azacitidine has been researched along with Colorectal Cancer in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (5.67) | 18.2507 |
| 2000's | 61 (43.26) | 29.6817 |
| 2010's | 63 (44.68) | 24.3611 |
| 2020's | 9 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Hosokawa, M; Iwakawa, S; Ogawara, KI; Seiki, R | 1 |
| Augustin, RC; Bahary, N; Beasley, HS; Chu, E; Hartman, DJ; Herman, JG; Krishnamurthy, A; Kuang, C; Lee, JJ; Lin, Y; Marks, SM; Ohr, J; Pai, RK; Park, Y; Rhee, JC; Seigh, L; Shuai, Y; Sun, W; Zarour, HM | 1 |
| Chen, N; Dai, L; Fang, C; Jiang, Z; Li, Y; Liu, B; Yin, X; Yin, Y; Zhang, B | 1 |
| Borlak, J; Liu, L; Tang, Z | 1 |
| Chen, J; Chen, Z; Chi, J; Deng, M; Hu, J; Huang, L; Li, J; Li, Q; Luo, Z; Tao, K; Wang, G; Wang, L; Wang, Z; Zhang, H; Zhou, C | 1 |
| Chen, N; Cheng, L; Dai, L; Deng, H; Dong, Z; Fang, C; Fu, J; Ji, Y; Li, J; Liu, Y; Shi, G; Su, X; Wang, H; Wang, W; Yang, Y; Yu, Y; Zhang, H; Zhang, S | 1 |
| Alizadeh Naini, M; Ashktorab, H; Brim, H; Carethers, JM; Erfani, M; Hosseini, SV; Koi, M; Mokarram, P; Mokhtari, M; Taghavi, A; Tahmasebi, K; Zamani, M | 1 |
| Ban, D; Gu, M; Hua, S; Ji, H; Wang, Y | 1 |
| Li, H; Li, Z; Lu, Y; Shan, S; Shi, J; Zhang, X | 1 |
| Ahuja, N; Anders, RA; Azad, NS; Bever, KM; Christmas, B; Diaz Rivera, EA; Jaffee, EM; Judkins, C; Liu, M; Nauroth, JM; Rosner, GL; Thomas, DL; Thompson, ED; Zhang, J; Zheng, L; Zhu, Q | 1 |
| A Guzzetta, A; Abdelfatah, E; Ahuja, N; Azad, N; B Baylin, S; Hu, Y; Kerner, Z; Sharma, A; Singh, J; Vatapalli, R; Wyatt McMahon, K; Yerram, S; Zahnow, C | 1 |
| Evers, BM; Kim, JT; Weiss, HL | 1 |
| Chen, Q; Hu, YH; Li, XM; Li, XN; Lin, C; Lu, YX; Zhang, F; Zhang, JM; Zhang, W; Zhang, WJ | 1 |
| Belardelli, F; Buoncervello, M; Canini, I; Capone, I; De Angelis, M; Del Vecchio, G; Fragale, A; Gabriele, L; Giuliani, C; Leone, C; Licursi, V; Negri, R; Parlato, S; Presutti, C; Romagnoli, G; Toschi, E | 1 |
| Feng, S; Gao, J; Tong, H; Wen, S; Zhang, L; Zhou, H | 1 |
| Cheng, YW; Huang, CC; Huang, TC; Ko, CY; Lee, KH; Lee, PT; Lee, YC; Lin, DY; Wu, MH | 1 |
| Gabius, HJ; Gebert, J; Katzenmaier, EM; Kloor, M; Kopitz, J | 1 |
| Gu, J; Liu, H; Wang, G; Xiong, C | 1 |
| Alibés, A; Alonso, S; Fece de la Cruz, F; González, B; Samuelsson, JK | 1 |
| Biyani, N; Bolt, MJ; Chlenski, A; Forde, M; Jutzy, JMS; Khodarev, NN; Oshima, G; Pitroda, SP; Poli, EC; Posner, MC; Weichselbaum, RR | 1 |
| Boucher, K; Burr, L; Davidson, C; Garrido-Laguna, I; Gilcrease, W; Jakubowski, L; Jones, D; McGregor, KA; Morrell, G; Olpin, JD; Sharma, S; Soldi, R; Wade, M; Weis, J | 1 |
| Bazzoli, F; Bianchi, P; Boland, CR; Ceccarelli, C; Chieco, P; D'Angelo, L; Fini, L; Garcia, M; Laghi, L; Malfertheiner, P; Paterini, P; Piazzi, G; Ricciardiello, L; Selgrad, M | 1 |
| Chang, WY; Hyun, JW; Kang, KA; Kim, GY; Kim, HS; Kim, KC; Na, SY; Zhang, R | 1 |
| Baylin, SB; Bernards, R; Bruurs, L; Cai, Y; de Lint, K; de Rink, I; Geutjes, EJ; Mohammad, H; Roepman, P; van Blijswijk, J; Wang, W; Yu, LR | 1 |
| Hu, J; Jiang, B; Liang, Y; Wang, B; Wang, X; Wang, Z; Xu, B; Zhang, Y; Zhou, J | 1 |
| Bujnicka, KE; Horbacka, K; Jagodziński, PP; Krokowicz, P; Rawluszko, AA | 1 |
| Ashktorab, H; Brim, H; Brodeur, GM; Fatemi, M; Paul, TA; Shokrani, B | 1 |
| Kang, HJ; Kim, HS; Kim, J; Kim, N; Kim, SJ; Lee, JO; Lee, SK; Lee, YW; Moon, JW; Park, SH | 1 |
| Flis, K; Flis, S; Gnyszka, A | 1 |
| Bourke, MJ; Hawkins, NJ; Hesson, LB; Nunez, AC; Perera, D; Pimanda, JE; Sieber, OM; Sloane, MA; Ward, RL; Wong, JW | 1 |
| Blosser, RL; Diaz, LA; Kim, K; Kinzler, KW; Li, Z; Liu, Q; Papadopoulos, N; Skora, AD; Tam, AJ; Vogelstein, B; Zhou, S | 1 |
| Bae, JH; Heo, K; Kim, JA; Kim, JG; Yang, K; Yi, JM | 1 |
| Kouraklis, G; Nebiker, CA; Tampaki, EC; Tampakis, A | 1 |
| Buisine, MP; Copin, MC; Crépin, M; Leteurtre, E; Mariette, C; Porchet, N; Renaud, F; Stechly, L; Truant, S; Van Seuningen, I; Vincent, A | 1 |
| Aguila, B; Duan, W; Gao, L; Kalvala, A; Otterson, GA; Reese, T; Villalona-Calero, MA | 1 |
| Jiang, P; Lee, S; Lee, W; Xiang, Y; Yu, G; Zhang, C; Zhang, Y; Zhu, Z | 1 |
| Choi, JH; Kim, GJ; Kim, HS; Kim, J; Kim, N; Lee, HJ; Lee, JO; Lee, SK; Lee, YW; Moon, JW; Park, SH; Seo, JS | 1 |
| Hosokawa, M; Iwakawa, S; Tanaka, S; Ueda, K | 1 |
| Hosokawa, M; Iwakawa, S; Ueda, K | 1 |
| Licht, JD | 1 |
| Danesh, A; De Carvalho, DD; Han, H; Jones, PA; Liang, G; Loo Yau, H; O'Brien, C; Pugh, TJ; Roulois, D; Shen, SY; Singhania, R; Wang, Y | 1 |
| Bandura, AS; Horbacka, K; Horst, N; Jagodziński, PP; Krokowicz, P; Rawłuszko-Wieczorek, AA; Świderska, M | 1 |
| Feng, S; Gao, X; Jiang, T; Qin, W; Shi, W; Sun, Y; Tang, C | 1 |
| Hao, S; Ji, JJ; Kang, XC; Qin, L; Wang, GX; Zhao, LD; Zheng, WW | 1 |
| Belardelli, F; Biffoni, M; Buccarelli, M; Buoncervello, M; Canini, I; Capone, I; Falchi, M; Fragale, A; Gabriele, L; Lucchetti, D; Macchia, D; Musella, M; Parlato, S; Romagnoli, G; Sanchez, M; Sgambato, A; Spada, M; Toschi, E; Vitiani, LR | 1 |
| Chen, ML; Gao, BQ; Hao, S; Kang, XC; Yang, F; Yang, QH; Zheng, WW | 1 |
| Amler, L; Bourgon, R; Frierson, H; Fu, L; Fuentes, E; Hampton, GM; Kabbarah, O; Lackner, MR; Lu, S; Moskaluk, C; Okrah, K; Penuel, E; Pirzkall, A; Qu, X; Rumpel, C; Sandmann, T; Tabernero, J; Walter, K; Wang, Y | 1 |
| Aguila, B; Amann, J; Dotts, K; Duan, W; Gao, L; Kalvala, A; Nana-Sinkam, SP; Otterson, GA; Rahman, M; Villalona-Calero, MA; Wang, QE; Zhou, X | 1 |
| Broom, B; Eng, C; Ensor, J; Feng, T; Fogelman, D; Hamilton, S; Issa, JP; Kee, B; Kopetz, S; LaFramboise, T; Lee, MS; Lutterbaugh, J; Manyam, G; Markowitz, SD; Mazard, T; Moinova, H; Morris, V; Overman, MJ; Shroff, RT | 1 |
| Chen, S; Huang, W; Li, Y; Liu, R; Mao, X; Shi, W; Shuai, W; Wu, J; Ye, Z; Zhuang, L; Zuo, Z | 1 |
| Fidyt, K; Fiedorowicz, A; Kalas, W; Pawlak, A; Strzadala, L; Ziolo, E | 1 |
| Aoki, H; Harada, T; Kai, M; Kitajima, H; Maruyama, R; Nakase, H; Niinuma, T; Sasaki, Y; Sugai, T; Suzuki, H; Tokino, T; Toyota, M; Yamamoto, E | 1 |
| Adkins, D; Ahuja, N; Azad, NS; Bahary, N; Baylin, S; Brown, T; Donehower, R; Easwaran, H; El-Khoueiry, A; Erlichman, C; Flynn, P; Jones, PA; Kamel, I; Kim, G; Laird, PW; Medvari, P; Oberg, AL; Picus, J; Piekarz, R; Pitot, HC; Sharma, A; Shen, H; Weisenberger, DJ; Yin, J | 1 |
| Cruickshanks, HA; Lund, JN; McMillan, LE; Meehan, RR; Parr, C; Peacock, O; Saddington, S; Sanner, J; Tufarelli, C; Vafadar-Isfahani, N; Yeo, Z | 1 |
| Allgayer, H; Mudduluru, G | 1 |
| Chan, MT; Cheyette, BN; Jiang, X; Kivimäe, S; Lee, PL; Li, J; Liu, ET; Stanton, LW; Tan, J; Yang, X; Yu, Q; Zhuang, L | 1 |
| Chiba, H; Nakayama, F; Sawada, N; Semba, S; Usami, Y; Yokozaki, H | 1 |
| Eu, KW; Hong, Y; Ismail, TM; Liu, Y; Wong, Y; Zhao, Y | 1 |
| Fang, J; Sun, D; Tian, XQ; Xiong, H; Zhang, Y; Zhao, S | 1 |
| Ahuja, N; Baylin, SB; Costello, JF; Easwaran, H; Eberhart, CG; Glöckner, SC; Herman, JG; James, CD; Laterra, J; Lin, S; Ohm, JE; Riggins, G; Schuebel, KE; Tsai, HC; Vescovi, AL; Yi, JM | 1 |
| Deng, T; Zhang, Y | 1 |
| Shaffer, JM; Smithgall, TE | 1 |
| Huang, Q; Lai, MD; Lin, J; Shao, LN; Zhu, YM | 1 |
| Choi, E; Deng, G; Kakar, S; Kim, YS; Okudiara, K; Sleisenger, MH | 1 |
| Dai, Q; Fang, JY; Li, XQ; Sun, DF; Tian, XQ; Xiong, H; Zhang, YJ; Zhao, SL | 1 |
| Boyd, AW; Doecke, J; Herath, NI; Leggett, BA; Spanevello, MD | 1 |
| Epstein, RJ; Xiong, J | 1 |
| Banerjee, D; Bertino, JR; Humeniuk, R; Mishra, PJ | 1 |
| Drew, PA; Jones, ME; Smith, E | 1 |
| An, CH; Cho, HJ; Kang, WK; Kim, JI; Kim, JS; Kim, KH; Kim, SY; Oh, ST | 1 |
| Agirre, X; Bandres, E; Bitarte, N; Garcia-Foncillas, J; Prosper, F; Ramirez, N; Roman-Gomez, J; Zarate, R | 1 |
| Cortesi, F; Crea, F; Danesi, R; Del Tacca, M; Gallegos Ruiz, MI; Giovannetti, E; Mey, V; Nannizzi, S; Peters, GJ; Ricciardi, S | 1 |
| Akashi, H; Igarashi, S; Imai, K; Issa, JP; Itoh, F; Kai, M; Maruyama, R; Nojima, M; Sasaki, Y; Shen, L; Shinomura, Y; Sugai, T; Suzuki, H; Tokino, T; Toyota, M; Watanabe, Y; Yamamoto, E; Yamamoto, H | 1 |
| Chin, K; Chua, CL; Eu, KW; Gray, JW; Ho, YM; Hong, GS; Kuo, WL; Lee, AS; Lie, DK; Ong, DC; Rudduck, C; Seow-Choen, F; Tan, PH; Wong, CY | 1 |
| Hazama, S; Higaki, S; Hinoda, Y; Hirata, H; Kaneko, S; Mitomori, S; Nishioka, M; Oka, M; Okada, T; Okayama, N; Sakai, K; Sakaida, I; Suehiro, Y; Ueno, K | 1 |
| Fu, J; Grusby, MJ; Jiang, J; Qu, Z; Smithgall, TE; Xiao, G; Yan, P | 1 |
| Chen, GQ; Chen, HM; Chen, ZF; Du, W; Fang, JY; Han, ZG; Liang, QC; Su, WY; Xiong, H | 1 |
| Guan, M; Li, J; Li, M; Lin, Y; Liu, C; Liu, W; Lu, Y; Ma, W; Su, B | 1 |
| Albertini, V; Benhattar, J; Bosman, FT; Catapano, CV; Ciernik, IF; Forrer, C; Hofstetter, B; Niemierko, A; Pruschy, M | 1 |
| Guan, M; Li, J; Li, M; Lin, Y; Liu, C; Liu, W; Lu, Y; Su, B; Ye, C; Zhang, X | 1 |
| Guo, Q; Li, G; Liu, M; Peng, Y; Shen, S; Wang, X | 1 |
| Kim, KT; Mossman, D; Scott, RJ | 1 |
| Anti, M; Beggs, A; Bevilacqua, G; de Palo, M; Francesconi, S; Gomes, V; Lessi, F; Macarone Palmieri, R; Segditsas, S; Tomlinson, I | 1 |
| Gazdar, A; Kawaguchi, Y; Nonaka, K; Okumura, N; Osada, S; Takahashi, T; Tokuyama, Y; Yamaguchi, K; Yoshida, K | 1 |
| Feng, L; Wu, Y; Xie, Y; Zhang, H | 1 |
| Bernardini, S; Corso, G; Cretella, M; Del Vecchio Blanco, G; Di Cecilia, S; Federici, G; Formosa, A; Kalimutho, M; Marrelli, D; Pallone, F; Roviello, F; Sileri, P | 1 |
| Chen, HM; Du, W; Fang, JY; Hong, J; Tang, JT; Wang, JL; Wang, YC; Xiong, H; Zhao, SL | 1 |
| Mossman, D; Scott, RJ | 1 |
| Astudillo, A; Ballestar, E; Calvanese, V; Fernández, AF; Ferrero, C; Fraga, MF; Hernando, H; Huidobro, C; Mangas, C; Martínez-Camblor, P; Obaya, AJ; Parra-Blanco, A; Rodrigo, L; Rodríguez, RM; Suárez-Fernández, L; Urdinguio, RG | 1 |
| Altendorf-Hofmann, A; Chen, Y; Hotovy, S; Knösel, T; Petersen, I; Settmacher, U | 1 |
| Chen, HQ; Liang, Y; Ma, YL; Moyer, MP; Qin, HL; Shen, TY; Shi, CZ; Wang, F; Yang, YZ; Zhang, HZ; Zhang, P | 1 |
| Esteban, S; Fernandez-Suarez, A; Maestro, M; Morente, M; Moya, P; Sánchez-Carbayo, M | 1 |
| Ha, CS; Rankin, EB; Suh, ER; Toyota, M; Traber, PG | 1 |
| Harada, M; Ito, M; Itoh, N; Kimura, W; Moriya, T; Semba, S; Yamakawa, M; Youssef, EM | 1 |
| Issa, JP; Kondo, Y; Shen, L | 1 |
| Baylin, SB; Eguchi, S; Fahrner, JA; Herman, JG | 1 |
| Kim, K; Murnane, MJ; Sengupta, PK; Smith, BD; Smith, EM | 1 |
| Arnold, CN; Boland, CR; Goel, A | 1 |
| Guan, X; Higuchi, K; Komiyama, Y; Masumoto, J; Miyata, K; Sagara, J; Takeoka, M; Taniguchi, S; Yokoyama, T | 1 |
| Akino, K; Imai, K; Issa, JP; Itoh, F; Kikuchi, T; Mita, H; Murai, M; Obata, T; Ogi, K; Sasaki, Y; Satoh, A; Suzuki, H; Tokino, T; Toyota, M | 1 |
| Dong, Q; Fang, XM; Peng, JP; Sun, LF; Zheng, S | 1 |
| Deng, G; Kim, YS; Pong, E; Sleisenger, M; Song, GA | 1 |
| Bilchik, AJ; Fujimoto, A; Hoon, DS; Shinozaki, M; Takeuchi, H; Umetani, N | 1 |
| Akino, K; Endo, T; Hinoda, Y; Imai, K; Kusano, M; Mita, H; Murai, M; Sasaki, Y; Satoh, A; Suzuki, H; Takahashi, F; Tokino, T; Toyota, M; Ueno, M; Yanagihara, K | 1 |
| Kohno, T; Nakano, T; Nishioka, M; Ohwada, S; Otsuka, A; Tani, M; Yokota, J | 1 |
| Capellà, G; Clark, SJ; Frigola, J; Moreno, V; Muñoz, M; Peinado, MA | 1 |
| Ikeda, Y; Inoue, H; Mimori, K; Mori, M; Murayama, S; Ogawa, K; Okamoto, M; Saku, M; Tanaka, F; Utsunomiya, T; Yamashita, K | 1 |
| Chuang, JC; Jones, PA; Kwan, JM; Li, TW; Liang, G; Yang, AS; Yoo, CB | 1 |
| Choi, YL; Fujiwara, SI; Hatanaka, H; Kaneda, R; Koinuma, K; Kurashina, K; Liu, W; Mano, H; Miyakura, Y; Nagai, H; Takada, S; Wada, T; Yamashita, Y | 1 |
| Hsi, LC; Lippman, SM; Wu, Y; Xi, X | 1 |
| Bell, I; Crawley, S; Deng, G; Gum, J; Kakar, S; Kim, YS; Matsuzaki, K; Mehta, KR; Nguyen, A; Sleisenger, MH; Tanaka, H; Terdiman, JP; Waldman, FM | 1 |
| Aguilera, O; Ballestar, E; Espada, J; Esteller, M; Fraga, MF; García, JM; González-Sancho, JM; Herranz, M; Muñoz, A; Paz, MF | 1 |
| Baba, H; Egami, H; Ikeda, K; Ishikawa, N; Iyama, K; Nakao, M; Ninomiya, Y; Sado, Y | 1 |
| Baylin, SB; Fahrner, JA; Greene, E; Jenuwein, T; Martens, J; McGarvey, KM | 1 |
| Ichimura, S; Mori, A; Nakazawa, K; Okochi-Takada, E; Ushijima, T; Wakabayashi, M; Yasugi, T | 1 |
| Choi, JS; Kim, IJ; Kim, KH; Ku, JL; Park, JG | 1 |
| Aburatani, H; Hayashi, H; Kaneda, A; Kaneshiro, K; Kozaki, T; Nagae, G; Sugisaki, H; Tsutsumi, S | 1 |
| Armentano, R; Caruso, ML; Pirrelli, M; Valentini, AM | 1 |
| Downes, CS; McGlynn, AP; McKelvey-Martin, VJ; McKerr, G; McNulty, H; O'Reilly, SL; Scott, J; Strain, JJ; Wasson, GR | 1 |
| Davie, JR; Diasio, RB; Guarcello, V; Li, L; Soong, R; Wang, K; Zhang, X | 1 |
| Iida, S; Kato, K; Morita, S; Sugihara, K; Takagi, Y; Uetake, H | 1 |
| Baek, JH; Chang, X; Dasgupta, S; Kim, MS; Moon, C; Nagpal, JK; Osada, M; Ratovitski, EA; Sidransky, D; Trink, B; Westra, WH; Woo, JH; Wu, G; Yamashita, K | 1 |
| Luo, J; Qi, J; Tao, WH; Zhu, YQ | 1 |
| Chung, DC; Kawasaki, T; Kirley, SD; Kwon, E; Lauwers, GY; Mino-Kenudson, M; Ogino, S; Park, DY; Rueda, BR; Sakamoto, H; Zukerberg, LR | 1 |
| Ethier, SP; Hanifi-Moghaddam, P; Hollestelle, A; Klijn, JG; Merajver, SD; Schutte, M; van den Ouweland, A; Wasielewski, M | 1 |
| Luo, J; Qi, J; Tao, WH; Zhang, JM; Zhu, YQ | 1 |
| Cheetham, S; Kennecke, H; Mesak, F; Owen, D; Tai, IT; Tang, MJ | 1 |
| Akiyoshi, T; Baba, K; Barnard, GF; Haraguchi, M; Inoue, H; Mimori, K; Mori, M; Nakashima, H; Shibuta, K; Tsuji, K; Ueo, H | 1 |
| Barletta, JM; Feinberg, AP; Rainier, S | 1 |
| Kinzler, KW; Lengauer, C; Vogelstein, B | 1 |
| Chae, HS; Chen, A; Deng, G; Hong, J; Kim, YS | 1 |
| Beck, NE; Bodmer, WF; Kim, HC; Mortensen, NJ; Tomlinson, IP; Wheeler, JM | 1 |
| Jones, PA; Laird, PW; Liang, G; Pao, MM; Tsai, YC; Xiong, Z | 1 |
| Bumke-Vogt, C; Foss, HD; Gratchev, A; Hanski, C; Hanski, ML; Hummel, M; Kobalz, U; Lammert, H; Mann, B; Mansmann, U; Riecken, EO; Siedow, A; Stein, H | 1 |
| Ashida, T; Fujiki, T; Fujiya, M; Honda, M; Kohgo, Y; Saitoh, Y; Tanabe, H; Watari, J | 1 |
| Chen, A; Deng, G; Kim, YS; Pong, E | 1 |
| Davis, CD; Uthus, EO | 1 |
| Brown, KD; Kim, WJ; Lataxes, TA; Shrivastav, M; Vo, QN | 1 |
| Abbruzzese, JL; Anzai, H; Frost, P | 1 |
| Abbruzzese, JL; Ajani, JA; Daugherty, K; Hubbard, KP; Levin, B; Pazdur, R | 1 |
| Allegra, CJ; Grem, JL | 1 |
2 review(s) available for azacitidine and Colorectal Cancer
| Article | Year |
|---|---|
Histone deacetylase inhibitors and colorectal cancer: what is new?
Topics: Antineoplastic Agents; Azacitidine; Colorectal Neoplasms; Combined Modality Therapy; Decitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Valproic Acid; Vorinostat | 2014 |
Chemotherapeutic agents for colorectal cancer with a defective mismatch repair system: the state of the art.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Pair Mismatch; Colorectal Neoplasms; Humans; Neoplasm Staging | 2006 |
7 trial(s) available for azacitidine and Colorectal Cancer
| Article | Year |
|---|---|
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Biomarkers; Colorectal Neoplasms; Epigenomics; Female; Humans; Immunotherapy; Male; Middle Aged; Neoplasm Metastasis | 2022 |
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biopsy; Cancer Vaccines; Colorectal Neoplasms; Combined Modality Therapy; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Epigenomics; Feasibility Studies; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunotherapy; Immunotherapy, Active; Leukocyte Common Antigens; Male; Middle Aged; Safety; Severity of Illness Index; Tumor Microenvironment | 2021 |
A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt) KRAS metastatic colorectal cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; ErbB Receptors; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Panitumumab; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins | 2013 |
Phase I/II study of azacitidine and capecitabine/oxaliplatin (CAPOX) in refractory CIMP-high metastatic colorectal cancer: evaluation of circulating methylated vimentin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Biomarkers, Tumor; Capecitabine; Colorectal Neoplasms; CpG Islands; Disease-Free Survival; DNA Methylation; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Vimentin | 2016 |
Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; Cell Line, Tumor; Cohort Studies; Colorectal Neoplasms; DNA Methylation; Drug Administration Schedule; Epigenesis, Genetic; Female; HCT116 Cells; Humans; Male; Middle Aged; Pyridines; Survival Analysis; Treatment Outcome | 2017 |
MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Blotting, Western; Cell Movement; Cell Proliferation; Chromatin Immunoprecipitation; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Primers; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Immunoenzyme Techniques; Luciferases; Lymphatic Metastasis; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2011 |
Phase II trial of fazarabine in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Azacitidine; Carcinoma; Colorectal Neoplasms; Drug Administration Schedule; Drug Evaluation; Humans; Male; Middle Aged | 1992 |
132 other study(ies) available for azacitidine and Colorectal Cancer
| Article | Year |
|---|---|
Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Curcumin; Cytidine Deaminase; Decitabine; Deoxycytidine Kinase; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Humans | 2021 |
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.
Topics: Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Demethylation; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Symporters | 2022 |
Combined inhibition of histone deacetylase and cytidine deaminase improves epigenetic potency of decitabine in colorectal adenocarcinomas.
Topics: Adenocarcinoma; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Cytidine Deaminase; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Prospective Studies; Tetrahydrouridine; Tumor Microenvironment; Tumor Suppressor Protein p53 | 2023 |
AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer.
Topics: Azacitidine; Caco-2 Cells; Carcinogenesis; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HEK293 Cells; HT29 Cells; Humans; Mucoproteins; Oncogene Proteins; Prognosis; Promoter Regions, Genetic; Signal Transduction; Up-Regulation | 2019 |
Temporal DNA methylation pattern and targeted therapy in colitis-associated cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Azoxymethane; bcl-Associated Death Protein; Carcinogenesis; Cell Line, Tumor; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Decitabine; Disease Models, Animal; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Male; Mice; Molecular Targeted Therapy; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Up-Regulation | 2020 |
Altered ARID1A expression in colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Colorectal Neoplasms; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Survival Rate; Transcription Factors; Tumor Cells, Cultured | 2020 |
Oxymatrine reduces expression of programmed death-ligand 1 by promoting DNA demethylation in colorectal cancer cells.
Topics: Alkaloids; Azacitidine; B7-H1 Antigen; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Demethylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; HCT116 Cells; Humans; Immune Checkpoint Inhibitors; Interferon-gamma; Quinolizines; RNA, Messenger | 2021 |
Inhibitory effect of bound polyphenol from foxtail millet bran on miR-149 methylation increases the chemosensitivity of human colorectal cancer HCT-8/Fu cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Proliferation; Colorectal Neoplasms; DNA Methylation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans; MicroRNAs; Polyphenols; Setaria Plant | 2021 |
Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells.
Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Azacitidine; Caco-2 Cells; Camptothecin; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Methylation; DNA Repair; Gene Expression; Gene Expression Profiling; HCT116 Cells; Humans; Irinotecan; Long Interspersed Nucleotide Elements; Mice; Mice, Inbred NOD; Mice, SCID | 2017 |
Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.
Topics: Adaptor Proteins, Vesicular Transport; Azacitidine; Carcinogenesis; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Promoter Regions, Genetic; Receptors, Neurotensin; Signal Transduction | 2017 |
Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
Topics: Animals; Azacitidine; Carcinogenesis; Cell Movement; Cell Proliferation; Colonic Neoplasms; Colorectal Neoplasms; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Low Density Lipoprotein Receptor-Related Protein-6; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Staging; RNA, Small Interfering; Tumor Suppressor Proteins; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2017 |
Antitumor Effects of Epidrug/IFNα Combination Driven by Modulated Gene Signatures in Both Colorectal Cancer and Dendritic Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Dendritic Cells; Depsipeptides; Gene Expression Regulation, Neoplastic; Humans; Interferon Regulatory Factor-7; Interferon Regulatory Factors; Interferon-alpha; Interferon-gamma; Nitric Oxide Synthase Type II; Receptors, Cytokine; Receptors, Interferon; Signal Transduction | 2017 |
Methylation of mitochondrial DNA displacement loop region regulates mitochondrial copy number in colorectal cancer.
Topics: Apoptosis; Azacitidine; Base Sequence; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Copy Number Variations; DNA Methylation; DNA, Mitochondrial; Epigenesis, Genetic; Humans; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid | 2017 |
Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells.
Topics: Apoptosis; Azacitidine; beta Catenin; Biomarkers, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; Humans; Protein Isoforms; RNA, Messenger; Wnt Signaling Pathway; Wnt-5a Protein | 2017 |
Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer.
Topics: Acetylation; Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cohort Studies; Colorectal Neoplasms; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epithelial Cells; Female; Galectins; Histones; Humans; Male; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Protein Isoforms | 2017 |
SATB2 targeted by methylated miR-34c-5p suppresses proliferation and metastasis attenuating the epithelial-mesenchymal transition in colorectal cancer.
Topics: 3' Untranslated Regions; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Matrix Attachment Region Binding Proteins; MicroRNAs; Middle Aged; Prognosis; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Transcription Factors | 2018 |
Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer.
Topics: Aged; Azacitidine; Biomarkers, Tumor; Calcium-Binding Proteins; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genetic Loci; Histone Code; Humans; Introns; Male; Middle Aged; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; RNA, Messenger; Transcription, Genetic; Up-Regulation; Wnt Proteins | 2018 |
DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs.
Topics: Animals; Azacitidine; Chromosomes, Human, Pair 14; Colorectal Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; Heterografts; Humans; Liver Neoplasms; MCF-7 Cells; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; RNA, Long Noncoding | 2019 |
Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers.
Topics: Aged; Azacitidine; beta Catenin; Caco-2 Cells; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HCT116 Cells; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Microsatellite Instability; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; RNA, Messenger; Wnt Proteins; Wnt Signaling Pathway | 2013 |
Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells.
Topics: Azacitidine; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Activation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase 1; Homeodomain Proteins; HT29 Cells; Humans; Hydrogen Peroxide; Oxidative Stress; Promoter Regions, Genetic; Reactive Oxygen Species; RNA, Messenger; Serine; Time Factors | 2013 |
The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.
Topics: Apoptosis; Autoantigens; Azacitidine; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Tumor Suppressor; HCT116 Cells; Histone Deacetylase 1; Histone Deacetylase 2; Humans; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Promoter Regions, Genetic; Protein Binding; Wnt Proteins | 2014 |
Epigenetic silencing of miR-126 contributes to tumor invasion and angiogenesis in colorectal cancer.
Topics: 3' Untranslated Regions; Azacitidine; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Cytidine Triphosphate; DNA Methylation; EGF Family of Proteins; Endothelial Growth Factors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Promoter Regions, Genetic; RNA, Messenger; Vascular Endothelial Growth Factor A | 2013 |
Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.
Topics: Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging | 2013 |
Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages.
Topics: Adenoma; Azacitidine; Black or African American; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Helicases; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Nerve Tissue Proteins; Promoter Regions, Genetic; Vorinostat | 2014 |
Identification of novel hypermethylated genes and demethylating effect of vincristine in colorectal cancer.
Topics: Aged; Antineoplastic Agents, Phytogenic; Azacitidine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Male; Middle Aged; RNA, Messenger; Sequence Analysis, DNA; Vincristine | 2014 |
DNA methyltransferase inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; DNA Damage; DNA-Cytosine Methylases; Enzyme Inhibitors; Fluorouracil; Humans; Membrane Potential, Mitochondrial; Organoplatinum Compounds; Oxaliplatin | 2014 |
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Topics: Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Aneuploidy; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Colon; Colorectal Neoplasms; CpG Islands; Decitabine; Epigenesis, Genetic; Gene Expression; Genes, Tumor Suppressor; Humans; Intestinal Mucosa; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Rectum; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Young Adult | 2014 |
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.
Topics: Animals; Antibodies, Monoclonal; Azacitidine; Benzamides; Cell Line, Tumor; Colorectal Neoplasms; Combined Modality Therapy; CTLA-4 Antigen; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Myeloid Cells; Neoplasm Metastasis; Phosphoinositide-3 Kinase Inhibitors; Programmed Cell Death 1 Receptor; Pyridines | 2014 |
Combination effect of epigenetic regulation and ionizing radiation in colorectal cancer cells.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Combined Modality Therapy; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; G1 Phase; HCT116 Cells; Humans; Mice; Mice, SCID; Radiation Tolerance; Radiation, Ionizing | 2014 |
MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Immunohistochemistry; Male; Microsatellite Instability; Middle Aged; Mucin 5AC; Mutation; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2015 |
Overexpression of Rad51C splice variants in colorectal tumors.
Topics: Adenocarcinoma; Alternative Splicing; Amino Acid Sequence; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Exons; Fanconi Anemia Complementation Group D2 Protein; Gene Expression Profiling; Humans; Matched-Pair Analysis; Microsatellite Instability; Molecular Sequence Data; Neoplasm Proteins; Promoter Regions, Genetic; Protein Isoforms; Protein Structure, Tertiary; RNA, Messenger; RNA, Neoplasm | 2015 |
Increased expression of protease-activated receptor 4 and Trefoil factor 2 in human colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Decitabine; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Microarray Analysis; Neoplasm Invasiveness; Peptides; Polymerase Chain Reaction; Receptors, Thrombin; Trefoil Factor-2 | 2015 |
Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma.
Topics: Adenocarcinoma; Aged; Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Decitabine; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 16; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering | 2015 |
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Exosomes; Humans; MicroRNAs; Neoplasm Invasiveness; Organoplatinum Compounds; Oxaliplatin | 2015 |
Cellular Uptake of Decitabine by Equilibrative Nucleoside Transporters in HCT116 Cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Decitabine; DNA Methylation; Equilibrative Nucleoside Transporter 1; Gene Expression; HCT116 Cells; Humans; Melanoma-Specific Antigens; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thioinosine; Uridine | 2015 |
DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Colorectal Neoplasms; DNA Methylation; Female; Humans; Interferon Type I; Melanoma | 2015 |
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; Colorectal Neoplasms; DEAD-box RNA Helicases; Decitabine; DNA Methylation; Endogenous Retroviruses; Humans; Interferon Regulatory Factor-7; Interferon-Induced Helicase, IFIH1; Mice; Receptors, Retinoic Acid; RNA, Double-Stranded; Signal Transduction | 2015 |
Effect of DNA methylation profile on OATP3A1 and OATP4A1 transcript levels in colorectal cancer.
Topics: Aged; Azacitidine; Butyric Acid; Caco-2 Cells; Colorectal Neoplasms; Decitabine; DNA Methylation; Down-Regulation; Estrone; Female; HCT116 Cells; Humans; Male; Middle Aged; Organic Anion Transporters; Promoter Regions, Genetic; RNA, Messenger | 2015 |
Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; CpG Islands; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic | 2015 |
Epigenetic silencing of miR-181b contributes to tumorigenicity in colorectal cancer by targeting RASSF1A.
Topics: 3' Untranslated Regions; Aged; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Humans; Male; MicroRNAs; Middle Aged; Tumor Suppressor Proteins | 2016 |
IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Depsipeptides; Epigenesis, Genetic; Humans; Interferon-alpha; Mice; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Xenograft Model Antitumor Assays | 2016 |
Promoter methylation and expression of SOCS-1 affect clinical outcome and epithelial-mesenchymal transition in colorectal cancer.
Topics: Azacitidine; Cell Movement; Colorectal Neoplasms; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Male; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Suppressor of Cytokine Signaling 1 Protein; Survival Analysis; Treatment Outcome | 2016 |
Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter.
Topics: Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; Disease Progression; DNA Methylation; Epiregulin; ErbB Receptors; Humans; Phosphorylation; Promoter Regions, Genetic | 2016 |
Rad51C-ATXN7 fusion gene expression in colorectal tumors.
Topics: Ataxin-7; Azacitidine; Cell Line, Tumor; Cloning, Molecular; Colorectal Neoplasms; Computer Simulation; DNA Methylation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Molecular Weight; Oncogene Proteins, Fusion | 2016 |
Olfactomedin 1 negatively regulates NF-κB signalling and suppresses the growth and metastasis of colorectal cancer cells.
Topics: Animals; Azacitidine; Biomarkers; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Decitabine; Disease-Free Survival; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; NF-kappa B; NF-kappaB-Inducing Kinase; Prognosis; Protein Serine-Threonine Kinases; Signal Transduction | 2016 |
Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Clonal Evolution; Colorectal Neoplasms; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Mutation; Neoplastic Stem Cells; Topoisomerase Inhibitors; Tumor Stem Cell Assay | 2016 |
TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.
Topics: Azacitidine; Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; HT29 Cells; Humans; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA, Small Interfering | 2016 |
Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.
Topics: Azacitidine; Colorectal Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Long Interspersed Nucleotide Elements; Promoter Regions, Genetic | 2017 |
The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation.
Topics: Amino Acid Motifs; Axl Receptor Tyrosine Kinase; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, Reporter; HeLa Cells; Humans; Mutagenesis, Site-Directed; Neoplasm Proteins; Oncogene Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Sp1 Transcription Factor; Sp3 Transcription Factor | 2008 |
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Adenosylhomocysteinase; Apoptosis; Azacitidine; beta Catenin; Colorectal Neoplasms; Decitabine; Dishevelled Proteins; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Promoter Regions, Genetic; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Wnt Proteins | 2008 |
Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.
Topics: Azacitidine; Cell Line, Tumor; Claudins; Colorectal Neoplasms; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression; Humans; Lymph Nodes; Lymphatic Metastasis; Membrane Proteins; Methylation; Neoplasm Staging; Promoter Regions, Genetic | 2008 |
Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines.
Topics: Acetylation; Antigens, CD; Azacitidine; Cadherins; Cell Line, Tumor; Chromatin Immunoprecipitation; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic | 2008 |
Epigenetic silencing of LRRC3B in colorectal cancer.
Topics: Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Silencing; Genes, Tumor Suppressor; Genetic Markers; Humans; In Vitro Techniques; Microarray Analysis; Neoplasm Proteins; Polymerase Chain Reaction | 2009 |
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Agents; Azacitidine; Brain Neoplasms; Caco-2 Cells; Carcinoma; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Glioblastoma; Glycoproteins; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Nude; Peptides; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Damage; DNA Methyltransferase 3A; DNA Modification Methylases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Humans | 2009 |
Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fes | 2009 |
[Hypomethylation of 5'CpG island of insulin-like growth factor binding protein-related protein 1 is associated with its overexpression in colorectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor Binding Proteins; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2008 |
Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gastrointestinal Tract; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Oncostatin M Receptor beta Subunit; Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2009 |
Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Azacitidine; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Colorectal Neoplasms; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; HCT116 Cells; Humans; Immunohistochemistry; Mice; Phosphoproteins; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden | 2009 |
Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival.
Topics: Azacitidine; Cell Line, Tumor; Colon; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Humans; Immunohistochemistry; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptor, EphA1 | 2009 |
Growth inhibition of human cancer cells by 5-aza-2'-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p14ARF | 2009 |
Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenomics; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Order; Humans; Mice; Mice, Nude; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Promoter Regions, Genetic; RNA Stability; Uridine; Xenograft Model Antitumor Assays | 2009 |
Quantitation of DNA methylation by melt curve analysis.
Topics: Algorithms; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA, Neoplasm; Esophageal Neoplasms; Hot Temperature; Humans; Immunohistochemistry; Nucleic Acid Denaturation; Oligonucleotides; Polymerase Chain Reaction; Promoter Regions, Genetic; Tissue Inhibitor of Metalloproteinase-3; Tumor Suppressor Proteins | 2009 |
The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines.
Topics: Azacitidine; Breast Neoplasms; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Radiation Dosage; Radiation-Sensitizing Agents | 2009 |
Epigenetic regulation of microRNA expression in colorectal cancer.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Lymphatic Metastasis; MicroRNAs; Phenylbutyrates; Promoter Regions, Genetic; Tumor Cells, Cultured | 2009 |
Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.
Topics: 14-3-3 Proteins; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Azacitidine; Camptothecin; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; DNA Damage; DNA Methylation; DNA Topoisomerases, Type I; Drug Therapy, Combination; Epigenesis, Genetic; Humans; Irinotecan; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2009 |
IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.
Topics: Adenocarcinoma; Adenoma; Azacitidine; Cell Line, Tumor; Cellular Senescence; Colorectal Neoplasms; Consensus Sequence; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Silencing; Genes, p53; Histones; Humans; Insulin-Like Growth Factor Binding Proteins; Neoplasm Proteins; Phenotype; Proto-Oncogene Proteins B-raf; Recombinant Fusion Proteins; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2010 |
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 11; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Guanine Nucleotide Exchange Factors; Humans; Hydroxamic Acids; Male; Nucleic Acid Hybridization; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Rho Guanine Nucleotide Exchange Factors; Transfection; Tumor Suppressor Proteins | 2009 |
TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Azacitidine; Case-Control Studies; Cell Line, Tumor; Chromosome Mapping; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Intestinal Mucosa; Linear Models; Male; Middle Aged; Nuclear Proteins; Polymerase Chain Reaction; Prognosis; Sequence Analysis, DNA; Statistics, Nonparametric; Twist-Related Protein 1 | 2010 |
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
Topics: Animals; Azacitidine; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Female; HCT116 Cells; HT29 Cells; Humans; LIM Domain Proteins; Mice; Mice, SCID; Microfilament Proteins; NF-kappa B; Transplantation, Heterologous; Up-Regulation | 2010 |
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; G2 Phase; Gene Expression Regulation, Enzymologic; Humans; Janus Kinase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 6; STAT3 Transcription Factor; STAT5 Transcription Factor; Transcription, Genetic | 2009 |
Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: application in colorectal cancer.
Topics: A Kinase Anchor Proteins; Azacitidine; Case-Control Studies; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Humans; Linear Models; Nucleic Acid Denaturation; Polymerase Chain Reaction; Promoter Regions, Genetic; Reproducibility of Results; Time Factors | 2010 |
Impact of genomic methylation on radiation sensitivity of colorectal carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Deletion; Humans; MutL Protein Homolog 1; Nuclear Proteins; Radiation Tolerance; Radiation-Sensitizing Agents | 2010 |
Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with Duke's stage.
Topics: A Kinase Anchor Proteins; Azacitidine; Base Sequence; Biomarkers, Tumor; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Primers; DNA, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Molecular Sequence Data; Neoplasm Staging; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Transition Temperature | 2010 |
NGX6 gene mediated by promoter methylation as a potential molecular marker in colorectal cancer.
Topics: Age Factors; Aged; Azacitidine; Biomarkers, Tumor; Chi-Square Distribution; Cloning, Molecular; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HT29 Cells; Humans; Male; Membrane Proteins; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Transfection; Tumor Suppressor Proteins | 2010 |
Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists.
Topics: Acetylation; Apoptosis; Azacitidine; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
Topics: Azacitidine; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Immediate-Early Proteins; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer.
Topics: Azacitidine; Biomarkers, Tumor; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Core Binding Factor Alpha 3 Subunit; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, p16; HCT116 Cells; Humans; Neoplasm Proteins; Poly-ADP-Ribose Binding Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sulfotransferases; Ubiquitin-Protein Ligases | 2010 |
Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma; Cell Line, Tumor; Colorectal Neoplasms; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Molecular Sequence Data; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2011 |
Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; Disease Progression; DNA Methylation; Feces; Female; Gene Silencing; Humans; Male; MicroRNAs; Middle Aged | 2011 |
Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Colorectal Neoplasms; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Real-Time Polymerase Chain Reaction; Transcriptional Activation | 2011 |
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; HCT116 Cells; HT29 Cells; Humans; Male; Middle Aged; Promoter Regions, Genetic; Transfection | 2012 |
Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.
Topics: Aged; Aged, 80 and over; Azacitidine; CDX2 Transcription Factor; Cell Line, Tumor; Colorectal Neoplasms; Desmocollins; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Homeodomain Proteins; Humans; Immunohistochemistry; Male; Multivariate Analysis; Paired Box Transcription Factors; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis | 2012 |
SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer.
Topics: Azacitidine; Base Sequence; Cell Proliferation; Chi-Square Distribution; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Knockdown Techniques; Gene Silencing; HCT116 Cells; HT29 Cells; Humans; Kaplan-Meier Estimate; Male; MicroRNAs; Middle Aged; Molecular Sequence Data; Multivariate Analysis; Neoplasm Invasiveness; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transfection | 2013 |
KiSS-1 methylation and protein expression patterns contribute to diagnostic and prognostic assessments in tissue specimens for colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Colorectal Neoplasms; Disease Progression; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kisspeptins; Male; Middle Aged; Molecular Sequence Data; Prognosis | 2013 |
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines.
Topics: Animals; Azacitidine; Base Sequence; Blotting, Western; Cloning, Molecular; Colorectal Neoplasms; Cosmids; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; HeLa Cells; Humans; Mice; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sulfites; Transfection; Tumor Cells, Cultured | 2002 |
Down-regulation of PIK3CG, a catalytic subunit of phosphatidylinositol 3-OH kinase, by CpG hypermethylation in human colorectal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Chromones; Chromosomes, Human, Pair 7; Colorectal Neoplasms; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Down-Regulation; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein Subunits; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2002 |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Tumor Cells, Cultured | 2003 |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers.
Topics: Azacitidine; Base Sequence; Collagen Type I; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Polymerase Chain Reaction; RNA, Messenger; Transcription Initiation Site; Transcriptional Activation; Tumor Cells, Cultured | 2003 |
Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines.
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Base Pair Mismatch; Blotting, Western; Carrier Proteins; Cloning, Molecular; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Enzyme Inhibitors; Fluorouracil; Humans; Immunoblotting; Kruppel-Like Transcription Factors; Microsatellite Repeats; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 2003 |
Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Azacitidine; CARD Signaling Adaptor Proteins; Case-Control Studies; Caspase 1; Caspases; Colorectal Neoplasms; Cytoskeletal Proteins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; DNA, Neoplasm; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Male; Middle Aged; Polymerase Chain Reaction; Proteins; Sulfites; Tumor Cells, Cultured | 2003 |
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Separation; Chromatin; Colorectal Neoplasms; CpG Islands; Decitabine; Depsipeptides; DNA Methylation; Doxorubicin; Flow Cytometry; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Models, Genetic; Neuropeptides; Oligopeptides; Polymerase Chain Reaction; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Sulfites | 2003 |
[The study of 5-Aza-2'-deoxycytidine on transcription regulation of p16/CDKN2 gene demethylation in RKO human colorectal cell line].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Genes, p16; Humans; Immunohistochemistry; Molecular Sequence Data; RNA, Messenger; Transcription, Genetic | 2003 |
Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor.
Topics: Adenomatous Polyposis Coli Protein; Azacitidine; CCAAT-Binding Factor; Cell Line, Tumor; Chromatin; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, APC; Humans; Luciferases; Promoter Regions, Genetic; Protein Conformation; RNA, Messenger; Transfection; Up-Regulation | 2004 |
Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Carcinoma; Cell Differentiation; Cell Line, Tumor; Colon; Colorectal Neoplasms; Disease Progression; DNA Methylation; DNA Primers; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Inhibitor of Differentiation Protein 2; Male; Middle Aged; Models, Genetic; Neoplasms; Polymerase Chain Reaction; Prognosis; Repressor Proteins; Risk; RNA, Messenger; Sequence Analysis, DNA; Sulfites; Time Factors; Transcription Factors | 2004 |
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.
Topics: Acetylation; Azacitidine; Base Sequence; Blotting, Western; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Histones; Humans; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sequence Analysis, DNA; Stomach Neoplasms | 2005 |
Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer.
Topics: Acetylation; Azacitidine; Base Sequence; Cell Proliferation; Chromosomes, Human, Pair 22; Colorectal Neoplasms; Decitabine; DNA Primers; Humans; Immunoprecipitation; Mutation; Myosins; Tumor Suppressor Proteins | 2005 |
Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy.
Topics: Adenoma; Aged; Aneuploidy; Azacitidine; Colon; Colorectal Neoplasms; Cytochrome P-450 Enzyme System; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, ras; Humans; Intramolecular Oxidoreductases; Male; Middle Aged; Mutation; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 2005 |
Genomic screens for genes upregulated by demethylation in colorectal cancer: possible usefulness for clinical application.
Topics: Aged; Antimetabolites, Antineoplastic; Apolipoproteins; Apolipoproteins D; Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genome, Human; HT29 Cells; Humans; Immunohistochemistry; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Survival Analysis; Up-Regulation | 2005 |
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Transitional Cell; Catechin; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Decitabine; Deoxycytidine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Silencing; HT29 Cells; Humans; Hydralazine; Male; Procainamide; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Axin Protein; Azacitidine; Benzothiazoles; Carrier Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Colorectal Neoplasms; CpG Islands; Cytoskeletal Proteins; Diamines; DNA Methylation; DNA Repair; DNA, Complementary; Epigenesis, Genetic; Female; Gene Silencing; Humans; Male; Microsatellite Repeats; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Organic Chemicals; Quinolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Up-Regulation | 2006 |
The methyltransferase inhibitor 5-aza-2-deoxycytidine induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Arachidonate 15-Lipoxygenase; Azacitidine; Blotting, Western; Caspase 3; Caspases; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Fragmentation; DNA Primers; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; RNA, Small Interfering; Time Factors; Transcription, Genetic; Up-Regulation | 2005 |
Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Chromatin; Chromosomal Instability; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Immunoprecipitation; Loss of Heterozygosity; Microsatellite Repeats; Protein Conformation | 2006 |
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenomatous Polyposis Coli Protein; Animals; Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Epithelium; Genes, Tumor Suppressor; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Repressor Proteins; Signal Transduction; Transplantation, Heterologous; Wnt Proteins | 2006 |
Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region.
Topics: Aged; Aged, 80 and over; Azacitidine; Basement Membrane; Cell Line, Tumor; Collagen; Collagen Type IV; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Down-Regulation; Drug Combinations; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genes, Reporter; Humans; Laminin; Male; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Proteoglycans; RNA, Messenger | 2006 |
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Cell Line, Tumor; Chromatin; Colorectal Neoplasms; Decitabine; DNA Methylation; Gene Silencing; Genes, Tumor Suppressor; HCT116 Cells; Histones; Humans; Intercellular Signaling Peptides and Proteins; Membrane Proteins; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic | 2006 |
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.
Topics: Azacitidine; Colorectal Neoplasms; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Ovarian Neoplasms; Promoter Regions, Genetic; Tumor Cells, Cultured; Ubiquitin Thiolesterase | 2006 |
Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Melanoma-Specific Antigens; Neoplasm Proteins; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms | 2006 |
High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling array.
Topics: Acetylation; Azacitidine; Binding Sites; Cell Line, Tumor; Colorectal Neoplasms; Computational Biology; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genome, Human; HCT116 Cells; Histones; Homeodomain Proteins; Humans; Microarray Analysis; Oligonucleotide Probes; Sequence Analysis, DNA | 2007 |
Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation.
Topics: Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Comet Assay; DNA Methylation; Folic Acid; Folic Acid Deficiency; Genes, p53; Humans | 2006 |
Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; Dihydrouracil Dehydrogenase (NADP); DNA Methylation; DNA Primers; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Sp1 Transcription Factor; Suppression, Genetic | 2007 |
The synergistic effect of 5-aza-2'-deoxycytidine and 5-fluorouracil on drug-resistant tumors.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Death-Associated Protein Kinases; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Humans; Mice; Mice, Nude; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p14ARF; Up-Regulation; Xenograft Model Antitumor Assays | 2006 |
The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth.
Topics: Azacitidine; Carcinoma; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Humans; Immunohistochemistry; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; Tissue Array Analysis | 2008 |
[The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor].
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenoma; Adult; Aged; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; HCT116 Cells; Humans; Hydroxamic Acids; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer.
Topics: Adenocarcinoma; Azacitidine; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 18; Colorectal Neoplasms; Cyclins; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Loss of Heterozygosity; Mutation; Phosphoproteins; Promoter Regions, Genetic | 2007 |
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines.
Topics: Azacitidine; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Checkpoint Kinase 2; Codon, Nonsense; Colorectal Neoplasms; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm; Female; G1 Phase; Gene Expression Regulation, Neoplastic; Genes, cdc; Genes, p53; Humans; Male; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2009 |
[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor].
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenoma; Adult; Aged; Azacitidine; Biomarkers, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Eye Proteins; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Middle Aged; RNA, Messenger | 2007 |
SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Fluorouracil; HT29 Cells; Humans; Osteonectin; Promoter Regions, Genetic | 2008 |
Expression of MAGE genes in human colorectal carcinoma.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Colorectal Neoplasms; Decitabine; Gene Expression Regulation, Neoplastic; Humans; Melanoma-Specific Antigens; Molecular Sequence Data; Neoplasm Proteins; Tumor Cells, Cultured | 1996 |
Reversal of loss of imprinting in tumor cells by 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Choriocarcinoma; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Muscle Proteins; RNA, Long Noncoding; RNA, Untranslated; Tumor Cells, Cultured | 1997 |
DNA methylation and genetic instability in colorectal cancer cells.
Topics: Azacitidine; Base Sequence; beta-Galactosidase; Cell Line; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Genes, Viral; Humans; Kanamycin Kinase; Molecular Sequence Data; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Protein Biosynthesis; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Retroviridae; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1997 |
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Base Pair Mismatch; Carcinoma; Carrier Proteins; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Mutational Analysis; DNA Repair; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Microsatellite Repeats; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1999 |
Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: the predominant role of hMLH1.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Base Pair Mismatch; Carrier Proteins; Colorectal Neoplasms; DNA Methylation; DNA Repair; DNA Replication; DNA-Binding Proteins; DNA, Neoplasm; Humans; Loss of Heterozygosity; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Proto-Oncogene Proteins; Tumor Cells, Cultured | 1999 |
DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines.
Topics: Azacitidine; Base Pair Mismatch; Colorectal Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Ligases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Repair; Humans; Phenotype; Retroviridae; Tumor Cells, Cultured | 2000 |
Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Northern; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Goblet Cells; Humans; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Mice; Mice, Nude; Models, Genetic; Mucin-2; Mucins; Neoplasm Transplantation; Promoter Regions, Genetic; RNA; Tumor Cells, Cultured | 2001 |
Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Azacitidine; Chi-Square Distribution; Colorectal Neoplasms; Decitabine; Female; Humans; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Lymphatic Metastasis; Male; Membrane Glycoproteins; Methylation; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Proteoglycans; RNA, Messenger; RNA, Neoplasm; Survival Analysis; Syndecan-1; Syndecans; Tumor Cells, Cultured | 2001 |
Methylation in hMLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Azacitidine; Binding Sites; Carrier Proteins; CCAAT-Binding Factor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Humans; Luciferases; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Recombinant Fusion Proteins; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Azacitidine; Carcinogens; Colon; Colorectal Neoplasms; Decitabine; Dimethylhydrazines; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; HT29 Cells; Humans; Injections, Intraperitoneal; Male; Rats; Rats, Inbred F344; Sodium Selenite | 2002 |
Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line.
Topics: Ataxia Telangiectasia Mutated Proteins; Azacitidine; Cell Cycle Proteins; Cell Line; Colorectal Neoplasms; CpG Islands; DNA Methylation; DNA Primers; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Microscopy, Fluorescence; Models, Genetic; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Proteins; Up-Regulation | 2002 |
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Colorectal Neoplasms; Decitabine; DNA Topoisomerases, Type I; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Lethal Dose 50; Methylation; Mice; Mice, Inbred BALB C; Topotecan; Tumor Cells, Cultured | 1992 |
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Survival; Colorectal Neoplasms; Cytarabine; Cytidine Triphosphate; Deoxycytosine Nucleotides; DNA, Neoplasm; Humans; In Vitro Techniques; Tumor Cells, Cultured | 1990 |