Compounds > azacitidine

azacitidine and Acute Lymphoid Leukemia

azacitidine has been researched along with Acute Lymphoid Leukemia in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.12)18.7374
1990's6 (12.24)18.2507
2000's10 (20.41)29.6817
2010's26 (53.06)24.3611
2020's4 (8.16)2.80

Authors

AuthorsStudies
Alivand, MR; Emamgolizadeh, B; Mogadasi, M; Mohammadi, A; Rahmanpour, D; Solali, S1
Jia, Y; Li, C; Lin, D; Mi, Y; Wang, H; Wang, J; Wang, Z1
Anderson, D; Aya-Bonilla, C; Breese, EH; Brown, PA; Cheung, LC; Chiu, SK; Chua, GA; Cruickshank, MN; Faulk, KE; Ferrari, E; Ford, J; Guest, EM; Hesselman, MC; Hughes, AM; Jafari, R; Kees, UR; Kotecha, RS; Kuek, V; Kunold, E; Lock, RB; Loh, ML; Malinge, S; Oommen, J; Post, F; Singh, S1
Barwe, SP; Gopalakrishnapillai, A; Kolb, EA; Quagliano, A1
Kurita, R; Onishi, Y; Tomita, T1
Chijimatsu, I; Eguchi, M; Fujita, N; Hamamoto, K; Imanaka, Y; Karakawa, S; Miki, M; Nishimura, S; Tomizawa, D1
Chen, K; Deng, M; Guo, X; Jiang, Z; Li, P; Shi, P; Xu, B; Zha, J; Zhang, L1
Cui, JK; Jiang, L; Li, Q; Luo, Y; Shi, W; Xiao, Y; You, Y; Zhong, ZD1
Burkett, S; Cam, MC; Cunningham, T; Jailwala, P; Müller, F; Pastan, I; Stetler Stevenson, M; Stookey, S; Tai, CH; Wayne, AS1
Beck, D; Evans, K; Huang, Y; Jing, D; Liu, X; Lock, RB; Mayoh, C; McCalmont, H; Mi, J; Pimanda, JE; Poulos, RC; Sia, KCS; Span, M; Tai, X; Toscan, CE; Wang, M; Wong, JWH; Zhang, C; Zhang, JC1
Benayoun, E; Cordonnier, C; Maury, S; Pautas, C; Rahmé, R; Wagner-Ballon, O1
Boumber, Y; Fang, Z; Garcia-Manero, G; Gonzalez-Cervantes, EA; Kuang, SQ; Wei, Y; Yang, H; Zweidler-McKay, PA1
Bera, TK; Chertov, O; Hu, X; Pastan, I; Wayne, AS; Wei, H; Xiang, L1
De Vita, S; Ebert, BL; Garcia, M; Gavillet, M; Gerbaulet, A; Levine, RL; Mullally, A; Roers, A; Schneider, RK; Williams, DA; Wood, J1
Burke, MJ; Cao, X; Ghodke-Puranik, Y; Lamba, JK; Lindgren, BR; Miller, JS; Pounds, S; Verneris, MR; Weigel, BJ1
Benton, CB; Borthakur, G; Dara, S; Franklin, AR; Garcia-Manero, G; Jabbour, E; Kantarjian, H; Kwari, M; O'Brien, S; Pierce, SR; Ravandi, F; Rytting, M; Thomas, DA; Yang, H1
Ağaoğlu, L; Akçay, A; Can, İ; Celkan, T; Doğru, Ö; Fırtına, S; Hatırnaz Ng, Ö; Karakaş, Z; Özbek, U; Sayitoğlu, M; Timur, Ç; Yıldırmak, Y1
Eguchi, M; Eguchi-Ishimae, M; Gao, W; Inukai, T; Ishii, E; Iwabuki, H; Sugita, K; Tauchi, H; Wu, Z; Yagi, C1
Huang, YM; Xiao, HF; Xu, WQ1
Fulda, S; Gerges, S; Rohde, K1
Liu, H; Sun, Z; Tang, B; Tong, J; Zhang, L; Zhang, X; Zheng, C; Zhou, H; Zhu, X1
Barwe, SP; Gopalakrishnapillai, A; Quagliano, A1
Bueno, MJ; Calin, GA; Cigudosa, JC; Croce, CM; Fernández-Piqueras, J; Gómez de Cedrón, M; Malumbres, M; Pérez de Castro, I; Santos, J1
Bermúdez, A; Bureo, E; Iriondo, A; Richard, C; Yánez, L1
Chen, XM; Huang, S; Li, X; Liu, J; Zhou, R1
Blagitko-Dorfs, N; Daskalakis, M; Hackanson, B1
Brown, P; Figueroa, ME; Irizarry, R; McIntyre, E; Melnick, A; Negi, S; Schafer, E; Small, D1
Ahsanuddin, A; Kumar, R; Paulson, K; Seftel, MD1
Klimek, VM; Tallman, MS1
Chen, XW; Chen, YX; Li, B; Li, CG; Li, YH; Wen, FQ; Zhang, ZX1
Bera, TK; Chertov, O; FitzGerald, DJ; Pastan, I; Wayne, AS; Wei, H; Xiang, L1
Eguchi, M; Eguchi-Ishimae, M; Gao, W; Hamasaki, Y; Inukai, T; Ishii, E; Iwabuki, H; Kawakami, S; Nishi, M; Sugita, K; Tauchi, H; Wu, Z1
Hirschfeld, S; Ho, PT; Pazdur, R; Smith, M1
Buffler, PA; Gunn, L; Leung, K; Ma, X; Smith, MT; Wiemels, JL; Wiencke, JK; Zhang, L; Zheng, S1
Agrelo, R; Artiga, MJ; Espada, J; Esteller, M; Fraga, MF; Pérez-Rosado, A; Piris, MA; Rodriguez, M; Sanchez-Aguilera, A; Setien, F1
Koeffler, HP; Matsushita, M; Seo, H; Taguchi, H; Takeuchi, S; Tsukasaki, K; Yang, Y; Yoshino, N1
Ballestar, E; Carvajal-Gonzalez, JM; Esteller, M; Fernandez-Salguero, PM; Fraga, MF; Herranz, M; Mulero-Navarro, S; Ropero, S1
Agirre, X; Calasanz, MJ; Cordeu, L; Garate, L; Heiniger, A; Jiménez-Velasco, A; Prosper, F; Román-Gómez, J; San José-Eneriz, E; Torres, A1
Garcia-Manero, G; Hoshino, K; Quintás-Cardama, A; Sanchez-Gonzalez, B; Yang, H1
Archimbaud, E; Muus, P; Willemze, R1
Hoyt, PR; Popp, D; Saavedra, HI; Stambrook, PJ; Wang, TH; Yang, WK1
Archimbaud, E; Berneman, Z; Dardenne, M; Dohner, H; Jaksic, B; Jehn, U; Labar, B; Louwagie, EA; Muus, P; Stryckmans, P; Suciu, S; Tjean, M; Wijermans, P; Willemze, R; Zittoun, R1
Champlin, R; Davis, M; de Vos, D; Giralt, S; Kantarjian, H; O'Brien, S; van Besien, K1
Estey, E; Kantarjian, HM; Keating, MJ; O'Brien, S; Plunkett, W; Rios, MB; Sorenson, M; Wilhelm, M1
Fenaux, P; Quesnel, B1
Depil, S; Dussart, P; Prin, L; Roche, C1
Avramis, VI; Holcenberg, JS; Mecum, RA; Nyce, J; Steele, DA1
Bouchard, J1
Colly, LP; Richel, DJ; Willemze, R1

Reviews

3 review(s) available for azacitidine and Acute Lymphoid Leukemia

ArticleYear
Decitabine.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2010, Volume: 184

    Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Modification Methylases; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Stem Cell Transplantation; Transplantation, Homologous

2010
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

    Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine

2003
P15INK4b gene methylation and myelodysplastic syndromes.
    Leukemia & lymphoma, 1999, Volume: 35, Issue:5-6

    Topics: Acute Disease; Animals; Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Transformation, Neoplastic; Chromosomes, Human, Pair 9; Clinical Trials, Phase II as Topic; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Decitabine; Disease Progression; DNA Methylation; Genes, p16; Genes, Tumor Suppressor; Hematopoiesis; Humans; Leukemia, Myeloid; Mice; Myelodysplastic Syndromes; Neoplasm Proteins; Precancerous Conditions; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transforming Growth Factor beta; Tumor Suppressor Proteins

1999

Trials

6 trial(s) available for azacitidine and Acute Lymphoid Leukemia

ArticleYear
A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia.
    American journal of hematology, 2014, Volume: 89, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Child, Preschool; Decitabine; Disease-Free Survival; DNA Methylation; Drug Resistance, Neoplasm; Humans; Hydroxamic Acids; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Secondary Prevention; Vorinostat; Young Adult

2014
Safety and clinical activity of 5-aza-2'-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia.
    British journal of haematology, 2014, Volume: 167, Issue:3

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Decitabine; Dexamethasone; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Hyperglycemia; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Vincristine; Young Adult

2014
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia.
    Blood, 2007, Apr-15, Volume: 109, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; beta Catenin; Cell Line, Tumor; Child; Child, Preschool; Decitabine; Disease-Free Survival; DNA Methylation; Epigenesis, Genetic; Female; Follow-Up Studies; Gene Expression Regulation, Leukemic; Humans; Infant; Male; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quercetin; Signal Transduction; Wnt Proteins

2007
A randomized phase II study on the effects of 5-Aza-2'-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893).
    Leukemia, 1997, Volume: 11 Suppl 1

    Topics: Adolescent; Adult; Aged; Amsacrine; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate; Time Factors

1997
Studies of decitabine with allogeneic progenitor cell transplantation.
    Leukemia, 1997, Volume: 11 Suppl 1

    Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Combined Modality Therapy; Decitabine; Drug Administration Schedule; Hematopoietic Stem Cell Transplantation; Humans; Infusions, Intravenous; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Middle Aged; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pseudomonas Infections; Recurrence; Time Factors; Transplantation, Homologous

1997
Phase I study of arabinosyl-5-azacytidine (fazarabine) in adult acute leukemia and chronic myelogenous leukemia in blastic phase.
    Leukemia & lymphoma, 1999, Volume: 34, Issue:5-6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Azacitidine; Blast Crisis; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Salvage Therapy; Treatment Outcome

1999

Other Studies

40 other study(ies) available for azacitidine and Acute Lymphoid Leukemia

ArticleYear
Investigation the Cytotoxicity of 5-AZA on Acute Lymphoblastic Leukemia Cell Line In Vitro and Characterization the Underlying Molecular Mechanisms of Cell Death and Motility.
    Asian Pacific journal of cancer prevention : APJCP, 2021, Nov-01, Volume: 22, Issue:11

    Topics: Apoptosis; Azacitidine; Cell Death; Cell Line, Tumor; Cell Movement; DNA Methylation; Enzyme Inhibitors; Humans; MicroRNAs; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger

2021
Diagnostic challenge in mixed phenotype acute leukemia with T/megakaryocyte or T/myeloid lineages accompanied by t(3;3).
    Diagnostic pathology, 2022, Oct-05, Volume: 17, Issue:1

    Topics: Acute Disease; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Cell Lineage; Female; Humans; Immunophenotyping; Leukemia, Myeloid, Acute; Megakaryocytes; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sulfonamides

2022
Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy.
    Leukemia, 2023, Volume: 37, Issue:1

    Topics: Azacitidine; Decitabine; Humans; Infant; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2

2023
CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia.
    Blood advances, 2020, 09-22, Volume: 4, Issue:18

    Topics: Azacitidine; Bone Marrow; Child; Humans; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction; Tetraspanin 28; Tumor Microenvironment

2020
Epigenetic regulation of the circadian clock: role of 5-aza-2'-deoxycytidine.
    Bioscience reports, 2017, Jun-30, Volume: 37, Issue:3

    Topics: ARNTL Transcription Factors; Azacitidine; Carrier Proteins; Cell Line, Tumor; Circadian Clocks; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Period Circadian Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
Azacitidine successfully maintained the second remission in an infant with KMT2A-rearranged acute lymphoblastic leukemia who relapsed after unrelated cord blood transplantation.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:12

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Cord Blood Stem Cell Transplantation; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Humans; Infant; Male; Myeloid-Lymphoid Leukemia Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2017
Low-dose decitabine enhances chidamide-induced apoptosis in adult acute lymphoblast leukemia, especially for p16-deleted patients through DNA damage.
    Pharmacogenomics, 2017, Volume: 18, Issue:13

    Topics: Adolescent; Adult; Aminopyridines; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Benzamides; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Damage; Female; Gene Deletion; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2017
Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2017, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Azacitidine; Child; Combined Modality Therapy; Decitabine; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Neoplasm Recurrence, Local; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome; Young Adult

2017
5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 02-20, Volume: 115, Issue:8

    Topics: Animals; Antineoplastic Agents; Azacitidine; Bacterial Toxins; Bone Marrow; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Exotoxins; Humans; Leukemia; Mice; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2018
Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia.
    Cancer cell, 2018, 12-10, Volume: 34, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Chromatin; Dexamethasone; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Lymphocytes; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Xenograft Model Antitumor Assays

2018
Treatment with 5-azacytidin upregulates the expression of CD20 in CD20-negative B cell acute lymphoblastic leukemia: a case report.
    Experimental hematology, 2013, Volume: 41, Issue:6

    Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Combined Modality Therapy; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Fatal Outcome; Female; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cell Transplantation; Histone Deacetylase Inhibitors; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Rituximab; Salvage Therapy; Transplantation, Homologous; Up-Regulation; Valproic Acid

2013
Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Apoptosis; Azacitidine; B-Lymphocytes; Basic Helix-Loop-Helix Transcription Factors; Blood Cells; Bone Marrow; Calcium-Binding Proteins; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Silencing; Hematopoiesis; Histones; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Leukemia, B-Cell; Membrane Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Receptor, Notch3; Receptors, Notch; Repressor Proteins; Serrate-Jagged Proteins; Signal Transduction; T-Lymphocytes; Transcription, Genetic; Vorinostat

2013
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.
    Leukemia research, 2013, Volume: 37, Issue:11

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Bacterial Toxins; Blotting, Western; Cell Proliferation; DNA Methylation; Exotoxins; Gene Silencing; Humans; Minor Histocompatibility Antigens; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins

2013
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Animals; Azacitidine; Blotting, Western; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dasatinib; Decitabine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Drug Therapy, Combination; Enzyme Inhibitors; Esophagus; Gastric Mucosa; Humans; Mast Cells; Mastocytosis, Systemic; Mice, Knockout; Mice, Transgenic; Mutation, Missense; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA Interference; Skin; Stomach; Thiazoles

2014
A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2015, Volume: 32, Issue:2

    Topics: Adolescent; Azacitidine; Cell Line, Tumor; Child; Child, Preschool; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Infant, Newborn; Jurkat Cells; Male; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Wnt Signaling Pathway; Wnt-5a Protein

2015
HMGA2 as a potential molecular target in KMT2A-AFF1-positive infant acute lymphoblastic leukaemia.
    British journal of haematology, 2015, Volume: 171, Issue:5

    Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; DNA-Binding Proteins; Drug Synergism; Gene Knockdown Techniques; Genes, p16; Histone-Lysine N-Methyltransferase; HMGA2 Protein; Humans; Infant; MicroRNAs; Molecular Targeted Therapy; Myeloid-Lymphoid Leukemia Protein; Netropsin; Nuclear Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Transcriptional Elongation Factors; Up-Regulation

2015
[Expression Analysis and Epigenetics of MicroRNA let-7b in Acute Lymphoblastic Leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2015, Volume: 23, Issue:6

    Topics: Apoptosis; Azacitidine; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Humans; MicroRNAs; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction

2015
Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells.
    Cancer letters, 2016, May-28, Volume: 375, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Caspases; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Gene Knockdown Techniques; Humans; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Molecular Mimicry; Necrosis; Oligopeptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases

2016
Decitabine prior to salvaged unrelated cord blood transplantation for refractory or relapsed childhood acute leukemia.
    Pediatric transplantation, 2016, Volume: 20, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Azacitidine; Child; Child, Preschool; Cohort Studies; Cord Blood Stem Cell Transplantation; Decitabine; Female; Graft Survival; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Recurrence; Remission Induction; Time Factors; Transplantation Conditioning; Treatment Outcome

2016
Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.
    Leukemia research, 2017, Volume: 56

    Topics: Animals; Azacitidine; Coculture Techniques; DNA Modification Methylases; Drug Resistance, Neoplasm; Epigenesis, Genetic; Heterografts; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Indoles; Mice; Osteoblasts; Panobinostat; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

2017
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
    Cancer cell, 2008, Volume: 13, Issue:6

    Topics: 3' Untranslated Regions; Animals; Azacitidine; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 14; Chromosomes, Mammalian; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Loss of Heterozygosity; Lymphoma, T-Cell; Lymphoproliferative Disorders; Mice; Mice, Inbred C57BL; MicroRNAs; Phenylbutyrates; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins c-abl; Time Factors; Transfection; Up-Regulation; Whole-Body Irradiation

2008
Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia.
    Leukemia, 2009, Volume: 23, Issue:7

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Child; Decitabine; Female; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2009
Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation.
    British journal of haematology, 2010, Volume: 148, Issue:1

    Topics: Azacitidine; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Neoplasm; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; MicroRNAs; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tumor Cells, Cultured

2010
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.
    Blood, 2010, Jun-10, Volume: 115, Issue:23

    Topics: Azacitidine; Cell Line, Tumor; Child; Child, Preschool; Cohort Studies; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Rearrangement; Gene Silencing; Genome-Wide Association Study; Histone-Lysine N-Methyltransferase; Humans; Infant; Male; Myeloid-Lymphoid Leukemia Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic

2010
Azacytidine as a novel agent in the treatment of acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Female; Humans; Middle Aged; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2011
Hypomethylating agents in acute lymphoblastic leukemia: untapped potential?
    Leukemia & lymphoma, 2011, Volume: 52, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Humans; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2011
[Effect of methylation inhibitor on EphB4 gene expression, proliferation and apoptosis in CEM cells].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2012, Volume: 14, Issue:3

    Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptor, EphB4; RNA, Messenger

2012
Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, May-01, Volume: 109, Issue:18

    Topics: Azacitidine; Bacterial Toxins; Base Sequence; Cell Line, Tumor; CpG Islands; DNA Methylation; DNA, Neoplasm; Drug Resistance, Neoplasm; Exotoxins; HSP40 Heat-Shock Proteins; Humans; Immunotoxins; Molecular Sequence Data; Peptide Elongation Factor 2; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Sialic Acid Binding Ig-like Lectin 2

2012
Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements.
    Leukemia, 2013, Volume: 27, Issue:2

    Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Humans; Infant; MicroRNAs; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2013
Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.
    Cancer research, 2004, Mar-15, Volume: 64, Issue:6

    Topics: Acid Anhydride Hydrolases; Adolescent; Antimetabolites, Antineoplastic; Azacitidine; B-Lymphocytes; Child; Child, Preschool; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 21; CpG Islands; Decitabine; Diploidy; DNA Methylation; DNA, Neoplasm; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid; Male; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; T-Lymphocytes; Translocation, Genetic; Tumor Cells, Cultured

2004
Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-10, Volume: 23, Issue:17

    Topics: Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lamin Type A; Lymph Nodes; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Promoter Regions, Genetic; Survival Rate; Tumor Cells, Cultured

2005
Methylation of the MLH1 gene in hematological malignancies.
    Oncology reports, 2005, Volume: 14, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Cell Line, Tumor; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms; Humans; Jurkat Cells; Lymphoma, T-Cell; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm

2005
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding.
    Carcinogenesis, 2006, Volume: 27, Issue:5

    Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Molecular Sequence Data; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Binding; Receptors, Aryl Hydrocarbon; Sp1 Transcription Factor

2006
Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia.
    Leukemia, 2007, Volume: 21, Issue:5

    Topics: Azacitidine; CpG Islands; Decitabine; DNA Methylation; Humans; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins c-hck; src-Family Kinases

2007
Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group.
    Leukemia, 1993, Volume: 7 Suppl 1

    Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Agents; Azacitidine; Decitabine; Female; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction

1993
Interleukin-3 increases the incidence of 5-azacytidine-induced thymic lymphomas in pBOR-Il-3 mice.
    Cellular immunology, 1996, Oct-10, Volume: 173, Issue:1

    Topics: Animals; Azacitidine; Carcinogens; CD3 Complex; CD4 Antigens; CD8 Antigens; Disease Models, Animal; Female; Gene Rearrangement, T-Lymphocyte; Incidence; Interleukin-3; Male; Mice; Mice, Transgenic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymus Neoplasms

1996
Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients.
    Leukemia, 2002, Volume: 16, Issue:2

    Topics: Acute Disease; Adult; Aged; Azacitidine; Computer Systems; Endogenous Retroviruses; Female; Gamma Rays; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Viral; Genes, gag; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Phytohemagglutinins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic

2002
Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia.
    Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Azacitidine; Child; Child, Preschool; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation; Humans; Male; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tumor Cells, Cultured

1989
Mechanism of action of 5-AZA-dC: induced DNA hypomethylation does not lead to aberrant gene expression in human leukemic CEM cells.
    Leukemia research, 1989, Volume: 13, Issue:8

    Topics: Antineoplastic Agents; Azacitidine; Cell Line; Decitabine; DNA Damage; DNA, Neoplasm; Gene Expression; Humans; Kinetics; Methylation; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Neoplasm

1989
The antileukaemic activity of 5-Aza-2-deoxycytidine (Aza-dC) in patients with relapsed acute leukaemia.
    Bone marrow transplantation, 1989, Volume: 4 Suppl 3

    Topics: Antineoplastic Agents; Azacitidine; Bone Marrow; Decitabine; Drug Evaluation; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989