ayanin has been researched along with Staphylococcal-Infections* in 1 studies
1 other study(ies) available for ayanin and Staphylococcal-Infections
| Article | Year |
|---|---|
Ayanin, a natural flavonoid inhibitor of Caseinolytic protease, is a promising therapeutic agent to combat methicillin-resistant Staphylococcus aureus infections.
Antimicrobial resistance (AMR) is a global health threat. The dramatic increase of Methicillin-resistant Staphylococcus aureus (MRSA) infections emphasizes the need to find new anti-infective agents with a novel mode of action. The Caseinolytic protease (ClpP) is a central virulence factor in stress survival, virulence, and antibiotic resistance of MRSA. Here, we found ayanin, a flavonoid isolated from Callicarpa nudiflora, was an inhibitor of MRSA ClpP with an IC Topics: Animals; Anti-Bacterial Agents; Endopeptidases; Flavonoids; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Molecular Docking Simulation; Peptide Hydrolases; Staphylococcal Infections; Staphylococcus aureus; Virulence Factors | 2023 |