azacitidine has been researched along with Cell Transformation, Neoplastic in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (29.53) | 18.7374 |
| 1990's | 20 (13.42) | 18.2507 |
| 2000's | 32 (21.48) | 29.6817 |
| 2010's | 51 (34.23) | 24.3611 |
| 2020's | 2 (1.34) | 2.80 |
| Authors | Studies |
|---|---|
| Audsley, KM; Callus, BA; Finch-Edmondson, ML; Passman, AM; Strauss, RP; van Vuuren, JH; Yeoh, GC | 1 |
| Chhabra, R; Guergues, J; Hill, R; Nadeau, OW; Nanjundan, M; Rockfield, S; Stevens, SM | 1 |
| Allen, B; Masternak, MM; Muller, MT; Pezone, A; Porcellini, A | 1 |
| Bouronikou, E; Diamantopoulos, P; Galanopoulos, AG; Hatzimichael, E; Kontos, CK; Kotsianidis, I; Megalakaki, A; Mparmparousi, D; Panayiotidis, P; Papadaki, H; Papageorgiou, SG; Pappa, V; Poulakidas, E; Symeonidis, A; Vasilatou, D; Vassilakopoulos, TP; Viniou, NA; Zikos, P | 1 |
| Chiu, JF; Huang, N; Li, G; Lin, W; Pei, X; Tao, T | 1 |
| Boasman, K; Graham, C; Rinaldi, CR; Saunthararajah, Y; Simmonds, MJ | 1 |
| Grigoriadis, G; Tedjaseputra, A; Vilcassim, FS | 1 |
| Kang, GH; Park, SY; Shin, SH | 1 |
| Fan, J; Liao, J; Liu, H; Peng, H; Wu, J; Zhao, S | 1 |
| Brown, K; Gillespie, KM; Holly, JM; Jarrett, C; Perks, CM; Zeng, L | 1 |
| Kim, JH; Li, TZ; Shin, SH; Suh, H | 1 |
| Bao, Y; Chen, H; Pan, Y; Shao, C; Ye, S; Yuan, D | 1 |
| Berger, F; Bertoni, F; Cavalli, F; Cogliatti, S; Forconi, F; Gaidano, G; Gattei, V; Kwee, I; Lucioni, M; Marasca, R; Mensah, AA; Orlandi, EM; Rinaldi, A; Rossi, D; Zucca, E | 1 |
| Fujiwara, K; Ghosh, S; Liang, P; Morien, E; Nagase, H; Soma, M | 1 |
| Jiang, R; Li, Y; Liu, Q; Luo, F; Wang, B; Xu, W; Xu, Y; Zhang, A; Zhao, Y | 1 |
| Schleiffenbaum, BE | 1 |
| Abba, MC; Cattaneo, ER; Coleman, RA; Garcia-Fabiani, MB; Gonzalez-Baro, MR; Lacunza, E; Montanaro, MA; Pellon-Maison, M; Quiroga, IY; Soler-Gerino, MC | 1 |
| Li, HM; Zhang, R | 1 |
| Bak, YT; Choe, J; Joo, MK; Kim, HJ; Kim, JS; Kim, KH; Lee, BJ; Park, JJ; Yoo, HS | 1 |
| Bhatt, VR | 1 |
| Amoozgar, Z; Goldberg, MS; Huang, J; Orsulic, S; Saleh, MH; Wang, L; Xing, D | 1 |
| An, Y; Deng, H; Gao, F; Li, C; Ma, Y; Tong, J; Wang, D; Wang, X; Xu, X; Yamanaka, K; Yang, X; Zhao, Y; Zhu, Z | 1 |
| Li, X; Liao, J; Liu, R; Pan, E; Pu, Y; Wang, Y; Yang, M; Yin, L | 1 |
| Bintz, J; Garcia, MN; Grasso, D; Iovanna, JL; Lomberk, G; Loncle, C; Lopez, MB; Molejon, MI; Urrutia, R | 1 |
| Gasque Schoof, CR; Izzotti, A; Jasiulionis, MG; Vasques, Ldos R | 1 |
| Moolmuang, B; Ruchirawat, M; Singhirunnusorn, P | 1 |
| Atagunduz, IK; Avsar, E; Deveci, B; Ferhanoglu, B; Geduk, A; Kara, O; Kurtoglu, E; Mehtap, O; Ozturk, E; Salim, O; Tiftik, EN; Tombak, A; Toptas, T; Tuglular, TF; Undar, L; Yucel, OK | 1 |
| Chen, Y; Du, Q; Huang, Y; She, F; Wu, W | 1 |
| Baba, H; Baba, Y; Harada, K; Ishimoto, T; Iwatsuki, M; Kiyozumi, Y; Kosumi, K; Kurashige, J; Miyake, K; Nakamura, K; Nakao, M; Ohuchi, M; Sakamoto, Y; Shigaki, H; Watanabe, M; Yoshida, N | 1 |
| Mahalingaiah, PK; Ponnusamy, L; Singh, KP | 1 |
| Bensaddek, D; Endo, A; Lamond, AI; Ly, T; Nicolas, A; Pippa, R | 1 |
| Chang, CK; Guo, J; He, Q; Li, X; Song, LX; Su, JY; Wu, D; Wu, LY; Xiao, C; Xu, F; Zhang, Z; Zhao, YS | 1 |
| Chen, H; El-Rifai, W; Peng, DF; Razvi, M; Roessner, A; Schneider-Stock, R; Washington, K | 1 |
| Datta, J; Ghoshal, K; Jacob, ST; Kutay, H; Lucas, DM; Majumder, S; Motiwala, T; Roy, S | 1 |
| Issa, JP | 2 |
| Hu, YC; Huo, YY; Niu, LJ; Pan, XJ; Sun, XJ; Wu, DC; Yang, ZH; Zhong, KJ; Zhou, PK; Zhu, MX | 1 |
| Gao, A; Guo, W; Niu, P; Song, S; Tian, L; Zuo, X | 1 |
| Manna, S; Mukherjee, P; Mukherjee, S; Pal, D; Panda, CK | 1 |
| Egan, LJ; Foran, E; Garrity-Park, MM; Limburg, PJ; Mureau, C; Newell, J; Smyrk, TC | 1 |
| Fujimoto, J; Hong, WK; Kong, M; Lee, JJ; Lotan, R | 1 |
| Belden, SE; Borger, DR; Curley, MD; Foster, R; Friel, AM; Mohapatra, G; Rueda, BR; Sergent, PA; Therrien, VA; Zhang, L; Zukerberg, LR | 1 |
| Ao, L; Cao, J; Cui, ZH; Liu, JY; Liu, WB; Xiang, YL; Yuan, XY; Zhou, YH; Zhou, ZY | 1 |
| Gronemeyer, H; Hahn, WC; Kedinger, V; Khanwalkar, H; Kotova, I; Lund, P; Voltz, E | 1 |
| Lei, YX; Wang, CX; Zhou, ZH | 1 |
| Carducci, MA; Herman, JG; Shabbeer, S; Simons, BW; Williams, SA | 1 |
| Ahuja, N; Baylin, SB; Beaty, R; Brock, MV; Cai, Y; Feller-Kopman, D; Harbom, KM; Harris, J; Issa, JP; Jang, YY; Li, H; Lin, YC; Matsui, W; Minn, I; Pappou, E; Rassool, FV; Robert, C; Sharkis, SJ; Shin, JJ; Stearns, V; Tsai, HC; Van Neste, L; Welm, AL; Yarmus, LB; Yen, RW; Zahnow, CA | 1 |
| Chang, C; He, Q; Li, X; Wu, L; Xu, F; Zhang, Y; Zhang, Z | 1 |
| Chen, L; Jing, N; Song, W; Wang, J; Wu, J; Yang, Y; Zhang, X | 1 |
| Aransay, AM; Aspichueta, P; Beraza, N; Calvisi, DF; Evert, M; Fernández-Ramos, D; García-Rodríguez, JL; Gutiérrez, V; Lozano, JJ; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-López, N; Mato, JM; Schlangen, K; Varela-Rey, M; Wagner, C | 1 |
| Chan, SH; Chen, H; Cheung, FM; Chiu, PM; Chua, D; Hyytiainen, M; Kan, R; Keski-Oja, J; Ko, JM; Kwong, DL; Lee, AW; Lung, ML; Nicholls, JM; Stanbridge, EJ; Tao, Q; Tsao, SW; Wong, VC; Zabarovsky, ER | 1 |
| Calonne, E; Delbecque, K; Delvenne, P; Deplus, R; Ennaji, MM; Fuks, F; Guenin, S; Kridelka, F; Krusy, N; Lampe, X; Mouallif, M | 1 |
| Colizzi, F; Coral, S; Covre, A; Dalla Santa, S; Fonsatti, E; Fratta, E; Maio, M; Nicolay, HJ; Parisi, G; Rizzo, A; Sigalotti, L | 1 |
| Castro, CC; Germano, RT; Magalhaes, SM; Pinheiro, RF; Sousa, JC | 1 |
| Godwin, AK; Guo, S; Liu, M | 1 |
| Chang, C; Huang, CK; Lee, SO; Li, L; Liang, L; Luo, J; Niu, Y; Tian, J | 1 |
| Atenafu, EG; Brandwein, JM; Craddock, KJ; Gupta, V; Kennedy, JA; Lipton, JH; Messner, HA; Minden, MD; Schimmer, AD; Schuh, AC; Yee, KW | 1 |
| Brown, J; Felix, DH; Fleming, J; Harrison, PR; MacDonald, DG; McGregor, F; Muntoni, A; Parkinson, EK | 1 |
| Alder, H; Croce, CM; Kaiser, LR; Kuroki, T; Matsuyama, A; Trapasso, F; Williams, NN; Yendamuri, S | 1 |
| Longo, M; Nelson, PS; Schuster, JM | 1 |
| Berx, G; Cirnes, L; Correia da Rocha, AS; Debruyne, PR; Li, X; Mareel, MM; Pocard, M; Poupon, MF; van Roy, FM; Vermeulen, SJ | 1 |
| Alder, H; Aqeilan, RI; Cesari, R; Croce, CM; Kanematsu, T; Kuroki, T; Matsuyama, A; Mori, M; Nolli, ML; Rattan, S; Trapasso, F; Williams, NN; Yendamuri, S | 1 |
| Guo, XN; Qiao, SK; Xu, SR | 1 |
| Fujisawa, T; Gazdar, AF; Iizasa, T; Sathyanarayana, UG; Shigematsu, H; Shivapurkar, N; Suzuki, M; Takahashi, T | 1 |
| Der, CJ; Frantz, K; Muniz-Medina, VM; Pruitt, K; Rangnekar, VM; Rojas, RJ; Shields, JM; Ulkü, AS | 1 |
| Awwad, RT; Bisht, KS; Bradbury, CM; Gius, D; Ho, AS; Huang, L; Nguyen, P; Smart, DD; Sun, L | 1 |
| Gozzini, A; Santini, V | 1 |
| Cheng, X; Liu, J; Mei, FC; Young, TW | 1 |
| Contente, S; Friedman, RM; Yeh, TJ | 1 |
| Byrd, JC; Chen, SS; Liu, TH; Matkovic, JJ; Plass, C; Raval, A | 1 |
| Aguilera, O; Ballestar, E; Espada, J; Esteller, M; Fraga, MF; García, JM; González-Sancho, JM; Herranz, M; Muñoz, A; Paz, MF | 1 |
| Benbrahim-Tallaa, L; Boos, J; Liu, J; Qian, X; Qu, W; Waalkes, MP; Xie, Y; Yu, L | 1 |
| Carvalho, AL; Cerveira, N; Costa, VL; Henrique, R; Hoque, MO; Jerónimo, C; Oliveira, J; Ribeiro, FR; Sidransky, D; Teixeira, MR | 1 |
| Coleman, WB; Jones, WD; Rivenbark, AG | 1 |
| Nguyen, DM; Schrump, DS | 1 |
| Hanada, N; Sekiguchi, N; Shimizu, N; Utani, K | 1 |
| Fridman, AL; Li, Q; Rosati, R; Tainsky, MA | 1 |
| Eblin, KE; Futscher, BW; Gandolfi, AJ; Jensen, TJ; Novak, P | 1 |
| Chen, ZC; Liang, T; Tan, T; Xiao, YH; Xiao, ZQ; Yi, H | 1 |
| Jones, PA; Landolph, JR | 1 |
| Jones, PA; Taylor, SM | 2 |
| Dina, D; Gattoni-Celli, S; Kirschmeier, P; Weinstein, IB | 1 |
| Hall, EJ; Miller, RC; Osmak, R; Zimmerman, M | 1 |
| Jones, PA; Riggs, AD | 1 |
| Gattoni-Celli, S; Horowitz, A; Hsiao, W; Jeffrey, A; Kirschmeier, P; Weinstein, IB | 1 |
| Donaghue, TP; Frost, P; Kerbel, RS; Liteplo, RG | 1 |
| Basilico, C; Liboi, E | 1 |
| Hoffman, RM | 1 |
| Chiswell, DJ; Gillespie, DA; Searle, S; Wyke, JA | 1 |
| Gadi, IK; Harrison, JJ; Sager, R | 1 |
| Ranney, DF; Shay, JW; Walker, C | 1 |
| Gevers, W; Parker, MI | 1 |
| Bouck, N; Kokkinakis, D; Ostrowsky, J | 1 |
| Furusako, S; Kawashima, K; Mori, M; Namba, M; Usuki, H | 1 |
| Blann, E; Hammons, GJ; Lyn-Cook, BD; Nichols, J; Warren, GJ | 1 |
| Barrett, JC; West, RW | 1 |
| Almeida, A; Dutrillaux, B; Jeanpierre, M; Kokalj-Vokac, N; Malfoy, B; Viegas-Péquignot, E | 1 |
| Fan, H; Hsiao, WL; Kothari, NH; Mendosa, G | 1 |
| Culp, LA; Kogerman, P; Sy, MS | 1 |
| Prasanna, P; Samid, D; Shack, S; Wilson, VL | 1 |
| Dritschilo, A; Prasad, SC; Soldatenkov, VA; Thraves, PJ; Varghese, S | 1 |
| Fenaux, P; Quesnel, B | 1 |
| Chan, TA; Evron, E; Ferguson, AT; Futreal, PA; Hermeking, H; Lambers, AR; Marks, JR; Pandita, TK; Stampfer, MR; Sukumar, S; Umbricht, CB | 1 |
| Sasaki, MS; Yang, L | 1 |
| Huschtscha, LI; Neumann, AA; Noble, JR; Reddel, RR | 1 |
| Feng, G; Lotan, R; Xu, X; Youssef, EM | 1 |
| Marx, J | 1 |
| Corsaro, M; Di Croce, L; Fanelli, M; Faretta, M; Fazi, F; Fuks, F; Kouzarides, T; Lo Coco, F; Minucci, S; Nervi, C; Pelicci, PG; Raker, VA | 1 |
| Altanerová, V | 2 |
| Aaronson, SA; Bensinger, WI; Greenberger, JS | 1 |
| Bystrická, M; Csabayová, M; Golais, F; Lesko, J; Sabó, A | 1 |
| Samid, D; Shack, S; Sherman, LT | 1 |
| Parker, RF; Scott, RE; Wang, H; Witte, MM | 1 |
| Pechan, R; Schiffmann, D; Stopper, H | 1 |
| Fleurent, J; Hamel, M; Sircar, S; Weber, JM | 1 |
| Curren, RA; Kouri, RE; Lubet, RA; Putman, DL; Schechtman, LM | 1 |
| Azumi, N; Benfield, JR; Gabriel, A; Hammond, WG; Hill, LR; Paladugu, RR; Yellin, A | 1 |
| Bassin, RH; Rimoldi, D; Samid, D; Srikantan, V; Wilson, VL | 1 |
| Hustad, CM; Jones, PA | 1 |
| Pfizenmaier, K; Schäfer, R; Seliger, B | 1 |
| Gray, MD; Jesch, SA; Stein, GH | 1 |
| Gattoni-Celli, S; Hsiao, WL; Weinstein, IB | 2 |
| Suk, WA | 1 |
| Jones, PA | 1 |
| Harrison, JJ; Sager, R | 1 |
| Nettesheim, P; Walker, C | 2 |
| Collins, JL; Lin, Y; Patek, PQ | 1 |
| Friedman, RM | 1 |
| Bongarzone, I; Borrello, MG; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA | 1 |
| Flessate, DM; Friedman, RM; Samid, D | 1 |
| Kuratomi, Y; Kuwano, M; Masumi, S; Ono, M; Yasutake, C | 1 |
| Biedler, JL; Melera, PW; Michitsch, RW | 1 |
| Feinberg, AP; Rainier, S | 1 |
| Collins, JL; Vanderslice, WE | 1 |
| Gonzales, F; Harrington, MA; Jones, PA | 1 |
| Bongarzone, I; Borrello, MG; Cattadori, MR; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA; Traversari, C | 1 |
| Szpirer, C; Vanhamme, L | 1 |
| Grant, SG; Worton, RG | 1 |
| Avvedimento, EV; Gallo, A; Gottesman, ME; Musti, A; Obici, S; Sanchez, M | 1 |
| Cecchini, E; Citti, L; Durante, M; Geri, C; Natali, L; Nuti Ronchi, V; Parenti, R | 1 |
| Durr, FE; Lindh, D; Wallace, RE | 1 |
| Aaronson, SA; Scolnick, EM; Stephenson, JR | 1 |
| Altaner, C; Altanerová, V | 1 |
| Wyke, JA | 1 |
| Linial, M; Mason, WS | 1 |
8 review(s) available for azacitidine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
[Research progress of epigenetic drug decitabine in AML].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Humans; Leukemia, Myeloid, Acute | 2014 |
Epigenetic changes in the myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia, Myeloid; Methylation; Myelodysplastic Syndromes; Neoplasms; Protein Processing, Post-Translational | 2010 |
The epigenome as a molecular marker and target.
Topics: Azacitidine; Biomarkers, Tumor; Cell Cycle; Cell Transformation, Neoplastic; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Protein Processing, Post-Translational | 2005 |
Targeting the epigenome for the treatment of thoracic malignancies.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Chromatin; Decitabine; Depsipeptides; Drug Evaluation, Preclinical; Epigenesis, Genetic; Humans; Lung Neoplasms | 2006 |
5-methylcytosine, gene regulation, and cancer.
Topics: 5-Methylcytosine; Animals; Azacitidine; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; Fibroblasts; Gene Expression Regulation; Humans; Models, Biological; Muscles; Neoplasms; Oncogenes | 1983 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
P15INK4b gene methylation and myelodysplastic syndromes.
Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 9; Clinical Trials, Phase II as Topic; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Decitabine; Disease Progression; DNA Methylation; Genes, p16; Genes, Tumor Suppressor; Hematopoiesis; Humans; Leukemia, Myeloid; Mice; Myelodysplastic Syndromes; Neoplasm Proteins; Precancerous Conditions; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transforming Growth Factor beta; Tumor Suppressor Proteins | 1999 |
Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromosomes; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Genes, Viral; Humans; Methylation; Phenotype; Species Specificity | 1985 |
141 other study(ies) available for azacitidine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Loss of ARF/INK4A Promotes Liver Progenitor Cell Transformation Toward Tumorigenicity Supporting Their Role in Hepatocarcinogenesis.
Topics: Animals; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; CRISPR-Cas Systems; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; Epithelial-Mesenchymal Transition; Gene Deletion; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Genes, p16; Liver; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phenotype; Snail Family Transcription Factors; Stem Cells; Tumor Stem Cell Assay; Vimentin | 2020 |
Global miRNA/proteomic analyses identify miRNAs at 14q32 and 3p21, which contribute to features of chronic iron-exposed fallopian tube epithelial cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Transformed; Cell Transformation, Neoplastic; Down-Regulation; Epithelial Cells; Fallopian Tubes; Female; Ferric Compounds; Gene Expression Profiling; Genetic Loci; Humans; MDS1 and EVI1 Complex Locus Protein; MicroRNAs; Ovarian Neoplasms; Proteome; Proteomics; Quaternary Ammonium Compounds; Transcriptome; Transfection; Vorinostat | 2021 |
Non-homologous end joining induced alterations in DNA methylation: A source of permanent epigenetic change.
Topics: Alleles; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Methylation; Doxycycline; Epigenesis, Genetic; Green Fluorescent Proteins; HeLa Cells; Humans; Neoplasms | 2017 |
The prognostic value of monosomal karyotype (MK) in higher-risk patients with myelodysplastic syndromes treated with 5-Azacitidine: A retrospective analysis of the Hellenic (Greek) Myelodysplastic syndromes Study Group.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Transformation, Neoplastic; Female; Greece; Humans; Karyotype; Leukemia, Myeloid, Acute; Male; Middle Aged; Monosomy; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Survival Analysis; Treatment Outcome | 2018 |
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells.
Topics: Animals; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Lung; NAD(P)H Dehydrogenase (Quinone); Oxides; Promoter Regions, Genetic; Rats | 2018 |
Using PU.1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers; Biomarkers, Tumor; Bone Marrow; Cell Transformation, Neoplastic; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Prognosis; Proto-Oncogene Proteins; Repressor Proteins; Trans-Activators; Up-Regulation | 2019 |
Ocular infiltration as initial presentation of acute monocytic leukaemia transformed from chronic myelomonocytic leukaemia associated with
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Exophthalmos; Fatal Outcome; Humans; Leukemia, Monocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemic Infiltration; Male; Mutation; Proto-Oncogene Proteins B-raf; Retina; Retinal Diseases | 2019 |
Down-regulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis.
Topics: Azacitidine; Cell Movement; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Down-Regulation; Dual-Specificity Phosphatases; Epigenesis, Genetic; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase Cell Cycle Checkpoints; Gastric Mucosa; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Humans; Male; Middle Aged; Multivariate Analysis; Phosphorylation; Prognosis; Promoter Regions, Genetic; Reproducibility of Results; Stomach Neoplasms | 2013 |
Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomas.
Topics: Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Growth Hormone-Secreting Pituitary Adenoma; Humans; Mice; Monomeric GTP-Binding Proteins; Promoter Regions, Genetic; Rats; RNA, Messenger; Tumor Suppressor Protein p53 | 2013 |
Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Insulin-Like Growth Factor Binding Protein 3; MCF-7 Cells; RNA, Small Interfering; Transcription Factor AP-2; Tumor Suppressor Protein p53 | 2013 |
Influence of in vitro biomimicked stem cell 'niche' for regulation of proliferation and differentiation of human bone marrow-derived mesenchymal stem cells to myocardial phenotypes: serum starvation without aid of chemical agents and prevention of spontan
Topics: Adult; Azacitidine; Biomimetic Materials; Cell Cycle; Cell Differentiation; Cell Proliferation; Cell Separation; Cell Shape; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Child; Culture Media, Serum-Free; Dimethyl Sulfoxide; Extracellular Matrix; Female; Flow Cytometry; Humans; Immunohistochemistry; Male; Mesenchymal Stem Cells; Myocardium; Organogenesis; Phenotype; Real-Time Polymerase Chain Reaction; Stem Cell Niche | 2016 |
Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; B-Lymphocytes; Cadmium; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Granulocyte-Macrophage Progenitor Cells; Humans; Rats; RNA, Messenger; Time Factors | 2013 |
Promoter methylation patterns in Richter syndrome affect stem-cell maintenance and cell cycle regulation and differ from de novo diffuse large B-cell lymphoma.
Topics: Azacitidine; Cell Cycle; Cell Transformation, Neoplastic; Cluster Analysis; Decitabine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Neoplastic Stem Cells; Oncostatin M; Promoter Regions, Genetic; Reproducibility of Results | 2013 |
Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Papilloma; Promoter Regions, Genetic; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-2 | 2015 |
The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-κB.
Topics: Animals; Arsenites; Azacitidine; Cell Line; Cell Transformation, Neoplastic; Decitabine; Epigenesis, Genetic; Gene Silencing; Humans; Keratinocytes; Mice; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; NF-kappa B; ras Proteins; Sodium Compounds | 2014 |
[CME myelodysplasia - a frequent hematologic neoplasia in the elderly].
Topics: Aged, 80 and over; Anemia, Aplastic; Azacitidine; Bone Marrow; Bone Marrow Examination; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; Diagnosis, Differential; Disease Progression; Hematopoiesis; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Prognosis; Thalidomide | 2014 |
Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
Topics: Animals; Azacitidine; Breast Neoplasms; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Computer Simulation; Decitabine; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Glycerol-3-Phosphate O-Acyltransferase; Humans; Male; Mice; RNA, Small Interfering; Testis | 2014 |
CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis.
Topics: Azacitidine; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; Gene Expression; Gene Silencing; Humans; Neoplasm Staging; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Suppressor Proteins | 2015 |
Leukemic transformation in essential thrombocythemia.
Topics: Azacitidine; Cell Transformation, Neoplastic; Humans; Janus Kinase 2; Leukemia, Myeloid, Acute; Mutation; Prognosis; Risk Factors; Stem Cell Transplantation; Thrombocythemia, Essential; Transplantation, Homologous | 2014 |
Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; Azacitidine; CD8-Positive T-Lymphocytes; Cell Movement; Cell Transformation, Neoplastic; CTLA-4 Antigen; Cytokines; Decitabine; Female; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Killer Cells, Natural; Lymph Nodes; Lymphocytes, Tumor-Infiltrating; Mice; Ovarian Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation.
Topics: Antioxidants; Arsenites; Azacitidine; Blotting, Western; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Keratinocytes; NF-E2-Related Factor 2; Promoter Regions, Genetic; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Teratogens | 2015 |
Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1.
Topics: 3' Untranslated Regions; Azacitidine; Base Sequence; Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Epigenetic Repression; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Order; Genetic Loci; Humans; MicroRNAs; Nerve Tissue Proteins; Receptors, Immunologic; RNA Interference; RNA, Messenger; Roundabout Proteins | 2015 |
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; Cellular Senescence; CpG Islands; DNA Methylation; DNA-Binding Proteins; Dynamin I; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung Neoplasms; Mice; Mice, Knockout; Neoplasm Proteins; Oncogenes; Pancreatic Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras) | 2015 |
The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Silencing; Melanocytes; Melanoma; Mice; MicroRNAs; Promoter Regions, Genetic | 2015 |
Effects of 5-Aza-2'-Deoxycytidine, Bromodeoxyuridine, Interferons and Hydrogen Peroxide on Cellular Senescence in Cholangiocarcinoma Cells.
Topics: Azacitidine; Bile Duct Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Cholangiocarcinoma; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA Damage; Humans; Hydrogen Peroxide; Interferons; Signal Transduction; Tumor Suppressor Protein p53 | 2016 |
Azacitidine versus decitabine in patients with refractory anemia with excess blast-Results of multicenter study.
Topics: Aged; Anemia, Refractory, with Excess of Blasts; Antimetabolites, Antineoplastic; Azacitidine; Blood Component Transfusion; Cell Transformation, Neoplastic; Decitabine; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Patient Selection; Propensity Score; Remission Induction; Retrospective Studies; Survival Rate | 2016 |
Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; Disease Models, Animal; DNA Methylation; Female; Gallbladder Neoplasms; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Mice; Middle Aged; Promoter Regions, Genetic; Repressor Proteins | 2016 |
UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma.
Topics: Aged; Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; CCAAT-Enhancer-Binding Proteins; Cell Transformation, Neoplastic; Disease-Free Survival; DNA Methylation; Epigenesis, Genetic; Epigenomics; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagus; Female; Humans; Long Interspersed Nucleotide Elements; Male; Middle Aged; Prognosis; Proportional Hazards Models; Sequence Analysis, DNA; Treatment Outcome; Ubiquitin; Ubiquitin-Protein Ligases | 2016 |
Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells.
Topics: Acetylation; Animals; Azacitidine; Blotting, Western; Cell Line; Cell Transformation, Neoplastic; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydrogen Peroxide; Kidney; Kidney Neoplasms; Mice, Nude; Oxidants; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous | 2017 |
The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Cell Movement; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin Assembly and Disassembly; Epithelial Cells; Female; Humans; Mass Spectrometry; Neoplasm Invasiveness; Oncogene Protein pp60(v-src); Protein Subunits; Proteomics; Signal Transduction; Transcription Factors | 2017 |
TP53 mutations predict decitabine-induced complete responses in patients with myelodysplastic syndromes.
Topics: Azacitidine; Cell Transformation, Neoplastic; Chromosome Aberrations; Decitabine; Humans; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Predictive Value of Tests; Recurrence; Remission Induction; Survival Analysis; Treatment Outcome; Tumor Suppressor Protein p53 | 2017 |
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Barrett Esophagus; Cell Transformation, Neoplastic; CpG Islands; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Down-Regulation; Epigenesis, Genetic; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Transferase; Humans; Hydroxamic Acids; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2009 |
PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Azacitidine; Cell Transformation, Neoplastic; CpG Islands; DNA Methylation; DNA Modification Methylases; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Interphase; Isoenzymes; K562 Cells; Leukemia, Myeloid; Mice; Nuclear Proteins; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 3; STAT5 Transcription Factor | 2009 |
Cancer prevention: epigenetics steps up to the plate.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Chemoprevention; Cytidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Models, Biological; Neoplasms | 2008 |
Alteration of transcriptional profile in human bronchial epithelial cells induced by cigarette smoke condensate.
Topics: Animals; Azacitidine; Blotting, Northern; Bronchi; Cell Differentiation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Decitabine; Epithelial Cells; Flow Cytometry; Gene Expression Profiling; Humans; Mice; Nicotiana; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2009 |
Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells.
Topics: Animals; Azacitidine; Bronchial Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Decitabine; Enzyme Activation; Epigenesis, Genetic; Epithelial Cells; Female; Humans; Male; Mice; Mice, Inbred BALB C; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Silicon Dioxide; Transcriptional Activation | 2010 |
Sequential loss of cell cycle checkpoint control contributes to malignant transformation of murine embryonic fibroblasts induced by 20-methylcholanthrene.
Topics: Aneuploidy; Animals; Antimetabolites; Azacitidine; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Chromosome Aberrations; Decitabine; DNA Damage; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Gene Expression Regulation, Neoplastic; Genotype; Gestational Age; Methylcholanthrene; Mice; Phenotype; Phosphorylation; Signal Transduction | 2010 |
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Topics: Azacitidine; Carcinogenicity Tests; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Inflammation Mediators; Interleukin-6; Neoplasm Metastasis; Promoter Regions, Genetic; Up-Regulation | 2010 |
Validation of a novel statistical model for assessing the synergy of combined-agent cancer chemoprevention.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Decitabine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Models, Statistical; Neoplasms; Vorinostat | 2010 |
Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells.
Topics: AC133 Antigen; Animals; Antigens, CD; Azacitidine; Cell Transformation, Neoplastic; Decitabine; Endometrial Neoplasms; Epigenomics; Female; Glycoproteins; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Peptides | 2010 |
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Topics: Animals; Azacitidine; Cadherins; Cell Adhesion; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Decitabine; Diethylnitrosamine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Enzyme Inhibitors; Female; Gene Silencing; Immunoglobulins; Lung Neoplasms; Male; Methylcholanthrene; Rats; Rats, Wistar; Tissue Inhibitor of Metalloproteinase-3; Up-Regulation | 2011 |
Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; HeLa Cells; Humans; Interferons; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Proto-Oncogene Proteins p21(ras); Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2011 |
Analysis of aberrant methylation in DNA repair genes during malignant transformation of human bronchial epithelial cells induced by cadmium.
Topics: Animals; Azacitidine; Blotting, Western; Bronchi; Cadmium Chloride; Carcinogens; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Time Factors | 2012 |
Progression of prostate carcinogenesis and dietary methyl donors: temporal dependence.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Choline; Decitabine; Diet; Disease Progression; DNA Methylation; Folic Acid; Homocysteine; Humans; Male; Methionine; Mice; Mice, Nude; Prostatic Neoplasms; Tumor Cells, Cultured; Vitamin B 6 | 2012 |
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Bone Marrow Cells; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Damage; DNA Methylation; DNA Modification Methylases; Gene Silencing; Humans; Leukemia; Mice; Molecular Sequence Data; Neoplastic Stem Cells; Promoter Regions, Genetic; Signal Transduction; Tumor Cells, Cultured | 2012 |
Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Transformation, Neoplastic; Cytarabine; Decitabine; Female; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Harringtonines; Homoharringtonine; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Predictive Value of Tests; Prognosis; Ribosomal Proteins; Risk Factors; Treatment Outcome; Young Adult | 2012 |
Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.
Topics: Animals; Azacitidine; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cisplatin; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Regulatory Networks; Mice; Protein Interaction Maps; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cyclic AMP-Dependent Protein Kinases; DNA Methylation; Enzyme Activation; Enzyme Inhibitors; Glycine N-Methyltransferase; Guanine Nucleotide Exchange Factors; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; ras Guanine Nucleotide Exchange Factors; ras Proteins; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Signal Transduction; Time Factors; Transfection; Tumor Burden | 2012 |
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma.
Topics: Azacitidine; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Latent TGF-beta Binding Proteins; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neovascularization, Pathologic; Promoter Regions, Genetic; Tumor Microenvironment; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2012 |
Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis.
Topics: Azacitidine; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cervix Uteri; Cluster Analysis; Cytological Techniques; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Neoplasms, Glandular and Epithelial; Neoplastic Stem Cells; Nuclear Proteins; Octamer Transcription Factor-3; Ovarian Neoplasms; Promoter Regions, Genetic; Sequence Analysis, DNA; SOXB1 Transcription Factors; Trans-Activators; Uterine Cervical Neoplasms | 2012 |
Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: immunotherapeutic implications.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Immunotherapy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Promoter Regions, Genetic; Receptors, G-Protein-Coupled; Signal Transduction | 2012 |
Case report of isochromosome 17q in acute myeloid leukemia with myelodysplasia-related changes after treatment with a hypomethylating agent.
Topics: Azacitidine; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 17; Decitabine; DNA Methylation; Fatal Outcome; Humans; Isochromosomes; Karyotyping; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes | 2012 |
Transcriptional regulation of hTREX84 in human cancer cells.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA-Binding Proteins; Exons; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Nuclear Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; RNA-Binding Proteins; Sequence Analysis, DNA; Sulfites; Transcription Factor RelA; Transcription, Genetic | 2012 |
Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Transplantation, Heterologous | 2012 |
Treatment outcomes following leukemic transformation in Philadelphia-negative myeloproliferative neoplasms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Combined Modality Therapy; Cytarabine; Decitabine; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Myeloproliferative Disorders; Philadelphia Chromosome; Registries; Survival Analysis; Transplantation, Homologous; Treatment Outcome; Young Adult | 2013 |
Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Disease Progression; DNA-Binding Proteins; ErbB Receptors; Humans; Mouth Mucosa; Mouth Neoplasms; Polo-Like Kinase 1; Precancerous Conditions; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptors, Retinoic Acid; RNA, Messenger; Telomerase; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2002 |
Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer.
Topics: Aged; Aged, 80 and over; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 3; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Membrane Glycoproteins; Middle Aged; Neoplasm Proteins; Promoter Regions, Genetic; Semaphorins; Tumor Cells, Cultured | 2003 |
Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Glioma; Humans; Male; Membrane Glycoproteins; Methyltransferases; Neoplasm Invasiveness; Neoplasms; Oligonucleotide Array Sequence Analysis; Serine Proteinase Inhibitors; Trypsin Inhibitor, Kunitz Soybean; Tumor Cells, Cultured | 2003 |
Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells.
Topics: Azacitidine; Cell Aggregation; Cell Culture Techniques; Cell Movement; Cell Transformation, Neoplastic; Colonic Neoplasms; Decitabine; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Intestinal Mucosa; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
Topics: Adenocarcinoma; Alleles; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Separation; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; DNA Mutational Analysis; DNA, Complementary; Exons; Flow Cytometry; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Oxidoreductases; Pancreatic Neoplasms; Promoter Regions, Genetic; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2004 |
[Growth and gene expression of leukemia cell after treated with methylation inhibitor 5-aza-2'-deoxycytidine].
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; HL-60 Cells; Humans; K562 Cells; RNA, Messenger; Tumor Suppressor Proteins | 2004 |
Aberrant methylation of Reprimo in lung cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Cycle; Cell Cycle Proteins; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Genes, p53; Glycoproteins; Humans; Lung Neoplasms; Lymphocytes; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2005 |
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
Topics: Agar; Alleles; Animals; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Blotting, Northern; Blotting, Western; Butadienes; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Female; Fibroblasts; Flavonoids; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; NIH 3T3 Cells; Nitriles; Ovary; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; raf Kinases; Rats; RNA; RNA, Messenger; Signal Transduction; Up-Regulation | 2005 |
Butyrates and decitabine cooperate to induce histone acetylation and granulocytic maturation of t(8;21) acute myeloid leukemia blasts.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Modification Methylases; Epigenesis, Genetic; Gene Silencing; Granulocytes; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid, Acute; Mannose; Translocation, Genetic | 2005 |
RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.
Topics: Azacitidine; Cell Adhesion Molecules; Cell Line, Transformed; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Epithelial Cells; Female; Gene Silencing; Genes, ras; GPI-Linked Proteins; Humans; Ovarian Neoplasms; Ovary; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Signal Transduction | 2006 |
Transformation of revertant murine cells by 5-azacytidine results in rapid inhibition of lysyl oxidase expression.
Topics: Animals; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Genes, ras; Mice; NIH 3T3 Cells; Protein-Lysine 6-Oxidase; Time Factors | 2005 |
CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia.
Topics: Azacitidine; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Silencing; Humans; Intercellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Proteins; Proto-Oncogene Proteins; Signal Transduction; Wnt Proteins | 2006 |
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Adenomatous Polyposis Coli Protein; Animals; Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Epithelium; Genes, Tumor Suppressor; Humans; Intercellular Signaling Peptides and Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Repressor Proteins; Signal Transduction; Transplantation, Heterologous; Wnt Proteins | 2006 |
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Topics: Animals; Arsenic; Arsenites; Azacitidine; Blotting, Western; Carcinogens; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Dealkylation; Decitabine; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Growth; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological | 2006 |
Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer.
Topics: Adenocarcinoma; Adult; Aged; Azacitidine; Cell Line, Tumor; Cell Transformation, Neoplastic; Cyclin D2; Cyclins; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2006 |
DNA methylation-dependent silencing of CST6 in human breast cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; Cystatin M; Cystatins; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Promoter Regions, Genetic | 2006 |
Interconversion of intra- and extra-chromosomal sites of gene amplification by modulation of gene expression and DNA methylation.
Topics: Acetylation; Animals; Anti-Bacterial Agents; Azacitidine; Butyrates; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomes, Mammalian; Cricetinae; Cricetulus; DNA Methylation; Doxycycline; Gene Amplification; Gene Expression; Gene Silencing; Histones; Humans; In Situ Hybridization, Fluorescence; Insulator Elements; Matrix Attachment Regions; Plasmids; Replication Origin; Tandem Repeat Sequences; Transcriptional Activation | 2007 |
Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization.
Topics: Azacitidine; Blotting, Western; Cell Division; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; Cluster Analysis; Decitabine; Epigenesis, Genetic; Gene Expression; Gene Expression Profiling; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Proteins; Interferon-alpha; Li-Fraumeni Syndrome; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Epigenetic remodeling during arsenical-induced malignant transformation.
Topics: Acetylation; Arsenicals; Azacitidine; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; Environmental Exposure; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Teratogens; Urinary Bladder Neoplasms; Urothelium | 2008 |
[Analysis of in vitro anti-leukemia effect of 5-aza-2'-deoxycitydine].
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Calgranulin A; Calgranulin B; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; HL-60 Cells; Humans; RNA, Messenger | 2008 |
Mutagenicity of 5-azacytidine and related nucleosides in C3H/10T 1/2 clone 8 and V79 cells.
Topics: Animals; Azacitidine; Azaguanine; Cell Differentiation; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; Cricetulus; Drug Resistance; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutation; Ouabain | 1982 |
Changes in phenotypic expression in embryonic and adult cells treated with 5-azacytidine.
Topics: Adipose Tissue; Animals; Azacitidine; Cartilage; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Embryo, Mammalian; Interphase; Male; Mice; Muscles; Prostate; RNA | 1982 |
Carcinogen- and radiation-transformed C3H 10T1/2 cells contain RNAs homologous to the long terminal repeat sequence of a murine leukemia virus.
Topics: Animals; Azacitidine; Base Sequence; Bromodeoxyuridine; Cell Transformation, Neoplastic; DNA, Neoplasm; Mice; Moloney murine leukemia virus; Nucleic Acid Hybridization; RNA, Messenger; RNA, Neoplasm; RNA, Viral | 1982 |
Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Doxorubicin; Fibroblasts; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation, Ionizing; Vincristine; X-Rays | 1982 |
Cellular targets and host genes in multistage carcinogenesis.
Topics: Animals; Azacitidine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; DNA; Humans; Mice; Models, Biological; Nucleic Acid Hybridization; Oncogenes; Poly A; RNA; RNA, Messenger; Structure-Activity Relationship | 1984 |
Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine.
Topics: 5-Methylcytosine; Animals; Antigens, Neoplasm; Azacitidine; Cell Transformation, Neoplastic; Cytosine; DNA; Ethyl Methanesulfonate; Mammary Neoplasms, Experimental; Mast-Cell Sarcoma; Methylnitronitrosoguanidine; Mice; Mice, Inbred A; Mice, Inbred DBA; Mice, Nude; Mutagens; Neoplasm Transplantation; Phenotype | 1984 |
Inhibition of polyoma gene expression in transformed mouse cells by hypermethylation.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Methylation; Mice; Mice, Inbred Strains; Mutation; Nucleic Acid Hybridization; Plasmids; Polyomavirus | 1984 |
Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells.
Topics: 5-Methylcytosine; Animals; Avian Sarcoma Viruses; Azacitidine; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cytosine; DNA Restriction Enzymes; DNA, Viral; Methylation; Rats; Transcription, Genetic | 1984 |
Genetic analysis of tumorigenesis: XVI. Chromosome changes in azacytidine- and insulin-induced tumorigenesis.
Topics: Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Cricetinae; Cricetulus; Embryo, Mammalian; Insulin; Karyotyping; Neoplasms, Experimental | 1984 |
5-Azacytidine-induced uncoupling of differentiation and tumorigenicity in a murine cell line.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Female; Male; Mice; Mice, Nude; Neoplasm Transplantation; Phenotype | 1984 |
Demethylation of the type I procollagen genes in transformed fibroblasts treated with 5-azacytidine.
Topics: Azacitidine; Cell Line; Cell Transformation, Neoplastic; Collagen; Genes; Humans; Lung; Nucleic Acid Hybridization; Procollagen; Simian virus 40 | 1984 |
Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine.
Topics: Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; DNA; Kidney; Methylation; Mutagenicity Tests; Mutagens; Mutation | 1984 |
Human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma-rays and c-Ha-ras oncogene constitutively produce a large amount of human granulocyte-colony stimulating factor (G-CSF).
Topics: Animals; Azacitidine; Butyrates; Cell Line; Cell Transformation, Neoplastic; Cobalt Radioisotopes; Dexamethasone; Fibroblasts; Gamma Rays; Genes, ras; Granulocyte Colony-Stimulating Factor; Humans; Mice; Mice, Nude; Neoplasms, Experimental | 1994 |
Increased DT-diaphorase activity in transformed and tumorigenic pancreatic acinar cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; In Vitro Techniques; Methylation; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1995 |
Inactivation of a tumor suppressor function in immortal Syrian hamster cells by N-methyl-N'-nitro-N-nitrosoguanidine and by 5-aza-2'-deoxycytidine.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Decitabine; Embryo, Mammalian; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Insulin; Mesocricetus; Methylnitronitrosoguanidine; Mice; Mice, Nude; Phenotype; Platelet-Derived Growth Factor | 1993 |
Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin.
Topics: Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; DNA; DNA Damage; DNA, Satellite; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Lymphocytes; Methylation; Nucleic Acid Denaturation | 1993 |
Comparison of transformation by manganese sulfate and 5-azacytidine in Rat 6 cells overexpressing the c-myc oncogene.
Topics: Animals; Azacitidine; Cell Line; Cell Transformation, Neoplastic; Genes, myc; Manganese Compounds; Manganese Poisoning; Rats; Rats, Inbred F344; Sulfates | 1996 |
Counter-selection for over-expressed human CD44s in primary tumors versus lung metastases in a mouse fibrosarcoma model.
Topics: 3T3 Cells; Animals; Antigens, CD; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Transformed; Cell Survival; Cell Transformation, Neoplastic; Decitabine; Fibrosarcoma; Genes, ras; Humans; Hyaluronan Receptors; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Oncogene Proteins v-sis; Oncogenes; Retroviridae Proteins, Oncogenic; Transfection | 1997 |
Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine-induced carcinogenesis.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Azacitidine; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Chemoprevention; Clone Cells; Collagen; Decitabine; DNA Methylation; Drug Combinations; Female; Genes, ras; Laminin; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasms, Experimental; Phenylacetates; Proteoglycans | 1995 |
Differential expression of stathmin during neoplastic conversion of human prostate epithelial cells is reversed by hypomethylating agent, 5-azacytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; DNA Methylation; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Gene Expression; Humans; Male; Microtubule Proteins; Phosphoproteins; Phosphorylation; Prostate; Prostatic Neoplasms; Stathmin; Tumor Cells, Cultured | 1999 |
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
Topics: 14-3-3 Proteins; Azacitidine; Breast; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; DNA Repair; Epithelial Cells; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Neoplasm Proteins; Protein Biosynthesis; Proteins; Radiation Tolerance; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 2000 |
Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion.
Topics: Animals; Azacitidine; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 11; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, p53; Humans; Mice; Transcriptional Activation; Transfection; Tumor Cells, Cultured; X-Rays | 2000 |
Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16(INK4a) expression.
Topics: Animals; Antigens, Polyomavirus Transforming; Azacitidine; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Epithelial Cells; Female; Gene Expression Regulation; Humans; Oncogene Proteins, Viral; Proteins; Repressor Proteins; Retinoblastoma Protein; Simian virus 40; Transfection; Tumor Suppressor Protein p14ARF | 2001 |
Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Biomarkers, Tumor; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Line, Transformed; Cell Transformation, Neoplastic; Chemotactic Factors; Decitabine; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Rats; RNA, Neoplasm; S100 Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Cancer research. Leukemia protein spurs gene silencing.
Topics: Azacitidine; Cell Division; Cell Transformation, Neoplastic; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Silencing; Genes, Tumor Suppressor; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mutation; Neoplasm Proteins; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Receptors, Retinoic Acid; Tretinoin; Zinc | 2002 |
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor.
Topics: Azacitidine; Binding Sites; Cell Differentiation; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cloning, Molecular; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Exons; Gene Expression; Gene Silencing; Histone Deacetylases; Humans; Leukemia, Promyelocytic, Acute; Mutation; Neoplasm Proteins; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Transcription Factors; Tretinoin; Tumor Cells, Cultured; Zinc | 2002 |
Transformation of BHK 21/13 cells by chemical carcinogens and mutagens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Methylcholanthrene; Mutagens; Neoplasms, Experimental; Retroviridae | 1975 |
Selective techniques for the isolation of morphological revertants of sarcoma virus-transformed cells.
Topics: Animals; Azacitidine; Azaguanine; Cell Line; Cell Separation; Cell Transformation, Neoplastic; Clone Cells; Gammaretrovirus; Mice; Mice, Inbred BALB C; Mitomycins; Mutagens; Neoplasm Transplantation; Sarcoma Viruses, Murine | 1976 |
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Topics: Adipose Tissue; Animals; Azacitidine; Cartilage; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Embryo, Mammalian; Mice; Muscles; Phenotype | 1979 |
Herpes simplex virus type 2 and pseudorabies virus associated growth factors and their role in the latency in vitro.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Viral; Azacitidine; Cell Transformation, Neoplastic; Embryo, Mammalian; Glycoproteins; Growth Substances; HeLa Cells; Herpesvirus 1, Suid; Humans; Mice; Neutralization Tests; Phenotype; Simplexvirus; Tumor Cells, Cultured; Viral Envelope Proteins; Virus Activation | 1992 |
Phenylacetate: a novel nontoxic inducer of tumor cell differentiation.
Topics: Adipose Tissue; Animals; Antineoplastic Agents; Azacitidine; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Decitabine; Gene Expression; Genes, myc; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, Nude; Phenylacetates; RNA, Ribosomal | 1992 |
Repression of SV40 T oncoprotein expression by DMSO.
Topics: Acetamides; Animals; Antigens, Polyomavirus Transforming; Azacitidine; Blotting, Northern; Blotting, Western; Butyrates; Butyric Acid; Cell Line, Transformed; Cell Transformation, Neoplastic; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Insulin; Interferons; Mice; Phenotype; Stem Cells; T-Lymphocytes; Tretinoin | 1992 |
5-azacytidine induces micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; DNA Replication; Dose-Response Relationship, Drug; Embryo, Mammalian; Fibroblasts; Mesocricetus; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Mutagens | 1992 |
Drug-induced revertants of adenovirus-transformed cells: retransformation by 5-azacytidine without reactivation of E1a.
Topics: Adenovirus Early Proteins; Adenoviruses, Human; Animals; Antigens, Viral, Tumor; Azacitidine; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Clone Cells; DNA, Viral; Oncogene Proteins, Viral; Rats; Restriction Mapping; RNA, Viral | 1990 |
Induction of mutagenesis and transformation in BALB/c-3T3 clone A31-1 cells by diverse chemical carcinogens.
Topics: Alkylating Agents; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutation; Polycyclic Compounds | 1990 |
Effects of 5-azacytidine in Syrian golden hamsters: toxicity, tumorigenicity, and differential modulation of bronchial carcinogenesis.
Topics: Animals; Azacitidine; Bronchial Neoplasms; Cell Transformation, Neoplastic; Cricetinae; Female; Mesocricetus; Pilot Projects | 1990 |
Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Differentiation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Decitabine; DNA; Genes, ras; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger | 1991 |
Effect of myogenic determination on tumorigenicity of chemically transformed 10T1/2 cells.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Differentiation; Cell Fusion; Cell Line; Cell Transformation, Neoplastic; Clone Cells; DNA-Binding Proteins; Fluorescent Antibody Technique; Genetic Vectors; Methylcholanthrene; Mice; Muscle Proteins; Muscles; MyoD Protein; Myosins; Neoplasms, Experimental; RNA, Neoplasm; Transfection | 1991 |
Short-term treatment with gamma interferon induces stable reversion of ras-transformed mouse fibroblasts.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; Fibroblasts; Genes, ras; Interferon-gamma; Mice; Oncogenes; Ouabain; Recombinant Proteins; RNA | 1991 |
5-Azacytidine-induced demethylation of DNA to senescent level does not block proliferation of human fibroblasts.
Topics: Azacitidine; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cellular Senescence; DNA Damage; Fibroblasts; Humans; RNA; Simian virus 40; Uridine | 1991 |
Effects of 5-azacytidine on the progressive nature of cell transformation.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Methylation; Mice | 1985 |
Interaction between nontransforming retroviruses and chemicals in cells in vitro: association with progression to neoplastic phenotypes.
Topics: Animals; Azacitidine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; DNA; Methylation; Oncogenes; Phenotype; Rats; Rats, Inbred F344; Retroviridae | 1985 |
Adipocyte differentiation in CHEF cells.
Topics: Adipose Tissue; Animals; Azacitidine; Carcinogens; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Culture Media; Embryo, Mammalian; Fibroblasts | 1985 |
Effects of 5-azacytidine on expression of endogenous retrovirus-related sequences in C3H 10T1/2 cells.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA, Viral; Fibroblasts; Genes, Intracisternal A-Particle; Mammary Tumor Virus, Mouse; Methylation; Mice; Mice, Inbred C3H; Poly A; Repetitive Sequences, Nucleic Acid; Retroviridae; RNA; RNA, Messenger; RNA, Viral; Transcription, Genetic | 1986 |
In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Decitabine; DNA; Dose-Response Relationship, Drug; Epithelium; Male; Methylation; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Inbred F344; Time Factors; Trachea | 1986 |
Dissociation of contact-noninhibition in vitro and tumorigenicity in vivo.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cells, Cultured; Contact Inhibition; Furans; Mice; Neoplasms, Experimental | 1986 |
Growth factors, oncogenes, and interferons.
Topics: Azacitidine; Cell Line; Cell Transformation, Neoplastic; DNA; Gene Expression Regulation; Glycoproteins; Growth Substances; Interferon Type I; Interferons; Oncogenes; Platelet-Derived Growth Factor; RNA, Messenger; Tumor Necrosis Factor-alpha | 1986 |
DNA methylation affecting the transforming activity of the human Ha-ras oncogene.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Humans; Methylation; Mice; Oncogenes; Plasmids; Transfection | 1987 |
Interferon-induced revertants of ras-transformed cells: resistance to transformation by specific oncogenes and retransformation by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Interferon Type I; L Cells; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Retroviridae; RNA, Messenger | 1987 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Metallothionein; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mutation; Proto-Oncogenes; Tetradecanoylphorbol Acetate | 1987 |
Modulation of N-myc expression, but not tumorigenicity, accompanies phenotypic conversion of neuroblastoma cells in prolonged culture.
Topics: Azacitidine; Cell Line; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Humans; Methylation; Neuroblastoma; Oncogenes; Phenotype; Time Factors; Tumor Cells, Cultured | 1988 |
Capture and characterization of 5-aza-2'-deoxycytidine-treated C3H/10T1/2 cells prior to transformation.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Decitabine; Mice; Mice, Inbred C3H; Nucleic Acid Hybridization; RNA | 1988 |
Anti-tumor surveillance of non-contact-inhibited transformed cell lines.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Transformed; Cell Transformation, Neoplastic; Histocompatibility Antigens; Immunity, Cellular; Immunologic Surveillance; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Phenotype | 1988 |
Effect of cellular determination on oncogenic transformation by chemicals and oncogenes.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Genes, ras; GTP-Binding Proteins; Methylcholanthrene; Mice; Mice, Nude; Muscles; Neoplasm Transplantation; Phenotype; Proto-Oncogene Proteins; RNA, Messenger | 1988 |
Modulation of the human Harvey-ras oncogene expression by DNA methylation.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; DNA; Gene Expression Regulation; Genes, ras; Humans; Methylation; Mice; Restriction Mapping; Transfection | 1988 |
Spontaneous and 5-azacytidine-induced revertants of methionine-dependent tumor-derived and H-ras-1-transformed cells.
Topics: Animals; Azacitidine; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Culture Media; Ethyl Methanesulfonate; Homocysteine; Methionine; Methylation; Oncogenes; Tumor Cells, Cultured | 1989 |
Differential activation of the hprt gene on the inactive X chromosome in primary and transformed Chinese hamster cells.
Topics: Animals; Azacitidine; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Dosage Compensation, Genetic; Female; Gene Expression Regulation; Hypoxanthine Phosphoribosyltransferase; Mutation; Phenotype; Transcriptional Activation | 1989 |
In vitro neoplastic progression of rat tracheal epithelial cells transformed by diverse carcinogens.
Topics: Animals; Azacitidine; Carcinogens; Cell Transformation, Neoplastic; Epithelium; Methylnitronitrosoguanidine; Precancerous Conditions; Rats; Trachea; Tracheal Neoplasms | 1989 |
Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine.
Topics: Animals; Azacitidine; Base Sequence; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cloning, Molecular; Gene Expression Regulation; Genes; Kirsten murine sarcoma virus; Molecular Sequence Data; Oligonucleotide Probes; Promoter Regions, Genetic; Rats; Thyroglobulin; Thyroid Gland; Transcription, Genetic; Transfection | 1989 |
5-azacytidine-induced tumorous transformation and DNA hypomethylation in Nicotiana tissue cultures.
Topics: 5-Methylcytosine; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Cytosine; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoresis, Agar Gel; Methylation; Plant Tumors; Thymidine; Time Factors | 1989 |
Arabinofuranosyl-5-azacytosine: activity against human tumors in athymic mice.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Transformation, Neoplastic; Cytarabine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Stereoisomerism; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1989 |
Isolation of temperature-sensitive mutants of murine sarcoma virus.
Topics: Animals; Azacitidine; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Contact Inhibition; Gammaretrovirus; Helper Viruses; Kidney; Leukemia Virus, Murine; Mice; Mutagens; Mutation; Nucleic Acid Hybridization; Rats; RNA, Viral; Sarcoma, Experimental; Temperature; Tritium; Viral Plaque Assay; Virus Replication | 1972 |
Characterization of chicken sarcoma viruses induced with chemical carcinogens and mutagens in transformed hamster cells.
Topics: Alpharetrovirus; Animals; Azacitidine; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Cricetinae; DNA Nucleotidyltransferases; Genetic Code; Methylcholanthrene; Mutation; Neoplasms, Experimental; Quinolines; RNA, Viral | 1972 |
Virus production induced by various chemical carcinogens in a virogenic hamster cell line transformed by Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Azacitidine; Benzopyrenes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chickens; Cricetinae; Lectins; Methylcholanthrene; Mutagens; Neoplasm Transplantation; Quinolines; Sarcoma, Experimental; Transplantation, Heterologous; Urethane; Virus Cultivation | 1972 |
The selective isolation of temperature-sensitive mutants of Rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Azacitidine; Bromodeoxyuridine; Cell Line; Cell Transformation, Neoplastic; Chick Embryo; Fibroblasts; Light; Mice; Mutagens; Mutation; Temperature; Virus Replication | 1973 |
Characterization of two conditional early mutants of Rous sarcoma virus.
Topics: Alpharetrovirus; Animals; Antigens, Viral; Avian Sarcoma Viruses; Azacitidine; Carbon Isotopes; Cell Transformation, Neoplastic; Chick Embryo; Culture Techniques; Fibroblasts; Genetic Complementation Test; Hydrogen-Ion Concentration; Mutagens; Mutation; Polynucleotides; Recombination, Genetic; RNA-Directed DNA Polymerase; Temperature; Templates, Genetic; Tritium; Virus Replication | 1973 |