azacitidine has been researched along with Carcinoma, Non-Small Cell Lung in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.41) | 18.7374 |
| 1990's | 3 (3.61) | 18.2507 |
| 2000's | 32 (38.55) | 29.6817 |
| 2010's | 45 (54.22) | 24.3611 |
| 2020's | 1 (1.20) | 2.80 |
| Authors | Studies |
|---|---|
| Bhagat, TD; Cheng, H; Fan, N; Gucalp, R; Halmos, B; Kim, M; Perez-Soler, R; Piperdi, B; Shah, CD; Spivack, SD; Verma, A; Zou, Y | 1 |
| Liu, Y; Luo, F; Tu, L; Wang, Y; Zhang, N; Zhao, M | 1 |
| Bai, Y; Chang, D; Li, M; Liu, C; Lv, D; Sun, G; Zhang, X | 1 |
| Ding, Z; Huang, JA; Lei, Z; Li, W; Liu, Z; Qin, H; Shen, D; Zeng, Y; Zhu, J | 1 |
| Anagnostou, V; Ballew, M; Baylin, SB; Chiappinelli, KB; DeStefano Shields, CE; Hellmann, MD; Hicks, J; Niknafs, N; Stone, M; Strick, R; Strissel, PL; Topper, MJ; Tran, PT; Vaz, M; Velculescu, VE; Wenzel, A; Yen, RC; Zahnow, CA | 1 |
| Chen, Y; Rong, X; Su, L; Zhang, X | 1 |
| Chen, H; Ding, X; Hua, CS; Ma, DC; Wang, WS; Wu, F; Zhang, CD; Zhao, J | 1 |
| Besse, B; Domine Gomez, M; Fandi, A; Felip, E; Garassino, MC; Garrido, P; Giaccone, G; Levy, BP; MacBeth, KJ; Menezes, D; Paz-Ares, L; Piperdi, B; Ponce-Aix, S; Risueño, A; Slepetis, R; Wu, X | 1 |
| Chami, H; Kadara, H; Khalil, A; Nehme, E; Nemer, G; Rahal, Z; Sinjab, A | 1 |
| Cao, HX; Feng, JF; Li, XY; Ma, R; Wu, JQ; Wu, JZ; Zhong, YJ | 1 |
| Agarwal, C; Agarwal, R; Chan, D; Mateen, S; Raina, K | 1 |
| Dong, YQ; Ji, T; Liang, JS; Xu, JH; Yin, GL; Zhang, XM; Zhu, SB | 1 |
| Baylin, SB; Brahmer, JR; Brock, MV; Carvajal, RD; Demeyer, T; Du, Z; Easton, K; Easwaran, H; Jones, PA; Juergens, RA; Koch, A; Laird, PW; Mohammad, HP; Pardoll, D; Parsana, P; Rodgers, K; Rudin, CM; Taube, JM; Topalian, SL; Tsai, S; Tykodi, SS; Vancriekinge, W; Vendetti, F; Wang, W; Weisenberger, DJ; Wrangle, J; Yen, RW; Zahnow, CA | 1 |
| Han, J; Heo, K; Hong, SH; Hwang, JA; Kim, DH; Kim, Y; Kim, YH; Lee, BB; Lee, YS; Park, SE; Shim, YM | 1 |
| Cho, YG; Han, J; Han, JY; Hong, SH; Hwang, JA; Kim, DH; Kim, Y; Kim, YH; Lee, J; Lee, YS; Shim, YM | 1 |
| Han, L; Hu, Y; Li, X; Tao, H; Wang, J; Yang, B; Zhang, S | 1 |
| Chen, L; Huang, G; Ren, J; Song, H; Wang, R | 1 |
| Chen, LB; Guan, XX; Lu, XX; Tong, JD; Wang, JZ; Wang, Z; Zhang, YW; Zheng, Y | 1 |
| Becker, N; Effenberger, K; Esteller, M; Hagmann, W; Izbicki, JR; Kemming, D; Kim, SZ; Lamszus, K; Pantel, K; Riethdorf, S; Risch, A; Sandoval, J; Uzunoglu, FG; Westphal, M; Wikman, H; Wrage, M | 1 |
| Fan, C; Jiang, G; Lin, X; Liu, Y; Miao, Y; Wang, E; Wang, L; Xu, X; Yu, J; Zhang, X; Zhang, Y | 1 |
| Baylin, SB; Dobromilskaya, I; Easwaran, H; Huang, P; Poirier, JT; Rudin, CM; Topper, M; Vendetti, FP; Wrangle, J | 1 |
| Berdel, WE; Edemir, B; Füller, M; Göllner, S; Klein, M; Müller-Tidow, C; Qianli, J; Rohde, C; Schmidt, E; Schulze, I; Tschanter, P | 1 |
| Drzewiecka, H; Dyszkiewicz, W; Gałęcki, B; Jagodziński, PP; Jarmołowska-Jurczyszyn, D; Kluk, A | 2 |
| Dai, SP; Ding, N; Han, L; Han, YW; Xie, C; Zhang, YJ | 1 |
| Weintraub, K | 1 |
| Carter, CA; Day, RM; Lybeck, M; Oronsky, A; Oronsky, B; Oronsky, N; Richard, P; Scicinski, J; Zeman, K | 1 |
| Jelicks, L; Liang, Y; Liu, J; Ma, S; Mei, J; Perez-Soler, R; Zeng, J; Zou, Y | 1 |
| Bai, J; Du, Z; Feng, X; Li, A; Liu, B; Luan, J; Song, J; Sun, X; Wang, H; Zhang, L | 1 |
| Du, W; Huang, JA; Lei, Z; Liu, Z; Qian, Q; Qin, H; Shen, D; Zeng, Y; Zhu, J | 1 |
| Hu, FH; Huang, WJ; Jen, J; Liao, SY; Lin, P; Lu, YH; Shieh, JM; Tang, YA; Wang, TW; Wang, YC; Wang, YJ; Yeh, YL | 1 |
| Cha, SI; Chae, MH; Choi, JE; Jheon, S; Jung, TH; Kim, CH; Kim, DS; Kim, EJ; Park, JY | 1 |
| Al-Sarraf, N; Baird, AM; Cathcart, MC; Gray, SG; McGovern, E; O'Byrne, KJ | 1 |
| Belda-Iniesta, C; Cejas, P; Cortes-Sempere, M; de CastroCarpeño, J; Ibanez de Caceres, I; López-Ríos, F; Machado-Pinilla, R; Manguán-García, C; Moratilla, C; Nistal, M; Paz-Ares, L; Perona, R; Rodriguez-Fanjul, V | 1 |
| Chen, BH; Hsu, HS; Lee, SH; Tsai, WC; Tseng, RC; Tzao, C; Wang, YC | 1 |
| Li, HL; Ma, AN | 1 |
| Bartling, B; Hofmann, HS; Rehbein, G; Silber, RE; Simm, A | 1 |
| Hsu, CP; Ko, JL; Lai, CH; Liu, YF; Tang, LC; Tang, SC; Wong, RH; Wu, MF | 1 |
| Al-Sohaily, S; Cooper, WA; Kennedy, CW; Kohonen-Corish, MR; McCaughan, BC; Mladenova, DN; Pangon, L; Selinger, CI; Stirzaker, C | 1 |
| Hoshino, H; Moriya, Y; Okamoto, T; Suzuki, M; Tamura, H; Yoshida, S; Yoshino, I | 1 |
| Hu, CH; Wu, F | 1 |
| Cao, B; Guo, M; Hoque, MO; Jia, Y; Yang, Y; Yin, D; Yu, Y | 1 |
| Altenberger, C; Arns, BM; Babinsky, V; Döme, B; End-Pfützenreuter, A; Grin, Y; Heller, G; Klepetko, W; Lang, G; Minichsdorfer, C; Noll, C; Weinzierl, M; Ziegler, B; Zielinski, CC; Zöchbauer-Müller, S | 1 |
| Kelley, N; Tennis, MA; Vanscoyk, MM; Wilson, LA; Winn, RA | 1 |
| Baylin, SB; Belinsky, SA; Brock, MV; Coleman, B; Delgado, IE; Franco, N; Herman, JG; Hooker, CM; Juergens, RA; Lee, B; Murphy, SC; Rodgers, K; Rudek, MA; Rudin, CM; Sebree, R; Tsai, S; Vendetti, FP; Wrangle, J; Zhao, M | 1 |
| Bermejo, JL; Claus, R; Dienemann, H; Gu, L; Jacobsson, H; Meister, M; Muley, T; Peil, B; Plass, C; Risch, A; Sarkisyan, N; Scherf, DB | 1 |
| Aimiuwu, J; Chan, KK; Chu, BF; Grever, MR; Karpenko, MJ; Liu, Z; Otterson, GA; Villalona-Calero, MA | 1 |
| Fang, HL; Jin, YT; Yu, ZC; Zhu, HB | 1 |
| Chang, JW; Chen, CY; Chen, JT; Lin, RK; Lu, YP; Shih, CM; Tseng, RC; Wang, YC | 1 |
| Alder, H; Croce, CM; Kaiser, LR; Kuroki, T; Matsuyama, A; Trapasso, F; Williams, NN; Yendamuri, S | 1 |
| Brambilla, E; Gazdar, AF; Minna, JD; Padar, A; Sathyanarayana, UG; Takahashi, T; Toyooka, S | 1 |
| Gazdar, AF; Lam, S; Miyajima, K; Padar, A; Reddy, JL; Sathyanarayana, UG; Shivapurkar, N; Tockman, MS; Toyooka, KO; Toyooka, S; Toyota, M | 1 |
| Euhus, DM; Gazdar, AF; Heda, S; Lewis, C; Minna, JD; Rathi, A; Roth, JA; Sugio, K; Takahashi, T; Tonk, V; Virmani, A | 1 |
| Heasley, LE; Winn, RA | 1 |
| Hong, WK; Mao, L; Sun, SY; Tang, X; Wistuba, II; Wu, W | 1 |
| Fujisawa, T; Gazdar, AF; Iizasa, T; Sathyanarayana, UG; Shigematsu, H; Shivapurkar, N; Suzuki, M; Takahashi, T | 1 |
| Hirohashi, S; Hosoda, H; Imoto, I; Inazawa, J; Inoue, J; Izumi, H; Shibata, T; Sunamori, M; Yokoi, S | 1 |
| End-Pfützenreuter, A; Fong, KM; Gazdar, AF; Girard, L; Heller, G; Lang, G; Minna, JD; Seidl, S; Zielinski, CC; Zöchbauer-Müller, S | 1 |
| Brena, RM; Hackanson, B; Morrison, C; Otterson, GA; Plass, C; Tada, Y | 1 |
| Ando, S; Chen, H; Iida, T; Kimura, H; Nakagawara, A; Nakajima, T; Nakamura, Y; Ohira, M; Suzuki, M | 1 |
| Berenguer, J; Borczuk, AC; Hei, TK; Powell, CA; Shao, G; Zhao, Y | 1 |
| Cantor, JP; Collins, JE; Druck, T; Friedberg, JS; Han, SY; Huebner, K; Iliopoulos, D; Lakshman, TV; McCorkell, KA; Rao, AS; Semba, S; Wachsberger, P | 1 |
| Chen, GA; Figg, WD; Fischette, MR; Hancox, A; Hong, JA; Kunst, TF; Li, X; Murgo, AJ; Nguyen, DM; Pishchik, V; Schrump, DS; Steinberg, SM; Zhao, M | 1 |
| Fields, CR; Pan, YX; Robertson, KD; Su, N; Zhong, S | 1 |
| Fujisawa, T; Gazdar, AF; Iizasa, T; Minna, JD; Shames, DS; Shigematsu, H; Shivapurkar, N; Sunaga, N; Suzuki, M; Takahashi, T | 1 |
| Chang, HC; Cho, CY; Hung, WC | 1 |
| Dacic, S; Guo, M; Landreneau, R; Siegfried, JM; Sun, Q; Yu, J; Yue, W; Zhang, L; Zhou, W | 1 |
| Clanet, C; Favre, G; He, B; Jablons, D; Marty-Detraves, C; Mazières, J; Nieto-Acosta, J; Pradines, A; Tovar, D | 1 |
| Hsu, HS; Hsu, WH; Lin, RK; Tseng, C; Tseng, RC; Wang, YC; Wen, CK | 1 |
| Crowley, JJ; Goodwin, JW; Livingston, RB; Panella, TJ; Williamson, SK | 1 |
| Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
| Ayoub, J; Belanger, K; Bouffard, DY; Dionne, J; Momparler, LF; Momparler, RL | 1 |
| Ayoub, J; Eliopoulos, N; Momparler, RL | 1 |
| DiLeone, L; Filho, AF; Garbino, C; Gorini, CN; Mans, DR; Muse, I; Sabini, G; Schunemann, H; Schwartsmann, G | 1 |
| Chen, GA; Fischette, MR; Guo, ZS; Hong, JA; Nguyen, DM; Ohnmacht, GA; Schrump, DS; Weiser, TS | 1 |
| Ashfaq, R; Fong, KM; Gazdar, AF; Geradts, J; Lam, S; Maitra, A; Milchgrub, S; Minna, JD; Virmani, AK; Zöchbauer-Müller, S | 1 |
| Feng, G; Lotan, R; Xu, X; Youssef, EM | 1 |
| Ayoub, J; Momparler, RL | 1 |
| Issa, JP; Kemp, BL; Khuri, FR; Kurie, JM; Lee, HY; Lee, JI; Liu, DD; Mao, L; Soria, JC; Wang, L | 1 |
| Dallol, A; Forgacs, E; Kishida, T; Latif, F; Maher, ER; Martinez, A; Minna, JD; Rabbitts, P; Sekido, Y; Walker, R | 1 |
| Asmeron, Y; Blayney, D; Carr, BI; Doroshow, JH; Goldberg, D; Leong, L; Rahbar, S | 1 |
| Carr, DT; Dhingra, HM; Holoye, PY; Lee, JS; Murphy, WK; Umsawasdi, T | 1 |
3 review(s) available for azacitidine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies.
Topics: Antibodies, Monoclonal; Azacitidine; Azetidines; Benzamides; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; CpG Islands; Disease Progression; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Histones; Humans; Hydralazine; Immunotherapy; Lung Neoplasms; Molecular Targeted Therapy; Mutation; Neoplasm Recurrence, Local; Nitro Compounds; Nivolumab; Prognosis; Pyridines; Treatment Outcome; Valproic Acid | 2016 |
Decitabine: 2'-deoxy-5-azacytidine, Aza dC, DAC, dezocitidine, NSC 127716.
Topics: Anemia, Sickle Cell; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Decitabine; Humans; Leukemia; Lung Neoplasms; Male; Prostatic Neoplasms | 2003 |
Evaluation of an inhibitor of DNA methylation, 5-aza-2'-deoxycytidine, for the treatment of lung cancer and the future role of gene therapy.
Topics: Animals; Antibiotics, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; DNA Methylation; DNA Modification Methylases; Evaluation Studies as Topic; Forecasting; Genetic Therapy; Humans; Lung Neoplasms | 2000 |
8 trial(s) available for azacitidine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Randomised phase 2 study of pembrolizumab plus CC-486 versus pembrolizumab plus placebo in patients with previously treated advanced non-small cell lung cancer.
Topics: Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Progression-Free Survival; Survival Rate; Treatment Outcome | 2019 |
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cohort Studies; Combined Modality Therapy; Disease Progression; Disease-Free Survival; DNA Methylation; Epigenesis, Genetic; Female; Genetic Therapy; Histones; Humans; Lung Neoplasms; Male; Middle Aged; Pyridines | 2011 |
Phase I study of 5-aza-2'-deoxycytidine in combination with valproic acid in non-small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Dose-Response Relationship, Drug; Drug Synergism; Female; Histone Deacetylase Inhibitors; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Treatment Outcome; Valproic Acid | 2013 |
Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura.
Topics: Adult; Aged; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Decitabine; DNA Modification Methylases; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Genes, p16; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Membrane Proteins; Mesothelioma; Middle Aged; Neoplasm Proteins; Pleural Neoplasms; Transcriptional Activation | 2006 |
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; CpG Islands; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm; Down-Regulation; Epigenesis, Genetic; Extracellular Matrix Proteins; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Membrane Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic; Receptor Activity-Modifying Protein 2; Receptor Activity-Modifying Proteins; Receptors, Immunologic; Roundabout Proteins; Tumor Cells, Cultured | 2007 |
Phase II trial and cost analysis of fazarabine in advanced non-small cell carcinoma of the lung: a Southwest Oncology Group study.
Topics: Adult; Aged; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Middle Aged | 1995 |
Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Decitabine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Tumor Cells, Cultured | 1997 |
A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cisplatin; Decitabine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged | 2000 |
72 other study(ies) available for azacitidine and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
First-in-human study of inhaled Azacitidine in patients with advanced non-small cell lung cancer.
Topics: Animals; Azacitidine; Carcinoma, Non-Small-Cell Lung; DNA Methylation; Humans; Lung Neoplasms; Mice; Neoplasm Recurrence, Local; Treatment Outcome | 2021 |
Decitabine reverses TGF-β1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Survival; Decitabine; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Neoplasms, Experimental; Transforming Growth Factor beta1; Tumor Cells, Cultured; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
Hypermethylation of miRNA-589 promoter leads to upregulation of HDAC5 which promotes malignancy in non-small cell lung cancer.
Topics: Aged; Animals; Azacitidine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Male; Mice; MicroRNAs; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2017 |
Methylated +322-327 CpG site decreases hOGG1 mRNA expression in non-small cell lung cancer.
Topics: 5' Untranslated Regions; 8-Hydroxy-2'-Deoxyguanosine; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Deoxyguanosine; DNA Glycosylases; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Sp1 Transcription Factor | 2017 |
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer.
Topics: Animals; Antigen Presentation; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Therapy, Combination; Histone Deacetylase Inhibitors; Hydroxamic Acids; Immunotherapy; Lung Neoplasms; Mice; T-Lymphocytes; Transcriptome; Tumor Escape; Tumor Microenvironment | 2017 |
Methylation-mediated loss of SFRP2 enhances invasiveness of non-small cell lung cancer cells.
Topics: A549 Cells; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Movement; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Matrix Metalloproteinase 9; Membrane Proteins; Neoplasm Invasiveness; Promoter Regions, Genetic; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1 | 2018 |
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Topics: A549 Cells; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Deoxycytidine; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Promoter Regions, Genetic | 2018 |
Epigenetic Suppression of the T-box Subfamily 2 (
Topics: Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Multigene Family; Neoplasm Staging; T-Box Domain Proteins | 2019 |
Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; CpG Islands; Decitabine; DNA Methylation; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Quinazolines | 2013 |
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.
Topics: Antioxidants; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Decitabine; Drug Synergism; Enzyme Inhibitors; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Silybin; Silymarin; Transcription Factors; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
Effect of 5-aza-2'-deoxycytidine on cell proliferation of non- small cell lung cancer cell line A549 cells and expression of the TFPI-2 gene.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Flow Cytometry; Glycoproteins; Humans; Lung Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2013 |
Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Epigenomics; Humans; Immunotherapy; Lung Neoplasms; Programmed Cell Death 1 Receptor; Signal Transduction; Up-Regulation | 2013 |
HOXA11 hypermethylation is associated with progression of non-small cell lung cancer.
Topics: Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Decitabine; Disease Progression; DNA Methylation; Female; Homeodomain Proteins; Humans; Lung Neoplasms; Male; Middle Aged; Paraffin Embedding; Promoter Regions, Genetic; Transfection | 2013 |
Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis.
Topics: Adult; Azacitidine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Knockdown Techniques; Gene Silencing; Humans; Lung Neoplasms; Male; Neoplasm Invasiveness; Phenotype; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; Sulfotransferases | 2013 |
Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines.
Topics: Antibiotics, Antineoplastic; Apoptosis; Azacitidine; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Down-Regulation; Doxorubicin; Humans; Lung Neoplasms; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; Oligonucleotides, Antisense; Promoter Regions, Genetic; Sequence Alignment; Up-Regulation | 2013 |
Secreted frizzled related protein 1 modulates taxane resistance of human lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Agents; Azacitidine; Bridged-Ring Compounds; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Membrane Proteins; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Sulfonamides; Taxoids; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2014 |
Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; RNA, Messenger | 2014 |
Identification of HERC5 and its potential role in NSCLC progression.
Topics: Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromosome Deletion; Chromosomes, Human, Pair 4; Decitabine; DNA Copy Number Variations; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Promoter Regions, Genetic; Survival Analysis | 2015 |
Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis.
Topics: Aged; Azacitidine; beta Catenin; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Membrane; Decitabine; DNA Methylation; Female; Gene Silencing; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Promoter Regions, Genetic; Wnt Signaling Pathway | 2014 |
Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; DNA Methylation; Drug Evaluation, Preclinical; Epigenesis, Genetic; Female; Histones; Humans; Irinotecan; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Pyridines | 2015 |
5-azacytidine enhances efficacy of multiple chemotherapy drugs in AML and lung cancer with modulation of CpG methylation.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Non-Small-Cell Lung; CpG Islands; DNA Methylation; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Tumor Cells, Cultured; U937 Cells | 2015 |
Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer.
Topics: Adult; Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Estradiol Dehydrogenases; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic; Tumor Burden | 2015 |
Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Humans; Lung Neoplasms; Phenotype | 2015 |
Take two: Combining immunotherapy with epigenetic drugs to tackle cancer.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; Carcinoma, Non-Small-Cell Lung; Epigenesis, Genetic; Humans; Immunotherapy; Lung Neoplasms; Nivolumab; Pyridines | 2016 |
Pax5 Re-expression in H460 Cells Treated with the Combination of Demethylating Agent and Histone Deacetylase Inhibitor is Associated with the Enhancement of P53 Binding to Pax5 Promoter Region.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; PAX5 Transcription Factor; Promoter Regions, Genetic; Tumor Suppressor Protein p53; Vorinostat | 2017 |
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Topics: Animals; Azacitidine; Benzamides; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Promoter Regions, Genetic; Pyridines | 2016 |
Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Connective Tissue Growth Factor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Tumor Cells, Cultured | 2016 |
Aberrant promoter methylation of hOGG1 may be associated with increased risk of non-small cell lung cancer.
Topics: A549 Cells; Aged; Asian People; Azacitidine; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Case-Control Studies; Chi-Square Distribution; China; Decitabine; DNA Glycosylases; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Logistic Models; Lung Neoplasms; Male; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Assessment; Risk Factors | 2017 |
A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer.
Topics: Acetylation; Amides; Animals; Apoptosis; Azacitidine; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Decitabine; DNA Methylation; Drug Synergism; Drug Therapy, Combination; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2017 |
Aberrant methylation of ADAMTS1 in non-small cell lung cancer.
Topics: ADAM Proteins; ADAMTS1 Protein; Adult; Aged; Aged, 80 and over; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chi-Square Distribution; Decitabine; DNA Methylation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Chromatin Assembly and Disassembly; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Phenylbutyrates; Receptors, Prostaglandin E; RNA, Messenger; Tumor Cells, Cultured; Vorinostat | 2009 |
IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HeLa Cells; HT29 Cells; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Kaplan-Meier Estimate; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Cells, Cultured | 2010 |
SLIT2 attenuation during lung cancer progression deregulates beta-catenin and E-cadherin and associates with poor prognosis.
Topics: Azacitidine; beta Catenin; beta-Transducin Repeat-Containing Proteins; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Movement; Decitabine; Disease Progression; DNA Methylation; Gene Knockdown Techniques; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Nerve Tissue Proteins; Oncogene Protein v-akt; Prognosis; Promoter Regions, Genetic; Receptors, Immunologic; RNA, Messenger; Roundabout Proteins | 2010 |
Induction of apoptosis of non-small cell lung cancer by a methylated oligonucleotide targeting survivin gene.
Topics: Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Modification Methylases; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Microtubule-Associated Proteins; Oligonucleotides; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Transfection | 2010 |
Porcupine expression is associated with the expression of S100P and other cancer-related molecules in non-small cell lung carcinoma.
Topics: Acyltransferases; Azacitidine; Calcium-Binding Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Membrane Proteins; Neoplasm Proteins; RNA Interference; RNA, Messenger; Time Factors; Transcriptional Activation | 2010 |
Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.
Topics: Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Glutathione Transferase; Humans; Lung Neoplasms; Male; Sp1 Transcription Factor | 2011 |
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatin Immunoprecipitation; Cohort Studies; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Lung Neoplasms; Male; Matrix Attachment Region Binding Proteins; Middle Aged; Neoplasm Staging; Prognosis; Tissue Array Analysis | 2011 |
Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma.
Topics: Adult; Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Japan; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Pneumonectomy; Prognosis; Proportional Hazards Models; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; RNA, Neoplasm; Sampling Studies | 2011 |
[Reversal effect of 5-Aza-dc on cisplatin-resistance in human NSCLC cells in vitro].
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; RNA, Messenger | 2011 |
AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer.
Topics: Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytokines; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Suppressor Proteins | 2012 |
Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers.
Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Profiling; Gene Silencing; Humans; Hydroxamic Acids; Lung; Lung Neoplasms; Male; MicroRNAs; Middle Aged; Molecular Targeted Therapy; Oligonucleotide Array Sequence Analysis | 2012 |
Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer.
Topics: Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epithelial Cells; Lung; Lung Neoplasms; Phenotype; Promoter Regions, Genetic; Smoke; Smoking; Wnt Proteins | 2012 |
Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
Topics: Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, Nicotinic | 2013 |
[Effects of 5-Aza-2-deoxycytidine on DNA methylation of anti-oncogenes in non-small cell lung cancer cells].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Differentiation; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphatic Metastasis; Male; Membrane Proteins; Neoplasm Staging; RNA, Messenger; Tumor Suppressor Proteins | 2012 |
Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Alleles; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Decitabine; DNA Methylation; DNA-Binding Proteins; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; RNA, Messenger; Sputum | 2003 |
Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer.
Topics: Aged; Aged, 80 and over; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 3; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Membrane Glycoproteins; Middle Aged; Neoplasm Proteins; Promoter Regions, Genetic; Semaphorins; Tumor Cells, Cultured | 2003 |
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Topics: Azacitidine; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; Humans; Kalinin; Laminin; Lung Neoplasms; Lymphocytes; Methylation; Models, Genetic; Mouth Mucosa; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Epigenetic down-regulation of death-associated protein kinase in lung cancers.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cells, Cultured; CpG Islands; Death-Associated Protein Kinases; Decitabine; DNA; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Exons; Gene Silencing; Genetic Techniques; Humans; Lung Neoplasms; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sulfites; Time Factors; Tumor Cells, Cultured | 2003 |
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cyclin D2; Cyclins; DNA Methylation; Female; Humans; Lung Neoplasms; Middle Aged; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth.
Topics: Azacitidine; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; Desmoplakins; DNA Modification Methylases; gamma Catenin; Humans; Hydroxamic Acids; Lung Neoplasms; Neoplasm Proteins; Trans-Activators | 2004 |
Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cloning, Molecular; Coloring Agents; Death-Associated Protein Kinases; Decitabine; DNA Fragmentation; DNA Methylation; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fas Ligand Protein; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Membrane Glycoproteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Treatment Outcome; Tumor Necrosis Factor-alpha | 2004 |
Aberrant methylation of Reprimo in lung cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Cycle; Cell Cycle Proteins; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Genes, p53; Glycoproteins; Humans; Lung Neoplasms; Lymphocytes; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2005 |
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Chromosomes, Human, Pair 9; CpG Islands; Decitabine; DNA; DNA Methylation; Epigenesis, Genetic; Female; Gene Deletion; Gene Silencing; Humans; Male; Nerve Tissue Proteins; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2005 |
Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; Lung Neoplasms; Membrane Proteins; Microfilament Proteins; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2006 |
Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.
Topics: Acetylation; Azacitidine; Blotting, Northern; Blotting, Southern; Carcinoma, Non-Small-Cell Lung; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Methyl-CpG-Binding Protein 2; Mutagenesis; Promoter Regions, Genetic; Sequence Analysis, DNA; Upstream Stimulatory Factors | 2006 |
Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer.
Topics: Aged; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung; Lung Neoplasms; Male; Neoplasm Staging; ras Guanine Nucleotide Exchange Factors; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins | 2006 |
Epigenetic inactivation of Betaig-h3 gene in human cancer cells.
Topics: Azacitidine; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Humans; Luciferases; Lung Neoplasms; Male; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Transforming Growth Factor beta | 2006 |
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity.
Topics: Acid Anhydride Hydrolases; Animals; Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Caspases; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Oxidoreductases; Promoter Regions, Genetic; Transgenes; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2007 |
Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.
Topics: Acetylation; Adenocarcinoma; Azacitidine; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chromatin Immunoprecipitation; Colony-Forming Units Assay; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2007 |
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; CpG Islands; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2007 |
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Topics: Aged; Amino Acid Motifs; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Membrane Glycoproteins; Mutation; Neoplasm Invasiveness; Promoter Regions, Genetic; ras Proteins | 2007 |
Epigenetic regulation of RhoB loss of expression in lung cancer.
Topics: Azacitidine; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Immunoblotting; Lung Neoplasms; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; rhoB GTP-Binding Protein; Sulfites; Tandem Repeat Sequences | 2007 |
Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis.
Topics: Active Transport, Cell Nucleus; Axin Protein; Azacitidine; beta Catenin; beta-Transducin Repeat-Containing Proteins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Nucleus; Cytoskeletal Proteins; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Humans; Hydroxamic Acids; Lung Neoplasms; Prognosis; Promoter Regions, Genetic; Tumor Suppressor Protein p53; Vorinostat | 2008 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Induction of MAGE-3 expression in lung and esophageal cancer cells.
Topics: Adenocarcinoma; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antigens, Neoplasm; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Depsipeptides; DNA Modification Methylases; Enzyme Inhibitors; Esophageal Neoplasms; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lung Neoplasms; Melanoma; Neoplasm Proteins; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2001 |
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
Topics: Acid Anhydride Hydrolases; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Blotting, Northern; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Protein Biosynthesis; Proteins; RNA, Messenger | 2001 |
Diminished expression of S100A2, a putative tumor suppressor, at early stage of human lung carcinogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Biomarkers, Tumor; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Line, Transformed; Cell Transformation, Neoplastic; Chemotactic Factors; Decitabine; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Rats; RNA, Neoplasm; S100 Proteins; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Decitabine; Disease-Free Survival; DNA Methylation; DNA Modification Methylases; Female; Humans; Lung Neoplasms; Male; Middle Aged | 2001 |
Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Northern; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Phosphoric Monoester Hydrolases; Promoter Regions, Genetic; PTEN Phosphohydrolase; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.
Topics: Animals; Azacitidine; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Chromosomes, Human, Pair 3; CpG Islands; Decitabine; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Kidney Neoplasms; Loss of Heterozygosity; Lung Neoplasms; Mutation, Missense; Nerve Tissue Proteins; Promoter Regions, Genetic; Receptors, Immunologic; Roundabout Proteins; Sequence Homology, Nucleic Acid; Tumor Cells, Cultured | 2002 |
Fetal hemoglobin gene activation in a phase II study of 5,6-dihydro-5-azacytidine for bronchogenic carcinoma.
Topics: Adult; Antibodies, Antinuclear; Azacitidine; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Fetal Hemoglobin; Gene Expression Regulation; Globins; Heart Diseases; Humans; Lung Neoplasms; Neoplasm Proteins; Pain; Transcriptional Activation | 1987 |
Phase II study of 5,6-dihydro-5-azacytidine in extensive, untreated non-small cell lung cancer.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged | 1987 |