Compounds > azacitidine

azacitidine and Disease Models, Animal

azacitidine has been researched along with Disease Models, Animal in 119 studies

Research

Studies (119)

TimeframeStudies, this research(%)All Research%
pre-19904 (3.36)18.7374
1990's5 (4.20)18.2507
2000's18 (15.13)29.6817
2010's78 (65.55)24.3611
2020's14 (11.76)2.80

Authors

AuthorsStudies
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Fu, T; Jing, Y; Li, G; Li, J; Liu, Y; Lv, Z; Shao, C; Wang, Z; Zhao, Y1
Baek, JM; Bin, BH; Brito, S; Chae, S; Choi, MA; Heo, H; In, KR; Jang, D; Jo, H; Kang, MA; Kim, DO; Kim, JR; Kim, ST; Lee, JS; Lee, MG; Park, H1
Bouvet, M; Han, Q; Hayashi, K; Higuchi, T; Hoffman, RM; Igarashi, K; Kimura, H; Kuchipudi, S; Miwa, S; Oshiro, H; Singh, SR; Sugisawa, N; Tan, Y; Tsuchiya, H; Yamamoto, J; Yamamoto, N1
Chen, N; Cheng, L; Dai, L; Deng, H; Dong, Z; Fang, C; Fu, J; Ji, Y; Li, J; Liu, Y; Shi, G; Su, X; Wang, H; Wang, W; Yang, Y; Yu, Y; Zhang, H; Zhang, S1
Boghaert, ER; Cojocari, D; Jin, S; Leverson, JD; Phillips, DC; Popovic, R; Purkal, JJ; Solomon, LR; Talaty, NN; Xiao, Y1
Battafarano, RJ; Baylin, SB; Brahmer, JR; Brock, MV; Broderick, SR; Bush, EL; Cai, Y; Cattaneo, SM; Cui, Y; Day, CP; Easwaran, H; Forde, PM; Housseau, F; Huang, P; Hulbert, A; Jiao, X; Juergens, RA; Kim, K; Kim, YJ; Kong, X; Lee, B; Li, H; Li, S; Lu, Z; Margolick, JB; Mei, Y; Nelkin, BD; Pardoll, DM; Riemer, JB; Rodgers, K; Rudin, CM; Shen, L; Tao, Y; Topper, MJ; Vaz, M; Wang, KK; Wang, Y; Wrangle, J; Xia, L; Xie, W; Yang, SC; Yen, RC; Zahnow, CA; Zhang, B; Zhang, H; Zhang, W; Zou, J1
Huang, F; Jiang, C; Jin, N; Li, C; Li, X; Liu, Q; Qin, Y; Zhang, C; Zhang, Y; Zhao, Y; Zhou, C1
Arrate, M; Azab, M; Boyd, K; Fuller, L; Gorska, AE; Keer, H; Oganesian, A; Ramsey, HE; Savona, MR1
Diamond, DJ; Ebelt, ND; Johnson, BL; Manuel, ER; Zuniga, E1
Adams, FF; Alwie, Y; Gabdoulline, R; Ganser, A; Gupta, C; Heckl, D; Heuser, M; Humphries, RK; Imren, S; Jyotsana, N; Kattre, N; Kloos, A; Mintzas, K; Schambach, A; Scherr, M; Schottmann, R; Schwarzer, A; Thol, F; Winckler, L1
Carraway, H; Durkin, L; Grabowski, D; Gu, X; Hamilton, B; Hasipek, M; Hong, C; Hsi, ED; Jha, BK; Maciejewski, J; Patel, B; Radivoyevitch, T; Sakre, N; Saunthararajah, Y; Schuerger, C; Sobecks, R; Tohme, R; Tomlinson, B; Zidan, AM1
Bachmaier, G; Berg, JL; Berghold, A; Geissler, K; Hatzl, S; Hoefler, G; Klymiuk, I; Mayer, MC; Perfler, B; Pichler, M; Pregartner, G; Reinisch, A; Sill, H; Strobl, H; Tierling, S; Uhl, B; Wölfler, A; Wurm, S; Zebisch, A1
Bassermann, F; Dahl, S; Haas, T; Heidegger, S; Poeck, H; Wintges, A1
Fang, F; Nephew, KP; Ozes, A; Wang, W1
Chen, Y; Huang, Z; Li, R; Li, Z; Liang, X; Lin, T; Liu, S; Ma, J; Shi, W; Tan, X; Wang, W; Ye, Z; Yu, C; Zhang, B; Zhang, H; Zhang, L; Zhang, Q; Zhao, X1
Arend, RC; Buchsbaum, DJ; Forero, A; Katre, A; Londoño, A; Meza-Perez, S; Norian, LA; Peabody, JE; Randall, TD; Smith, HJ; Straughn, JM; Turner, TB1
Ming, F; Sun, Q1
Chen, M; Dong, L; Feng, K; Han, W; Jia, H; Li, X; Liu, L; Liu, Y; Mei, Q; Nie, J; Shi, L; Zhang, Y1
Chen, JK; Ding, HF; Dong, Z; Fan, G; Guo, C; Huang, S; Pei, L; Shi, H; Wei, Q; Xiao, X1
Cao, J; Chen, P; Chen, Y; He, SD; He, ZH; Liu, D; Ye, JR; Zeng, HH1
Bachman, KE; Baylin, SB; Bhargava, V; Chiappinelli, KB; Cowley, GS; Hung, CF; Li, H; Lim, M; Mathios, D; Murphy, LM; Shih, IM; Stone, ML; Strick, R; Strissel, PL; Topper, MJ; Travers, ME; Wang, TL; Wiehagen, KR; Zahnow, CA1
Bushell, MD; Godfrey, JD; Morton, JP; Sansom, OJ; Wilczynska, A1
Choi, DH; Choi, IA; Kim, HY; Lee, CS; Lee, J1
Bickerton, S; Fahmy, TM; Kong, P; Li, H; Li, Y; Moulton, VR; Sharabi, A; Tsokos, GC; Tsokos, MG1
Anastasiadou, E; Avigan, D; Cole, L; Ephraim, A; Ghiasuddin, H; Jain, S; Kufe, D; Leaf, RK; Liegel, J; McMasters, M; Molldrem, JJ; Nahas, MR; Orr, S; Pyzer, AR; Rahimian, M; Rosenblatt, J; Sergeeva, A; Slack, F; Stroopinsky, D; Washington, A; Weinstock, M1
Balog, A; Block, JA; Bukiej, AA; Glant, TT; Jolly, M; Kovács, L; Markovics, A; Mikecz, K; Ocskó, T; Rauch, TA; Ruthberg, AD; Tóth, DM; Vida, A1
Bachman, KE; Baylin, SB; Brown, SM; Casero, RA; Dunworth, M; Foley, JR; Holbert, CE; Stone, ML; Travers, M; Wiehagen, KR; Zahnow, CA1
Chen, G; Chen, H; Dong, Z; Liu, H; Liu, Y; Ren, S; Sun, L; Tang, L; Xia, M; Zhang, L; Zhu, J1
Deng, X; Hu, Z; Li, X; Liu, Z; Zhou, Y1
Barak, S; Darcq, E; Levine, A; Ron, D; Warnault, V1
Dong, Y; Huang, H; Li, Q; Ning, Y; Sun, Q; Xu, W; Zhang, W1
Mori, A; Niwa, T; Tatematsu, M; Toyoda, T; Tsukamoto, T; Ushijima, T1
Cai, X; Chen, K; Chen, Q; Huang, A; Li, S; Nie, D; Quan, H; Shan, X; Tang, N; Zhou, F; Zhou, Z1
Katiyar, SK; Prasad, R1
Richards, KL; Small, GW; Smallwood, TL; Suter, SE1
Bolyard, C; Chiocca, EA; Fernandez, S; Haseley, A; Kasai, K; Kaur, B; Lehman, A; Meisen, H; Mo, X; Okemoto, K; Wagner, B; Wehr, A1
Chen, P; Chen, Y; He, Z; Peng, H; Zeng, H; Zhang, H; Zhang, Y1
Jiang, Z; Kuo, PY; Leshchenko, VV; Parekh, S; Thirukonda, VK1
Barankiewicz, J; Bednarek, W; Boon, L; Gabrysiak, M; Golab, J; Hamblin, MR; Mroz, P; Muchowicz, A; Rygiel, T; Wachowska, M1
Chen, L; He, QM; Jiang, N; Jiang, W; Li, YQ; Liu, N; Ma, J; Sun, Y; Xu, YF1
Bendtzen, K; Coco, M; Di Marco, R; Di Rosa, M; Fagone, P; Magro, G; Malaguarnera, L; Mammana, S; Mangano, K; Meroni, PL; Nicoletti, F; Quattrocchi, C1
De Vita, S; Ebert, BL; Garcia, M; Gavillet, M; Gerbaulet, A; Levine, RL; Mullally, A; Roers, A; Schneider, RK; Williams, DA; Wood, J1
De Bruyne, E; De Raeve, H; De Smedt, E; Lemaire, M; Maes, K; McClue, S; Menu, E; Van Valckenborgh, E; Vanderkerken, K1
Dunn, J; Fan, Y; Hoffman, R; Jang, I; Jjingo, D; Jo, H; Jordan, IK; Kim, CW; Kim, D; Kim, S; Pan, C; Qiu, H; Son, DJ1
Baylin, SB; Beaty, R; Bunz, F; Cui, Y; Hausheer, F; Issa, JP; Zahnow, C1
Dawn, B; Elias, HK; Malik, AB; Rajasingh, J; Rajasingh, S; Simpson, AD; Sundivakkam, PK; Thangavel, J; Vogel, SM; Xuan, YT1
Campbell, RR; Dang, D; Ono, K; Schmidt, BL; Viet, CT; Ye, Y1
Cao, JL; Peng, YN; Tang, LH; Wang, Y; Yan, M; Yu, LN; Zhou, XL1
Han, J; Sui, N; Zhang, JJ1
Ahn, JS; Cho, JH; Choi, JY; Kim, CD; Kim, KH; Kim, YL; Lee, JH; Oh, EJ; Oh, SH; Park, SH; Ryu, HM1
Agrawal, R; Gomez-Pinilla, F; Tyagi, E; Ying, Z; Zhuang, Y1
Aggarwal, NR; Chau, E; D'Alessio, FR; Florez, MA; Garibaldi, BT; Gibbs, KW; King, LS; Mandke, P; Mock, JR; Sidhaye, VK; Singer, BD; Tripathi, A; Yegnasubramanian, S1
Azab, M; Choy, G; Fang, F; Lyons, J; Matei, D; Miller, DF; Munck, J; Nephew, KP; Pawelczak, KS; Pilrose, J; Tang, J; Taverna, P; Turchi, JJ; VanderVere-Carozza, P; Wagner, M; Wang, Y1
Claret, FX; Wang, S; Yang, H; Zhang, R1
Hu, Z; Lian, F; Wang, Y; Xue, S; Yang, W; Zheng, H1
Liang, Y; Perez-Soler, R; Qiu, X; Sellers, RS; Zou, Y1
André, MC; Bühring, HJ; Ebinger, M; Handgretinger, R; Hartwig, UF; Herr, W; Kübler, A; Lang, P; Mezger, M; Münz, C; Oevermann, L; Witte, KE; Woiterski, J1
Abdolhosseini, M; Benakanakere, M; Finoti, LS; Hosur, K; Kinane, DF1
Arango-Gonzalez, B; Biel, M; Carell, T; Ekström, PA; Farinelli, P; Michalakis, S; Paquet-Durand, F; Perera, A; Trifunovic, D; Wagner, M; Zrenner, E1
Anthony, S; Corre, A; Gong, M; Liu, J; Rehan, VK; Sakurai, R1
Biankin, AV; Caldon, CE; Chang, DK; Colvin, EK; Henshall, SM; Mawson, A; Musgrove, EA; Pajic, M; Pinese, M; Scarlett, CJ; Susanto, JM; Sutherland, RL1
Gu, TX; Guan, XY; Jiang, DQ; Li, XY; Qi, X; Sun, XJ; Tang, R; Zhang, GW1
Cao, J; Chen, HQ; Han, F; Huang, C; Jiang, X; Li, YH; Liu, JY; Liu, WB; Liu, Y; Zhao, H1
Baugh, J; Corrigan, N; Glezeva, N; Horgan, S; Ledwidge, M; McDonald, K; Neary, R; Tea, I; Watson, CJ1
Gorman, S; Hart, PH; McGonigle, TA; Ng, RL; Scott, NM1
Antonios, JP; Everson, RG; Garrett, MC; Kruse, CA; Li, G; Li, N; Liau, LM; Lisiero, DN; Prins, RM; Scharnweber, R; Soto, H; Yong, WH1
Dong, Y; Ji, T; Liang, J; Ma, Z; Xiao, Y; Yin, G1
Chen, Y; Du, Q; Huang, Y; She, F; Wu, W1
Basavarajappa, BS; Nagre, NN; Shivakumar, M; Subbanna, S1
Bracci, L; Buccione, C; Businaro, L; D'Urso, MT; De Ninno, A; Gerardino, A; Lucarini, V; Macchia, D; Macchia, I; Mattei, F; Mattia, G; Mozetic, P; Parolini, I; Peschiaroli, F; Puglisi, R; Rainer, A; Rossi, A; Schiavoni, G; Sestili, P; Spada, M; Trombetta, M; Zanetti, C; Ziccheddu, G1
Cao, M; Hu, Y; Wu, H; Xue, X; Zhao, S1
Huang, X; Kong, G; Li, J; Li, Y; Liu, X; Wang, L; Wang, X; Wu, Y; Xu, H; Zhang, X; Zhang, Z; Zhu, W1
Li, H; Luan, P; Peng, W; Wang, K; Xu, Y; Zhang, P; Zhuang, J1
Han, Y; Han, YC; Jia, X; Li, F; Li, X; Ren, Z; Song, N; Xu, JX; Zhou, Y1
Ali, MW; Alqinyah, M; Cacan, E; Gao, M; Greer, SF; Hooks, SB; Maganti, N; Weng, HR; Yadav, R1
Huang, P; Jarpe, MB; Jones, SS; Min, C; Moore, N; Quayle, SN; Shearstone, JR; van Duzer, JH; Yang, M1
Balestrieri, C; Bertoni, F; Leoni, C; Montagner, S; Monticelli, S; Polletti, S; Rinaldi, A1
Fonte, E; Ghia, P; Muzio, M; Ntoufa, S; Papakonstantinou, N; Ranghetti, P; Scarfò, L; Stamatopoulos, K; Tocchetti, M; Veliz Rodriguez, T; Vilia, MG1
Bailey, N; Boon, K; Brass, DM; Garantziotis, S; Hollingsworth, JW; Li, Z; Maruoka, S; Potts, EN; Schwartz, DA; Tomfohr, J; Whitehead, G1
Chang, H; Chen, G; Feng, Y; Huang, H; Lin, F; Sun, A; Wang, Y; Wu, D1
Bologna, M; D'Alessandro, AM; Dolo, V; Festuccia, C; Gravina, GL; Millimaggi, D; Muzi, P; Ricevuto, E; Vicentini, C1
Fujiki, K; Kano, F; Murata, M; Shiota, K1
Chang, JK; Chang, LH; Chen, CH; Fu, YC; Ho, ML; Hung, SH; Lee, HY; Lin, YS; Wang, GJ; Wu, SC1
Baumann, S; Drost, AC; Feil, G; Kanz, L; Möhle, R; Schäfer, J; Sievert, KD; Stenzl, A; Weng, S1
Ao, L; Cao, J; Cui, ZH; Liu, JY; Liu, WB; Xiang, YL; Yuan, XY; Zhou, YH; Zhou, ZY1
Biojone, C; Gomes, MV; Guimarães, FS; Joca, SR; Sales, AJ; Terceti, MS1
Cao, G; Li, Y; Mu, Y; Zeng, Q1
Guo, QL; Huang, CS; Liu, C; Wang, Y; Yan, JQ; Zhu, XY; Zou, WY1
Chang, YL; Hong, TM; Jou, YS; Lin, JC; Lin, TC; Wu, CT; Wu, JY; Wu, YY; Yang, PC1
Kawamichi, Y; Saito, K; Umezawa, A1
Cao, F; Fan, W; Liang, D; Pei, X; Qin, X; Sun, D; Wang, S; Wang, Y; Xie, X1
Chang, C; Huang, CK; Jiang, Q; Lai, KP; Lee, SO; Li, L; Liang, L; Lin, TH; Luo, J; Ma, Z; Niu, Y; Tian, J; Yamashita, S; Yeh, CR; Yeh, S1
Ray, D; Richardson, B; Sawalha, AH; Yung, R1
Gallacher, J; Kalogerou, M; Sampson, JR; Shen, MH; Yang, J1
Bollag, G; Bornman, WG; Davies, MA; Dayyani, F; Desai, J; Gallick, GE; Gopal, YN; Jiang, ZQ; Kopetz, S; Lemos, R; Mao, M; Mariadason, JM; Mills, GB; Powis, G; Tang, XM; Tian, F; Tsao, CC; Wistuba, II1
Batte, K; Cantemir-Stone, CZ; Dakhlallah, D; Hitchcock, CL; Marsh, CB; Mikhail, A; Nana-Sinkam, SP; Nuovo, G; Piper, MG; Wang, Y; Wright, VP; Yan, P1
Bartoli, A; Delfino, DV; Di Ianni, M; Fetriconi, I; Fettucciari, K; Marconi, P; Rosati, E; Rossi, R; Tabilio, A1
Bae, YC; Baik, SY; Jung, JS; Kang, SK; Kim, HK; Lee, DH1
Adams, RJ; Atweh, GF; DeSimone, J; Fabry, ME; Fathallah, H; Nagel, RL; Saunthararajah, Y; Weinberg, RS1
Ray, D; Richardson, B; Yung, R1
Alleman, WG; Aprelikova, ON; Chandramouli, GV; Linehan, WM; Mendoza, A; Rodgers, C; Rogers, C; Sopko, NA; Tabios, RL; Torres-Cabala, C; Vasselli, JR1
Momparler, RL1
Chan, J; Fisk, NM; Gavina, M; Kennea, N; Mehmet, H; Morgan, JE; O'Donoghue, K; Stewart, H; Torrente, Y; Watt, DJ1
Haider, HKh1
Alexeeva, IV; Dyachenko, NS; Nosach, LN; Palchikovskaya, LI; Povnitsa, OY; Slita, AV; Sukhinin, VP; Zarubalev, VV; Zhovnovataya, VL1
Day, ML; Gschwend, JE; Kuefer, R; McCabe, MT; Wojno, KJ; Zorn, CS1
Doskocil, J; Rada, B1
DeSimone, J; Heller, P1
Benfield, JR; Hammond, WG1
Hoyt, PR; Popp, D; Saavedra, HI; Stambrook, PJ; Wang, TH; Yang, WK1
Erf, GF; Smyth, JR; Sreekumar, GP1
Baylin, SB; Belinsky, SA; Herman, JG; Middleton, SK; Nikula, KJ; Palmisano, WA; Swafford, DS; Tesfaigzi, J1
Ambady, S; Ponce de Leon, FA; Smyth, JR; Sreekumar, GP1
Hatta, T; Matsumoto, A; Moriyama, K; Otani, H1
Benedict, WF; Khwaja, TA1
Matsuda, M1
Glynn, JP; Goldberg, AI; Goldin, A; Kende, M; Mantel, N1

Reviews

7 review(s) available for azacitidine and Disease Models, Animal

ArticleYear
[Cell fusion as a key mechanism for cell-based therapy towards Duchenne muscular dystrophy].
    Seikagaku. The Journal of Japanese Biochemical Society, 2012, Volume: 84, Issue:2

    Topics: Animals; Azacitidine; Cell Differentiation; Cell Fusion; Cell Transplantation; Cell- and Tissue-Based Therapy; Disease Models, Animal; Dystrophin; Endometrium; Female; Humans; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Placenta; Pregnancy; Regenerative Medicine

2012
Hemoglobinopathies.
    Hematology. American Society of Hematology. Education Program, 2003

    Topics: Animals; Azacitidine; Butyrates; Cerebral Hemorrhage; Decitabine; Disease Models, Animal; DNA Methylation; Globins; Hemoglobinopathies; Humans; Hydroxyurea; Mice; Stroke

2003
Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine).
    Seminars in oncology, 2005, Volume: 32, Issue:5

    Topics: Alleles; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cellular Senescence; Clinical Trials as Topic; Decitabine; Disease Models, Animal; DNA; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Gene Silencing; Genes, Tumor Suppressor; Humans; Models, Biological; Models, Chemical; Neoplasms; Phenotype; Phosphorylation; Prodrugs; S Phase; Time Factors

2005
Bone marrow cells for cardiac regeneration and repair: current status and issues.
    Expert review of cardiovascular therapy, 2006, Volume: 4, Issue:4

    Topics: Animals; Antigens, CD34; Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Movement; Cells, Cultured; Coronary Artery Bypass; Disease Models, Animal; Humans; Myocytes, Cardiac; Phenotype; Regeneration; Ventricular Dysfunction, Left

2006
Azapyramidine nucleosides.
    Pharmacology & therapeutics, 1980, Volume: 9, Issue:2

    Topics: Animals; Antiviral Agents; Aza Compounds; Azacitidine; Azauridine; Chemical Phenomena; Chemistry; Disease Models, Animal; Embryo, Mammalian; Humans; Immunosuppressive Agents; Kinetics; Pyrimidine Nucleosides; Structure-Activity Relationship; Virus Replication

1980
5-Azacytidine and fetal hemoglobin.
    American journal of hematology, 1984, Volume: 17, Issue:4

    Topics: Adult; Anemia, Sickle Cell; Animals; Azacitidine; Carcinogens; Disease Models, Animal; DNA; Fetal Hemoglobin; Gene Expression Regulation; Humans; Male; Methylation; Middle Aged; Papio; Thalassemia

1984
Hamster bronchial carcinogenesis induced by carcinogen-containing sustained release implants placed endobronchially: a clinically relevant model.
    Journal of cellular biochemistry. Supplement, 1993, Volume: 17F

    Topics: Animals; Azacitidine; Bronchial Neoplasms; Carcinogens; Cricetinae; Disease Models, Animal; Doxorubicin; Drug Implants; Humans; Mesocricetus; Mycobacterium bovis; Neoplasm Metastasis

1993

Trials

1 trial(s) available for azacitidine and Disease Models, Animal

ArticleYear
Increased IFNγ
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Oct-15, Volume: 23, Issue:20

    Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cytotoxicity, Immunologic; Decitabine; Disease Models, Animal; Disease Progression; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Humans; Interferon-gamma; Lymphocyte Activation; Male; Mice; Neoplasms; Survival Analysis; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Th1 Cells; Treatment Outcome; Xenograft Model Antitumor Assays

2017

Other Studies

111 other study(ies) available for azacitidine and Disease Models, Animal

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries

2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
DNA methyltransferases inhibitor azacitidine improves the skeletal phenotype of mild osteogenesis imperfecta by reversing the impaired osteogenesis and excessive osteoclastogenesis.
    Bone, 2023, Volume: 170

    Topics: Animals; Azacitidine; Collagen; Disease Models, Animal; DNA; Enzyme Inhibitors; Methyltransferases; Mice; Osteogenesis; Osteogenesis Imperfecta; Phenotype

2023
Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy.
    Scientific reports, 2019, 10-21, Volume: 9, Issue:1

    Topics: Animals; Autophagy; Azacitidine; Cation Transport Proteins; Cell Death; Cell Line; Dermis; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Ethylenediamines; Fibrosarcoma; Humans; Mice, Knockout; Microtubule-Associated Proteins; Zinc

2019
The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:2

    Topics: Adolescent; Animals; Antineoplastic Agents; Azacitidine; Bone Neoplasms; Carbon-Sulfur Lyases; Combined Modality Therapy; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Heterografts; Humans; Male; Mice; Mice, Nude; Osteosarcoma; Tumor Burden; Xenograft Model Antitumor Assays

2020
Temporal DNA methylation pattern and targeted therapy in colitis-associated cancer.
    Carcinogenesis, 2020, 04-22, Volume: 41, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Azoxymethane; bcl-Associated Death Protein; Carcinogenesis; Cell Line, Tumor; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Decitabine; Disease Models, Animal; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Male; Mice; Molecular Targeted Therapy; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Up-Regulation

2020
5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 07-01, Volume: 26, Issue:13

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; Humans; Leukemia, Myeloid, Acute; Mice; Proto-Oncogene Proteins c-bcl-2; Sulfonamides

2020
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
    Nature, 2020, Volume: 579, Issue:7798

    Topics: Animals; Azacitidine; Benzamides; Cell Differentiation; Cell Movement; Chemotherapy, Adjuvant; Disease Models, Animal; Down-Regulation; Epigenesis, Genetic; Genetic Therapy; Mice; Myeloid-Derived Suppressor Cells; Neoplasm Metastasis; Neoplasms; Pyridines; Receptors, CCR2; Receptors, Interleukin-8B; Tumor Microenvironment

2020
Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury.
    PLoS pathogens, 2020, Volume: 16, Issue:3

    Topics: Acute Lung Injury; Amitriptyline; Animals; Azacitidine; Calcitriol; Disease Models, Animal; Drug Repositioning; Female; Flavin-Adenine Dinucleotide; Humans; Influenza A Virus, H5N1 Subtype; Influenza, Human; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL

2020
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
    Targeted oncology, 2020, Volume: 15, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Disease Models, Animal; Female; Haplorhini; Humans; Infusions, Parenteral; Mice; Treatment Outcome; Uridine

2020
5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; DNA Transposable Elements; Humans; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms

2020
Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia.
    Leukemia, 2020, Volume: 34, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clonal Evolution; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Female; GTP Phosphohydrolases; Humans; Leukemia, Myelomonocytic, Chronic; Membrane Proteins; Mice; Mutation; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Receptor, Notch1; RNA, Small Interfering; Xenograft Model Antitumor Assays

2020
Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network.
    Leukemia, 2021, Volume: 35, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Metabolic Networks and Pathways; Mice; Pyrimidines; Uridine Kinase

2021
Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia.
    Clinical epigenetics, 2021, 01-06, Volume: 13, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Disease Models, Animal; DNA Methylation; Gene Expression Regulation; Genome-Wide Association Study; Humans; Leukemia, Myelomonocytic, Chronic; Mice; RNA, Messenger

2021
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
    European journal of immunology, 2021, Volume: 51, Issue:6

    Topics: Animals; Azacitidine; Chemoradiotherapy; Disease Models, Animal; Drug Synergism; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Receptors, Cell Surface; Signal Transduction; Treatment Outcome

2021
Targeting Ovarian Cancer Stem Cells by Dual Inhibition of HOTAIR and DNA Methylation.
    Molecular cancer therapeutics, 2021, Volume: 20, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Humans; Mice; Neoplastic Stem Cells; Ovarian Neoplasms; Peptide Nucleic Acids; RNA, Long Noncoding; Xenograft Model Antitumor Assays

2021
DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury.
    Kidney international, 2017, Volume: 92, Issue:1

    Topics: Albuminuria; Animals; Azacitidine; Binding Sites; Cell Line; Cell Movement; Cell Proliferation; Cytoprotection; Decitabine; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Male; Mice, Inbred C57BL; Podocytes; Promoter Regions, Genetic; RNA Interference; Sp1 Transcription Factor; Time Factors; Transcription Factor RelA; Transfection

2017
Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
    Oncotarget, 2017, Jul-04, Volume: 8, Issue:27

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Benzamides; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Drug Synergism; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class II; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Mice; Ovarian Neoplasms; Panobinostat; Pyridines; RNA, Messenger; Transcription, Genetic; Tumor Burden; Xenograft Model Antitumor Assays

2017
Epigenetically silenced PTPRO functions as a prognostic marker and tumor suppressor in human lung squamous cell carcinoma.
    Molecular medicine reports, 2017, Volume: 16, Issue:1

    Topics: Adult; Aged; Animals; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; CpG Islands; Decitabine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Exons; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Heterografts; Humans; Lung Neoplasms; Male; Mice; Middle Aged; Prognosis; Receptor-Like Protein Tyrosine Phosphatases, Class 3

2017
DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8.
    Kidney international, 2017, Volume: 92, Issue:5

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Azacitidine; Cell Line; Cisplatin; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Epigenesis, Genetic; Gene Knockdown Techniques; Genome; Humans; Interferon Regulatory Factors; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Rats; Sequence Analysis, DNA

2017
5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16
    International journal of chronic obstructive pulmonary disease, 2017, Volume: 12

    Topics: Animals; Azacitidine; Cells, Cultured; Cigarette Smoking; Cyclin-Dependent Kinase Inhibitor p16; Cytoprotection; Decitabine; Disease Models, Animal; Down-Regulation; Endothelial Progenitor Cells; Lung; Male; Mice, Inbred C57BL; Pulmonary Emphysema; Signal Transduction; Smoke

2017
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 12-19, Volume: 114, Issue:51

    Topics: Animals; Antineoplastic Agents, Immunological; Azacitidine; Cell Line, Tumor; Disease Models, Animal; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Immunomodulation; Interferon Type I; Mice; Ovarian Neoplasms; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2017
MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
    Cell death & disease, 2018, 05-29, Volume: 9, Issue:6

    Topics: Animals; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; CpG Islands; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Genetic Loci; Humans; Mice; MicroRNAs; Mutation; Neoplasm Invasiveness; Pancreatic Neoplasms; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53

2018
Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery.
    International journal of molecular sciences, 2018, Jul-11, Volume: 19, Issue:7

    Topics: Animals; Axons; Azacitidine; Brain-Derived Neurotrophic Factor; Decitabine; Disease Models, Animal; DNA Methylation; Exercise; Gene Expression Regulation; Humans; Male; Neuronal Plasticity; Rats; Stroke; Stroke Rehabilitation; Task Performance and Analysis

2018
Precision DNA demethylation ameliorates disease in lupus-prone mice.
    JCI insight, 2018, 08-23, Volume: 3, Issue:16

    Topics: Animals; Azacitidine; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Female; Humans; Immunoconjugates; Lupus Erythematosus, Systemic; Mice; Mice, Transgenic; Nanoconjugates; Treatment Outcome

2018
Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine.
    British journal of haematology, 2019, Volume: 185, Issue:4

    Topics: Animals; Antineoplastic Agents, Immunological; Azacitidine; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; DNA Methylation; Down-Regulation; Humans; Immunity, Cellular; Leukemia, Myeloid, Acute; Mice, Inbred C57BL; Neoplasm Transplantation; Programmed Cell Death 1 Receptor; Retroviridae; Tumor Microenvironment; Virus Activation

2019
Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:8

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Azacitidine; B-Lymphocytes; Chromatin Immunoprecipitation; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Flow Cytometry; Gene Silencing; Mice

2019
DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.
    Cancer research, 2019, 07-01, Volume: 79, Issue:13

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cystadenocarcinoma, Serous; Disease Models, Animal; Eflornithine; Female; Immunity, Innate; Macrophages; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; Polyamines; Tumor Cells, Cultured; Tumor Microenvironment

2019
Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease.
    Kidney international, 2019, Volume: 96, Issue:2

    Topics: Adolescent; Adoptive Transfer; Adult; Aged; Animals; Azacitidine; Cytosine; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Epigenesis, Genetic; Female; Gene Knockdown Techniques; Humans; Leukocytes, Mononuclear; Male; Mice; Middle Aged; Primary Cell Culture; Promoter Regions, Genetic; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Young Adult

2019
Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model.
    Scientific reports, 2019, 05-29, Volume: 9, Issue:1

    Topics: Animals; Azacitidine; Cochlea; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; Ear, Inner; Enzyme Inhibitors; Furosemide; Hair Cells, Auditory, Inner; Hearing Loss; Humans; Kanamycin; Mice; Regeneration

2019
Chromatin remodeling--a novel strategy to control excessive alcohol drinking.
    Translational psychiatry, 2013, Feb-19, Volume: 3

    Topics: Acetylation; Alcoholism; Animals; Azacitidine; Behavior, Animal; Chromatin Assembly and Disassembly; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Histone Deacetylase Inhibitors; Histones; Humans; Mice; Rats

2013
5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching.
    Archives of toxicology, 2013, Volume: 87, Issue:5

    Topics: Airway Remodeling; Animals; Asthma; Azacitidine; Becaplermin; Biomarkers; Cell Cycle; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Techniques; Cytoskeleton; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Enzyme Inhibitors; Muscle Contraction; Muscle, Smooth; Phenotype; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Transcription, Genetic

2013
Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:4

    Topics: Adenocarcinoma; Animals; Azacitidine; Carcinogens; Decitabine; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Stomach Neoplasms

2013
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
    Oncogene, 2014, May-29, Volume: 33, Issue:22

    Topics: Acetylation; Animals; Azacitidine; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Histones; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Tumor Burden; Viral Core Proteins; Wnt Proteins; Xenograft Model Antitumor Assays

2014
Prostaglandin E2 Promotes UV radiation-induced immune suppression through DNA hypermethylation.
    Neoplasia (New York, N.Y.), 2013, Volume: 15, Issue:7

    Topics: Animals; Azacitidine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dermatitis, Contact; Dinoprostone; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Activation; Female; Gene Expression Regulation; Immune Tolerance; Male; Mice; Mice, Knockout; Radiation Tolerance; Receptors, Prostaglandin E, EP2 Subtype; Sp1 Transcription Factor; Sp3 Transcription Factor; Ultraviolet Rays

2013
Expression of asparagine synthetase predicts in vitro response to L-asparaginase in canine lymphoid cell lines.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:6

    Topics: Animals; Asparaginase; Aspartate-Ammonia Ligase; Azacitidine; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Dogs; Drug Resistance, Neoplasm; Gene Expression; Humans; Lymphocytes; Lymphoma; Promoter Regions, Genetic; RNA, Messenger

2014
DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Nov-01, Volume: 19, Issue:21

    Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Survival; CpG Islands; Disease Models, Animal; DNA Methylation; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Viral; Genetic Therapy; Genetic Vectors; Glioma; Herpesvirus 1, Human; Humans; Mice; Nestin; Oncolytic Virotherapy; Oncolytic Viruses; Promoter Regions, Genetic; Viral Proteins; Virus Replication; Xenograft Model Antitumor Assays

2013
Protective effect of demethylation treatment on cigarette smoke extract-induced mouse emphysema model.
    Journal of pharmacological sciences, 2013, Volume: 123, Issue:2

    Topics: Animals; Apoptosis; Azacitidine; Decitabine; Disease Models, Animal; DNA-Binding Proteins; Electron Transport Complex IV; Emphysema; Lung; Male; Methylation; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Proteins; RNA, Messenger; Smoking; Transcription Factors

2013
Integrative genomic analysis of temozolomide resistance in diffuse large B-cell lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jan-15, Volume: 20, Issue:2

    Topics: Animals; Antineoplastic Agents, Alkylating; Azacitidine; Cell Line, Tumor; Dacarbazine; Decitabine; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genomics; Humans; Lymphoma, Large B-Cell, Diffuse; Promoter Regions, Genetic; Temozolomide; Transcription Factors; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2014
5-Aza-2'-deoxycytidine potentiates antitumour immune response induced by photodynamic therapy.
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:7

    Topics: Animals; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Lewis Lung; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Decitabine; Disease Models, Animal; Female; Flow Cytometry; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Photochemotherapy; Reverse Transcriptase Polymerase Chain Reaction

2014
5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA Methylation; DNA Repair; Epigenesis, Genetic; Female; Gene Silencing; Humans; Mice; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Burden; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays

2014
Hypomethylating agent 5-aza-2'-deoxycytidine (DAC) ameliorates multiple sclerosis in mouse models.
    Journal of cellular physiology, 2014, Volume: 229, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Azacitidine; Cytokines; Decitabine; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Mice; Multiple Sclerosis; T-Lymphocytes, Regulatory

2014
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Animals; Azacitidine; Blotting, Western; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dasatinib; Decitabine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Drug Therapy, Combination; Enzyme Inhibitors; Esophagus; Gastric Mucosa; Humans; Mast Cells; Mastocytosis, Systemic; Mice, Knockout; Mice, Transgenic; Mutation, Missense; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA Interference; Skin; Stomach; Thiazoles

2014
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma.
    Oncotarget, 2014, May-30, Volume: 5, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Azacitidine; Blotting, Western; Decitabine; Disease Models, Animal; DNA Damage; DNA Repair; Flow Cytometry; Fluorescent Antibody Technique; Homologous Recombination; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Multiple Myeloma; Real-Time Polymerase Chain Reaction

2014
Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:7

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Azacitidine; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Endothelial Cells; Epigenesis, Genetic; Gene Expression Regulation; Homeodomain Proteins; Human Umbilical Vein Endothelial Cells; Humans; Kruppel-Like Transcription Factors; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Plaque, Atherosclerotic; Promoter Regions, Genetic; Regional Blood Flow; RNA, Messenger; Stress, Mechanical; Transcription Factors

2014
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.
    Cancer research, 2014, Jul-15, Volume: 74, Issue:14

    Topics: Animals; Azacitidine; Cell Line, Tumor; CpG Islands; Disease Models, Animal; DNA Methylation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Order; Genes, Reporter; Green Fluorescent Proteins; Heterografts; Histone Deacetylase Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Recombinant Fusion Proteins; Transcriptional Activation

2014
Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury.
    The American journal of pathology, 2014, Volume: 184, Issue:8

    Topics: Acetylation; Acute Lung Injury; Animals; Azacitidine; Blotting, Western; Capillary Permeability; Cell Proliferation; Cell Survival; Chromatin Immunoprecipitation; Decitabine; Disease Models, Animal; Drug Therapy, Combination; Endothelial Cells; Endotoxemia; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Hydroxamic Acids; In Situ Nick-End Labeling; Inflammation; Lung; Male; Methylation; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction

2014
Demethylating drugs as novel analgesics for cancer pain.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Sep-15, Volume: 20, Issue:18

    Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Heterografts; Humans; Immunohistochemistry; In Situ Hybridization; Mice; Mouth Neoplasms; Neurons; Pain; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; Transduction, Genetic; Trigeminal Ganglion

2014
Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain.
    Molecular pain, 2014, Aug-13, Volume: 10

    Topics: Animals; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Methylation; Mice; Morphine; Neuralgia; Neuroblastoma; Pain Measurement; Pain Threshold; Promoter Regions, Genetic; Receptors, Opioid, mu; Sensory Receptor Cells; Spinal Cord

2014
Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Azacitidine; CA1 Region, Hippocampal; Cerebral Cortex; Conditioning, Psychological; Decitabine; Disease Models, Animal; DNA Modification Methylases; Enzyme Inhibitors; Male; Memory; Morphine; Morphine Dependence; Narcotics; Okadaic Acid; Rats, Sprague-Dawley; Reward; Spatial Behavior

2014
Effect of DNA demethylation in experimental encapsulating peritoneal sclerosis.
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2014, Volume: 18, Issue:6

    Topics: Animals; Azacitidine; Chlorhexidine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Ethanol; Gene Expression Regulation; Male; Peritoneal Dialysis; Peritoneal Fibrosis; ras GTPase-Activating Proteins; Rats; Rats, Sprague-Dawley

2014
Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet.
    Neurobiology of disease, 2015, Volume: 73

    Topics: Animals; Anxiety; Azacitidine; Brain; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Decitabine; Diet, Fat-Restricted; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, Omega-3; Female; Male; Maze Learning; Methylation; Mice; Neuroblastoma; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Transcription Factors

2015
Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.
    American journal of respiratory cell and molecular biology, 2015, Volume: 52, Issue:5

    Topics: Acute Lung Injury; Adoptive Transfer; Animals; Azacitidine; Cells, Cultured; Chemotaxis, Leukocyte; Decitabine; Disease Models, Animal; DNA Modification Methylases; Enzyme Inhibitors; Forkhead Transcription Factors; Homeodomain Proteins; Influenza A Virus, H1N1 Subtype; Lipopolysaccharides; Lung; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Pneumonia; T-Lymphocytes, Regulatory; Time Factors

2015
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Dec-15, Volume: 20, Issue:24

    Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cisplatin; Disease Models, Animal; DNA Adducts; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Ovarian Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

2014
Involvement of microRNA-24 and DNA methylation in resistance of nasopharyngeal carcinoma to ionizing radiation.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:12

    Topics: Animals; Azacitidine; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Decitabine; Disease Models, Animal; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Male; Mice; MicroRNAs; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Radiation Tolerance; Radiation, Ionizing; Tumor Burden; Xenograft Model Antitumor Assays

2014
Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.
    Molecular medicine reports, 2015, Volume: 11, Issue:1

    Topics: Actinin; Animals; Antigens, Surface; Azacitidine; Cell Culture Techniques; Cell Differentiation; Disease Models, Animal; Gene Expression Regulation; Immunophenotyping; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Myocytes, Cardiac; Nerve Tissue Proteins; Nuclear Proteins; Rats; RNA, Messenger; Troponin C

2015
Aerosol azacytidine inhibits orthotopic lung cancers in mice through Its DNA demethylation and gene reactivation effects.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Administration, Inhalation; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Female; Lung Neoplasms; Male; Mice; Promoter Regions, Genetic; Transcriptional Activation; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2014
Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice.
    Blood, 2014, Dec-18, Volume: 124, Issue:26

    Topics: Animals; Antineoplastic Agents; Azacitidine; Child; Cytokines; Cytotoxicity, Immunologic; Disease Models, Animal; DNA Methylation; Genotype; Graft vs Leukemia Effect; Hematopoietic Stem Cell Transplantation; Humans; Interleukin-2; Killer Cells, Natural; Mice; Mice, Inbred NOD; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Receptors, KIR; Transplantation, Heterologous

2014
TLR2 promoter hypermethylation creates innate immune dysbiosis.
    Journal of dental research, 2015, Volume: 94, Issue:1

    Topics: Animals; Azacitidine; Bacteroidaceae Infections; Cell Culture Techniques; Chronic Periodontitis; CpG Islands; Decitabine; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; Dysbiosis; Epigenesis, Genetic; Epithelial Cells; Genetic Predisposition to Disease; Gingiva; Host-Pathogen Interactions; Humans; Immunity, Innate; Inflammation Mediators; Interleukin-1beta; Mice; Mice, Inbred BALB C; Porphyromonas gingivalis; Toll-Like Receptor 2

2015
DNA methylation and differential gene regulation in photoreceptor cell death.
    Cell death & disease, 2014, Dec-04, Volume: 5

    Topics: Animals; Apoptosis Regulatory Proteins; Azacitidine; Cell Death; Cells, Cultured; Chromatin; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Eye Proteins; Humans; In Situ Nick-End Labeling; Mice; Mutation; Nerve Tissue Proteins; Photoreceptor Cells, Vertebrate; Rats; Retinitis Pigmentosa; Tissue Culture Techniques

2014
Perinatal nicotine exposure suppresses PPARγ epigenetically in lung alveolar interstitial fibroblasts.
    Molecular genetics and metabolism, 2015, Volume: 114, Issue:4

    Topics: Animals; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Fibroblasts; Fibronectins; Humans; Lung; Methyl-CpG-Binding Protein 2; Molecular Sequence Data; Nicotine; PPAR gamma; Pregnancy; Promoter Regions, Genetic; Pulmonary Alveoli; Rats; RNA, Messenger; Smoking; Up-Regulation

2015
The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.
    International journal of oncology, 2015, Volume: 46, Issue:5

    Topics: Animals; Antineoplastic Agents; Azacitidine; Blotting, Western; Cell Death; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Vorinostat

2015
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial ischemia.
    Cardiovascular therapeutics, 2015, Volume: 33, Issue:4

    Topics: Animals; Azacitidine; Calcium Channels, L-Type; Cell Differentiation; Cells, Cultured; Coronary Circulation; Disease Models, Animal; Fibroblast Growth Factor 2; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Neovascularization, Physiologic; Paracrine Communication; Phenotype; Proto-Oncogene Proteins c-kit; Regeneration; Swine; Swine, Miniature; Time Factors; Vascular Endothelial Growth Factor A; Ventricular Function, Left; von Willebrand Factor

2015
TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer.
    Oncotarget, 2015, Aug-28, Volume: 6, Issue:25

    Topics: Aged; Animals; Apoptosis; Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Male; Membrane Proteins; Middle Aged; Multivariate Analysis; Prognosis; Rats

2015
Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis.
    Journal of cardiovascular pharmacology and therapeutics, 2016, Volume: 21, Issue:1

    Topics: Actins; Animals; Azacitidine; Cardiomegaly; Carrier Proteins; Cells, Cultured; Collagen Type I; Collagen Type III; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Hypertension; Male; Myocytes, Cardiac; Rats, Inbred SHR; Rats, Inbred WKY; Transforming Growth Factor beta1; Ventricular Remodeling

2016
Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2015, Volume: 64, Issue:11

    Topics: Administration, Intranasal; Adoptive Transfer; Animals; Azacitidine; Bone Marrow Cells; Bronchoalveolar Lavage Fluid; Cell Count; Decitabine; Dendritic Cells; Disease Models, Animal; DNA Modification Methylases; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Immunoglobulin E; Immunoglobulin G; Inflammation; Lipopolysaccharides; Lymph Nodes; Mice, Inbred C57BL; Organic Chemicals; Ovalbumin; Radiation Chimera; Respiratory Hypersensitivity; Skin

2015
Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma.
    Neuro-oncology, 2016, Volume: 18, Issue:3

    Topics: Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Decitabine; Disease Models, Animal; Glioblastoma; Humans; Immunotherapy, Adoptive; Mice; T-Lymphocytes

2016
[5-aza-2'-deoxycytidine suppresses the growth of human lung adenocarcinoma cells in nude mouse xenograft models and its effect on methylation status and expression of TFPI-2 gene].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2015, Volume: 37, Issue:7

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Proliferation; Decitabine; Disease Models, Animal; DNA Methylation; Gene Expression Regulation, Neoplastic; Glycoproteins; Heterografts; Humans; Lung Neoplasms; Mice; Mice, Nude; Random Allocation; RNA, Messenger

2015
Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins.
    Molecular medicine reports, 2016, Volume: 14, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; Disease Models, Animal; DNA Methylation; Female; Gallbladder Neoplasms; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Mice; Middle Aged; Promoter Regions, Genetic; Repressor Proteins

2016
A single day of 5-azacytidine exposure during development induces neurodegeneration in neonatal mice and neurobehavioral deficits in adult mice.
    Physiology & behavior, 2016, 12-01, Volume: 167

    Topics: Animals; Animals, Newborn; Azacitidine; Brain; Brain Diseases; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Phosphopyruvate Hydratase; Receptor, Cannabinoid, CB1; Signal Transduction; Social Behavior

2016
Combining Type I Interferons and 5-Aza-2'-Deoxycitidine to Improve Anti-Tumor Response against Melanoma.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:1

    Topics: Analysis of Variance; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Interferon Type I; Melanoma; Mice; Mice, Inbred C57BL; Skin Neoplasms; Statistics, Nonparametric

2017
5-aza-2'-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia.
    Pediatrics and neonatology, 2017, Volume: 58, Issue:2

    Topics: Animals; Animals, Newborn; Azacitidine; Bronchopulmonary Dysplasia; Cell Proliferation; Decitabine; Disease Models, Animal; Enzyme Inhibitors; Fibroblasts; Hyperoxia; Lung; Rats; Rats, Sprague-Dawley

2017
Decitabine and 5-azacitidine both alleviate LPS induced ARDS through anti-inflammatory/antioxidant activity and protection of glycocalyx and inhibition of MAPK pathways in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Azacitidine; Decitabine; Disease Models, Animal; DNA Methylation; Glycocalyx; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Organ Size; Promoter Regions, Genetic; Respiratory Distress Syndrome; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins

2016
The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling.
    Arteriosclerosis, thrombosis, and vascular biology, 2017, Volume: 37, Issue:1

    Topics: 5-Methylcytosine; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Azacitidine; Cell Dedifferentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Decitabine; Diet, High-Fat; Dioxygenases; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Genetic Predisposition to Disease; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Proto-Oncogene Proteins; Rats; Signal Transduction; Time Factors; Trans-Activators; Vascular Remodeling

2017
Changes in the methylation status of the Oct3/4, Nanog, and Sox2 promoters in stem cells during regeneration of rat tracheal epithelium after injury.
    Oncotarget, 2017, Jan-10, Volume: 8, Issue:2

    Topics: Animals; Azacitidine; Disease Models, Animal; DNA Methylation; Gene Expression; Immunohistochemistry; Nanog Homeobox Protein; Octamer Transcription Factor-3; Promoter Regions, Genetic; Rats; Regeneration; Respiratory Mucosa; SOXB1 Transcription Factors; Stem Cells; Trachea; Wound Healing

2017
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity.
    Molecular pharmacology, 2017, Volume: 91, Issue:3

    Topics: Acetylation; Animals; Azacitidine; Cell Line; Chemokine CXCL2; Disease Models, Animal; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inflammation; Lipopolysaccharides; Lysophospholipids; Methyltransferases; Mice, Inbred C57BL; Microglia; Promoter Regions, Genetic; Receptors, G-Protein-Coupled; RGS Proteins; RNA, Messenger; Signal Transduction; Sphingosine; Transcription, Genetic; Tumor Necrosis Factor-alpha

2017
Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Animals; Antineoplastic Agents; Azacitidine; Biomarkers; Bone Marrow Cells; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Synergism; Female; GATA2 Transcription Factor; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Xenograft Model Antitumor Assays

2017
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 02-21, Volume: 114, Issue:8

    Topics: Animals; Azacitidine; Cell Degranulation; Cell Proliferation; Cells, Cultured; Decitabine; Dermatitis, Contact; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Immunoglobulin E; Interleukin-3; Mast Cells; Mastocytosis, Systemic; Mice; Mice, Knockout; Mutation; Oxazolone; Passive Cutaneous Anaphylaxis; ras GTPase-Activating Proteins; RNA Interference; RNA, Small Interfering

2017
The inhibitory receptor toll interleukin-1R 8 (TIR8/IL-1R8/SIGIRR) is downregulated in chronic lymphocytic leukemia.
    Leukemia & lymphoma, 2017, Volume: 58, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Disease Models, Animal; DNA Methylation; Humans; Inflammation; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Receptors, Interleukin-1

2017
In utero supplementation with methyl donors enhances allergic airway disease in mice.
    The Journal of clinical investigation, 2008, Volume: 118, Issue:10

    Topics: Animals; Asthma; Azacitidine; Cytokines; Dietary Supplements; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation; Lymphocytes; Male; Mice; Mice, Inbred C57BL; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Reproducibility of Results; Spleen

2008
Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma.
    European journal of haematology, 2009, Volume: 82, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Azacitidine; Base Sequence; Cell Line, Tumor; Disease Models, Animal; DNA Methylation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Proteins; Oxides; RNA, Messenger; Transcription, Genetic; Xenograft Model Antitumor Assays

2009
Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models.
    Endocrine-related cancer, 2009, Volume: 16, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Proliferation; Cisplatin; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Docetaxel; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Taxoids; Xenograft Model Antitumor Assays

2009
Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes.
    BMC biology, 2009, Jul-10, Volume: 7

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Azacitidine; Cell Proliferation; Chromatin Immunoprecipitation; Diabetes Mellitus; Dietary Fats; Disease Models, Animal; DNA Methylation; Enzyme Inhibitors; Gene Expression; Intra-Abdominal Fat; Male; Mice; Molecular Sequence Data; NIH 3T3 Cells; Obesity; PPAR gamma; Promoter Regions, Genetic; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Subcutaneous Fat, Abdominal

2009
Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats.
    Arthritis and rheumatism, 2009, Volume: 60, Issue:10

    Topics: Adult; Animals; Azacitidine; Cartilage, Articular; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrocytes; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Female; Glycosaminoglycans; Humans; Injections, Intra-Articular; Male; Middle Aged; Osteoarthritis; Papain; Parathyroid Hormone; Rats; Rats, Sprague-Dawley

2009
In vitro myogenic differentiation of human bone marrow-derived mesenchymal stem cells as a potential treatment for urethral sphincter muscle repair.
    Annals of the New York Academy of Sciences, 2009, Volume: 1176

    Topics: Animals; Azacitidine; Cell Differentiation; Disease Models, Animal; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Muscle Development; Rats; Rats, Nude; Urethral Diseases; Urinary Incontinence

2009
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
    Toxicology and applied pharmacology, 2011, Feb-15, Volume: 251, Issue:1

    Topics: Animals; Azacitidine; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Decitabine; Diethylnitrosamine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Enzyme Inhibitors; Female; Gene Silencing; Immunoglobulins; Lung Neoplasms; Male; Methylcholanthrene; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-3; Up-Regulation

2011
Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.
    British journal of pharmacology, 2011, Volume: 164, Issue:6

    Topics: Animals; Antidepressive Agents; Azacitidine; Behavior, Animal; Brain-Derived Neurotrophic Factor; Decitabine; Depression; Disease Models, Animal; DNA Methylation; Hindlimb Suspension; Hippocampus; Imipramine; Male; Mice; Rats; Swimming

2011
Transplantation of induced bone marrow mesenchymal stem cells improves the cardiac function of rabbits with dilated cardiomyopathy via upregulation of vascular endothelial growth factor and its receptors.
    Experimental biology and medicine (Maywood, N.J.), 2011, Volume: 236, Issue:9

    Topics: Animals; Azacitidine; Blood Pressure; Bone Marrow Cells; Bone Marrow Transplantation; Cardiomyopathy, Dilated; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rabbits; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Vascular Endothelial Growth Factor A

2011
Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury.
    Brain research, 2011, Oct-18, Volume: 1418

    Topics: Analysis of Variance; Animals; Azacitidine; Chronic Disease; Constriction, Pathologic; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Functional Laterality; Gene Expression Regulation; Injections, Spinal; Male; Methyl-CpG-Binding Protein 2; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors

2011
TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma.
    EMBO molecular medicine, 2012, Volume: 4, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Animals; Antigens, Neoplasm; Azacitidine; Base Sequence; Cell Adhesion Molecules; Cell Line, Tumor; Decitabine; Disease Models, Animal; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation; Gene Silencing; Histocytochemistry; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Middle Aged; Models, Biological; Molecular Sequence Data; Receptor, IGF Type 1; Signal Transduction

2012
Effects of hepatocyte growth factor overexpressed bone marrow-derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts.
    Cell biochemistry and function, 2012, Volume: 30, Issue:7

    Topics: Animals; Azacitidine; Bone Marrow Cells; Cells, Cultured; Coronary Vessels; Disease Models, Animal; Female; Hemodynamics; Hepatocyte Growth Factor; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myocardial Infarction; Neovascularization, Physiologic; Rats; Rats, Wistar; Transfection; Ventricular Remodeling

2012
New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.
    Journal of molecular cell biology, 2013, Volume: 5, Issue:1

    Topics: Animals; Azacitidine; Curcumin; Decitabine; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Neoplastic Stem Cells; Orchiectomy; Prostatic Neoplasms; Receptors, Androgen; Signal Transduction; Xenograft Model Antitumor Assays

2013
Murine models of lupus induced by hypomethylated T cells (DNA hypomethylation and lupus…).
    Methods in molecular biology (Clifton, N.J.), 2012, Volume: 900

    Topics: Adoptive Transfer; Animals; Antibodies, Antinuclear; Azacitidine; Disease Models, Animal; DNA Methylation; Female; Humans; Immunoglobulin G; Immunoglobulin M; Lupus Erythematosus, Systemic; Mice; T-Lymphocytes

2012
Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:6

    Topics: Animals; Azacitidine; Blotting, Western; Catecholamine Plasma Membrane Transport Proteins; Decitabine; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Hypoglycemic Agents; Immunohistochemistry; Kidney; Kidney Neoplasms; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Knockout; Multiprotein Complexes; Organic Cation Transport Proteins; Organic Cation Transporter 2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 1 Protein; Tumor Cells, Cultured; Tumor Suppressor Proteins

2013
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Feb-01, Volume: 19, Issue:3

    Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Indoles; Methylation; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sulfonamides; Vemurafenib

2013
Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis.
    American journal of respiratory and critical care medicine, 2013, Feb-15, Volume: 187, Issue:4

    Topics: Animals; Azacitidine; Cells, Cultured; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenomics; Fibroblasts; Gene Expression; Humans; Idiopathic Pulmonary Fibrosis; Mice; Mice, Inbred C57BL; MicroRNAs; Real-Time Polymerase Chain Reaction; Repressor Proteins; RNA, Long Noncoding

2013
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
    Pharmacological research, 2003, Volume: 48, Issue:1

    Topics: Animals; Azacitidine; beta-Galactosidase; Cell Differentiation; Clone Cells; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Genetic Therapy; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Vitro Techniques; Mice; Rats; Simplexvirus; Thymidine Kinase; Transcriptional Activation; Transduction, Genetic; Transgenes; U937 Cells

2003
Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats.
    Experimental neurology, 2003, Volume: 183, Issue:2

    Topics: Adenoviridae; Adipose Tissue; Animals; Antigens, Differentiation; Azacitidine; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Disease Models, Animal; Graft Survival; Humans; Immunohistochemistry; Lateral Ventricles; Male; Neurons; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells; Treatment Outcome

2003
Murine models of lupus induced by hypomethylated T cells.
    Methods in molecular medicine, 2004, Volume: 102

    Topics: Adoptive Transfer; Animals; Antibodies, Antinuclear; Autoimmunity; Azacitidine; CD4-Positive T-Lymphocytes; Cell Line; Disease Models, Animal; DNA Methylation; Female; Humans; Immunoglobulin G; Immunoglobulin M; Lupus Erythematosus, Systemic; Mice; Mice, Inbred AKR; Mice, Inbred DBA

2004
The in vitro and in vivo effects of re-expressing methylated von Hippel-Lindau tumor suppressor gene in clear cell renal carcinoma with 5-aza-2'-deoxycytidine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-15, Volume: 10, Issue:20

    Topics: Adenocarcinoma, Clear Cell; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; Disease Models, Animal; DNA Methylation; Gene Silencing; Humans; Kidney Neoplasms; Mice; Pyrimidine Nucleosides; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein

2004
Galectin-1 induces skeletal muscle differentiation in human fetal mesenchymal stem cells and increases muscle regeneration.
    Stem cells (Dayton, Ohio), 2006, Volume: 24, Issue:8

    Topics: Adult; Animals; Azacitidine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Disease Models, Animal; Fetal Blood; Fetal Stem Cells; Galectin 1; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred mdx; Mice, Knockout; Mice, SCID; Muscle, Skeletal; Muscular Dystrophy, Animal; Regeneration; Transplantation, Heterologous

2006
Effect of 6-azacytidine on the course of experimental adenoviral infection in newborn Syrian hamsters.
    Journal of chemotherapy (Florence, Italy), 2007, Volume: 19, Issue:1

    Topics: Adenoviridae Infections; Adenoviruses, Human; Animals; Animals, Newborn; Antiviral Agents; Azacitidine; Cricetinae; Disease Models, Animal; Mesocricetus; Spleen

2007
5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Apr-01, Volume: 13, Issue:7

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Azacitidine; Castration; Combined Modality Therapy; Decitabine; Disease Models, Animal; Male; Mice; Mice, Transgenic; Neoplasms, Hormone-Dependent; Prostatic Neoplasms

2007
Interleukin-3 increases the incidence of 5-azacytidine-induced thymic lymphomas in pBOR-Il-3 mice.
    Cellular immunology, 1996, Oct-10, Volume: 173, Issue:1

    Topics: Animals; Azacitidine; Carcinogens; CD3 Complex; CD4 Antigens; CD8 Antigens; Disease Models, Animal; Female; Gene Rearrangement, T-Lymphocyte; Incidence; Interleukin-3; Male; Mice; Mice, Transgenic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymus Neoplasms

1996
5-azacytidine treatment induces autoimmune vitiligo in parental control strains of the Smyth line chicken model for autoimmune vitiligo.
    Clinical immunology and immunopathology, 1996, Volume: 81, Issue:2

    Topics: Animals; Autoimmune Diseases; Azacitidine; Body Weight; Chickens; Disease Models, Animal; Erythrocyte Count; Feathers; Incidence; Leukocyte Count; Lymphocyte Activation; Lymphoid Tissue; Organ Size; Vitiligo

1996
Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
    Molecular and cellular biology, 1997, Volume: 17, Issue:3

    Topics: Amino Acid Sequence; Animals; Azacitidine; Base Sequence; Carrier Proteins; Cloning, Molecular; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; Disease Models, Animal; DNA Methylation; Exons; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Molecular Sequence Data; Proteins; Rats; Rats, Inbred F344; Sequence Analysis, DNA; Sequence Deletion; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tumor Suppressor Protein p14ARF

1997
Analysis of the effect of endogenous viral genes in the Smyth line chicken model for autoimmune vitiligo.
    The American journal of pathology, 2000, Volume: 156, Issue:3

    Topics: Animals; Autoimmune Diseases; Azacitidine; Blotting, Northern; Chickens; Deoxyribonuclease HindIII; Deoxyribonucleases, Type II Site-Specific; Disease Models, Animal; DNA; DNA Fingerprinting; DNA Methylation; Endogenous Retroviruses; Female; Fibroblasts; Genes, Viral; In Situ Hybridization, Fluorescence; Male; Pedigree; Polymorphism, Restriction Fragment Length; RNA Viruses; RNA, Viral; Vitiligo

2000
Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly.
    Anatomy and embryology, 2002, Volume: 205, Issue:1

    Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Azacitidine; Brain; Disease Models, Animal; Female; Male; Mice; Mice, Inbred ICR; Morphogenesis; Pregnancy

2002
A new hamster fibrosarcoma model for in vitro/in vivo evaluation of cancer chemotherapeutic agents.
    Medical and pediatric oncology, 1976, Volume: 2, Issue:3

    Topics: Ancitabine; Animals; Antineoplastic Agents; Azacitidine; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Cricetinae; Cytarabine; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrosarcoma; Mesocricetus; Sarcoma, Experimental

1976
Comparison of the incidence of 5-azacytidine-induced exencephaly between MT/HokIdr and Slc:ICR mice.
    Teratology, 1990, Volume: 41, Issue:2

    Topics: Anencephaly; Animals; Azacitidine; Brain; Disease Models, Animal; Embryonic and Fetal Development; Female; Fetal Death; In Vitro Techniques; Mice; Mice, Inbred ICR; Neural Tube Defects; Pregnancy; Species Specificity

1990
A two-stage therapeutic design in the spontaneous AKR lymphoma system.
    Cancer research, 1972, Volume: 32, Issue:6

    Topics: Amides; Animals; Antineoplastic Agents; Azacitidine; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Female; Imidazoles; Lymphoma; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Oxazines; Prednisone; Remission, Spontaneous; Time Factors; Triazenes; Vincristine

1972