Skin Neoplasms | 2022 |
5‑Aza‑dC suppresses melanoma progression by inhibiting GAS5 hypermethylation.
Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mice; Mice, Nude; RNA, Long Noncoding | 2022 |
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
Topics: Animals; Azacitidine; Chemoradiotherapy; Disease Models, Animal; Drug Synergism; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Signal Transduction; Treatment Outcome | 2021 |
Tumor antigen PRAME is up-regulated by MZF1 in cooperation with DNA hypomethylation in melanoma cells.
Topics: Antigens, Neoplasm; Azacitidine; Binding Sites; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Kruppel-Like Transcription Factors; Melanoma; Promoter Regions, Genetic; Protein Binding; RNA Interference; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Transfection; Up-Regulation | 2017 |
Silencing of metallothionein 1A gene in melanoma.
Topics: 5' Untranslated Regions; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Child; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanocytes; Melanoma; Metallothionein; Middle Aged; Nevus, Pigmented; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Young Adult | 2017 |
Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carboplatin; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Damage; DNA Methylation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Promoter Regions, Genetic | 2018 |
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Topics: Antigen-Presenting Cells; Antigens, Neoplasm; Azacitidine; B-Lymphocytes; Cancer Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Melanoma; Neoplasms; RNA, Messenger; Telomerase; Telomere; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat | 2013 |
Potential role of 5-aza-2'-deoxycytidine induced MAGE-A4 expression in immunotherapy for anaplastic thyroid cancer.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression; Humans; Immunotherapy; Indoles; MAP Kinase Signaling System; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Sulfonamides; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2013 |
Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Female; Gene Regulatory Networks; Genes, Neoplasm; Humans; Melanoma; Signal Transduction; Transcription, Genetic; Up-Regulation | 2014 |
The demethylating agent 5-Aza reduces the growth, invasiveness, and clonogenicity of uveal and cutaneous melanoma.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colony-Forming Units Assay; Decitabine; DNA Modification Methylases; DNA, Neoplasm; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Neoplasms, Experimental; Skin Neoplasms; Uveal Neoplasms | 2014 |
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin | 2014 |
Epigenetic regulation of p14ARF and p16INK4A expression in cutaneous and uveal melanoma.
Topics: Adult; Azacitidine; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Humans; Melanoma; Promoter Regions, Genetic; Tumor Suppressor Protein p14ARF; Uveal Neoplasms | 2015 |
DNA methylation contributes toward silencing of antioncogenic microRNA-203 in human and canine melanoma cells.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cells, Cultured; DNA Methylation; Dog Diseases; Dogs; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Melanocytes; Melanoma; MicroRNAs; Mouth Neoplasms | 2015 |
Elucidating the immunological effects of 5-azacytidine treatment in patients with myelodysplastic syndrome and identifying new conditional ligands and T-cell epitopes of relevance in melanoma.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Epitopes, T-Lymphocyte; HLA-A Antigens; Humans; Immunologic Factors; Leukocytes, Mononuclear; Ligands; Melanoma; Myelodysplastic Syndromes; Nodal Protein; T-Lymphocytes; White People | 2015 |
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Colorectal Neoplasms; DNA Methylation; Female; Humans; Interferon Type I; Melanoma | 2015 |
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Topics: Animals; Azacitidine; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Endogenous Retroviruses; Female; Humans; Immunotherapy; Interferon Type I; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; RNA, Double-Stranded | 2015 |
A novel apoptosis-inducing mechanism of 5-aza-2'-deoxycitidine in melanoma cells: Demethylation of TNF-α and activation of FOXO1.
Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; DNA Methylation; Dogs; Forkhead Box Protein O1; Forkhead Transcription Factors; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Prognosis; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Silencing; Melanocytes; Melanoma; Mice; MicroRNAs; Promoter Regions, Genetic | 2015 |
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Transketolase; Up-Regulation | 2016 |
MAGE-C2-Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses.
Topics: Antigens, Neoplasm; Azacitidine; B7-1 Antigen; B7-2 Antigen; B7-H1 Antigen; Cell Line, Tumor; Epitopes, T-Lymphocyte; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Melanoma; Neoplasm Proteins; Receptors, Antigen, T-Cell; T-Lymphocytes; Valproic Acid | 2016 |
Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Child; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2016 |
Combining Type I Interferons and 5-Aza-2'-Deoxycitidine to Improve Anti-Tumor Response against Melanoma.
Topics: Analysis of Variance; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Interferon Type I; Melanoma; Mice; Mice, Inbred C57BL; Skin Neoplasms; Statistics, Nonparametric | 2017 |
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Melanoma; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Skin Neoplasms; Time Factors; Treatment Outcome; Up-Regulation; Uveal Neoplasms | 2017 |
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Dioxygenases; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Demethylation; DNA Methylation; DNA Methyltransferase 3A; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Small Interfering; Transforming Growth Factor beta1; Xenograft Model Antitumor Assays | 2017 |
Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.
Topics: Azacitidine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; Esophageal Neoplasms; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glioma; Heat-Shock Proteins; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Proteins; Microfilament Proteins; Neuropeptides; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
PAX4 has the potential to function as a tumor suppressor in human melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Methylation; DNA Replication; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Paired Box Transcription Factors; RNA, Messenger; Skin Neoplasms; Time Factors; Transfection; Tumor Suppressor Proteins | 2008 |
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Survival; Decitabine; DNA Methylation; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Focal Adhesions; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Melanoma; Phosphorylation; Promoter Regions, Genetic; rap1 GTP-Binding Proteins; Transfection | 2009 |
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications.
Topics: Apoptosis; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Computational Biology; Decitabine; DNA Damage; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Melanoma | 2009 |
14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence.
Topics: 14-3-3 Proteins; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cellular Senescence; CpG Islands; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Exonucleases; Exoribonucleases; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Neoplasm Metastasis; Neoplasm Proteins; Phenylbutyrates; RNA, Messenger | 2009 |
Expression and function of CD9 in melanoma cells.
Topics: Animals; Antigens, CD; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Infant, Newborn; Melanocytes; Melanoma; Membrane Glycoproteins; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetraspanin 29; Transfection | 2010 |
Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1.
Topics: Amino Acid Substitution; Animals; Azacitidine; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cell Differentiation; Cell Line, Tumor; CpG Islands; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; MAP Kinase Signaling System; Melanoma; Mice; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mutant Proteins; Neurons; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Response Elements; Transcription Factor HES-1; Transcription, Genetic | 2010 |
Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Endogenous Retroviruses; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Gene Silencing; Humans; Melanoma; Promoter Regions, Genetic; RNA Splicing; Sequence Analysis, RNA; Sulfites; Terminal Repeat Sequences; Viral Envelope Proteins | 2010 |
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Clone Cells; Cloning, Molecular; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Inheritance Patterns; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Genome, Human; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Tumor Suppressor Proteins; Up-Regulation | 2010 |
VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; MicroRNAs; Receptors, Calcitriol; Signal Transduction; Skin Neoplasms; Time Factors; Vitamin D | 2010 |
Functional modulation of IGF-binding protein-3 expression in melanoma.
Topics: Apoptosis; Azacitidine; Base Sequence; Caspase 3; Cell Division; Cell Line, Tumor; Cell Survival; Chromatin; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Melanoma; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms | 2010 |
Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Exons; Gene Expression Regulation, Neoplastic; Humans; Lung; Melanoma; Neoplasms; Promoter Regions, Genetic; Recoverin; Skin; Small Cell Lung Carcinoma | 2010 |
Interferon-alpha induces reversible DNA demethylation of the interferon-induced transmembrane protein-3 core promoter in human melanoma cells.
Topics: Azacitidine; Biomarkers, Pharmacological; Cell Growth Processes; Cell Line, Tumor; Chemotactic Factors; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Melanoma; Membrane Proteins; Promoter Regions, Genetic; RNA-Binding Proteins; S100 Proteins; Transforming Growth Factor beta; Transgenes | 2011 |
Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Proliferation; Comparative Genomic Hybridization; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomics; Humans; Male; Melanoma; Middle Aged; Oligonucleotide Array Sequence Analysis; Skin Neoplasms; Transfection | 2011 |
The Levels of H11/HspB8 DNA methylation in human melanoma tissues and xenografts are a critical molecular marker for 5-Aza-2'-deoxycytidine therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle; Decitabine; DNA Methylation; Female; Heat-Shock Proteins; Humans; Melanocytes; Melanoma; Mice; Mice, Inbred BALB C; Molecular Chaperones; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Xenograft Model Antitumor Assays | 2011 |
Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Division; Cell Proliferation; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; G2 Phase; Melanoma; Mice; Tumor Cells, Cultured | 2011 |
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cell Proliferation; Cells, Cultured; Epigenomics; Humans; Melanocytes; Melanoma; MicroRNAs; Real-Time Polymerase Chain Reaction; Receptors, Calcitriol; RNA, Messenger; Skin Neoplasms; Vitamin D | 2012 |
A semantic web framework to integrate cancer omics data with biological knowledge.
Topics: Azacitidine; Database Management Systems; Decitabine; Drug Resistance, Neoplasm; Epigenomics; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Humans; Internet; Melanoma; Semantics; Transcription Factors; Translational Research, Biomedical | 2012 |
5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cholesterol; Decitabine; Dipeptidyl Peptidase 4; DNA Methylation; Epigenesis, Genetic; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Neoplastic; Geranyltranstransferase; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Mass Spectrometry; Melanoma; Proteomics; RNA, Small Interfering | 2012 |
Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; MicroRNAs; Oligonucleotide Array Sequence Analysis; Skin; Skin Neoplasms; Up-Regulation | 2013 |
Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.
Topics: Animals; Azacitidine; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Hydroxamic Acids; Karyotyping; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Phenotype; Risk; Skin Neoplasms | 2012 |
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Cytotoxicity, Immunologic; DNA Methylation; Humans; Immunomodulation; Immunophenotyping; Immunotherapy; Melanoma; Neoplasms | 2013 |
Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis.
Topics: Animals; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Methylation; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2013 |
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatin Immunoprecipitation; DNA Methylation; Epithelial-Mesenchymal Transition; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Luciferases; Melanoma; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Point Mutation; Proto-Oncogene Proteins c-mdm2; Real-Time Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Transplantation, Heterologous; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
Expression spectrum and methylation-dependent regulation of melanoma antigen-encoding gene family members in pancreatic cancer cells.
Topics: Adult; Aged; Antigens, Neoplasm; Azacitidine; Culture Techniques; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression; Gene Expression Regulation; Humans; Male; Melanoma; Middle Aged; Pancreatic Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2002 |
Methylation-regulated expression of HLA class I antigens in melanoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Genes, MHC Class I; HLA Antigens; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; Tumor Cells, Cultured; Up-Regulation | 2003 |
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.
Topics: Azacitidine; Biomarkers, Tumor; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; DNA Probes; Down-Regulation; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoenzyme Techniques; Liver Neoplasms; Melanoma; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured; Uveal Neoplasms | 2003 |
Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; CD4 Antigens; CD8 Antigens; Cell Line, Tumor; Cell Survival; Decitabine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hemoglobins; Immunotherapy; Interferon-gamma; Interleukin-12; Interleukin-4; Lectins, C-Type; Lymph Nodes; Lymphocytes; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, SCID; Models, Genetic; Neutrophils; NK Cell Lectin-Like Receptor Subfamily B; Protein Biosynthesis; Proteins; Time Factors | 2003 |
ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma.
Topics: Apoptosis; Azacitidine; Blotting, Western; CARD Signaling Adaptor Proteins; Caspase 1; CpG Islands; Cytoskeletal Proteins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; DNA, Neoplasm; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanoma; Nevus, Pigmented; Polymerase Chain Reaction; Proteins; Skin Neoplasms; Sulfites; Tumor Cells, Cultured | 2003 |
Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.
Topics: Actins; Amino Acid Sequence; Azacitidine; Blotting, Northern; Blotting, Western; Cloning, Molecular; Decitabine; DNA, Complementary; Down-Regulation; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Melanoma; Microfilament Proteins; Molecular Sequence Data; Neoplasm Proteins; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Transfection; Tumor Cells, Cultured; Two-Hybrid System Techniques; Ubiquitin-Protein Ligases; Yeasts | 2003 |
Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Epithelial Cells; Gene Expression Regulation; Humans; Melanocytes; Melanoma; Melanoma-Specific Antigens; Multigene Family; Neoplasm Proteins; Transcriptional Activation | 2004 |
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2004 |
Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Serpins | 2004 |
Demethylating agent 5-aza-2'-deoxycytidine enhances expression of TNFRI and promotes TNF-mediated apoptosis in vitro and in vivo.
Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Separation; CpG Islands; Decitabine; DNA Fragmentation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Melanoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Recombinant Proteins; Ribonucleases; RNA; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; HLA-B Antigens; Humans; Melanoma; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms | 2004 |
Silencing of the thrombomodulin gene in human malignant melanoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Melanocytes; Melanoma; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms; Thrombomodulin | 2005 |
Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2005 |
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Calreticulin; Cell Line, Tumor; Choriocarcinoma; Decitabine; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Melanoma; Methylation; Promoter Regions, Genetic; Transcription, Genetic | 2005 |
Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.
Topics: Antigens, Neoplasm; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes; Melanoma; Promoter Regions, Genetic; Tumor Cells, Cultured | 2006 |
Inhibition of MHC class II gene expression in uveal melanoma cells is due to methylation of the CIITA gene or an upstream activator.
Topics: Azacitidine; Base Sequence; Blotting, Southern; Cell Line, Tumor; DNA Methylation; Eye; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genes, MHC Class II; HeLa Cells; Humans; Interferon-gamma; Melanoma; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Uveal Neoplasms | 2007 |
Estrogen receptor-alpha methylation predicts melanoma progression.
Topics: Age Factors; Azacitidine; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Sex Factors | 2006 |
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
Topics: Animals; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Male; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Syk Kinase; Transfection; Transplantation, Heterologous; Tumor Suppressor Proteins | 2006 |
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Hydroxamic Acids; Lysophospholipids; Melanoma; Nerve Tissue Proteins; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; RNA-Binding Proteins; RNA, Messenger; Sphingosine | 2007 |
Expression of GAGE family proteins in malignant melanoma.
Topics: Antigens, Neoplasm; Autoantibodies; Azacitidine; Cell Line, Tumor; Humans; Hydroxamic Acids; Immunohistochemistry; Melanoma; Neoplasm Proteins; Recombinant Proteins; Skin Neoplasms | 2007 |
5-AZA-2'-deoxycytidine in cancer immunotherapy: a mouse to man story.
Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Humans; Immunotherapy, Adoptive; Melanoma; Mice; Xenograft Model Antitumor Assays | 2007 |
Silencing of tissue factor pathway inhibitor-2 gene in malignant melanomas.
Topics: Azacitidine; Cell Line, Tumor; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation; Gene Silencing; Glycoproteins; Humans; Immunohistochemistry; Melanoma; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Ultraviolet Rays | 2007 |
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; gp100 Melanoma Antigen; Histocompatibility Antigens Class I; Humans; Immunotherapy; Interferon-gamma; Melanoma; Membrane Glycoproteins; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; T-Lymphocytes, Cytotoxic; Up-Regulation | 2007 |
Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL.
Topics: Apoptosis; Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Interferons; Melanoma; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2008 |
Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Chemotactic Factors; Decitabine; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Interferon-gamma; Melanoma; S100 Proteins; Tumor Cells, Cultured; Uveal Neoplasms | 2007 |
Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.
Topics: Antigens, Neoplasm; Azacitidine; Blotting, Western; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin Neoplasms; Transfection; Tumor Cells, Cultured | 2008 |
Growth control variant cell line having increased serum requirement and decreased response to platelet-derived growth factor: reversion by 5-azacytidine.
Topics: Animals; Azacitidine; Blood; Cell Division; Cell Line; Clone Cells; DNA; Fibroblasts; Genetic Variation; Hybrid Cells; Insulin; Melanoma; Mice; Platelet-Derived Growth Factor | 1984 |
Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Cell Line; Cytotoxicity, Immunologic; Decitabine; DNA Primers; Female; Gene Expression Regulation, Neoplastic; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Lymphocytes; Lymphocytes, Tumor-Infiltrating; Melanocytes; Melanoma; Melanoma-Specific Antigens; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured | 1994 |
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; Cross Reactions; Decitabine; Immunohistochemistry; Melanoma; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Recombinant Proteins; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Alternative promoters of gene MAGE4a.
Topics: Alternative Splicing; Amino Acid Sequence; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cloning, Molecular; Decitabine; DNA-Binding Proteins; DNA, Neoplasm; Exons; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Placenta; Promoter Regions, Genetic; Restriction Mapping; Rhabdomyosarcoma; RNA, Messenger; Sequence Analysis, DNA; Testis; Tumor Cells, Cultured | 1997 |
Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.
Topics: Antigens, Neoplasm; Azacitidine; Clone Cells; Decitabine; Disease Progression; Eye Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Melanoma-Specific Antigens; Neoplasm Metastasis; Neoplasm Proteins; Tumor Cells, Cultured | 1997 |
Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR).
Topics: Alleles; Antigens, Neoplasm; Azacitidine; Blotting, Western; CD58 Antigens; Decitabine; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Intercellular Adhesion Molecule-1; Melanoma; Melanoma-Specific Antigens; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Cells, Cultured; Up-Regulation | 1999 |
Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.
Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Chromosome Mapping; Cloning, Molecular; COS Cells; Decitabine; Exons; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Male; Melanoma; Molecular Sequence Data; Multigene Family; Neoplasm Proteins; Neoplasms; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Testis; Transcriptional Activation; Transfection; Tumor Cells, Cultured; X Chromosome | 1999 |
Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.
Topics: Adult; Antibodies, Monoclonal; Antibody Specificity; Azacitidine; Caco-2 Cells; Cell Nucleus; Child; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunohistochemistry; K562 Cells; Male; Melanoma; Microscopy, Fluorescence; Neoplasm Proteins; Recombinant Fusion Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sequence Deletion; Testis; Tumor Cells, Cultured | 2000 |
Induction of MAGE-3 expression in lung and esophageal cancer cells.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antigens, Neoplasm; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Depsipeptides; DNA Modification Methylases; Enzyme Inhibitors; Esophageal Neoplasms; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lung Neoplasms; Melanoma; Neoplasm Proteins; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; DNA, Complementary; Down-Regulation; Flow Cytometry; HLA-A Antigens; HLA-B Antigens; Humans; Interferon-gamma; Leukocytes, Mononuclear; Melanoma; Molecular Sequence Data; Neoplasms; Phenotype; Recombinant Proteins; Ribonucleases; RNA, Messenger; Sequence Homology, Nucleic Acid; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2001 |
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.
Topics: Antineoplastic Agents; Azacitidine; Blotting, Southern; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Reactivators; Gene Amplification; Gene Expression; Guanine; Humans; Melanoma; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Promoter Regions, Genetic; Tumor Cells, Cultured | 2001 |
Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Melanoma; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Uveal Neoplasms | 2001 |
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes.
Topics: Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, MHC Class I; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melanoma; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tumor Cells, Cultured; Up-Regulation | 2000 |
Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epitopes, T-Lymphocyte; Genes, MHC Class I; HLA-A Antigens; HLA-B Antigens; Humans; Melanoma; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2001 |
Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis.
Topics: Amino Acid Sequence; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Blotting, Northern; Chromosome Mapping; Cloning, Molecular; Decitabine; Disease Progression; DNA Modification Methylases; DNA Primers; DNA, Complementary; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma; Molecular Sequence Data; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testis; Transfection; Tumor Cells, Cultured | 2002 |
Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines.
Topics: Azacitidine; Burkitt Lymphoma; Carcinoma; Cell Differentiation; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, MHC Class II; Genes, Reporter; HLA-DR Antigens; Humans; Interferon-gamma; Melanoma; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Signal Transduction; Trans-Activators; Transfection; Tumor Cells, Cultured | 2002 |
Phase II study of subcutaneously administered 5-azacytidine (NSC-102816) in patients with metastatic malignant melanoma.
Topics: Azacitidine; Bone Marrow; Dacarbazine; Drug Evaluation; Drug Resistance; Female; Humans; Injections, Subcutaneous; Male; Melanoma; Neoplasm Metastasis; Vomiting | 1978 |
Evaluation of a "nude" mouse-human tumor panel as a predictive secondary screen for cancer chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carmustine; Dacarbazine; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance; Female; Humans; Male; Melanoma; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasms, Experimental | 1979 |
Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cisplatin; Decitabine; DNA, Neoplasm; Drug Resistance; Drug Synergism; Humans; Melanoma; Methylation; Mice; Sensitivity and Specificity; Tubercidin; Tumor Cells, Cultured | 1992 |
5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.
Topics: Azacitidine; Base Sequence; DNA; Gene Expression Regulation; Humans; Kinetics; Melanoma; Methylation; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression.
Topics: Antigens, Neoplasm; Azacitidine; Butyrates; Butyric Acid; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Dimethyl Sulfoxide; Dimethylformamide; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Melanins; Melanoma; Microscopy, Electron; Monophenol Monooxygenase; Organelles; Phenotype | 1990 |
Increase in H-2 antigen expression and immunogenicity of BL6 melanoma cells treated with N-methyl-N'-nitronitrosoguanidine.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cross Reactions; Female; H-2 Antigens; Histocompatibility Antigens; Major Histocompatibility Complex; Melanoma; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL | 1985 |
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1985 |
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation | 1986 |
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methylation; Mice; Neoplasm Metastasis | 1986 |
5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cells, Cultured; Cytidine; Decitabine; Drug Resistance; Melanoma; Mice; Mutation; Uridine | 1987 |
Regulation of the expression of class II genes of the human major histocompatibility complex in tumor cells.
Topics: Azacitidine; B-Lymphocytes; DNA, Neoplasm; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Interferons; Leukemia, Erythroblastic, Acute; Major Histocompatibility Complex; Melanoma; Methylation; Recombinant Proteins; Tumor Cells, Cultured | 1987 |