az-628 and Neoplasms

az-628 has been researched along with Neoplasms* in 1 studies

Reviews

1 review(s) available for az-628 and Neoplasms

ArticleYear
Selective Raf inhibition in cancer therapy.
    Expert opinion on therapeutic targets, 2007, Volume: 11, Issue:12

    Over the past 5 years, the Raf kinase family has emerged as a promising target for protein-directed cancer therapy development. The goal of this review is to first provide a concise summary of the data validating Raf proteins as high-interest therapeutic targets. The authors then outline the mode of action of Raf kinases, emphasizing how Raf activities and protein interactions suggest specific approaches to inhibiting Raf. The authors then summarize the set of drugs, antisense reagents and antibodies available or in development for therapeutically targeting Raf or Raf-related proteins, as well as existing strategies combining these and other therapeutic agents. Finally, the authors discuss recent results from systems biology analyses that have the potential to increasingly guide the intelligent selection of combination therapies involving Raf-targeting agents and other therapeutics.

    Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; raf Kinases

2007