azacitidine has been researched along with Breast Cancer in 248 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (2.42) | 18.7374 |
1990's | 14 (5.65) | 18.2507 |
2000's | 98 (39.52) | 29.6817 |
2010's | 126 (50.81) | 24.3611 |
2020's | 4 (1.61) | 2.80 |
Authors | Studies |
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Gun, M; Hong, XY; Wang, Q | 1 |
Bear, HD; Camarena, C; Conrad, DH; Damle, SR; Gilmer, JS; Graham, LJ; Luker, AJ; Martin, RK; Smith, TM; Zellner, MP | 1 |
Lu, A; Ring, BZ; Su, L; Tanaka, Y; Wang, W; Wang-Renault, SF; Weng, J | 1 |
Andrews, C; Maze, D; Murphy, T; Sibai, H | 1 |
Ahmad, M; Akhtar Ali, M; Ali, M; Anjum, RS; Aslam, B; Farooq, K; Hassan, U; Javed, M; Munir, T; Mustafa, T; Mutahir, Z; Shahzad, N; Shakoori, AR; Tasneem, F; Umer, M | 1 |
Chang, YW; Singh, KP | 1 |
Khan, GN; Kim, EJ; Lee, SH; Shin, TS | 1 |
Acun, T; Doberstein, N; Gemoll, T; Habermann, JK; Oztas, E; Ried, T; Thorns, C | 1 |
Chen, Y; Li, Z; Luo, D; Tian, W; Zhang, X | 1 |
Baura, VA; Biembengut, IV; Chequin, A; Costa, FF; de O Pedrosa, F; de Souza, EM; Klassen, G; Klassen, LMB; Manica, GCM; Ramos, EAS; Toledo, MB | 1 |
Balko, JM; Gonzalez-Ericsson, PI; Li, H; Liu, F; Luo, N; Manning, HC; Nickels, ML; Nixon, MJ; Opalenik, SR; Sanchez, V; Sanders, ME; Tantawy, MN; Zahnow, CA | 1 |
Abu-Irmaileh, B; Al-Majawleh, M; Hamadneh, L; Hasan, M; Jarrar, Y; Shraim, S | 1 |
Bharti, R; Das, AK; Dey, G; Mandal, M | 1 |
Curtis, SA; Folkers, A; Medoff, E; Mixon, R; Shallis, RM; Xu, ML; Zeidan, AM | 1 |
Chen, Y; Cui, X; Hu, H; Jiao, Y; Li, S; Lin, L; Lv, X; Song, E; Wang, M; Yao, H; Yu, F | 1 |
Arafa, M; Balasubramanian, S; Brown, NJ; Higham, SE; Perunovic, B; Rehman, I | 1 |
Bendinelli, P; Desiderio, MA; Locatelli, A; Maroni, P; Matteucci, E | 1 |
Charalambous, C; Constantinou, AI; Papageorgis, P; Pitta, CA | 1 |
Brown, K; Gillespie, KM; Holly, JM; Jarrett, C; Perks, CM; Zeng, L | 1 |
Brenner, C; Cryderman, DE; Fagan, RL; Kopelovich, L; Wallrath, LL | 1 |
Boffelli, D; Coppé, JP; Di Noia, JM; Heo, SJ; Lee, EL; Martin, DI; Muñoz, DP; Takayama, S | 1 |
Ge, YL; Han, LL; Hou, L; Lin, DL; Ma, ZL; Wu, L; Zhou, MJ | 1 |
Mahajan, N; Sabherwal, Y; Zhang, M | 1 |
Anastasiadis, PZ; Andorfer, CA; Borges, S; Döppler, H; Geiger, XJ; Perez, EA; Storz, P; Sun, Z; Thompson, E | 1 |
Chik, F; Machnes, Z; Szyf, M | 1 |
Al-Nakhle, H; Bell, SM; Burns, PA; Cummings, M; Hanby, AM; Hughes, TA; Lane, S; Parker, MD; Smith, L; Speirs, V | 1 |
Azevedo-Pouly, AC; Elgamal, OA; Gusev, Y; Jiang, J; Park, JK; Roopra, A; Schmittgen, TD | 1 |
Ang, WT; Ho, GH; Koh, QM; Koong, HN; Lin, VC; Sivaramakrishnan, G; Sun, Y | 1 |
Anderton, DL; Arcaro, KF; Lee, MP; Pentecost, BT; Williams, KE | 1 |
Jazirehi, AR; Torres-Collado, AX | 1 |
Geng, CZ; Hou, SY; Liu, WH; Lü, WH; Sang, MX; Shan, BE; Xu, YY | 1 |
Clarke, K; Qin, W; Sauter, ER; Weiland, T; Zhang, K | 1 |
Dai, Q; Gu, Y; Guo, S; Pan, S; Yu, Y; Zhang, W; Zhao, F | 1 |
Brglez, V; Lambeau, G; Petan, T; Pucer, A; Pungerčar, J | 1 |
Borges, S; Döppler, HR; Storz, P | 1 |
Al-Rayyan, N; Cheng, A; Elbedewy, A; Ivanova, MM; Klinge, CM; Litchfield, LM; Radde, BN | 1 |
Bai, SY; Jiao, F; Ma, Y; Wang, J; Wang, X; Yan, ZH; Yu, Y; Yue, Z | 1 |
Chang, HW; Chen, CY; Hou, MF; Huang, CJ; Hung, TW; Tseng, CN; Wang, HC; Yuan, SS | 1 |
Huang, S; Luo, M; Ning, Q; Qin, Y; Shao, S; Yuan, N; Zhang, X; Zhao, X; Zuo, X | 1 |
Motevalli, A; Roberts, T; Slijepcevic, P; Virmouni, SA; Yasaei, H | 1 |
Du, M; Su, XM; Xing, YJ; Zhang, T | 1 |
Fiegl, H; Fleischer, M; Hollmann, MW; Lirk, P; Weber, NC | 1 |
Abba, MC; Cattaneo, ER; Coleman, RA; Garcia-Fabiani, MB; Gonzalez-Baro, MR; Lacunza, E; Montanaro, MA; Pellon-Maison, M; Quiroga, IY; Soler-Gerino, MC | 1 |
Capobianco, E; Cinti, C; El Baroudi, M; La Sala, D | 1 |
Arakelian, A; Bhattacharya, B; Cheishvili, D; Chik, F; Hallett, M; Li, CC; Rabbani, SA; Suderman, M; Szyf, M | 1 |
Braun-Prado, K; Camargo, AA; Chequin, A; Costa, ET; Costa, FF; Klassen, G; Klassen, LM; Manica, GC; Pedrosa, Fde O; Pereira, IT; Ramos, EA; Souza, EM | 1 |
Barrio-Real, L; Benedetti, LG; Cho, S; Engel, N; Kazanietz, MG; Sukumar, S; Tu, Y | 1 |
Calvo, F; Daunay, A; Djaafri, I; Fauvel, F; Idbaih, A; Janin, A; Khayati, F; Lebbé, C; Menashi, S; Mourah, S; Podgorniak, MP; Sadoux, A; Setterblad, N; Soulier, J; Teixeira, L; Tost, J | 1 |
Katagiri, T; Lo, PH; Matsuda, K; Nakamura, Y; Tanikawa, C | 1 |
Du, XJ; Jun, W; Li, SY; Liu, Y; Shen, S; Sun, R; Wang, HX; Zhu, YH | 1 |
Fan, JJ; Gao, Y; Li, HY; Li, Y; Ma, DM; Mai, L; Song, FZ; Wu, JY; Zeng, F; Zhang, J | 1 |
Heldin, CH; Idås, O; Kahata, K; Moustakas, A; Tan, EJ; Thuault, S | 1 |
Mahalingaiah, PK; Singh, KP; Treas, JN; Tyagi, T | 1 |
ChuanYi, Z; Hui, L; Hui, Z; Wenting, Y; XuQun, H; Yiling, C | 1 |
Borcherding, NC; Mahauad-Fernandez, WD; Okeoma, CM; Zhang, W | 1 |
Chang, CH; Chang, SC; Chen, CY; Chuu, CP; King, KL; Kung, HJ; Shiah, SG; Su, LC; Wen, HC | 1 |
Jaksic, O; Kusec, R; Lasan-Trcic, R; Lucijanic, M; Pejsa, V; Stoos-Veic, T | 1 |
Ditzel, HJ; Gjerstorff, MF; Maheswaran, E; Pedersen, CB | 1 |
Berdasco, M; Blanco-Luquin, I; Coca, V; Cordoba, A; De La Cruz, S; Escors, D; Guerrero-Setas, D; Ibañez, B; Illarramendi, JJ; Jauregui, I; Kochan, G; Lera, JM; Liechtenstein, T; Perez-Janices, N; Torrea, N; Vicente-Garcia, F | 1 |
Mei, M; Tian, WP; Zhang, YY | 1 |
Gopinadh, J; Klar, AS; Kleber, S; Renner, C; Wadle, A | 1 |
Bendinelli, P; Desiderio, MA; Disanza, A; Maroni, P; Matteucci, E | 1 |
Ema, A; Enomoto, T; Katoh, H; Kikuchi, M; Kojo, K; Kosaka, Y; Minatani, N; Sawanobori, M; Sengoku, N; Tanino, H; Ushiku, H; Waraya, M; Watanabe, M; Yamashita, K | 1 |
Argyle, DJ; Coonrod, SA; Curtis, TM; Harman, RM; Van de Walle, GR | 1 |
Kalayoğlu Beşışık, S; Turan Erkek, E | 1 |
Borikun, TV; Chekhun, VF; Lukianova, NY | 1 |
Iwaisako, K; Kawashima, M; Kawata, Y; Kurebayashi, J; Nishimura, T; Noda, M; Shi, G; Toi, M; Yoshida, Y; Yoshikawa, K; Yuki, K | 1 |
Barwick, BG; Bell, JS; Dwivedi, B; Kagey, JD; Kowalski, J; McCabe, MT; Vertino, PM | 1 |
Kong, X; Liu, A; Liu, J; Liu, Y; Su, Y; Sun, P; Wang, X; You, D; Yuan, L; Zhang, D; Zhang, X | 1 |
Choi, JH; Ganapathy, V; Kolhe, R; Lokeshwar, BL; Manicassamy, S; Mariappan, G; Pathania, R; Prasad, PD; Ramachandran, S; Sharma, S; Shi, H; Thakur, P; Thangaraju, M | 1 |
Baek, A; Bear, HD; Damle, SR; Graham, LJ; Manjili, MH; Payne, KK; Terracina, KP | 1 |
Guo, H; Guo, Y; Huang, T; Liu, C; Liu, Z; Peng, G; Wang, L; Wang, S; Yin, X; Yu, P; Yusufu, M; Zhao, X | 1 |
Dang, Q; Dong, B; Guo, Y; Jin, X; Li, Y; Lin, D; Liu, Y; Lu, Y; Quan, C; Ruan, Y; Song, P; Xie, Y; Yang, M; Zhao, S | 1 |
Fan, Y; Feng, Y; Kelly, K; Li, C; Li, L; Mu, J; Oberst, M; Peng, W; Ren, G; Tao, Q; Xiang, T; Ying, Y | 1 |
Bendinelli, P; Desiderio, MA; Maroni, P; Matteucci, E | 1 |
Ansari, KI; Chen, MY; Choy, C; Jandial, R; Levy, DM | 1 |
Gupta, PS; Limaye, AM; Manjegowda, MC | 1 |
Brown, KD; Demircan, B; Dyer, LM; Gerace, M; Lobenhofer, EK; Robertson, KD | 1 |
Bigl, M; Eschrich, K; Horn, LC; Jandrig, B | 1 |
Alonso, MA; Horne, HN; Lee, PS; Marks, JR; Murphy, SK; Olson, JA | 1 |
Csiszar, K; Fong, KS; Fong, SF; Hollosi, P; Yakushiji, JK | 1 |
Epstein, RJ; Xiong, J | 1 |
Brooke, DG; Datta, J; Denny, WA; Gamage, SA; Ghoshal, K; Jacob, ST; Phiasivongsa, P; Redkar, S | 1 |
Jagodzinski, PP; Piotrowska, H | 1 |
Chen, Y; Domann, FE; Hitchler, MJ; Weigel, RJ; Woodfield, GW | 1 |
Billam, M; Davidson, NE; Sobolewski, MD | 1 |
An, CH; Cho, HJ; Kang, WK; Kim, JI; Kim, JS; Kim, KH; Kim, SY; Oh, ST | 1 |
Chen, Y; Collins, C; Huo, D; Nwachukwu, C; Olopade, OI; Rowell, J; Slamon, DJ; Xu, J | 1 |
Chen, Y; Jiang, R; Qiu, H; Xiong, H; Zhuang, L | 1 |
Cruickshanks, HA; Tufarelli, C | 1 |
Ali, IY; Gupta, C; Gupta, J; Tikoo, K | 1 |
Chen, L; Fu, DY; Huang, W; Shao, ZM; Shen, ZZ; Wang, BL; Wang, ZM; Yang, WT | 1 |
Chin, K; Chua, CL; Eu, KW; Gray, JW; Ho, YM; Hong, GS; Kuo, WL; Lee, AS; Lie, DK; Ong, DC; Rudduck, C; Seow-Choen, F; Tan, PH; Wong, CY | 1 |
Jagodzinski, PP; Lianeri, M; Lutkowska, A; Pietkiewicz, PP | 1 |
Brown, I; Kastl, L; Schofield, AC | 2 |
Ashida, M; Fujikane, T; Hirata, K; Kai, M; Maruyama, R; Nishidate, T; Nishikawa, N; Nojima, M; Ohe-Toyota, M; Ohmura, T; Sasaki, Y; Suzuki, H; Tokino, T; Toyota, M | 1 |
Chan, E; Marquez, VE; Sun, F; Wu, Z; Yang, X; Yu, Q | 1 |
Chai, XJ; Ge, YJ; Luan, J; Qin, Y; Yang, WL; Zhang, YC | 1 |
Jang, YK; Park, SH; Yu, SE | 1 |
Chaudhary, PM; Matta, H; Punj, V | 1 |
An, SX; Chen, XL; Cui, W; Li, BL; Lu, YY; Mi, XY; Song, M; Wang, EH; Wang, LH; Wen, YY; Xu, M; Zhao, J | 1 |
Cheng, SY; Fu, J; Hu, J; Qu, Z; Xiao, G; Yan, P | 1 |
Bazarov, AV; Hines, WC; Mukhopadhyay, R; Yaswen, P | 1 |
Fackler, M; Gabrielson, E; Marik, R; Stearns, V; Sukumar, S; Umbricht, CB; Zeiger, MA | 1 |
Mirza, S; Pandya, P; Ralhan, R; Sharma, G | 1 |
Chang, HL; Huang, YW; Lin, YC; Liu, S; Shu, ST; Sugimoto, Y; Wang, LS; Yan, P; Ye, W | 1 |
Inoue, J; Ishida, T; Ito, T; Semba, K; Shimizu, T; Watanabe, S; Yamaguchi, N; Yamamoto, M | 1 |
Asa, SL; Ezzat, S; Zheng, L; Zhu, X | 1 |
Ahn, SG; Kang, KW; Kim, HS; Kim, SK; Kim, TH; Lee, KY; Lim, SC; Phuong, NT; Yoon, JH | 1 |
Jang, YK; Park, SH; Shin, JE | 1 |
Bast, RC; Feng, Y; Huan, J; Jia, L; Jin, H; Lu, Z; Yao, M; Yu, Y; Zhao, N; Zou, CF | 1 |
Ding, Q; Ding, YB; Liu, XA; Liu, YX; Shi, JP; Wang, S; Xia, JG; Xia, TS; Zhao, Y | 1 |
Hattori, N; Kikuyama, M; Okochi-Takada, E; Ushijima, T; Wakabayashi, M; Yamashita, S | 1 |
Li, W; Matsumura, F; Vogel, CF; Wong, P; Wu, D | 1 |
Bhattacharyya, B; Hallett, M; Han, ZG; Huang, J; Stefanska, B; Suderman, M; Szyf, M | 1 |
Byrne, DJ; Dobrovic, A; Fox, SB; Huang, KT; Mikeska, T; Takano, EA | 1 |
Bouizar, Z; Busato, F; Dupont, JM; Hamzaoui, H; Mourah, S; Neyret, A; Tost, J | 1 |
Kim, JH; Kim, SJ; Kim, TW | 1 |
Briones, V; Geiman, TM; Liu, S; Muegge, K; Tao, Y | 1 |
Ari, F; Colling, C; Dere, E; Honert, K; Kiechle, M; Krüger, A; Napieralski, R; Schmitt, M; Ulukaya, E | 1 |
Avraham, A; Bose, S; Evron, E; Gal-Yam, EN; Israeli, S; Kaufman, B; Rubinek, T; Shulman, M; Wolf, I; Zundelevich, A | 1 |
Artemov, D; Carraway, H; Domek, J; Kato, Y; Kimble, B; Kowalski, J; Lisok, A; Raman, V; van der Groep, P; van Diest, P; Vesuna, F | 1 |
Barekati, Z; Bitzer, J; Grussenmeyer, T; Hartmann, N; Jenoe, P; Kohler, C; Lefkovits, I; Letzkus, M; Moes, S; Radpour, R; Schumacher, MM; Staedtler, F; Zhong, XY | 1 |
Gao, W; Singh, KP; Treas, J; Tyagi, T | 1 |
Cavalli, LR; da Costa Prando, E; Rainho, CA | 1 |
Kucerova, L; Matuskova, M; Poturnajova, M; Tyciakova, S | 1 |
Ahuja, N; Baylin, SB; Beaty, R; Brock, MV; Cai, Y; Feller-Kopman, D; Harbom, KM; Harris, J; Issa, JP; Jang, YY; Li, H; Lin, YC; Matsui, W; Minn, I; Pappou, E; Rassool, FV; Robert, C; Sharkis, SJ; Shin, JJ; Stearns, V; Tsai, HC; Van Neste, L; Welm, AL; Yarmus, LB; Yen, RW; Zahnow, CA | 1 |
Chen, H; Jin, F; Liu, C; Mao, XY; Wang, H; Wei, J; Yao, F; Zheng, HC | 1 |
Ernberg, I; Grigorieva, EV; Gubanova, NV; Haraldson, K; Kashuba, VI; Kharchenko, OA; Kondratov, AG; Kutsenko, OS; Mostovich, LA; Prudnikova, TY; Vavilov, PV; Zabarovsky, ER | 1 |
Dutkowski, C; Farrow, L; Fiegl, H; Gee, JM; McClelland, RA; McCloy, RA; Musgrove, EA; Nicholson, RI; Stone, A; Sutherland, RL; Valdés-Mora, F | 1 |
Labhasetwar, V; Lu, S; Peetla, C; Vijayaraghavalu, S | 1 |
Colon-Otero, G; Cooper, SJ; Copland, JA; Grebe, SK; Kang, KH; Marlow, LA; Menefee, ME; Perez, EA; Tun, HW; von Roemeling, CA | 1 |
Dahlman-Wright, K; Gustafsson, JÅ; Putnik, M; Zhao, C | 1 |
Atadja, P; Feng, X; Ganapathy, A; Kumar Mishra, M; Morris, D; Qiao Shi, Z; Riabowol, K; Thakur, S | 1 |
Chen, Y; Dai, F; Li, G; Li, R; Pan, X; Wang, L; Yang, J; Zhang, Y | 1 |
Abe, E; Clyne, CD; Knower, KC; Miki, Y; Sasano, H; Simpson, ER; Suzuki, K; Takagi, K; To, SQ; Yang, Y | 1 |
Godwin, AK; Guo, S; Liu, M | 1 |
Bogachek, M; Cyr, AR; Domann, FE; Kulak, MV; Li, T; Price, DH; Spanheimer, PM; Weigel, RJ; Woodfield, GW | 1 |
Chae, H; Evans, J; Gray, JW; Gu, F; Huang, RL; Huang, TM; Huang, YW; Kim, S; Lai, HC; Lin, H; Liu, Y; Miller, D; Nephew, KP; Pilrose, J; Rao, X; Rhee, JK; Yan, P | 1 |
Baraty, C; Bianco, C; Castro, NP; Gonzales, M; Held, N; Karasawa, H; Rangel, MC; Rollman, K; Salomon, DS; Strizzi, L | 1 |
Cheriyath, V; Dermawan, JK; Labhasetwar, V; Vijayaraghavalu, S | 1 |
Ball, GR; Ellis, IO; Gritzapis, AD; Hughes, DC; Laversin, SA; Li, G; McArdle, SE; Miles, AK; Missitzis, I; Phatak, VM; Powe, DG; Rees, RC | 1 |
Labhasetwar, V; Vijayaraghavalu, S | 1 |
Chen, H; Hardy, TM; Li, Y; Meeran, SM; Patel, SN; Tollefsbol, TO | 1 |
Gagnon, J; Momparler, RL; Primeau, M | 1 |
Godwin, AK; Gupta, A; Liu, J; Lu, A; Vanderveer, L | 1 |
Gagnon, J; Hurtubise, A; Momparler, RL; Primeau, M; Shaker, S | 1 |
Durkin, ME; Popescu, NC; Yuan, BZ | 1 |
Acuña, C; Chavez, A; Dueñas-Gonzalez, A; Lizano, M; Mariscal, I; Perez-Cardenas, E; Salazar, AM; Segura-Pacheco, B; Taja-Chayeb, L; Trejo-Becerril, C | 1 |
Domann, FE; Futscher, BW; Junk, DJ; Munoz-Rodriguez, JL; Oshiro, MM; Watts, GS; Wozniak, RJ | 1 |
Bates, PA; Brown, I; Contreras-Moreira, B; Gabra, H; Li, L; Massie, CE; Miller, EP; Miller, J; Rabiasz, GJ; Scott, D; Sellar, GC; Smyth, JF; Stronach, EA; Watt, KP; Williams, AR | 1 |
Andreeff, M; Bast, RC; Fujii, S; Hu, W; Issa, JP; Kadota, M; Luo, RZ; Oshimura, M; Pan, Y; Sahin, AA; Wang, L; Yu, Y; Yuan, J | 1 |
Facchinetti, F; Mezzanzanica, D; Modena, P; Pilotti, S; Radice, MT; Sozzi, G; Testi, MA | 1 |
Baylin, SB; Belinsky, SA; Crume, KP; Esteller, M; Grimes, MJ; Joste, N; Palmisano, WA; Toyota, M; Winters, SA | 1 |
Euhus, DM; Gazdar, AF; Heda, S; Lewis, C; Minna, JD; Rathi, A; Roth, JA; Sugio, K; Takahashi, T; Tonk, V; Virmani, A | 1 |
Bell, SM; Carder, PJ; Hanby, AM; Horgan, K; Lane, S; Lansdown, MR; Markham, AF; Munot, K; Parkes, AT; Skliris, GP; Speirs, V | 1 |
Davidson, NE; Keen, JC; Mack, KM; Pettit, C; Sharma, D; Smith, D; Yan, L | 1 |
Erson, AE; Petty, EM | 1 |
David, GL; De Marzo, AM; Kumar, A; Lin, X; Marchi, VL; Nelson, WG; Yegnasubramanian, S | 1 |
Hurtubise, A; Momparler, RL | 2 |
Doihara, H; Dote, H; Shimizu, N; Teramoto, A; Toyooka, S; Tsukuda, K; Yano, M | 1 |
Butcher, DT; Haines, TR; Rodenhiser, DI; Sadikovic, B | 1 |
Sharma, D; Vertino, PM | 1 |
Dai, JL; Liu, H; Sahin, A; Yuan, Y | 1 |
Chen, JX; Cui, XY; Fu, PF; Wang, T | 1 |
Davidson, NE; Garrett-Mayer, E; Herman, JG; Keen, JC; Mack, KM; Manning, J; Pettit, C | 1 |
Arnold, W; Deutschmann, N; Klebig, C; Pacyna-Gengelbach, M; Petersen, I; Scherneck, S; Seitz, S | 1 |
Guo, Y; Huper, G; Marks, JR; Murphy, SK; Olson, JA; Wang, W | 1 |
Beaulieu, N; Blum, J; Davidson, NE; Macleod, AR; Sharma, D; Yang, X | 1 |
Gudas, LJ; Mongan, NP | 1 |
Antsaklis, AI; Baxevanis, CN; Gritzapis, AD; Ioannidis, P; Kavalakis, GJ; Mahaira, LG; Papamichail, M; Perez, SA; Sotiropoulou, PA | 1 |
Bakin, AV; Li, X; Quan, L; Safina, AF; Sossey-Alaoui, K; Stourman, NV; Varga, AE; Zheng, Q | 1 |
Albergaria, A; Jerónimo, C; Milanezi, F; Oliveira, JT; Paredes, J; Schmitt, FC | 1 |
Raut, CG; Somasundaram, K; Wajapeyee, N | 1 |
Chan, TK; Chan, V; Cheng, CK; Chow, LW; Loo, WT | 1 |
Das, S; Dignam, J; Fackenthal, J; Grushko, TA; Hagos, F; Nanda, R; Olopade, OI; Sveen, L; Tretiakova, M; Wei, M; Xu, J | 1 |
DeWille, JW; Sivko, GS; Tang, D | 1 |
Argani, P; D'Costa, A; Fackler, MJ; Garrett-Mayer, E; Lo, PK; Mehrotra, J; Sukumar, S | 1 |
Jiang, J; Peng, ZH; Tang, B | 1 |
Banwell, CM; Campbell, MJ; Colston, KW; Guy, M; MacCartney, DP; Mansi, J; Miles, AE; O'Neill, LP; Stewart, PM; Turner, BM; Uskokovic, MR | 1 |
Amberger, A; Eichmann, C; Fiegl, H; Fong, D; Gastl, G; Grünewald, K; Haun, M; Margreiter, R; Millinger, S; Obrist, P; Parson, W; Spizzo, G | 1 |
Berenguer, J; Borczuk, AC; Hei, TK; Powell, CA; Shao, G; Zhao, Y | 1 |
Davidson, NE; Saxena, NK; Sharma, D; Vertino, PM | 1 |
Pampalakis, G; Sotiropoulou, G | 1 |
Diamandis, EP; Pampalakis, G; Sotiropoulou, G | 1 |
Bhalla, KN; Huang, C; Inoue, M; Ito, K; Ito, Y; Ko, TK; Lau, QC; Liu, Q; Loh, M; Putti, TC; Raja, E; Salto-Tellez, M; Sukumar, S; Zhu, T | 1 |
Hongmei, L; Xiaoyan, X; Yuecheng, Y | 1 |
Coleman, WB; Jones, WD; Rivenbark, AG | 1 |
Fabianowska-Majewska, K; Krawczyk, B | 1 |
Calin, GA; Croce, CM; Di Leva, G; Godwin, AK; Iliopoulos, D; Negrini, M; Nicoloso, MS; Petrocca, F; Qin, HR; Shimizu, M; Trapasso, F; Vecchione, A; Wojcik, SE; Yendamuri, S | 1 |
Euhus, DM; Fong, KM; Gao, B; Gazdar, AF; Gerald, W; Girard, L; Jiang, A; Kim, YH; Lam, CL; Lewis, CM; Minna, JD; Nanda, R; Olopade, OI; Perou, CM; Pollack, JR; Sato, M; Shames, DS; Shay, JW; Shivapurkar, N; Shyr, Y; Wong, M | 1 |
Fujisawa, T; Gazdar, AF; Iizasa, T; Minna, JD; Shames, DS; Shigematsu, H; Shivapurkar, N; Sunaga, N; Suzuki, M; Takahashi, T | 1 |
Druck, T; Fabbri, M; Han, SY; Huebner, K; Iliopoulos, D; Qin, HR | 1 |
Berger, W; Depisch, D; Filipits, M; Geradts, J; Heller, G; Kandioler, D; Markis-Ritzinger, EM; Newsham, I; Pirker, R; Stiglbauer, W; Ziegler, B; Zielinski, CC; Zöchbauer-Müller, S | 1 |
Tainsky, MA; Wu, GS; Xu, J; Zhou, JY | 1 |
Díaz-Montero, CM; Estecio, M; Issa, JP; Mao, L; Montero, AJ; Shen, L; Youssef, EM | 1 |
Betz, B; Ehrentraut, D; Felsberg, J; Hampl, JA; Hellmich, M; Köhler, J; Mikeska, T; Niederacher, D; Pietsch, T; Röhn, G; Schmutzler, RK; Versmold, B; Waha, A | 1 |
Di, GH; Fan, J; Hou, YF; Lei, W; Li, DQ; Lu, JS; Shao, ZM; Shen, ZZ; Wu, FY; Wu, J; Yin, WJ | 1 |
Fan, QX; Li, LW; Lu, SH; Wang, LX; Wang, R; Wang, RL; Zhao, PR | 1 |
Bronner, C; Giordano, A; Gregorio, V; Macaluso, M; Montanari, M; Noto, PB | 1 |
Keen, JC; Obajimi, O; Pryzbylkowski, P | 1 |
Christgen, M; Hasemeier, B; Kreipe, H; Länger, F; Lehmann, U; Müller, M; Römermann, D | 1 |
Fabianowska-Majewska, K; Krawczyk, B; Rudnicka, K | 1 |
Chen, J; Huang, T; Liu, K; Wang, G; Zhang, B | 1 |
Coleman, WB; Jones, WD; Rivenbark, AG; Roll, JD | 1 |
Di, GH; Fan, J; Lu, JS; Shao, ZM; Shen, ZZ; Wang, L; Wu, FY; Wu, J; Yin, WJ | 1 |
Ethier, SP; Hanifi-Moghaddam, P; Hollestelle, A; Klijn, JG; Merajver, SD; Schutte, M; van den Ouweland, A; Wasielewski, M | 1 |
Hancock, MC; Smith, HS | 1 |
Dekker, A; Dorssers, LC; Foekens, JA; van Agthoven, T; van Agthoven, TL | 1 |
Baylin, SB; Davidson, NE; Ferguson, AT; Lapidus, RG | 1 |
Dorssers, LC; Foekens, JA; van Agthoven, T; van Agthoven, TL | 1 |
Alpert, L; Huynh, H; Pollak, M | 1 |
Akiyoshi, T; Fujie, T; Mori, M; Sugimachi, K; Ueo, H | 1 |
Fearon, ER; Ji, X; Rimm, DL; Woodard, AS | 1 |
Baylin, SB; Davidson, NE; Ferguson, AT; Muller, MT; Spitzner, JR; Vertino, PM | 1 |
Jhaveri, MS; Morrow, CS | 1 |
Ammanamanchi, S; Brattain, MG; Kim, SJ; Sun, LZ | 1 |
Rabbani, SA; Xing, RH | 1 |
Bovenzi, V; Côte, S; Lê, NL; Momparler, LF; Momparler, RL; Sinnett, D | 1 |
Ferguson, AT; Orlandi, R; Sacchi, N; Sirchia, SM; Sironi, E; Subramanyan, S; Sukumar, S | 1 |
Chan, TA; Evron, E; Ferguson, AT; Futreal, PA; Hermeking, H; Lambers, AR; Marks, JR; Pandita, TK; Stampfer, MR; Sukumar, S; Umbricht, CB | 1 |
Benchaïb, M; Billard, LM; Dante, R; Frappart, L; Guérin, JF; Lenoir, GM; Magdinier, F; Wittmann, G | 1 |
Arapshian, A; Kuppumbatti, YS; Mira-y-Lopez, R | 1 |
Ammanamanchi, S; Brattain, MG; Periyasamy, S; Tillekeratne, MP | 1 |
Kakudo, K; Mori, I; Nakamura, M; Nakamura, Y; Sakurai, T; Shan, L; Suzuma, T; Tamaki, T; Umemura, T; Utsunomiya, H; Yang, Q; Yoshimura, G | 1 |
Clare, SE; Clark, G; Elkahloun, AG; Hartsough, MT; Mair, M; Osborne, CK; Sgroi, D; Steeg, PS | 1 |
Ashfaq, R; Fong, KM; Gazdar, AF; Geradts, J; Lam, S; Maitra, A; Milchgrub, S; Minna, JD; Virmani, AK; Zöchbauer-Müller, S | 1 |
Ammanamanchi, S; Brattain, MG | 1 |
Bovenzi, V; Momparler, RL | 1 |
Dzhandzhugazyan, KN; Guldberg, P; Kirkin, AF; Worm, J | 1 |
Ahlborn, TE; Gupta, A; Li, C; Liu, J; Lu, A; Ma, Y; Shi, EY | 1 |
Davidson, NE; Ferguson, AT; Herman, JG; Nelson, WG; Phillips, DL; Yang, X | 1 |
Band, V; Dhar, S; Dimri, G; Evron, E; Goyal, J; Li, B; Sukumar, S; Wazer, DE | 1 |
Filmus, J; Ladeda, V; Xiang, YY | 1 |
Crichton, DN; Hupp, TR; Kernohan, N; McDowell, HE; Nicoll, G; Thompson, AM | 1 |
Bianco, T; Dobrovic, A; Tan, LW | 1 |
Bharadwaj, S; Prasad, GL | 1 |
Dallol, A; Forgacs, E; Kishida, T; Latif, F; Maher, ER; Martinez, A; Minna, JD; Rabbitts, P; Sekido, Y; Walker, R | 1 |
Muggia, FM; Slavik, M; Von Hoff, DD | 1 |
Keyomarsi, K; Lee, SW; Sager, R; Swisshelm, K; Tomasetto, C | 1 |
Esparza, L; Holmes, FA; Hortobagyi, GN; Theriault, RL; Walters, RS | 1 |
Carroll, AR; Kahl, LP; Read, NG; Rhodes, P; Wood, J | 1 |
Golovkina, TV; Litvinov, SV | 1 |
Gregory, P; Wang, N | 1 |
Kaysen, J; Kufe, D; Spriggs, D | 1 |
Bruntsch, U; Gallmeier, WM; Osieka, R; Schmidt, CG; Seeber, S | 1 |
5 review(s) available for azacitidine and Breast Cancer
Article | Year |
---|---|
Combination treatment with CPX-351 and midostaurin in patients with secondary acute myeloid leukaemia that are FLT3 mutated: three cases and review of literature.
Topics: Aged; Allografts; Anemia, Refractory, with Excess of Blasts; Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials, Phase III as Topic; Cytarabine; Daunorubicin; Fatal Outcome; Female; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Liposomes; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm, Residual; Neoplasms, Radiation-Induced; Oncogene Proteins, Fusion; Peripheral Blood Stem Cell Transplantation; Point Mutation; Protein Kinase Inhibitors; Pyrazines; Remission Induction; Salvage Therapy; Staurosporine; Sulfonamides | 2020 |
Conviction in the face of affliction: a case series of Jehovah's Witnesses with myeloid malignancies.
Topics: Aged; Anemia, Macrocytic; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Azacitidine; Blood Transfusion; Breast Neoplasms; Female; Humans; Hydroxyurea; Isocitrate Dehydrogenase; Jehovah's Witnesses; Leukemia, Myeloid, Acute; Male; Myeloproliferative Disorders; Neoplasms, Second Primary; Treatment Refusal | 2018 |
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells.
Topics: Antigens, CD; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Computational Biology; CpG Islands; Databases, Nucleic Acid; DNA Methylation; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Promoter Regions, Genetic; RNA, Messenger | 2015 |
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Breast Neoplasms; Cats; Cell Line; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Neoplasm Proteins; Promoter Regions, Genetic; Proof of Concept Study; Species Specificity; Tumor Cells, Cultured | 2016 |
5-Azacytidine. A new anticancer drug with effectiveness in acute myelogenous leukemia.
Topics: Animals; Azacitidine; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Europe; Female; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Liver; Nausea; Neoplasms, Experimental; Neuromuscular Diseases; RNA, Messenger; United States; Vomiting | 1976 |
1 trial(s) available for azacitidine and Breast Cancer
Article | Year |
---|---|
Phase II trial of fazarabine (ARA-AC, arabinosyl-5-azacytosine) in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Carcinoma; Drug Evaluation; Female; Humans; Middle Aged | 1992 |
242 other study(ies) available for azacitidine and Breast Cancer
Article | Year |
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Induced Tamoxifen Resistance is Mediated by Increased Methylation of E-Cadherin in Estrogen Receptor-Expressing Breast Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Breast Neoplasms; Cadherins; Cell Movement; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Nuclear Proteins; Receptors, Estrogen; Tamoxifen; Twist-Related Protein 1 | 2019 |
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
Topics: Animals; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; DNA Modification Methylases; Female; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Myelopoiesis; T-Lymphocytes, Cytotoxic | 2020 |
5-Aza-2'-deoxycytidine advances the epithelial-mesenchymal transition of breast cancer cells by demethylating
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans | 2020 |
SHISA3, an antagonist of the Wnt/β-catenin signaling, is epigenetically silenced and its ectopic expression suppresses growth in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; RNA, Messenger; Wnt Signaling Pathway | 2020 |
Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Decitabine; DNA Methylation; Doxorubicin; Drug Synergism; Epigenesis, Genetic; Estradiol; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; MCF-7 Cells | 2017 |
Azacytidine-induced Chemosensitivity to Doxorubicin in Human Breast Cancer MCF7 Cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Azacitidine; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Cell Proliferation; Cell Survival; Doxorubicin; Female; Humans; MCF-7 Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2017 |
HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer.
Topics: Adult; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cohort Studies; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; HSP40 Heat-Shock Proteins; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Precision Medicine; RNA, Messenger | 2017 |
Demethylation of miR-495 inhibits cell proliferation, migration and promotes apoptosis by targeting STAT-3 in breast cancer.
Topics: Apoptosis; Azacitidine; Breast Neoplasms; Cell Movement; Cell Proliferation; Demethylation; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; MicroRNAs; Promoter Regions, Genetic; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2017 |
MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Metastasis; Promoter Regions, Genetic; Sequence Analysis, DNA | 2018 |
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Topics: Animals; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Humans; Mammary Neoplasms, Experimental; Mice; Promoter Regions, Genetic; T-Lymphocytes, Cytotoxic | 2018 |
Culturing conditions highly affect DNA methylation and gene expression levels in MCF7 breast cancer cell line.
Topics: Azacitidine; Breast Neoplasms; Cell Culture Techniques; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Neoplasm Proteins; Promoter Regions, Genetic | 2018 |
Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer.
Topics: Animals; Antigens, CD; Azacitidine; Breast Neoplasms; Cadherins; Cell Hypoxia; Cell Line, Tumor; Chick Embryo; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Models, Biological; Monoamine Oxidase; Neoplasm Invasiveness; Receptors, Interleukin-6; Vascular Endothelial Growth Factor A | 2018 |
The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2).
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cyclophosphamide; Decitabine; DNA Methylation; DNA, Neoplasm; Docetaxel; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Heparan Sulfate Proteoglycans; Humans; Methylation; MicroRNAs; Neoplasm Proteins; RNA, Neoplasm; Taxoids | 2013 |
Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Carcinoma, Ductal; Case-Control Studies; Cell Line, Tumor; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Glycolysis; Humans; Hypoxia; Isoenzymes; L-Lactate Dehydrogenase; Middle Aged; Neoplasm Proteins; Promoter Regions, Genetic; Sequence Analysis, DNA | 2013 |
Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.
Topics: Azacitidine; Bone Neoplasms; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Collagen; Dactinomycin; DNA Methylation; Drug Combinations; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Laminin; Mutation; Neoplasm Invasiveness; Peptides, Cyclic; Proteoglycans; Proto-Oncogene Protein c-ets-1; Receptor, Endothelin A; RNA Stability; RNA, Messenger; Transcription, Genetic | 2013 |
Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Hormonal; Apoptosis; Azacitidine; Breast Neoplasms; Cell Survival; Chromatin Assembly and Disassembly; Decitabine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MCF-7 Cells; Tamoxifen; Time Factors; Transfection | 2013 |
Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Death; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Insulin-Like Growth Factor Binding Protein 3; MCF-7 Cells; RNA, Small Interfering; Transcription Factor AP-2; Tumor Suppressor Protein p53 | 2013 |
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.
Topics: Aminoquinolines; Anthraquinones; Azacitidine; Azo Compounds; Base Sequence; Breast Neoplasms; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Replication; Enzyme Inhibitors; Female; Fluorometry; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Pyrimidines; Reproducibility of Results; Signal Transduction; Transition Temperature | 2013 |
Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells.
Topics: Animals; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; CpG Islands; Cytidine Deaminase; Decitabine; DNA Methylation; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Genetic Complementation Test; HEK293 Cells; Humans; Mammary Glands, Human; Matrix Metalloproteinases; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2013 |
Aberrant NDRG1 methylation associated with its decreased expression and clinicopathological significance in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Neoplasm Metastasis; Promoter Regions, Genetic | 2013 |
Epigenetic modifications of prostate-derived Ets transcription factor in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA Methylation; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Male; MCF-7 Cells; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets | 2013 |
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Lobular; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Kinase C; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Array Analysis; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Matrix Metalloproteinase 2; MCF-7 Cells; S-Adenosylmethionine; Urokinase-Type Plasminogen Activator | 2014 |
Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region.
Topics: 5' Untranslated Regions; Acetylation; Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Loss of Heterozygosity; Promoter Regions, Genetic; RNA, Messenger | 2013 |
Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.
Topics: 3' Untranslated Regions; Azacitidine; Base Pairing; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin; Epithelial-Mesenchymal Transition; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HMGB3 Protein; Humans; MicroRNAs; Neoplasm Invasiveness; Repressor Proteins; Tumor Suppressor Proteins | 2013 |
Down-regulation of tripartite-motif containing 22 expression in breast cancer is associated with a lack of p53-mediated induction.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Camptothecin; DNA Damage; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; MCF-7 Cells; Minor Histocompatibility Antigens; Paclitaxel; Promoter Regions, Genetic; Repressor Proteins; Topoisomerase I Inhibitors; Tripartite Motif Proteins; Tubulin Modulators; Tumor Suppressor Protein p53 | 2013 |
High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; DNA Methylation; Drug Resistance, Neoplasm; Estrogen Antagonists; Estrogen Receptor alpha; Female; Humans; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Repressor Proteins; Tamoxifen | 2014 |
Circumvention of drug-resistance via decitabine-mediated DNMT1 depletion.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Polyethylene Glycols; Polyethyleneimine | 2013 |
Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism.
Topics: Adult; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Middle Aged; Neoplasm Proteins; Receptors, Estrogen | 2014 |
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.
Topics: Animals; Azacitidine; Breast; Breast Neoplasms; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Estrogens; Female; MicroRNAs; Rats; Rats, Inbred ACI; Resveratrol; Stilbenes | 2014 |
Small activating RNA restores the activity of the tumor suppressor HIC-1 on breast cancer.
Topics: Adult; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kruppel-Like Transcription Factors; Oligonucleotide Array Sequence Analysis; RNA; Tissue Array Analysis; Transcriptome; Up-Regulation | 2014 |
Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; Group III Phospholipases A2; Group X Phospholipases A2; Humans; Hydroxamic Acids; MCF-7 Cells; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Nude; Neoplasm Invasiveness; Phthalimides; Reverse Transcriptase Polymerase Chain Reaction; Suramin; Tryptophan; Xenograft Model Antitumor Assays | 2014 |
5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; COUP Transcription Factor II; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Hydroxamic Acids; MCF-7 Cells; Real-Time Polymerase Chain Reaction | 2014 |
DNA methylation of heparanase promoter influences its expression and associated with the progression of human breast cancer.
Topics: Azacitidine; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; MCF-7 Cells; Neoplasm Invasiveness; Promoter Regions, Genetic | 2014 |
5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells.
Topics: Anoikis; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; Female; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Spheroids, Cellular; Tumor Cells, Cultured | 2014 |
Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI.
Topics: Apoptosis; Azacitidine; Breast Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Decitabine; Female; G2 Phase Cell Cycle Checkpoints; Genetic Vectors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methyltransferases; Protein Kinases; rho GTP-Binding Proteins; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Transfection; Tumor Suppressor Protein p53 | 2014 |
The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA; DNA Methylation; Epigenesis, Genetic; Female; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Methyltransferases; Promoter Regions, Genetic; Shelterin Complex; Telomere; Telomere Homeostasis; Telomere-Binding Proteins | 2014 |
Aberrant promoter DNA methylation inhibits bone morphogenetic protein 2 expression and contributes to drug resistance in breast cancer.
Topics: Azacitidine; Bone Morphogenetic Protein 2; Breast Neoplasms; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; MCF-7 Cells; Neoplasm Staging; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering | 2014 |
Lidocaine and ropivacaine, but not bupivacaine, demethylate deoxyribonucleic acid in breast cancer cells in vitro.
Topics: Amides; Anesthetics, Local; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Bupivacaine; Cell Survival; Decitabine; DNA Methylation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Epigenesis, Genetic; Female; Humans; Lidocaine; MCF-7 Cells; Ropivacaine; Tumor Cells, Cultured | 2014 |
Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
Topics: Animals; Azacitidine; Breast Neoplasms; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Computer Simulation; Decitabine; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Glycerol-3-Phosphate O-Acyltransferase; Humans; Male; Mice; RNA, Small Interfering; Testis | 2014 |
Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Female; Gene Regulatory Networks; Genes, Neoplasm; Humans; Melanoma; Signal Transduction; Transcription, Genetic; Up-Regulation | 2014 |
Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.
Topics: Azacitidine; Breast Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Molecular Targeted Therapy; Neoplasm Invasiveness; Promoter Regions, Genetic | 2014 |
Fibronectin affects transient MMP2 gene expression through DNA demethylation changes in non-invasive breast cancer cell lines.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Fibronectins; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Time Factors; Transcriptional Activation | 2014 |
Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Kaplan-Meier Estimate; Promoter Regions, Genetic; Proto-Oncogene Proteins c-vav | 2014 |
A novel tumor suppressor function of Kindlin-3 in solid cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Heterografts; Humans; Integrin beta3; Melanoma; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Transplantation; Phosphorylation; RNA Interference; RNA, Messenger; RNA, Small Interfering; Talin | 2014 |
Identification of novel epigenetically inactivated gene PAMR1 in breast carcinoma.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Mammary Glands, Human; Organ Specificity; Promoter Regions, Genetic; Serine Proteases | 2015 |
Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.
Topics: Aldehyde Dehydrogenase; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Breast Neoplasms; Caspase 9; Cell Line, Tumor; Chemistry, Pharmaceutical; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Dose-Response Relationship, Drug; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Mice, Inbred NOD; Mice, SCID; Nanomedicine; Nanoparticles; Neoplastic Stem Cells; Polyesters; Polyethylene Glycols; Spheroids, Cellular; Technology, Pharmaceutical; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
MiR-335 inhibits migration of breast cancer cells through targeting oncoprotein c-Met.
Topics: Azacitidine; Breast Neoplasms; Cell Movement; Cell Proliferation; Decitabine; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; MCF-7 Cells; MicroRNAs; Neoplasm Invasiveness; Proto-Oncogene Proteins c-met | 2015 |
The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition.
Topics: Antigens, CD; Azacitidine; Breast Neoplasms; Cadherins; CCCTC-Binding Factor; Cell Line, Tumor; Cell Movement; Cells, Cultured; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epithelial-Mesenchymal Transition; Female; Gene Silencing; HMGA2 Protein; Humans; Promoter Regions, Genetic; Repressor Proteins; Transforming Growth Factor beta | 2015 |
Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2'-deoxycytidine in human breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Catechin; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; MCF-7 Cells; Plant Extracts; Random Amplified Polymorphic DNA Technique; Tea | 2015 |
miR-491-5p functions as a tumor suppressor by targeting JMJD2B in ERα-positive breast cancer.
Topics: 3' Untranslated Regions; Adult; Aged; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Jumonji Domain-Containing Histone Demethylases; MCF-7 Cells; MicroRNAs; Middle Aged | 2015 |
Elevation of soluble guanylate cyclase suppresses proliferation and survival of human breast cancer cells.
Topics: Animals; Apoptosis; Azacitidine; Bradykinin; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cell Survival; Cyclic GMP; Decitabine; DNA Methylation; Female; Guanylate Cyclase; Humans; MCF-7 Cells; Mice; Mice, Nude; Nitric Oxide; Nitroprusside; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2015 |
Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13;17)(q12;q25) after prior breast cancer and acute promyelocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Chromosome Deletion; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 13; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Promyelocytic, Acute; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Translocation, Genetic | 2015 |
Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.
Topics: ADAM Proteins; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Calreticulin; Cell Line, Tumor; Cohort Studies; Female; Fertilins; Humans; Immunohistochemistry; Lung Neoplasms; Melanoma-Specific Antigens; Membrane Glycoproteins | 2015 |
Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hydroxamic Acids; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
[Interaction between miR-21 and DNA methylation in different breast cancer cells].
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; MicroRNAs; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Real-Time Polymerase Chain Reaction; Up-Regulation | 2015 |
Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing.
Topics: Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Female; HLA-A2 Antigen; Humans; Immunotherapy; Interferon-gamma; MCF-7 Cells; Membrane Proteins; Microscopy, Fluorescence; Multiple Myeloma; Peptides; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Up-Regulation | 2015 |
Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
Topics: Animals; Azacitidine; Bone Neoplasms; Breast Neoplasms; DNA Methylation; DNA, Neoplasm; Endothelin-1; Female; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasm Proteins; Osteonectin; RNA, Neoplasm; Tumor Microenvironment | 2016 |
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Immunohistochemistry; MCF-7 Cells; Phenylbutyrates; rab GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Signal Transduction; Trastuzumab; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
An Unexpected Innocent Complication Associated with Azacitidine Treatment of Myelodysplastic Syndrome: Erythema Annulare Centrifugum.
Topics: Aged; Anemia, Refractory, with Excess of Blasts; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Chemoradiotherapy; Drug Hypersensitivity; Erythema; Fatal Outcome; Female; Humans; Mastectomy, Radical; Sepsis | 2016 |
Effect of 5-azacytidine on miRNA expression in human breast cancer cells with different sensitivity to cytostatics.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Cytostatic Agents; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; MicroRNAs | 2016 |
Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity.
Topics: Antineoplastic Agents; Azacitidine; Benzamides; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Exons; Female; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; MCF-7 Cells; Methotrexate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Promoter Regions, Genetic; Pyridines; Time Factors | 2016 |
Factors affecting the persistence of drug-induced reprogramming of the cancer methylome.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cellular Reprogramming; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Promoter Regions, Genetic | 2016 |
Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.
Topics: Adult; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glucosyltransferases; Humans; MCF-7 Cells; Neoplasm Invasiveness; Promoter Regions, Genetic | 2016 |
Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Carcinoma, Basal Cell; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Therapy, Combination; Female; High-Throughput Nucleotide Sequencing; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplastic Stem Cells; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2016 |
DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Female; Humans; Immunotherapy, Adoptive; Mammary Neoplasms, Experimental; MCF-7 Cells; Mice; Mice, Inbred BALB C; T-Lymphocytes | 2016 |
Decreased expression of EZH2 reactivates RASSF2A by reversal of promoter methylation in breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; CpG Islands; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Knockdown Techniques; Humans; MCF-7 Cells; Promoter Regions, Genetic; Tumor Suppressor Proteins; Up-Regulation | 2016 |
DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Claudins; DNA Methylation; Epigenesis, Genetic; Female; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Methyl-CpG-Binding Protein 2; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Young Adult | 2016 |
DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Azacitidine; Breast; Breast Neoplasms; Carcinogenesis; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Demethylation; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Glycogen Synthase Kinase 3; Humans; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Wnt Signaling Pathway | 2016 |
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Topics: Animals; Azacitidine; Bone Neoplasms; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Nucleus; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Nuclear Proteins; Proto-Oncogene Proteins c-met; Signal Transduction; Tumor Microenvironment; Tumor Suppressor Proteins | 2017 |
Astrocyte-induced Reelin expression drives proliferation of Her2
Topics: Astrocytes; Azacitidine; Brain Neoplasms; Breast Neoplasms; Cell Adhesion Molecules, Neuronal; Cell Division; Coculture Techniques; Culture Media, Serum-Free; DNA Methylation; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Nerve Tissue Proteins; Receptor, ErbB-2; Reelin Protein; RNA Interference; RNA, Small Interfering; Serine Endopeptidases; Spheroids, Cellular; Transcriptional Activation; Triple Negative Breast Neoplasms; Tumor Cells, Cultured | 2017 |
Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Exons; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Variation; Humans; MCF-7 Cells; Receptors, Estrogen; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2017 |
Comparative epigenomics of human and mouse mammary tumors.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Databases, Genetic; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mammary Neoplasms, Animal; Mice; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Structure-Activity Relationship; Tissue Inhibitor of Metalloproteinase-3 | 2009 |
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Female; Fructose-Bisphosphatase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Middle Aged; Neoplasms; Promoter Regions, Genetic | 2008 |
Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Line; Cell Movement; Chemotherapy, Adjuvant; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Immunoenzyme Techniques; Lasers; Membrane Microdomains; Membrane Transport Proteins; Middle Aged; Molecular Sequence Data; Myelin and Lymphocyte-Associated Proteolipid Proteins; Myelin Proteins; Prognosis; Promoter Regions, Genetic; Proteolipids; Reverse Transcriptase Polymerase Chain Reaction; Survival Rate; Wound Healing | 2009 |
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Topics: Amino Acid Oxidoreductases; Azacitidine; Blotting, Western; Breast Neoplasms; Catalysis; Cell Line; Cell Line, Tumor; Decitabine; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Immunohistochemistry; Mammary Glands, Human; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Growth inhibition of human cancer cells by 5-aza-2'-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Suppressor Protein p14ARF | 2009 |
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.
Topics: Animals; Azacitidine; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA Modification Methylases; Female; Gene Silencing; Genes, Tumor Suppressor; HeLa Cells; Humans; Liver Neoplasms; Mice; Quinolines; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Butyrates; Colonic Neoplasms; Decitabine; Enzyme Inhibitors; HT29 Cells; Humans; Hydroxamic Acids; Nuclear Proteins; Receptors, Glucocorticoid; RNA-Binding Proteins; Serine-Arginine Splicing Factors | 2009 |
Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-2 | 2009 |
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Topics: Adenocarcinoma; Apoptosis Regulatory Proteins; Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; Cytidine; Cytidine Deaminase; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Neoplasm Proteins; Receptors, Estrogen; S Phase; Tumor Stem Cell Assay; Vorinostat | 2010 |
The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines.
Topics: Azacitidine; Breast Neoplasms; Butyrates; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Radiation Dosage; Radiation-Sensitizing Agents | 2009 |
CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors.
Topics: Adenocarcinoma; Azacitidine; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Hydroxamic Acids; Neoplasm Proteins; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2010 |
Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene.
Topics: Apoptosis; Apoptotic Protease-Activating Factor 1; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Female; Humans; RNA, Messenger | 2009 |
Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter.
Topics: Azacitidine; Breast; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Colonic Neoplasms; DNA Methylation; Female; Humans; Long Interspersed Nucleotide Elements; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic | 2009 |
5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Blood Urea Nitrogen; Blotting, Western; Breast Neoplasms; Cell Nucleus; Cisplatin; Colonic Neoplasms; Creatinine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; Drug Therapy, Combination; Female; Histones; Kidney Diseases; Male; Mammary Neoplasms, Experimental; Metallothionein; Neoplasms, Experimental; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2009 |
Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Biomarkers, Tumor; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Middle Aged; Molecular Sequence Data; Neoplasm Staging; Receptor, EphA5; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger | 2010 |
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 11; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Guanine Nucleotide Exchange Factors; Humans; Hydroxamic Acids; Male; Nucleic Acid Hybridization; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Rho Guanine Nucleotide Exchange Factors; Transfection; Tumor Suppressor Proteins | 2009 |
Tamoxifen epigenetically modulates CXCL12 expression in MCF-7 breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Cytosine; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Sequence Analysis, DNA; Tamoxifen | 2010 |
Effects of decitabine on the expression of selected endogenous control genes in human breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Docetaxel; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Taxoids | 2010 |
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chemokines; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Humans; Intercellular Signaling Peptides and Proteins; Nerve Growth Factors; Netrins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Ubiquitin Thiolesterase; Up-Regulation | 2010 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Topics: Adenosine; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors | 2009 |
[Traditional medicine CDP and promoter demethylation in breast cancer cell lines].
Topics: Azacitidine; Breast Neoplasms; Cadherins; Cell Line, Tumor; CpG Islands; DNA Methylation; Drugs, Chinese Herbal; Genes, p16; Humans | 2009 |
Epigenetic silencing of TNFSF7 (CD70) by DNA methylation during progression to breast cancer.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; CD27 Ligand; Cell Line, Tumor; CpG Islands; Disease Progression; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger | 2010 |
X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation.
Topics: 5' Flanking Region; Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Down-Regulation; Ectodysplasins; Female; Humans; Promoter Regions, Genetic; Xedar Receptor | 2010 |
Expression and regulation mechanisms of Sonic Hedgehog in breast cancer.
Topics: Azacitidine; Breast; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Female; Hedgehog Proteins; Humans; Immunohistochemistry; Middle Aged; Neoplasms; NF-kappa B; RNA, Messenger; Transcription Factors; Up-Regulation; Zinc Finger Protein GLI1 | 2010 |
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer.
Topics: Animals; Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Primers; Enzyme Inhibitors; Epigenesis, Genetic; Female; Humans; LIM Domain Proteins; Mice; Mice, SCID; Microfilament Proteins; NF-kappa B; Promoter Regions, Genetic; Receptors, Estrogen; Tumor Stem Cell Assay | 2010 |
BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas.
Topics: Alternative Splicing; Azacitidine; Breast Neoplasms; Carcinoma; CCCTC-Binding Factor; Cell Line, Tumor; Decitabine; DNA-Binding Proteins; Exons; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution | 2010 |
Altered DNA methylation is associated with docetaxel resistance in human breast cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Docetaxel; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors | 2010 |
DNA methylation-related vitamin D receptor insensitivity in breast cancer.
Topics: Azacitidine; Blotting, Western; Bone Density Conservation Agents; Breast; Breast Neoplasms; Calcitriol; Cell Proliferation; CpG Islands; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Humans; Promoter Regions, Genetic; Receptors, Calcitriol; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured | 2010 |
Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Female; Flow Cytometry; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2010 |
Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Decitabine; DNA Methylation; Extracellular Signal-Regulated MAP Kinases; Female; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 5 | 2010 |
Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer.
Topics: Acetylation; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; NF-kappa B; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2010 |
Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Germ-Line Mutation; Humans; Loss of Heterozygosity; Mice; Mice, SCID; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Fibroblast Growth Factor, Type 4; Selection, Genetic; Xenograft Model Antitumor Assays | 2010 |
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; PTEN Phosphohydrolase; S-Adenosylmethionine; Tamoxifen; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Epigenetic up-regulation of leukemia inhibitory factor (LIF) gene during the progression to breast cancer.
Topics: 5' Flanking Region; Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; CpG Islands; Disease Progression; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia Inhibitory Factor; Methyl-CpG-Binding Protein 2; Molecular Sequence Data; Precancerous Conditions; Promoter Regions, Genetic; Protein Binding; RNA Interference; RNA, Messenger; Sp1 Transcription Factor; Tumor Stem Cell Assay; Up-Regulation | 2011 |
Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Decitabine; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; Hydroxamic Acids; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA Interference; Transplantation, Heterologous | 2011 |
Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mice; Mice, Nude; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Syk Kinase | 2012 |
Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Silencing; Hydroxamic Acids; Mammary Glands, Animal; Mammary Neoplasms, Animal; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2011 |
Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; TCF Transcription Factors | 2011 |
Definition of the landscape of promoter DNA hypomethylation in liver cancer.
Topics: Aged; Azacitidine; Breast Neoplasms; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Ovarian Neoplasms; Promoter Regions, Genetic | 2011 |
Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HCT116 Cells; HL-60 Cells; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; Mutation; Neoplasm Invasiveness; Polymorphism, Genetic; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors | 2011 |
Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines.
Topics: 5' Flanking Region; Azacitidine; Breast Neoplasms; Cells, Cultured; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Parathyroid Hormone-Related Protein; Promoter Regions, Genetic | 2011 |
Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Computational Biology; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Polymerase Chain Reaction; Promoter Regions, Genetic | 2011 |
Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA Helicases; DNA Methylation; DNA-Binding Proteins; Female; Gene Silencing; Histones; Humans; Polycomb-Group Proteins; Repressor Proteins; RNA Polymerase II; Transcription Initiation Site; Transcription, Genetic | 2011 |
Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Plasminogen Activator Inhibitor 1; Urokinase-Type Plasminogen Activator | 2011 |
Epigenetic silencing of the tumor suppressor klotho in human breast cancer.
Topics: Acetylation; Azacitidine; Base Sequence; Breast; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Female; Gene Silencing; Glucuronidase; Histones; Humans; Klotho Proteins; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2012 |
Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α.
Topics: Acetylation; Animals; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Capillary Permeability; Cell Line, Tumor; Chromatin; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Drug Resistance, Neoplasm; E-Box Elements; Estrogen Receptor alpha; Estrogens; Female; Histone Deacetylase 1; Histones; Humans; Mice; Nuclear Proteins; Promoter Regions, Genetic; Protein Transport; RNA, Small Interfering; Tamoxifen; Twist-Related Protein 1; Valproic Acid | 2012 |
Integrated epigenetics of human breast cancer: synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; MicroRNAs; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells.
Topics: Apoptosis; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Growth Processes; Decitabine; DNA Methylation; DNA Mismatch Repair; DNA Repair; Drug Interactions; Epigenesis, Genetic; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic | 2012 |
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromosomes, Human, Pair 3; Decitabine; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Lysine; Multigene Family; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2011 |
Increased proliferation and chemosensitivity of human mesenchymal stromal cells expressing fusion yeast cytosine deaminase.
Topics: Adipose Tissue; Apoptosis; Azacitidine; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytarabine; Cytosine Deaminase; Drug Screening Assays, Antitumor; Female; Fluorouracil; Genetic Engineering; Green Fluorescent Proteins; Humans; Mesenchymal Stem Cells; Recombinant Fusion Proteins; Retroviridae; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transduction, Genetic; Transgenes | 2012 |
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Bone Marrow Cells; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA Damage; DNA Methylation; DNA Modification Methylases; Gene Silencing; Humans; Leukemia; Mice; Molecular Sequence Data; Neoplastic Stem Cells; Promoter Regions, Genetic; Signal Transduction; Tumor Cells, Cultured | 2012 |
MTA1 expression correlates significantly with ER-alpha methylation in breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Mammary Glands, Human; Methylation; Middle Aged; Neoplasm Staging; Repressor Proteins; Trans-Activators | 2012 |
The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Breast Neoplasms; Carbohydrate Epimerases; Chromatin; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Promoter Regions, Genetic; Protein Processing, Post-Translational; Transcription Factor 4; Transcription Factors; Transcription, Genetic; Wnt Signaling Pathway | 2012 |
Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer.
Topics: Apoptosis; Azacitidine; Breast Neoplasms; Cell Proliferation; DNA Methylation; Drug Resistance, Neoplasm; ErbB Receptors; Estrogens; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Neoplasm; Growth Differentiation Factor 15; Humans; MCF-7 Cells; Quinazolines; Receptors, Estrogen; Receptors, Progesterone; Recombinant Proteins; Tamoxifen; Trefoil Factor-1; Tumor Suppressor Proteins | 2012 |
Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Biological Transport; Breast Neoplasms; Cell Membrane; Decitabine; DNA Methylation; Doxorubicin; Drug Delivery Systems; Drug Resistance, Neoplasm; Endocytosis; Epigenesis, Genetic; Epigenomics; Female; Humans; Lipid Metabolism; MCF-7 Cells | 2012 |
Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Breast Neoplasms; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Decitabine; Depsipeptides; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; Histone Deacetylase Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Kidney Neoplasms; Methyltransferases; Recombinant Proteins; Tumor Suppressor Proteins | 2012 |
Global identification of genes regulated by estrogen signaling and demethylation in MCF-7 breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Estradiol; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Promoter Regions, Genetic; Proteins; Signal Transduction; Transcriptome | 2012 |
ING1 and 5-azacytidine act synergistically to block breast cancer cell growth.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Hydroxamic Acids; Indoles; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Mice; Mice, SCID; Nuclear Proteins; Panobinostat; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2012 |
5-aza-2'-Deoxycytidine enhances the radiosensitivity of breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Proliferation; Colony-Forming Units Assay; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2013 |
Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer.
Topics: Adipose Tissue; Azacitidine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Receptors, Prostaglandin E, EP2 Subtype; Reference Values; Stromal Cells | 2012 |
Transcriptional regulation of hTREX84 in human cancer cells.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; DNA-Binding Proteins; Exons; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Nuclear Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; RNA-Binding Proteins; Sequence Analysis, DNA; Sulfites; Transcription Factor RelA; Transcription, Genetic | 2012 |
Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer.
Topics: Azacitidine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; MCF-7 Cells; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Analysis, DNA; tert-Butylhydroperoxide; Transcription Factor AP-2; Transcription, Genetic | 2013 |
CpG island shore methylation regulates caveolin-1 expression in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; CpG Islands; DNA Methylation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Oncogene Proteins; Promoter Regions, Genetic | 2013 |
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Embryonal; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Luciferases; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Receptor Subfamily 6, Group A, Member 1; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Time Factors; Tissue Array Analysis; Transcription, Genetic; Transfection; Tretinoin; Valproic Acid | 2013 |
Highly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Carcinogens; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Epigenomics; Female; G2 Phase; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Internationality; MCF-7 Cells; Vorinostat | 2013 |
Identification of novel breast cancer-associated transcripts by UniGene database mining and gene expression analysis in normal and malignant cells.
Topics: Adult; Aged; Aged, 80 and over; Alternative Splicing; Azacitidine; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Computational Biology; Data Mining; Databases, Nucleic Acid; Expressed Sequence Tags; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Neoplasm Grading; Neoplasm Staging; Transcription, Genetic; Transcriptome | 2013 |
Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Delivery Systems; Drug Resistance, Neoplasm; Epigenomics; Female; Gene Expression Regulation, Neoplastic; Humans; Nanogels; Polyethylene Glycols; Polyethyleneimine; Tumor Cells, Cultured | 2013 |
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Genistein; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Nude; Mice, Transgenic; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Tamoxifen; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Synergistic antineoplastic action of DNA methylation inhibitor 5-AZA-2'-deoxycytidine and histone deacetylase inhibitor depsipeptide on human breast carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Decitabine; DNA Methylation; DNA Primers; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Female; Gelsolin; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; In Vitro Techniques; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serpins; Tumor Cells, Cultured | 2003 |
Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma.
Topics: Azacitidine; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Epithelial Cells; Exons; Female; Gene Expression Regulation, Neoplastic; Humans; Nerve Tissue Proteins; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synucleins; Tumor Cells, Cultured | 2003 |
Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells.
Topics: 14-3-3 Proteins; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; Cadherins; Cell Line, Tumor; Decitabine; Depsipeptides; DNA; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Synergism; Exonucleases; Exoribonucleases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Inhibitory Concentration 50; Neoplasm Proteins; Peptides, Cyclic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-3; Tumor Stem Cell Assay | 2003 |
Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers.
Topics: Adenocarcinoma; Azacitidine; Base Sequence; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; GTPase-Activating Proteins; Humans; Liver Neoplasms; Male; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Head and Neck Neoplasms; Humans; Hydralazine; Mice; Mice, Nude; Procainamide; Receptors, Estrogen; Receptors, Retinoic Acid; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2003 |
Mutant p53 and aberrant cytosine methylation cooperate to silence gene expression.
Topics: Azacitidine; Breast Neoplasms; Chromatin; Cytosine; Desmocollins; DNA Methylation; DNA-Cytosine Methylases; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Membrane Glycoproteins; Mutation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proteins; Serpins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.
Topics: Animals; Azacitidine; Breast Neoplasms; Carrier Proteins; Case-Control Studies; Cell Adhesion Molecules; Chromosomes, Human, Pair 11; CpG Islands; DNA; DNA Methylation; Enzyme Inhibitors; Female; Genes, Tumor Suppressor; GPI-Linked Proteins; Humans; Loss of Heterozygosity; Mice; Mice, Nude; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neoplasms, Glandular and Epithelial; Nerve Tissue Proteins; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Tumor Cells, Cultured | 2003 |
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.
Topics: Alleles; Animals; Azacitidine; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Mice; Promoter Regions, Genetic; rho GTP-Binding Proteins; Tumor Cells, Cultured | 2003 |
UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; Breast Neoplasms; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; CpG Islands; DNA Methylation; DNA-Binding Proteins; Electron Transport Complex III; Exons; Extrachromosomal Inheritance; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kruppel-Like Transcription Factors; Molecular Sequence Data; Neoplasm Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; Proteins; Repressor Proteins; RNA-Binding Protein EWS; Sarcoma; Soft Tissue Neoplasms; Translocation, Genetic; Tumor Cells, Cultured | 2003 |
Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers.
Topics: Azacitidine; Breast Neoplasms; Carcinoma, Squamous Cell; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Gene Expression; Humans; Lung Neoplasms; Microsatellite Repeats; PAX5 Transcription Factor; Promoter Regions, Genetic; Transcription Factors; Tumor Cells, Cultured | 2003 |
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cyclin D2; Cyclins; DNA Methylation; Female; Humans; Lung Neoplasms; Middle Aged; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.
Topics: Age Factors; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chi-Square Distribution; Decitabine; DNA Methylation; DNA Modification Methylases; Estrogen Receptor beta; Female; Gene Silencing; Humans; Immunohistochemistry; Lymphatic Metastasis; Neoplasm Recurrence, Local; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Uterine Cervical Dysplasia | 2003 |
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Division; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrogen Receptor alpha; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxylamines; Inhibitory Concentration 50; Quinolines; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Tumor Cells, Cultured | 2003 |
CHFR-associated early G2/M checkpoint defects in breast cancer cells.
Topics: Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle Proteins; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Flow Cytometry; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Mitosis; Mitotic Index; Neoplasm Proteins; Poly-ADP-Ribose Binding Proteins; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 2004 |
MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine.
Topics: Acetylation; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Breast Neoplasms; Chromatin; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured | 2004 |
Evaluation of antineoplastic action of 5-aza-2'-deoxycytidine (Dacogen) and docetaxel (Taxotere) on human breast, lung and prostate carcinoma cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cadherins; Cell Line, Tumor; Decitabine; DNA; Docetaxel; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Lung Neoplasms; Male; Prostatic Neoplasms; Proteins; Serpins; Taxoids; Time Factors | 2004 |
Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Primers; DNA, Neoplasm; Female; Gene Frequency; Gene Silencing; GTPase-Activating Proteins; Humans; Neoplasm Invasiveness; Polymerase Chain Reaction; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2004 |
Chemically induced DNA hypomethylation in breast carcinoma cells detected by the amplification of intermethylated sites.
Topics: Azacitidine; Breast Neoplasms; Carcinoma; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Humans; Nucleic Acid Amplification Techniques; Promoter Regions, Genetic | 2004 |
Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Breast Neoplasms; Chromatin; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Promoter Regions, Genetic | 2004 |
Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Breast Neoplasms; Carcinoma, Ductal; Carcinoma, Intraductal, Noninfiltrating; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Precursors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Neoplasm Invasiveness; Phenotype; Protein-Tyrosine Kinases; Stilbenes; Syk Kinase | 2005 |
Effects of DNA methylation inhibitor on down-regulation of ribonuclease inhibitor expression in cancer cell lines.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Female; Humans; Male; Nerve Tissue Proteins; Prostatic Neoplasms; RNA, Messenger; Stomach Neoplasms | 2004 |
Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Chemokines, C; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lymphokines; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Protein Phosphatase 2; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Tumor Cells, Cultured | 2004 |
Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Azacitidine; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Mutational Analysis; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Microtubule-Associated Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Transfection; Up-Regulation | 2005 |
Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Cycle Proteins; Chromosome Mapping; DNA Methylation; Epithelial Cells; Female; Gene Expression Profiling; Humans; Molecular Sequence Data; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Tumor Cells, Cultured | 2005 |
Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Chromatin; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Methyl-CpG-Binding Protein 2; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors; Tumor Cells, Cultured | 2005 |
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Decitabine; DNA Primers; Enzyme Inhibitors; Histone Deacetylases; Histones; Humans; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Time Factors; Tretinoin; Valproic Acid | 2005 |
CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.
Topics: Adult; Antigens, CD34; Azacitidine; Base Sequence; Bone Marrow Cells; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA, Neoplasm; Female; Fetal Blood; Gene Expression; Genes, myc; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Insulin-Like Growth Factor II; Pluripotent Stem Cells; RNA Interference; RNA-Binding Proteins; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Transfection | 2005 |
Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Exons; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Introns; Molecular Sequence Data; Neoplasm Metastasis; Promoter Regions, Genetic; RNA, Messenger; Transforming Growth Factor beta; Tropomyosin | 2005 |
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Azacitidine; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cadherins; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Ki-67 Antigen; Middle Aged; Neoplasm Invasiveness; Predictive Value of Tests; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Suppressor Protein p53 | 2005 |
Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Silencing; Humans; Mice; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transcription Factor AP-2 | 2005 |
The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer.
Topics: Azacitidine; Base Sequence; Breast Neoplasms; Breast Neoplasms, Male; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Chromosomes, Human, Pair 11; Cyclin D1; Decitabine; DNA Methylation; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Introns; Male; Middle Aged; Molecular Sequence Data; RNA, Messenger | 2005 |
BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy.
Topics: Aneuploidy; Antimetabolites, Antineoplastic; Azacitidine; BRCA1 Protein; Breast; Breast Neoplasms; Cell Line, Tumor; Chromosomes, Human, Pair 17; Decitabine; DNA Methylation; Female; Gene Dosage; Gene Expression; Genes, BRCA1; Humans; Hydroxamic Acids; Lymphocytes; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2005 |
Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Breast Neoplasms; CCAAT-Enhancer-Binding Protein-delta; Chromatin Immunoprecipitation; DNA Methylation; Down-Regulation; Electrophoretic Mobility Shift Assay; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Promoter Regions, Genetic; Resting Phase, Cell Cycle; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured | 2006 |
Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer.
Topics: Acetylation; Azacitidine; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2006 |
[The synergistic inhibitory effect of 5-aza-2-deoxycytidine and Tamoxifen on estrogen receptor alpha negative breast cancer cell lines in vitro].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Drug Synergism; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen | 2005 |
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Calcitriol; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Decitabine; Female; Humans; Hydroxamic Acids; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Receptors, Calcitriol; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured | 2006 |
Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue.
Topics: Antigens, Neoplasm; Azacitidine; Breast; Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Colon; CpG Islands; Decitabine; DNA Methylation; Epithelial Cell Adhesion Molecule; Female; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Promoter Regions, Genetic; RNA, Messenger | 2007 |
Epigenetic inactivation of Betaig-h3 gene in human cancer cells.
Topics: Azacitidine; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Humans; Luciferases; Lung Neoplasms; Male; Neoplasms; Promoter Regions, Genetic; Prostatic Neoplasms; Transforming Growth Factor beta | 2006 |
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; Estrogen Antagonists; Estrogen Receptor alpha; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Promoter Regions, Genetic; Repressor Proteins; RNA, Messenger; Sin3 Histone Deacetylase and Corepressor Complex; Tamoxifen | 2006 |
Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2'-deoxycytidine (decitabine) on human breast carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Decitabine; DNA; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Neoplastic Stem Cells; S Phase; Time Factors | 2006 |
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Calcitriol; Cell Line, Tumor; Decitabine; Disease Progression; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Kallikreins; Promoter Regions, Genetic; Transcription, Genetic | 2006 |
The epigenetic basis for the aberrant expression of kallikreins in human cancers.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kallikreins; Male; Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms | 2006 |
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Targeting; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Promoter Regions, Genetic | 2006 |
Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cadherins; Cell Line, Tumor; DNA Primers; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Middle Aged; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
DNA methylation-dependent silencing of CST6 in human breast cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; CpG Islands; Cystatin M; Cystatins; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Promoter Regions, Genetic | 2006 |
Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues.
Topics: Azacitidine; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cladribine; Decitabine; DNA Methylation; Estrogen Receptor alpha; Genes, APC; Genes, BRCA1; Humans; K562 Cells; Nucleosides; Promoter Regions, Genetic; PTEN Phosphohydrolase; Vidarabine | 2006 |
Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer.
Topics: ADP-Ribosylation Factors; Apoptosis; Azacitidine; Breast Neoplasms; Cell Proliferation; Decitabine; Down-Regulation; Female; Genes, Tumor Suppressor; Humans; Ovarian Neoplasms | 2006 |
A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Cathepsin K; Cathepsins; Colonic Neoplasms; CpG Islands; Cyclin A; Cyclin A1; Decitabine; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Lung Neoplasms; Male; Middle Aged; MSX1 Transcription Factor; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Prostatic Neoplasms; Transcription Factors; Tumor Cells, Cultured | 2006 |
Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; CpG Islands; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung Neoplasms; Male; Middle Aged; Promoter Regions, Genetic; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2007 |
Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.
Topics: Adenoviridae; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; Disease Progression; DNA Methylation; DNA, Complementary; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Neoplasm Proteins; Oxidoreductases; RNA Interference; Time Factors; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2007 |
Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Carcinoma; Cell Adhesion; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; Membrane Proteins; Microfilament Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sulfites; Tumor Suppressor Proteins | 2007 |
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Down-Regulation; Doxorubicin; Drug Synergism; Enzyme Activation; Histone Deacetylase 1; Histone Deacetylases; Humans; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Transfection | 2007 |
Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Decitabine; Dinucleoside Phosphates; DNA Methylation; DNA Primers; Epigenesis, Genetic; ErbB Receptors; Female; Gefitinib; Genetic Therapy; Humans; Organ Specificity; Quinazolines; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer.
Topics: Adult; Aged; Azacitidine; Brain Neoplasms; Breast Neoplasms; CpG Islands; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Homeodomain Proteins; Humans; Middle Aged; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2007 |
[Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine].
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Ovariectomy; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2006 |
[Demethylation of estrogen receptor gene and its re-expression in estrogen receptor-negative breast].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Azacitidine; Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen | 2006 |
Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer.
Topics: Azacitidine; Breast Neoplasms; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; E1A-Associated p300 Protein; Estrogen Receptor alpha; Humans; Promoter Regions, Genetic; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Ubiquitin-Protein Ligases | 2007 |
Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR.
Topics: 3' Untranslated Regions; Antigens, Surface; Azacitidine; Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Decitabine; ELAV Proteins; ELAV-Like Protein 1; Enzyme Inhibitors; Epigenesis, Genetic; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Humans; Hydroxamic Acids; Immunoprecipitation; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Transfection | 2008 |
Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer.
Topics: Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; MicroRNAs; RNA, Neoplasm; Tumor Cells, Cultured | 2008 |
The effects of nucleoside analogues on promoter methylation of selected tumor suppressor genes in MCF-7 and MDA-MB-231 breast cancer cell lines.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cladribine; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Genes, APC; Genes, BRCA1; Genes, Tumor Suppressor; Humans; Nucleosides; Promoter Regions, Genetic; PTEN Phosphohydrolase; Receptors, Retinoic Acid; Vidarabine | 2007 |
Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; Female; Humans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serpins | 2007 |
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Breast Neoplasms; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Phenotype; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2008 |
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2008 |
Deleterious CHEK2 1100delC and L303X mutants identified among 38 human breast cancer cell lines.
Topics: Azacitidine; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Checkpoint Kinase 2; Codon, Nonsense; Colorectal Neoplasms; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm; Female; G1 Phase; Gene Expression Regulation, Neoplastic; Genes, cdc; Genes, p53; Humans; Male; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2009 |
Phenotypic variability in anchorage-independent growth by a human breast tumor cell line.
Topics: Azacitidine; Breast Neoplasms; Carcinosarcoma; Cell Adhesion; Cell Division; Cell Line; Culture Media; Female; Gene Expression Regulation; Hot Temperature; Humans; Isomerism; Methylcellulose; Phenotype | 1984 |
Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations.
Topics: Azacitidine; Breast Neoplasms; Down-Regulation; ErbB Receptors; Estradiol; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Keratins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Polyunsaturated Alkamides; Proteins; Receptor, ErbB-2; Receptors, Estradiol; Receptors, Progesterone; Tamoxifen; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1994 |
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; Breast Neoplasms; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Neoplastic; Guanine; Humans; Methylation; Molecular Sequence Data; Receptors, Estrogen; RNA, Messenger; Tumor Cells, Cultured | 1995 |
Regulation of gene expression involved in the progression of human breast cancer to hormone independence.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Cell Division; DNA; Epidermal Growth Factor; ErbB Receptors; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Methylation; Receptors, Estrogen; Tumor Cells, Cultured | 1993 |
Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes.
Topics: Azacitidine; Breast Neoplasms; Carrier Proteins; DNA Methylation; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins; Female; Growth Inhibitors; Humans; Polymerase Chain Reaction; Tumor Cells, Cultured | 1996 |
Expression of MAGE and BAGE genes in Japanese breast cancers.
Topics: Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Japan; Melanoma-Specific Antigens; Neoplasm Proteins; Tumor Cells, Cultured | 1997 |
Transcriptional defects underlie loss of E-cadherin expression in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cadherins; Cloning, Molecular; Decitabine; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Trans-Activators; Transcription Factor AP-2; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Decitabine; DNA Adducts; DNA Methylation; DNA Modification Methylases; Humans; Receptors, Estrogen; Tumor Cells, Cultured | 1997 |
Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells.
Topics: Azacitidine; Blotting, Southern; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Isoenzymes; Neoplasm Proteins; Promoter Regions, Genetic; Receptors, Estrogen; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2'-deoxycytidine.
Topics: Activin Receptors, Type I; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Breast Neoplasms; Decitabine; Female; Humans; Insulin-Like Growth Factor II; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Estrogen; Receptors, Transforming Growth Factor beta; Repressor Proteins; Sp1 Transcription Factor; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation.
Topics: Azacitidine; Breast Neoplasms; Cell Line; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness; Transcription, Genetic; Urokinase-Type Plasminogen Activator | 1999 |
DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2'-deoxycytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Division; Decitabine; DNA Methylation; Female; Humans; Receptors, Retinoic Acid; Tumor Cells, Cultured | 1999 |
Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Breast Neoplasms; Cell Line; Chromatin; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Receptors, Estrogen; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured | 2000 |
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
Topics: 14-3-3 Proteins; Azacitidine; Breast; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; CpG Islands; Decitabine; DNA Methylation; DNA Repair; Epithelial Cells; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Neoplasm Proteins; Protein Biosynthesis; Proteins; Radiation Tolerance; Recombinant Fusion Proteins; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 2000 |
Regional methylation of the 5' end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cervix Uteri; Chromosomal Proteins, Non-Histone; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation; Gene Silencing; Genes, BRCA1; Germ Cells; Humans; Kidney; Male; Methyl-CpG-Binding Protein 2; Promoter Regions, Genetic; Repressor Proteins; Transcriptional Activation; Transfection | 2000 |
Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells.
Topics: Adenocarcinoma; Azacitidine; Base Sequence; Breast Neoplasms; Clone Cells; CpG Islands; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Reporter; Humans; Molecular Sequence Data; Neoplasm Proteins; Promoter Regions, Genetic; Receptors, Retinoic Acid; Sequence Analysis, DNA; Transcriptional Activation; Transfection; Tretinoin; Tumor Cells, Cultured | 2000 |
Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency.
Topics: Activin Receptors, Type I; Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Colonic Neoplasms; Cyclin A; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Sp1 Transcription Factor; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2000 |
Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer.
Topics: Alleles; Azacitidine; Breast Neoplasms; Chromosomes, Human, Pair 3; Decitabine; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Loss of Heterozygosity; Promoter Regions, Genetic; Receptors, Retinoic Acid; Tumor Cells, Cultured; Up-Regulation | 2001 |
Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Movement; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Monomeric GTP-Binding Proteins; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Promoter Regions, Genetic; Transcription Factors; Transfection; Tumor Cells, Cultured | 2001 |
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
Topics: Acid Anhydride Hydrolases; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Blotting, Northern; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; CpG Islands; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Loss of Heterozygosity; Lung Neoplasms; Male; Middle Aged; Neoplasm Proteins; Protein Biosynthesis; Proteins; RNA, Messenger | 2001 |
5-azaC treatment enhances expression of transforming growth factor-beta receptors through down-regulation of Sp3.
Topics: Activin Receptors, Type I; Azacitidine; Breast Neoplasms; Cell Nucleus; Colonic Neoplasms; DNA-Binding Proteins; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sp3 Transcription Factor; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Decitabine; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Receptors, Estrogen; Receptors, Retinoic Acid; Tumor Cells, Cultured | 2001 |
Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Biological Transport; Breast Neoplasms; Carrier Proteins; CpG Islands; Decitabine; Dipyridamole; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Female; Folic Acid Antagonists; Gene Silencing; Histone Deacetylases; Histones; Humans; Ion Pumps; Membrane Transport Proteins; Methotrexate; Promoter Regions, Genetic; Reduced Folate Carrier Protein | 2001 |
Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences.
Topics: Amino Acid Motifs; Azacitidine; Base Sequence; Binding Sites; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Exons; gamma-Synuclein; Humans; Introns; Models, Genetic; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Nerve Tissue Proteins; Promoter Regions, Genetic; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Topics: Acetylation; Azacitidine; Breast Neoplasms; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Synergism; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Fulvestrant; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Receptors, Estrogen; RNA, Messenger; Tumor Cells, Cultured | 2001 |
CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; CpG Islands; Decitabine; DNA Methylation; Exons; Gene Expression Regulation, Neoplastic; Humans; Introns; Kallikreins; Luciferases; Promoter Regions, Genetic; RNA, Messenger | 2001 |
Glypican-3 expression is silenced in human breast cancer.
Topics: Azacitidine; Breast; Breast Neoplasms; Carcinoma, Hepatocellular; Decitabine; DNA Methylation; DNA, Neoplasm; Dosage Compensation, Genetic; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Glypicans; Heparan Sulfate Proteoglycans; Humans; Liver Neoplasms; Loss of Heterozygosity; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Tumor Stem Cell Assay; X Chromosome | 2001 |
Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Carcinoma; Chromosome Deletion; Chromosomes, Human, Pair 17; Cohort Studies; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Follow-Up Studies; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, p53; Humans; Kruppel-Like Transcription Factors; Loss of Heterozygosity; Neoplasm Proteins; Prognosis; Prospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Survival Analysis; Transcription Factors; Tumor Cells, Cultured | 2001 |
Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Connexin 26; Connexins; CpG Islands; Decitabine; DNA Methylation; Female; Humans; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells.
Topics: Antibiotics, Antineoplastic; Azacitidine; Breast Neoplasms; Chromatin; Decitabine; DNA Methylation; Down-Regulation; Drosophila Proteins; Enzyme Inhibitors; Fibroblasts; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Microscopy, Fluorescence; Promoter Regions, Genetic; Tropomyosin; Tumor Cells, Cultured | 2002 |
Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.
Topics: Animals; Azacitidine; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Chromosomes, Human, Pair 3; CpG Islands; Decitabine; DNA Methylation; DNA Mutational Analysis; DNA, Neoplasm; Drosophila melanogaster; Drosophila Proteins; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Kidney Neoplasms; Loss of Heterozygosity; Lung Neoplasms; Mutation, Missense; Nerve Tissue Proteins; Promoter Regions, Genetic; Receptors, Immunologic; Roundabout Proteins; Sequence Homology, Nucleic Acid; Tumor Cells, Cultured | 2002 |
Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment.
Topics: Amino Acid Sequence; Antineoplastic Agents; Azacitidine; Base Sequence; Breast; Breast Neoplasms; Calcimycin; Calcium-Binding Proteins; Cell Cycle; Cell Line; Chromosome Banding; Decitabine; DNA; DNA Probes; DNA, Neoplasm; Female; Gene Expression; Humans; Molecular Sequence Data; Multigene Family; RNA; RNA, Messenger; RNA, Neoplasm; S100 Proteins; Sequence Homology, Nucleic Acid | 1992 |
An evaluation of the putative human mammary tumour retrovirus associated with peripheral blood monocytes.
Topics: Adult; Aged; Azacitidine; Breast Neoplasms; Cloning, Molecular; Female; Giant Cells; Humans; Microscopy, Electron; Middle Aged; Monocytes; Retroviridae; RNA-Directed DNA Polymerase; Tumor Cells, Cultured | 1991 |
[Expression of antigens related to structural protein antigens of MMTV in breast cancer cells].
Topics: Antigens, Neoplasm; Antigens, Viral; Azacitidine; Breast Neoplasms; Cell Line; Clone Cells; Dexamethasone; Estradiol; Female; Humans; Immunoenzyme Techniques; Mammary Tumor Virus, Mouse; Progesterone; Viral Proteins | 1985 |
Alterations in the X chromosome replication pattern induced by 5-azacytidine in a human tumor line.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Chromosome Banding; DNA Replication; Dosage Compensation, Genetic; Gene Expression Regulation; Humans; Methylation; X Chromosome | 1986 |
Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Survival; Decitabine; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Humans; Methylation; RNA, Neoplasm; Tetrahydrouridine | 1986 |
[New cytostatics in oncological therapy].
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Chemical Phenomena; Chemistry; DNA Replication; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Lymphoma; Male; Mitolactol; Neoplasms; Nitrosourea Compounds; Testicular Neoplasms; Thyroid Neoplasms | 1974 |