azacitidine has been researched along with Leucocythaemia in 128 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (34.38) | 18.7374 |
1990's | 9 (7.03) | 18.2507 |
2000's | 33 (25.78) | 29.6817 |
2010's | 32 (25.00) | 24.3611 |
2020's | 10 (7.81) | 2.80 |
Authors | Studies |
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Bauer, K; Berger, D; Bettelheim, P; Gamperl, S; Greiner, G; Hoermann, G; Knöbl, P; Kornauth, C; Schiefer, AI; Schwarzinger, I; Sillaber, C; Smiljkovic, D; Sperr, WR; Staber, PB; Stefanzl, G; Thalhammer, R; Valent, P | 1 |
Barthélémy, A; Cheok, MH; Gonzales, F; Guilmatre, A; Lapillonne, H; Leverger, G; Petit, A; Pottier, N | 1 |
Georgieva, SG; Ilyin, YV; Kotnova, AP; Pankratova, EV; Stepchenko, AG | 1 |
Berthon, C; Carpentier, B; Chauvet, P; Goursaud, L; Lionne-Huyghe, P; Nibourel, O; Quesnel, B; Wemeau, M | 1 |
Bazinet, A; Bhalla, K; Borthakur, G; Curry, JL; Daver, N; Heberton, M; Kadia, T; Khoury, JD; Kim, K; Konopleva, M; Loghavi, S; Miller, D; Pemmaraju, N; Pierce, S; Wilson, NR | 1 |
Ciernikova, S; Fridrichova, I; Kalinkova, L; Sevcikova, A; Stevurkova, V | 1 |
Akhmetzhanova, S; Baidurin, S; Ilmalieva, A; Orazbekova, A; Sagyndykova, G | 1 |
Chung, P; Diorio, C; Niswander, LM; Tasian, SK | 1 |
Haiyan, C; Jie, W; Jing, L; Jun, L; Junxia, L; Ling, L; Ming, G; Xiaoqing, D | 1 |
Ma, J; Morimoto, K; Parekh, C; Pulsipher, MA | 1 |
Chen, Q; Gu, J; Li, N; Li, S; Wang, W; Wang, X; Wang, Z; Zhao, G | 1 |
Li, JJ; Liu, J; Wang, FJ; Xie, HT; Zeng, YY; Zhang, J | 1 |
Aoki, S; Fuse, K; Katagiri, T; Masuko, M; Miyakoshi, S; Shibasaki, Y; Sone, H; Takizawa, J; Tanaka, T; Ushiki, T | 1 |
Burkett, S; Cam, MC; Cunningham, T; Jailwala, P; Müller, F; Pastan, I; Stetler Stevenson, M; Stookey, S; Tai, CH; Wayne, AS | 1 |
Hals, PA; Hascher, A; Hummel-Eisenbeiss, J; Lyko, F; Müller-Tidow, C; Rius, M; Sandvold, ML | 1 |
Alp, E; Konac, E; Menevse, S; Yilmaz, A | 1 |
Brodská, B; Holoubek, A; Kuželová, K; Otevřelová, P | 1 |
Fandy, TE; Gore, SD; Jiemjit, A; Rhoden, P; Suarez, L; Thakar, M | 1 |
Billi, M; Binaglia, L; Ceccarelli, V; Grignani, F; Nocentini, G; Racanicchi, S; Riccardi, C; Roberti, R; Vecchini, A | 1 |
Brandwein, J; Del Bel, R; Gupta, V; Minden, MD; Schimmer, AD; Schuh, AC; Xu, W; Yee, KW | 1 |
Atanackovic, D; Badbaran, A; Binder, TM; Fehse, B; Hildebrandt, Y; Kröger, N; Luetkens, T; Stübig, T | 1 |
Hu, C; Jin, J; Li, K; Mei, C; Ren, Z; Tong, H; Vera, JC; Zhuang, Z | 1 |
Bacigalupo, A; Bregante, S; Colombo, N; Di Grazia, C; Dominietto, A; Galaverna, F; Geroldi, S; Ghiso, A; Grasso, R; Gualandi, F; Lamparelli, T; Luchetti, S; Raiola, AM; Stasia, A; Van Lint, MT; Varaldo, R | 1 |
Li, YH; Luo, JM; Meng, Z; Wang, DM | 1 |
Cao, L; Chai, Y; Gu, G; Hu, S; Pan, J; Wang, N; Zhao, W | 1 |
Arimondo, PB; Besse, J; Bréand, S; Busato, F; Cussac, D; Davoine, E; De Vries, L; Deroide, A; Desjobert, C; Fournier, L; Lestienne, F; Novosad, N; Riond, J; Tost, J; Vispé, S | 1 |
Imanishi, S; Ohsuga, M; Ohyashiki, JH; Ohyashiki, K; Takahashi, R | 1 |
Guan, RT; Guo, JX; Pan, JX; Zhang, XY; Zhong, JF; Zhou, YH | 1 |
Itano, Y; Kondo, T; Okamoto, S; Ouchida, M; Suemori, S; Takahashi, K; Tohyama, K; Tohyama, Y; Tsujioka, T; Yokoi, A | 1 |
Aul, C; Baron, F; Becker, H; Bogatyreva, L; de Witte, T; Ganser, A; Germing, U; Giagounidis, A; Hagemeijer, A; Huls, G; Labar, B; Lübbert, M; Marie, JP; Muus, P; Pflüger, KH; Platzbecker, U; Rüter, B; Salih, HR; Schaefer, HE; Selleslag, D; Suciu, S; van der Helm, L; Vellenga, E; Wijermans, PW | 1 |
Berulava, G; Khazal, S; Mahadeo, KM; Polishchuk, V; Roth, M | 1 |
Chen, J; Chen, SX; Huang, HT; Li, JG; Li, Q; Peng, Q; She, MR; Wei, SS; Xia, PF | 1 |
Guo, G; Jing, YK; Li, G; Liu, D; Liu, Y; Yang, QJ; Zhao, LX | 1 |
Fu, WL; Huang, Q; Yao, J; Zhang, XB | 1 |
Assaraf, YG; Bram, EE; Gonen, N | 1 |
Bandzuchová, E; Kuba, D; Poláková, K; Russ, G | 1 |
Garcia-Manero, G | 1 |
Garcia-Manero, G; Jain, N; Rossi, A | 1 |
Charbonneau, M; Momparler, LF; Momparler, RL; Raynal, NJ | 1 |
Dear, AE; Duong, J; Gumiero, D; Liu, HB; McKendrick, JJ; Voso, MT | 1 |
Champlin, R; de Lima, M; de Padua, L; Garcia-Manero, G; Giralt, S; Jabbour, E; Jagasia, M; Kantarjian, H; Kebriaei, P; Shpall, EJ | 1 |
Cai, Y; Gao, X; Gu, SZ; Liu, L; Liu, ZJ; Wang, G; Zhang, XB | 1 |
Arts, J; Fang, Z; Garcia-Manero, G; Kuang, SQ; Stevenson, W; Tong, WG; Wei, Y; Zhang, M | 1 |
Jiang, J; Liu, XS; Peng, CY; Zheng, HT | 1 |
Dear, AE; Liu, HB; Mayes, PA; McKendrick, JJ; Perlmutter, P | 1 |
Bártová, E; Jugová, A; Kozubek, S; Legartová, S; Stixová, L; Sustáčková, G | 1 |
Fan, LP; Fu, HY; Shen, JZ; Wu, DS; Xu, CB; Zhou, HR | 1 |
Ahuja, N; Baylin, SB; Beaty, R; Brock, MV; Cai, Y; Feller-Kopman, D; Harbom, KM; Harris, J; Issa, JP; Jang, YY; Li, H; Lin, YC; Matsui, W; Minn, I; Pappou, E; Rassool, FV; Robert, C; Sharkis, SJ; Shin, JJ; Stearns, V; Tsai, HC; Van Neste, L; Welm, AL; Yarmus, LB; Yen, RW; Zahnow, CA | 1 |
Chiao, JW; Hong, L; Huang, Y; Ma, X; Zou, Y | 1 |
Choi, YH; Han, MH; Kang, HS; Kim, GY; Kim, WJ; Park, YS; Shin, DY; Yang, K | 1 |
Hanaoka, N; Kurimoto, M; Matsuoka, H; Murayama, T; Nakakuma, H; Sonoki, T; Uneda, S | 1 |
Eisenhofer, G; Hagelgans, A; Lehnert, R; Menschikowski, M; Platzbecker, U; Schönefeldt, C; Siegert, G; Thiede, C; Vogel, M | 1 |
Chen, H; Du, H; Ren, L; Shi, Y; Wu, S; Zhu, Q | 1 |
Bertoni, F; Cotter, FE; Fu, WN; Jia, L; Kelsey, SM; McElwaine, SM; Newland, AC | 1 |
Andersson, B; Champlin, R; Couriel, D; de Lima, M; Donato, M; Gajewski, J; Giralt, S; Kantarjian, H; Khouri, I; Ravandi, F; Shahjahan, M; van Besien, K | 1 |
Barge, RM; Honders, MW; Spoelder, HE; Veuger, MJ; Willemze, R | 1 |
VESELY, J | 1 |
Bayar, E; Cortes, J; Faderl, S; Garcia-Manero, G; Giles, FJ; Issa, JP; Kantarjian, HM; Lyons, J; Mannari, R; Rosenfeld, CS; Thomas, D | 1 |
Garcia-Manero, G; Giles, FJ; Hennessy, BT; Kantarjian, HM | 1 |
Bernstein, M; Farinha, NJ; Lemaire, M; Momparler, LF; Momparler, RL | 1 |
Drach, J; Feng, Z; Gazdar, AF; Kroft, SH; McKenna, RW; Miyajima, K; Parikh, G; Reddy, J; Shigematsu, H; Shivapurkar, N; Suzuki, M; Takahashi, T; Timmons, C; Toyooka, S; Zheng, Y; Zöchbauer-Müller, S | 1 |
Byrd, JC; Issa, JP | 1 |
Momparler, RL | 1 |
Fenaux, P | 1 |
Lübert, M; Wijermans, P | 1 |
Bueso-Ramos, C; Cortes, J; Estey, E; Estrov, Z; Faderl, S; Fiorentino, J; Garcia-Manero, G; Issa, JP; Jabbour, E; Kantarjian, HM; Koller, C; O'brien, S; Ravandi, F; Rosner, G; Rytting, M; Sanchez-Gonzalez, B; Verstovsek, S; Wierda, WG; Xiao, L; Yang, H | 1 |
Cui, X; Liu, T; Meng, WT; Xi, YM; Ye, XS | 1 |
Boklan, J; Chandra, J; Gao, S; Miller, C; Mobley, A | 1 |
Ai, GW; Liu, W; Ma, XX; Meng, XQ; Meng, YS; Wei, R; Zhang, YX | 1 |
Baehner, RL; Bernstein, ID; Chard, RL; Hammond, D; Higgins, G; McCreadie, S; Sather, H | 1 |
Kessel, D; Khilanani, P; Lomen, PL | 1 |
Bloomfield, CD; Collins, AJ; Peterson, BA; Vogelzang, NJ | 1 |
Amare, M; Bodey, GP; Hewlett, JS; Linman, JW; Morrison, FS; Saiki, JH; Wilson, HE | 1 |
Chiuten, DF; Markus, S; Van Echo, DA; Wiernik, PH | 1 |
Benoit, P; Demers, J; Lin, K; Momparler, LF; Momparler, RL; Raymond, R; Rivard, GE | 1 |
Bloomfield, CD; Coleman, M; Gottlieb, AJ; Greenberg, MS; Peterson, BA | 1 |
Dahl, GV; Look, AT; Mauer, AM; Rivera, G | 1 |
Case, DC | 1 |
Chard, RL | 1 |
Bowman, WP; Dahl, GV; Evans, WE; Kalwinsky, D; Look, AT; Rivera, G | 1 |
Carella, AM; Marmont, AM; Santini, G | 1 |
Brodsky, I; Bulova, S; Conroy, JF; Kahn, SB; Lebedda, J; Sklaroff, R | 1 |
Gahrton, G | 1 |
Bouchard, J; Momparler, RL; Onetto, N; Rivard, GE | 1 |
Amelotti, F; Barbieri, R; Bernardi, F; del Senno, L; Gambari, R | 1 |
Gambari, R | 1 |
Amelotti, F; Barbieri, R; Bernardi, F; Conconi, F; del Senno, L; Gambari, R; Piva, R; Viola, L | 1 |
Avramis, VI; Kees, UR | 1 |
Jakubowski, A; Kritz, AD; Maslak, P; Menendez-Botet, C; Raptis, G | 1 |
Côté, S; Eliopoulos, N; Momparler, RL | 2 |
Champlin, R; Davis, M; de Vos, D; Giralt, S; Kantarjian, H; O'Brien, S; van Besien, K | 1 |
Gaestel, M; Neininger, A | 1 |
Baylin, SB; Herman, JG; Katzenellenbogen, RA | 1 |
Lübbert, M | 1 |
Hayashi, Y; Honma, Y; Niitsu, N; Sugita, K | 1 |
Anderlini, P; Andersson, B; Champlin, R; Claxton, D; Cohen, A; Davis, M; deVos, D; Donato, M; Gajewski, J; Giralt, S; Kantarjian, H; Khouri, I; Korbling, M; O'Brien, S; Ravandi, F; Ueno, N | 1 |
Beauséjour, CM; Eliopoulos, N; Le, NL; Momparler, L; Momparler, RL | 1 |
Giles, FJ | 1 |
Cihák, A; Veselý, J | 1 |
Comelli, A; Massimo, L | 1 |
Chabner, BA; Coleman, CN; Drake, JC; Stoller, RG | 1 |
Goldstein, JH; Israili, ZH; Mingioli, ES; Pirkle, JL; Smithwick, RW; Vogler, WR | 1 |
Levi, JA; Wiernik, PH | 1 |
Chabner, BA; Chang, P; Coleman, CN; Hande, KR; Stoller, RG | 1 |
Wiernik, PH | 1 |
Omura, GA | 1 |
Armitage, JO; Burns, CP | 1 |
Costanzi, JJ; Hewlett, JS; Hoogstraten, B; McCredie, KB; Morrison, FS; Saiki, JH; Stuckey, WJ; Vietti, TJ; Whitecar, J | 1 |
Cadman, E; Davis, L; Eiferman, F; Heimer, R | 1 |
Momparler, LF; Momparler, RL; Onetto-Pothier, N | 1 |
Colly, LP; Kluin-Nelemans, JC; Richel, DJ; Willemze, R | 1 |
Bourgeois, S; Harmon, JM; Smith, JR; Thompson, EB | 1 |
Lampkin, BC | 1 |
Lin, KT; Momparler, RL; Rivard, GE | 1 |
Moriconi, WJ; Slavik, M; Taylor, S | 1 |
Kissinger, LD; Stemm, NL | 1 |
Dahl, GV; Jackson, CW; Kalwinsky, DK; Look, AT; Mirro, J | 1 |
Gyger, M; Momparler, RL; Rivard, GE | 1 |
Glick, JH; Kahn, SB; Knospe, WH; Soojian, M; Spiers, A | 1 |
Castleberry, R; Hakami, N; Harris, R; Krischer, J; Look, AT; Ravindranath, Y; Steuber, PC; Vietti, TJ | 1 |
Glover, AB; Leyland-Jones, B | 1 |
Arlin, Z; Baker, M; Bhalla, K; Cole, J; Graham, G; Grant, S; MacLaughlin, W | 1 |
Chen, E; Ginder, GD; Karr, RW | 1 |
Avramis, VI; Mecum, RA; Powell, WC | 2 |
21 review(s) available for azacitidine and Leucocythaemia
Article | Year |
---|---|
Targeting DNA Methylation in Leukemia, Myelodysplastic Syndrome, and Lymphoma: A Potential Diagnostic, Prognostic, and Therapeutic Tool.
Topics: Azacitidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Leukemia; Lymphoma; Myelodysplastic Syndromes; Prognosis | 2022 |
MYELODYSPLASTIC SYNDROME: DIAGNOSIS, TREATMENT AND PROGNOSIS (LITERATURE REVIEW).
Topics: Azacitidine; Humans; Leukemia; Myelodysplastic Syndromes; Prognosis; Quality of Life | 2023 |
Venetoclax and Azacitidine in the Treatment of
Topics: Azacitidine; Fanconi Anemia; Humans; Leukemia; Nuclear Proteins | 2023 |
Successful 5-azacytidine treatment of myeloid sarcoma and leukemia cutis associated with myelodysplastic syndrome: A case report and literature review.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Diagnosis, Differential; Female; Humans; Leukemia; Myelodysplastic Syndromes; Sarcoma, Myeloid | 2017 |
Demethylating agents in myeloid malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Trials as Topic; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Humans; Leukemia; Myelodysplastic Syndromes; Risk; Treatment Outcome; Valproic Acid | 2008 |
Epigenetic therapy of leukemia: An update.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia; Neoplasms | 2009 |
Decitabine: 2'-deoxy-5-azacytidine, Aza dC, DAC, dezocitidine, NSC 127716.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Differentiation; Clinical Trials as Topic; Decitabine; DNA Methylation; Drugs, Investigational; Gene Expression Regulation; Humans; Leukemia; Transcriptional Activation | 2003 |
Decitabine: 2'-deoxy-5-azacytidine, Aza dC, DAC, dezocitidine, NSC 127716.
Topics: Anemia, Sickle Cell; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Decitabine; Humans; Leukemia; Lung Neoplasms; Male; Prostatic Neoplasms | 2003 |
DNA methylation in haematological malignancies: the role of decitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Decitabine; DNA Methylation; Hematologic Neoplasms; Humans; Leukemia | 2003 |
Decitabine in chronic leukemias.
Topics: Azacitidine; Chronic Disease; Combined Modality Therapy; Decitabine; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive | 2005 |
Pharmacology of 5-Aza-2'-deoxycytidine (decitabine).
Topics: Animals; Azacitidine; Biotransformation; Decitabine; Humans; Leukemia; Treatment Outcome | 2005 |
Inhibitors of DNA methylation: beyond myelodysplastic syndromes.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA Modification Methylases; Hematologic Neoplasms; Humans; Leukemia | 2005 |
Epigenetic therapy with decitabine for myelodysplasia and leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Decitabine; DNA Methylation; Epigenesis, Genetic; Humans; Leukemia; Myelodysplastic Syndromes | 2005 |
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinones; Antibodies, Monoclonal; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Immunotherapy; Infant; Interferons; Leukemia; Leukemia, Lymphoid; Liposomes; Middle Aged; Mitoxantrone; Naphthacenes; Prognosis; Teniposide; Transplantation, Homologous; Transplantation, Isogeneic; Vinblastine; Vindesine | 1983 |
Pharmacological approach for optimization of the dose schedule of 5-Aza-2'-deoxycytidine (Decitabine) for the therapy of leukemia.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Diseases; Cell Differentiation; Decitabine; Deoxycytidine Kinase; DNA Methylation; DNA, Neoplasm; Drug Administration Schedule; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Genes, Tumor Suppressor; Hematopoiesis; Humans; Leukemia | 1997 |
Pharmacological approach for optimization of the dose schedule of 5-Aza-2'-deoxycytidine (Decitabine) for the therapy of leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Modification Methylases; Drug Administration Schedule; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Leukemia; Leukemia, Experimental | 1997 |
DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Decitabine; DNA Methylation; DNA Modification Methylases; Hemoglobinopathies; Humans; Leukemia; Myelodysplastic Syndromes | 2000 |
Novel agents for the therapy of acute leukemia.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Azacitidine; Cysteine Endopeptidases; Cytosine; Decitabine; Dioxolanes; DNA Methylation; Humans; Leukemia; Multienzyme Complexes; Neovascularization, Pathologic; Proteasome Endopeptidase Complex | 2002 |
Glucocorticoid receptors in human leukemias and related diseases.
Topics: Animals; Azacitidine; Cell Line; Cell Survival; Clone Cells; Decitabine; Dexamethasone; Drug Resistance; Glucocorticoids; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Mice; Mutation; Phenotype; Prognosis; Receptors, Glucocorticoid | 1985 |
Cell kinetics as related to treatment of patients with acute nonlymphoid leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Bone Marrow Cells; Cell Cycle; Child; Cytarabine; Daunorubicin; Doxorubicin; Etoposide; Flow Cytometry; Hematopoietic Stem Cells; Humans; Hydrocortisone; Leukemia; Methotrexate; Mitotic Index; Neoplastic Stem Cells; Prednisone; Prognosis; Vincristine | 1985 |
Biochemistry of azacitidine: a review.
Topics: Animals; Azacitidine; Biochemical Phenomena; Biochemistry; Cell Differentiation; DNA; Gene Expression Regulation; Humans; Leukemia; RNA; Transcriptional Activation | 1987 |
15 trial(s) available for azacitidine and Leucocythaemia
Article | Year |
---|---|
Decitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Disease Progression; Disease-Free Survival; Female; Germany; Humans; Leukemia; Male; Middle Aged; Monosomy; Myelodysplastic Syndromes; Risk Factors | 2016 |
Long-term follow-up of a phase I study of high-dose decitabine, busulfan, and cyclophosphamide plus allogeneic transplantation for the treatment of patients with leukemias.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Busulfan; Cyclophosphamide; Decitabine; Disease-Free Survival; Dose-Response Relationship, Drug; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Middle Aged; Survival Analysis; Transplantation Conditioning | 2003 |
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Cell Cycle Proteins; Cell Differentiation; Child; Child, Preschool; Cohort Studies; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Female; Gene Silencing; Hematologic Neoplasms; Humans; Karyotyping; Leukemia; Male; Methylation; Middle Aged; Myeloproliferative Disorders; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2004 |
Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia.
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Child; Child, Preschool; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Humans; Leukemia; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Survival Analysis; Valproic Acid | 2006 |
Contrasting benefits of two maintenance programs following identical induction in children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Cyclophosphamide; Cytarabine; Humans; Leukemia; Thioguanine; Vincristine | 1984 |
Phase I study using combination of hydroxyurea and 5-azacytidine (NSC-102816).
Topics: Adult; Aged; Azacitidine; Bone Marrow; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia; Middle Aged; Neoplasms; Time Factors | 1980 |
Studies with anthracyclines in pediatric acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Azacitidine; Child; Child, Preschool; Clinical Trials as Topic; Daunorubicin; Doxorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia; Male; Middle Aged; Naphthacenes; Random Allocation; Sex Factors | 1981 |
Pilot study of 5-azacytidine (5-AZA) and carboplatin (CBDCA) in patients with relapsed/refractory leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Female; Humans; Leukemia; Male; Middle Aged; Pilot Projects; Recurrence | 1996 |
Studies of decitabine with allogeneic progenitor cell transplantation.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Combined Modality Therapy; Decitabine; Drug Administration Schedule; Hematopoietic Stem Cell Transplantation; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Middle Aged; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pseudomonas Infections; Recurrence; Time Factors; Transplantation, Homologous | 1997 |
Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant: results of a phase I study.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Cohort Studies; Decitabine; Dose-Response Relationship, Drug; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Middle Aged; Recurrence; Remission Induction; Survival Analysis; Transplantation, Homologous; Treatment Outcome | 2001 |
A comparative clinical trial of 5-azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Azacitidine; Digestive System; Female; Fever; Guanazole; Humans; Infusions, Parenteral; Leukemia; Leukopenia; Male; Middle Aged; Remission, Spontaneous; Time Factors; Triazoles | 1976 |
Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia.
Topics: Acute Disease; Adult; Azacitidine; Clinical Trials as Topic; Deoxyguanosine; Deoxyribonucleosides; Drug Therapy, Combination; Humans; Leukemia; Thionucleosides; Time Factors | 1977 |
Treatment of refractory adult acute nonlymphoblastic leukemia with subcutaneous 5-azacytidine.
Topics: Adult; Aged; Azacitidine; Bone Marrow; Clinical Trials as Topic; Digestive System; Female; Humans; Injections, Subcutaneous; Leukemia; Male; Middle Aged; Pilot Projects; Skin | 1977 |
Induction failures in childhood acute nonlymphocytic leukemia: etoposide/5-azacytidine for cases refractory to daunorubicin/cytarabine.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Clinical Trials as Topic; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Leukemia; Male | 1986 |
Clinical trial on 5-aza-2'-deoxycytidine in patients with acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Azacitidine; Cell Cycle; Cell Differentiation; Child; Clinical Trials as Topic; Decitabine; DNA, Neoplasm; Drug Evaluation; Humans; Leukemia; Methylation; Research Design | 1985 |
92 other study(ies) available for azacitidine and Leucocythaemia
Article | Year |
---|---|
Secondary basophilic leukemia in Ph-negative myeloid neoplasms: A distinct subset with poor prognosis.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Basophils; Female; Humans; Leukemia; Male; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms, Second Primary; Prognosis | 2021 |
Ex vivo drug sensitivity profiling-guided treatment of a relapsed pediatric mixed-phenotype acute leukemia with venetoclax and azacitidine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia; Leukemia, Myeloid, Acute; Phenotype; Sulfonamides | 2022 |
5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt's Lymphoma Cell Culture.
Topics: Animals; Azacitidine; Burkitt Lymphoma; Cell Culture Techniques; Leukemia; Mice; Octamer Transcription Factor-1; Protein Isoforms; RNA, Messenger; Tumor Cells, Cultured | 2022 |
Resurgence of myeloproliferative neoplasm in patients in remission from blast transformation after treatment with hypomethylating agents.
Topics: Azacitidine; Humans; Janus Kinase 2; Leukemia; Lymphocyte Activation; Mutation; Myeloproliferative Disorders; Neoplasms; Recurrence | 2022 |
Major clinical response in a patient with leukemia cutis treated with the bromodomain inhibitor PLX51107 and azacitidine.
Topics: Azacitidine; Humans; Leukemia; Leukemia, Myeloid, Acute; Oxazoles; Pyridines; Pyrroles; Skin Neoplasms | 2022 |
Clinical responses in pediatric patients with relapsed/refractory leukemia treated with azacitidine and venetoclax.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Child; Humans; Leukemia; Leukemia, Myeloid, Acute; Sulfonamides | 2023 |
Myelodysplastic Syndrome Treated by Integrated Chinese and Western Medicine: A Case Report.
Topics: Aged; Asian People; Azacitidine; China; Female; Humans; Leukemia; Male; Middle Aged; Myelodysplastic Syndromes; Programmed Cell Death 1 Receptor | 2023 |
Synergistic inhibitory effects of deferasirox in combination with decitabine on leukemia cell lines SKM-1, THP-1, and K-562.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Benzoates; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Decitabine; Deferasirox; Drug Synergism; Gene Expression Regulation; Humans; Iron Chelating Agents; Leukemia; Reactive Oxygen Species; Triazoles | 2017 |
[Effects of decitabine on proliferation capacity and TFPI-2 expression in leukemia K562 cells].
Topics: Apoptosis; Azacitidine; Cell Proliferation; Decitabine; Glycoproteins; Humans; K562 Cells; Leukemia | 2017 |
5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox.
Topics: Animals; Antineoplastic Agents; Azacitidine; Bacterial Toxins; Bone Marrow; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Exotoxins; Humans; Leukemia; Mice; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2018 |
The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Biological Transport; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Dogs; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Humans; Leukemia; Leukemia, Myeloid, Acute; Madin Darby Canine Kidney Cells | 2013 |
The DNA methyl transferase inhibitor, 5'-aza-2-deoxycitidine, enhances the apoptotic effect of Mevastatin in human leukemia HL-60 cells.
Topics: Apoptosis; Azacitidine; Caspases; Decitabine; DNA Modification Methylases; DNA Replication; Drug Synergism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; L-Lactate Dehydrogenase; Leukemia; Lovastatin; Methylation; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
Combined treatment with low concentrations of decitabine and SAHA causes cell death in leukemic cell lines but not in normal peripheral blood lymphocytes.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cells, Cultured; Decitabine; Dose-Response Relationship, Drug; Humans; Hydroxamic Acids; Leukemia; Lymphocytes; Vorinostat | 2013 |
Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes.
Topics: Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Azacitidine; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; Humans; Leukemia; Matrix Metalloproteinases; Oxidation-Reduction; Reactive Oxygen Species; Transcriptional Activation; Tumor Suppressor Protein p53 | 2014 |
Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells.
Topics: Azacitidine; Base Sequence; CCAAT-Enhancer-Binding Protein-delta; CpG Islands; DNA Methylation; Eicosapentaenoic Acid; Exons; Humans; Introns; Leukemia; MAP Kinase Signaling System; Membrane Microdomains; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins p21(ras); RNA Polymerase II; Transcription, Genetic; Tumor Suppressor Protein p53; U937 Cells | 2014 |
Salvage induction chemotherapy after azacitdine treatment failure in patients who received azacitidine as a bridge to allogeneic stem cell transplantation.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Drug Evaluation; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Kaplan-Meier Estimate; Leukemia; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Salvage Therapy; Treatment Failure; Young Adult | 2014 |
5-azacytidine promotes an inhibitory T-cell phenotype and impairs immune mediated antileukemic activity.
Topics: Antimetabolites, Antineoplastic; Azacitidine; CD8-Positive T-Lymphocytes; Cell Lineage; HL-60 Cells; Humans; Inflammation; K562 Cells; L-Lactate Dehydrogenase; Leukemia; Male; Middle Aged; Phenotype; Stem Cell Transplantation; T-Lymphocytes, Regulatory; Th1 Cells; Transplantation, Homologous | 2014 |
Sequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Nucleus; Cell Proliferation; Decitabine; Down-Regulation; Drug Synergism; Humans; Idarubicin; In Situ Nick-End Labeling; Leukemia; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Wnt Proteins | 2014 |
DLI after haploidentical BMT with post-transplant CY.
Topics: Adolescent; Adult; Aged; Allografts; Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Transplantation; Disease-Free Survival; Graft vs Host Disease; Hodgkin Disease; Humans; Leukemia; Living Donors; Lymphocyte Transfusion; Middle Aged; Recurrence; Survival Rate; Time Factors | 2015 |
[Effect of 5-aza-CdR demethylation on expression of SHP-1 and C-kit genes in leukemia HL-60 cells].
Topics: Azacitidine; DNA Methylation; HL-60 Cells; Humans; Leukemia; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-kit; RNA, Messenger | 2014 |
[Effect of DNA methylation on the proliferation of leukemia cells regulated by miR-34b].
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; HL-60 Cells; Humans; Leukemia; MicroRNAs; Polymerase Chain Reaction; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Transfection | 2014 |
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA-Binding Proteins; G2 Phase Cell Cycle Checkpoints; Histones; Humans; Leukemia; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Tumor Protein p73; Tumor Suppressor Proteins | 2015 |
Effect of combined deferasirox and 5-azacytidine treatment on human leukemia cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzoates; Deferasirox; HL-60 Cells; Humans; Iron Chelating Agents; Leukemia; Triazoles; U937 Cells | 2015 |
[Expression and Promoter CpG Island Methylation Status of miR-34b in Leukemia Cell Lines and Their Clinical Significance].
Topics: Azacitidine; Cell Proliferation; Child; CpG Islands; Decitabine; DNA Methylation; HL-60 Cells; Humans; K562 Cells; Leukemia; MicroRNAs; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Transfection | 2015 |
Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Cells; Cell Death; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Knockout Techniques; HL-60 Cells; Humans; Leukemia; Myelodysplastic Syndromes; Promoter Regions, Genetic; RNA, Small Interfering; Signal Transduction; Steroid Hydroxylases; Transcriptome | 2015 |
5-Azacitidine Monotherapy Followed by Related Haploidentical Hematopoietic Stem Cell Transplantation Achieves Durable Remission in a Pediatric Patient With Acute Undifferentiated Leukemia Refractory to High-Dose Chemotherapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Azacitidine; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Leukemia; Maintenance Chemotherapy; Male; Remission Induction; Transplantation, Homologous | 2016 |
[Decitabine Enhances the Sensitivity of Leukemia Stem Cell to Allo-NK Cell-Mediated Killing].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cytotoxicity, Immunologic; Decitabine; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Leukemia; Leukocytes, Mononuclear; NK Cell Lectin-Like Receptor Subfamily K; Stem Cells | 2017 |
Synthesis and antiproliferative activities of 5-azacytidine analogues in human leukemia cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Proliferation; Growth Inhibitors; HL-60 Cells; Humans; Leukemia | 2008 |
Promoter CpG methylation of oestrogen receptors in leukaemia.
Topics: Antibiotics, Antineoplastic; Azacitidine; Case-Control Studies; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; HL-60 Cells; Humans; Jurkat Cells; K562 Cells; Leukemia; Promoter Regions, Genetic; Receptors, Estrogen; RNA, Messenger; RNA, Neoplasm; U937 Cells | 2009 |
PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells.
Topics: Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression; Gene Expression Regulation, Leukemic; Gene Silencing; Humans; Leukemia; Membrane Transport Proteins; Promoter Regions, Genetic; Proton-Coupled Folate Transporter | 2008 |
Demethylating agent 5-aza-2'-deoxycytidine activates HLA-G expression in human leukemia cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Line, Tumor; Decitabine; Flow Cytometry; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Leukemia; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Synergistic effect of 5-Aza-2'-deoxycytidine and genistein in combination against leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cyclin-Dependent Kinase Inhibitor p57; Decitabine; DNA Methylation; DNA, Neoplasm; Drug Synergism; Genistein; HL-60 Cells; Humans; Leukemia; Leukemia L1210; Male; Mice; Promoter Regions, Genetic | 2008 |
The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cyclin-Dependent Kinase Inhibitor p15; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia; Matrix Metalloproteinase 9; Nuclear Receptor Subfamily 4, Group A, Member 1; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sulfonamides | 2009 |
Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia.
Topics: Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Combined Modality Therapy; Drug Administration Schedule; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Middle Aged; Recurrence; Retrospective Studies; Transplantation, Homologous | 2009 |
Androgen receptor CpG island methylation status in human leukemia cancer cells.
Topics: Adolescent; Adult; Azacitidine; Cell Line, Tumor; Child; CpG Islands; Decitabine; DNA Methylation; Female; Humans; Leukemia; Male; Middle Aged; Receptors, Androgen; RNA, Messenger | 2009 |
Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor.
Topics: Antineoplastic Agents; Azacitidine; Decitabine; Drug Evaluation, Preclinical; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia; Tumor Cells, Cultured | 2010 |
Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Drug Antagonism; Drug Synergism; Electrophoresis, Capillary; Growth Inhibitors; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; K562 Cells; Leukemia; Oxides; U937 Cells; Valproic Acid | 2010 |
The anti-leukemic effect and molecular mechanisms of novel hydroxamate and benzamide histone deacetylase inhibitors with 5-aza-cytidine.
Topics: Antineoplastic Agents; Azacitidine; Benzamides; Caspase 3; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia; Matrix Metalloproteinase 9; Nuclear Receptor Subfamily 4, Group A, Member 1 | 2011 |
Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells.
Topics: Antineoplastic Agents; Azacitidine; Chromobox Protein Homolog 5; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Leukemia; Multiple Myeloma; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2011 |
Methylation of secreted frizzled related protein gene in acute leukemia patients in China.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; China; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Enzyme Inhibitors; Eye Proteins; Female; Frizzled Receptors; Humans; Intercellular Signaling Peptides and Proteins; Jurkat Cells; Leukemia; Male; Membrane Proteins; Middle Aged; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Messenger; Wnt Signaling Pathway; Young Adult | 2011 |
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Bone Marrow Cells; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Damage; DNA Methylation; DNA Modification Methylases; Gene Silencing; Humans; Leukemia; Mice; Molecular Sequence Data; Neoplastic Stem Cells; Promoter Regions, Genetic; Signal Transduction; Tumor Cells, Cultured | 2012 |
Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia.
Topics: Acetylation; Acute Disease; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Case-Control Studies; Child; Decitabine; DNA Methylation; Female; Histone Deacetylase Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Isothiocyanates; Leukemia; Male; Middle Aged; Protein Processing, Post-Translational; Young Adult | 2012 |
Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.
Topics: Acetylcysteine; Apoptosis; Azacitidine; Baculoviral IAP Repeat-Containing 3 Protein; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Decitabine; Down-Regulation; Enzyme Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein | 2012 |
Pretreatment of leukemic cells with low-dose decitabine markedly enhances the cytotoxicity of gemtuzumab ozogamicin.
Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Decitabine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemtuzumab; Humans; Leukemia; Neoplasm Recurrence, Local; Tumor Cells, Cultured | 2013 |
Aberrant methylation of the M-type phospholipase A(2) receptor gene in leukemic cells.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Female; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Jurkat Cells; Leukemia; Male; Middle Aged; Myelodysplastic Syndromes; Receptors, Phospholipase A2; U937 Cells; Young Adult | 2012 |
[The re-expression of p15(INK4B) gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition].
Topics: Azacitidine; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression; Histone Deacetylase Inhibitors; Humans; In Vitro Techniques; Leukemia; Methyltransferases; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.
Topics: Apoptosis; Apoptotic Protease-Activating Factor 1; Azacitidine; Cytosine; Decitabine; DNA Methylation; Humans; Leukemia; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Reference Values; Sequence Analysis, DNA; Tumor Cells, Cultured; Ultraviolet Rays | 2003 |
Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines.
Topics: 2-Chloroadenosine; Alternative Splicing; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Biological Transport; Buthionine Sulfoximine; Calcium Channel Blockers; Cytarabine; Daunorubicin; Decitabine; Deoxyadenosines; Deoxycytidine Kinase; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Humans; Idarubicin; Leukemia; Methotrexate; Neoplasm Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Verapamil | 2003 |
THE EFFECT OF 6-AZAURIDINE AND 6-AZACYTIDINE ON THE INTRACELLULAR SYNTHESIS OF RNA IN FOWL LEUKEMIC AND NORMAL MYELOBLASTS IN VITRO.
Topics: Animals; Antimetabolites; Autoradiography; Azacitidine; Azauridine; Bone Marrow Examination; Cytoplasm; Granulocyte Precursor Cells; In Vitro Techniques; Leukemia; Leukemia, Experimental; Neoplasms, Experimental; Nucleosides; Poultry; Research; RNA; RNA, Neoplasm | 1964 |
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by phenylbutyrate on L1210 leukemic cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA; DNA Replication; Drug Synergism; Genes, Tumor Suppressor; HL-60 Cells; Humans; Leukemia; Male; Mice; Phenylbutyrates; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Suppressor Proteins | 2004 |
DNA methylation profiles of lymphoid and hematopoietic malignancies.
Topics: Age Factors; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Leukemia; Logistic Models; Lymphoma; Male; Middle Aged; Multiple Myeloma; Promoter Regions, Genetic; Sex Factors | 2004 |
[Methylation of P15INK4B gene in patients with myelodysplastic syndromes and demethylating effects of drugs].
Topics: Arsenic Trioxide; Arsenicals; Azacitidine; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; Disease Progression; DNA Methylation; Genetic Predisposition to Disease; Humans; Leukemia; Myelodysplastic Syndromes; Oxides | 2007 |
Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Benzamides; Biomarkers; Caspase 3; Drug Synergism; Enzyme Inhibitors; Glutathione; Histone Deacetylase Inhibitors; Histones; Humans; Jurkat Cells; Leukemia; Pyridines; Reactive Oxygen Species | 2008 |
[Epigenetic regulation of expression of retinoic acid receptor beta gene in leukemia cell].
Topics: Acetylation; Adult; Aged; Azacitidine; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Histones; Humans; Leukemia; Middle Aged; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tretinoin; U937 Cells; Valproic Acid | 2007 |
5-Azacytidine and renal tubular dysfunction.
Topics: Acute Disease; Adolescent; Adult; Aged; Azacitidine; Bicarbonates; Glycosuria; Humans; Kidney Tubules; Leukemia; Middle Aged; Phosphorus; Polyuria; Potassium; Sodium | 1981 |
Effect of schedule on activity and toxicity of 5-azacytidine in acute leukemia: a Southwest Oncology Group Study.
Topics: Acute Disease; Adult; Azacitidine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukemia; Male; Remission, Spontaneous; Time Factors | 1981 |
A clinical trial of pyrazofurin in combination with 5-azacytidine in acute adult nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Amides; Antibiotics, Antineoplastic; Azacitidine; Drug Evaluation; Female; Humans; Leukemia; Male; Middle Aged; Pyrazoles; Ribonucleosides; Ribose | 1981 |
Phase I study on 5-aza-2'-deoxycytidine in children with acute leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Cytarabine; Decitabine; Dose-Response Relationship, Drug; Drug Evaluation; Hematopoietic System; Humans; Leukemia; Male | 1981 |
5-azactidine and zorubicin for patients with previously treated acute nonlymphocytic leukemia: a Cancer and Leukemia Group B pilot study.
Topics: Acute Disease; Adult; Aged; Azacitidine; Bone Marrow; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Kidney; Leukemia; Liver; Male; Middle Aged; Pilot Projects | 1982 |
Clinical and cell kinetic studies of the effects of the epipodophyllotoxin VP16-213 during therapy of refractory acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Azacitidine; Cell Division; Child; Child, Preschool; DNA, Neoplasm; Drug Resistance; Etoposide; Female; Flow Cytometry; Humans; Infant; Kinetics; Leukemia; Male; Mitosis; Podophyllotoxin | 1982 |
5-azacytidine in refractory acute leukemia.
Topics: Acute Disease; Adult; Aged; Agranulocytosis; Azacitidine; Chemical and Drug Induced Liver Injury; Humans; Infusions, Parenteral; Leukemia; Leukemia, Myeloid; Middle Aged; Muscular Diseases | 1982 |
Single-agent and combination chemotherapy with etoposide in the acute leukemias of childhood.
Topics: Acute Disease; Azacitidine; Child; Drug Therapy, Combination; Etoposide; Humans; Leukemia; Podophyllotoxin; Prednisone; Vincristine | 1982 |
Amsacrine and 5-azacytidine in acute non lymphatic leukaemia (ANLL).
Topics: Acute Disease; Adult; Aminoacridines; Amsacrine; Azacitidine; Humans; Leukemia | 1982 |
4'-(9-acridinylamino)methane-sulfon-m-anisidide (m-AMSA) and 5-azacytidine (AZA) in the treatment of relapsed adult acute leukemia.
Topics: Acute Disease; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Agents; Azacitidine; Drug Therapy, Combination; Female; Humans; Leukemia; Male; Middle Aged; Prognosis; Recurrence | 1983 |
5-aza-2'-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation.
Topics: Azacitidine; Cell Line; Decitabine; DNA, Neoplasm; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methylation | 1984 |
Epsilon-globin gene is undermethylated in K-562 cells: increased expression after treatment of the cells with 5-azacytidine.
Topics: Azacitidine; Cell Line; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; DNA, Recombinant; Gene Expression Regulation; Globins; Humans; Leukemia; Methylation; Nucleic Acid Hybridization; RNA, Messenger | 1984 |
A monoclonal antibody to human transferrin receptor which inhibits erythroid differentiation of human leukemic K-562 cells.
Topics: Animals; Antibodies, Monoclonal; Azacitidine; Butyrates; Butyric Acid; Cell Differentiation; Cell Line; Electrophoresis, Cellulose Acetate; Erythroblasts; Hemin; Humans; Leukemia; Mice; Mice, Inbred BALB C; Receptors, Cell Surface; Receptors, Transferrin | 1984 |
Human leukemic K562 cells: differential effects of 5-azacytidine on DNA methylation of epsilon-, gamma-globin and 7SL RNA genes.
Topics: Azacitidine; Base Sequence; Cell Line; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Electrophoresis, Cellulose Acetate; Globins; Humans; Leukemia; Methylation; RNA | 1984 |
Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; DNA; Humans; Leukemia; Methylation; Tumor Cells, Cultured | 1995 |
Evidence for a hsp25-specific mechanism involved in transcriptional activation by heat shock.
Topics: Animals; Azacitidine; Base Sequence; Carcinoma, Ehrlich Tumor; Crystallins; DNA Methylation; DNA-Binding Proteins; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; HeLa Cells; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Leukemia; Molecular Chaperones; Molecular Sequence Data; Neoplasm Proteins; Point Mutation; Promoter Regions, Genetic; Protein Conformation; RNA, Messenger; Sequence Analysis, DNA; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1998 |
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Burkitt Lymphoma; Calcium-Calmodulin-Dependent Protein Kinases; CpG Islands; Death-Associated Protein Kinases; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Humans; Interferon-gamma; Leukemia; Lymphocytes; Lymphoma, T-Cell; Tumor Cells, Cultured | 1999 |
Sensitization by 5-aza-2'-deoxycytidine of leukaemia cells with MLL abnormalities to induction of differentiation by all-trans retinoic acid and 1alpha,25-dihydroxyvitamin D3.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Calcitriol; Cell Differentiation; Chromosome Breakage; Chromosomes, Human, Pair 11; Decitabine; DNA Methylation; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogenes; Transcription Factors; Tretinoin; Tumor Cells, Cultured | 2001 |
Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Cells; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; DNA Modification Methylases; Drug Evaluation; Drug Resistance; Enzyme Inhibitors; Flow Cytometry; Gene Transfer Techniques; Genetic Vectors; Green Fluorescent Proteins; Humans; Leukemia; Luminescent Proteins; Retroviridae; Transgenes | 2001 |
[Mechanism of cystostatic effect of 5-azacytidine and its usefulness in clinic].
Topics: Adult; Animals; Azacitidine; Child; Humans; Immunosuppressive Agents; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice | 1975 |
[New drugs for the therapy of acute leukemia].
Topics: Acute Disease; Antineoplastic Agents; Azacitidine; Cytarabine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Guanazole; Humans; Leukemia; Lomustine; Peptichemio; Podophyllotoxin; Razoxane; Zinostatin | 1975 |
Deoxycytidine kinase: properties of the enzyme from human leukemic granulocytes.
Topics: Azacitidine; Blood Proteins; Cell Separation; Cell-Free System; Cytarabine; Cytidine Deaminase; Deoxycytidine; Granulocytes; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Molecular Weight; Phosphates; Phosphotransferases; Tissue Extracts; Uridine Kinase | 1975 |
The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion.
Topics: Azacitidine; Chromatography, Thin Layer; Erythrocytes; Feces; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infusions, Parenteral; Injections, Intravenous; Leukemia; Leukocytes; Magnetic Resonance Spectroscopy; Neoplasm Metastasis; Nucleic Acids; Serum Albumin; Solvents; Sputum; Temperature; Time Factors; Urea | 1976 |
Biochemical pharmacology of cytidine analog metabolism in human leukemic cells.
Topics: Acute Disease; Adolescent; Adult; Aged; Azacitidine; Cytarabine; Cytidine Deaminase; Humans; In Vitro Techniques; Leukemia; Middle Aged; Phosphotransferases; Uridine Kinase | 1975 |
The therapy of acute leukemia in the adult: a progress report.
Topics: Acute Disease; Adult; Antineoplastic Agents; Azacitidine; Blood Transfusion; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Granulocytes; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Patient Isolation; Platelet Transfusion; Pneumonia; Prednisone; Pyrimethamine; Remission, Spontaneous; Thioguanine; Vincristine; Zinostatin | 1976 |
5-azacytidine in acute leukemia.
Topics: Acute Disease; Adult; Azacitidine; Bone Marrow; Central Nervous System; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Remission, Spontaneous; Time Factors | 1978 |
Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Azacitidine; Cell Survival; Drug Synergism; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Leukemia; Leukemia, Experimental; Mice; Mice, Inbred Strains; Orotic Acid; Pyrazoles; Ribonucleosides; Ribose | 1978 |
Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype.
Topics: Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; DNA; Humans; Leukemia; Methylation; Phenotype; Tumor Cells, Cultured | 1990 |
The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia.
Topics: Acute Disease; Adult; Amsacrine; Antigens, CD; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Decitabine; Drug Resistance; Female; Humans; Leukemia; Male; Middle Aged; Recurrence | 1991 |
Sample preparation for the determination of 5-aza-2'-deoxycytidine in plasma by high-performance liquid chromatography.
Topics: Adolescent; Adult; Antineoplastic Agents; Azacitidine; Chromatography, High Pressure Liquid; Decitabine; Humans; Kinetics; Leukemia; Middle Aged; Spectrophotometry, Ultraviolet | 1985 |
3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.
Topics: 3-Deazauridine; Acute Disease; Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; Drug Evaluation; Drug Synergism; Galactosamine; Humans; Kinetics; Leukemia; Neoplasms; Thymidine; Uridine | 1986 |
Determination of the antileukemia agents cytarabine and azacitidine and their respective degradation products by high-performance liquid chromatography.
Topics: Azacitidine; Biotransformation; Chromatography, High Pressure Liquid; Cytarabine; Drug Stability; Humans; Indicators and Reagents; Kinetics; Leukemia; Powders; Spectrophotometry, Ultraviolet | 1986 |
Amsacrine [4'-(9-acridinylamino)-methanesulfon-m-anisidide] (m-AMSA) and 5-azacytidine (AZA) for remission reinduction in patients with relapsed adult acute nonlymphocytic leukemia. An ECOG pilot study. Eastern Cooperative Oncology Group.
Topics: Acute Disease; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Drug Evaluation; Female; Heart; Humans; Leukemia; Male; Middle Aged; Pilot Projects | 1987 |
Combined etoposide and 5-azacitidine in children and adolescents with refractory or relapsed acute nonlymphocytic leukemia: a Pediatric Oncology Group Study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Drug Administration Schedule; Etoposide; Female; Humans; Leukemia; Male; Remission Induction; Time Factors | 1987 |
Effect of deoxycytidine on the metabolism and cytotoxicity of 5-aza-2'-deoxycytidine and arabinosyl 5-azacytosine in normal and leukemic human myeloid progenitor cells.
Topics: Acute Disease; Azacitidine; Bone Marrow; Decitabine; Deoxycytidine; Deoxycytosine Nucleotides; DNA, Neoplasm; Hematopoietic Stem Cells; Humans; Leukemia; Neoplastic Stem Cells | 1987 |
Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.
Topics: Azacitidine; DNA, Neoplasm; Drug Synergism; Gene Expression Regulation; HLA Antigens; Humans; Interferon-gamma; Kinetics; Leukemia; Methylation; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1987 |
Cellular metabolism of 5,6-dihydro-5-azacytidine and its incorporation into DNA and RNA of human lymphoid cells CEM/O and CEM/dCk(-).
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line; DNA, Neoplasm; Humans; Leukemia; Lymphocytes; Methylation; Mutation; RNA, Neoplasm; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |
Cellular metabolism of 1-beta-D-arabinofuranosyl-5-azacytosine and incorporation into DNA and RNA of human lymphoid CEM/0 and CEM/dCk(-) cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methylation; RNA, Neoplasm; Stereoisomerism; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |