azacitidine has been researched along with Invasiveness, Neoplasm in 136 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.74) | 18.7374 |
| 1990's | 3 (2.21) | 18.2507 |
| 2000's | 26 (19.12) | 29.6817 |
| 2010's | 103 (75.74) | 24.3611 |
| 2020's | 3 (2.21) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S; Ge, R; Huang, L; Jiang, H; Mao, J; Sheng, L | 1 |
| Cheng, T; Guo, W; Ruan, F; Wei, B; Xiang, M; Xu, X | 1 |
| Chen, Z; Li, X; Ma, X; Wei, L; Wu, X; Zou, L | 1 |
| An, X; Cai, W; Guo, C; Li, M; Miao, W; Wang, B; Wei, J; Zhang, C; Zhang, F | 1 |
| Li, JR; Li, SY; Sun, LL; Yang, SM; Yu, HB | 1 |
| Bai, Y; Chang, D; Li, M; Liu, C; Lv, D; Sun, G; Zhang, X | 1 |
| Bian, E; Guo, Z; Li, G; Ma, CC; Wan, J; Zhao, B | 1 |
| Abaza, YM; Alfonso, A; Borthakur, G; Chang, JE; Chong, TH; Chuah, C; Dong, XQ; Durkes, DE; Estrov, Z; Ferrajoli, A; Foudray, MC; Garcia-Manero, G; Goh, BC; Jabbour, EJ; Kadia, TM; Kantarjian, HM; Koh, LP; Konopleva, MY; Wierda, WG | 1 |
| Guo, D; Peng, H; Wu, D; Yang, X; Zhao, C; Zhao, W; Zhou, X | 1 |
| Cao, YM; Gu, J; Ji, QH; Liao, T; Qu, N; Shi, RL; Sun, GH; Wang, Y; Wang, YJ; Wei, WJ; Wen, D; Yu, J; Zhang, L; Zhang, YS; Zhao, YX; Zhu, YX | 1 |
| Attwood, K; Chatta, G; Granger, V; Gueron, G; Guru, K; Hu, Q; Johnson, C; Krishnan, N; McNally, L; Morrison, C; Pili, R; Rak, M; Ramakrishnan, S; Smit, E; Wang, D; Wang, J; Woloszynska-Read, A | 1 |
| Chen, LH; Dong, JY; Hu, KF; Liu, J; Ma, LZ; Peng, H; Sun, Y; Yang, QY; Yang, XL | 1 |
| Chen, Y; Rong, X; Su, L; Zhang, X | 1 |
| Ding, C; Dong, Z; Guo, W; Guo, Y; Liang, J; Liu, S; Shan, B; Shen, S | 1 |
| Bharti, R; Das, AK; Dey, G; Mandal, M | 1 |
| Bushell, MD; Godfrey, JD; Morton, JP; Sansom, OJ; Wilczynska, A | 1 |
| Chen, X; Ji, HL; Luo, YK; Mao, TM; Shi, PF; Zhou, J; Zhou, KY | 1 |
| Fan, Y; Guo, F; Song, D; Sun, Q; Wang, J; Wang, L; Zhang, D; Zhang, Q; Zhang, W | 1 |
| He, TC; Liu, JX; Shao, ZW; Sheng, W; Shi, DY; Wang, BC; Wu, Q; Yang, SH; Zhang, ZC | 1 |
| Chen, JK; Lai, Y; Liang, WL; Lin, Y; Wang, HY; Yan, FD; Yu, Z; Yuan, YH; Zhong, W | 1 |
| Chen, D; Chen, LH; Dong, JY; Hu, KF; Liu, J; Peng, H; Wu, WB; Yang, XL; Zhao, YN | 1 |
| Agarwal, C; Agarwal, R; Chan, D; Mateen, S; Raina, K | 1 |
| Arneth, BM; Fuessel, S; Hagelgans, A; Menschikowski, M; Nacke, B; Siegert, G; Wirth, MP | 1 |
| Bendinelli, P; Desiderio, MA; Locatelli, A; Maroni, P; Matteucci, E | 1 |
| Brewer, MA; Meng, F; Sun, G; Yu, Y; Zhong, M | 1 |
| Hu, J; Jiang, B; Liang, Y; Wang, B; Wang, X; Wang, Z; Xu, B; Zhang, Y; Zhou, J | 1 |
| Anastasiadis, PZ; Andorfer, CA; Borges, S; Döppler, H; Geiger, XJ; Perez, EA; Storz, P; Sun, Z; Thompson, E | 1 |
| Antonicelli, F; Brassart-Pasco, S; Diederich, M; Dufer, J; Kosciarz, A; Poplineau, M; Schnekenburger, M; Trussardi-Régnier, A | 1 |
| Azevedo-Pouly, AC; Elgamal, OA; Gusev, Y; Jiang, J; Park, JK; Roopra, A; Schmittgen, TD | 1 |
| Akhtar, J; Chen, HX; Liu, H; Wang, S; Wang, Z | 1 |
| Cho, YG; Han, J; Han, JY; Hong, SH; Hwang, JA; Kim, DH; Kim, Y; Kim, YH; Lee, J; Lee, YS; Shim, YM | 1 |
| Cheng, Y; Dang, C; Diao, D; Guo, Q; Liu, D; Song, Y; Wang, W; Wu, X; Xia, P; Zhang, H | 1 |
| Borges, S; Döppler, HR; Storz, P | 1 |
| Chen, HX; Liu, H; Wang, S; Wang, Z | 1 |
| Shang, ZJ; Shen, H; Song, K; Xia, XY; Zhang, HZ; Zhu, F | 1 |
| Bai, SY; Jiao, F; Ma, Y; Wang, J; Wang, X; Yan, ZH; Yu, Y; Yue, Z | 1 |
| Geng, P; Liu, K; Yao, J; Zhang, J; Zhou, B; Zhu, W; Zhu, Y | 1 |
| Hou, SY; Liu, WH; Sang, MX; Shan, BE; Zhang, C | 1 |
| Boureau, L; Cheishvili, D; Szyf, M | 1 |
| Arakelian, A; Bhattacharya, B; Cheishvili, D; Chik, F; Hallett, M; Li, CC; Rabbani, SA; Suderman, M; Szyf, M | 1 |
| Braun-Prado, K; Camargo, AA; Chequin, A; Costa, ET; Costa, FF; Klassen, G; Klassen, LM; Manica, GC; Pedrosa, Fde O; Pereira, IT; Ramos, EA; Souza, EM | 1 |
| Gopinath, KS; Kumar, A; Shivananda, S; Tiwari, A | 1 |
| Choi, YW; Devanand, P; Kim, SI; Kim, SJ; Kim, WJ; Lim, IK; Ryu, MS; Sheen, SS; Yim, H | 1 |
| Ahn, JH; Ju, W; Sung, HY | 1 |
| Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J | 1 |
| Fan, C; Jiang, G; Lin, X; Liu, Y; Miao, Y; Wang, E; Wang, L; Xu, X; Yu, J; Zhang, X; Zhang, Y | 1 |
| Chu, TY; Ding, DC; Huang, RL; Lin, CJ; Liu, CJ; Liu, DW; Wang, KH; Weng, CF | 1 |
| Cao, Y; Chen, H; Jiang, M; Jie, Z; Le, Z; Li, D; Li, Z; Liu, Y; Tan, S; Xiong, J; Zhang, G | 1 |
| Fan, JJ; Gao, Y; Li, HY; Li, Y; Ma, DM; Mai, L; Song, FZ; Wu, JY; Zeng, F; Zhang, J | 1 |
| Chen, ZW; Huang, SY; Li, WG; Wu, HW; Zhang, DS; Zhang, SZ; Zhou, XQ | 1 |
| Chiyomaru, T; Enokida, H; Goto, Y; Higashimoto, I; Inoue, H; Mataki, H; Matsushita, R; Mizuno, K; Nakagawa, M; Nishikawa, R; Samukawa, T; Seki, N | 1 |
| Jiang, X | 1 |
| Dong, Z; Guo, W; Guo, X; Guo, Y; Kuang, G; Shen, S; Wang, C | 1 |
| Dong, R; He, X; Li, J; Qiu, H; Wang, Y; Yu, J | 1 |
| Jiang, P; Lee, S; Lee, W; Xiang, Y; Yu, G; Zhang, C; Zhang, Y; Zhu, Z | 1 |
| Kwan, R; Looi, KS; Omary, MB | 1 |
| Hosokawa, M; Iwakawa, S; Tanaka, S; Ueda, K | 1 |
| Evers, BM; Kim, JT; Lee, EY; Li, J; Song, J; Townsend, CM; Weiss, HL | 1 |
| Bu, JY; Cui, RJ; Du, YD; Huang, N; Li, D; Lin, P; Sun, H; Tang, JB; Xu, CY; Yang, ZK; Yu, XG | 1 |
| Chen, CT; Lee, MJ; Li, PT; Tsai, YJ | 1 |
| Kang, HW; Kim, JS; Kim, WJ; Kim, WT; Kim, YJ; Kim, YW; Lee, SC; Ryu, KH; Yoon, HY; Yun, SJ | 1 |
| He, C; Jiang, H; Xu, R; Zhao, X; Zhong, Z | 1 |
| Ding, L; Jin, LY; Kong, B; Lv, ZD; Wang, Y; Yang, ZC | 1 |
| Chen, J; Qiu, X; Wang, Z; You, Y; Zhang, Z | 1 |
| Li, SS; Liu, JJ; Liu, ZH; Yang, XM | 1 |
| Anaka, M; Behren, A; Cebon, J; Chueh, AC; Davalos-Salas, M; Jayachandran, A; Lo, PH; Molania, R; Prithviraj, P; Walkiewicz, M | 1 |
| Alves, CP; de Araújo, LF; de Molfetta, GA; Dinarte-Santos, AR; Lima e Bueno, Rde B; Lorenzi, JC; Muys, BR; Ramão, A; Silva, WA; Vidal, DO; Zanette, DL | 1 |
| Chen, ML; Gao, BQ; Hao, S; Kang, XC; Yang, F; Yang, QH; Zheng, WW | 1 |
| Kong, X; Liu, A; Liu, J; Liu, Y; Su, Y; Sun, P; Wang, X; You, D; Yuan, L; Zhang, D; Zhang, X | 1 |
| Dang, Q; Dong, B; Guo, Y; Jin, X; Li, Y; Lin, D; Liu, Y; Lu, Y; Quan, C; Ruan, Y; Song, P; Xie, Y; Yang, M; Zhao, S | 1 |
| Kim, SJ; Yu, SM | 1 |
| Carosella, ED; Daunay, A; de Almeida, BS; Donadi, EA; Moreau, P; Poras, I; Simoes, RT; Tost, J; Yaghi, L | 1 |
| Bensaddek, D; Endo, A; Lamond, AI; Ly, T; Nicolas, A; Pippa, R | 1 |
| Han, ZB; Hao, J; Huang, C; Jia, Z; Jiang, W; Li, Y; Ren, H; Sun, Y; Wang, H; Wang, X; Xie, K; Yang, S; Zhao, T; Zheng, C | 1 |
| Duan, Y; Han, X; Jia, Y; Liu, L; Lv, W; Ma, M; Wang, J; Wang, X; Wang, Y | 1 |
| Cui, J; Huang, Q; Lai, M; Lin, J; Ma, Y; Ruan, W | 1 |
| Kim, HS; Lee, ES; Lee, JO; Lee, YM; Park, SH; Uhm, KO | 1 |
| Bui, C; Coughtrie, MW; Fournel-Gigleux, S; Ouzzine, M; Prydz, K; Sharp, S; Talhaoui, I | 1 |
| Abraham, JM; Agarwal, R; Cheng, Y; David, S; Hamilton, JP; Jin, Z; Meltzer, SJ; Montgomery, E; Mori, Y; Morin, PJ; Olaru, AV; Selaru, FM; Yang, J | 1 |
| Li, N; Qu, PP; Shi, Z | 1 |
| Bischof, J; Bonaldo, MF; Costa, FF; Hamm, CA; Hendrix, MJ; Seftor, EA; Soares, MB; Sredni, ST; Vanin, EF; Wang, D; Xie, H | 1 |
| Hueng, DY; Jan, HJ; Lai, JH; Lee, CC; Lee, HM; Ma, HI; Shih, YL; Wei, HW | 1 |
| Chiyomaru, T; Enokida, H; Kawahara, K; Kawakami, K; Matsuda, R; Matsumoto, M; Nakagawa, M; Nishiyama, K; Seki, N; Toki, K | 1 |
| Brieger, J; Fruth, K; Hedrich, J; Mann, SA; Mann, WJ; Pogozelski, B; Pongsapich, W | 1 |
| Chen, JY; Hong, CQ; Ran, YG; Wu, X; You, YJ | 1 |
| Dong, ZM; Fang, XH; Ge, MH; Hu, FJ; Li, P; Ling, ZQ; Mao, WM; Zhao, X | 1 |
| Auersperg, N; Cheng, JC; Leung, PC | 1 |
| Chen, HM; Du, W; Fang, JY; Hong, J; Tang, JT; Wang, JL; Wang, YC; Xiong, H; Zhao, SL | 1 |
| Bhattacharyya, B; Hallett, M; Han, ZG; Huang, J; Stefanska, B; Suderman, M; Szyf, M | 1 |
| Byrne, DJ; Dobrovic, A; Fox, SB; Huang, KT; Mikeska, T; Takano, EA | 1 |
| Bouizar, Z; Busato, F; Dupont, JM; Hamzaoui, H; Mourah, S; Neyret, A; Tost, J | 1 |
| Ari, F; Colling, C; Dere, E; Honert, K; Kiechle, M; Krüger, A; Napieralski, R; Schmitt, M; Ulukaya, E | 1 |
| Nalls, D; Rodova, M; Shankar, S; Srivastava, RK; Tang, SN | 1 |
| Cui, Y; Gu, J; Guo, S; He, Y; Luo, X; Ma, K; Wang, W | 1 |
| Jung, G; Lim, SO; Quan, X | 1 |
| Anant, S; Benbrook, DM; Lightfoot, S; Mills, WK; Natarajan, G; Queimado, L; Ramachandran, I; Ramalingam, S; Reis, A; Thavathiru, E; Zuna, R | 1 |
| Akahira, J; Hiroki, E; Ito, K; Miki, Y; Nagase, S; Sasano, H; Sugawara, J; Suzuki, F; Suzuki, T; Yaegashi, N | 1 |
| Alonso, MM; Aramburu, A; Bandrés, E; Cortes-Santiago, N; Diez-Valle, R; Fueyo, J; García-Foncillas, J; Gomez-Manzano, C; Idoate, MA; Jauregi, P; Lang, FF; Liu, D; Lopez de Munain, A; Manterola, L; Odero, MD; Rubio, A; Sampron, N; Tejada-Solís, S; Urquiza, L; Vicente, C | 1 |
| Daaka, Y; Gersey, Z; Kim, WJ | 1 |
| Liu, YP; Nie, XC; Takano, Y; Xia, P; Xing, YN; Xu, XY; Yang, X; Yu, M; Zheng, HC | 1 |
| Li, CL; Li, JF; Liu, BY; Nie, H; Qu, QL; Su, LP; Wang, M; Yan, M; Yu, YY; Zhu, ZG | 1 |
| Chen, R; Hu, Q; Ji, L; Liao, QP; Wang, YL; Xie, Y; Yu, L; Zhang, Y | 1 |
| Deng, D; Gu, L; Xiang, S; Yin, Y; Zhang, B; Zhong, Q | 1 |
| Chen, HQ; Liang, Y; Ma, YL; Moyer, MP; Qin, HL; Shen, TY; Shi, CZ; Wang, F; Yang, YZ; Zhang, HZ; Zhang, P | 1 |
| Di, W; Gu, L; Zhang, S; Zhu, J | 1 |
| Bernal, T; Gutiérrez-Fernández, A; Moncada-Pazos, A; Soria-Valles, C | 1 |
| Baraty, C; Bianco, C; Castro, NP; Gonzales, M; Held, N; Karasawa, H; Rangel, MC; Rollman, K; Salomon, DS; Strizzi, L | 1 |
| Chang, KW; Chiang, WF; Chu, TH; Gong, NR; Lin, SC; Liu, CJ; Wu, CH; Yang, CC | 1 |
| Hu, Q; Liao, QP; Yu, L | 1 |
| Bezrookove, V; Dar, AA; de Semir, D; Kashani-Sabet, M; Majid, S; Miller, JR; Nosrati, M; Rittsteuer, C; Sagebiel, R; Tong, S | 1 |
| Deng, G; Han, SW; Ho, JJ; Kim, YS; Kuan, SF; Pan, PL | 1 |
| Goggins, M; Maehara, N; Sato, N; Su, GH | 1 |
| Longo, M; Nelson, PS; Schuster, JM | 1 |
| Doihara, H; Dote, H; Shimizu, N; Teramoto, A; Toyooka, S; Tsukuda, K; Yano, M | 1 |
| Dai, JL; Liu, H; Sahin, A; Yuan, Y | 1 |
| Grimm, MO; Jackson, P; Loberg, R; Marreiros, A; Nixdorf, S; Pienta, KJ; Russell, PJ | 1 |
| Ito, R; Nakayama, H; Oda, N; Yasui, W; Yoshida, K | 1 |
| Furukawa, T; Horii, A; Kanai, N; Sunamura, M; Xu, S | 1 |
| Albergaria, A; Jerónimo, C; Milanezi, F; Oliveira, JT; Paredes, J; Schmitt, FC | 1 |
| Baba, H; Egami, H; Ikeda, K; Ishikawa, N; Iyama, K; Nakao, M; Ninomiya, Y; Sado, Y | 1 |
| Bae, HI; Kim, DS; Kim, MJ; Kim, SG; Lee, JY; Lee, YM; Park, JY | 1 |
| Carvalho, AL; Cerveira, N; Costa, VL; Henrique, R; Hoque, MO; Jerónimo, C; Oliveira, J; Ribeiro, FR; Sidransky, D; Teixeira, MR | 1 |
| Chang, HC; Cho, CY; Hung, WC | 1 |
| Chang, CK; Chang, HC; Cho, CY; Hung, WC; Wang, JH | 1 |
| Chan, CY; Cheung, OF; Ching, YP; Lee, JM; Ng, IO; Ng, YL; Tung, EK; Wong, CC; Wong, CM | 1 |
| Imreh, S; Klein, G; Popescu, NC; Zhou, X | 1 |
| Li, K; Li, Z; Teng, L; Wei, L; Wu, K; Yu, P; Zhang, C; Zhu, J | 1 |
| Fukuyoshi, Y; Inoue, H; Ishii, H; Kita, Y; Mimori, K; Mori, M; Motoyama, K; Ohta, M; Yamashita, K | 1 |
| Cho, JS; Jang, HR; Jeong, HY; Kim, JH; Kim, M; Kim, SY; Kim, YS; Lee, KT; Noh, SM; Song, KS; Yoo, HS | 1 |
| Chen, XP; Gutmann, DH; Huang, ZY; Xiao, ZY; Xiong, M; Yan, Q; Zhang, ZF | 1 |
| Hirohashi, S; Kanai, Y; Ochiai, A; Shimoyama, Y; Sugimura, T; Yoshiura, K | 1 |
| Prasanna, P; Samid, D; Shack, S; Wilson, VL | 1 |
| Rabbani, SA; Xing, RH | 1 |
| Clark, S; Jackson, P; Kingsley, E; Millar, D; Ow, K; Russell, PJ; Yardley, G | 1 |
| Bae, SI; Kim, SH; Kim, WH; Lee, HS | 1 |
| Takenaga, K | 1 |
2 review(s) available for azacitidine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
DNA demethylation and invasive cancer: implications for therapeutics.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms | 2015 |
Modification of the metastatic potential of tumor cells by drugs.
Topics: Animals; Azacitidine; Butyrates; Butyric Acid; Carcinoma; Cell Division; Cell Line; Cells, Cultured; Dimethyl Sulfoxide; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplastic Cells, Circulating; Phenotype | 1986 |
2 trial(s) available for azacitidine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Azacitidine; Benzimidazoles; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hematologic Neoplasms; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; Neoplasm Invasiveness; Neoplasm Staging; Patient Safety; Risk Assessment; Sex Factors; Survival Analysis; Treatment Outcome | 2017 |
MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Blotting, Western; Cell Movement; Cell Proliferation; Chromatin Immunoprecipitation; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Primers; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Immunoenzyme Techniques; Luciferases; Lymphatic Metastasis; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2011 |
132 other study(ies) available for azacitidine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
miRNA-204-5p acts as tumor suppressor to influence the invasion and migration of astrocytoma by targeting ezrin and is downregulated by DNA methylation.
Topics: Astrocytoma; Azacitidine; Cell Line, Tumor; Cell Movement; CpG Islands; Cytoskeletal Proteins; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; MicroRNAs; Neoplasm Invasiveness | 2021 |
The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells.
Topics: Azacitidine; Bone Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; DNA Methylation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Neoplasm Invasiveness; Neoplastic Stem Cells; Osteosarcoma; Ouabain; Sodium-Potassium-Exchanging ATPase | 2019 |
Demethylation of miR-195 suppresses prostate cancer cell proliferation, migration and invasion.
Topics: Apoptosis; Azacitidine; Cell Movement; Cell Proliferation; CpG Islands; Demethylation; DNA Methylation; Down-Regulation; Epithelial-Mesenchymal Transition; Genes, Tumor Suppressor; Humans; Male; MicroRNAs; Neoplasm Invasiveness; PC-3 Cells; Promoter Regions, Genetic; Prostatic Neoplasms; Signal Transduction; Transfection | 2020 |
Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.
Topics: Azacitidine; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Disease Progression; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Humans; Models, Biological; Neoplasm Invasiveness; Promoter Regions, Genetic; Receptors, Interleukin-15; Recombinant Proteins; RNA, Messenger; Stomach Neoplasms; Survival Analysis; Up-Regulation | 2020 |
Repression of DOK7 mediated by DNMT3A promotes the proliferation and invasion of KYSE410 and TE-12 ESCC cells.
Topics: Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Muscle Proteins; Neoplasm Invasiveness; Promoter Regions, Genetic | 2017 |
Hypermethylation of miRNA-589 promoter leads to upregulation of HDAC5 which promotes malignancy in non-small cell lung cancer.
Topics: Aged; Animals; Azacitidine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Male; Mice; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2017 |
TGF-β-mediated repression of MST1 by DNMT1 promotes glioma malignancy.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Hepatocyte Growth Factor; Humans; Neoplasm Invasiveness; Proto-Oncogene Proteins; Transforming Growth Factor beta; Up-Regulation | 2017 |
OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Azacitidine; Biopsy; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Down-Regulation; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; RNA, Messenger | 2017 |
Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation.
Topics: Apoptosis; Azacitidine; Carcinoma, Papillary; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Male; Mutation; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Neoplasms; Transcription Factors | 2018 |
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer.
Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Azacitidine; beta-Galactosidase; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Keratin-5; Muscle, Smooth; Neoplasm Invasiveness; Receptor, Notch1; Signal Transduction; Treatment Outcome; Urinary Bladder Neoplasms | 2017 |
[The Study of Methylated Regulation MicroRNA in Pancreatic Carcinoma Cell and Its Effect on Cell Proliferation,Migration and Invasion].
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Pancreatic Neoplasms; Promoter Regions, Genetic | 2017 |
Methylation-mediated loss of SFRP2 enhances invasiveness of non-small cell lung cancer cells.
Topics: A549 Cells; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Movement; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Membrane Proteins; Neoplasm Invasiveness; Promoter Regions, Genetic; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1 | 2018 |
Aberrant methylation-mediated silencing of lncRNA CTC-276P9.1 is associated with malignant progression of esophageal squamous cell carcinoma.
Topics: Adult; Aged; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; CpG Islands; Disease Progression; DNA Methylation; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Silencing; Humans; Luciferases; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; RNA, Long Noncoding; Sp1 Transcription Factor; Survival Analysis; Up-Regulation | 2018 |
Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer.
Topics: Animals; Antigens, CD; Azacitidine; Breast Neoplasms; Cadherins; Cell Hypoxia; Cell Line, Tumor; Chick Embryo; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Models, Biological; Monoamine Oxidase; Neoplasm Invasiveness; Receptors, Interleukin-6; Vascular Endothelial Growth Factor A | 2018 |
MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genetic Loci; Humans; Mice; MicroRNAs; Mutation; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53 | 2018 |
[The relationship between hypermethylation of Syk gene promoter and medulloblastoma cell invasion and metastasis].
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Cerebellar Neoplasms; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Medulloblastoma; Neoplasm Invasiveness; Promoter Regions, Genetic; Syk Kinase | 2016 |
Hypermethylated CD36 gene affected the progression of lung cancer.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; CD36 Antigens; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Neoplasm Invasiveness; Xenograft Model Antitumor Assays | 2018 |
Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; Chondrosarcoma; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Eye Proteins; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Structure-Activity Relationship; Wnt Signaling Pathway | 2018 |
Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway.
Topics: Apoptosis; Azacitidine; Cell Movement; Cell Proliferation; Colonic Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Genomic Imprinting; Homeodomain Proteins; Humans; MAP Kinase Signaling System; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; rhoC GTP-Binding Protein; RNA, Messenger; Transcription Factors | 2019 |
[The Effect of Methylation Level of microRNA Promoter on the Expression of microRNAs and on the Proliferation, Migration and Invasion of Lung Cancer Cells].
Topics: A549 Cells; Azacitidine; Cell Movement; Cell Proliferation; DNA Methylation; Humans; Lung Neoplasms; MicroRNAs; Neoplasm Invasiveness; Promoter Regions, Genetic | 2019 |
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.
Topics: Antioxidants; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Decitabine; Drug Synergism; Enzyme Inhibitors; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Silybin; Silymarin; Transcription Factors; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
Deregulated expression of urokinase and its inhibitor type 1 in prostate cancer cells: role of epigenetic mechanisms.
Topics: Adenocarcinoma; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA, Neoplasm; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Prostate; Prostatic Neoplasms; Urokinase-Type Plasminogen Activator | 2013 |
Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.
Topics: Azacitidine; Bone Neoplasms; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Collagen; Dactinomycin; DNA Methylation; Drug Combinations; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Laminin; Mutation; Neoplasm Invasiveness; Peptides, Cyclic; Proteoglycans; Proto-Oncogene Protein c-ets-1; Receptor, Endothelin A; RNA Stability; RNA, Messenger; Transcription, Genetic | 2013 |
Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3.
Topics: Acetylation; Animals; Ascites; Azacitidine; Cadherins; Carcinogenesis; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C3H; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Ovarian Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured; Twist-Related Protein 1 | 2013 |
Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer.
Topics: 3' Untranslated Regions; Azacitidine; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cytidine Triphosphate; DNA Methylation; EGF Family of Proteins; Endothelial Growth Factors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Promoter Regions, Genetic; RNA, Messenger; Vascular Endothelial Growth Factor A | 2013 |
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Kinase C; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Array Analysis; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
The DNA hypomethylating agent, 5-aza-2'-deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Chromatin Assembly and Disassembly; Decitabine; DNA Methylation; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Promoter Regions, Genetic; Sp1 Transcription Factor; Sp3 Transcription Factor | 2015 |
Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.
Topics: 3' Untranslated Regions; Azacitidine; Base Pairing; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HMGB3 Protein; Humans; MicroRNAs; Neoplasm Invasiveness; Repressor Proteins; Tumor Suppressor Proteins | 2013 |
Alteration of runt-related transcription factor 3 gene expression and biologic behavior of esophageal carcinoma TE-1 cells after 5-azacytidine intervention.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Carcinoma, Squamous Cell; Cell Adhesion; Cell Movement; Cell Proliferation; Core Binding Factor Alpha 3 Subunit; DNA Methylation; DNA, Neoplasm; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis.
Topics: Adult; Azacitidine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Knockdown Techniques; Gene Silencing; Humans; Lung Neoplasms; Male; Neoplasm Invasiveness; Phenotype; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Sulfotransferases | 2013 |
Detection of aberrant hypermethylated spastic paraplegia-20 as a potential biomarker and prognostic factor in gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Case-Control Studies; Cell Cycle Proteins; DNA Methylation; Female; Follow-Up Studies; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Proteins; Stomach; Stomach Neoplasms; Survival Rate; Tumor Cells, Cultured | 2014 |
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Nude; Neoplasm Invasiveness; Phthalimides; Reverse Transcriptase Polymerase Chain Reaction; Suramin; Tryptophan; Xenograft Model Antitumor Assays | 2014 |
Effects of 5-azacytidine on RUNX3 gene expression and the biological behavior of esophageal carcinoma cells.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Core Binding Factor Alpha 3 Subunit; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Xenograft Model Antitumor Assays | 2014 |
Correlation of deregulated like-acetylglucosaminyl transferase and aberrant α-dystroglycan expression with human tongue cancer metastasis.
Topics: Azacitidine; Carcinoma, Squamous Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dystroglycans; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Glycosylation; Humans; Immunohistochemistry; Laminin; Lymphatic Metastasis; Male; Middle Aged; N-Acetylglucosaminyltransferases; Neoplasm Invasiveness; Neoplasm Staging; Plasmids; Promoter Regions, Genetic; Tongue Neoplasms; Transfection | 2014 |
DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
Topics: Azacitidine; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; MCF-7 Cells; Neoplasm Invasiveness; Promoter Regions, Genetic | 2014 |
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells.
Topics: ADAM Proteins; ADAMTS9 Protein; Adult; Aged; Azacitidine; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Female; Glioma; Humans; Male; Middle Aged; Neoplasm Invasiveness; RNA, Antisense; RNA, Long Noncoding; RNA, Small Interfering; Tumor Suppressor Proteins | 2014 |
Low-dose decitabine induces MAGE-A expression and inhibits invasion via suppression of NF-κB2 and MMP2 in Eca109 cells.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Decitabine; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Neoplasm Proteins; NF-kappa B p52 Subunit | 2014 |
Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.
Topics: Azacitidine; Breast Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Molecular Targeted Therapy; Neoplasm Invasiveness; Promoter Regions, Genetic | 2014 |
Fibronectin affects transient MMP2 gene expression through DNA demethylation changes in non-invasive breast cancer cell lines.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Fibronectins; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Time Factors; Transcriptional Activation | 2014 |
MicroRNA-125a reduces proliferation and invasion of oral squamous cell carcinoma cells by targeting estrogen-related receptor α: implications for cancer therapeutics.
Topics: Amino Acid Sequence; Animals; Apoptosis; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Decitabine; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Molecular Sequence Data; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Transplantation; Plasmids; Protein Binding; Sequence Homology, Amino Acid | 2014 |
Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1.
Topics: Azacitidine; Chromatin Assembly and Disassembly; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; Immediate-Early Proteins; Introns; Neoplasm Invasiveness; Promoter Regions, Genetic; Sp1 Transcription Factor; Tumor Suppressor Proteins; Up-Regulation; Urinary Bladder Neoplasms | 2014 |
DNA hypomethylation-mediated overexpression of carbonic anhydrase 9 induces an aggressive phenotype in ovarian cancer cells.
Topics: Animals; Azacitidine; Carbonic Anhydrases; Carcinoma, Ovarian Epithelial; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Phenotype; Promoter Regions, Genetic; RNA, Messenger | 2014 |
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin | 2014 |
Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis.
Topics: Aged; Azacitidine; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Membrane; Decitabine; DNA Methylation; Female; Gene Silencing; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Promoter Regions, Genetic; Wnt Signaling Pathway | 2014 |
Global methylation silencing of clustered proto-cadherin genes in cervical cancer: serving as diagnostic markers comparable to HPV.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Cadherins; Cell Adhesion; Cell Line, Tumor; CpG Islands; Disease Progression; DNA Methylation; Female; Gene Silencing; Genetic Loci; Humans; Middle Aged; Multigene Family; Neoplasm Invasiveness; Neoplasm Staging; Papillomaviridae; Papillomavirus Infections; Severity of Illness Index; Uterine Cervical Neoplasms | 2015 |
Methylation-associated silencing of miR-495 inhibit the migration and invasion of human gastric cancer cells by directly targeting PRL-3.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Gene Silencing; Genes, Tumor Suppressor; Humans; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Promoter Regions, Genetic; Protein Tyrosine Phosphatases; Sequence Analysis, DNA; Stomach Neoplasms | 2015 |
MiR-335 inhibits migration of breast cancer cells through targeting oncoprotein c-Met.
Topics: Azacitidine; Breast Neoplasms; Cell Movement; Cell Proliferation; Decitabine; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; MCF-7 Cells; MicroRNAs; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met | 2015 |
Effects of 5-aza-2'deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Adenoid Cystic; DNA Methylation; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Neoplasm Invasiveness; Salivary Gland Neoplasms | 2015 |
Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.
Topics: Aged; Aged, 80 and over; Azacitidine; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Lung Neoplasms; Male; Microfilament Proteins; MicroRNAs; Middle Aged; Multigene Family; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2015 |
[Effects of 5-aza-2-deoxycytidine on methylation status of RECK gene and cancer cell invasion in tongue cancer SCC-4 cells].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; GPI-Linked Proteins; Humans; Methylation; Neoplasm Invasiveness; RNA, Messenger; Tongue Neoplasms | 2014 |
RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Alternative Splicing; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cytidine Triphosphate; DNA Methylation; Esophageal Neoplasms; Esophagus; Female; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Hydroxamic Acids; Male; Middle Aged; Monomeric GTP-Binding Proteins; Neoplasm Invasiveness; Prognosis; Promoter Regions, Genetic; Protein Isoforms; Protein Synthesis Inhibitors; RNA, Messenger, Stored | 2015 |
Frequent Loss of NISCH Promotes Tumor Proliferation and Invasion in Ovarian Cancer via Inhibiting the FAK Signal Pathway.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Female; Focal Adhesion Kinase 1; Humans; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Loss of Heterozygosity; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; Promoter Regions, Genetic; Signal Transduction | 2015 |
Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Decitabine; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Microarray Analysis; Neoplasm Invasiveness; Peptides; Polymerase Chain Reaction; Receptors, Thrombin; Trefoil Factor-2 | 2015 |
Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion.
Topics: Animals; Azacitidine; Base Sequence; Cell Line, Tumor; DNA Methylation; Epithelial Cells; Epithelial-Mesenchymal Transition; Keratin-18; Keratin-8; Mice; Mutagenesis, Insertional; Neoplasm Invasiveness; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Analysis, DNA; Sequence Deletion; Vimentin | 2015 |
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Exosomes; Humans; MicroRNAs; Neoplasm Invasiveness; Organoplatinum Compounds; Oxaliplatin | 2015 |
Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
Topics: Azacitidine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunohistochemistry; Lentivirus; Neoplasm Invasiveness; Neuroendocrine Tumors; Promoter Regions, Genetic; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2015 |
DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD4‑1.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Endosomal Sorting Complexes Required for Transport; Humans; Nedd4 Ubiquitin Protein Ligases; Neoplasm Invasiveness; Stomach Neoplasms; Ubiquitin-Protein Ligases; Up-Regulation | 2015 |
Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment.
Topics: Acetylation; Aminolevulinic Acid; Azacitidine; Cell Line, Tumor; Cell Movement; Chromatin Immunoprecipitation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 9; MicroRNAs; Mitochondria; Neoplasm Invasiveness; Photochemotherapy; Promoter Regions, Genetic; Proteins | 2015 |
RSPH9 methylation pattern as a prognostic indicator in patients with non-muscle invasive bladder cancer.
Topics: Adult; Aged; Azacitidine; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cell Line, Tumor; Cytoskeletal Proteins; Disease-Free Survival; DNA Methylation; DNA, Neoplasm; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Prognosis; Proportional Hazards Models; Urinary Bladder Neoplasms | 2016 |
Demethylation of miR-10b plays a suppressive role in ccRCC cells.
Topics: Azacitidine; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; MicroRNAs; Neoplasm Invasiveness; Nuclear Proteins; Phenylbutyrates; Promoter Regions, Genetic; Time Factors; Transfection; Twist-Related Protein 1 | 2015 |
Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.
Topics: Adult; Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; Repressor Proteins; RNA Interference; RNA, Messenger; Transfection; Triple Negative Breast Neoplasms | 2015 |
Aberrant GRK6 promoter methylation is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.
Topics: Azacitidine; Carcinoma, Squamous Cell; Decitabine; DNA Methylation; Down-Regulation; G-Protein-Coupled Receptor Kinases; Gene Expression Regulation, Neoplastic; Humans; Hypopharyngeal Neoplasms; Neoplasm Invasiveness; Neoplasm Proteins; Prognosis; Promoter Regions, Genetic; RNA Interference; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering | 2016 |
Association of RUNX3 Methylation with Clinical Outcome and Cell Migration/Invasion in Laryngeal Squamous Cell Carcinoma.
Topics: Aged; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Core Binding Factor Alpha 3 Subunit; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck; Time Factors | 2016 |
Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Melanoma; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Transketolase; Up-Regulation | 2016 |
Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Cell Nucleus; Conserved Sequence; DNA Methylation; Evolution, Molecular; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Nucleic Acid Conformation; Placenta; Pregnancy; Protein Isoforms; Reproduction; RNA, Long Noncoding | 2016 |
Promoter methylation and expression of SOCS-1 affect clinical outcome and epithelial-mesenchymal transition in colorectal cancer.
Topics: Azacitidine; Cell Movement; Colorectal Neoplasms; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Suppressor of Cytokine Signaling 1 Protein; Survival Analysis; Treatment Outcome | 2016 |
Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.
Topics: Adult; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glucosyltransferases; Humans; MCF-7 Cells; Neoplasm Invasiveness; Promoter Regions, Genetic | 2016 |
DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Claudins; DNA Methylation; Epigenesis, Genetic; Female; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Methyl-CpG-Binding Protein 2; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Young Adult | 2016 |
5-Azacytidine regulates matrix metalloproteinase-9 expression, and the migration and invasion of human fibrosarcoma HT1080 cells via PI3-kinase and ERK1/2 pathways.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phosphorylation | 2016 |
Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2.
Topics: 5' Untranslated Regions; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Exons; Genes, MHC Class I; Glioma; HLA-G Antigens; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immune System; Neoplasm Invasiveness; Polymorphism, Genetic; Promoter Regions, Genetic; Response Elements; Transcriptional Activation | 2016 |
The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin Assembly and Disassembly; Epithelial Cells; Female; Humans; Mass Spectrometry; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Protein Subunits; Proteomics; Signal Transduction; Transcription Factors | 2017 |
ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.
Topics: Animals; Antigens, CD; Azacitidine; Cadherins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Decitabine; Humans; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Promoter Regions, Genetic; Transcription Factors; Tumor Suppressor Proteins; Up-Regulation | 2017 |
Methylation decreases the Bin1 tumor suppressor in ESCC and restoration by decitabine inhibits the epithelial mesenchymal transition.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Cycle; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nuclear Proteins; Prognosis; Promoter Regions, Genetic; Signal Transduction; Survival Rate; Tumor Cells, Cultured; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2017 |
Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro.
Topics: Azacitidine; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Decitabine; DNA; DNA Methylation; G1 Phase; Humans; Insulin-Like Growth Factor Binding Proteins; Neoplasm Invasiveness; RNA, Messenger; Transcription, Genetic | 2008 |
Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cell Line, Tumor; Cholangiocarcinoma; CpG Islands; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Integrin alpha4; Integrin beta1; Lymphatic Metastasis; Male; Methyltransferases; Middle Aged; Molecular Sequence Data; Neoplasm Invasiveness; Paxillin; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sequence Analysis, DNA; Transfection | 2010 |
Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.
Topics: Azacitidine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chondrosarcoma; CpG Islands; Decitabine; DNA Methylation; Enzyme Repression; HeLa Cells; Heparan Sulfate Proteoglycans; Heparitin Sulfate; HL-60 Cells; Humans; Neoplasm Invasiveness; Sulfotransferases; Up-Regulation | 2010 |
Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Claudins; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Neoplasm Invasiveness; Nerve Tissue Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stomach Neoplasms | 2009 |
[E-cadherin promoter methylation and demethylation in epithelial ovarian carcinoma cells].
Topics: Azacitidine; Cadherins; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic | 2009 |
Global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2'-deoxycytidine results in increased tumorigenicity.
Topics: Animals; Azacitidine; Cell Line, Tumor; Chondrosarcoma; Cytokines; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Long Interspersed Nucleotide Elements; Mice; Microsatellite Repeats; Midkine; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Rats; Sequence Analysis, DNA; SOXB1 Transcription Factors; Xenograft Model Antitumor Assays | 2009 |
Osteopontin regulates human glioma cell invasiveness and tumor growth in mice.
Topics: Animals; Antineoplastic Agents; Azacitidine; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Decitabine; Electrophoresis, Polyacrylamide Gel; Glioma; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Invasiveness; Osteopontin; Reverse Transcriptase Polymerase Chain Reaction; Vimentin; Xenograft Model Antitumor Assays | 2010 |
CpG hypermethylation of human four-and-a-half LIM domains 1 contributes to migration and invasion activity of human bladder cancer.
Topics: Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; DNA Methylation; Enzyme Inhibitors; Female; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Male; Middle Aged; Muscle Proteins; Neoplasm Invasiveness; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2010 |
Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Head and Neck Neoplasms; Humans; Kruppel-Like Transcription Factors; Male; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic | 2010 |
[Study on promoter methylation status of E-cadherin gene in nasopharyngeal carcinoma cell lines].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic | 2010 |
Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Azacitidine; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Shape; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Esophageal Neoplasms; Female; Humans; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Transcription, Genetic | 2011 |
Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells.
Topics: Azacitidine; Cadherins; Carcinoma; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Neoplasm Invasiveness; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Tumor Suppressor Protein p53 | 2011 |
Definition of the landscape of promoter DNA hypomethylation in liver cancer.
Topics: Aged; Azacitidine; Breast Neoplasms; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Ovarian Neoplasms; Promoter Regions, Genetic | 2011 |
Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HCT116 Cells; HL-60 Cells; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; Mutation; Neoplasm Invasiveness; Polymorphism, Genetic; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors | 2011 |
Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines.
Topics: 5' Flanking Region; Azacitidine; Breast Neoplasms; Cells, Cultured; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Parathyroid Hormone-Related Protein; Promoter Regions, Genetic | 2011 |
Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Urokinase-Type Plasminogen Activator | 2011 |
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.
Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatin; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Pancreatic Neoplasms; Spheroids, Cellular; Tumor Stem Cell Assay; Up-Regulation; Vorinostat | 2011 |
Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; DNA Methylation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Neoplasm Invasiveness; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-3 | 2011 |
Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter.
Topics: Acetylcysteine; Azacitidine; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Invasiveness; Octamer Transcription Factor-1; Promoter Regions, Genetic; Reactive Oxygen Species | 2011 |
Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Azacitidine; beta Catenin; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cervix Uteri; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Mice; Mice, Nude; Neoplasm Invasiveness; Neovascularization, Pathologic; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Uterine Cervical Neoplasms; Wnt Proteins | 2012 |
MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma.
Topics: Adenocarcinoma; Apoptosis; Azacitidine; Cell Cycle; Cell Division; Cell Line, Tumor; Decitabine; DNA Methylation; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Immunohistochemistry; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proto-Oncogene Mas; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.
Topics: Azacitidine; Blotting, Western; Cell Movement; Cell Proliferation; CpG Islands; DNA Methylation; DNA, Neoplasm; Epigenomics; Gene Amplification; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Humans; Neoplasm Invasiveness; Neoplastic Stem Cells; Phenotype; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; SOXB1 Transcription Factors; Tumor Cells, Cultured | 2011 |
Rap1GAP regulates renal cell carcinoma invasion.
Topics: Azacitidine; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Integrins; Kidney Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Small Interfering; Transfection | 2012 |
The roles of REIC gene and its encoding product in gastric carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Azacitidine; beta Catenin; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokines; Cyclin D2; Cyclin E; Decitabine; Gastric Mucosa; Humans; Intercellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Pseudopodia; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms; TOR Serine-Threonine Kinases; Wiskott-Aldrich Syndrome Protein Family | 2012 |
microRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis.
Topics: 3' Untranslated Regions; Azacitidine; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HEK293 Cells; Humans; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Smad2 Protein; Stomach Neoplasms | 2012 |
5-aza-2'-deoxycytidine improves the sensitivity of endometrial cancer cells to progesterone therapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Apoptosis; Azacitidine; Carcinoma; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; Drug Therapy, Combination; Endometrial Neoplasms; Female; Humans; Medroxyprogesterone Acetate; Neoplasm Invasiveness; Receptors, Progesterone | 2012 |
The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Cell Movement; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Histones; Humans; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Binding; Protein Engineering; Transcription Factors; Transcription, Genetic; Transfection; Up-Regulation; Zinc Fingers | 2012 |
SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer.
Topics: Azacitidine; Base Sequence; Cell Proliferation; Chi-Square Distribution; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Knockdown Techniques; Gene Silencing; HCT116 Cells; HT29 Cells; Humans; Kaplan-Meier Estimate; Male; MicroRNAs; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transfection | 2013 |
Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma.
Topics: Animals; Azacitidine; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Mice; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Wnt Signaling Pathway | 2012 |
Effects of azacitidine on matrix metalloproteinase-9 in acute myeloid leukemia and myelodysplasia.
Topics: Aged; Aged, 80 and over; Anemia, Refractory, with Excess of Blasts; Antimetabolites; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Catalysis; Cell Line, Tumor; Disease Progression; DNA Methylation; Drug Resistance, Neoplasm; Enzyme Induction; Female; Humans; Leukemia, Monocytic, Acute; Leukemia, Myelomonocytic, Acute; Male; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasms, Second Primary; Promoter Regions, Genetic; Risk | 2013 |
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Embryonal; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Luciferases; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Receptor Subfamily 6, Group A, Member 1; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Time Factors; Tissue Array Analysis; Transcription, Genetic; Transfection; Tretinoin; Valproic Acid | 2013 |
miR-370 modulates insulin receptor substrate-1 expression and inhibits the tumor phenotypes of oral carcinoma.
Topics: Azacitidine; Carcinogenesis; Carcinoma, Squamous Cell; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cells, Cultured; Decitabine; DNA Modification Methylases; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Insulin Receptor Substrate Proteins; Keratinocytes; MicroRNAs; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Oncogene Protein v-akt; RNA, Small Interfering; TOR Serine-Threonine Kinases | 2013 |
[Methylation of matrix metalloproteinases-2 promoter in endometrial cancer invasion].
Topics: Azacitidine; Decitabine; DNA Methylation; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 2012 |
The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatin Immunoprecipitation; DNA Methylation; Epithelial-Mesenchymal Transition; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Luciferases; Melanoma; MicroRNAs; Neoplasm Invasiveness; Neoplastic Stem Cells; Point Mutation; Proto-Oncogene Proteins c-mdm2; Real-Time Polymerase Chain Reaction; Signal Transduction; Skin Neoplasms; Transplantation, Heterologous; Tumor Suppressor Protein p53; Up-Regulation | 2013 |
Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Azacitidine; Base Sequence; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucins; Neoplasm Invasiveness; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm | 2003 |
Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinases; Methylation; Neoplasm Invasiveness; Pancreatic Neoplasms; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Membrane Glycoproteins; Methyltransferases; Neoplasm Invasiveness; Neoplasms; Oligonucleotide Array Sequence Analysis; Serine Proteinase Inhibitors; Trypsin Inhibitor, Kunitz Soybean; Tumor Cells, Cultured | 2003 |
Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Primers; DNA, Neoplasm; Female; Gene Frequency; Gene Silencing; GTPase-Activating Proteins; Humans; Neoplasm Invasiveness; Polymerase Chain Reaction; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2004 |
Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Breast Neoplasms; Carcinoma, Ductal; Carcinoma, Intraductal, Noninfiltrating; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Precursors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Phenotype; Protein-Tyrosine Kinases; Stilbenes; Syk Kinase | 2005 |
Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines.
Topics: Azacitidine; Clone Cells; Decitabine; DNA Methylation; Down-Regulation; Genes, Tumor Suppressor; Humans; Microfilament Proteins; Neoplasm Invasiveness; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder; Urinary Bladder Neoplasms | 2004 |
Loss of maspin expression is associated with development and progression of gastric carcinoma with p53 abnormality.
Topics: Adenoma; Azacitidine; Decitabine; Disease Progression; DNA Methylation; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Immunoenzyme Techniques; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serpins; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2004 |
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Topics: Acetylation; Adenocarcinoma; Azacitidine; Base Sequence; Carcinoma, Pancreatic Ductal; Cell Differentiation; CpG Islands; DNA Methylation; Dual Specificity Phosphatase 6; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Tyrosine Phosphatases; Tumor Cells, Cultured | 2005 |
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Azacitidine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cadherins; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Ki-67 Antigen; Middle Aged; Neoplasm Invasiveness; Predictive Value of Tests; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53 | 2005 |
Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region.
Topics: Aged; Aged, 80 and over; Azacitidine; Basement Membrane; Cell Line, Tumor; Collagen; Collagen Type IV; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Down-Regulation; Drug Combinations; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genes, Reporter; Humans; Laminin; Male; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Proteoglycans; RNA, Messenger | 2006 |
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Topics: Adenocarcinoma; Adenoma; Azacitidine; CpG Islands; DNA Methylation; DNA, Neoplasm; Gallbladder Neoplasms; Humans; Immunoenzyme Techniques; Microdissection; Neoplasm Invasiveness; Neoplasm Staging; Polymerase Chain Reaction; Promoter Regions, Genetic; Tissue Array Analysis; Tumor Cells, Cultured; Ubiquitin Thiolesterase | 2006 |
Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer.
Topics: Adenocarcinoma; Adult; Aged; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D2; Cyclins; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2006 |
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Topics: Aged; Amino Acid Motifs; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Membrane Glycoproteins; Mutation; Neoplasm Invasiveness; Promoter Regions, Genetic; ras Proteins | 2007 |
Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells.
Topics: Azacitidine; Base Sequence; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; GPI-Linked Proteins; Humans; In Vitro Techniques; Membrane Glycoproteins; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm | 2007 |
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic; Serine Proteinase Inhibitors | 2007 |
The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma.
Topics: Amino Acid Sequence; Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Interferon-alpha; Liver Neoplasms; Male; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Sequence Homology, Amino Acid | 2007 |
p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma.
Topics: Azacitidine; Carcinoma, Squamous Cell; Decitabine; DNA Methylation; DNA, Neoplasm; E1A-Associated p300 Protein; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm | 2007 |
Clinical significance of the reduced expression of G protein gamma 7 (GNG7) in oesophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma; Cell Line, Tumor; Chromosomes, Human, Pair 19; DNA Methylation; Down-Regulation; Esophageal Neoplasms; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; GTP-Binding Protein gamma Subunits; Humans; Loss of Heterozygosity; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Prognosis; RNA, Messenger | 2008 |
Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; DNA Restriction Enzymes; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Humans; Hydroxamic Acids; Male; Membrane Proteins; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms | 2008 |
Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma.
Topics: Adult; Aged; Azacitidine; Cadherins; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2008 |
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
Topics: Azacitidine; Base Sequence; Cadherins; Carcinoma; DNA Primers; DNA, Neoplasm; Gene Expression; Genes, Regulator; Genes, Tumor Suppressor; Humans; Methylation; Molecular Sequence Data; Neoplasm Invasiveness; Oligodeoxyribonucleotides; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1995 |
Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine-induced carcinogenesis.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Azacitidine; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Chemoprevention; Clone Cells; Collagen; Decitabine; DNA Methylation; Drug Combinations; Female; Genes, ras; Laminin; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasms, Experimental; Phenylacetates; Proteoglycans | 1995 |
Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation.
Topics: Azacitidine; Breast Neoplasms; Cell Line; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Transcription, Genetic; Urokinase-Type Plasminogen Activator | 1999 |
Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines.
Topics: Antigens, CD; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Carcinoma, Transitional Cell; CpG Islands; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Kangai-1 Protein; Membrane Glycoproteins; Methylation; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
Inactivation of O6-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Primers; Down-Regulation; Enzyme Inhibitors; Humans; Microsatellite Repeats; Mutation; Neoplasm Invasiveness; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Stomach; Stomach Neoplasms; Sulfites; Survival Rate; Transcription, Genetic; Tumor Cells, Cultured | 2002 |