azacitidine and Hepatocellular Carcinoma

azacitidine has been researched along with Hepatocellular Carcinoma in 117 studies

Research

Studies (117)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (13.68)	18.7374
1990's	1 (0.85)	18.2507
2000's	42 (35.90)	29.6817
2010's	54 (46.15)	24.3611
2020's	4 (3.42)	2.80

Authors

Authors	Studies
Huang, H; Huang, Y; Yang, X; Yu, Z; Zhao, L; Zheng, M	1
Chunmeng, M; Hasnat, M; Le, L; Luyong, Z; Qinwei, Y; Qipeng, W; Zhenzhou, J	1
Anfuso, B; Cabral, LKD; Dituri, F; Giannelli, G; Negro, R; Sukowati, C; Tiribelli, C	1
Busschaert, P; Cappuyns, S; Dekervel, J; Galle, E; Lambrechts, D; Roskams, T; Thienpont, B; Van Cutsem, E; Van Haele, M; van Pelt, J; Venken, T; Verslype, C	1
Guo, D; Peng, H; Wu, D; Yang, X; Zhao, C; Zhao, W; Zhou, X	1
Futaki, S; Hamamoto, H; Hayashi, M; Hirata, A; Kondo, Y; Maemura, K; Mizuno, Y; Otsuki, Y; Shibata, MA; Tanaka, Y; Taniguchi, K; Uchiyama, K	1
Gailhouste, L; Hatada, I; Liew, LC; Nakagama, H; Ochiya, T; Tanaka, Y; Yasukawa, K	1
Daniels, J; Dorff, TB; El-Khoueiry, A; Hinoue, T; Li, H; Liang, G; Liu, M; Lu, Q; O'Connell, C; Ohtani, H; Weisenberger, DJ; Zhang, L; Zhou, W	1
Dong, Q; Gao, X; Luo, Q; Qiao, P; Qin, L; Sheng, Y; Sun, H; Wang, C; Wang, X; Wei, J; Yan, S; Yang, J; Yu, X; Zhang, K; Zhang, R; Zhang, Y; Zhang, Z; Zhao, Y; Zheng, Y; Zhu, Y	1
Hlady, RA; Robertson, KD	1
Brock, MV; Guo, M; Herman, JG; Licchesi, JD; Liu, X; Pei, X; Yang, Y; Yue, W; Zhang, X	1
Dash, S; Feitelson, M; Han, C; Lim, K; Lu, D; Song, K; Wu, T; Zhang, J	1
Cai, X; Chen, K; Chen, Q; Huang, A; Li, S; Nie, D; Quan, H; Shan, X; Tang, N; Zhou, F; Zhou, Z	1
Dong, Y; Guo, M; Hu, L; Jing, K; Li, Y; Wu, K; Yan, W; Yang, Y; Yuan, J; Zhu, H	1
DU, Y; Lv, Z; Wen, J	1
Jiang, DF; Xing, TJ; Xu, HT; Yu, WQ	1
Li, CS; Li, T; Liu, QY; Liu, WJ; Liu, ZS; Ren, JG; Yu, GZ; Zhang, J	1
He, Y; Huang, C; Li, J; Long, XR	1
Arizumi, T; Chishina, H; Hagiwara, S; Inoue, T; Kitai, S; Kudo, M; Minami, Y; Nishida, N; Sakurai, T; Takita, M; Ueshima, K; Yada, N	1
Chen, G; Chen, H; Ding, B; Ye, X; Yin, L; Yin, M; Zhang, C; Zheng, Y; Zhou, X	1
Acun, T; Arango, D; Demir, K; Oztas, E; Yakicier, MC	1
Hashim, Z; Ilyas, A; Zarina, S	1
Chen, M; Duan, F; Han, W; Li, X; Lu, X; Luo, G; Mei, Q; Wang, M	1
Brock, MV; Guo, M; Herman, JG; Li, X; Liang, P; Tao, Q; Yu, J	1
El-Khoueiry, A; Kuang, Y; Ljungman, M; Neamati, N; Taverna, P	1
Gao, N; Jiang, G; Wu, J; Xi, Q; Yang, Y; Ye, W; Zhang, B; Zhang, X	1
Ko, CY; Lai, HY; Li, CF; Pan, YC; Tsai, HH; Wang, JM; Wu, WC; Yen, CJ; Yuh, CH	1
Chen, RP; Deng, W; Guo, YT; Li, R; Liu, LX; Pu, ZJ; Wang, GF; Wu, LF; Xiang, MQ; Zhou, XT	1
Agodi, A; Borghesan, M; Buschbeck, M; Cappello, F; Douet, J; Faulkes, C; Fusilli, C; Mazza, T; Mazzoccoli, G; Minogue, S; Oben, JA; Panebianco, C; Pata, I; Pazienza, V; Peterson, A; Rappa, F; Rezaee, F; Rizzo, G; Sedivy, JM; Vinciguerra, M; Warren, A	1
Baharvand, H; Dooley, S; Nussler, AK; Ruoss, M; Sajadian, SO; Samani, FS; Tripura, C	1
Allister, A; Ewald, F; Koch, A; Koch, M; Nashan, B; Saran, S; Tamura, T; Tran, DDH	1
Arici, B; De Petro, G; Grossi, I; Portolani, N; Salvi, A	1
Chan, DW; Chan, PC; Lee, JM; Ng, IO	1
Asaoka, Y; Fukai, K; Imazeki, F; Kanai, F; Kawabe, T; Muroyama, R; Ohta, M; Omata, M; Seto, M; Tada, M; Tanaka, Y; Tateishi, K; Yokosuka, O	1
Chan, AT; Cheng, YY; Cheung, KF; Ebert, MP; Jin, H; Li, H; Poon, FF; Röcken, C; Sung, JJ; Tao, Q; Wang, X; Yu, J	1
Chen, QX; Feng, XW; Wu, LM; Xie, HY; Zhang, F; Zheng, SS; Zhou, L	1
Deng, Y; Jin, J; Qin, W; Shu, H; Tang, N; Yang, S; Yao, G; You, H; Yu, B	1
Brooke, DG; Datta, J; Denny, WA; Gamage, SA; Ghoshal, K; Jacob, ST; Phiasivongsa, P; Redkar, S	1
Guo, H; Li, X; Lin, X; Wang, J; Wu, Q	1
Chen, WN; Feng, H; Niu, D; Sui, J; Zhang, J	1
Hu, WY; Li, X; Li, XP; Ren, H; Shen, W; Tang, KF; Tian, L; Wang, F; Wu, JF; Yang, M; Zeng, GL	1
Wu, Y; Xiao, WH	1
Beedanagari, SR; Hankinson, O; Taylor, RT	1
Huang, AL; Li, XP; Yang, M	1
Kang, HR; Li, QW; Sanren, GW; Song, LP; Wang, RL; Xiao, WH; Ye, M; Zhu, JH	1
Han, B; Li, H; Liu, W; Wang, Y; Zhang, C; Zhang, Q; Zhang, T; Zhang, X; Zhou, G	1
Jang, JJ; Kang, GH; Kim, BH; Shin, SH; Suh, KS	1
Breinig, M; Breuhahn, K; Dutruel, C; Gdynia, G; Goeppert, B; Kern, MA; Longerich, T; Mehrabi, A; Mittelbronn, M; Oakes, C; Penzel, R; Plass, C; Popanda, O; Renner, M; Schirmacher, P; Schmezer, P; Vogel, MN; Warth, A	1
Berger, A; Bitzer, M; Fulda, S; Gregor, M; Häcker, S; Königsrainer, A; Lauer, UM; Peter, C; Venturelli, S; Weiland, T; Weiss, TS; Wesselborg, S; Zimmermann, M	1
Cho, YK; Jin, W; Kim, HP; Kim, MS; Lee, JJ; Son, BH	1
Li, M; Li, XH; Sun, JZ; Wang, Y; Xu, WW; Yang, XX; Zhu, W	1
Acun, T; Oztas, E; Yagci, T; Yakicier, MC	1
Bhattacharyya, B; Hallett, M; Han, ZG; Huang, J; Stefanska, B; Suderman, M; Szyf, M	1
Hao, T; Li, S; Li, Z; Yang, J; Zhang, H	1
Cui, Y; Gu, J; Guo, S; He, Y; Luo, X; Ma, K; Wang, W	1
Jung, G; Lim, SO; Quan, X	1
Fujii, T; Hayashi, M; Kanda, M; Kodera, Y; Nishikawa, Y; Nomoto, S; Okamura, Y; Sugimoto, H; Takeda, S; Yamada, S	1
Cao, J; Fang, S; Huang, SF; Ren, GS; Wen, YA; Zhang, LP	1
Bai, T; Bai, Y; Du, Z; Gao, YT; Lou, C; Wang, FM; Wang, YJ; Yang, B; Zhang, Y	1
Guo, XL; Li, R; Song, JR; Tao, SF; Wei, LX; Wu, MC; Xu, Y; Zhang, CS; Zhang, SS	1
Aransay, AM; Aspichueta, P; Beraza, N; Calvisi, DF; Evert, M; Fernández-Ramos, D; García-Rodríguez, JL; Gutiérrez, V; Lozano, JJ; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-López, N; Mato, JM; Schlangen, K; Varela-Rey, M; Wagner, C	1
Ehemann, V; Geffers, R; Hoffmann, K; Kesselmeier, M; Longerich, T; Lorenzo Bermejo, J; Neumann, O; Pellegrino, R; Radlwimmer, B; Schemmer, P; Schirmacher, P	1
Du, HY; Li, FX; Li, M; Li, XH; Sun, JZ; Wu, YS; Yang, XX; Zhu, W	1
Jang, JJ; Jung, N; Kang, GH; Kim, BH; Suh, KS; Won, JK	1
Fan, L; Fan, T; Gao, L; Li, R; Ling, Y; Wei, L; Wu, D; Zhang, C; Zhu, J	1
D'Alessandro, N; Labbozzetta, M; Notarbartolo, M; Poma, P; Porcasi, R; Vivona, N	1
Chen, F; Fei, QL; Han, ZG; Huang, J; Li, YD; Liu, RF; Xu, X	1
Durkin, ME; Popescu, NC; Yuan, BZ	1
Ching, YP; Jin, DY; Lee, JM; Ng, IO; Wong, CM	1
Baumann, H; Blanchard, F; Chattopadhyay, S; Held, WA; Smith, J; Tracy, E; Wang, Y	1
Chiba, T; Fukai, K; Hirasawa, Y; Imazeki, F; Kataoka, H; Saisho, H; Tada, M; Yokosuka, O	1
Fu, HY; Hori, M; Kawano, S; Murata, H; Sakaguchi, Y; Tsuji, S; Tsujii, M	1
Jin, B; Kim, G; Park, DW; Ryu, DY	1
Kubo, T; Matsubara, K; Niwa, Y; Shikauchi, Y; Yamamoto, J; Yoshikawa, H	1
Gu, J; Li, J; Lin, S; Lu, W; Wang, Y; Yu, J; Zhang, H; Zhu, J	1
Li, HM; Liew, CT; Suen, KW; Yau, LM; Yu, F; Zhang, CJ; Zhou, GY	1
Chu, PG; Chung, C; Liu, X; Lopez, R; Qiu, W; Shih, J; Yen, Y; Zhou, B; Zou, H	1
Ezaki, T; Inoue, H; Mimori, K; Mori, M; Ogawa, K; Ohta, M; Utsunomiya, T; Yamashita, K; Yoshikawa, Y; Yoshinaga, K	1
Hwang, EH; Kim, JH; Paik, YK; Park, HJ; Shim, YH	1
Imazeki, F; Kanda, T; Nagao, K; Saisho, H; Tada, M; Yokosuka, O	1
Cho, YG; Kim, CJ; Kim, SY; Lee, JY; Lee, SH; Lee, YS; Nam, SW; Park, WS; Song, JH; Yoo, NJ	1
Chen, W; Jiang, B; Jiang, JD; Liu, H; Liu, J; Liu, W; Luo, C; Wang, L; Wu, Y; Xue, R; Zhao, W; Zhou, Y	1
Arai, M; Chiba, T; Fukai, K; Hirasawa, Y; Imazeki, F; Kanda, T; Ochiai, T; Saisho, H; Seki, N; Takiguchi, Y; Yatomi, M; Yokosuka, O	1
Chen, HJ; Dannenberg, LO; Edenberg, HJ; Tian, H	1
Dannenberg, LO; Edenberg, HJ	1
Arai, M; Fukai, K; Hirasawa, Y; Imazeki, F; Mikata, R; Miyazaki, M; Ochiai, T; Saisho, H; Tada, M; Yokosuka, O	1
Armeanu, S; Bitzer, M; Gregor, M; Hsieh, CJ; Lauer, UM; Pathil, A; Venturelli, S; Vonthein, R; Wehrmann, M; Weiss, TS	1
Dou, KF; Zhao, QZ	1
Chan, CY; Cheung, OF; Ching, YP; Lee, JM; Ng, IO; Ng, YL; Tung, EK; Wong, CC; Wong, CM	1
Hou, J; Li, H; Li, J; Liew, CT; Yin, D; Zhang, C; Zhang, J; Zhang, Q; Zhang, T; Zhou, G	1
Imreh, S; Klein, G; Popescu, NC; Zhou, X	1
Cheng, YC; Fan, H; Lu, ZH; Shan, YF; Xie, W; Zhang, JQ; Zhao, ZJ	1
Chen, XP; Gutmann, DH; Huang, ZY; Xiao, ZY; Xiong, M; Yan, Q; Zhang, ZF	1
Bahendeka, S; Katongole-Mbidde, E; Kyalwazi, SK; Mugerwa, J; Olweny, CL; Otim, D	1
Bagnis, C; Bréchot, C; Chapel, S; Gerolami, R; Jordier, F; Mannoni, P; Uch, R	1
Endo, T; Iku, S; Imai, K; Itoh, F; Iwata, N; Kaneto, H; Karino, Y; Kikuchi, T; Ozeki, I; Sasaki, S; Satoh, M; Satoh, T; Suzuki, H; Toyota, J; Yamamoto, H	1
Baek, WK; Carson, DA; Cho, JW; Kwon, T; Park, JB; Park, JW; Pyun, HY; Suh, MH; Suh, SI	1
Filmus, J; Ladeda, V; Xiang, YY	1
Fujikawa, T; Hanafusa, T; Higashi, T; Nakamura, S; Nakatsukasa, H; Nouso, K; Onishi, T; Takuma, Y; Taniyama, M; Tsuji, T; Uemura, M; Yumoto, E; Yumoto, Y	1
Liu, LH; Liu, WW; Xiao, WH	1
Johnson, PJ; Liu, C; Lo, YM; Tang, MW; Yeo, W; Zhong, S	1
Borsos, T; Ohanian, SH; Segerling, M	3
Pitot, HC; Weiss, JW	3
Billmire, DF; Keefer, RC; MacNamara, DJ; Schumm, DE; Webb, TE	1
Greenberg, N; Hurtubise, PE; Schumm, DE; Webb, TE	1
Abraham, D; Behrens, M; Plagemann, PG	1
Beitel, G; Foster, R; Gedamu, L; Jahroudi, N; Price-Haughey, J	1
Alexander, JJ; Aspinall, S	1
Fukusato, T; Gerber, MA; Mohamad, A; Thung, SN	1
Cavia, E; Webb, TE	1
Martin, DW; Owen, NT	1
Keefer, RC; Morris, HP; Webb, TE	1
Cihák, A; Pitot, HC; Weiss, JW	1

Trials

1 trial(s) available for azacitidine and Hepatocellular Carcinoma

Article	Year
An open-label, single-arm, phase I/II study of lower-dose decitabine based therapy in patients with advanced hepatocellular carcinoma. Oncotarget, 2015, Jun-30, Volume: 6, Issue:18 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Hepatocellular; Decitabine; Disease-Free Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Modification Methylases; Female; Humans; Liver Neoplasms; Male; Middle Aged; Treatment Outcome	2015

Article

Year

An open-label, single-arm, phase I/II study of lower-dose decitabine based therapy in patients with advanced hepatocellular carcinoma.

Oncotarget, 2015, Jun-30, Volume: 6, Issue:18

Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Hepatocellular; Decitabine; Disease-Free Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Modification Methylases; Female; Humans; Liver Neoplasms; Male; Middle Aged; Treatment Outcome

2015

Other Studies

116 other study(ies) available for azacitidine and Hepatocellular Carcinoma

Article	Year
Methylation‑associated inactivation of JPH3 and its effect on prognosis and cell biological function in HCC. Molecular medicine reports, 2022, Volume: 25, Issue:4 Topics: Adult; Aged; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line; Cell Movement; Cell Proliferation; CpG Islands; DNA Methylation; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Membrane Proteins; Middle Aged; Prognosis; Promoter Regions, Genetic	2022
5-Azacytidine promotes HCC cell metastasis by up-regulating RDH16 expression. European journal of pharmacology, 2023, Jul-05, Volume: 950 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methyltransferases; Neoplasm Metastasis	2023
PD-L1 Downregulation and DNA Methylation Inhibition for Molecular Therapy against Cancer Stem Cells in Hepatocellular Carcinoma. International journal of molecular sciences, 2023, Aug-29, Volume: 24, Issue:17 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; DNA Methylation; Down-Regulation; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL	2023
DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer. Clinical epigenetics, 2020, 02-14, Volume: 12, Issue:1 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Circulating Tumor DNA; DNA Methylation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Protein Kinase Inhibitors; Sorafenib	2020
OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma. Carcinogenesis, 2017, 09-01, Volume: 38, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Azacitidine; Biopsy; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Down-Regulation; Female; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; RNA, Messenger	2017
Expression of delta-like 3 is downregulated by aberrant DNA methylation and histone modification in hepatocellular carcinoma. Oncology reports, 2018, Volume: 39, Issue:5 Topics: Acetylation; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic	2018
Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells. Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 07-05, Volume: 26, Issue:7 Topics: Animals; Azacitidine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocytes; Humans; Liver; Liver Neoplasms; Mice; Mice, Nude	2018
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma. Hepatology (Baltimore, Md.), 2018, Volume: 68, Issue:4 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methyltransferases; Molecular Targeted Therapy; Sensitivity and Specificity	2018
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma. Journal of experimental & clinical cancer research : CR, 2018, Jul-31, Volume: 37, Issue:1 Topics: AC133 Antigen; Animals; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Gene Knockdown Techniques; Humans; Hyaluronan Receptors; Liver Neoplasms; Mice; Mice, Inbred NOD; Neoplastic Stem Cells; Osteopontin; Transfection; Up-Regulation; Xenograft Model Antitumor Assays	2018
A Three-Pronged Epigenetic Approach to the Treatment of Hepatocellular Carcinoma. Hepatology (Baltimore, Md.), 2018, Volume: 68, Issue:4 Topics: Azacitidine; Carcinoma, Hepatocellular; DNA; Humans; Liver Neoplasms; Methyltransferases	2018
Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma. Epigenetics, 2013, Volume: 8, Issue:4 Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Apoptosis; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Decitabine; Epigenesis, Genetic; Female; G2 Phase Cell Cycle Checkpoints; Heterografts; Humans; Liver Neoplasms; Male; Methylation; Mice, Nude; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Transcription Factor 4; Transcription Factors; Wnt Signaling Pathway	2013
Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells. Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:5 Topics: Azacitidine; Carcinoma, Hepatocellular; Decitabine; Epigenesis, Genetic; Hep G2 Cells; Hepatitis C; Humans; Liver Neoplasms; Methyltransferases; MicroRNAs; Phenylbutyrates; PPAR gamma; Promoter Regions, Genetic; Repressor Proteins; Trans-Activators; Viral Regulatory and Accessory Proteins	2013
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. Oncogene, 2014, May-29, Volume: 33, Issue:22 Topics: Acetylation; Animals; Azacitidine; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Histones; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Tumor Burden; Viral Core Proteins; Wnt Proteins; Xenograft Model Antitumor Assays	2014
Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative response in human hepatocellular carcinoma. Hepatology (Baltimore, Md.), 2013, Volume: 58, Issue:6 Topics: Adolescent; Adult; Aged; Azacitidine; Carcinoma, Hepatocellular; DNA Methylation; Eye Proteins; Female; Fluorouracil; Gene Silencing; Humans; Liver Neoplasms; Male; Middle Aged; Signal Transduction; Transcription Factors; Transforming Growth Factor beta1; Tumor Suppressor Proteins	2013
[The methylation of ZHX2 gene promoter enhances AFP gene expression in hepatocellular carcinoma]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013, Volume: 29, Issue:7 Topics: alpha-Fetoproteins; Azacitidine; Carcinoma, Hepatocellular; DNA Methylation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Homeodomain Proteins; Humans; Liver Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors	2013
Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells. Genetics and molecular research : GMR, 2013, Sep-13, Volume: 12, Issue:3 Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver; Liver Neoplasms; MicroRNAs; Promoter Regions, Genetic	2013
5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production. Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:11 Topics: Apoptosis; Azacitidine; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methionine Adenosyltransferase; Proto-Oncogene Proteins c-bcl-2; S-Adenosylmethionine; Up-Regulation	2013
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis. International journal of oncology, 2014, Volume: 44, Issue:6 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; MicroRNAs; Promoter Regions, Genetic	2014
Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking. Digestive diseases (Basel, Switzerland), 2014, Volume: 32, Issue:6 Topics: Aged; Azacitidine; Biopsy, Needle; Carcinoma, Hepatocellular; Case-Control Studies; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Liver Neoplasms; Male; Middle Aged; Reference Values; Sampling Studies; Tumor Cells, Cultured	2014
MiR-376a and histone deacetylation 9 form a regulatory circuitry in hepatocellular carcinoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:2 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Histone Deacetylases; Humans; Liver Neoplasms; MicroRNAs; Mutation; Repressor Proteins	2015
PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas. Omics : a journal of integrative biology, 2015, Volume: 19, Issue:4 Topics: Azacitidine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Homozygote; Humans; Hydroxamic Acids; Liver Neoplasms; Microarray Analysis; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Sequence Deletion	2015
Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective. Molecular and cellular biochemistry, 2015, Volume: 405, Issue:1-2 Topics: Alendronate; Apoptosis; Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Drug Therapy, Combination; Humans; Liver Neoplasms; Proteome; Proteomics; Up-Regulation	2015
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU. Oncotarget, 2015, May-10, Volume: 6, Issue:13 Topics: Aged; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Early Growth Response Protein 1; Enzyme Inhibitors; Female; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Silencing; Hep G2 Cells; Humans; Liver Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Protein p53	2015
Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Molecular oncology, 2015, Volume: 9, Issue:9 Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Liver; Liver Neoplasms; Mice; Organoplatinum Compounds; Oxaliplatin; Signal Transduction; Survivin; Wnt3A Protein	2015
Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells. The international journal of biochemistry & cell biology, 2015, Volume: 68 Topics: Acetylcholinesterase; Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cisplatin; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Liver Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; RNA, Small Interfering; Signal Transduction	2015
HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells. Molecular cancer therapeutics, 2015, Volume: 14, Issue:11 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Blotting, Western; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-delta; Cell Line, Tumor; Cells, Cultured; Decitabine; E2F1 Transcription Factor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Immunohistochemistry; Ketones; Liver Neoplasms; Mice, Inbred NOD; Mice, SCID; Oligonucleotide Array Sequence Analysis; Propane; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Burden; Xenograft Model Antitumor Assays	2015
The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells. International journal of oncology, 2016, Volume: 48, Issue:1 Topics: Adenosine; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Proliferation; CpG Islands; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Neoplasm Proteins; Promoter Regions, Genetic; RNA, Long Noncoding	2016
DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Cancer research, 2016, Feb-01, Volume: 76, Issue:3 Topics: Adult; Aged, 80 and over; Animals; Azacitidine; beta-Galactosidase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Senescence; Disease Progression; DNA Methylation; Epigenomics; Gene Expression; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Isoforms	2016
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7. Clinical epigenetics, 2016, Volume: 8 Topics: Ascorbic Acid; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Methylation; Drug Synergism; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms	2016
Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP). Cellular signalling, 2016, Volume: 28, Issue:12 Topics: Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Ki-67 Antigen; Liver Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; RNA, Messenger; Treatment Outcome; Tristetraprolin	2016
Clinical and biological significance of miR-23b and miR-193a in human hepatocellular carcinoma. Oncotarget, 2017, Jan-24, Volume: 8, Issue:4 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Disease-Free Survival; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; MicroRNAs	2017
Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells. International journal of cancer, 2008, Sep-01, Volume: 123, Issue:5 Topics: Acetylation; Adult; Aged; Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Loss of Heterozygosity; Male; Middle Aged; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation	2008
Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jun-15, Volume: 14, Issue:12 Topics: Aged; Azacitidine; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Epistasis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hepatoblastoma; Humans; Liver Neoplasms; Loss of Heterozygosity; Male; Membrane Glycoproteins; Middle Aged; Veratrum Alkaloids	2008
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:2 Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Caspases; Cell Division; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; Digestive System Neoplasms; DNA Methylation; Epigenesis, Genetic; G2 Phase; Gene Silencing; Humans; Hydroxamic Acids; Liver Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin Thiolesterase	2008
Predictive value of expression and promoter hypermethylation of XAF1 in hepatitis B virus-associated hepatocellular carcinoma treated with transplantation. Annals of surgical oncology, 2008, Volume: 15, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis Regulatory Proteins; Azacitidine; Carcinoma, Hepatocellular; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Hepatitis B; Hepatitis B virus; Humans; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Neoplasm Proteins; Neoplasm Recurrence, Local; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Survival Rate; Tumor Cells, Cultured; Zinc Fingers	2008
Epigenetic inactivation of SLIT2 in human hepatocellular carcinomas. Biochemical and biophysical research communications, 2009, Jan-30, Volume: 379, Issue:1 Topics: Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Nerve Tissue Proteins; Promoter Regions, Genetic	2009
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer research, 2009, May-15, Volume: 69, Issue:10 Topics: Animals; Azacitidine; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Modification Methylases; Female; Gene Silencing; Genes, Tumor Suppressor; HeLa Cells; Humans; Liver Neoplasms; Mice; Quinolines; Reverse Transcriptase Polymerase Chain Reaction	2009
Fabrication of novel hepatoma-targeting microdisks by hydrogen bond-assisted self-assembly of an azacitidine-conjugating amphiphilic random copolymer. Acta biomaterialia, 2010, Volume: 6, Issue:2 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Humans; Hydrogen Bonding; Liver Neoplasms; Microscopy, Electron; Spectrum Analysis	2010
iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile associated with HBV-modulated DNA methylation. Proteomics, 2009, Volume: 9, Issue:15 Topics: Azacitidine; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromatography, Liquid; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Hepatitis B virus; Humans; Liver Neoplasms; Proteome; Reverse Transcriptase Polymerase Chain Reaction; Tandem Mass Spectrometry	2009
[Up-regulation of major histocompatibility complex class I-related molecules A (MICA) induced by 5-aza-2'-deoxycytidine]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2009, Volume: 17, Issue:9 Topics: Ataxia Telangiectasia Mutated Proteins; Azacitidine; Caffeine; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line; Cell Membrane; Decitabine; DNA Damage; DNA-Binding Proteins; Flow Cytometry; Hep G2 Cells; Hepatocytes; Histocompatibility Antigens Class I; Humans; Liver Neoplasms; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Suppressor Proteins; Up-Regulation	2009
[Effects of 5-aza-2'-deoxycytidine on the amount of exosomes and secreted immuno-associated proteins by hepatoma cells]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2009, Volume: 31, Issue:7 Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA Modification Methylases; Exosomes; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histocompatibility Antigens Class I; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Membrane Proteins; RNA, Messenger; Tumor Suppressor Protein p53; Up-Regulation	2009
Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. Toxicology letters, 2010, Apr-15, Volume: 194, Issue:1-2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Decitabine; Dioxins; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Enzymologic; Hybrid Cells; Hydroxamic Acids; Liver Neoplasms; Mice; Receptors, Aryl Hydrocarbon; RNA, Messenger	2010
[No correlation between the sensitivity to 5-aza-dC and the global DNA methylation level in hepatocellular carcinoma cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:4 Topics: Azacitidine; Carcinoma, Hepatocellular; Caspase 3; Decitabine; DNA Methylation; DNA Modification Methylases; Hep G2 Cells; Humans	2010
Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma. World journal of gastroenterology, 2010, May-21, Volume: 16, Issue:19 Topics: Antigens, Neoplasm; Azacitidine; Blotting, Western; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Exosomes; Hep G2 Cells; HLA Antigens; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Membrane Proteins; Microscopy, Immunoelectron; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p53; Up-Regulation	2010
Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications. Journal of hepatology, 2010, Volume: 53, Issue:5 Topics: Acetylation; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Nuclear Proteins; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors	2010
Identification of novel methylation markers in hepatocellular carcinoma using a methylation array. Journal of Korean medical science, 2010, Volume: 25, Issue:8 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Profiling; GPI-Linked Proteins; Homeodomain Proteins; Humans; Interferon Regulatory Factors; Liver Neoplasms; Neuropeptide Y; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor, Member 10c; Tumor Necrosis Factor Decoy Receptors	2010
Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms. Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:6 Topics: A Kinase Anchor Proteins; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Humans; Liver Neoplasms; MicroRNAs; Promoter Regions, Genetic; Protein Array Analysis	2010
Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation. Gut, 2011, Volume: 60, Issue:2 Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Cell Proliferation; DNA Methylation; DNA, Neoplasm; Down-Regulation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Enzyme Activation; Epigenesis, Genetic; Humans; Liver Neoplasms; Neoplasm Proteins; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured	2011
DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma. Biochemical and biophysical research communications, 2011, Mar-04, Volume: 406, Issue:1 Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Receptor, trkA; Receptor, trkB; Receptor, trkC; Receptors, Nerve Growth Factor; Twist-Related Protein 1	2011
Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma. Digestive diseases and sciences, 2011, Volume: 56, Issue:10 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Middle Aged; Octamer Transcription Factor-6; RNA, Messenger	2011
SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation. BMC cancer, 2011, Jun-06, Volume: 11 Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Promoter Regions, Genetic; Repressor Proteins; Restriction Mapping; Transcription, Genetic; Young Adult; Zinc Finger E-box Binding Homeobox 2	2011
Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer research, 2011, Sep-01, Volume: 71, Issue:17 Topics: Aged; Azacitidine; Breast Neoplasms; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Ovarian Neoplasms; Promoter Regions, Genetic	2011
Promoter hypermethylation of DNA damage response genes in hepatocellular carcinoma. Cell biology international, 2012, May-01, Volume: 36, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; CpG Islands; Decitabine; DNA Damage; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Hep G2 Cells; Humans; Liver Neoplasms; Male; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Poly-ADP-Ribose Binding Proteins; Prognosis; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases	2012
Hypomethylation of the hsa-miR-191 locus causes high expression of hsa-mir-191 and promotes the epithelial-to-mesenchymal transition in hepatocellular carcinoma. Neoplasia (New York, N.Y.), 2011, Volume: 13, Issue:9 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; DNA Methylation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; Neoplasm Invasiveness; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-3	2011
Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter. FEBS letters, 2011, Nov-04, Volume: 585, Issue:21 Topics: Acetylcysteine; Azacitidine; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Invasiveness; Octamer Transcription Factor-1; Promoter Regions, Genetic; Reactive Oxygen Species	2011
Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma. Journal of surgical oncology, 2012, Mar-15, Volume: 105, Issue:4 Topics: A Kinase Anchor Proteins; Adult; Aged; Apoptosis; Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Immunoenzyme Techniques; Liver Neoplasms; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate	2012
Silencing of PCDH10 in hepatocellular carcinoma via de novo DNA methylation independent of HBV infection or HBX expression. Clinical and experimental medicine, 2013, Volume: 13, Issue:2 Topics: Azacitidine; Cadherins; Carcinoma, Hepatocellular; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Hep G2 Cells; Hepatitis B virus; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; Protocadherins; RNA, Messenger; Trans-Activators; Viral Regulatory and Accessory Proteins	2013
Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication. World journal of gastroenterology, 2012, May-07, Volume: 18, Issue:17 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; Humans; Liver Neoplasms; Osteonectin; Prognosis; RNA, Messenger	2012
Anti-tumor effect of 5-aza-2'-deoxycytidine by inhibiting telomerase activity in hepatocellular carcinoma cells. World journal of gastroenterology, 2012, May-21, Volume: 18, Issue:19 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Expression; Humans; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Telomerase	2012
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. Gastroenterology, 2012, Volume: 143, Issue:3 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; DNA Methylation; Enzyme Activation; Enzyme Inhibitors; Glycine N-Methyltransferase; Guanine Nucleotide Exchange Factors; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; ras Guanine Nucleotide Exchange Factors; ras Proteins; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden	2012
Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:5 Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Blood Proteins; Carcinoma, Hepatocellular; Carrier Proteins; Case-Control Studies; Cell Line, Tumor; Comparative Genomic Hybridization; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Female; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Period Circadian Proteins; Promoter Regions, Genetic; Young Adult	2012
Aberrant methylation and downregulation of sall3 in human hepatocellular carcinoma. World journal of gastroenterology, 2012, Jun-07, Volume: 18, Issue:21 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Liver Neoplasms; Models, Genetic; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors; Transcription, Genetic	2012
Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma. Journal of Korean medical science, 2012, Volume: 27, Issue:6 Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Female; Hep G2 Cells; Humans; Hydroxamic Acids; Liver; Liver Neoplasms; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Survival Analysis	2012
Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure. Cell biochemistry and biophysics, 2013, Volume: 65, Issue:2 Topics: Adult; Aged; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Histone Deacetylase Inhibitors; Host-Pathogen Interactions; Humans; Hydrolases; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Middle Aged; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis	2013
Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma. Omics : a journal of integrative biology, 2012, Volume: 16, Issue:11 Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Leupeptins; Liver Neoplasms; MicroRNAs; Mutation; Phosphatidylethanolamine Binding Protein; Promoter Regions, Genetic; RNA Interference	2012
Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. Cancer letters, 2013, Feb-28, Volume: 329, Issue:2 Topics: Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Modification Methylases; Down-Regulation; Focal Adhesion Kinase 2; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; MicroRNAs; Multigene Family; Oligonucleotide Array Sequence Analysis; RNA Interference; Transcriptome	2013
Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer genetics and cytogenetics, 2003, Jan-15, Volume: 140, Issue:2 Topics: Adenocarcinoma; Azacitidine; Base Sequence; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; GTPase-Activating Proteins; Humans; Liver Neoplasms; Male; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins	2003
Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer research, 2003, Nov-15, Volume: 63, Issue:22 Topics: Azacitidine; Base Sequence; Carcinoma, Hepatocellular; cdc42 GTP-Binding Protein; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; GTPase-Activating Proteins; Humans; Liver Neoplasms; Loss of Heterozygosity; Molecular Sequence Data; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; RNA, Messenger; Tumor Suppressor Proteins	2003
DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor. Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:6 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA-Binding Proteins; Interleukin-6; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Liver Neoplasms; Promoter Regions, Genetic; Rats; Receptors, Cytokine; Receptors, OSM-LIF; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Trans-Activators	2003
Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma. Cancer research, 2003, Dec-15, Volume: 63, Issue:24 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Liver Neoplasms; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Trypsin Inhibitor, Kunitz Soybean	2003
Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. Laboratory investigation; a journal of technical methods and pathology, 2004, Volume: 84, Issue:8 Topics: Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Decitabine; Dinoprostone; DNA Methylation; DNA, Neoplasm; Gene Silencing; Humans; Isoenzymes; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases	2004
Microarray analysis of gene regulation in the Hepa1c1c7 cell line following exposure to the DNA methylation inhibitor 5-aza-2'-deoxycytidine and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology in vitro : an international journal published in association with BIBRA, 2004, Volume: 18, Issue:5 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Mice; Oligonucleotide Array Sequence Analysis; Polychlorinated Dibenzodioxins	2004
Apoptotic speck protein-like, a highly homologous protein to apoptotic speck protein in the pyrin domain, is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma. Cancer research, 2004, Aug-01, Volume: 64, Issue:15 Topics: Amino Acid Sequence; Annexin A5; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; CARD Signaling Adaptor Proteins; Caspase 3; Caspases; Cytoskeletal Proteins; Decitabine; DNA Methylation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Liver Neoplasms; Molecular Sequence Data; Protein Structure, Tertiary; Proteins; Pyrin; Sequence Homology, Amino Acid; Tumor Cells, Cultured	2004
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. BMC cancer, 2004, Sep-14, Volume: 4 Topics: Adolescent; Adult; Antigens, Neoplasm; Astrocytoma; Azacitidine; Brain Neoplasms; Cadherins; Carcinoma, Hepatocellular; Child; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Genes, Tumor Suppressor; Glioma; Humans; Liver Neoplasms; Male; Melanoma-Specific Antigens; Middle Aged; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Sex Factors; Tumor Cells, Cultured; Tumor Protein p73; Tumor Suppressor Proteins	2004
[Methylation of mismatch repair gene (MMR) in primary hepatocellular carcinoma]. Zhonghua bing li xue za zhi = Chinese journal of pathology, 2004, Volume: 33, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Base Pair Mismatch; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MutL Protein Homolog 1; MutL Proteins; Neoplasm Proteins; Nuclear Proteins; RNA, Messenger	2004
Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. The American journal of pathology, 2004, Volume: 165, Issue:5 Topics: Apoptosis; Azacitidine; Binding Sites; Blotting, Northern; Carcinoma, Hepatocellular; Cell Line, Tumor; Cloning, Molecular; CpG Islands; Decitabine; DNA; DNA Damage; DNA Methylation; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; GADD45 Proteins; Genes, p53; Genes, Reporter; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Liver; Liver Neoplasms; Luciferases; Mutation; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Sulfites; Transfection; Tumor Suppressor Protein p53	2004
Clinicopathologic and prognostic values of apolipoprotein D alterations in hepatocellular carcinoma. International journal of cancer, 2005, Aug-10, Volume: 116, Issue:1 Topics: Aged; Apolipoproteins; Apolipoproteins D; Azacitidine; Carcinoma, Hepatocellular; DNA Methylation; Female; Gene Silencing; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Cells, Cultured	2005
Methylation of CpG islands in the rat 7-dehydrocholesterol reductase promoter suppresses transcriptional activation. Molecules and cells, 2005, Apr-30, Volume: 19, Issue:2 Topics: Animals; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Enzymologic; Gene Silencing; Humans; Liver Neoplasms; Luciferases; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Promoter Regions, Genetic; Rats; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured	2005
5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines. Oncology reports, 2005, Volume: 14, Issue:4 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Decitabine; DNA; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorouracil; HeLa Cells; Humans; Liver Neoplasms; Pancreatic Neoplasms; Prognosis; Time Factors; Treatment Outcome; Trypan Blue	2005
Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. Experimental & molecular medicine, 2005, Aug-31, Volume: 37, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Humans; Liver Neoplasms; Male; Middle Aged; Promoter Regions, Genetic	2005
Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration. International journal of oncology, 2006, Volume: 28, Issue:5 Topics: Adult; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; gamma-Synuclein; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Staging	2006
Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-2'-deoxycytidine. Cancer, 2006, Jun-01, Volume: 106, Issue:11 Topics: Azacitidine; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Proteins; Tumor Cells, Cultured	2006
Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. Alcoholism, clinical and experimental research, 2006, Volume: 30, Issue:6 Topics: Alcohol Dehydrogenase; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Liver Neoplasms; Promoter Regions, Genetic	2006
Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC genomics, 2006, Jul-19, Volume: 7 Topics: Acetylation; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cluster Analysis; DNA Methylation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Liver; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction	2006
Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. Oncology, 2006, Volume: 71, Issue:1-2 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Carrier Proteins; Caveolin 1; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 6; Kruppel-Like Transcription Factors; LIM Domain Proteins; Liver Neoplasms; Microfilament Proteins; Muscle Proteins; Myosin Light Chains; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction	2006
Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma. Cancer, 2007, May-15, Volume: 109, Issue:10 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Vorinostat	2007
Methylation of Ras association domain family protein 1, isoform A correlated with proliferation and drug resistance in hepatocellular carcinoma cell line SMMC-7721. Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:5 Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Neoplastic Stem Cells; Transfection; Tumor Suppressor Proteins	2007
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:5 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic; Serine Proteinase Inhibitors	2007
Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells. The Journal of pathology, 2007, Volume: 212, Issue:2 Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Methylation; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic	2007
The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. Cancer genetics and cytogenetics, 2007, Volume: 177, Issue:1 Topics: Amino Acid Sequence; Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Interferon-alpha; Liver Neoplasms; Male; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Sequence Homology, Amino Acid	2007
Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chinese medical journal, 2007, Sep-20, Volume: 120, Issue:18 Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; CpG Islands; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Transcriptional Activation	2007
Reduced T-cadherin expression and promoter methylation are associated with the development and progression of hepatocellular carcinoma. International journal of oncology, 2008, Volume: 32, Issue:5 Topics: Adult; Aged; Azacitidine; Cadherins; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Tumor Suppressor Proteins	2008
Further experience in treating patients with hepatocellular carcinoma in Uganda. Cancer, 1980, Dec-15, Volume: 46, Issue:12 Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Azacitidine; Carcinoma, Hepatocellular; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Hepatic Artery; Humans; Injections, Intravenous; Ligation; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pigmentation Disorders; Razoxane; Uganda	1980
Gene transfer to hepatocellular carcinoma: transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors. Cancer gene therapy, 2000, Volume: 7, Issue:9 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Survival; Dexamethasone; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins; HIV; Humans; Interleukin-6; Ionomycin; Kinetics; Leukemia Virus, Murine; Liver Neoplasms; Luminescent Proteins; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transduction, Genetic; Transgenes; Tumor Cells, Cultured	2000
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma. Oncogene, 2000, Nov-02, Volume: 19, Issue:46 Topics: 14-3-3 Proteins; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; CpG Islands; Cytidine Triphosphate; Cytoplasm; DNA Methylation; DNA Mutational Analysis; Gene Silencing; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Polymorphism, Single-Stranded Conformational; Sulfites; Tyrosine 3-Monooxygenase	2000
5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. Cancer letters, 2000, Nov-10, Volume: 160, Issue:1 Topics: Azacitidine; Base Sequence; Blotting, Western; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Down-Regulation; Humans; Jurkat Cells; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Retinoblastoma Protein; RNA, Neoplasm; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured	2000
Glypican-3 expression is silenced in human breast cancer. Oncogene, 2001, Nov-01, Volume: 20, Issue:50 Topics: Azacitidine; Breast; Breast Neoplasms; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA, Neoplasm; Dosage Compensation, Genetic; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Glypicans; Heparan Sulfate Proteoglycans; Humans; Liver Neoplasms; Loss of Heterozygosity; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Tumor Stem Cell Assay; X Chromosome	2001
Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma. Cancer letters, 2002, Feb-25, Volume: 176, Issue:2 Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Blotting, Northern; Carcinoma, Hepatocellular; Chromosomes, Human, Pair 7; Decitabine; DNA Methylation; DNA, Complementary; Humans; Insulin-Like Growth Factor Binding Protein 3; Liver Neoplasms; Loss of Heterozygosity; Mannosephosphates; Molecular Sequence Data; Mutation; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Receptor, IGF Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tumor Cells, Cultured	2002
Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2. World journal of gastroenterology, 2001, Volume: 7, Issue:1 Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinogenicity Tests; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; RNA, Messenger; Tumor Cells, Cultured	2001
Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:4 Topics: Adult; Azacitidine; Blotting, Western; Carcinoma, Hepatocellular; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Glutathione Transferase; Hepatitis B; Humans; Isoenzymes; Liver Neoplasms; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured	2002
Chemotherapeutic drugs increase killing of tumor cells by antibody and complement. Science (New York, N.Y.), 1975, Apr-04, Volume: 188, Issue:4183 Topics: Animals; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Complement System Proteins; Cyclophosphamide; Cytarabine; Fluorouracil; Guinea Pigs; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Nitrosamines; Vincristine	1975
Effects of 5-azacytidine on nucleolar RNA and the preribosomal particles in Novikoff hepatoma cells. Biochemistry, 1975, Jan-28, Volume: 14, Issue:2 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Nucleolus; Cells, Cultured; Guanosine Triphosphate; Liver Neoplasms; Neoplasms, Experimental; Rats; Ribosomes; RNA, Neoplasm; RNA, Ribosomal	1975
Early temporal changes in the uridine kinase isozyme profile of the Novikoff hepatoma in response to 5-azacytidine treatment. Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14 Topics: Aging; Animals; Azacitidine; Carcinoma, Hepatocellular; DNA Replication; Dose-Response Relationship, Drug; Drug Resistance; Female; Isoenzymes; Liver Neoplasms; Neoplasms, Experimental; Phosphotransferases; Rats; Thymidine; Time Factors; Tritium; Uridine Kinase	1975
Enhancing effect by metabolic inhibitors on the killing of tumor cells by antibody and complement. Cancer research, 1975, Volume: 35, Issue:11 Pt 1 Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cells, Cultured; Complement System Proteins; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Fluorouracil; Guinea Pigs; Hydroxyurea; Liver Neoplasms; Mercaptopurine; Methotrexate; Mitomycins; Neoplasms, Experimental; Puromycin; Vincristine	1975
Effect of metabolic inhibitors on the ability of tumor cells to express antigen and bind complement components C4 and C3. Cancer research, 1975, Volume: 35, Issue:11 Pt 1 Topics: Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Binding Sites, Antibody; Carcinoma, Hepatocellular; Cell Membrane; Cells, Cultured; Complement C3; Complement C4; Complement System Proteins; Dactinomycin; Doxorubicin; Guinea Pigs; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Puromycin	1975
Uridine kinase activities in normal and neoplastic lymphoid cells. Cancer research, 1977, Volume: 37, Issue:4 Topics: Animals; Azacitidine; B-Lymphocytes; Carcinoma, Hepatocellular; Cats; Enzyme Induction; Humans; Isoenzymes; Leukemia, Experimental; Leukemia, Lymphoid; Liver Neoplasms; Lymphocyte Activation; Lymphocytes; Lymphoma, Non-Hodgkin; Male; Mast-Cell Sarcoma; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Phosphotransferases; Rats; T-Lymphocytes; Uridine Kinase	1977
Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin. Cancer research, 1978, Volume: 38, Issue:8 Topics: Amides; Animals; Antibiotics, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; Cell Division; Cell Survival; Cytidine; DNA, Neoplasm; Drug Synergism; Leukemia, Experimental; Liver Neoplasms; Neoplasm Proteins; Neoplasms, Experimental; Phosphates; Pyrazoles; Ribonucleosides; Ribose; RNA, Neoplasm; Uridine	1978
Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure. The Journal of biological chemistry, 1990, Apr-15, Volume: 265, Issue:11 Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatin; DNA; Gene Expression Regulation; Genes; Humans; Kinetics; Liver Neoplasms; Metallothionein; Methylation; Organ Specificity; Plasmids; Promoter Regions, Genetic; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured	1990
Hepatitis B virus gene expression in two cell lines, one derived from a natural human infection, the other experimentally infected in vitro. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Nov-09, Volume: 68, Issue:10 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Genes, Viral; Hepatitis B Antigens; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; L Cells; Liver Neoplasms; Mice; Transfection	1985
Synergistic effect of 5-azacytidine and gamma-interferon or dimethyl sulfoxide on expression of HLA class I antigens by PLC-PRF-5 cells. The Tohoku journal of experimental medicine, 1988, Volume: 155, Issue:2 Topics: Antibodies, Monoclonal; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Dimethyl Sulfoxide; Drug Synergism; Enzyme-Linked Immunosorbent Assay; HLA Antigens; HLA-D Antigens; Humans; Interferon-gamma; Liver Neoplasms; Recombinant Proteins	1988
Modified induction of ornithine decarboxylase by factors which affect liver regeneration. Biochimica et biophysica acta, 1972, Apr-12, Volume: 262, Issue:4 Topics: Adrenal Glands; Adrenalectomy; Age Factors; Animals; Azacitidine; Azaguanine; Carbon Isotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Cycloheximide; Dactinomycin; DNA; Enzyme Induction; Hepatectomy; Hydrocortisone; Liver; Liver Neoplasms; Liver Regeneration; Male; Ornithine; Rats; Solubility	1972
Repression and derepression of purine biosynthesis in mammalian hepatoma cells in culture. The Journal of biological chemistry, 1972, Sep-10, Volume: 247, Issue:17 Topics: Acyltransferases; Adenine; Animals; Azacitidine; Carbon Isotopes; Carcinoma, Hepatocellular; Clone Cells; Cycloheximide; Dactinomycin; Feedback; Formates; Glycine; Kinetics; Ligases; Liver Neoplasms; Neoplasms, Experimental; Pentosephosphates; Pentosyltransferases; Purines; Rats; Ribonucleotides; Ribose; Tetrahydrofolates; Tritium	1972
Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells. Archives of biochemistry and biophysics, 1974, Volume: 160, Issue:1 Topics: Animals; Azacitidine; Azaguanine; Carcinoma, Hepatocellular; Cells, Cultured; Cytidine; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Guanosine; Isotope Labeling; Liver; Liver Neoplasms; Neoplasms, Experimental; Rats; RNA, Neoplasm; RNA, Ribosomal; Spectrophotometry, Ultraviolet; Time Factors; Tritium; Uridine	1974
5-azacytidine-modified patterns of uridine kinase activities in normal and neoplastic tissues. Cancer research, 1974, Volume: 34, Issue:9 Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Enzyme Induction; Liver; Liver Neoplasms; Male; Mice; Neoplasms, Experimental; Phosphotransferases; Rats; Time Factors	1974
Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidine. Cancer research, 1974, Volume: 34, Issue:11 Topics: Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Fractionation; Cells, Cultured; Cytoplasm; Leucine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Polyribosomes; Rats; RNA, Ribosomal; Time Factors; Tritium	1974
Alteration of ribosomal precursor RNA in Novikoff hepatoma cells by 5-azacytidine. Studies on methylation of 45S and 32S RNA. Archives of biochemistry and biophysics, 1974, Volume: 165, Issue:2 Topics: Animals; Azacitidine; Azaguanine; Carbon Radioisotopes; Carcinoma, Hepatocellular; Electrophoresis, Polyacrylamide Gel; Guanosine; Liver Neoplasms; Methionine; Neoplasms, Experimental; Rats; RNA, Neoplasm; RNA, Ribosomal; Transcription, Genetic; Tritium; Uridine	1974