az-960 and Multiple-Myeloma

az-960 has been researched along with Multiple-Myeloma* in 1 studies

Other Studies

1 other study(ies) available for az-960 and Multiple-Myeloma

Article	Year
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15 Both previous and additional genetic knockdown studies reported herein implicate G protein-coupled receptor kinase 6 (GRK6) as a critical kinase required for the survival of multiple myeloma (MM) cells. Therefore, we sought to develop a small molecule GRK6 inhibitor as an MM therapeutic. From a focused library of known kinase inhibitors, we identified two hits with moderate biochemical potencies against GRK6. From these hits, we developed potent (IC Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; G-Protein-Coupled Receptor Kinases; Humans; Mice; Models, Molecular; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship	2021

Article

Year

Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.

Journal of medicinal chemistry, 2021, 08-12, Volume: 64, Issue:15

Both previous and additional genetic knockdown studies reported herein implicate G protein-coupled receptor kinase 6 (GRK6) as a critical kinase required for the survival of multiple myeloma (MM) cells. Therefore, we sought to develop a small molecule GRK6 inhibitor as an MM therapeutic. From a focused library of known kinase inhibitors, we identified two hits with moderate biochemical potencies against GRK6. From these hits, we developed potent (IC

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; G-Protein-Coupled Receptor Kinases; Humans; Mice; Models, Molecular; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship

2021